Microneedle chip mounter

Abstract

The invention discloses a micro-needle chip mounter, which comprises a rack, a material strip coil, a feeding separating and winding mechanism, a carrier punching and pasting mechanism and a discharging separating and winding mechanism, and is characterized in that the rack is provided with a conveying plate and an operation area; the material strip roll is formed by rolling a material strip with continuous length, the material strip comprises an upper release film layer, a lower release film layer and a substrate sheet layer, and the substrate sheet layer is provided with a microneedle pasting groove; the carrier punching and pasting mechanism is provided with one or more punching and pasting stations, each punching and pasting station is provided with a carrier module, the micro-needle chip mounter automatically completes feeding, punching and pasting and discharging in an assembly line mode, the production efficiency is very high, in each link of feeding, punching and pasting and discharging, the production efficiency is greatly improved, and the production efficiency is greatly improved. Produced waste materials and finished products are subjected to linkage treatment through special mechanisms, the complete machine conveying and punching and pasting completeness is high, reel type components are adopted in feeding and waste material collecting for releasing and collecting, the quantity capable of being treated through single-time feeding is very large, the complete machine structure is reasonable, and large-scale industrial mass production is easy to achieve.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of patch machines, in particular to a microneedle patch machine. BACKGROUND

[0002] Microneedle patches are products used to assist in the treatment of various skin diseases, as shown in CN220989408U, and have been widely used in the fields of beauty and dermatology. Common microneedle patch products include acne patches and scar patches. By adding corresponding auxiliary treatment drugs on the microneedles, the drugs are released to the skin surface after the microneedles penetrate the skin surface (dermis), achieving the purpose of non-invasive treatment. The earliest microneedle patch is a base film layer with a microneedle layer on the top. The microneedle layer is located in the central position of the base film layer. Since the base film layer is adhesive, it can be attached to the skin. During the attachment process, the microneedles penetrate the skin. The production method is still mainly dependent on manual single attachment, and the production capacity is limited. There has been no large-scale industrial production for a long time. Publication CN112494799A discloses an automatic loading and patching device for hydrogel carriers. The device can complete the automatic film tearing and patching process. However, this patent uses single or several pieces stacked on a carrier, which is positioned by a robot combined with vision, and then punched and attached. For large-scale industrial production, this patent's technical solution to some extent replaces manual operation, but the production efficiency of the single piece stacking method is still slow. SUMMARY

[0003] In order to overcome the shortcomings of the prior art, the purpose of the present application is to provide a microneedle patch machine to solve the technical problems mentioned in the background art.

[0004] To solve the technical problems, the present application adopts the following technical solutions: A microneedle patch machine, comprising: A rack, a conveying plate and an operation area are installed on the rack; A material belt roll is formed by winding a continuous length of material belt. The material belt includes an upper release film layer, a lower release film layer and a base sheet layer. The base sheet layer is provided with a microneedle patch groove. An upper material separation and winding mechanism is installed on the head end side of the conveying plate of the rack, responsible for storing and releasing the material belt to the conveying plate, and separating and winding the upper release film layer of the material belt. A carrier punching and attaching mechanism is installed at the middle position of the rack. It has one or more punching and attaching stations. Each punching and attaching station has a separate or linked carrier module. The material belt is conveyed to the working end of the punching and attaching station through the conveying plate. The punching and attaching action end in the punching and attaching station separates the microneedle block from the carrier module and attaches it to the target microneedle patch groove of the material belt. A lower material separation and winding mechanism is installed on the tail end side of the conveying plate, responsible for separating the target base sheet layer of the punched material belt and winding the lower release film layer. Specifically, the upper release film layer and the lower release film layer of the roll of material tape are continuous in length, the substrate sheet layers are arranged equidistantly between the upper release film layer and the lower release film layer, the substrate sheet layers comprise a substrate and a water glue monomer, the substrate is provided with microneedle paste holes, and the water glue monomer is attached to the microneedle paste holes to form microneedle paste grooves. Specifically, the upper material separating and winding mechanism comprises a first winding drum for storing and releasing the roll of material tape, a first winding motor for controlling rotation of the first winding drum, a second winding drum for winding the upper release film layer, a second winding motor for controlling rotation of the second winding drum, and a first material separating assembly, the first material separating assembly is installed at the head end of the conveying plate, the first winding drum and the second winding drum are respectively installed at both sides of the conveying plate, and the material tape of the roll of material tape enters the conveying plate through the first material separating assembly and separates the upper release film layer, the reserved lower release film layer and the substrate sheet layer into the conveying plate. Specifically, the carrier punching and pasting mechanism comprises a punching and pasting seat, a punching and pasting cylinder, a carrier module, a first driving assembly and a second driving assembly, the punching and pasting cylinder is installed at the upper end of the punching and pasting seat, the output end of the punching and pasting cylinder is provided with a punching and pasting head, the punching and pasting seat is installed on the rack through the first driving assembly, the carrier module comprises a carrier group and a die group, the carrier group is installed on the rack through the second driving assembly, the die group is installed on the rack and is provided with a plurality of punching holes arranged in a regular manner on the die group, a microneedle mother plate is also placed in the die group, a punching and pasting recess is recessed on the punching and pasting seat for the die group to enter and align, a punching and pasting through hole is arranged at the lower end of the punching and pasting recess, the punching and pasting seat and the carrier module are linked to above the microneedle paste groove of the target material tape, the punching and pasting head passes through the punching hole of the die group from the upper end of the die group downward and pastes a microneedle block of a specific shape from the microneedle mother plate to the microneedle paste groove. Specifically, the lower material separating and winding mechanism comprises a third winding drum for winding the lower release film layer, a third winding motor for controlling rotation of the third winding drum, and a second material separating assembly for separating the lower release film layer from the substrate sheet layer, the second material separating assembly is arranged at the tail end of the conveying plate, and the punched and pasted material tape passes through the second material separating assembly to separate the upper release film layer and the substrate sheet layer, wherein the upper release film layer is wound by the third winding drum, and the substrate sheet layer becomes a finished microneedle paste to enter the next sorting process.

[0005] Specifically, the lower material separating and winding mechanism further comprises a fourth winding drum and a fourth winding motor for controlling rotation of the fourth winding drum, the fourth winding drum is used for winding the edge material of the lower release film layer, and the edge material is separated by the third material separating rotating rod.

[0006] The first material distribution assembly comprises a first fixed guide wheel, a first material distribution seat, and a first material distribution rotating rod. The first fixed guide wheel is installed at the upper end of the first material roll and at the front end of the conveying plate. The first material distribution seat is installed at the head end of the conveying plate and has two symmetrical seat bodies arranged on both sides of the conveying plate. The first material distribution rotating rod is rotatably arranged between the two seat bodies. The second material distribution assembly comprises a second material distribution seat and a second material distribution rotating rod. The second material distribution seat is arranged at the tail end of the conveying plate. The second material distribution rotating rod is rotatably arranged on the second material distribution seat. The first driving assembly comprises a first motor, a first driving rotating rod, a first nut block, a first sliding seat, a first sliding block, a first sliding rail, a second motor, a second driving rotating rod, a second nut block, a second sliding seat, a second sliding block, and a second sliding rail. The lower end of the first sliding seat is slidably connected to the first sliding rail through the first sliding block. The first nut block is installed at the lower end of the first sliding seat. The first motor drives the first driving rotating rod to be rotatably connected to the first nut block. The first motor controls the longitudinal movement of the first sliding seat. The second sliding rail is fixedly arranged above the first sliding seat. The lower end of the second sliding seat is slidably connected to the second sliding rail through the second sliding block. The second nut block is installed at the lower end of the second sliding seat. The second motor drives the second driving rotating rod to be rotatably connected to the second nut block. The second motor controls the transverse movement of the second sliding seat. The second sliding seat is arranged at the upper end of the first sliding seat. The punching and stamping seat is fixedly arranged above the second sliding seat. The second driving assembly comprises a third motor, a third driving rotating rod, a third nut block, a third sliding seat, a third sliding block, a third sliding rail, a fourth motor, a fourth driving rotating rod, a fourth nut block, a fourth sliding seat, a fourth sliding block, and a fourth sliding rail. The lower end of the third sliding seat is slidably connected to the third sliding rail through the third sliding block. The third nut block is installed at the lower end of the third sliding seat. The third motor drives the third driving rotating rod to be rotatably connected to the third nut block. The third motor controls the longitudinal movement of the third sliding seat. The fourth sliding rail is fixedly arranged above the third sliding seat. The lower end of the fourth sliding seat is slidably connected to the fourth sliding rail through the fourth sliding block. The fourth nut block is installed at the lower end of the fourth sliding seat. The fourth motor drives the fourth driving rotating rod to be rotatably connected to the fourth nut block. The fourth motor controls the transverse movement of the fourth sliding seat. The fourth sliding seat is arranged at the upper end of the third sliding seat. The carrier module is fixedly arranged above the fourth sliding seat.

[0007] The first driving assembly and the second driving assembly are arranged on both sides of the conveying plate.

[0008] The carrier group comprises a carrier seat and a carrier arm. The carrier seat is fixedly connected to the fourth sliding seat. One end of the carrier arm is fixedly connected to the carrier seat, and the other end extends towards the punching and stamping seat. The mold group comprises a mold bottom plate and a mold cover plate which are pressed against each other. The mold bottom plate is fixedly installed on the carrier arm. The mold bottom plate and the mold cover plate are both provided with coaxial corresponding punching holes. The microneedle mother plate is arranged between the mold bottom plate and the mold cover plate.

[0009] The feeding auxiliary mechanism comprises a second fixed guide wheel, a first floating guide wheel, a first mounting plate, a first stroke slot, a first guide sliding rail, a first guide sliding block and a stroke electronic ruler. The first mounting plate is mounted on one side of the rack. The second fixed guide wheel is mounted on the first mounting plate. The first mounting plate is provided with the first stroke slot on one side. The back side of the first mounting plate is sequentially provided with the stroke electronic ruler, the first guide sliding rail and the first guide sliding block. The first guide sliding block is slidably connected with the first guide sliding rail. One side of the first guide sliding block is hingedly connected with the output end of the stroke electronic ruler. The other side of the first guide sliding block is connected with the first floating guide wheel through a first extension rod. The first floating guide wheel is located between the first fixed guide wheel and the second fixed guide wheel. When the material belt enters the conveying plate through the second fixed guide wheel, the first floating guide wheel and the first fixed guide wheel, the stroke electronic ruler is extended to drive the first floating guide wheel to descend to tighten the material belt.

[0010] The winding auxiliary tolerance mechanism is arranged at the front end of the second winding drum of the feeding separation and winding mechanism or the front end of the fourth winding drum of the discharging separation and winding mechanism. The winding auxiliary tolerance mechanism comprises a second mounting plate, a second stroke slot, a second guide sliding rail, a second guide sliding block, a third fixed guide wheel, a second floating guide wheel, an upper stroke switch and a lower stroke switch. The front side of the second mounting plate is provided with the third fixed guide wheel. The second mounting plate is provided with the second stroke slot. The back of the second mounting plate is provided with the second guide sliding rail. The second guide sliding block is slidably arranged on the second guide sliding rail. The upper stroke switch and the lower stroke switch are arranged at the upper and lower parts of the second stroke slot. The second floating guide wheel is connected with the second guide sliding block through a second extension rod. One side of the second guide sliding block is further provided with a switch device. The switch device is in contact with the upper stroke switch or the lower stroke switch to control the upward and downward strokes of the winding auxiliary tolerance mechanism.

[0011] The pulling mechanism is arranged at the tail end of the conveying plate. The pulling mechanism comprises a pair of pulling mounting seats arranged on both sides, a first pulling wheel, a second pulling wheel, a compression adjusting assembly, a pulling motor, a main gear and a slave gear. The pulling mounting seat is provided with a first mounting area and a second mounting area. The first pulling wheel is rotatably mounted on the first mounting area. The second pulling wheel is adjustably mounted on the second mounting area. The compression adjusting assembly is mounted on one side of the second mounting area and can adjust the relative position of the second pulling wheel in the second mounting area. One end of the first pulling wheel is connected with the main gear. The main gear is connected with the pulling motor. One end of the second pulling wheel is connected with the slave gear. The slave gear is linked with the second pulling wheel and is meshed with the main gear when the second pulling wheel is moved upward to mesh with the main gear.

[0012] Specifically, the pressing adjusting assembly comprises an adjusting groove, an adjusting handle, an adjusting rod, an adjusting block, a fixing block and an adjusting spring. The adjusting groove is arranged in the second installation area. The adjusting block is slidably arranged in the adjusting groove. The second pulling wheel and the rotating shaft of the adjusting rod are sequentially and rotatably arranged at the upper and lower ends of the adjusting block. The lower end of the adjusting block is provided with a lifting spring. The outer side of the adjusting rod is connected with the adjusting handle. The adjusting rod is provided with an eccentric adjusting area. The eccentric adjusting area comprises a first contact end away from the shaft center and a second contact end close to the shaft center. The outer side of the adjusting groove is provided with the fixing block. The fixing block is provided with an adjusting contact point interacting with the eccentric adjusting area. When the first contact end of the adjusting rod contacts with the adjusting contact point by rotating the adjusting handle, the adjusting block presses the lifting spring downward, and the second pulling wheel is away from the first pulling wheel. When the second contact end contacts with the adjusting contact end, the adjusting block is lifted upward by the lifting spring, and the second pulling wheel is close to the first pulling wheel.

[0013] Specifically, the first pulling wheel and the second pulling wheel are both silica gel sleeve wheels.

[0014] The visual detection mechanism is arranged on one side of the carrier punching mechanism and is used for identifying the orientation of the substrate sheet and identifying whether the punching and the target microneedle pasting groove are coaxial.

[0015] Specifically, the lower part of the material belt and the conveying plate are further provided with a punching and pasting stabilizing mechanism. The punching and pasting stabilizing mechanism comprises a suction cavity, an electric suction disc and a lifting component. The conveying plate is provided with the suction cavity. The suction cavity is provided with the electric suction disc. The lower end of the electric suction disc is connected with the lifting component which lifts the suction disc upward.

[0016] Specifically, the output end of the punching and pasting cylinder is provided with a punching and pasting rod. The punching and pasting rod penetrates through the punching and pasting notch and the punching and pasting through hole. The punching and pasting head is located at the bottom of the punching and pasting rod. The punching and pasting head comprises a blade part and an inner tangent groove part. The bottom of the punching and pasting rod is inwardly recessed to form the inner tangent groove part. The outer side edge ring of the inner tangent groove part forms the blade part. The upper end of the punching and pasting rod is provided with a rod plug part. The inner side of the rod plug part is provided with an outer tangent air hole. The inner side of the punching and pasting rod is provided with an inner blowing air hole. The lower end of the inner blowing air hole is open and extends to the end face of the inner tangent groove part.

[0017] Compared with the prior art, the beneficial effects of the present application are as follows: (1) The microneedle patch machine adopts a flow line mode, and the feeding, punching and discharging are automatically completed, so that the production efficiency is very high.

[0018] (2) The microneedle patch machine has special mechanisms for linking and processing the waste and finished products in each link from feeding to punching to discharging, so that the transmission and punching completeness of the whole machine is high.

[0019] (3) The micro-needle patch machine of the present application adopts a roll type component for releasing and collecting in the feeding and waste collecting, and the single feeding can handle a large amount, and the whole machine structure is reasonable and easy to mass industrial production. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 : It is one of the whole structure schematic diagram of the present application patent; Figure 2 : It is the second whole structure schematic diagram of the present application patent; Figure 3 : It is the third whole structure schematic diagram of the present application patent; Figure 4 : It is the fourth whole structure schematic diagram of the present application patent; Figure 5 : It is the whole structure front view of the present application patent; Figure 6 : It is the fifth whole structure schematic diagram of the present application patent; Figure 7 : It is the sixth whole structure schematic diagram of the present application patent; Figure 6 : It is the enlarged view of F part in the sixth whole structure schematic diagram of the present application patent; Figure 8 : It is the structure schematic diagram of the carrier punching mechanism, the pulling mechanism, the first driving assembly and the second driving assembly in the present application patent; Figure 9 : Figure 8 : It is the bottom perspective angle schematic diagram in the structure shown; Figure 10 : Figure 8 : It is the second bottom perspective angle schematic diagram in the structure shown; Figure 11 : It is the structure exploded view of the carrier punching mechanism in the present application patent; Figure 12 : It is the exploded view of the pulling mechanism in the present application patent; Figure 13 : It is the exploded view of the pulling mechanism in the present application patent; Figure Two ; Figure 14 : It is the structure exploded view of the carrier module in the present application patent; Figure 15 : It is the punching and stabilizing mechanism schematic diagram in the optional embodiment of the present application patent; Figure 16 : It is the material belt structure exploded view in the present application patent; Figure 17 : It is the base sheet layer structure exploded view in the present application patent; Figure 18 : It is the base sheet layer structure cross-sectional view in the present application patent; Figure 19 : It is the punching rod structure perspective view in the present application patent;In the figure: rack 100, front side 101, back side 102, left side 103, right side 104, upper side 105, lower side 106, conveying plate 110, operation area 120, operation button 121, display screen 122, material tape roll 2, upper release film layer 21, lower release film layer 22, substrate sheet layer 23, microneedle paste groove 234, substrate 231, water glue monomer 232, microneedle paste hole 233, microneedle block 235, upper material separation and winding mechanism 4, first material winding drum 41, first material winding motor 42, second material winding drum 43, second material winding motor 44, lower material separation and winding mechanism 5, third material winding drum 51, third material winding motor 52, fourth material winding drum 53, fourth material winding motor 54, edge material 55, first material distribution assembly 6, first fixed guide wheel 61, first material distribution seat 62, first material distribution rotating rod 63, seat body 621, second material distribution assembly 7, second material distribution seat 71, second material distribution rotating rod 72, third material distribution rotating rod 73, carrier punching and pasting mechanism 3, punching and pasting station 301, carrier module 33, working end 302, punching and pasting seat 31, punching and pasting cylinder 32, first driving assembly 8, second driving assembly 9, punching and pasting head 321, punching and pasting rod 322, sharp blade part 323, inner connecting groove part 324, rod plug part 325, outer connecting air hole 326, inner blowing air hole 327, carrier frame group 331, die group 332, punching hole 334, microneedle mother board 333, punching and pasting notch 311, punching and pasting via hole 312, carrier frame seat 331a, carrier frame arm 331b, die bottom plate 332a, die cover plate 332b, magnetic attraction piece 332c, positioning pin 332d, positioning hole 332e, first motor 801, first driving rotating rod 802, first nut block 803, first sliding seat 804, first sliding block 805, first sliding rail 806, second motor 807, second driving rotating rod 808, second nut block 809, second sliding seat 810, second sliding block 811, second sliding rail 812, third motor 901, third driving rotating rod 902, third nut block 903, third sliding seat 904, third sliding block 905, third sliding rail 906, fourth motor 907, fourth driving rotating rod 908, fourth nut block 909, fourth sliding seat 910, fourth sliding block 911, fourth sliding rail 912, upper material auxiliary mechanism E, second fixed guide wheel E1, first floating guide wheel E2, first mounting plate E3, first stroke groove E4, first guide sliding rail E5, first guide sliding block E6, stroke electronic ruler E7, first extension rod E8, winding auxiliary tolerance mechanism A, second mounting plate A1, second stroke groove A2, second guide sliding rail A3, second guide sliding block A4, third fixed guide wheel A5, second floating guide wheel A6, upper stroke switch A7, lower stroke switch A8, second extension rod A9, switch device A10, material pulling mechanism B, material pulling mounting seat B1, first material pulling wheel B2, second material pulling wheel B3, compression adjusting assembly B4, material pulling motor B5, main gear B6, slave gear B7, first mounting area B8, second mounting area B9, adjusting groove B10, adjusting handle B11, adjusting rotating rod B12, adjusting block B13, fixed block B14,Adjusting spring B15, eccentric adjusting area B16, first contact end B16a, second contact end B16b, adjusting contact point B14a, silica gel sleeve wheel B17, longitudinal groove B14ab, visual detection mechanism C, camera C1, punching and pasting stabilizing mechanism D, adsorption cavity D1, electrostatic chuck D2, lifting component D3, buffer spring D5, and deviation adjusting machine A01. DETAILED DESCRIPTION

[0021] Hereinafter, the present application will be further described in conjunction with the drawings and the specific embodiments, and it should be noted that the following described embodiments or technical features can be combined in any manner to form new embodiments without conflict.

[0022] Reference Figures 1-19 : The present application discloses a microneedle patch machine, referring to Figures 1-5 , the microneedle patch machine comprises a rack 100, a material belt roll 2, a feeding, separating and winding mechanism 4, a carrier punching and pasting mechanism 3 and a discharging, separating and winding mechanism 5, the machine with the rack 100 as the main body has a front side 101, a rear side 102, a left side 103, a right side 104, an upper side 105 and a lower side 106, and the rack 100 is further provided with a conveying plate 110, an operation area 120, a vacuum pump and a control mainboard arranged inside, the conveying plate 110 is a smooth long strip plate, and in individual cases, auxiliary balls and auxiliary rollers can be arranged on the conveying plate 110 to improve the flow speed of the material belt on the conveying plate 110, the conveying plate 110 can be arranged on more than one side, and two rows can be arranged side by side, the operation area 120 is provided with components such as operation buttons 121 and a display screen 122 for controlling the coordinated work between the mechanisms, including automatic and manual control modes (manual control is required before automatic punching and pasting conditions are reached when individual parameters need to be adjusted and at the beginning of feeding); the material belt roll 2 is formed by winding a continuous length of material belt, the material belt comprises an upper release film layer 21, a lower release film layer 22 and a substrate sheet layer 23, and the substrate sheet layer 23 is provided with a microneedle patch groove 234; in an optional embodiment, a 1000-meter-long material belt roll 2 is formed into a roll, each substrate sheet layer 23 has a length of 8 cm (the width is less than the width of the material belt), and the distance between every two substrate sheet layers 23 is 2 cm, which means that the roll of material belt contains about 10,000 substrate sheet layers 23 to be punched, and 10,000 finished products can be produced after single feeding, and the production efficiency can be greatly improved through the process of raw material winding, gradual release and assembly line punching. In an optional embodiment, referring to Figure 5 and Figure 18, the upper release film layer 21 and the lower release film layer 22 of the material tape roll 2 are continuous in length, the substrate sheet layers 23 are equidistantly arranged between the upper release film layer 21 and the lower release film layer 22, the substrate sheet layers 23 comprise a substrate 231 and a water glue monomer 232, the substrate 231 is provided with microneedle pasting holes 233, and the water glue monomer 232 is attached to the microneedle pasting holes 233 to form microneedle pasting grooves 234 (microneedle pasting needs to be attached to the microneedle pasting grooves 234); it should be understood that the material tape roll 2 is wound and formed, and the substrate sheet layers 23 are equidistantly pasted to the upper release film layer 21 and the lower release film layer 22, which are prior art and are completed in the previous process, the material of the upper release film layer 21 and the lower release film layer 22 is an easy-to-tear film, such as a pvc film, preferably, the substrate 231 is a sheet type smooth surface paper or a hard shell sheet pvc plate, and the water glue monomer 232 is attached to the microneedle pasting holes 233 on the back of the substrate 231 by machine or manual method, because the water glue monomer 232 has a large area and does not need to be punched, the process is not complicated, and therefore the attachment can be completed by manual or ordinary machine in the previous process; in order to produce microneedle pasting products, a microneedle block 235 with a specific shape needs to be pasted into the microneedle pasting groove 234, the machine can automatically cut / punch the microneedle block 235 from the microneedle mother plate 333 and then paste it into the microneedle pasting groove 234, and the use of the microneedle pasting is also very simple, only the finished product needs to be taken out, the water glue monomer 232 is torn from the back to take out the microneedle block 235, and then pasted on the skin (as shown in Figure 17 and Figure 18 The single finished substrate sheet layer 23 often has several microneedle pastings (one microneedle block 235 plus one water glue monomer 232 to form one microneedle pasting).

[0023] Specifically, the feeding, separating, and winding mechanism 4 is installed on one side of the head end of the conveyor plate 110 of the frame 100. It is responsible for storing and releasing the material strip to the conveyor plate 110 and separating and winding the upper release film layer 21 of the material strip. The feeding, separating, and winding mechanism 4 includes a first roll 41 for storing and releasing the material strip roll 2, a first roll motor 42 for controlling the rotation of the first roll 41, a second roll 43 for winding the upper release film layer 21, a second roll motor 44 for controlling the rotation of the second roll 43, and a first separating component 6. The first separating component 6 is installed at the head end of the conveyor plate 110. The first roll 41 and the second roll 43 are respectively installed on both sides of the conveyor plate 110. Preferably, the first roll 41 is installed at the lower left position of the frame 100, and the second roll 43 is installed at the upper left position of the frame 100. The first roll 41 is heavier, and the material strip is separated and wound towards the lower left position. Pulling upwards can tighten the entire strip, facilitating the stamping operation. The second roll 43 is positioned directly above the first roll 41, which helps to save on the need for intermediate guide rollers and reduce deviation. The strip of the strip roll 2 enters the conveyor plate 110 through the first material distribution component 6 and separates the upper release film layer 21, the reserved release film layer 22, and the substrate layer 23 into the conveyor plate 110. In an optional embodiment, the first material distribution component 6 includes a first fixed guide roller 61, a first material distribution seat 62, and a first material distribution rotating rod 63. The first fixed guide roller 61 is installed at the front end of the conveyor plate 110 and at the upper end of the first roll 41. The first material distribution seat 62 is installed at the head end of the conveyor plate 110 and has symmetrically arranged distribution seats 621 on both sides of the conveyor plate 110. The first material distribution rotating rod 63 is rotatably arranged between the two distribution seats 621. Here, both the first fixed guide roller 61 and the first material distribution rotating rod 63 can rotate. The feeding, separating and winding mechanism 5 includes a third roll 51 for winding the lower release film layer 22, a third roll motor 52 for controlling the rotation of the third roll 51, and a second separating component 7 for separating the lower release film layer 22 from the substrate layer 23. The second separating component 7 is located at the tail end of the conveyor plate 110. The punched and pasted material strip passes through the second separating component 7 to separate the upper release film layer 21 and the substrate layer 23. The upper release film layer 21 is wound up by the third roll 51, and the substrate layer 23 becomes the finished micro-needle patch and enters the next sorting process. Specifically, the material strip is pulled or slidably conveyed by the conveyor plate 110 to the working end 302 of the punching station 301. The punching end in the punching station 301 separates the micro-needle block 235 from the carrier module 33 and attaches it to the target micro-needle groove 234 of the material strip. The unloading, separating and winding mechanism 5 is installed on one side of the tail end of the conveyor plate 110 and is responsible for separating the target substrate layer 23 in the punched material strip and winding the lower release film layer 22. It can be understood that in the foregoing upper material separation and winding mechanism 4 and lower material separation and winding mechanism 5, the material belt is first placed on the first winding drum 41, then pulled out through the deviation adjusting machine A01 (which can also be omitted), then enters the first fixed guide wheel 61 of the first material separation assembly 6 from the deviation adjusting machine A01, and after passing through the conveying plate 110 and the first material separation rotating rod 63, the upper release film layer 21 of the material belt is torn open, and then the upper release film layer 21 is wound upward around the first material separation rotating rod 63 to reach and be wound into the second winding drum 43 (the upper material separation and winding mechanism 4 process is completed). Then, after the lower release film layer 22 and the bare substrate sheet layer 23 of the material belt pass through the punching process of the carrier punching mechanism 3, the material belt with the finished substrate sheet layer 23 enters the lower material separation and winding mechanism 5. Before reaching the tail end of the conveying plate 110, the lower release film layer 22 is manually torn open (manual tearing and guiding are only needed at the beginning) and introduced into the third winding drum 51, and the lower release film layer 22 is wound by the third winding drum 51. The process substrate sheet layer 23 will not be affected and will continue to advance with the conveying plate 110 to the next process, such as bagging or sorting. The third winding drum 51 also serves as the power for the advancement of the entire material belt. It can be understood that in this embodiment, the rotation of all other motors is coordinated with the third winding motor 52.

[0024] Preferably, the first winding motor 42, the second winding motor 44, and the third winding motor 52 are all servo motors.

[0025] Specifically, the lower material separation and winding mechanism 5 further comprises a fourth winding drum 53 and a fourth winding motor 54 for controlling the rotation of the fourth winding drum 53. The fourth winding drum 53 is used to wind the edge material 55 of the lower release film layer 22. The edge material 55 refers to a situation where the lower release film layer 22 has cutting lines or easy-tear lines or dot lines or other lines for distinguishing between the middle and the edge on both sides of the substrate sheet layer 23. The lines make it easy to separate the middle region of the lower release film layer 22 from the two edge regions. The edge material 55 is separated by the third material separation rotating rod 73. The second material separation assembly 7 further comprises a second material separation seat 71 and a second material separation rotating rod 72. The second material separation seat 71 is arranged at the tail end of the conveying plate 110, and the second material separation rotating rod 72 is rotatably arranged on the second material separation seat 71. In some cases, the fourth winding drum 53 can not be used, such as when the lower release film layer 22 is integrally formed. In this case, the fourth winding drum 53 can be omitted. Preferably, the upper end surface of the second material separation rotating rod 72 is flush with the conveying plate 110, which helps the substrate sheet layer to separate from the lower release film layer when the lower release film layer passes through the second material separation rotating rod 72 and is bent downward.

[0026] In the above provided embodiments, the pulling power of the entire material belt can come from the third material winding drum 51, which is controlled by the main board. After the front carrier punching mechanism 3 finishes punching, the main board controls the third material winding drum 51 to rotate to achieve the purpose of pulling the material belt to advance. At the same time, the first material winding drum 41 rotates to release the material belt, the second material winding drum 43 rotates to wind the release film layer 21, and so on. Of course, in specific implementation, the third material winding drum 51 will have a larger diameter after winding, which will cause it to be unable to accurately adjust the length of the material belt by rotating the angle. At this time, the visual system component can be used to help identify, such as installing a visual detection analysis camera C1 on the upper end of the conveying plate 110. The camera C1 identifies that a certain substrate layer 23 enters the identification frame and identifies it as a conveying (or material pulling) pause command. After the front carrier punching mechanism 3 finishes punching the previous substrate layer 23, the pause command is released, and the third material winding drum 51 rotates until the next substrate layer 23 enters the identification frame, enters the next conveying pause command, and when the conveying / pulling is paused, the third material winding drum 51 and other material winding drums are paused. Of course, the control logic of the present patent can not be limited to this, and other more advanced control logics can also be used. In addition, the conveying plate 110 here can be replaced by a conveying belt, which is conveyed by the conveying belt.

[0027] In particular, reference is made to Figures 8-11The carrier punching mechanism 3 is installed at the middle position of the rack 100, and has one or more punching stations 301, such as two linked punching stations 301. The punching here refers to the process of removing the microneedle block 235 by downward stamping and then pasting it into the microneedle pasting groove 234. Each punching station 301 has a carrier module 33. The carrier modules of multiple punching stations 301 can be arranged in a separate working mode or a linked mode. In an optional embodiment of the linked carrier module 33, two punching stations 301 on the same side in the direction of the same conveying plate 110 are linked with each other. When the system feeds, the total number of the first punching station 301 and the second punching station 301 punching the base sheet layer 23 is calculated at the same time. For example, if each punching station 301 punches ten base sheet layers 23 at a time, the system will feed twenty base sheet layers 23 at a time when feeding. The length of the base sheet layer 23 can be controlled by combining visual control, release speed of the material belt, and rotation angle of each motor, and finally the number of base sheet layers 23 walked is determined by visual judgment. Of course, the process of punching a single base sheet layer 23 by each punching station 301 is generally the same, and the time used is also the same. For example, when the second punching station 301 punches the first base sheet layer 23, the first punching station 301 also punches the eleventh base sheet layer 23. The material belt will advance by the length of a base sheet layer 23. At this time, the second base sheet layer 23 enters the second punching station 301, and the twelfth base sheet layer 23 enters the first punching station 301. This is repeated. When the tenth base sheet layer 23 and the twentieth base sheet layer 23 are punched by the two punching stations 301, the system determines that the punching of the batch of twenty base sheet layers 23 is completed, and then enters the next feeding cycle. The next feeding number is 21-40 base sheet layers 23, of which 21-30 enter the second punching station 301 area, and 31-40 enter the first punching station 301 area. This is repeated. In this way, the two punching stations 301 can be linked and punched. This linked punching work logic can greatly improve the punching efficiency of a single assembly line. Of course, the punching station 301 in the same assembly line can also be three or four, and the corresponding control logic will also change accordingly. In addition, the assembly line can also be in a non-linked mode on both sides at the same time, that is, each side of the rack 100 has a conveying plate 110 and a punching process. In this way, the punching operations on both sides do not interfere with each other, and each assembly line can be punched independently, which is also very efficient. However, this way occupies more factory space, and a single operator may need to run back and forth between the two sides.

[0028] In particular, with reference to Figures 8-11, the punch mechanism 3 comprises a punch seat 31, a punch cylinder 32, a carrier module 33, a first driving assembly 8 and a second driving assembly 9, the punch cylinder 32 is installed at the upper end of the punch seat 31, the output end of the punch cylinder 32 is provided with a punch head 321, the punch seat 31 is installed on the rack 100 through the first driving assembly 8, the carrier module 33 comprises a carrier group 331 and a die group 332, wherein the carrier group 331 is installed on the rack 100 through the second driving assembly 9, the die group 332 is installed on the rack 100 and is provided with a plurality of regularly arranged punch holes 334, and a microneedle mother plate 333 is also placed in the die group 332, the microneedle mother plate 333 is a paper plate full of microneedles produced in the previous process, a punch recess 311 for the plate-shaped die group 332 to enter and align is recessed on the punch seat 31, a punch through hole 312 is arranged at the lower end of the punch recess 311, and the lower area of the punch through hole 312 constitutes a working end 302 of a punch station 301, the punch seat 31 and the carrier module 33 are linked above the microneedle paste groove 234 of the target material belt, the punch head 321 passes through the punch hole 334 of the die group 332 from the upper end of the die group 332 downward and pastes a microneedle block 235 of a specific shape from the microneedle mother plate 333 to the microneedle paste groove 234, in an optional embodiment, the punch head 321 is a flat head at the bottom of the output rod of the punch cylinder 32, the microneedle mother plate 333 is extruded with a punch line (a trace line or a dot line of a specific shape) in the previous process by realizing the arrangement position of each punch hole 334 of the die group 332, when the microneedle mother plate 333 is placed in the die group 332, a single microneedle block 235 to be punched can be aligned with a single microneedle block 331 by manual alignment, when the punch head 321 is punched downward from the upper end, a microneedle block 235 is brought down, the system quickly pastes the microneedle block 235 brought down to the target microneedle paste groove 234 above by setting a specific punch stroke, in another optional embodiment, the microneedle mother plate 333 does not have a punch line, the punch head 321 is a recessed ring-shaped tubular component with a blade part, the punch head 321 can cut off the microneedle block 235 downward from the punch hole 334 by utilizing inertia and the characteristics that the microneedle mother plate 333 is fastened in the die group 332, and then reaches 1mm above the microneedle paste groove 234 under the control of the stroke, and the microneedle block 235 is blown to the microneedle paste groove 234 by blowing gas into the punch head 321 through an additional channel in the cylinder, and the implementation is not limited here.

[0029] In addition, with reference to Figures 8-11, the punch 334 and the punch seat 31 linkage mode can be realized by coding the punch hole, for example, the punch 334 on the single mold group 332 has 20 rows and 50 columns, a total of 1000 punch holes 334, then the row is coded with m and the column is coded with q, for example, the first row of the third type of punch hole 334 is represented by m1q3, then the system will automatically calibrate the coordinates of the punch hole 334 into the system, which coordinates the microneedle slot 234 below the punch head 321. The movement of the first drive assembly 8 and the second drive assembly 9 can achieve the punch hole 334 to the bottom of the punch head 321, and the corresponding substrate layer 23 below the punch hole changes with the change of the microneedle slot 234. The system linkage changes in this way. Each punch hole 334 is coded, and the system enters a complete set of punch hole 334 codes and related linkage information, so that each substrate layer 23 can be punched. Of course, this system can also be combined with a visual perception system to identify the position change of the punch hole 334 and the microneedle slot 234 to make corresponding changes in the linkage information, and the control mode is not limited to a single type. Specifically, referring to Figures 8-11 , the first drive assembly 8 includes a first motor, a first drive shaft 802, a first nut block 803, a first sliding seat 804, a first sliding block 805, a first sliding rail 806, a second motor 807, a second drive shaft 808, a second nut block 809, a second sliding seat 810, a second sliding block 811 and a second sliding rail 812. The lower end of the first sliding seat 804 is connected with the first sliding rail 806 through the first sliding block 805, and the first nut block 803 is installed at the lower end of the first sliding seat 804. The first motor drives the first drive shaft 802 to rotate with the first nut block 803, and the first motor controls the longitudinal movement of the first sliding seat 804. The second sliding rail 812 is fixedly arranged above the first sliding seat 804. The lower end of the second sliding seat 810 is connected with the second sliding rail 812 through the second sliding block 811, and the second nut block 809 is installed at the lower end of the second sliding seat 810. The second motor 807 drives the second drive shaft 808 to rotate with the second nut block 809, and the second motor 807 controls the transverse movement of the second sliding seat 810. The second sliding seat 810 is located at the upper end of the first sliding seat 804, and the punch seat 31 is fixed above the second sliding seat 810. In this way, the punch seat 31 can change its horizontal position in the transverse and longitudinal directions, and the position change can be linked.

[0030] Specifically, referring to Figures 8-11The second driving assembly 9 comprises a third motor 901, a third driving rotating rod 902, a third nut block 903, a third sliding base 904, a third sliding block 905, a third sliding rail 906, a fourth motor 907, a fourth driving rotating rod 908, a fourth nut block 909, a fourth sliding base 910, a fourth sliding block 911 and a fourth sliding rail 912. The lower end of the third sliding base 904 is slidably connected to the third sliding rail 906 through the third sliding block 905. The third nut block 903 is installed at the lower end of the third sliding base 904. The third motor 901 drives the third driving rotating rod 902 to be rotationally connected to the third nut block 903. The third motor 901 controls the longitudinal movement of the third sliding base 904. The fourth sliding rail 912 is fixedly arranged above the third sliding base 904. The lower end of the fourth sliding base 910 is slidably connected to the fourth sliding rail 912 through the fourth sliding block 911. The fourth nut block 909 is installed at the lower end of the fourth sliding base 910. The fourth motor 907 drives the fourth driving rotating rod 908 to be rotationally connected to the fourth nut block 909. The fourth motor 907 controls the transverse movement of the fourth sliding base 910. The fourth sliding base 910 is located at the upper end of the third sliding base 904. The carrier module 33 is fixed above the fourth sliding base 910. In this way, the linkage change of the transverse and longitudinal positions of the carrier module 33 in the horizontal direction can be realized. The first driving assembly 8 and the second driving assembly 9 are arranged on the two sides of the conveying plate 110.

[0031] Reference Figure 14The carrier group 331 includes a carrier seat 331a and a carrier arm 331b, wherein the carrier seat 331a is fixedly connected with the fourth sliding seat 910, one end of the carrier arm 331b is fixedly connected with the carrier seat 331a, and the other end extends to the direction of the punching and stamping seat 31. The die group 332 includes a die bottom plate 332a and a die cover plate 332b which are pressed against each other. The die bottom plate 332a is fixedly installed on the carrier arm 331b. The die bottom plate 332a and the die cover plate 332b are both provided with coaxial corresponding punching holes 334. The microneedle mother plate 333 is placed between the die bottom plate 332a and the die cover plate 332b. The microneedle mother plate 333 is a paper plate full of microneedles produced in the previous process. The thickness of the paper plate is customized according to requirements. Here, the pressing between the die bottom plate 332a and the die cover plate 332b can be tightened by bolts. Of course, in order to quickly replace the microneedle mother plate 333, the magnetic attraction mode can also be used for positioning and pressing. Specifically, the die bottom plate 332a is installed on the carrier arm 331b. When it is necessary to replace the microneedle mother plate 333, the microneedle cover plate is directly removed, the punched microneedle mother plate 333 is removed, and then a new microneedle mother plate 333 is replaced in a flat manner. Then, the microneedle cover plate is placed on the microneedle mother plate 333 in a corresponding position. Preferably, the magnetic member 332c is arranged at the lower end surface of the microneedle cover plate. In order to further improve the axial positioning when the microneedle cover plate is longitudinally covered on the microneedle mother plate 333, the positioning pin 332d and the positioning hole 332e can also be used for positioning between the microneedle cover plate and the microneedle bottom plate. For example, four positioning pins 332d are arranged at four corner positions of the microneedle bottom plate, and four positioning holes 332e are arranged at four corner positions of the microneedle cover plate. In this way, the microneedle mother plate 333 can be pressed tightly by using the gravity of the microneedle cover plate.

[0032] Specifically, the material belt needs to be pulled manually before it is punched and stamped from the conveying plate 110 to the punching and stamping operation. However, this method has a disadvantage that a large amount of waste material is generated from the head end to the tail end of the conveying plate 110 to the position of the third material roller 51. One way is to set a certain length of invalid material belt at the head end of the material belt. The invalid material belt does not have a substrate layer 23. Another way is to manually punch back after the material belt is pulled into position, and then manually adjust to the forward direction for punching and stamping after the punching and stamping is completed. Specifically, referring to Figure 6 and Figure 7Before the material tape reaches the predetermined position by manual feeding, all motors will be set to the unlocked state, at this time the tension is loose, there is no resistance, and once the material tape reaches the final specified position, such as the position of the third material drum 51 where the release film layer 22 reaches, the material tape needs to be tightened at this time. An auxiliary mechanism is provided here, called the feeding auxiliary mechanism E, which includes a second fixed guide wheel E1, a first floating guide wheel E2, a first mounting plate E3, a first stroke slot E4, a first guide sliding rail E5, a first guide sliding block E6, and a stroke electronic ruler E7. The first mounting plate E3 is installed on one side of the rack 100, the second fixed guide wheel E1 is installed on the first mounting plate E3, the first mounting plate E3 is provided with a first stroke slot E4 on one side, and the back side of the first mounting plate E3 is sequentially provided with a stroke electronic ruler E7, a first guide sliding rail E5 and a first guide sliding block E6. The first guide sliding block E6 is slidably connected with the first guide sliding rail E5, one side of the first guide sliding block E6 is hingedly connected with the output end of the stroke electronic ruler E7, and the other side is connected with the first floating guide wheel E2 through a first extension rod E8. The first floating guide wheel E2 is located between the first fixed guide wheel 61 and the second fixed guide wheel E1. When the material tape sequentially passes through the second fixed guide wheel E1, the first floating guide wheel E2 and the first fixed guide wheel 61 into the conveying plate 110 for shaping, the output end of the stroke electronic ruler E7 outputs a specific length under the control of the system with constant length or constant pressure, so that the first guide sliding block E6 drives the first floating guide wheel E2 to descend to tighten the material tape. The material tape is tightened to facilitate the punching and stamping work of the punching and stamping station 301. When the material tape needs to be replaced after punching and stamping, the stroke electronic ruler E7 rises, and the material tape is released from the tightened state. Of course, the stroke electronic ruler E7 can also be replaced by a gas cylinder, a motor and a screw nut assembly.

[0033] Specifically, the second winding drum 43 is used to wind the waste of the release film layer 21, and the winding power comes from the second winding motor 44. Normally, when the first winding motor 42 rotates, the second winding motor 44 also rotates at the same time. The two motors are synchronized to complete the winding while releasing. However, in individual cases, there may be a deviation in the length of the winding of the two motors. The source of the deviation comes from the fact that the sizes of the winding of the two motors in different time periods result in different thicknesses of the periphery. Therefore, the angles and the number of turns of the two motors are also deviated. The risk brought by such deviation is that the second winding motor 44 may continuously rotate and pull the release film layer to break. At this time, a tolerance mechanism is needed, which is called a winding auxiliary tolerance mechanism A. The winding auxiliary tolerance mechanism A is arranged at the front end of the second winding drum 43 of the feeding and separating winding mechanism 4 or the front end of the fourth winding drum 53 of the discharging and separating winding mechanism 5. The winding auxiliary tolerance mechanism A includes a second mounting plate A1, a second stroke groove A2, a second guide rail A3, a second guide block A4, a third fixed guide wheel A5, a second floating guide wheel A6, an upper stroke switch A7 and a lower stroke switch A8. The front side 101 of the second mounting plate A1 is provided with the third fixed guide wheel A5. The second mounting plate A1 is provided with the second stroke groove A2. The back of the second mounting plate A1 is provided with the second guide rail A3. The second guide block A4 is slidingly arranged on the second guide rail A3. The upper stroke switch A7 and the lower stroke switch A8 are arranged at the upper and lower parts of the second stroke groove A2. The second floating guide wheel A6 is connected with the second guide block A4 through a second extension rod A9. One side of the second guide block A4 is further provided with a switch A10. The switch A10 is in contact with the upper stroke switch A7 or the lower stroke switch A8 to control the upward and downward strokes of the winding auxiliary tolerance mechanism A. Specifically, the material belt comes out of the first feeding rotating rod 63, first passes around the upper end face of the third fixed guide wheel A5, then winds downward below the second floating guide wheel A6, and then enters into the second winding drum 43 upward, thereby forming a mechanism capable of lifting the second floating guide wheel A6 to provide a margin tolerance. REFERENCE Figure 7The switch A10 is preferably a shutter, and the upstroke switch A7 and the downstroke switch A8 are a laser switch or an infrared switch. When the shutter shields a stroke switch, the laser switch or the infrared switch signal is shielded, and is regarded as the stroke switch being opened. For example, when the shutter A10 reaches the downstroke switch A8 and shields the downstroke switch A8, the downstroke switch A8 is regarded as being opened, which is caused by the material belt being too loose, or the first material roll 41 releasing too fast and the second material roll 43 winding up too slowly, resulting in too much upper release film on the second floating guide wheel A6, and finally causing the second floating guide wheel A6 to move downward in the second stroke groove A2 with the excess upper release film, and finally causing the shutter A10 to trigger the downstroke switch A8. Conversely, when the shutter A10 reaches the upstroke switch A7, which is caused by the material belt being pulled out completely, or the first material roll 41 releasing the material belt too slowly, resulting in the second floating guide wheel A6 having insufficient upper release film layer 21, the upper release film layer 21 being pulled tight by the second material roll 43, and thus causing the second floating guide wheel A6 to move upward along the second stroke groove A2, and finally causing the shutter A10 to touch the upstroke switch A7. In this case, whether the shutter A10 touches the upstroke switch A7 or the downstroke switch A8, the system will make a judgment and issue a command to stop the operation of a certain motor or process, thereby protecting the smooth operation of the machine.

[0034] In particular, reference is made to Figure 3 , Figure 12 and Figure 13, the aforementioned has been described one of the control logic of the feeding power, is through the third material winding drum 51 located at the tail end of the conveying plate 110 side of the motor pull down the release film layer 22 as the power of the material belt forward, in this kind of power logic, the third material winding drum 51 because of itself need to roll down the release film layer 22, when the amount of the release film layer 22 is rolled down more and more, its own weight plus the need to pull easy to lead to the third material winding motor 52 in line with the surge, here to provide another kind of auxiliary mechanism of feeding power, called the material pulling mechanism B, said material pulling mechanism B is installed in the tail end position of the conveying plate 110, including a pair of material pulling mounting seat B1, first material pulling wheel B2, second material pulling wheel B3, compression adjusting assembly B4, material pulling motor B5, main gear B6, gear B7 located at the lower end of the conveying plate both sides, said material pulling mounting seat B1 is provided with a first installation area B8 and a second installation area B9, the first material pulling wheel B2 is rotatably mounted on the first installation area B8, the second material pulling wheel B3 can be adjusted up and down and is mounted in the second installation area B9, the compression adjusting assembly B4 is mounted on one side of the second installation area B9 and can adjust the relative position of the second material pulling wheel B3 in the second installation area B9, one end of the first material pulling wheel B2 is connected with the main gear B6, the main gear B6 is connected with the material pulling motor B5, one end of the second material pulling wheel B3 is connected with the gear B7, the gear B7 is linked with the second material pulling wheel B3 and is moved up to engage with the main gear B6 when it engages with the main gear B6, when the main gear B6 engages with the gear B7, the rotation direction of the first material pulling wheel B2 and the second material pulling wheel B3 is opposite, when the gap between the first material pulling wheel B2 and the second material pulling wheel B3 is small enough to clamp the release film layer 22, at this time, the first material pulling wheel B2 and the second material pulling wheel B3 can provide the second pulling force for the pulling of the release film layer 22, thereby greatly reducing the load of the third material winding motor 52.

[0035] In particular, with reference to Figures 12-13The pressing adjusting assembly B4 comprises an adjusting groove B10, an adjusting handle B11, an adjusting rotating rod B12, an adjusting block B13, a fixing block B14 and an adjusting spring B15. The adjusting groove B10 is arranged on the second installation area B9 of the material pulling installation base B1. The adjusting block B13 is slidably arranged in the adjusting groove B10. The adjusting block B13 is preferably a sliding block type. The cross section of the adjusting block B13 can be designed as a concave shape, a convex shape or the like. The second material pulling wheel B3 and the rotating shaft of the adjusting rotating rod B12 are sequentially and rotatably arranged at the upper and lower ends of the adjusting block B13. The lower end of the adjusting block B13 is provided with a lifting spring. The outer side of the adjusting rotating rod B12 is connected with the adjusting handle B11. The adjusting rotating rod B12 is provided with an eccentric adjusting area B16. The eccentric adjusting area B16 comprises a first contact end B16a away from the shaft center and a second contact end B16b close to the shaft center. The outer side of the adjusting groove B10 is provided with the fixing block B14. The fixing block B14 is provided with an adjusting contact point B14a interacting with the eccentric adjusting area B16. Preferably, the adjusting contact point B14a is a recess formed by upwardly recessing the fixing block B14. When the adjusting handle B11 is rotated to make the first contact end B16a of the adjusting rotating rod B12 contact with the adjusting contact point B14a, the adjusting block B13 presses the lifting spring downward, and the second material pulling wheel B3 is away from the first material pulling wheel B2. When the second contact end B16b contacts with the adjusting contact end, the adjusting block B13 is lifted upward by the lifting spring, and the second material pulling wheel B3 is close to the first material pulling wheel B2. Preferably, the eccentric adjusting area B16 is a groove arranged on the side of the adjusting rotating rod B12 facing the adjusting contact point B14a. When the handle is rotated, the groove of the adjusting rotating rod B12 faces the adjusting contact point B14a of the fixing block B14. At this time, the second contact point faces upward, the spring lifts the adjusting block B13 upward, and the second material pulling wheel B3 is close to the first material pulling wheel B2, thereby reducing the gap for pulling operation. When the remaining material belt needs to be taken off after starting the feeding or completing the operation, the handle is reversely rotated, so that the first contact point faces upward. The first contact point is the end away from the shaft center, thereby forming an eccentric structure. The first contact point contacts with the adjusting contact point B14a. Finally, the lower end of the adjusting rotating rod B12 presses the adjusting spring B15. At this time, the adjusting block B13 lacks the upward lifting force of the adjusting spring B15. The second material pulling wheel B3 and the adjusting block B13 move downward relying on the self-gravity, so that the gap between the second material pulling wheel B3 and the first material pulling wheel B2 is increased. Finally, the excess material belt can be easily pulled out. Preferably, the first material pulling wheel B2 and the second material pulling wheel B3 are both silica gel sleeve wheels B17. The silica gel sleeve wheel B17 can increase the friction force of the first material pulling wheel B2 and the second material pulling wheel B3 on the active type lower separation film layer 22, thereby accurately controlling the size of the pulled material. Preferably, the fixing block B14 is used as a supporting point when the adjusting rotating rod B12 rotates. The height of the fixing block B14 on the adjusting groove B10 can be changed. The two sides of the fixing block B14 are provided with longitudinal grooves B14ab.The fixed block B14 is fixed with the pulling material mounting seat B1 through bolts, and the longitudinal position of the fixed block B14 is adjusted; when the fixed block B14 is adjusted downward, the height of the adjusting contact point B14a is adjusted to be low, the second contact point of the rotating rod B12 is adjusted to be upward, and the adjusting block B13 reduces the upward stroke, so that the pressing degree of the second pulling material wheel B3 and the first pulling material wheel B2 is reduced; on the contrary, when the fixed block B14 is adjusted upward, the pressing degree of the second pulling material wheel B3 and the first pulling material wheel B2 is increased, so that the tightness can be adjusted.

[0036] In order to increase the identification and calibration ability of the device, the microneedle patch machine further comprises a visual detection mechanism C installed on one side of the carrier punching mechanism 3 and used for identifying the orientation of the base sheet layer 23 and identifying whether the punching hole 334 and the target microneedle patch groove 234 are coaxial. Specifically, the visual detection mechanism C comprises a plurality of visual detection cameras C1, the camera C1 shoots a high-definition image for comparison with the saved picture of the system, and when the similar proportion reaches a certain proportion (such as 95%), it is considered as an effective position. The visual detection mechanism C is mainly used for matching the position of the base sheet layer 23 and the punching station 301, and the number of base sheet layer 23 feeding, to accurately control the size of the material belt running. The installation position of the camera C1 can be above the conveying plate 110, can be at the lowermost end of the punching seat 31, one side of the punching through hole 312 or other places conducive to detecting the position of the base sheet layer.

[0037] Specifically, referring to Figure 15, the material belt on the conveying plate 110 is still likely to be loose when passing through the punching station 301 for punching, and therefore, a punching stabilizing mechanism D is further arranged below the material belt and in the conveying plate 110, the punching stabilizing mechanism D comprises a suction cavity D1, an electric suction disc D2 and a lifting component D3, the conveying plate 110 is provided with the suction cavity D1, the suction cavity D1 is upwardly open and the material belt just passes through the opening of the suction cavity D1, the electric suction disc D2 is arranged in the suction cavity D1, and the lower end of the electric suction disc D2 is connected with the lifting component D3 for lifting the electric suction disc D2 upwardly, when the system judges that the position is in the middle through the visual detection mechanism C and gives the instruction of downward punching of the punching head 321 in the punching station 301, the lifting component D3 lifts the electric suction disc D2 upwardly to the lower surface of the lower release film layer 22 of the material belt, and the material belt is adsorbed, when the current several substrate layers and the material belt need to continue to advance after punching, the electric suction disc D2 is released from adsorption, and the lifting mechanism moves downwardly with the electric suction disc D2, and the process is repeated, the lifting mechanism can be a pneumatic cylinder or an electric cylinder, the normal electric cylinder or pneumatic cylinder can control the stroke to control the electric suction disc D2 to reach the opening of the suction cavity D1, but in some cases, the electric suction disc D2 can exceed the conveying plate 110 (suction cavity D1), in order to prevent the electric suction disc D2 from being lifted upwardly too much, a buffer mechanism such as a buffer spring D5 can be further arranged at the connection between the electric suction disc D2 and the lifting mechanism, so that the suction disc has a buffer force when being lifted upwardly, and the lifting mechanism has a correction mechanism in the control process, in the subsequent improved embodiments, the two sides of the conveying plate 110 can be provided with limiting fences, the edges of the limiting fences are provided with rollers, the limiting fences limit the deviation of the material belt, and the rollers help the material belt to advance more smoothly, and in addition, the number of the punching stabilizing mechanism D is indefinite, and the punching stabilizing mechanisms D are arranged at equal intervals on the conveying plate 110.

[0038] Reference Figure 11 and Figure 19Specifically, the output end of the punching cylinder 32 is provided with a punching rod 322, the punching rod 322 passes through the punching notch 311 and the punching through hole 312, the punching head 321 is located at the bottom of the punching rod 322, the punching head 321 comprises a blade part 323 and an inscribed groove part 324, the bottom of the punching rod 322 is recessed inward to form the inscribed groove part 324, the outer side edge ring of the inscribed groove part 324 forms the blade part 323, the upper end of the punching rod 322 is provided with a rod plug part 325, the inner side of the rod plug part 325 is provided with an circumscribed air hole 326, the inner side of the punching rod 322 is provided with an inner blowing air hole 327, the lower end of the inner blowing air hole 327 is opened and extends to the end face of the inscribed groove part 324, after the punching rod 322 passes through the punching hole 334 and cuts off the microneedle block 235 of a specific shape from the microneedle mother board 333 by the punching force, the microneedle block 235 is embedded into the inscribed groove part 324 due to the downward pressing force of the inscribed groove part 324, and finally the microneedle block 235 is blown onto the microneedle sticking groove 234 by the air blown from the inner blowing air hole 327.

[0039] The above embodiments are only preferred embodiments of the present application, and cannot be used to limit the protection scope of the present application. Any non-essential changes and replacements made by those skilled in the art based on the present application shall fall within the protection scope of the present application.

Claims

1. A microneedle patch machine, comprising: a frame, a conveying plate and an operation area are installed on the frame; a material tape roll is formed by winding a continuous length of material tape, the material tape comprises an upper release film layer, a lower release film layer and a substrate sheet layer, and the substrate sheet layer is provided with microneedle patch grooves; an upper material tape separating and winding mechanism is installed on the head end side of the conveying plate of the frame, and is responsible for storing and releasing the material tape to the conveying plate and separating and winding the upper release film layer of the material tape; a carrier punching and patching mechanism is installed at the middle position of the frame, and has one or more punching and patching stations, each of which has a single or linked carrier module, the material tape is conveyed to the working end of the punching and patching station through the conveying plate, and the punching and patching action end in the punching and patching station separates the microneedle block from the carrier module and patches it into the target microneedle patch groove of the material tape; a lower material tape separating and winding mechanism is installed on the tail end side of the conveying plate, and is responsible for separating the target substrate sheet layer in the punched material tape and winding the lower release film layer.

2. The microneedle patch machine of claim 1, wherein the microneedle patch machine further comprises a controller configured to control the microneedle patch machine to perform the method of claim 1. The upper release film layer and the lower release film layer of the material tape roll are continuous in length, and the substrate sheet layer is equidistantly arranged between the upper release film layer and the lower release film layer, the substrate sheet layer comprises a substrate and a water glue monomer, the substrate is provided with microneedle patch holes, and the water glue monomer is attached to the microneedle patch holes on one side of the substrate to form microneedle patch grooves; The upper material tape separating and winding mechanism comprises a first material winding drum for storing and releasing the material tape roll, a first material winding motor for controlling the rotation of the first material winding drum, a second material winding drum for winding the upper release film layer, a second material winding motor for controlling the rotation of the second material winding drum, and a first material separating assembly, the first material separating assembly is installed on the head end of the conveying plate, the first material winding drum and the second material winding drum are respectively installed on both sides of the conveying plate, and the material tape of the material tape roll enters the conveying plate through the first material separating assembly and separates the upper release film layer, the reserved lower release film layer and the substrate sheet layer into the conveying plate.

3. The microneedle patch machine of claim 2, wherein the microneedle patch machine further comprises a controller configured to control the microneedle patch machine to perform the method of claim 1. The carrier punching and patching mechanism comprises a punching and patching seat, a punching and patching cylinder, a carrier module, a first driving assembly and a second driving assembly, the punching and patching cylinder is installed on the upper end of the punching and patching seat, the output end of the punching and patching cylinder is provided with a punching and patching head, the punching and patching seat is installed on the frame through the first driving assembly, the carrier module comprises a carrier group and a mold group, the carrier group is installed on the frame through the second driving assembly, the mold group is installed on the frame and is provided with a plurality of regularly arranged punching holes on the mold group, and a microneedle mother plate is placed in the mold group, a punching and patching recess is recessed on the punching and patching seat for the mold group to enter and align, the lower end of the punching and patching recess is provided with a punching and patching through hole, the punching and patching seat and the carrier module are linked above the target microneedle patch groove of the material tape, the punching and patching head passes through the punching hole of the mold group from the upper end of the mold group downward and punches a microneedle block of a specific shape from the microneedle mother plate to the microneedle patch groove. The carrier group comprises a carrier seat and a carrier arm, wherein the carrier seat is fixedly connected with the fourth sliding seat, one end of the carrier arm is fixedly connected with the carrier seat, and the other end extends towards the punching and pasting seat; the die group comprises a die bottom plate and a die cover plate which are pressed against each other, the die bottom plate is fixedly installed on the carrier arm, coaxial punching holes are arranged on the die bottom plate and the die cover plate, and a microneedle mother plate is arranged between the die bottom plate and the die cover plate.

4. The microneedle patch machine of claim 3, wherein the microneedle patch machine further comprises a controller configured to control the microneedle patch machine to perform the method of claim 1. The unloading separation and winding mechanism comprises a third winding cylinder for winding the lower release film layer, a third winding motor for controlling the rotation of the third winding cylinder, and a second material separation assembly for separating the lower release film layer from the substrate sheet layer, the second material separation assembly is arranged at the tail end of the conveying plate, and the punched and pasted material belt passes through the second material separation assembly to separate the upper release film layer and the substrate sheet layer, wherein the upper release film layer is wound by the third winding cylinder, and the substrate sheet layer becomes a finished microneedle patch and enters the next sorting process; The first material separation assembly comprises a first fixed guide wheel, a first material separation seat and a first material separation rotating rod, the first fixed guide wheel is installed at the front end of the conveying plate and the upper end of the first winding cylinder, the first material separation seat is installed at the head end of the conveying plate and has two separation seat bodies which are symmetrically arranged at the two sides of the conveying plate, and the first material separation rotating rod is rotatably arranged between the two separation seat bodies, the second material separation assembly comprises a second material separation seat and a second material separation rotating rod, wherein the second material separation seat is arranged at the tail end of the conveying plate, and the second material separation rotating rod is rotatably arranged on the second material separation seat.

5. The microneedle patch machine of claim 3, wherein the microneedle patch machine further comprises a controller configured to control the microneedle patch machine to perform the method of claim 1. The first driving assembly comprises a first motor, a first driving rotating rod, a first nut block, a first sliding seat, a first sliding block, a first sliding rail, a second motor, a second driving rotating rod, a second nut block, a second sliding seat, a second sliding block and a second sliding rail, wherein the lower end of the first sliding seat is slidably connected with the first sliding rail through the first sliding block, the first nut block is installed at the lower end of the first sliding seat, the first motor drives the first driving rotating rod to be rotatably connected with the first nut block, the first motor controls the longitudinal movement of the first sliding seat, the second sliding rail is fixedly arranged above the first sliding seat, the lower end of the second sliding seat is slidably connected with the second sliding rail through the second sliding block, the second nut block is installed at the lower end of the second sliding seat, the second motor drives the second driving rotating rod to be rotatably connected with the second nut block, the second motor controls the transverse movement of the second sliding seat, the second sliding seat is located at the upper end of the first sliding seat, and the punching and pasting seat is fixed above the second sliding seat. The second driving assembly comprises a third motor, a third driving rotating rod, a third nut block, a third sliding base, a third sliding block, a third sliding rail, a fourth motor, a fourth driving rotating rod, a fourth nut block, a fourth sliding base, a fourth sliding block and a fourth sliding rail, the lower end of the third sliding base is slidably connected to the third sliding rail through the third sliding block, the third nut block is installed at the lower end of the third sliding base, the third motor drives the third driving rotating rod to be rotationally connected to the third nut block, the third motor controls the longitudinal movement of the third sliding base, the fourth sliding rail is fixedly arranged above the third sliding base, the lower end of the fourth sliding base is slidably connected to the fourth sliding rail through the fourth sliding block, the fourth nut block is installed at the lower end of the fourth sliding base, the fourth motor drives the fourth driving rotating rod to be rotationally connected to the fourth nut block, the fourth motor controls the transverse movement of the fourth sliding base, the fourth sliding base is located at the upper end of the third sliding base, and the carrier module is fixed above the fourth sliding base.

6. The microneedle patch machine of claim 1, wherein, The feeding auxiliary mechanism comprises a second fixed guide wheel, a first floating guide wheel, a first mounting plate, a first stroke slot, a first guide sliding rail, a first guide sliding block and a stroke electronic ruler. The first mounting plate is installed on one side of the rack. The second fixed guide wheel is installed on the first mounting plate. The first mounting plate is provided with the first stroke slot on one side. The stroke electronic ruler, the first guide sliding rail and the first guide sliding block are sequentially installed on the back side of the first mounting plate. The first guide sliding block is slidably connected to the first guide sliding rail. One side of the first guide sliding block is hingedly connected to the output end of the stroke electronic ruler, and the other side is connected to the first floating guide wheel through a first extension rod. The first floating guide wheel is located between the first fixed guide wheel and the second fixed guide wheel. When the material belt enters the shaping plate through the second fixed guide wheel, the first floating guide wheel and the first fixed guide wheel, the stroke electronic ruler is extended to make the first guide sliding block drive the first floating guide wheel to descend to tighten the material belt.

7. The microneedle patch machine of claim 1, wherein the microneedle patch machine is characterized by, The winding auxiliary tolerance mechanism is arranged at the front end of the second winding cylinder of the feeding separation and winding mechanism or the front end of the fourth winding cylinder of the discharging separation and winding mechanism. The winding auxiliary tolerance mechanism comprises a second mounting plate, a second stroke slot, a second guide sliding rail, a second guide sliding block, a third fixed guide wheel, a second floating guide wheel, an upper stroke switch and a lower stroke switch. The front side of the second mounting plate is provided with the third fixed guide wheel. The second mounting plate is provided with the second stroke slot. The back of the second mounting plate is provided with the second guide sliding rail. The second guide sliding block is slidably arranged on the second guide sliding rail. The upper stroke switch and the lower stroke switch are arranged at the upper and lower parts of the second stroke slot. The second floating guide wheel is connected to the second guide sliding block through a second extension rod. One side of the second guide sliding block is further provided with a switch device. The switch device is in contact with the upper stroke switch or the lower stroke switch to control the upward and downward strokes of the winding auxiliary tolerance mechanism.

8. The microneedle patch machine of claim 1, wherein, The pulling mechanism is installed at the tail end of the conveying plate, and comprises a pair of pulling mounting seats, a first pulling wheel, a second pulling wheel, a pressing adjusting assembly, a pulling motor, a main gear and a slave gear. The pressing adjusting assembly comprises an adjusting groove, an adjusting handle, an adjusting rod, an adjusting block, a fixing block and an adjusting spring.

9. The microneedle patch machine of claim 1, wherein, The pulling mounting seat is provided with the adjusting groove at the second mounting area.

10. The microneedle patch machine of claim 1, wherein, The visual detection mechanism is installed on one side of the punching and pasting mechanism and is used for identifying the orientation of the base sheet layer and identifying whether the punching and the target microneedle pasting groove are coaxial.

11. The microneedle patch machine of claim 3, wherein the microneedle patch machine is characterized by, The conveying plate is provided with the suction cavity, and the suction cavity is provided with the electrostatic chuck. The output end of the punching cylinder is provided with a punching rod, the punching rod passes through the punching notch and the punching through hole, the punching head is located at the bottom of the punching rod, the punching head comprises a blade part and an inner tangent groove part, the bottom of the punching rod is inwardly recessed to form the inner tangent groove part, the outer side edge ring of the inner tangent groove part forms the blade part, the upper end of the punching rod is provided with a rod plug part, the inner side of the rod plug part is provided with an outer tangent air hole, the inner side of the punching rod is provided with an inner blowing air hole, and the lower end of the inner blowing air hole is open and extends to the end face of the inner tangent groove part.

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