Tumor electric field treatment system

Abstract

The invention provides a tumor electric field treatment system, which comprises an electrode plate and a controller, the electrode plate comprises a plurality of electrode units and a plurality of temperature detection units, the plurality of temperature detection units are divided into a plurality of row groups and a plurality of column groups, and the grounding ends of the temperature detection units in each row group are jointly connected to the same grounding wire. The signal end of each temperature detection unit in each column group is in short circuit with the corresponding electrode unit and then is connected to the same dual-purpose signal line; a direct current signal or an alternating current signal can be accessed to the dual-purpose signal line, and when the direct current signal is accessed to the dual-purpose signal line, all the grounding wires are sequentially conducted so that temperature detection signals detected by all the temperature detection units can be collected line by line; when the dual-purpose signal line is connected with an alternating-current electric signal, the alternating-current electric signal is transmitted to each electrode unit. In this way, temperature detection and zone control can be performed on the electrode plate by using fewer conductive traces.

Description

[0001] The present application is a divisional application of the application patent application with application number 202411499593.0, entitled "Tumor electric field treatment system, electrode sheet, tumor treatment device and method", filed on October 25, 2024. TECHNICAL FIELD

[0002] The present application relates to tumor electric field treatment technology, in particular to a tumor electric field treatment system. BACKGROUND

[0003] Tumor electric field treatment is a method of treating tumors by low-intensity, medium-high frequency alternating electric field, preventing the formation of spindle microtubules in the mitosis process of certain tumor cells, inhibiting the separation of intracellular organelles in the cell division phase, and inducing apoptosis of cells in the mitosis phase, thereby achieving the effect of treating tumors.

[0004] Compared with traditional cancer treatment methods, tumor electric field treatment has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as geometry and high-frequency mitosis, make them susceptible to tumor electric field treatment. Tumor electric field treatment destroys the normal aggregation of tubulin by exerting a directional force on intracellular polar particles (such as macromolecules and organelles). These processes can lead to physical disruption of the cell membrane and apoptosis. At the end of cell mitosis, the structure of the cleavage furrow leads to uneven distribution of the electric field around it, and under the influence of tumor electric field treatment, the electric field intensity at the cleavage furrow is significantly enhanced, and the charged substances in the cell move towards the cleavage furrow, disrupting the formation of cell structures and even destroying them, ultimately leading to cell division failure and apoptosis.

[0005] In the related art, the tumor electric field treatment system uses an electric field application device to transmit an alternating electric signal for tumor electric field treatment to an electrode sheet, and then applies an alternating electric field to the tumor site of the patient through the electrode sheet to perform tumor electric field treatment. When the tumor treatment electric field is applied to the patient's body, heat will accumulate at the application site, and the temperature will also rise accordingly, so it is necessary to monitor the temperature at the application site, and when the temperature is too high, the electric field intensity needs to be adjusted in time to reduce the risk of skin burns caused by excessively high temperature.

[0006] The tumor electric field treatment system includes at least one pair of electrode sheets, and each electrode sheet has a plurality of electrode units. Even if the same alternating electric signal is applied to each electrode unit, the heat generated on each electrode unit will be different due to the different positions of the electrode units, that is, the temperature of each electrode unit on the whole electrode sheet will not be completely consistent, so that the temperature of some electrode units in the whole electrode sheet may exceed the preset temperature, while the temperature of other electrode units is normal. In order to improve the effect of tumor electric field treatment, individual control needs to be implemented on the over-temperature electrode units. However, for the electrode sheet in the related art, individual control on the electrode units needs to set a conductive trace for each electrode unit in the substrate of the electrode sheet, which will increase the conductive traces in the electrode sheet substrate so that the electrode sheet is not easy to bend, and the cable electrically connected with the electrode sheet will also be thickened, so that the overall weight of the electrode sheet is increased, which is not conducive to the application of the electrode sheet. SUMMARY

[0007] The present application aims to at least partially solve one of the technical problems in the related art. To this end, the first object of the present application is to provide a tumor electric field treatment system which can control a plurality of electrode units in zones using fewer conductive traces, thereby not only improving the effect of tumor electric field treatment, but also being conducive to the application of the electrode sheet.

[0008] To achieve the above object, the tumor electric field treatment system provided by the embodiments of the present application comprises: an electrode sheet comprising a plurality of electrode units and a plurality of temperature detection units, each of the electrode units can apply an alternating electric signal, each of the temperature detection units is arranged corresponding to one of the electrode units to detect the temperature at each of the electrode units, and the signal end of each of the temperature detection units is respectively short-circuited with the corresponding electrode unit, wherein the plurality of temperature detection units are configured as a plurality of row groups and a plurality of column groups in circuit, the ground ends of each of the temperature detection units in the same row group are short-circuited to the same ground line, and the ground ends of each of the temperature detection units in different row groups are respectively connected in parallel through different ground lines; the signal ends of each of the temperature detection units in the same column group are short-circuited to the same dual-purpose signal line, and the signal ends of each of the temperature detection units in different column groups are respectively connected in parallel through different dual-purpose signal lines; the ground line is configured to ground the ground ends of each of the temperature detection units in the corresponding row group; the dual-purpose signal line is configured to access an alternating current signal to transmit the alternating current signal to each of the electrode units in the corresponding column group or access a direct current signal to transmit the direct current signal to the signal ends of each of the temperature detection units in the corresponding column group; and a controller is configured to control each of the ground lines and each of the dual-purpose signal lines, so as to (1) when the dual-purpose signal line accesses the direct current signal, sequentially turn on each of the ground lines to make the temperature detection signals detected by each of the temperature detection units be collected row by row; and (2) when the dual-purpose signal line accesses the alternating current signal, transmit the alternating electric signal to each of the electrode units in the corresponding column group through the dual-purpose signal line.

[0009] According to the tumor electric field treatment system provided by the embodiments of the present application, the plurality of temperature detection units of the electrode sheet are divided into a plurality of row groups and a plurality of column groups, the ground ends of the temperature detection units corresponding to each of the electrode units in each row group are commonly connected to a ground line, the signal ends of the temperature detection units corresponding to each of the electrode units in each column group are respectively short-circuited with the corresponding electrode unit and then commonly connected to the same dual-purpose signal line, and the controller controls the dual-purpose signal line to access a direct current signal or an alternating current signal, so as to sequentially turn on each of the ground lines to make the temperature detection signals detected by each of the temperature detection units be collected row by row when the dual-purpose signal line accesses the direct current signal, and transmit the alternating electric signal to each of the electrode units through the dual-purpose signal line when the dual-purpose signal line accesses the alternating current signal. In this way, the sampling of the temperature and the application of the alternating electric signal can be realized through the dual-purpose signal line, without adding a new alternating current signal line (i.e. an AC line) and without eliminating the original alternating current signal line, so that a smaller number of conductive traces can be used to control a plurality of electrode units in different zones, which can not only improve the effect of the tumor electric field treatment, but also facilitate the application of the electrode sheet.

[0010] The above description is only a summary of the technical solutions of the present application. In order to make the technical means of the present application more clearly understood and implemented according to the content of the description, and in order to make the above and other purposes, characteristics and advantages of the present application more obvious and easy to understand, the following specific embodiments of the present application are described. BRIEF DESCRIPTION OF DRAWINGS

[0011] Figure 1 A schematic diagram of a tumor electric field treatment system according to an embodiment of the present application;

[0012] Figure 2 A schematic diagram of an electrode sheet of a tumor electric field treatment system according to an embodiment of the present application; Figure 1

[0013] Figure 3 A schematic diagram of the circuit connection between an electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present application; Figure 1

[0014] A schematic diagram of another circuit connection between an electrode sheet and an adapter of a tumor electric field treatment system according to an embodiment of the present application; Figure 4 Figure 3 Figure 3 A schematic diagram of the circuit connection between an electrode sheet, an adapter and an electric field generator of a tumor electric field treatment system according to an embodiment of the present application;

[0015] Figure 5 A schematic diagram of the internal structure of an adapter of a tumor electric field treatment system according to an embodiment of the present application; Figure 1

[0016] A schematic diagram of the internal structure of an electric field generator of a tumor electric field treatment system according to an embodiment of the present application; Figure 6 Figure 1 A schematic diagram of the flow of an electrode sheet temperature detection method according to an embodiment of the present application;

[0017] Figure 7 Figure 1 A schematic diagram of the flow of an electrode sheet abnormality detection method according to an embodiment of the present application;

[0018] Figure 8 A schematic diagram of the flow of a control method of a tumor electric field treatment system according to an embodiment of the present application;

[0019] Figure 9 A schematic diagram of the flow of an electrode sheet type identification method according to an embodiment of the present application;

[0020] Figure 10 A schematic diagram of the flow of an electrode sheet type identification method according to an embodiment of the present application;

[0021] Figure 11 A schematic diagram of the flow of an electrode sheet type identification method according to an embodiment of the present application;

[0022] Figure 12 ​​​​​Flowchart of a signal control method for tumor electric field therapy according to an embodiment of the present application;

[0023] Figure 13 Flowchart of an electrode temperature detection method according to another embodiment of the present application;

[0024] Figure 14 Flowchart of an alternating electric signal application method for tumor electric field therapy according to another embodiment of the present application;

[0025] Figure 15 Flowchart of an alternating electric signal application method based on a temperature detection signal according to an embodiment of the present application;

[0026] Figure 16 Flowchart of an alternating electric signal application method based on a temperature detection signal according to another embodiment of the present application.

[0027] Figure 17 Schematic diagram of a tumor electric field therapy system according to another embodiment of the present application;

[0028] Figure 18 Schematic diagram of the circuit connection between an electrode and an adapter and an electric field generator of a tumor electric field therapy system according to another embodiment of the present application;

[0029] Figure 19 Schematic diagram of the internal structure of an adapter of a tumor electric field therapy system according to Figure 18 Schematic block diagram of the internal structure of an electric field generator of a tumor electric field therapy system according to

[0030] Figure 20 Schematic diagram of the internal structure of an adapter of a tumor electric field therapy system according to Figure 18 Schematic block diagram of the internal structure of an electric field generator of a tumor electric field therapy system according to

[0031] Figure 21 Flowchart of a control method for a tumor electric field therapy system according to another embodiment of the present application;

[0032] Figure 22 Flowchart of a signal control method for tumor electric field therapy according to another embodiment of the present application;

[0033] Explanation of reference numerals:

[0034] The tumor electric field treatment system 100 or 100', the electrode sheet 13 or 13', the first cable 15 or 15', the adapter 20 or 20', the second cable 25 or 25', the electric field generator 30 or 30', the base plate 31 or 31', the electrode unit 33 or 33', the temperature detection unit 35 or 35', the ground terminal 35-1 or 35-1', the signal terminal 35-2 or 35-2', the temperature sensor 34 or 34', the ground terminal 34-1 or 34-1', the signal terminal 34-2 or 34-2', the electrode unit 33 or 33', the diode 36 or 36', the anode 36-1 or 36-1', the cathode 36-2 or 36-2', the second power supply module 32 or 32', the second controller 37 or 37', the second communication unit 38 or 38', the alternating current signal generator 39 or 39', the power supply switch 40 or 40', the first controller 51 or 51', the ADC unit 52 or 52', the voltage dividing resistor 53 or 53', the control switch 54 or 54', the first control switch 54-1 or 54-1', the second control switch 54-2 or 54-2', the third control switch 54-3 or 54-3', the fourth control switch 54-4 or 54-4', the bidirectional switch 55 or 55', the first bidirectional switch 55-1 or 55-1', the second bidirectional switch 55-2 or 55-2', the third bidirectional switch 55-3 or 55-3', the fourth bidirectional switch 55-4 or 55-4', the fifth bidirectional switch 55-5 or 55-5', the first communication unit 56 or 56', the alternating current power line 57 or 57', the first power supply module 58 or 58', the ground line 18 or 18', the first ground line 18-1 or 18-1', the second ground line 18-2 or 18-2', the third ground line 18-3 or 18-3', the fourth ground line 18-4 or 18-4', the dual-purpose signal line 19 or 19', the first dual-purpose signal line 19-1 or 19-1', the second dual-purpose signal line 19-2 or 19-2', the third dual-purpose signal line 19-3 or 19-3', the fourth dual-purpose signal line 19-4 or 19-4', the fifth dual-purpose signal line 19-5 or 19-5', the first connector 60 or 60', the first plug 61, the first socket 62, the second connector 70 or 70', the second plug 71 or 71', the second socket 72 or 72'. DETAILED DESCRIPTION

[0035] The embodiments of the technical scheme of the present application will be described in detail below with reference to the drawings. The following embodiments are only used to more clearly illustrate the technical scheme of the present application, and therefore only serve as examples, and cannot limit the protection scope of the present application.

[0036] Embodiment 1:

[0037] Figure 1 The tumor electric field treatment system 100 of an embodiment of the present application is shown. As shown in FIG. 1, the tumor electric field treatment system 100 comprises an electrode sheet 13, a first cable 15, an adapter 20, a second cable 25, an electric field generator 30, a base plate 31, an electrode unit 33, a temperature detection unit 35, a temperature sensor 34, a diode 36, a second power supply module 32, a second controller 37, a second communication unit 38, an alternating current signal generator 39, a power supply switch 40, a first controller 51, an ADC unit 52, a voltage dividing resistor 53, a control switch 54, a first communication unit 56, an alternating current power line 57, a first power supply module 58, a ground line 18, a first ground line 18-1, a second ground line 18-2, a third ground line 18-3, a fourth ground line 18-4, a dual-purpose signal line 19, a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, a fifth dual-purpose signal line 19-5, a first connector 60, a first plug 61, and a first socket 62.Figure 1 As shown, the tumor electric field therapy system 100 includes: at least one pair of electrode pads 13, an adapter 20 connected to the at least one pair of electrode pads 13, and an electric field generator 30 connected to the adapter 20. The at least one pair of electrode pads 13 can be disposed in pairs on the patient's body surface, such as... Figure 1 The device comprises four electrode pads 13, with each pair of electrode pads 13 positioned on the patient's body surface. An electric field generator 30 supplies power to at least one pair of electrode pads 13, causing them to generate an alternating electric field for tumor treatment. An adapter 20 is electrically connected between the at least one pair of electrode pads 13 and the electric field generator 30, for transmitting the alternating electrical signal generated by the electric field generator 30 to the at least one pair of electrode pads 13. In other words, the electric field generator 30 generates an alternating electrical signal, which is transmitted through the adapter 20 to each electrode pad 13, thereby generating an alternating electric field for tumor treatment between the same pair of electrode pads 13, thus applying the alternating electric field to the patient's tumor site for tumor therapy.

[0038] like Figure 1 As shown, in this embodiment, there are four electrode pads 13, each electrode pad 13 including the same number of electrode units 33, each electrode unit 33 being electrically connected to the adapter 20, and each electrode pad 13 having 20 electrode units 33. In other embodiments, the tumor electric field therapy system 100 may have more or fewer electrode pads 13; in other embodiments, each pair of electrode pads 13 has the same number of electrode units 33, and different pairs of electrode pads 13 may have different numbers of electrode units 33; in other embodiments, the number of electrode units 33 on each electrode pad 13 may be 9, 13, etc.

[0039] Figure 3 and Figure 4 for Figure 1 The diagram shows the circuit connection between the electrode 13 and the adapter 20 in two operating states of the tumor electric field therapy system 100. It is worth noting that: Figure 3 and Figure 4 The arrangement of electrode units 33 shown is to more clearly illustrate the electrical connection between an electrode piece 13 and the adapter 20. Figure 3 and Figure 4 The arrangement of electrode units 33 shown does not represent their spatial arrangement. (Combined with...) Figure 1 , Figure 3 as well as Figure 4The electrode sheet 13 comprises a substrate 31, a plurality of electrode units 33 electrically connected to the substrate 31 at intervals, a plurality of temperature detecting units 35, and a first cable 15 electrically connected to the substrate 31. The substrate 31 can be a flexible circuit board. The substrate 31 is embedded with a plurality of conductive tracks, including a plurality of ground lines 18 and a plurality of dual-purpose signal lines 19. The first cable 15 has a plurality of core wires (not shown), each of which is electrically connected to one of the plurality of ground lines 18 and one of the plurality of dual-purpose signal lines 19 of the substrate 31. In the embodiment, the total number of the ground lines 18 and the dual-purpose signal lines 19 embedded in the substrate 31 is no more than 10, and thus the number of the core wires of the first cable 15 is no more than 10.

[0040] The plurality of electrode units 33 are arranged in a plurality of row groups and a plurality of column groups. In the embodiment, there are 20 electrode units 33 on each electrode sheet 13, which are arranged in four row groups and five column groups in the order of 1-20 in circuit connection, i.e., the 20 electrode units 33 are arranged in four rows and five columns in circuit connection. Each electrode unit 33 corresponds to one temperature detecting unit 35, and each temperature detecting unit 35 has a signal end 35-2 and a ground end 35-1. The electrode units 33 and the temperature detecting units 35 are all welded on the substrate 31, and the electrode units 33 are short-circuited with the signal ends 35-2 of the corresponding temperature detecting units 35. Since the plurality of temperature detecting units 35 are arranged one-to-one with the plurality of electrode units 33, the plurality of temperature detecting units 35 are also arranged in four row groups and five column groups in circuit connection. It should be noted that the arrangement mode herein is to more clearly show the electrical connection between the electrode sheet 13 and the adapter 20, and does not represent the spatial arrangement of the electrode units 33. The spatial arrangement of the electrode units 33 can be, for example, Figure 2The roughly arrayed structure shown can also be other structures, such as petal-shaped or scattered, and can be regular or irregular structures. The electrode units 33 are configured to apply an alternating electric field to a tumor site of a patient. The temperature detection units 35 are configured to detect the temperature of the patient's body surface in contact with the electrode sheet 13, that is, the temperature at the corresponding electrode unit 33, and output a temperature detection signal to the adapter 20. In this embodiment, the multiple two-way signal lines 19 of the substrate 31 are respectively arranged in one-to-one correspondence with the multiple column groups of the electrode units 33, and are configured to transmit the alternating electric signal generated by the electric field generator 30 to each electrode unit 33 in the corresponding column group. That is, the electrode units 33 in the same column group are all short-circuited through the same two-way signal line 19 of the substrate 31, and the electrode units 33 in different column groups are respectively connected in parallel through different two-way signal lines 19 of the substrate 31. The two-way signal lines 19 of the substrate 31 are electrically connected to the first cable 15, and then electrically connected to the electric field generator 30 through the adapter 20. Further, the two-way signal lines 19 of the substrate 31 receive the alternating electric signal generated by the electric field generator 30 through the first cable 15 and the adapter 20.

[0041] The electrode sheet 13 has three modes of working states. In the first mode, an alternating electric signal is applied through the electrode units 33. In the second mode, the temperature of the patient's body surface in contact with the corresponding electrode unit 33 is detected or collected through the temperature detection units 35. In the third mode, the alternating electric signal is stopped from being applied and the temperature detection and collection are stopped. The first mode, the second mode, and the third mode do not overlap in time periods. That is, the time period during which the electrode units 33 apply the alternating electric signal is staggered and does not overlap with the time period during which the temperature detection units 35 detect the temperature. The electrode sheet 13 can be cyclically switched between applying the alternating electric signal through the electrode units 33 and detecting the temperature through the temperature detection units 35, that is, the electrode sheet 13 is cyclically switched between the first mode and the second mode. The electrode sheet 13 can also be cyclically switched between the first mode, the second mode, and the third mode, that is, the electrode sheet 13 is cyclically switched between applying the alternating electric signal through the electrode units 33, collecting or detecting the temperature through the temperature detection units 35, and stopping the application of the alternating electric signal and the collection of the temperature.

[0042] The multiple ground lines 18 are respectively arranged in one-to-one correspondence with the multiple row groups of the electrode units 33, and are respectively used to sequentially short-circuit the ground of each temperature detection unit 35 in each row group. That is, the ground ends 35-1 of the multiple temperature detection units 35 in the same row group are each short-circuited through the same ground line 18 of the substrate 31, and the ground ends 35-1 of the temperature detection units 35 in different row groups are respectively connected in parallel through different ground lines 18 of the substrate 31. During the time period for temperature detection, only one of the multiple ground lines 18 is conductive at the same time, and the other three are disconnected.

[0043] Each of the multiplexed dual-purpose signal lines 19 is also configured to short the signal terminal 35-2 of at most one temperature detection unit 35 in each row group to an external device for receiving the detection signal, wherein the signal terminals 35-2 of the temperature detection units 35 connected by each of the multiplexed dual-purpose signal lines 19 are different from each other to avoid subsequent output of repeated signals by the dual-purpose signal lines 19. That is, when the number of electrode units 33 in a row group is equal to the number of the multiplexed dual-purpose signal lines 19, each of the multiplexed dual-purpose signal lines 19 is electrically connected to the signal terminal 35-2 of a different temperature detection unit 35 in the row group, respectively; when the number of electrode units 33 in a row group is less than the number of the multiplexed dual-purpose signal lines 19, there is at least one multiplexed dual-purpose signal line 19 that is not electrically connected to the signal terminal 35-2 of a temperature detection unit 35, and the remaining multiplexed dual-purpose signal lines 19 are electrically connected to the signal terminals 35-2 of different temperature detection units 35 in the row group, respectively. In the present embodiment, the external device for receiving the detection signal is the adapter 20. The signal terminals 35-2 of the plurality of temperature detection units 35 located in different column groups are connected in parallel through different multiplexed dual-purpose signal lines 19 of the substrate 31, respectively, and the signal terminals 35-2 of the plurality of temperature detection units 35 located in the same column group are all shorted to the same multiplexed dual-purpose signal line 19 of the substrate 31.

[0044] In the present embodiment, in the case that each electrode unit 33 is configured with a temperature detection unit 35 for temperature detection, the above-mentioned line design is used to reduce the number of conductive lines of the first cable 15, avoid thickening of the cable, hardening of the softness of the cable, and increase the difficulty of cable fixation; at the same time, the increase in the number of conductive lines of the first cable 15 does not affect the adhesion effect between the electrode patch 13 and the corresponding body surface of the tumor site of the patient. The embedded ground lines 18 and the multiplexed dual-purpose signal lines 19 in the substrate 31 are a total of 9 lines. Specifically, in the present embodiment, the embedded ground lines 18 in the substrate 31 are 4 lines, and the multiplexed dual-purpose signal lines 19 are 5 lines. The number of ground lines 18 is related to the number of row groups M of electrode units 33, which is greater than or equal to the number of row groups of electrode units 33, and M is a positive integer. The number of multiplexed dual-purpose signal lines 19 is related to the number of column groups N of electrode units 33, which is greater than or equal to the number of column groups of electrode units 33, and N is a positive integer. The number of lines L embedded in the substrate 31 of the electrode patch 13 is equal to the sum of the number of ground lines 18 and the number of multiplexed dual-purpose signal lines 19. In the present embodiment, the number of ground lines 18 is equal to the number of row groups M of electrode units 33; the number of multiplexed dual-purpose signal lines 19 is equal to the number of column groups N of electrode units 33.

[0045] The plurality of electrode units 33 are arranged in a substantially two-dimensional array on the substrate 31. As shown in FIG. 1, the plurality of electrode units 33 are arranged in a plurality of row groups and a plurality of column groups on the substrate 31. The number of row groups M of electrode units 33 is equal to the number of ground lines 18 embedded in the substrate 31, and the number of column groups N of electrode units 33 is equal to the number of multiplexed dual-purpose signal lines 19 embedded in the substrate 31. Figure 2As shown, the electrode sheet 13 in this embodiment includes 20 electrode units 33 and 20 temperature detection units 35 corresponding to the electrode units 33, and the 20 electrode units 33 are arranged in an array of four rows and six columns. The first and fourth rows each include four electrode units 33, and the second and third rows each include six electrode units 33. The four electrode units 33 in each of the first and fourth rows are located in the second to fifth columns, and the six electrode units 33 in each of the second and third rows are located in the first to sixth columns. The four electrode units 33 in the first row are divided into region 1, the electrode units 33 in the first column of the second row and the first column of the third row and the second and third columns of the fourth row are divided into region 2, the electrode units 33 in the sixth column of the second row and the sixth column of the third row and the fourth and fifth columns of the fourth row are divided into region 3, the electrode units 33 in the second and third columns of the second row and the second and third columns of the third row are divided into region 4, and the electrode units 33 in the fourth and fifth columns of the second row and the fourth and fifth columns of the third row are divided into region 5. Each region (1-5) corresponds to a column group. In other embodiments, the 20 electrode units 33 can be arranged in other ways. Of course, in other embodiments, the electrode sheet 13 can have other numbers of electrode units 33. In general, the implementation of the present application is not limited by the number and arrangement of the electrode units 33 of the electrode sheet 13.

[0046] Each electrode unit 33 can apply an alternating electric signal, and the electrode pieces 13 arranged in pairs are used to apply an alternating electric field to the tumor site of the patient. Alternatively, the electrode unit 33 can be a dielectric element, such as a ceramic piece, or a polymer dielectric layer formed of a polymer material. Each temperature detection unit 35 is arranged corresponding to an electrode unit 33 to detect the temperature at the corresponding electrode unit 33. Each temperature detection unit 35 can be arranged at any position of the corresponding electrode unit 33. In the present embodiment, each electrode unit 33 is provided with a through hole 331, which is adapted to mount the temperature detection unit 35. For example, each electrode unit 33 has a through hole 331 arranged in the middle, and each electrode unit 33 has a corresponding temperature detection unit 35 received in the through hole 331. Each temperature detection unit 35 includes a temperature sensor 34 and a diode 36. The temperature sensor 34 has a signal terminal 34-2 and a ground terminal 34-1. The diode 36 has an anode 36-1 and a cathode 36-2. The anode 36-1 of the diode 36 is connected to the ground terminal 34-1 of the temperature sensor 34. The cathode 36-2 of the diode 36 serves as the ground terminal 35-1 of the temperature detection unit 35. The signal terminal 34-2 of the temperature sensor 34 serves as the signal terminal 35-2 of the temperature detection unit 35. The temperature sensor 34 can be a thermistor or other temperature sensor other than a thermistor. Each temperature sensor 34 has a corresponding diode 36 connected in series with the corresponding temperature sensor 34. The diode 36 can prevent reverse current from other electrode units 33 to prevent the detection signal from other electrode units 33 from affecting the temperature sensor 34.

[0047] As Figure 3 or Figure 4As shown, the electrode sheet 13 of the present embodiment includes four ground lines 18, each of which is used to ground the ground terminals 35-1 of the temperature detection units 35 of the same row group. The four ground lines 18 of the electrode sheet 13 are respectively a first ground line 18-1, a second ground line 18-2, a third ground line 18-3, and a fourth ground line 18-4. In the four row groups of the electrode sheet 13, the first row group is the electrode units 33-1 to 33-5, the second row group is the electrode units 33-6 to 33-10, the third row group is the electrode units 33-11 to 33-15, and the fourth row group is the electrode units 33-16 to 33-20. Specifically, the first ground line 18-1 is used to ground the electrode units 33-1 to 33-5 in the first row group; the second ground line 18-2 is used to ground the electrode units 33-6 to 33-10 in the second row group; the third ground line 18-3 is used to ground the electrode units 33-11 to 33-15 in the third row group; and the fourth ground line 18-4 is used to ground the electrode units 33-16 to 33-20 in the fourth row group. It should be noted that these ground lines 18 can be selectively closed or opened, which can be achieved by connecting each ground line 18 in series with a control switch 54, i.e., the ground terminals 35-1 of the temperature detection units 35 corresponding to the electrode units 33 in each row group are connected to the ground pin through a control switch 54 in common, which will be described in detail below. The above-mentioned "grounding the electrode units 33" can refer to grounding the ground terminals 34-1 of the temperature sensors 34 corresponding to the electrode units 33, or can refer to the diodes 36 and the corresponding temperature sensors 34 being connected in series and grounded together. In short, each ground line 18 shorts and grounds the ground terminals 35-1 of the temperature detection units 35 corresponding to all the electrode units 33 in each row group.

[0048] As Figure 3 or Figure 4As shown, the electrode sheet 13 of the present embodiment also includes five two-way signal lines 19, one end of each of the two-way signal lines 19 is connected to all the electrode units 33 in each column group and the signal end 35-2 of the corresponding temperature detection unit 35 of each electrode unit 33, and the other end is connected to the adapter 20 for receiving the temperature detection signal and transmitting the alternating electric signal. That is, for each row group, each of the two-way signal lines 19 can be selectively connected to one of the electrode units 33 or none of the electrode units 33 in the row group to avoid subsequent output of duplicate signals by the two-way signal line 19. Specifically, the five two-way signal lines 19 of the electrode sheet 13 include a first two-way signal line 19-1, a second two-way signal line 19-2, a third two-way signal line 19-3, a fourth two-way signal line 19-4, and a fifth two-way signal line 19-5. One end of the first two-way signal line 19-1 is simultaneously connected to the electrode unit 33-1, the electrode unit 33-6, the electrode unit 33-11, the electrode unit 33-16, and the signal end 35-2 of the corresponding temperature detection unit 35 of each of the four electrode units 33; one end of the second two-way signal line 19-2 is simultaneously connected to the electrode unit 33-2, the electrode unit 33-7, the electrode unit 33-12, the electrode unit 33-17, and the signal end 35-2 of the corresponding temperature detection unit 35 of each of the four electrode units 33; one end of the third two-way signal line 19-3 is simultaneously connected to the electrode unit 33-3, the electrode unit 33-8, the electrode unit 33-13, the electrode unit 33-18, and the signal end 35-2 of the corresponding temperature detection unit 35 of each of the four electrode units 33; one end of the fourth two-way signal line 19-4 is simultaneously connected to the electrode unit 33-4, the electrode unit 33-9, the electrode unit 33-14, the electrode unit 33-19, and the signal end 35-2 of the corresponding temperature detection unit 35 of each of the four electrode units 33; and one end of the fifth two-way signal line 19-5 is connected to the electrode unit 33-5, the electrode unit 33-10, the electrode unit 33-15, the electrode unit 33-20, and the signal end 35-2 of the corresponding temperature detection unit 35 of each of the four electrode units 33. In short, each of the two-way signal lines 19 parallelly connects the signal end 35-2 of each of the electrode units 33 and the corresponding temperature detection unit 35 in the same column group and is used to connect to an external device. It should be noted that the two-way signal lines 19 can selectively transmit the alternating electric signal or receive the temperature detection signal, which can be achieved by connecting each of the two-way signal lines 19 in series with a bidirectional switch 55 and cooperating with the closing or opening of the ground line 18.That is, after the signal terminals 35-2 of the temperature detecting units 35 in each column group are respectively short-circuited with the corresponding electrode units 33, the signal terminals 35-2 are connected to a switching unit (not labeled) through a two-way signal line 19. The switching unit (not labeled) includes a plurality of bidirectional switching switches 55 configured to switch the two-way signal line 19 to be connected to a temperature sampling point (not labeled) or an alternating power line 57. In the case that the two-way signal line 19 is connected to the temperature sampling point (not labeled), the switching state of the control switch 54 is configured to make the temperature detecting signal detected by the corresponding temperature detecting units 35 in each row group be sampled based on the temperature sampling point (not labeled). In the case that the two-way signal line 19 is connected to the alternating power line 57, the electrode units 33 of at least one column group are applied with the alternating electric signal based on the alternating power line 57. Details will be described below.

[0049] The multi-path ground lines 18 and the multi-path two-way signal lines 19 are conductive tracks embedded in the substrate 31. The substrate 31 is electrically connected to the first cable 15. The multi-path ground lines 18 and the multi-path two-way signal lines 19 embedded in the substrate 31 are respectively electrically connected to the corresponding conductive lines (not shown) in the first cable 15.

[0050] The tumor electric field therapy system 100 of the present embodiment includes at least one pair of the electrode sheet 13, the adapter 20 electrically connected to the electrode sheet 13, and the electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode sheet 13 and the electric field generator 30. The electric field generator 30 provides the alternating electric signal to the electrode units 33 of the electrode sheet 13 or receives the temperature detecting signal output by the corresponding temperature detecting units 35 of the electrode units 33 via the two-way signal line 19 of the adapter 20. The adapter 20 transmits the alternating electric signal generated by the electric field generator 30 to the two-way signal line 19 of the electrode sheet 13, and is further configured to receive the temperature detecting signal output by the multi-path two-way signal line 19 of the electrode sheet 13.

[0051] Reference Figure 3 and Figure 4As shown, the adapter 20 comprises a first controller 51, a plurality of groups of ADC units 52 connected to the first controller 51, a plurality of groups of voltage dividing resistors 53 and a plurality of groups of control switches 54 corresponding to the plurality of groups of ADC units 52, a plurality of groups of bidirectional switches 55 connected to the plurality of groups of ADC units 52, a first communication unit 56, a plurality of groups of alternating power lines 57 connected to the plurality of groups of bidirectional switches 55, and a first power module 58 connected to the first communication unit 56, the first controller 51 and the plurality of groups of ADC units 52, which provides DC power VCC for each electronic component of the adapter 20. The adapter 20 further comprises a plurality of circuit lines (not labeled) respectively electrically connected to the plurality of ground lines 18 and the plurality of dual-purpose signal lines 19 in the substrate 31 of each electrode sheet 13 through the first cable 15 of the corresponding electrode sheet 13. The plurality of circuit lines (not labeled) comprises a plurality of alternating power lines 57 respectively electrically connected to the plurality of dual-purpose signal lines 19 in the substrate 31 of each electrode sheet 13 and used for transmitting alternating electrical signals to the electrode sheet 13, a plurality of circuit lines (not labeled) respectively electrically connected to the plurality of dual-purpose signal lines 19 in the substrate 31 of each electrode sheet 13 and used for powering each temperature detection unit 35 of the electrode sheet 13 or transmitting temperature detection signals of the electrode sheet 13, and a plurality of circuit lines (not labeled) respectively electrically connected to the plurality of ground lines 18 in the substrate 31 of each electrode sheet 13. The number L of circuit lines electrically connected to each electrode sheet 13 is equal to the sum of the number of rows and the number of columns of the electrode units 33 of the electrode sheet 13. The number H of circuit lines electrically connected to X electrode sheets 13 is equal to X times the number of circuit lines electrically connected to a single electrode sheet 13, i.e. H = XL = X(M+N). The number of groups of control switches 54 and the number of groups of bidirectional switches 55 are both related to the number of electrode sheets 13. The number of groups of control switches 54 is equal to the number of groups of bidirectional switches 55 and is not less than the number of electrode sheets 13. Optionally, the number of groups of control switches 54 and the number of groups of bidirectional switches 55 are both equal to the number of electrode sheets 13. Hereinafter, only the electrical connection between an electrode sheet 13 with 20 electrode units 33 and the adapter 20 will be described in detail.

[0052] Each group of control switches 54 comprises a plurality of control switches 54 respectively electrically connected to the circuit lines (not labeled) corresponding to the plurality of ground lines 18 of the corresponding electrode sheet 13 and configured to control the conduction or disconnection of the plurality of ground lines 18. The circuit lines (not labeled) respectively electrically connected to the plurality of ground lines 18 of the electrode sheet 13 are grounded at one end close to the control switches 54. The number of control switches 54 in each group of control switches 54 is related to the number of ground lines 18 of the substrate 31 of the corresponding electrode sheet 13, which is equal to the number of ground lines 18 in the present embodiment. As shown in FIG. 2, the control switches 54 in each group of control switches 54 are arranged in a matrix of M rows and N columns. Figure 3 orFigure 4 As shown, in the present embodiment, the plurality of control switches 54 are respectively a first control switch 54-1, a second control switch 54-2, a third control switch 54-3 and a fourth control switch 54-4. The plurality of control switches 54 in the same group are respectively one-to-one control the closing or opening of the corresponding ground line 18 of the same electrode sheet 13. The first control switch 54-1 is used to control the closing or opening of the first ground line 18-1 of the corresponding electrode sheet 13, and in turn can be matched with the corresponding group of bidirectional switching switches 55 to control the power-on and power-off of each temperature detection unit 35 corresponding to the five electrode units 33-1 to 33-5 in the first row group 33 of the electrode sheet 13; the second control switch 54-2 is used to control the closing or opening of the second ground line 18-2 of the electrode sheet 13, and in turn can be matched with the corresponding group of bidirectional switching switches 55 to control the power-on and power-off of each temperature detection unit 35 corresponding to the five electrode units 33-6 to 33-10 in the second row group 33 of the electrode sheet 13; the third control switch 54-3 is used to control the closing or opening of the third ground line 18-3 of the electrode sheet 13, and in turn can be matched with the corresponding group of bidirectional switching switches 55 to control the power-on and power-off of each temperature detection unit 35 corresponding to the five electrode units 33-11 to 33-15 in the third row group 33 of the electrode sheet 13; the fourth control switch 54-4 is used to control the closing or opening of the fourth ground line 18-4 of the electrode sheet 13, and in turn can be matched with the corresponding group of bidirectional switching switches 55 to control the power-on and power-off of each temperature detection unit 35 corresponding to the five electrode units 33-16 to 33-20 in the fourth row group 33 of the electrode sheet 13. The above-mentioned control switch 54 can be a mechanical switch, for example, a relay. The control switch 54 can also be an electronic switch, and each control switch 54 can be operated by an additional first controller 51.

[0053] In the present embodiment, the plurality of control switches 54 in each group are electronic switches. The first controller 51 is in communication connection with the plurality of control switches 54, and is used to control the opening and closing state of the plurality of control switches 54 in each group of control switches 54 in turn and in circulation, and in turn to individually turn on each ground line 18 in the plurality of ground lines 18 of the corresponding electrode sheet 13 and cooperate with the switching of the corresponding bidirectional switching switch 55 to collect the temperature of the patient's body surface detected by all the temperature detection units 35 on the electrode sheet 13. The number of control switches 54 in each group is not less than the number of ground lines 18 of the substrate 31 of the corresponding electrode sheet 13. In the present embodiment, the number of control switches 54 in each group is the same as the number of ground lines 18 of the corresponding electrode sheet 13.

[0054] Each group of the bidirectional switch 55 is provided with a plurality of bidirectional switches 55, and the plurality of bidirectional switches 55 in each group are respectively connected into the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multiplexed dual-purpose signal lines 19 of the corresponding electrode sheet 13. The number of the bidirectional switches 55 in each group of the bidirectional switch 55 is related to the number of the dual-purpose signal lines 19 of the substrate 31 of the corresponding electrode sheet 13, and is greater than or equal to the number of the dual-purpose signal lines 19 of the substrate 31 of the corresponding electrode sheet 13, and in the embodiment, the number of the bidirectional switches 55 is equal to the number of the dual-purpose signal lines 19 of the substrate 31 of the corresponding electrode sheet 13. Each bidirectional switch 55 has a signal acquisition end 1 marked as 1 and a signal input end 2 marked as 2, the signal acquisition ends 1 of the plurality of bidirectional switches 55 in the same group are respectively electrically connected to the corresponding detection channels of the plurality of detection channels of the corresponding group of the ADC unit 52 through the temperature sampling points (not numbered), and the signal input ends 2 of each bidirectional switch 55 in the same group are electrically connected to the corresponding same alternating power supply line 57, and are configured to control the multiplexed dual-purpose signal lines 19 to be connected to the corresponding alternating power supply line 57 to transmit the alternating electrical signal or to be connected to the corresponding detection channel of the corresponding group of the ADC unit 52 to receive the temperature detection signal output by the temperature detection unit 35.

[0055] As Figure 3 or Figure 4As shown, taking the example of one electrode sheet 13 being electrically connected with the adapter 20, in the embodiment with 20 electrode units 33, the plurality of bidirectional switches 55 are respectively a first bidirectional switch 55-1, a second bidirectional switch 55-2, a third bidirectional switch 55-3, a fourth bidirectional switch 55-4, and a fifth bidirectional switch 55-5. The bidirectional switches 55 in the same group respectively control the switching of a corresponding one of the multiplexed signal lines 19 of the same electrode sheet 13 between the transmission of the alternating electrical signal and the transmission of the temperature detection signal. Specifically, the first bidirectional switch 55-1 is configured to control the switching of the first multiplexed signal line 19-1 of the corresponding electrode sheet 13 between the transmission of the alternating electrical signal and the transmission of the temperature detection signal, and further control the switching between the conduction of each of the electrode units 33-1, 33-6, 33-11, 33-16 in the first column group of the electrode sheet 13 and the conduction of the signal terminal 35-2 of each of the temperature detection units 35 corresponding to the electrode units 33-1, 33-6, 33-11, 33-16 in the first column group, and cooperate with the corresponding control switches 54-1, 54-2, 54-3, 54-4, so as to enable the first column of electrode units 33-1, 33-6, 33-11, 33-16 to transmit the alternating electrical signal to the patient or output the temperature detection signal collected by the temperature detection units 35 corresponding to the electrode units 33-1, 33-6, 33-11, 33-16 to the corresponding ADC unit 52; the second bidirectional switch 55-2 is configured to control the switching of the second multiplexed signal line 19-2 of the corresponding electrode sheet 13 between the transmission of the alternating electrical signal and the transmission of the temperature detection signal, and further control the switching between the conduction of each of the electrode units 33-2, 33-7, 33-12, 33-17 in the second column group of the electrode sheet 13 and the conduction of the signal terminal 35-2 of each of the temperature detection units 35 corresponding to the electrode units 33-2, 33-7, 33-12, 33-17 in the second column group, and cooperate with the corresponding control switches 54-1, 54-2, 54-3, 54-4, so as to enable the second column of electrode units 33-2, 33-7, 33-12, 33-17 to transmit the alternating electrical signal to the patient or output the temperature detection signal collected by the temperature detection units 35 corresponding to the electrode units 33-2, 33-7, 33-12, 33-17 to the corresponding ADC unit 52;The third bidirectional switch 55-3 is used for controlling the switching of the third dual-purpose signal line 19-3 of the corresponding electrode sheet 13 between transmitting the alternating electrical signal and transmitting the temperature detection signal, thereby controlling the switching between the conduction of each electrode unit 33 of the electrode unit 33-3, the electrode unit 33-8, the electrode unit 33-13, the electrode unit 33-18 in the third column group of the electrode sheet 13 and the conduction of the signal end 35-2 of the corresponding temperature detection unit of the electrode unit 33-3, the electrode unit 33-8, the electrode unit 33-13, the electrode unit 33-18 in the third column group, and cooperating with the corresponding control switch 54-1, the control switch 54-2, the control switch 54-3, the control switch 54-4, so that the third column electrode unit 33-3, the electrode unit 33-8, the electrode unit 33-13, the electrode unit 33-18 transmits the alternating electrical signal to the patient or outputs the temperature detection signal collected by the corresponding temperature detection unit 35 of the electrode unit 33 to the corresponding ADC unit 52; the fourth bidirectional switch 55-4 is used for controlling the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode sheet 13 between transmitting the alternating electrical signal and transmitting the temperature detection signal, thereby controlling the switching between the conduction of each electrode unit 33 of the electrode unit 33-4, the electrode unit 33-9, the electrode unit 33-14, the electrode unit 33-19 in the fourth column group of the electrode sheet 13 and the conduction of the signal end 35-2 of each temperature detection unit 35 in the fourth column group, and cooperating with the corresponding control switch 54-1, the control switch 54-2, the control switch 54-3, the control switch 54-4, so that the fourth column electrode unit 33-4, the electrode unit 33-9, the electrode unit 33-14, the electrode unit 33-19 transmits the alternating electrical signal to the patient or outputs the temperature detection signal collected by the corresponding temperature detection unit 35 of the electrode unit 33 to the corresponding ADC unit 52;The fifth bidirectional switch 55-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode sheet 13 between transmitting the alternating electrical signal and transmitting the temperature detection signal, thereby controlling the switching between the conduction of each electrode unit 33 in the fifth column group of electrode units 33-5, 33-10, 33-15, 33-20 of the electrode sheet 13 and the conduction of the signal end 35-2 of the corresponding temperature detection unit 35 of the fifth column group of electrode units 33-5, 33-10, 33-15, 33-20, and cooperating with the corresponding control switch 54-1, 54-2, 54-3, 54-4, so that the fifth column of electrode units 33-5, 33-10, 33-15, 33-20 transmits the alternating electrical signal to the patient or outputs the temperature detection signal collected by the corresponding temperature detection unit 35 of the electrode units 33 to the corresponding ADC unit 52. When the signal input end 2 of each group of bidirectional switches 55 is conductive and the signal collection end 1 is disconnected, the alternating electrical signal can be transmitted to each electrode unit 33 of the corresponding electrode sheet 13, and when the signal collection end 1 of each group of bidirectional switches 55 is conductive and the signal input end 2 is disconnected, it can be cooperated with each control switch 54 in the corresponding group of control switches 54 to transmit the temperature detection signal collected by each temperature detection unit 35 on the electrode sheet 13 in time. The bidirectional switch 55 described above can be a mechanical switch, such as a relay. The bidirectional switch 55 can also be an electronic switch, and each bidirectional switch 55 can be switched by an additional first controller 51.

[0056] In this embodiment, each group of bidirectional switches 55 is an electronic switch. The first controller 51 is in communication connection with the plurality of groups of bidirectional switches 55, and is used to control the switching of each group of bidirectional switches 55 between the signal collection end 1 and the signal input end 2, and cooperate with the closing or opening of the corresponding control switch 54, so as to continuously monitor the temperature of the patient's body surface detected by all the temperature detection units 35 on the electrode sheet 13 or transmit the alternating electrical signal to the patient.

[0057] In this embodiment, each group of ADC units 52 is electrically connected to the signal collection end 1 of each bidirectional switch 55 in the corresponding group of bidirectional switches 55 through a plurality of circuit lines (not numbered) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the plurality of dual-purpose signal lines 19 of the corresponding electrode sheet 13, and convert the temperature detection signal from an analog signal to a digital signal. Each group of ADC units 52 includes a plurality of detection channels A, B, C, D, E, each of which is used to connect a corresponding one of the plurality of dual-purpose signal lines 19 through a corresponding bidirectional switch 55. As shown in FIG. 6, the first group of ADC units 52 includes a first detection channel A, a second detection channel B, a third detection channel C, a fourth detection channel D, and a fifth detection channel E, and the second group of ADC units 52 includes a sixth detection channel A, a seventh detection channel B, an eighth detection channel C, a ninth detection channel D, and a tenth detection channel E. Figure 5 orFigure 6 As shown, each group of ADC units 52 includes 5 detection channels A, B, C, D, E, respectively, a first detection channel A, a second detection channel B, a third detection channel C, a fourth detection channel D, and a fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 through the signal collection end 1 of the first bidirectional switch 55-1, the second detection channel B is connected to the second dual-purpose signal line 19-2 through the signal collection end 1 of the second bidirectional switch 55-2, the third detection channel C is connected to the third dual-purpose signal line 19-3 through the signal collection end 1 of the third bidirectional switch 55-3, the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 through the signal collection end 1 of the fourth bidirectional switch 55-4, and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 through the signal collection end 1 of the fifth bidirectional switch 55-5. Each detection channel A, B, C, D, E is used to receive the temperature detection signal collected by the temperature detection unit 35 corresponding to the electrode unit 33 to which the corresponding dual-purpose signal line 19 is connected. In addition, each detection channel A, B, C, D, E is connected to the first power supply module 58 for providing a detection voltage to the detection channel A, B, C, D, E through a corresponding voltage dividing resistor 53 in the adapter 20. The first power supply module 58 provides a direct current.

[0058] In the present embodiment, the first communication unit 56 is configured to obtain the digital signals output by the plurality of groups of ADC units 52 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control the voltage of the alternating electric signal provided to the plurality of electrode units 33 of the electrode sheet 13 according to the received digital signals. For example, when any of the plurality of received digital signals exceeds a preset threshold value, it indicates that the temperature detected by the temperature detection unit 35 corresponding to at least one electrode unit 33 of the electrode sheet 13 exceeds a preset temperature threshold value (e.g., 41℃, 42℃, etc.), at which time the voltage of the alternating electric signal output by the electric field generator 30 can be appropriately reduced to avoid the electrode units 33 of the electrode sheet 13 from being too hot when the alternating electric signal is applied, causing a cold burn to the patient's skin. The above-mentioned preset temperature threshold value and preset threshold value can be determined according to the human safety threshold value. The first communication unit 56 is controlled by the first controller 51 and serially transmits the digital signals converted by the plurality of groups of ADC units 52. In the present embodiment, the preset temperature threshold value can be a value within 36℃-45℃.

[0059] Reference Figure 1 and Figure 1In the present embodiment, the first power module 58 is electrically connected to the second power module 32 of the electric field generator 30, and is configured to supply power to the first controller 51, the plurality of groups of ADC units 52, and the first communication unit 56 of the adapter 20. A first connector 60 is provided between each electrode sheet 13 and the adapter 20, and the first connector 60 is adapted to connect the corresponding electrode sheet 13 to the adapter 20. As shown in Figure 5 the first connector 60 includes a first plug 61 provided at the end of the first cable 15 away from the electrode sheet 13, and a first socket 62 provided on the adapter 20. The first plug 61 and the first socket 62 are press-type spring connectors, i.e., the first connector 60 connects the adapter 20 to the electrode sheet 13 in the form of a connector. Each first cable 15 has 5 wires electrically connected to the corresponding one of the bidirectional switching switches 55 in the corresponding group of bidirectional switching switches 55, and 4 wires electrically connected to the corresponding one of the control switches 54 in the corresponding group of control switches 54. That is, each first connector 60 is electrically connected to the corresponding group of bidirectional switching switches 55 and the corresponding group of control switches 54 of the adapter 20 through 9 wires, and is connected to the electric field generator 30 through the corresponding alternating power line 57 of the adapter 20.

[0060] A second connector 70 is provided between the adapter 20 and the electric field generator 30, and the second connector 70 is adapted to connect the electric field generator 30 to the adapter 20. As shown in Figure 7As shown, the adapter 20 further comprises a second cable 25 connected with a second connector 70. The second connector 70 comprises a second plug 71 arranged at an end of the second cable 25 away from the first controller 51 and a second socket 72 arranged on the electric field generator 30. The second plug 71 and the second socket 72 are press spring connectors, i.e. the second connector 70 connects the adapter 20 with the electric field generator 30 in the form of connectors. Each of the first connectors 60 such as X1, Y1, X2 and Y2 is connected with the second connector 70 through a corresponding one of the alternating power lines 57, and is further connected with a corresponding one of the control switches 54 and a corresponding one of the ADC units 52, respectively. Each of the first connectors 60 is further connected with the second connector 70 and a corresponding one of the ADC units 52 through a corresponding one of the bidirectional switching switches 55. The second cable 25 has eight conductive lines, including four conductive lines 1-4 for transmitting alternating electric signals and electrically connected with the corresponding alternating power lines 57 one by one, one conductive line 5 electrically connected with the data receiving line RX of the first communication unit 56, one conductive line 6 electrically connected with the data sending line TX of the first communication unit 56, one conductive line 7 electrically connected with the VCC power line of the first power module 58, and one conductive line 8 electrically connected with the GND line of the first power module 58. The second connector 70 is connected with the first communication unit 56 through the data receiving line RX and the data sending line TX, the VCC pin of the second connector 70 is connected with the VCC power line of the first power module 58, the GND pin of the second connector 70 is connected with the GND line of the first power module 58 and grounded, and the VCC pin of the second connector 70 is further connected with the corresponding set of the voltage dividing resistors 53 and the corresponding set of the ADC units 52 through the VCC power line of the first power module 58.

[0061] Reference Figure 3 to Figure 5 and Figure 8The electric field generator 30 comprises a second power module 32, a second controller 37, an alternating current signal generator 39, a second communication unit 38 and a group of power switches 40. The VCC pin of the second connector 70 is also electrically connected with the VCC power line of the second power module 32, and the GND pin of the second connector 70 is grounded through the GND line of the second power module 32. The second power module 32 is also connected with and supplies power to the second controller 37 and the alternating current signal generator 39. The second communication unit 38 is electrically connected with the wire 5 of the second connector 70 through its data receiving line RX and is electrically connected with the wire 6 of the second connector 70 through its data sending line TX, so as to realize information interaction between the electric field generator 30 and the adapter 20. The second controller 37 is also electrically connected with the second communication unit 38, the alternating current signal generator 39 and the group of power switches 40. The second controller 37 is configured to control the opening and closing of each power switch 40 in the group of power switches 40 and adjust the relevant parameters of the alternating electric signal applied by the alternating current signal generator 39 according to the relevant digital signal received by the second communication unit 38 from the adapter 20. The alternating current signal generator 39 is electrically connected with the wires 1 to 4 of the second connector 70 through which the alternating electric signal is transmitted, through the group of power switches 40. The group of power switches 40 comprises a plurality of power switches 40, which are arranged in one-to-one correspondence with the plurality of electrode pieces 13. Each power switch 40 is electrically connected with one wire 1, 2, 3 or 4 of the second connector 70 through which the alternating electric signal is transmitted through one alternating current power line 41-1, 41-2, 41-3 or 41-4 and is electrically connected to the corresponding electrode piece 13 through the corresponding wire 1, 2, 3 or 4 of the second connector 70, so as to deliver the alternating electric signal to each electrode piece 13. The alternating current signal generator 39 is electrically connected with the group of power switches 40 through a plurality of alternating current power lines 41. Specifically, the number of power switches 40 of the electric field generator 30 is related to the number of electrode pieces 13. In the embodiment, the number of power switches 40 is equal to the number of electrode pieces 13, and both are four. The power switches 40 comprise a first power switch 40-1, a second power switch 40-2, a third power switch 40-3 and a fourth power switch 40-4 which are electrically connected with the wires 1 to 4 of the second connector 70 in one-to-one correspondence, respectively.One end of the first power supply switch 40-1 is electrically connected with the AC signal generator 39 through the AC power line 41 of the electric field generator 30, and the other end is electrically connected with the corresponding wire 1 transmitting the alternating electric signal in the second connection 70 through an AC power line 41-1, and is electrically connected with the alternating power line 57 at the port X1 of the adapter 20 through the wire 1 of the second connector 70, the alternating power line 57 at the port X1 of the adapter 20 is electrically connected with the first connector 60, and the first connector 60 at the port X1 of the adapter 20 is electrically connected with the corresponding electrode sheet 13, so as to control whether the AC signal generator 39 delivers the alternating electric signal to the electrode sheet 13 electrically connected to the port X1 of the adapter 20; one end of the second power supply switch 40-2 is electrically connected with the AC signal generator 39 through the AC power line 41 of the electric field generator 30, and the other end is electrically connected with the corresponding wire 2 transmitting the alternating electric signal in the second connection 70 through an AC power line 41-2, and is electrically connected with the alternating power line 57 at the port Y1 of the adapter 20 through the wire 2 of the second connector 70, the alternating power line 57 at the port Y1 of the adapter 20 is electrically connected with the first connector 60, and the first connector 60 at the port Y1 of the adapter 20 is electrically connected with the corresponding electrode sheet 13, so as to control whether the AC signal generator 39 delivers the alternating electric signal to the electrode sheet 13 electrically connected to the port Y1 of the adapter 20; one end of the third power supply switch 40-3 is electrically connected with the AC signal generator 39 through the AC power line 41 of the electric field generator 30, and the other end is electrically connected with the corresponding wire 3 transmitting the alternating electric signal in the second connection 70 through an AC power line 41-3, and is electrically connected with the alternating power line 57 at the port X2 of the adapter 20 through the wire 3 of the second connector 70, the alternating power line 57 at the port X2 of the adapter 20 is electrically connected with the first connector 60, and the first connector 60 at the port X2 of the adapter 20 is electrically connected with the corresponding electrode sheet 13, so as to control whether the AC signal generator 39 delivers the alternating electric signal to the electrode sheet 13 electrically connected to the port X2 of the adapter 20; one end of the fourth power supply switch 40-4 is electrically connected with the AC signal generator 39 through the AC power line 41 of the electric field generator 30, and the other end is electrically connected with the corresponding wire 4 transmitting the alternating electric signal in the second connection 70 through an AC power line 41-4, and is electrically connected with the alternating power line 57 at the port Y2 of the adapter 20 through the wire 4 of the second connector 70, the alternating power line 57 at the port Y2 of the adapter 20 is electrically connected with the first connector 60, and the first connector 60 at the port Y2 of the adapter 20 is electrically connected with the corresponding electrode sheet 13, so as to control whether the AC signal generator 39 delivers the alternating electric signal to the electrode sheet 13 electrically connected to the port Y1 of the adapter 20.

[0062] The working principle of the tumor electric field treatment system 100 of the embodiment will be described in detail below. Figure 9 The working principle of the tumor electric field treatment system 100 of the embodiment will be described in detail below.

[0063] Specifically, when the temperature at each electrode unit 33 of a certain electrode sheet 13 needs to be detected, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal collection end 1 of each of the plurality of bidirectional switch 55 of the group of bidirectional switch 55 electrically connected to the electrode sheet 13 to be conductive, and the signal input end 2 to be disconnected, so as to disconnect the alternating electric signal applied to the electrode sheet 13; at the same time, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls each control switch 54 of the group of control switch 54 electrically connected to the electrode sheet 13 to be sequentially and time-sharing conductive, at this time, the temperature detection signal collected by each temperature detection unit 35 corresponding to each electrode unit 33 of each row group of the electrode sheet 13 can be sequentially and time-sharing collected by each detection channel A, B, C, D, E of the group of ADC unit 52 corresponding to the electrode sheet 13. Each detection channel A, B, C, D, E of each group of ADC unit 52 only collects the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13 located in the same row group at the same time, and the above temperature detection signal can be characterized by voltage value. Only one control switch 54 of the four control switches 54 of the group of control switch 54 corresponding to the electrode sheet 13 can be conductive at the same time, and the other three control switches 54 are disconnected. The five bidirectional switch 55 of the group of bidirectional switch 55 corresponding to the group of ADC unit 52 are all switched to the signal collection end 1 to make each two-purpose signal line 19 of the electrode sheet 13 and the corresponding detection channel A, B, C, D, E of the corresponding ADC unit 52 one-to-one corresponding electrically connected and conductive. In this way, the group of ADC unit 52 can collect the voltage value of all temperature detection units 35 corresponding to each electrode unit 33 in the same row group short-circuited by the conductive control switch 54.

[0064] Specifically, when the control switch 54-1 is closed, the control switch 54-2, the control switch 54-3 and the control switch 54-4 are all opened, and the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4 and the fifth bidirectional switch 55-5 are all switched to the signal collection end 1, the temperature detection units 35 corresponding to the electrode units 33-1 to 33-5 of the first row group are powered on, the temperature detection units 35 corresponding to the electrode units 33-6 to 33-20 of the remaining row groups are powered off, the signal ends 35-2 of the temperature detection units 35 corresponding to the electrode units 33-1, 33-6, 33-11 and 33-16 on the first detection channel A of the ADC unit 52 are shorted, only the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-1 is connected to the ground, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, so the resistance of the temperature detection unit 35 corresponding to the electrode unit 33-1 is not affected, and only the temperature detection unit 35 corresponding to the electrode unit 33-1 on the first detection channel A of the ADC unit 52 works effectively, and the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-1. Similarly, the voltage value collected by the second detection channel B of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-2. The voltage value collected by the third detection channel C of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-3. The voltage value collected by the fourth detection channel D of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-4. The voltage value collected by the fifth detection channel E of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-5.

[0065] When the control switch 54-2 is closed, the control switch 54-1, the control switch 54-3 and the control switch 54-4 are all open, and the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4 and the fifth bidirectional switch 55-5 are all switched to the signal collection end 1, the electrode unit 33-6 to the electrode unit 33-10 of the second row group are powered on, the electrode unit 33-1 to the electrode unit 33-5 and the electrode unit 33-11 to the electrode unit 33-20 of the remaining row groups are powered off, the signal end 35-2 of the temperature detection unit 35 corresponding to each of the electrode unit 33-1, the electrode unit 33-6, the electrode unit 33-11 and the electrode unit 33-16 on the first detection channel A of the ADC unit 52 is shorted, only the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-6 is connected to the ground, the ground end 35-1 of the temperature detection unit 35 corresponding to each of the electrode unit 33-1, the electrode unit 33-11 and the electrode unit 33-16 is disconnected, each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, and the resistance of the temperature detection unit 35 corresponding to the electrode unit 33-6 is not affected, so only the temperature detection unit 35 corresponding to the electrode unit 33-6 on the first detection channel A of the ADC unit 52 works effectively, at this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-6. Similarly, the voltage value collected by the second detection channel B of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-7. The voltage value collected by the third detection channel C of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-8. The voltage value collected by the fourth detection channel D of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-9. The voltage value collected by the fifth detection channel E of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-10.

[0066] When the control switch 54-3 is closed, the control switch 54-1, the control switch 54-2 and the control switch 54-4 are all open, and the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4 and the fifth bidirectional switch 55-5 are all switched to the signal collection end 1, the electrode unit 33-11 to the electrode unit 33-15 of the third row group are powered on, the electrode unit 33-1 to the electrode unit 33-10 and the electrode unit 33-16 to the electrode unit 33-20 of the remaining row groups are powered off, the signal end 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33-1, the electrode unit 33-6, the electrode unit 33-11 and the electrode unit 33-16 on the first detection channel A of the ADC unit 52 is short-circuited, only the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-11 is connected to the ground, the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-1, the electrode unit 33-6 and the electrode unit 33-16 is disconnected, each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, and the resistance value of the temperature detection unit 35 corresponding to the electrode unit 33-11 is not affected, so only the temperature detection unit 35 corresponding to the electrode unit 33-11 works effectively on the first detection channel A of the ADC unit 52, at this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-11. Similarly, the voltage value collected by the second detection channel B of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-12. The voltage value collected by the third detection channel C of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-13. The voltage value collected by the fourth detection channel D of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-14. The voltage value collected by the fifth detection channel E of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-15.

[0067] When the control switch 54-4 is closed, the control switch 54-1, the control switch 54-2 and the control switch 54-3 are all open, and the first bidirectional switch 55-1, the second bidirectional switch 55-2, the third bidirectional switch 55-3, the fourth bidirectional switch 55-4 and the fifth bidirectional switch 55-5 are all switched to the signal collection end 1, the corresponding temperature detection unit 35 of the electrode unit 33-16 to the electrode unit 33-20 in the fourth row group is powered on, and the corresponding temperature detection unit 35 of the electrode unit 33-1 to the electrode unit 33-15 in the remaining row groups is powered off. The signal end 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33-1, the electrode unit 33-6, the electrode unit 33-11 and the electrode unit 33-16 on the first detection channel A of the ADC unit 52 is short-circuited. Since only the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-16 is connected to the ground, and the ground end 35-1 of the temperature detection unit 35 corresponding to the electrode unit 33-1, the electrode unit 33-6 and the electrode unit 33-11 is disconnected, and each temperature detection unit 35 includes a temperature sensor 34 and a diode 36 connected in series with the temperature sensor 34, the resistance of the temperature detection unit 35 corresponding to the electrode unit 33-16 is not affected. Therefore, only the temperature detection unit 35 corresponding to the electrode unit 33-16 works effectively on the first detection channel A of the ADC unit 52. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-16. Similarly, the voltage value collected by the second detection channel B of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-17. The voltage value collected by the third detection channel C of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-18. The voltage value collected by the fourth detection channel D of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-19. The voltage value collected by the fifth detection channel E of the ADC unit 52 is the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-20.

[0068] Thus, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 can collect the temperature detection signals of the temperature detection units 35 corresponding to all the electrode units 33 of an electrode sheet 13 by controlling the group of bi-directional switching switches 55 and the group of control switches 54 electrically connected to the electrode sheet 13. That is, the switching unit (not numbered) is configured to switch the two-purpose signal lines 19 corresponding to at least two column groups to be connected to the corresponding temperature sampling points (not numbered) at the same time, and the temperature detection signals detected by the corresponding temperature detection units 35 in each row group are sampled based on the corresponding temperature sampling points (not numbered) by configuring the switching state of the corresponding control switches 54. Similarly, the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 of the other electrode sheets 13 can be obtained.

[0069] The first controller 51 or the second controller 37, the groups of ADC units 52 and the groups of bi-directional switching switches 55 can automatically perform operations by pre-programmed program codes. For example, the first controller 51 or the second controller 37 first controls all the bi-directional switching switches 55 in the corresponding group of bi-directional switching switches 55 to be switched to the signal collection end 1 so that the signal collection end 1 of the bi-directional switching switches 55 is all turned on and the signal input end 2 is all turned off, so that the two-purpose signal lines 19 of the corresponding electrode sheet 13 are electrically connected to the corresponding group of ADC units 52. Then, the control switch 54-1 in the corresponding group of control switches 54 is closed, and the remaining control switches 54-2 to 54-4 in the group of control switches 54 are opened. During this period, the detection channels A, B, C, D and E of the group of ADC units 52 acquire the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 in the first row group of the corresponding electrode sheet 13, convert them into digital signals, and store them in the additionally provided memory. Then, after a preset interval, the first controller 51 or the second controller 37 closes the control switch 54-2 in the group of control switches 54, and opens the control switch 54-1, the control switch 54-3 and the control switch 54-4 in the group of control switches 54. During this period, the detection channels A, B, C, D and E of the group of ADC units 52 acquire the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 in the second row group. In this way, each control switch 54 in the group of control switches 54 is sequentially and individually turned on, and the temperature detection signals of all the temperature detection units 35 on the electrode sheet 13 can be obtained. Similarly, the temperature detection signals of all the temperature detection units 35 on at least one pair of electrode sheets 13 can be obtained by such operations.

[0070] It should be noted that in other embodiments, the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 of a column group can also be sampled in the same temperature sampling period by controlling the group of bidirectional switching switches 55 and the group of control switches 54 electrically connected to the electrode sheet 13 through the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30. For example, when only the first bidirectional switching switch 55-1 is switched to the signal sampling end 1, the control switch 54-1 can be controlled to be closed, and the control switch 54-2, the control switch 54-3, and the control switch 54-4 are all opened, at this time, only the temperature detection units 35 corresponding to the electrode units 33-1 of the first row group are powered on, the signal end 35-2 of the temperature detection unit 35 corresponding to the electrode unit 33-1 is short-circuited on the first detection channel A of the group of ADC units 52, and therefore the group of ADC units 52 will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-1; then, the control switch 54-2 is controlled to be closed, and the control switch 54-1, the control switch 54-3, and the control switch 54-4 are all opened, at this time, the group of ADC units 52 will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-6; then, the control switch 54-3 is controlled to be closed, and the control switch 54-1, the control switch 54-2, and the control switch 54-4 are all opened, at this time, the group of ADC units 52 will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-11; finally, the control switch 54-4 is controlled to be closed, and the control switch 54-1, the control switch 54-2, and the control switch 54-3 are all opened, at this time, the group of ADC units 52 will detect the voltage value of the temperature detection unit 35 corresponding to the electrode unit 33-16. Thus, in the same sampling period, only the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 of a column group can be sampled. Similarly, in other sampling periods, the temperature detection signals of the temperature detection units 35 corresponding to the electrode units 33 of other column groups can be sampled. That is, the switching unit (not numbered) is configured to switch the two-purpose signal lines 19 corresponding to each column group to be connected to the corresponding temperature sampling points (not numbered) respectively, and the switching states of the control switches 54 are configured to make the temperature detection signals detected by each temperature detection unit 35 in each column group be sampled respectively. It should be noted that in other embodiments, the temperature detection signals of the temperature detection units 35 corresponding to two column groups, three column groups, or four column groups of electrode units 33 can also be sampled in the same sampling period, which will not be described here in detail.

[0071] Specifically, when it is required to apply an alternating electric signal to each electrode unit 33 of a certain electrode sheet 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input end 2 of each of the plurality of bidirectional switching switches 55 of the group of bidirectional switching switches 55 electrically connected to the electrode sheet 13 to be conductive, the signal collection end 1 to be non-conductive, and controls one of the power supply switches 40 electrically connected to the electrode sheet 13 to be conductive, at this time, the second controller 37 of the electric field generator 30 controls the alternating signal generator 39 to apply an alternating electric signal to each electrode unit 33 of the electrode sheet 13 through the alternating power supply line 57, and the voltage or current of the applied alternating electric signal is adjustable. That is, the switching unit (not numbered) is configured to switch the two-purpose signal line 19 corresponding to at least two column groups to be connected to the alternating power supply line 57 at the same time, so that the electrode units 33 of the at least two column groups are simultaneously applied with an alternating electric signal based on the alternating power supply line 57.

[0072] It should be noted that in other embodiments, the application of an alternating electric signal to part of the electrode units 33 of a certain electrode sheet 13 at the same time period can also be realized by the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controlling the group of bidirectional switching switches 55 electrically connected to the electrode sheet 13. For example, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the signal input end 2 of the first bidirectional switching switch 55-1 of the plurality of bidirectional switching switches 55 of the group of bidirectional switching switches 55 electrically connected to the electrode sheet 13 to be conductive, the signal collection end 1 to be non-conductive, and controls one of the power supply switches 40 electrically connected to the electrode sheet 13 to be conductive, at this time, the second controller 37 of the electric field generator 30 controls the alternating signal generator 39 to apply an alternating electric signal to the first column group of electrode units 33-1, electrode units 33-6, electrode units 33-11, electrode units 33-16 of the electrode sheet 13 through the alternating power supply line 57, and the voltage or current of the applied alternating electric signal is adjustable. That is, the switching unit (not numbered) is configured to switch the two-purpose signal line 19 corresponding to each column group to be connected to the alternating power supply line 57 respectively, so that the electrode units 33 of each column group are simultaneously applied with an alternating electric signal based on the alternating power supply line 57. It should be noted that in other embodiments, two column groups, three column groups or four column groups of electrode units 33 can also be simultaneously applied with an alternating electric signal at the same time period, which will not be described in detail here.

[0073] It should be noted that the control switch 54 electrically connected with the multi-path ground wire 18 of the electrode sheet 13 and the bidirectional switch 55 electrically connected with the multi-path dual-purpose signal line 19 of the electrode sheet 13 are both arranged in the adapter 20, but in other embodiments, the control switch 54 electrically connected with the ground wire 18 and the bidirectional switch 55 electrically connected with the dual-purpose signal line 19 can also be arranged on the electrode sheet 13 or in the electric field generator 30, which will not be described here. In addition, the ADC unit 52 arranged in the adapter 20 can also be arranged in the electric field generator 30 and directly controlled by the second controller 37.

[0074] The tumor electric field treatment system 100 of the present application can realize real-time and comprehensive monitoring of the temperature of all electrode units 33 on the electrode sheet 13 without increasing the weight of the electrode sheet 13 and the core of the first cable 15 electrically connected with the electrode sheet 13, and then the obtained temperature detection signal can be used to judge whether the electrode sheet 13 is qualified; or the obtained temperature detection signal can be used to judge whether the temperature detection unit 35 of the electrode sheet 13 is faulty or abnormal, and whether the electrode sheet 13 needs to be replaced based on the number of faulty or abnormal temperature detection units 35 obtained; or the electrode sheet type can be identified according to the obtained temperature detection signal when the electrode sheet is qualified; or the electrode units 33 of the electrode sheet 13 can be judged for over-temperature condition according to the obtained temperature detection signal when the electrode sheet is qualified, and then the alternating electric signal applied to the electrode sheet 13 or the corresponding column electrode units 33 of the electrode sheet 13 is controlled to avoid patient body surface low-temperature burns during tumor treatment by the electrode sheet 13. In addition, the substrate 31 of the electrode sheet 13 of the present application is electrically connected with the same electrode unit 33 and the signal end 35-2 of the corresponding temperature detection unit 35 through the same dual-purpose signal line 19, which not only realizes the transmission of alternating electric signal and direct current electric signal for temperature signal acquisition and the acquired temperature detection signal through the dual-purpose signal line 19, but also greatly reduces the number of conductive traces (ground wire 18, dual-purpose signal line 19) arranged thereon, reduces the wiring difficulty of the substrate 31, simplifies the manufacturing process, and also reduces the weight and manufacturing cost of the substrate 31. The electrode sheet 13 of the present application can also realize switching between alternating electric signal for tumor treatment and direct current electric signal for temperature acquisition and the acquired temperature detection signal through the combination control of the control switch 54 electrically connected with the ground wire 18 and the bidirectional switch 55 electrically connected with the dual-purpose signal line 19.

[0075] Specifically, when it is required to apply an alternating electric signal to the patient through each electrode unit 33 of a certain electrode sheet 13, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls all the control switches 54 in the group of control switches 54 corresponding to the electrode sheet 13 to be turned off, and controls all the bidirectional switching switches 55 in the group of bidirectional switching switches 55 corresponding to the electrode sheet 13 to be switched to the signal input end 2, so that the signal collection end 1 of the bidirectional switching switches 55 is turned off and the signal input end 2 is turned on, realizing that each two-purpose signal line 19 of the electrode sheet 13 is electrically connected to an alternating power line 57 corresponding to the electrode sheet 13 of the adapter 20, so that the alternating electric signal is transmitted to each electrode unit 33 of the electrode sheet 13.When the temperature detection signal of the temperature detection unit 35 corresponding to all the electrode units 33 of the electrode sheet 13 detected is far below the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the alternating current signal generator 39 to continue generating the alternating electric signal with the increasing voltage or current amplitude or the unchanged voltage or current amplitude through the second controller 37, and then transmits the alternating electric signal to the corresponding pair of electrode sheets 13 through the corresponding alternating power line 57 of the adapter 20, so that the pair of electrode sheets 13 continues to apply the alternating electric signal; when the temperature detection signal of the temperature detection unit 35 corresponding to all the electrode units 33 of the electrode sheet 13 detected is below but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 can reduce the voltage or current of the alternating electric signal generated by the alternating current signal generator 39 through the second controller 37, and then reduce the voltage or current of the alternating electric signal applied to the pair of electrode sheets 13; when it is detected that the temperature detection signal of the temperature detection unit 35 corresponding to an electrode unit 33 of a certain electrode sheet 13 is greater than the preset temperature threshold, the electric field generator 30 controls the power supply switch 40 electrically connected with the electrode sheet 13 to be disconnected through the second controller 37, so as to stop applying the alternating electric signal to the electrode sheet 13; or the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls all the bidirectional switching switches 55 in the group of bidirectional switching switches 55 electrically connected with the electrode sheet 13 to switch from the signal input end 2 to the signal collection end 1, that is, controls all the bidirectional switching switches 55 in the group of bidirectional switching switches 55 electrically connected with the electrode sheet 13 to be all turned on at the signal collection end 1 and all disconnected at the signal input end 2, so as to stop applying the alternating electric signal to the electrode sheet 13; or, when it is detected that the temperature detection signal of the temperature detection unit 35 corresponding to an electrode unit 33 of a certain electrode sheet 13 is greater than the preset temperature threshold, the second controller 37 of the electric field generator 30 controls the power supply switch 40 electrically connected with the electrode sheet 13 to continue to be turned on, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 controls a bidirectional switching switch 55 electrically connected with the electrode unit 33 of the electrode sheet 13 to switch from the signal input end 2 to the signal collection end 1, and the second controller 37 of the electric field generator 30 or the first controller 21 of the adapter 20 simultaneously controls the remaining bidirectional switching switches 55 electrically connected with the electrode units 33 whose temperature detection signals do not exceed the preset temperature threshold and with the electrode units 33 whose temperature detection signals exceed the preset temperature threshold and are in different columns to continue to be electrically connected with the respective signal input end 2, so as to stop applying the alternating electric signal to all the electrode units 33 in the column where the electrode unit 33 whose temperature detection signal exceeds the preset temperature threshold is located, and continue to apply the alternating electric signal to the remaining column electrode units 33 whose temperature detection signals do not exceed the preset temperature threshold.Thus, the tumor electric field treatment system 100 realizes the alternating electric signal application control method based on the temperature detection signal.

[0076] The electrode sheet temperature detection method provided by the embodiments of the present application is applied to the electrode sheet 13 or the tumor electric field treatment system 100, and refers to FIG. 1, which includes the following steps. Figure 10

[0077] Step 210: Control the switching unit to connect the two-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 to the corresponding temperature sampling point.

[0078] Specifically, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to disconnect the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13 and connect the direct current electric signal applied to the signal end 35-2 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13.

[0079] Further, the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch from the end electrically connected to the alternating electric signal to the end electrically connected to the direct current electric signal, that is, the bidirectional switching switch 55 electrically connected to the electrode sheet 13 is controlled to switch from the signal input end 2 to the signal collection end 1; or the bidirectional switching switch 55 electrically connected to each electrode unit 33 of the electrode sheet 13 is controlled to switch from the on state to the off state of each electrode unit 33 of the electrode sheet 13 and switch from the off state to the on state of the signal end 35-2 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13.

[0080] Step 220: Control the control switch 54 corresponding to each row group to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point.

[0081] Specifically, the control switch 54 electrically connected to the ground end 35-1 of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13 is sequentially turned on in time sequence to obtain the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 of the electrode sheet 13.

[0082] In some embodiments, in the case that the two-purpose signal line 19 corresponding to each column group is connected to the corresponding temperature sampling point, the control switch 54 corresponding to each row group is controlled, including: controlling the control switch 54 corresponding to each row group to be closed in sequence to sample the analog temperature signal of each electrode unit 33 in each column group.

[0083] ​In some embodiments, the control switch 54 corresponding to each row group is controlled in the case that the two-purpose signal line 19 corresponding to at least two column groups is connected to the corresponding temperature sampling point at the same time, including: controlling the control switch 54 corresponding to each row group to be closed in turn, so as to sample the analog temperature signal of the corresponding electrode unit 33 in each row group respectively.

[0084] The electrode sheet temperature detection method provided by the present application can quickly and accurately obtain the temperature of all electrode units of the electrode sheet; and can determine whether the temperature detection unit of the electrode sheet is faulty, abnormal, or qualified, or needs to be replaced according to the obtained temperature detection signals of all temperature detection units of the electrode sheet; can also determine whether each electrode unit of the electrode sheet is over-temperature according to the obtained temperature detection signals of all temperature detection units of the electrode sheet in the case that each temperature detection unit of the electrode sheet is normal, and further control the alternating electric signal applied to the electrode sheet or each electrode unit of the electrode sheet; and can also perform electrode sheet type identification in the case that the temperature detection signals of each temperature detection unit of the electrode sheet are normal.

[0085] The first controller 51 in the adapter 20 of the tumor electric field treatment system 100 or the electric field generator 30 is provided with a preset threshold, a first preset temperature, a second preset temperature, and a preset temperature threshold, wherein the first preset temperature is lower than the second preset temperature, and the second preset temperature is lower than the preset temperature threshold.

[0086] Referring to Figure 11 The present application further provides an electrode sheet temperature abnormality detection method, including the following steps:

[0087] Step 210: control the switching unit to connect the two-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 to the corresponding temperature sampling point.

[0088] Step 220: control the control switch 54 corresponding to each row group to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal at each electrode unit 33 in each electrode sheet 13.

[0089] Step 230: determine whether the electrode sheet 13 is abnormal according to the temperature detection signal.

[0090] In some embodiments, the step of determining whether the electrode sheet 13 is abnormal according to the temperature detection signal in step 230 specifically includes the following steps:

[0091] Step 231: comparing the temperature at each electrode unit 33 in the corresponding electrode sheet 13 with a preset temperature threshold according to the temperature detection signal. Specifically, the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 can be compared with the preset temperature threshold.

[0092] Step 232: judging whether the temperature of the electrode sheet 13 is abnormal according to the comparison result. Specifically, whether the temperature of each electrode unit 33 in the electrode sheet 13 is abnormal is judged according to the comparison result.

[0093] The comparison result in step 232 includes not exceeding the preset temperature threshold and exceeding the preset temperature threshold. Not exceeding the preset temperature threshold includes being far below the preset temperature threshold and being close to the preset temperature threshold. The preset temperature threshold is 40-42°C. Optionally, the preset temperature threshold is 40.5-41.5°C. Optionally, the preset temperature threshold is 41-41.5°C. Optionally, the preset temperature threshold is 41°C.

[0094] The process of judging whether the temperature of the electrode sheet 13 is abnormal according to the comparison result in step 232 is specifically as follows: in the case that the temperature at any one of the electrode units 33 in the corresponding electrode sheet 13 exceeds the preset temperature threshold, it is determined that the temperature of the electrode sheet 13 is abnormal. In the case that the temperature at all the electrode units 33 in the corresponding electrode sheet 13 does not exceed the preset temperature threshold, it is determined that the temperature of the electrode sheet 13 is not abnormal.

[0095] In other embodiments, the step of judging whether the electrode sheet 13 is abnormal according to the temperature detection signal in step 230 specifically includes the following steps:

[0096] Step 233: determining that the electrode sheet 13 is unqualified in the case that any one of the electrode units 33 in the corresponding electrode sheet 13 is abnormal or fails according to the temperature detection signal.

[0097] Specifically, whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or fails is judged according to the temperature detection signal detected by the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13; and then whether the electrode sheet 13 is qualified is judged according to whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or fails. When the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or fails, it is determined that the electrode sheet 13 is unqualified; when the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is not abnormal or does not fail, it is determined that the electrode sheet 13 is qualified.

[0098] In some embodiments, the step of determining whether the electrode sheet 13 is abnormal according to the temperature detection signal in step 230 specifically comprises the following steps:

[0099] Step 234: In the case that the abnormal or malfunctioning electrode unit 33 is determined in the corresponding electrode sheet 13 according to the temperature detection signal, the number of abnormal or malfunctioning electrode units 33 is determined.

[0100] Step 235: In the case that the number of abnormal or malfunctioning electrode units 33 reaches a preset threshold, it is determined that the electrode sheet 13 needs to be replaced.

[0101] Specifically, it is determined whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning according to the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 obtained; and then it is determined whether the electrode sheet 13 needs to be replaced according to whether the temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13 is abnormal or malfunctioning.

[0102] For example, when the number of abnormal or malfunctioning temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 exceeds a preset threshold, it is determined that the electrode sheet 13 needs to be replaced; when the number of abnormal or malfunctioning temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13 does not exceed the preset threshold, it is determined that the electrode sheet 13 does not need to be replaced. The preset threshold is 20% of the total number of temperature detection units 35 of the electrode sheet 13.

[0103] Referring to FIG. 1, Figure 12 The present application also provides a control method of a tumor electric field treatment system, which comprises the following steps:

[0104] Step 210: The switching unit is controlled so that the two-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 is connected to the corresponding temperature sampling point.

[0105] Step 220: The control switch 54 corresponding to each row group is controlled so as to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0106] Step 240: The alternating electric signal strength applied to the electrode unit 33 is controlled according to the temperature detection signal.

[0107] Specifically, in the case that the electrode sheet 13 is determined not to be replaced, the alternating electric signal applied to each electrode unit 33 in the electrode sheet 13 is controlled or adjusted according to the temperature detection signals detected by the temperature detection units 35 corresponding to each electrode unit 33 in the electrode sheet 13. That is, steps 234-235 can be added between step 240 and step 220.

[0108] In some embodiments, the controlling of the strength of the alternating electric signal applied to the electrode unit 33 according to the temperature detection signal in step 240 specifically comprises the following steps:

[0109] Step 241: comparing the temperature at each electrode unit 33 in the electrode sheet 13 with a preset temperature threshold according to the temperature detection signal.

[0110] Step 242: controlling the strength of the alternating electric signal according to the comparison result.

[0111] In some embodiments, the controlling of the strength of the alternating electric signal according to the comparison result in step 242 specifically comprises:

[0112] Step 2421: stopping the application of the alternating electric signal to the electrode units 33 of the electrode sheet 13 in the case that the temperature at at least one electrode unit 33 exceeds the preset temperature threshold. Specifically, the application of the alternating electric signal to the electrode units 33 of the electrode sheet 13 is stopped when there is a temperature detection signal exceeding the preset temperature threshold among the temperature detection signals of all the electrode units 33 of the electrode sheet 13. While the application of the alternating electric signal to each electrode unit 33 of the electrode sheet 13 is continued when none of the temperature detection signals of the electrode units 33 of the electrode sheet 13 exceeds the preset temperature threshold.

[0113] In some embodiments, the stopping of the application of the alternating electric signal to the electrode units 33 of the electrode sheet 13 in step 2421 specifically comprises: stopping the application of the alternating electric signal to all the electrode units 33 of the electrode sheet 13; or stopping the application of the alternating electric signal to all the electrode units 33 in the column group in which the electrode unit 33 exceeding the preset temperature threshold is located.

[0114] Further, in the case that the application of the alternating electric signal to all the electrode units 33 in the column group in which the electrode unit 33 exceeding the preset temperature threshold is located is stopped, the application of the alternating electric signal to the electrode units 33 in other column groups of the electrode sheet 13 is continued. The strength of the alternating electric signal applied to the electrode units 33 in other column groups of the electrode sheet 13 can be adjusted. For example, all the electrode units 33 in which the temperature detection signal does not exceed the preset temperature threshold and which are in different columns from the electrode unit 33 in which the temperature detection signal exceeds the preset temperature threshold are continued to be applied with the alternating electric signal, and the signal can be adjusted.

[0115] In some embodiments, the controlling the alternating electric signal strength according to the comparison result in step 242 specifically comprises:

[0116] Step 2422: If the temperature at all the electrode units 33 in the electrode sheet 13 does not exceed the first preset temperature which is less than the preset temperature threshold, increasing the alternating electric signal strength applied to the electrode units 33 in the electrode sheet 13, in the case that the temperature at all the electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold.

[0117] In step 2422, the electric field strength of each column group to which the alternating electric signal strength is increased increases by the same amount.

[0118] Step 2423: If the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the first preset temperature and is less than the second preset temperature, maintaining the alternating electric signal strength applied to the electrode units 33 in the electrode sheet 13 unchanged, in the case that the temperature at all the electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold.

[0119] Step 2424: If the temperature at at least one electrode unit 33 in the electrode sheet 13 exceeds the second preset temperature which is greater than the first preset temperature and is less than the preset temperature threshold, decreasing the alternating electric signal strength applied to the electrode units 33 in the electrode sheet 13, in the case that the temperature at all the electrode units 33 in the electrode sheet 13 does not exceed the preset temperature threshold.

[0120] In step 2424, the electric field strength of each column group to which the alternating electric signal strength is decreased decreases by the same amount.

[0121] For example, when the temperature detection signal is far below the preset temperature threshold, the alternating electric signal is continuously applied to the electrode units 33 in the electrode sheet 13 in a manner of increasing the voltage or current amplitude of the alternating electric signal applied to the electrode units 33 in the electrode sheet 13, or in a manner of maintaining the voltage or current amplitude of the alternating electric signal applied to the electrode units 33 in the electrode sheet 13 unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electric signal is continuously applied to the electrode units 33 in the electrode sheet 13 in a manner of maintaining the voltage or current amplitude of the alternating electric signal applied to the electrode units 33 in the electrode sheet 13 unchanged, or in a manner of decreasing the voltage or current amplitude of the alternating electric signal applied to the electrode units 33 in the electrode sheet 13.

[0122] In some embodiments, the controlling the alternating electric signal strength according to the comparison result in step 242 specifically comprises:

[0123] Step 2425: In the case that the temperature at the at least one electrode unit 33 exceeds the preset temperature threshold, determine the number of over-temperature column groups.

[0124] Step 2426: In the case that the number of over-temperature column groups exceeds the preset number threshold, stop applying the alternating electric signal to all electrode units 33 of the electrode sheet 13.

[0125] Step 2427: In the case that the number of over-temperature column groups does not exceed the preset number threshold, stop applying the alternating electric signal to all electrode units 33 of the column group in which the electrode unit 33 exceeding the preset temperature threshold is located.

[0126] Further, in the case that the alternating electric signal is stopped from being applied to all electrode units 33 of the column group in which the electrode unit 33 exceeding the preset temperature threshold is located, the alternating electric signal continues to be applied to the electrode units 33 of other column groups in the electrode sheet 13. The intensity of the alternating electric signal applied to the electrode units 33 of other column groups in the electrode sheet 13 is adjustable.

[0127] Step 2428: In the case that the number of over-temperature column groups does not exceed the preset number threshold, if the temperature at each electrode unit 33 in the non-over-temperature column group does not exceed a first preset temperature, increase the intensity of the alternating electric signal applied to the electrode units 33 of the non-over-temperature column group, wherein the first preset temperature is less than the preset temperature threshold.

[0128] In step 2428, the alternating electric signal intensity of each column group corresponding to the increased intensity has the same increased amplitude of the electric field strength.

[0129] Step 2429: In the case that the number of over-temperature column groups does not exceed the preset number threshold, if there is at least one electrode unit 33 in the non-over-temperature column group whose temperature exceeds the first preset temperature and is less than the preset temperature threshold, keep the intensity of the alternating electric signal currently applied to the electrode units 33 of the non-over-temperature column group unchanged.

[0130] Step 2430: In the case that the number of over-temperature column groups does not exceed the preset number threshold, if there is at least one electrode unit 33 in the non-over-temperature column group whose temperature exceeds a second preset temperature and is less than the preset temperature threshold, decrease the intensity of the alternating electric signal applied to the electrode units 33 of the non-over-temperature column group, wherein the second preset temperature is greater than the first preset temperature and less than the preset temperature threshold.

[0131] In step 2430, the alternating electric signal intensity of each column group corresponding to the decreased intensity has the same decreased amplitude of the electric field strength.

[0132] For example, when the temperature detection signal is far below the preset temperature threshold, the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13 is continuously applied in a manner of increasing the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13, or in a manner of keeping the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13 unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13 is continuously applied in a manner of keeping the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13 unchanged, or in a manner of reducing the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33 of the electrode sheet 13.

[0133] Referring to Figure 13 As shown in the drawings, the present application also provides an electrode sheet type identification method, which comprises the following steps:

[0134] Step 210: Control the switching unit to connect the two-purpose signal line 19 corresponding to at least one column group in the corresponding electrode sheet 13 to the corresponding temperature sampling point.

[0135] Step 220: Control the control switch 54 corresponding to each row group to sample the analog temperature signal of the corresponding electrode unit 33 based on the corresponding temperature sampling point, so as to determine the temperature detection signal of each electrode unit 33 in each electrode sheet 13.

[0136] Step 250: Identify the type of the electrode sheet 13 according to the temperature detection signal.

[0137] Specifically, in the case that the electrode sheet 13 is qualified or each temperature detection unit 35 in the electrode sheet 13 is normal or does not appear to be faulty, the type of the electrode sheet 13 is identified according to the temperature detection signal detected by each temperature detection unit 35 corresponding to each electrode unit 33 in the electrode sheet 13.

[0138] The present application also provides a signal control method for tumor electric field treatment, which is used for the tumor electric field treatment system 100 or the electrode sheet 13 described above, and the method comprises: combined control of the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 between applying an alternating electric signal and collecting a temperature detection signal.

[0139] Referring to Figure 14 As shown in the drawings, the present application also provides a signal control method for tumor electric field treatment, which is used for the electrode sheet 13 described above, and the method comprises:

[0140] Step 310: combine the control switch 54 and the bidirectional switch 55 electrically connected to the electrode sheet 13 to apply an alternating electric signal to each electrode unit 33 of the electrode sheet 13 and perform step 320;

[0141] Step 320: combine the control switch 54 and the bidirectional switch 55 electrically connected to the electrode sheet 13 to collect temperature detection signals of each electrode unit 33 of the electrode sheet 13 in a row and perform step 330;

[0142] Step 330: determine the combination control mode of the control switch 54 and the bidirectional switch 55 electrically connected to the electrode sheet 13 according to the collected temperature detection signals and perform step 340;

[0143] Step 340: control the working state of each electrode unit 33 of the electrode sheet 13 according to the determined combination control mode of the control switch 54 and the bidirectional switch 55.

[0144] The working state of each electrode unit 33 of the electrode sheet 13 in step 340 includes at least one of stopping applying the alternating electric signal and continuing to collect the temperature detection signal, and stopping collecting the temperature detection signal and continuing to apply the alternating electric signal. Continuing to apply the alternating electric signal includes continuing to apply the alternating electric signal in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal, or continuing to apply the alternating electric signal in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged, or continuing to apply the alternating electric signal in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal.

[0145] The working state of each electrode unit 33 of the electrode sheet 13 is determined by the temperature detection signal collected thereby. Each electrode unit 33 of the electrode sheet 13 is divided into different regions, and each electrode unit 33 in each region can be cyclically switched between applying the alternating electric signal and collecting the temperature detection signal through the combination control of the control switch 54 and the bidirectional switch 55.

[0146] The present application provides another electrode sheet temperature detection method for the tumor electric field treatment system 100. Please refer to FIG. 5, which shows the temperature detection method, including: Figure 15

[0147] Step 510: disconnect the input of the alternating electric signal of the electrode sheet 13, combine the control switch 54 and the bidirectional switch 55, and obtain the temperature detection signal of the temperature detection unit 35 of the electrode sheet 13 corresponding to each combination;

[0148] Step 520: sample and convert the temperature detection signal detected by each temperature detection unit 35 of the electrode sheet 13 to obtain a digital temperature signal;

[0149] ​Step 530: transmit the digital temperature signal to the electric field generator 30 of the tumor electric field treatment system 100, so that the electric field generator 30 determines the temperature at the corresponding electrode unit 33 according to the digital temperature signal.

[0150] In step 510, the combined control of the plurality of control switches 54 and the plurality of bidirectional switching switches 55 specifically includes:

[0151] Step 511: place all bidirectional switching switches 55 in the signal acquisition end 1 to turn on the electrical connection between the signal end 35-2 of each temperature detection unit 35 corresponding to each electrode unit 33 and the corresponding ADC unit 52;

[0152] Step 512: sequentially and separately close one of the plurality of control switches 54 in time to collect the temperature detection signals detected by each temperature detection unit 35 corresponding to each electrode unit 33 in the corresponding row group in turn.

[0153] Sequentially and separately closing one of the plurality of control switches 54 in step 512 can make the detection channel of the ADC unit 52 and each temperature detection unit 35 in the row group corresponding to the closed control switch 54 electrically connected.

[0154] Therefore, the temperature detection signals of each temperature detection unit 35 in each row group can be obtained in turn, and the temperature corresponding to each electrode unit 33 on the electrode sheet 13 can be obtained after processing by the adapter 20 or the electric field generator 30, so that the temperature detection of the patient's body surface is more comprehensive and accurate.

[0155] The tumor electric field treatment system 100 of the embodiment of the present application can also detect the temperature of a single electrode unit 33 as needed. The specific process of detecting the temperature of a certain electrode unit 33 of the electrode sheet 13 is as follows: disconnect the input of the alternating electric signal, place the bidirectional switching switch 55 corresponding to the column group in which the electrode unit 33 to be individually temperature detected in the signal acquisition end 1, and place the remaining bidirectional switching switches 55 in the signal input end 2; at the same time, turn on and ground the control switch 54 corresponding to the row group in which the electrode unit 33 to be individually temperature detected, and disconnect all the remaining control switches 54. Therefore, the temperature detection signal of the temperature detection unit 35 corresponding to the electrode unit 33 to be individually temperature detected can be sampled to obtain the temperature of the electrode unit 33. For example, the electrode unit 33 to be individually temperature detected is the electrode unit 33-1, at this time, the bidirectional switching switch 55-1 corresponding to the electrode unit 33-1 is placed in the signal acquisition end 1, and the remaining bidirectional switching switches (55-2 to 55-5) are all placed in the signal input end 2; at the same time, the control switch 18-1 corresponding to the electrode unit 33-1 is closed and grounded, and the remaining control switches (18-2 to 18-4) are all disconnected. Therefore, the temperature of the electrode unit 33-1 can be detected.

[0156] The embodiment of the present application also provides another method for applying an alternating electric signal for tumor electric field therapy, which is applied to the tumor electric field therapy system 100 and please refer to Figure 16 The method for applying an alternating electric signal comprises the following steps:

[0157] Step 610: determining the area (1-5) in the electrode sheet 13 where the electrode unit 33 needs to apply an alternating electric signal.

[0158] Step 611: combining the control of the multiple control switches 54 and the multiple bidirectional switches 55 which are electrically connected with the electrode sheet 13 to apply the alternating electric signal.

[0159] The combination control of the multiple control switches 54 and the multiple bidirectional switches 55 which are electrically connected with the electrode sheet 13 in step 611 is specifically as follows:

[0160] Step 612: disconnecting all the control switches 54 which are electrically connected with the electrode sheet 13.

[0161] Step 613: determining the column group where the electrode unit 33 needs to apply an alternating electric signal according to the area where the electrode unit 33 needs to apply an alternating electric signal.

[0162] Step 614: determining the bidirectional switch 55 which is electrically connected with the electrode unit 33 in the column group according to the determination of the column group where the electrode unit 33 needs to apply an alternating electric signal.

[0163] Step 615: controlling the bidirectional switch 55 which is electrically connected with the electrode unit 33 to make the electrode unit 33 electrically connected to the alternating power line 57 to apply an alternating electric signal; and controlling the remaining bidirectional switches 55 to make the electrical connection between the electrode unit 33 in the area which does not need to apply an alternating electric signal and the alternating power line 57 disconnected to stop applying an alternating electric signal.

[0164] In step 615, the process of “making the electrode unit which needs to apply an alternating electric signal electrically connected to the alternating power line 57 to apply an alternating electric signal and making the electrical connection between the electrode unit 33 in the area which does not need to apply an alternating electric signal and the alternating power line 57 disconnected to stop applying an alternating electric signal” is realized by placing the bidirectional switch 55 which is electrically connected with the electrode unit 33 in the column group corresponding to the area (1-5) in the electrode sheet 13 where the alternating electric signal needs to be applied at the signal input end 2, and placing all the bidirectional switches 55 which are electrically connected with the electrode unit 33 in the remaining column groups at the signal collection end 1.

[0165] The first controller 51 in the adapter 20 of the tumor electric field treatment system 100 or the electric field generator 30 is provided with a preset number threshold, a first preset temperature t1, a second preset temperature t2, and a preset temperature threshold t0, wherein the first preset temperature t1 is lower than the second preset temperature t2, and the second preset temperature t2 is lower than the preset temperature threshold t0.

[0166] The application also provides an alternating electric signal application method based on a temperature detection signal, which is used for the tumor electric field treatment system 100. Figure 17 to Figure 20 The application method comprises the following steps:

[0167] Step 710: starting the tumor electric field treatment system 100;

[0168] Step 711: combining control of the control switch 54 (also referred to as a grounding switch) and the bidirectional switch 55 connected to the electrode sheet 13 to apply an alternating electric signal to each electrode unit 33 of the electrode sheet 13;

[0169] Step 712: combining control of the control switch 54 and the bidirectional switch 55 connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13;

[0170] Step 713: determining whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, and when there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, executing step 714, and when there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, executing step 715;

[0171] Step 714: continuing to apply an alternating electric signal to each electrode unit 33 of the electrode sheet 13 in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal and returning to step 712;

[0172] Step 715: determining whether there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, and when there is no electrode unit 33 with a temperature exceeding the second preset temperature t2, executing step 716, and when there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, executing step 717;

[0173] Step 716: continuing to apply an alternating electric signal to each electrode unit 33 of the electrode sheet 13 in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged and returning to step 712;

[0174] Step 717: determining whether there is an electrode unit 33 with a temperature exceeding the preset temperature threshold t0, and when there is no electrode unit 33 with a temperature exceeding the preset temperature threshold t0, executing step 718, and when there is an electrode unit with a temperature exceeding the preset temperature threshold t0, executing step 719;

[0175] Step 718: continue to apply the alternating electric signal to all electrode units 33 of the electrode sheet 13 in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal and return to step 712;

[0176] Step 719: determine the number of over-temperature regions and execute step 720, wherein the over-temperature region is a region containing electrode units whose temperature exceeds the preset temperature threshold t0, and the non-over-temperature region is a region in which the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0177] Step 720: determine whether the number of over-temperature regions exceeds the preset number threshold, and execute step 721 when the number of over-temperature regions exceeds the preset number threshold, and execute step 724 when the number of over-temperature regions does not exceed the preset number threshold;

[0178] Step 721: stop applying the alternating electric signal to each electrode unit 33 of the electrode sheet 13 and execute step 722;

[0179] Step 722: combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and execute step 723;

[0180] Step 723: determine whether there is an electrode unit 33 whose temperature exceeds the first preset temperature t1, and return to step 711 when the electrode sheet 13 does not have an electrode unit 33 whose temperature exceeds the first preset temperature t1, and return to step 722 when the electrode sheet 13 has an electrode unit 33 whose temperature exceeds the first preset temperature t1;

[0181] Step 724: distinguish the over-temperature region and the non-over-temperature region according to whether there is an electrode unit 33 whose temperature exceeds the preset temperature threshold t0, and execute step 725 when the region is an over-temperature region, and execute step 726 when the region is a non-over-temperature region;

[0182] Step 725: stop applying the alternating electric signal to each electrode unit 33 of the over-temperature region and execute step 731;

[0183] Step 726: determine whether the temperature of each electrode unit 33 in the non-over-temperature region does not exceed the first preset temperature t1, and execute step 727 when the temperature of each electrode unit 33 in the non-over-temperature region does not exceed the first preset temperature t1, and execute step 728 when there is a temperature exceeding the first preset temperature t1 among the temperatures of the electrode units 33 in the non-over-temperature region;

[0184] Step 727: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal and execute step 731;

[0185] Step 728: judge whether the temperature of each electrode unit 33 in the non-over-temperature region exceeds the second preset temperature t2, and when the temperature of each electrode unit 33 in the non-over-temperature region does not exceed the second preset temperature t2, step 729 is executed, and when the temperature of each electrode unit 33 in the non-over-temperature region exceeds the second preset temperature t2, step 730 is executed;

[0186] Step 729: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged, and step 731 is executed;

[0187] Step 730: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal, and step 731 is executed;

[0188] Step 731: combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to reacquire the temperature of each electrode unit 33 of the electrode sheet 13, and select to execute step 732 or step 734, the temperature of each electrode unit 33 of the electrode sheet 13 includes the temperature of each electrode unit 33 in the over-temperature region and the temperature of each electrode unit 33 in the non-over-temperature region;

[0189] Step 732: judge whether the temperature of each electrode unit 33 in the over-temperature region exceeds the first preset temperature t1, and when the temperature of each electrode unit 33 in the over-temperature region does not exceed the first preset temperature t1, step 733 is executed, and when the temperature of each electrode unit 33 in the over-temperature region exceeds the first preset temperature t1, step 731 is returned;

[0190] Step 733: re-determine the region as the non-over-temperature region, and step 734 is executed;

[0191] Step 734: judge whether the temperature of each electrode unit 33 in the non-over-temperature region exceeds the first preset temperature t1, and when the temperature of each electrode unit 33 in the non-over-temperature region does not exceed the first preset temperature t1, step 735 is executed, and when the temperature of each electrode unit 33 in the non-over-temperature region exceeds the first preset temperature t1, step 736 is executed;

[0192] Step 735: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal, and return to step 712;

[0193] Step 736: judge whether the temperature of each electrode unit 33 in the acquired non-over temperature region exceeds the second preset temperature t2, when the temperature of each electrode unit 33 in the non-over temperature region does not exceed the second preset temperature t2, step 737 is executed, when there is a temperature exceeding the second preset temperature t2 in the temperature of each electrode unit 33 in the non-over temperature region, step 738 is executed;

[0194] Step 737: continue to apply the alternating electric signal to each electrode unit 33 in the non-over temperature region in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged, and return to step 712;

[0195] Step 738: judge whether the temperature of each electrode unit 33 in the acquired non-over temperature region exceeds the preset temperature threshold t0, when the temperature of each electrode unit 33 in the non-over temperature region does not exceed the preset temperature threshold t0, step 739 is executed, when there is a temperature exceeding the preset temperature threshold t0 in the temperature of each electrode unit 33 in the non-over temperature region, return to step 719;

[0196] Step 739: continue to apply the alternating electric signal to each electrode unit 33 in the non-over temperature region in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal, and return to step 712.

[0197] The combination control in step 711 is specifically:

[0198] all control switches 54 connected with the corresponding electrode sheet 13 are disconnected, and all bidirectional switching switches 55 connected with the corresponding electrode sheet 13 are switched to one end of the alternating electric signal at the same time; or

[0199] all control switches 54 connected with the corresponding electrode sheet 13 are disconnected, and all bidirectional switching switches 55 connected with the corresponding electrode sheet 13 are switched to one end of the alternating electric source line 57 at the same time; or

[0200] all control switches 54 connected with the corresponding electrode sheet 13 are disconnected, and all bidirectional switching switches 55 connected with the corresponding electrode sheet 13 are switched to their respective signal input ends 2 at the same time.

[0201] The process of acquiring the temperature of each electrode unit 33 of the electrode sheet 13 in step 712, step 722 and step 731 is specifically:

[0202] The control switch 55 connected with the electrode sheet 13 is switched from the end for applying alternating electric signal to the end for collecting temperature, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0203] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 for applying alternating electric signal to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0204] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 for applying alternating electric signal to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0205] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 for applying alternating electric signal to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0206] The first preset temperature in the step 713, the step 723, the step 726, the step 732 and the step 734 is 40-40.3℃, preferably 40.2℃. The second preset temperature in the step 715, the step 728 and the step 736 is 40.4-40.6℃, preferably 40.5℃. The preset temperature threshold in the step 717 and the step 738 is 41-41.5℃, preferably 41℃. The preset quantity threshold in the step 720 is preferably 2.

[0207] The process of continuously applying alternating electric signal in the step 714, the step 716, the step 718, the step 727, the step 729, the step 730, the step 735, the step 737 and the step 739 is specifically:

[0208] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the alternating electric signal transmission path connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied to the on state, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0209] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal collection end 1 of the bidirectional switch 55 to the signal input end 2, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0210] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal input end 2 of the bidirectional switch 55 to the alternating power line 57, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0211] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal input end 2 of the bidirectional switch 55 to the on state and the signal collection end 1 to the off state, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0212] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal input end 2 of the bidirectional switch 55 to the on state and the signal collection end 1 to the off state, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0213] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal input end 2 of the bidirectional switch 55 to the on state and the signal collection end 1 to the off state, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0214] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is opened, and at the same time, the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal needs to be continuously applied is controlled to switch the signal input end 2 of the bidirectional switch 55 to the on state and the signal collection end 1 to the off state, so as to continuously apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continuously applied; or

[0215] The process of stopping applying alternating electric signal to each electrode unit 33 of the electrode sheet 13 in step 721 is specifically:

[0216] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to disconnect each electrode unit 33 of the electrode sheet 13 from the alternating power line 57; or

[0217] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch all the signal input ends 2 of the bidirectional switch 55 for applying alternating electric signal to each electrode unit 33 of the electrode sheet 13 to the signal collection ends 1 of the bidirectional switch 55 for collecting temperature of each electrode unit 33 of the electrode sheet 13; or

[0218] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch all the signal input ends 2 of the bidirectional switch 55 for applying alternating electric signal to each electrode unit 33 of the electrode sheet 13 to the signal collection ends 1 of the bidirectional switch 55 for collecting temperature of each electrode unit 33 of the electrode sheet 13; or

[0219] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from being electrically connected with the alternating power line 57 to being electrically connected with the corresponding temperature detection unit 35 and the corresponding analog-digital converter 53; or

[0220] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from transmitting alternating electric signal to transmitting direct current signal or temperature detection signal to the corresponding temperature detection unit 35.

[0221] The process of stopping applying alternating electric signal to each electrode unit 33 of the over-temperature area in step 725 is specifically:

[0222] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to disconnect each electrode unit 33 of the over-temperature area from the alternating power line 57; or

[0223] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch all the signal input ends 2 of the bidirectional switch 55 for applying alternating electric signal to each electrode unit 33 of the over-temperature area to the signal collection ends 1 of the bidirectional switch 55 for collecting temperature of each electrode unit 33 of the over-temperature area; or

[0224] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch all the signal input ends 2 of the bidirectional switch 55 for applying alternating electric signal to each electrode unit 33 of the over-temperature area to the signal collection ends 1 of the bidirectional switch 55 for collecting temperature of each electrode unit 33 of the over-temperature area; or

[0225] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch each electrode unit 33 of the over-temperature area from being electrically connected with the alternating power line 57 to being electrically connected with the corresponding temperature detection unit 35 and the corresponding analog-digital converter 53; or

[0226] The bi-directional switch 55 connected with the electrode unit 33 of the over-temperature region is controlled to switch the electrode unit 33 of the over-temperature region from transmitting the alternating electric signal to transmitting the direct-current electric signal or the temperature detection signal to the corresponding temperature detection unit 35.

[0227] In the above control method, the tumor electric field treatment system 100 comprises at least two pairs of electrode sheets 13 to alternately apply alternating electric fields with different directions, and each electrode sheet 13 can be switched between applying the alternating electric signal and transmitting the temperature detection signal.

[0228] The first controller 51 in the adapter 20 of the tumor electric field treatment system 100 or the electric field generator 30 further comprises a third preset temperature t3, which is higher than the second preset temperature t2 but still lower than the preset temperature threshold t0. The third preset temperature t3 is closer to the preset temperature threshold t0 than the second preset temperature t2. The application further provides an alternating electric signal control method based on the temperature detection signal, which is used for the above tumor electric field treatment system, and the alternating electric signal control method comprises the following steps. Figure 18 As shown in the figure, the alternating electric signal control method comprises the following steps.

[0229] Step 810: starting the tumor electric field treatment system 100;

[0230] Step 811: controlling the control switch 54 (also referred to as the grounding switch) and the bi-directional switch 55 connected with the corresponding electrode sheet 13 to apply the alternating electric signal to the electrode unit 33 of the electrode sheet 13;

[0231] Step 812: controlling the control switch 54 and the bi-directional switch 55 connected with the electrode sheet 13 to obtain the temperature of the electrode unit 33 of the electrode sheet 13;

[0232] Step 813: judging whether there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, and when there is no electrode unit 33 with a temperature exceeding the first preset temperature t1, executing step 814, and when there is an electrode unit 33 with a temperature exceeding the first preset temperature t1, executing step 815;

[0233] Step 814: continuing to apply the alternating electric signal to the electrode unit 33 of the electrode sheet 13 in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal and returning to step 812;

[0234] Step 815: judging whether there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, and when there is no electrode unit 33 with a temperature exceeding the second preset temperature t2, executing step 816, and when there is an electrode unit 33 with a temperature exceeding the second preset temperature t2, executing step 817;

[0235] Step 816: continue to apply the alternating electric signal to each electrode unit 33 of the electrode sheet 13 in a manner that keeps the voltage or current amplitude of the currently applied alternating electric signal unchanged and return to step 812;

[0236] Step 817: determine whether there is an electrode unit 33 whose temperature exceeds the third preset temperature t3, and when there is no electrode unit 33 whose temperature exceeds the third preset temperature t3, execute step 818; and when there is an electrode unit whose temperature exceeds the third preset temperature t3, execute step 819;

[0237] Step 818: continue to apply the alternating electric signal to all electrode units 33 of the electrode sheet 13 in a manner that reduces the voltage or current amplitude of the currently applied alternating electric signal and return to step 812;

[0238] Step 819: determine whether there is an electrode unit 33 whose temperature exceeds the preset temperature threshold t0, and when there is no electrode unit 33 whose temperature exceeds the preset temperature threshold t0, execute step 820; and when there is an electrode unit whose temperature exceeds the preset temperature threshold t0, execute step 821;

[0239] Step 820: continue to apply the alternating electric signal to all electrode units 33 of the electrode sheet 13 in a manner that reduces the voltage or current amplitude of the currently applied alternating electric signal and return to step 812;

[0240] Step 821: determine the number of over-temperature regions and execute step 822, wherein an over-temperature region is a region containing an electrode unit whose temperature exceeds the preset temperature threshold t0, and an under-temperature region is a region in which the temperature of all electrode units does not exceed the preset temperature threshold t0;

[0241] Step 822: determine whether the number of over-temperature regions exceeds a preset number threshold, and when the number of over-temperature regions exceeds the preset number threshold, execute step 823; and when the number of over-temperature regions does not exceed the preset number threshold, execute step 826;

[0242] Step 823: stop applying the alternating electric signal to each electrode unit 33 of the electrode sheet 13 and execute step 824;

[0243] Step 824: combine the control switch 54 and the bidirectional switching switch 55 electrically connected to the electrode sheet 13 to obtain the temperature of each electrode unit 33 of the electrode sheet 13 and execute step 825;

[0244] Step 825: determine whether there is an electrode unit 33 whose temperature exceeds the first preset temperature t1, and when there is no electrode unit 33 whose temperature exceeds the first preset temperature t1 of the electrode sheet 13, return to step 811; and when there is an electrode unit 33 whose temperature exceeds the first preset temperature t1 of the electrode sheet 13, return to step 824;

[0245] Step 826: distinguishing the over-temperature region from the non-over-temperature region according to whether the electrode unit 33 contains a temperature exceeding a preset temperature threshold t0, and executing step 827 when the region is an over-temperature region, and executing step 828 when the region is a non-over-temperature region;

[0246] Step 827: stopping applying the alternating electric signal to each electrode unit 33 in the over-temperature region and executing step 835;

[0247] Step 828: judging whether the temperature of each electrode unit 33 in the non-over-temperature region is all below a first preset temperature t1, and executing step 829 when the temperature of each electrode unit 33 in the non-over-temperature region is all below the first preset temperature t1, and executing step 830 when there is a temperature exceeding the first preset temperature t1 among the temperature of each electrode unit 33 in the non-over-temperature region;

[0248] Step 829: continuing to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal and executing step 835;

[0249] Step 830: judging whether the temperature of each electrode unit 33 in the non-over-temperature region is all below a second preset temperature t2, and executing step 831 when the temperature of each electrode unit 33 in the non-over-temperature region is all below the second preset temperature t2, and executing step 832 when there is a temperature exceeding the second preset temperature t2 among the temperature of each electrode unit 33 in the non-over-temperature region;

[0250] Step 831: continuing to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged and executing step 835;

[0251] Step 832: judging whether there is an electrode unit 33 with a temperature exceeding a third preset temperature t3 among the temperature of each electrode unit 33 in the non-over-temperature region, and executing step 833 when the temperature of each electrode unit 33 in the non-over-temperature region is all below the third preset temperature t3, and executing step 834 when there is an electrode unit 33 with a temperature exceeding the third preset temperature t3 among the temperature of each electrode unit 33 in the non-over-temperature region;

[0252] Step 833: continuing to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of decreasing the voltage or current amplitude of the currently applied alternating electric signal and executing step 835;

[0253] Step 834: continuing to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region of the electrode sheet 13 in a manner of further decreasing the voltage or current amplitude of the currently applied alternating electric signal and executing step 835;

[0254] Step 835: combine the control switch 54 and the bidirectional switch 55 electrically connected to the electrode sheet 13 to reacquire the temperature of each electrode unit 33 of the electrode sheet 13, including the temperature of each electrode unit 33 in the over-temperature region and the temperature of each electrode unit 33 in the non-over-temperature region, and select to execute step 836 or step 838;

[0255] Step 836: determine whether the temperature of each electrode unit 33 in the over-temperature region is less than the first preset temperature t1, execute step 837 when the temperature of each electrode unit 33 in the over-temperature region is less than the first preset temperature t1, and return to step 835 when there is a temperature of each electrode unit 33 in the over-temperature region that exceeds the first preset temperature t1;

[0256] Step 837: re-determine the region as a non-over-temperature region and execute step 838;

[0257] Step 838: determine whether the temperature of each electrode unit 33 in the non-over-temperature region is less than the first preset temperature t1, execute step 839 when the temperature of each electrode unit 33 in the non-over-temperature region is less than the first preset temperature t1, and execute step 840 when there is a temperature of each electrode unit 33 in the non-over-temperature region that exceeds the first preset temperature t1;

[0258] Step 839: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal, and return to step 812;

[0259] Step 840: determine whether the temperature of each electrode unit 33 in the non-over-temperature region is less than the second preset temperature t2, execute step 841 when the temperature of each electrode unit 33 in the non-over-temperature region is less than the second preset temperature t2, and execute step 842 when there is a temperature of each electrode unit 33 in the non-over-temperature region that exceeds the second preset temperature t2;

[0260] Step 841: continue to apply the alternating electric signal to each electrode unit 33 in the non-over-temperature region in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged, and return to step 812;

[0261] Step 842: determine whether the temperature of each electrode unit 33 in the non-over-temperature region is less than the third preset temperature t3, execute step 843 when the temperature of each electrode unit 33 in the non-over-temperature region is less than the third preset temperature t3, and execute step 844 when there is a temperature of each electrode unit 33 in the non-over-temperature region that exceeds the third preset temperature t3;

[0262] Step 843: continue to apply the alternating electric signal to each electrode unit 33 of the non-over-temperature area in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal and return to step 812;

[0263] Step 844: determine whether the temperature of each electrode unit 33 in the non-over-temperature area obtained is all below the preset temperature threshold t0, and execute step 845 when the temperature of each electrode unit 33 in the non-over-temperature area is all below the preset temperature threshold t0, and return to step 821 when there is a temperature exceeding the preset temperature threshold t0 among the temperature of each electrode unit 33 in the non-over-temperature area;

[0264] Step 845: continue to apply the alternating electric signal to each electrode unit 33 of the non-over-temperature area in a manner of further reducing the voltage or current amplitude of the currently applied alternating electric signal and return to step 812.

[0265] The combination control in step 811 is specifically:

[0266] all control switches 54 connected to the corresponding electrode sheet 13 are opened, and all bidirectional switching switches 55 connected to the corresponding electrode sheet 13 are switched to the end of making each electrode unit 33 apply the alternating electric signal; or

[0267] all control switches 54 connected to the corresponding electrode sheet 13 are opened, and all bidirectional switching switches 55 connected to the corresponding electrode sheet 13 are switched to the end of making each electrode unit 33 connected to the alternating power line 57; or

[0268] all control switches 54 connected to the corresponding electrode sheet 13 are opened, and all bidirectional switching switches 55 connected to the corresponding electrode sheet 13 are switched to their respective signal input ends 2.

[0269] The process of obtaining the temperature of each electrode unit 33 of the electrode sheet 13 in step 812, step 824 and step 835 is specifically:

[0270] all bidirectional switching switches 55 connected to the electrode sheet 13 are switched from the end of making each electrode unit 33 apply the alternating electric signal to the end of making each electrode unit 33 collect temperature, and the control switches 54 connected to the temperature detection units 35 corresponding to the electrode units 33 of the electrode sheet 13 are sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0271] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0272] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0273] The control switch 55 connected with the electrode sheet 13 is switched from the signal input end 2 to the signal collection end 1, and the control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 of the electrode sheet 13 is sequentially closed in time to obtain the temperature of each electrode unit 33 of the electrode sheet 13; or

[0274] The first preset temperature in steps 813, 825, 828, 836, and 838 is 40-40.3℃, preferably 40.2℃. The second preset temperature in steps 815, 830, and 840 is 40.4-40.6℃, preferably 40.5℃. The third preset temperature in steps 817, 832, and 842 is 40.7-40.9℃, preferably 40.8℃. The preset temperature threshold in steps 819 and 844 is 41-41.5℃, preferably 41℃. The preset number threshold in step 822 is preferably 2.

[0275] The process of continuing to apply the alternating electric signal in steps 814, 816, 818, 820, 829, 831, 833, 834, 839, 841, 843, and 845 is specifically:

[0276] The control switch 54 connected with the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal needs to be continued to be applied is opened, and the control switch 55 connected with the electrode unit 33 to which the alternating electric signal needs to be continued to be applied is controlled to be turned on to continue to apply the alternating electric signal to the electrode unit 33 to which the alternating electric signal needs to be continued to be applied; or

[0277] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal is to be continuously applied is opened, and at the same time, the signal input end 2 of the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal is to be continuously applied is connected to the signal collection end 1 of the bidirectional switch 55, so that the alternating electric signal is continuously applied to the electrode unit 33 to which the alternating electric signal is to be continuously applied; or

[0278] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal is to be continuously applied is opened, and at the same time, the signal input end 2 of the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal is to be continuously applied is connected to the signal collection end 1 of the bidirectional switch 55, so that the alternating electric signal is continuously applied to the electrode unit 33 to which the alternating electric signal is to be continuously applied; or

[0279] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal is to be continuously applied is opened, and at the same time, the signal input end 2 of the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal is to be continuously applied is connected to the signal collection end 1 of the bidirectional switch 55, so that the alternating electric signal is continuously applied to the electrode unit 33 to which the alternating electric signal is to be continuously applied; or

[0280] The control switch 54 connected to the temperature detection unit 35 corresponding to the electrode unit 33 to which the alternating electric signal is to be continuously applied is opened, and at the same time, the signal input end 2 of the bidirectional switch 55 connected to the electrode unit 33 to which the alternating electric signal is to be continuously applied is connected to the signal collection end 1 of the bidirectional switch 55, so that the alternating electric signal is continuously applied to the electrode unit 33 to which the alternating electric signal is to be continuously applied; or

[0281] The way of increasing the voltage or current amplitude of the alternating electric signal to be continuously applied in the steps 814, 829, and 839 is specifically to continue to apply the alternating electric signal after increasing the voltage amplitude of the alternating electric signal to be continuously applied by 0.03 V per second.

[0282] The way of decreasing the voltage or current amplitude of the alternating electric signal to be continuously applied in the steps 818, 820, 833, 834, 843, and 845 is specifically to continue to apply the alternating electric signal with a voltage amplitude of 5 V less than the voltage amplitude of the alternating electric signal to be continuously applied for 3 minutes.

[0283] The process of stopping the application of the alternating electric signal to each electrode unit 33 of the electrode sheet 13 in the step 823 is specifically:

[0284] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to disconnect the electrical connection between each electrode unit 33 of the electrode sheet 13 and the alternating power supply line 57; or

[0285] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch all the signal input ends 2 of the bidirectional switch 55, which apply alternating electric signals to each electrode unit 33, to the signal collection ends 1 of the bidirectional switch 55; or

[0286] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from transmitting alternating electric signals to transmitting direct current signals or temperature detection signals to the corresponding temperature detection unit 35.

[0287] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from being electrically connected with the alternating power supply line 57 to being electrically connected with the corresponding temperature detection unit 35 and the corresponding analog-digital converter 53.

[0288] controlling the bidirectional switch 55 electrically connected with the electrode sheet 13 to switch each electrode unit 33 of the electrode sheet 13 from transmitting alternating electric signals to transmitting direct current signals or temperature detection signals to the corresponding temperature detection unit 35.

[0289] the process of stopping applying alternating electric signals to each electrode unit 33 of the over-temperature area in step 827 is specifically:

[0290] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to disconnect the electrical connection between each electrode unit 33 of the over-temperature area and the alternating power supply line 57; or

[0291] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch all the signal input ends 2 of the bidirectional switch 55, which apply alternating electric signals to each electrode unit 33 of the over-temperature area, to the signal collection ends 1 of the bidirectional switch 55; or

[0292] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch all the signal input ends 2 of the bidirectional switch 55, which apply alternating electric signals to each electrode unit 33 of the over-temperature area, to the signal collection ends 1 of the bidirectional switch 55; or

[0293] controlling the bidirectional switch 55 electrically connected with each electrode unit 33 of the over-temperature area to switch each electrode unit 33 of the over-temperature area from being electrically connected with the alternating power supply line 57 to being electrically connected with the corresponding temperature detection unit 35 and the corresponding analog-digital converter 53.

[0294] The bidirectional switch 55 connected with each electrode unit 33 of the over-temperature area is controlled to switch the transmission of the alternating electric signal of each electrode unit 33 of the over-temperature area to the transmission of the direct current signal or the temperature detection signal of the corresponding temperature detection unit 35.

[0295] When the tumor electric field treatment system 100 is in the standby state before starting work, no alternating electric signal is applied to the electrode unit 33, the first controller 51 of the adapter 20 or the second controller 37 of the electric field generator 30 controls the bidirectional switch 55 (55-1 to 55-5) to switch to the signal acquisition end 1, and controls the switches 54 (54-1 to 54-4) to be turned on in turn, respectively, so that the ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to each row of electrode units 33 (33-1 to 33-20) in turn.

[0296] When the control switch 54-1 is turned on, the control switches (54-2, 54-3, 54-4) are all turned off, and the bidirectional switches (55-1 to 55-5) are all set to the signal acquisition end 1, the ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to the electrode units (33-1 to 33-5);

[0297] When the control switch 54-2 is turned on, the control switches (54-1, 54-3, 54-4) are all turned off, and the bidirectional switches (55-1 to 55-5) are all set to the signal acquisition end 1, the ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to the electrode units (33-6 to 33-10);

[0298] When the control switch 54-3 is turned on, the control switches (54-1, 54-2, 54-4) are all turned off, and the bidirectional switches (55-1 to 55-5) are all set to the signal acquisition end 1, the ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to the electrode units (33-11 to 33-15);

[0299] When the control switch 54-4 is turned on, the control switches (54-1, 54-2, 54-3) are all turned off, and the bidirectional switches (55-1 to 55-5) are all set to the signal acquisition end 1, the ADC unit 52 receives the temperature detection signal of the temperature detection unit 35 corresponding to the electrode units (33-16 to 33-20).

[0300] The first controller 51 receives the temperature detection signal of the temperature detection unit 35 corresponding to each electrode unit 33 (33-1 to 33-20) through the ADC unit 52, and transmits it to the alternating current signal generator 39 of the electric field generator 30 through the first communication unit 56 and the second communication unit 38, and then controls or adjusts the alternating electric signal applied to each electrode unit 33 through the second controller 37.

[0301] Although the various operations are depicted as occurring in a particular order, this is not intended to be a requirement but is merely an example. The operations can be performed in any order, and not all operations can be performed (e.g., if some of the operations are not needed to achieve the desired result).

[0302] Embodiment 2:

[0303] The main idea of the tumor electric field treatment system 100 described above is that each of the adapter 20 and the electric field generator 30 is provided with one alternating power line 57, and the alternating electric signals of all the electrode units 33 on one electrode sheet 13 change synchronously, such as voltage or current rising or falling together, and different alternating electric signals, such as different voltages or currents, cannot be applied to different column groups of electrode units 33 at the same time. Figure 18 Another tumor electric field treatment system 100' is described below, which has the same main idea as the tumor electric field treatment system 100 described above, and the difference is that the adapter 20' and the electric field generator 30' of the tumor electric field treatment system 100' are each provided with one corresponding alternating power line 57' corresponding to each column group of electrode units 33' on the electrode sheet 13', so that different alternating electric signals, such as different voltages or currents, can be applied to different column groups of electrode units 33' at the same time.

[0304] Figure 19 The circuit connection schematic diagram of one electrode sheet 13' of another tumor electric field treatment system 100' of the present application and the adapter 20' and the electric field generator 30' is shown in the figure. The tumor electric field treatment system 100' comprises at least one pair of electrode sheets 13', an adapter 20' connected to the electrode sheet 13', and an electric field generator 30' connected to the adapter 20'.

[0305] The specific structure of the electrode sheet 13' is the same as that of the electrode sheet 13 described above, and will not be repeated here.

[0306] The specific structure of the adapter 20' is similar to that of the adapter 20 described above, and the difference is that, referring to Figure 18 and Figure 20 The adapter 20' is provided with five alternating power lines 57' corresponding to one electrode sheet 13', and the five alternating power lines 57' are one-to-one corresponding to the five column groups of electrode units 33' of one electrode sheet 13'. A corresponding bidirectional switch 55' and a grounding switch 54' are provided for each electrode sheet 13', and the signal input end 2 of the bidirectional switch 55' is electrically connected to one separate alternating power line 57', so that the tumor electric field treatment system 100' can apply different alternating electric signals, such as different voltages or currents, to different column groups of electrode units 33' in each electrode sheet 13' at the same time as needed.

[0307] The specific structure of the electric field generator 30' is similar to the electric field generator 30 described above, with the difference that, referring to Figure 18 and Figure 19 , the AC signal generator 39' and the alternating power lines 57' connected with the adapter 20' are provided with a power switch 40' for each alternating power line 57' to individually control the on-off of the alternating electric signal of each column group of electrode units 33' of each electrode sheet 13'.

[0308] Specifically, referring to Figure 18 and Figure 18 , the adapter 20' comprises a first controller 51', a plurality of groups of ADC units 52' connected with the first controller 51', a plurality of groups of voltage dividing resistors 53' and a plurality of groups of control switches 54' corresponding to the plurality of groups of ADC units 52', a plurality of groups of bidirectional switches 55' connected with the plurality of groups of ADC units 52' one by one, a first communication unit 56', a plurality of alternating power lines 57' connected with each group of bidirectional switches 55' one by one, and a first power module 58' connected with the first communication unit 56', the first controller 51' and the plurality of groups of ADC units 52' at the same time, and the first power module 58' provides direct current power VCC for each electronic component of the adapter 20'. The adapter 20' further comprises a plurality of circuit lines (not numbered), and the plurality of circuit lines (not numbered) are respectively and electrically connected with the plurality of ground lines 18' and the plurality of dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode sheet 13' through the first cable 15' of the corresponding electrode sheet 13'. The plurality of circuit lines (not numbered) comprise a plurality of different alternating power lines 57' respectively transmitting alternating electric signals to the corresponding electrode sheet 13' and electrically connected with the plurality of dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode sheet 13', a plurality of circuit lines (not numbered) respectively and electrically connected with the plurality of dual-purpose signal lines 19' in the substrate 31' of the corresponding electrode sheet 13' and used for supplying power to each temperature detection unit 35' of the electrode sheet 13' or transmitting the temperature detection signal of the electrode sheet 13', and a plurality of circuit lines (not numbered) respectively and electrically connected with the plurality of ground lines 18' in the substrate 31' of the corresponding electrode sheet 13'. The number L of circuit lines electrically connected with one electrode sheet 13' of the adapter 20' is equal to the sum of the number of rows and the number of columns of the electrode units 33' of the electrode sheet 13'; the number H of circuits electrically connected with X electrode sheets 13' of the adapter 20' is equal to X times of the number of circuit lines electrically connected with a single electrode sheet 13', that is, H = XL = X × (M + N). The number of groups of control switches 54' and the number of groups of bidirectional switches 55' are both related to the number of electrode sheets 13'. The number of groups of control switches 54' is the same as the number of groups of bidirectional switches 55' and is not less than the number of electrode sheets 13'. Optionally, the number of groups of control switches 54' and the number of groups of bidirectional switches 55' are both the same as the number of electrode sheets 13'.

[0309] For example, each group of control switches 54' is provided with a plurality of control switches 54' which are respectively connected into the adapter 20' and are respectively electrically connected to the circuit lines (not labeled) corresponding to the plurality of ground lines 18' of the corresponding one electrode sheet 13' one by one, and are configured to control the on or off of the plurality of ground lines 18'. The circuit lines (not labeled) of the plurality of ground lines 18' respectively one by one electrically connecting the electrode sheet 13' are grounded at one end close to the control switch 54'. The number of control switches 54' in each group of control switches 54' is related to the number of ground lines 18' of the corresponding base plate 31' of the electrode sheet 13', and in the present embodiment, the two are equal. As shown in the figure, in the present embodiment, the plurality of control switches 54' are respectively a first control switch 54-1', a second control switch 54-2', a third control switch 54-3', and a fourth control switch 54-4'. The plurality of control switches 54' in the same group respectively control the closing or opening of the corresponding ground line 18' of the same electrode sheet 13' one by one. The first control switch 54-1' is used to control the closing or opening of the first ground line 18-1' of the corresponding electrode sheet 13', and in turn can cooperate with the corresponding group of bidirectional switching switches 55' to control the power-on and power-off of each temperature detection unit 35' corresponding to the five electrode units 33-1' to 33-5' in the first row group 33 of the electrode sheet 13'; the second control switch 54-2' is used to control the closing or opening of the second ground line 18-2' of the electrode sheet 13', and in turn can cooperate with the corresponding group of bidirectional switching switches 55' to control the power-on and power-off of the temperature detection units 35' corresponding to the five electrode units 33-6' to 33-10' in the second row group 33' of the electrode sheet 13'; the third control switch 54-3' is used to control the closing or opening of the third ground line 18-3' of the electrode sheet 13', and in turn can cooperate with the corresponding group of bidirectional switching switches 55' to control the power-on and power-off of each temperature detection unit 35' corresponding to the five electrode units 33-11' to 33-15' in the third row group 33' of the electrode sheet 13'; the fourth control switch 54-4' is used to control the closing or opening of the fourth ground line 18-4' of the electrode sheet 13', and in turn can cooperate with the corresponding group of bidirectional switching switches 55' to control the power-on and power-off of each temperature detection unit 35' corresponding to the five electrode units 33-16' to 33-20' in the fourth row group 33' of the electrode sheet 13'. The above-mentioned control switches 54' can be mechanical switches, such as relays. The control switches 54' can also be electronic switches, and each control switch 54' can be operated by an additional first controller 51'. Figure 18

[0310] ​In the embodiment, each of the plurality of groups of control switches 54’ is an electronic switch. The first controller 51’ is in communication connection with the plurality of groups of control switches 54’, and is configured to sequentially and cyclically control the on-off state of each of the plurality of control switches 54’ in each group of control switches 54’, and in turn sequentially and individually turn on each of the plurality of ground lines 18’ of the corresponding electrode sheet 13’ and cooperate with the switching of the corresponding bidirectional switch 55’ to collect the temperature of the patient’s body surface detected by all the temperature detection units 35’ on the electrode sheet 13’. The number of control switches 54’ in each group of control switches 54’ is not less than the number of ground lines 18’ of the corresponding electrode sheet 13’ substrate 31’. In the embodiment, the number of control switches 54’ in each group of control switches 54’ is the same as the number of ground lines 18’ of the corresponding electrode sheet 13’.

[0311] Each group of bidirectional switches 55’ is provided with a plurality of bidirectional switches 55’, and each group of bidirectional switches 55’ is respectively connected to the circuit line (not numbered) corresponding to the plurality of dual-purpose signal lines 19’ of the corresponding electrode sheet 13’ in the adapter 20’ and is electrically connected to the circuit line (not numbered) corresponding to the plurality of dual-purpose signal lines 19’ of the corresponding electrode sheet 13’. The number of bidirectional switches 55’ in each group of bidirectional switches 55’ is related to the number of dual-purpose signal lines 19’ of the corresponding electrode sheet 13’ substrate 31’, and is greater than or equal to the number of dual-purpose signal lines 19’ of the corresponding electrode sheet 13’ substrate 31’, and in the embodiment, the number of bidirectional switches 55’ in each group of bidirectional switches 55’ is equal to the number of dual-purpose signal lines 19’ of the corresponding electrode sheet 13’ substrate 31’. Each bidirectional switch 55’ has two ends marked as 1 and 2. The signal collection end 1 of each bidirectional switch 55’ in the same group is electrically connected to the corresponding detection channel of the plurality of detection channels of the corresponding group of ADC units 52’ through a temperature sampling point (not numbered). The signal input end 2 of each bidirectional switch 55’ in the same group is electrically connected to a different alternating power line 57’, and is configured to control the connection of the plurality of dual-purpose signal lines 19’ to the different alternating power lines 57’ to transmit alternating electrical signals or to the corresponding detection channel of the corresponding group of ADC units 52’ to receive the temperature detection signal output by the temperature detection unit 35’.

[0312] As Figure 18As shown, taking the example of the electrical connection between one electrode sheet 13' and the adapter 20', in the present embodiment with 20 electrode units 33', the plurality of bidirectional switches 55' are respectively a first bidirectional switch 55-1', a second bidirectional switch 55-2', a third bidirectional switch 55-3', a fourth bidirectional switch 55-4', and a fifth bidirectional switch 55-5'. The bidirectional switches 55' in the same group respectively control the switching of a corresponding one of the multiplexed signal lines 19' of the same electrode sheet 13' between the transmission of the alternating electrical signal and the transmission of the temperature detection signal. Specifically, the first bidirectional switch 55-1' is configured to control the switching of the first multiplexed signal line 19-1' of the corresponding electrode sheet 13' between the transmission of the alternating electrical signal output by the alternating power supply line 57-1' and the transmission of the temperature detection signal, and further control the switching between the conduction of each electrode unit 33' in the first column group of electrode units 33-1', 33-6', 33-11', 33-16' of the electrode sheet 13' and the conduction of the signal terminal 35-2' of each temperature detection unit 35' corresponding to the electrode units 33-1', 33-6', 33-11', 33-16' in the first column group, and cooperate with the corresponding control switch 54-1', 54-2', 54-3', 54-4', so as to enable the first column of electrode units 33-1', 33-6', 33-11', 33-16' to transmit a separate alternating electrical signal to the patient or output the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode units 33' to the corresponding ADC unit 52'; the second bidirectional switch 55-2' is configured to control the switching of the second multiplexed signal line 19-2' of the corresponding electrode sheet 13' between the transmission of the alternating electrical signal output by the alternating power supply line 57-2' and the transmission of the temperature detection signal, and further control the switching between the conduction of each electrode unit 33' in the second column group of electrode units 33-2', 33-7', 33-12', 33-17' of the electrode sheet 13' and the conduction of the signal terminal 35-2' of each temperature detection unit 35' corresponding to the electrode units 33-2', 33-7', 33-12', 33-17' in the second column group, and cooperate with the corresponding control switch 54-1', 54-2', 54-3', 54-4', so as to enable the second column of electrode units 33-2', 33-7', 33-12', 33-17' to transmit a separate alternating electrical signal to the patient or output the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode units 33' to the corresponding ADC unit 52'.The third bidirectional switch 55-3' is used for controlling the third dual-purpose signal line 19-3' of the corresponding electrode sheet 13' to switch between transmitting the alternating electric signal output by the alternating power supply line 57-3' and transmitting the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the third column group of electrode units 33-3', 33-8', 33-13', 33-18' of the electrode sheet 13' and the conduction of the signal end 35-2' of each temperature detection unit 35' corresponding to the third column group of electrode units 33-3', 33-8', 33-13', 33-18', and cooperating with the corresponding control switch 54-1', 54-2', 54-3', 54-4', so that the third column of electrode units 33-3', 33-8', 33-13', 33-18' transmits a single alternating electric signal to the patient or outputs the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode unit 33' to the corresponding ADC unit 52'; the fourth bidirectional switch 55-4' is used for controlling the fourth dual-purpose signal line 19-4' of the corresponding electrode sheet 13' to switch between transmitting the alternating electric signal output by the alternating power supply line 57-4' and transmitting the temperature detection signal, thereby controlling the conduction of each electrode unit 33' in the fourth column group of electrode units 33-4', 33-9', 33-14', 33-19' of the electrode sheet 13' and the conduction of the signal end 35-2' of each temperature detection unit 35' corresponding to the fourth column group of electrode units 33-4', 33-9', 33-14', 33-19', and cooperating with the corresponding control switch 54-1', 54-2', 54-3', 54-4', so that the fourth column of electrode units 33-4', 33-9', 33-14', 33-19' transmits a single alternating electric signal to the patient or outputs the temperature detection signal collected by the temperature detection unit 35' corresponding to the electrode unit 33' to the corresponding ADC unit 52'.The fifth bidirectional switch 55-5' is used to control the switching of the fifth dual-purpose signal line 19-5' of the corresponding electrode sheet 13' between transmitting the alternating electric signal output by the alternating power supply line 57-5' and transmitting the temperature detection signal, thereby controlling the switching between the conduction of each electrode unit 33' of the electrode units 33-5', 33-10', 33-15', 33-20' in the fifth column group of the electrode sheet 13' and the conduction of the signal end 35-2' of the corresponding temperature detection unit 35' of the electrode units 33-5', 33-10', 33-15', 33-20' in the fifth column group, and cooperating with the corresponding control switch 54-1', 54-2', 54-3', 54-4', so that the fifth column electrode units 33-5', 33-10', 33-15', 33-20' transmit individual alternating electric signals to the patient or output the temperature detection signals collected by the corresponding temperature detection units 35' of the electrode units 33' to the corresponding ADC unit 52'. When the signal input end 2 of each group of bidirectional switches 55' is turned on and the signal collection end 1 is turned off, the alternating electric signals can be transmitted to each electrode unit 33' in each column group of the corresponding electrode sheet 13' through different alternating power supply lines 57'. When the signal collection end 1 of each group of bidirectional switches 55' is turned on and the signal input end 2 is turned off, it can be cooperated with each control switch 54' in the corresponding group of control switches 54' to transmit the temperature detection signals collected by the corresponding temperature detection units 35' of each electrode unit 33' on the electrode sheet 13' in time. The bidirectional switch 55' described above can be a mechanical switch, such as a relay. The bidirectional switch 55' can also be an electronic switch, and each bidirectional switch 55' can be switched by an additional first controller 51'.

[0313] In the present embodiment, each group of bidirectional switches 55' is an electronic switch. The first controller 51' is in communication connection with each group of bidirectional switches 55' for controlling the switching of each group of bidirectional switches 55' between the signal collection end 1 and the signal input end 2, and cooperating with the closing or opening of the corresponding control switch 54' to continuously monitor the temperature of the patient's body surface detected by all temperature detection units 35' on the electrode sheet 13' or transmit alternating electric signals to the patient.

[0314] In this embodiment, each ADC unit 52' is electrically connected one-to-one to the signal acquisition terminals 1 of multiple bidirectional switching switches 55' in the corresponding group via multiple circuit lines (unlabeled) within the adapter 20', and is configured to receive temperature detection signals transmitted from the multi-purpose signal lines 19' of the corresponding electrode 13', and convert the temperature detection signals from analog signals to digital signals. Each ADC unit 52' includes multiple detection channels A, B, C, D, and E, and each detection channel A, B, C, D, and E is used to connect to a corresponding dual-purpose signal line 19' in the multi-purpose signal lines 19' via the corresponding bidirectional switching switch 55'. Figure 18 As shown, each ADC unit 52' contains five detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1' via the signal acquisition terminal 1 of the first bidirectional switch 55-1'; the second detection channel B is connected to the second dual-purpose signal line 19-2' via the signal acquisition terminal 1 of the second bidirectional switch 55-2'; the third detection channel C is connected to the third dual-purpose signal line 19-3' via the signal acquisition terminal 1 of the third bidirectional switch 55-3'; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4' via the signal acquisition terminal 1 of the fourth bidirectional switch 55-4'; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5' via the signal acquisition terminal 1 of the fifth bidirectional switch 55-5'. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal acquired by the temperature detection unit 35' corresponding to the electrode unit 33' connected to the corresponding dual-purpose signal line 19'. In addition, each detection channel A, B, C, D, and E is connected to a first power supply module 58' via a corresponding voltage divider resistor 53' within the adapter 20'. The first power supply module 58' provides DC power to the detection channel A, B, C, D, and E.

[0315] In the present embodiment, the first communication unit 56' is configured to acquire the digital signals output by the plurality of groups of ADC units 52' and send the digital signals to the electric field generator 30'. The electric field generator 30' is also configured to control the voltage of the alternating electric signal provided to the plurality of electrode units 33' of the electrode sheet 13' according to the received digital signals. For example, when any of the plurality of received digital signals exceeds a preset threshold value, it indicates that the temperature detected by the temperature detection unit 35' corresponding to at least one electrode unit 33' of the electrode sheet 13' exceeds a preset threshold temperature (e.g. 41°C, 42°C, etc.), at which time the voltage of the alternating electric signal output by the electric field generator 30' can be appropriately reduced or stopped to avoid the electrode units 33' of the electrode sheet 13' from being overheated when the alternating electric signal is applied, which can cause a cold burn to the skin of the patient. The above-mentioned preset threshold temperature and preset threshold value can be determined according to the safety threshold of the human body. The first communication unit 56' is controlled by the first controller 51' and serially transmits the digital signals converted by the plurality of groups of ADC units 52'. In the present embodiment, the preset threshold temperature can be a value within 36°C-45°C.

[0316] Reference Figure 20In the embodiment, the first power module 58' is electrically connected with the second power module 32' of the electric field generator 30' and configured to supply power to the first controller 51', the groups of ADC units 52' and the first communication unit 56' of the adapter 20'. A first connector 60' is arranged between each electrode sheet 13' and the adapter 20' and adapted to connect the corresponding electrode sheet 13' to the adapter 20'. A second connector 70' is arranged between the adapter 20' and the electric field generator 30' and adapted to connect the electric field generator 30' to the adapter 20'. The adapter 20' further comprises a second cable 25' connected with the second connector 70'. The second connector 70' comprises a second plug 71' arranged at the end of the second cable 25' away from the first controller 51' and a second socket 72' arranged on the electric field generator 30'. The second plug 71' and the second socket 72' are press spring connectors, i.e. the second connector 70' connects the adapter 20' to the electric field generator 30' in the form of a connector. Each first connector 60' such as X1, Y1, X2 and Y2 is connected with the second connector 70' through a corresponding 5-way AC power line 57', and the first connector 60' such as X1, Y1, X2 and Y2 is further connected with a corresponding group of control switches 54' and a corresponding group of ADC units 52', wherein each first connector 60' is connected with the second connector 70' and a corresponding group of ADC units 52' through a corresponding group of bidirectional switching switches 55'. The second cable 25' has 8 wires, including 4 five-core wires 1-4 respectively electrically connected with the corresponding 5-way AC power lines 57' and used for transmitting different AC signals, a wire 5 electrically connected with the data receiving line RX' of the first communication unit 56', a wire 6 electrically connected with the data sending line TX' of the first communication unit 56', a wire 7 electrically connected with the VCC power line of the first power module 58', and a wire 8 electrically connected with the GND line of the first power module 58'. The second connector 70' is connected with the first communication unit 56' through the data receiving line RX' and the data sending line TX', the VCC pin of the second connector 70' is connected with the VCC power line of the first power module 58', the GND pin of the second connector 70' is connected with the GND line of the first power module 58' and grounded, and the VCC pin of the second connector 70' is further connected with the corresponding group of voltage dividing resistors 53' and the corresponding group of ADC units 52' through the VCC power line of the first power module 58'.

[0317] Reference Figure 18 to Figure 20 and Figure 8The second connector 70' is electrically connected to the second power supply module 32' and the second controller 37'. The VCC pin of the second connector 70' is also electrically connected to the VCC power supply line of the second power supply module 32', and the GND pin of the second connector 70' is grounded through the GND line of the second power supply module 32'. The second power supply module 32' is also connected to and supplies power to the second controller 37' and the alternating current signal generator 39'. The second communication unit 38' is electrically connected to the wire 5 of the second connector 70' through its data receiving line RX' and is electrically connected to the wire 6 of the second connector 70' through its data sending line TX', thereby realizing information interaction between the electric field generator 30' and the adapter 20'. The second controller 37' is also electrically connected to the second communication unit 38', the alternating current signal generator 39', and the multiple groups of power supply switches 40'. The second controller 37' is configured to control the opening and closing of each power supply switch 40' in each group of power supply switches 40' and adjust the related parameters of the different alternating electric signals applied by the alternating current signal generator 39' according to the relevant digital signals received by the second communication unit 38' from the adapter 20'. The alternating current signal generator 39' is electrically connected to the wires 1 to 4 of the second connector 70' through the multiple groups of power supply switches 40'. Each group of power supply switches 40' includes multiple power supply switches 40', and the multiple groups of power supply switches 40' are arranged one-to-one corresponding to the multiple electrode pieces 13'. Each group of power supply switches 40' is electrically connected to the corresponding wire 1, 2, 3, or 4 of the second connector 70' through a five-core alternating current power supply line 41-1', 41-2', 41-3', or 41-4', and is electrically connected to the corresponding electrode piece 13' through the corresponding wire 1, 2, 3, or 4 of the second connector 70', so as to deliver different alternating electric signals to each electrode piece 13'. The alternating current signal generator 39' is electrically connected to the multiple groups of power supply switches 40' through a five-core alternating current power supply line 41'. Specifically, the number of groups of power supply switches 40' of the electric field generator 30' is related to the number of electrode pieces 13'. In the present embodiment, the number of groups of power supply switches 40' is equal to the number of electrode pieces 13' and both are four. The number of power supply switches 40' in each group is related to the number of column groups of the corresponding electrode piece 13'. In the present embodiment, the number of power supply switches 40' in each group is equal to the number of column groups of the corresponding electrode piece 13' and both are five. The multiple groups of power supply switches 40' include a first group of power supply switches 40-1', a second group of power supply switches 40-2', a third group of power supply switches 40-3', and a fourth group of power supply switches 40-4', which are respectively and one-to-one electrically connected to the five-core wires 1 to 4 of the second connector 70'. One end of the first group of power supply switches 40-1' is electrically connected to the alternating current signal generator 39' through the five-core alternating current power supply line 41' of the electric field generator 30'.The other end is electrically connected with the corresponding five-core wire 1 transmitting alternating current signals in the second connection 70' through a five-core alternating current power line 41-1', and is electrically connected with the five-way alternating current power line 57' at the port X1' of the adapter 20' through the five-core wire 1 of the second connector 70', the five-way alternating current power line 57' at the port X1' of the adapter 20' is electrically connected with the first connector 60', and the first connector 60' at the port X1' of the adapter 20' is electrically connected with the corresponding electrode sheet 13', so as to control whether the alternating current signal generator 39' supplies different alternating current signals to the electrode units 33' in the corresponding five column groups of the electrode sheet 13' electrically connected to the port X1' of the adapter 20' through the five-way alternating current power line 57'. The other end is electrically connected with the corresponding five-core wire 2 transmitting alternating current signals in the second connection 70' through a five-core alternating current power line 41-2', and is electrically connected with the five-way alternating current power line 57' at the port Y1' of the adapter 20' through the five-core wire 2 of the second connector 70', the five-way alternating current power line 57' at the port Y1' of the adapter 20' is electrically connected with the first connector 60', and the first connector 60' at the port Y1' of the adapter 20' is electrically connected with the corresponding electrode sheet 13', so as to control whether the alternating current signal generator 39' supplies different alternating current signals to the electrode units 33' in the corresponding five column groups of the electrode sheet 13' electrically connected to the port Y1' of the adapter 20' through the five-way alternating current power line 57'. The other end is electrically connected with the corresponding five-core wire 3' transmitting alternating current signals in the second connection 70' through a five-core alternating current power line 41-3', and is electrically connected with the five-way alternating current power line 57' at the port X2' of the adapter 20' through the five-core wire 3' of the second connector 70', the five-way alternating current power line 57' at the port X2' of the adapter 20' is electrically connected with the first connector 60', and the first connector 60' at the port X2' of the adapter 20' is electrically connected with the corresponding electrode sheet 13', so as to control whether the alternating current signal generator 39' supplies different alternating current signals to the electrode units 33' in the corresponding five column groups of the electrode sheet 13' electrically connected to the port X2' of the adapter 20' through the five-way alternating current power line 57'. The other end is electrically connected with the corresponding five-core wire 4' transmitting alternating current signals in the second connection 70' through a five-core alternating current power line 41-4', and is electrically connected with the five-way alternating current power line 57' at the port Y2' of the adapter 20' through the five-core wire 4' of the second connector 70', the five-way alternating current power line 57' at the port Y2' of the adapter 20' is electrically connected with the first connector 60', and the first connector 60' at the port Y2' of the adapter 20' is electrically connected with the corresponding electrode sheet 13', so as to control whether the alternating current signal generator 39' supplies different alternating current signals to the electrode units 33' in the corresponding five column groups of the electrode sheet 13' electrically connected to the port Y2' of the adapter 20' through the five-way alternating current power line 57'.The other end is electrically connected to the corresponding five-core wire 4' of the second connector 70' for transmitting alternating electric signals and is electrically connected to the five-way alternating power line 57' of the adapter 20' at the port Y2' through the five-core wire 4 of the second connector 70' and the five-way alternating power line 57' of the adapter 20' at the port Y2', the five-way alternating power line 57' of the adapter 20' at the port Y2' is electrically connected to the corresponding electrode sheet 13', so as to control whether the alternating signal generator 39' supplies different alternating electric signals to the electrode units 33' in the corresponding five columns of the electrode sheet 13' electrically connected to the adapter 20' at the port Y1'.

[0318] The working principle of the tumor electric field treatment system 100' will be described in detail below. Figure 8 The working principle of the tumor electric field treatment system 100' will be described in detail below.

[0319] It should be noted that the working principle of temperature acquisition of the tumor electric field treatment system 100' is the same as that of the tumor electric field treatment system 100, which will not be described here.

[0320] The working principle of the alternating electric signal application of the tumor electric field treatment system 100' is similar to that of the tumor electric field treatment system 100, except that the tumor electric field treatment system 100' can apply different alternating electric signals to different column groups of electrode units 33 at the same time, which is more flexible.

[0321] Specifically, when it is necessary to apply alternating electric signals to each electrode unit 33' of an electrode sheet 13', the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input end 2 of each bidirectional switch 55' of a group of bidirectional switches 55' electrically connected to the electrode sheet 13' to be conductive, the signal acquisition end 1 to be disconnected, and controls a group of power supply switches 40' electrically connected to the electrode sheet 13' to be conductive, at this time, the second controller 37' of the electric field generator 30' controls the alternating signal generator 39' to apply different alternating electric signals to each column group of electrode units 33' of the electrode sheet 13' through different alternating power lines 57', and the voltage or current of the different alternating electric signals applied can be adjusted. That is, the switching unit (not numbered) is configured to switch the two-way signal line 19 corresponding to at least two column groups to be connected to different alternating power lines 57', so that each electrode unit 33 of each column group is respectively applied with different alternating electric signals based on different alternating power lines 57'.

[0322] It should be noted that in other embodiments, the different alternating electric signals applied to the partial electrode units 33' of the electrode sheet 13' at the same time period can also be realized by the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controlling the group of bidirectional switch 55' electrically connected to the electrode sheet 13'. For example, the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls the signal input end 2 of the first bidirectional switch 55-1' of the group of bidirectional switch 55' electrically connected to the electrode sheet 13' to be on, the signal collection end 1 to be off, and controls the power supply switch 40' corresponding to the first bidirectional switch 55-1' of the group of power supply switch 40' electrically connected to the electrode sheet 13' to be on. At this time, the second controller 37' of the electric field generator 30' controls the alternating current signal generator 39' to apply alternating electric signals to the first column group of electrode units 33-1', the electrode unit 33-6', the electrode unit 33-11', and the electrode unit 33-16' of the electrode sheet 13' through the corresponding alternating power line 57', and the voltage or current of the applied alternating electric signals can be adjusted. It should be noted that in other embodiments, different alternating electric signals can also be applied to two column groups, three column groups or four column groups of electrode units 33 at the same time period, which will not be described in detail here.

[0323] It should be noted that the control switch 54' electrically connected to the multiple ground lines 18' of the electrode sheet 13' and the bidirectional switch 55' electrically connected to the multiple dual-purpose signal lines 19' of the electrode sheet 13' in the embodiments of the present application are all arranged in the adapter 20', but in other embodiments, the control switch 54' electrically connected to the ground line 18' and the bidirectional switch 55' electrically connected to the dual-purpose signal line 19' can also be arranged on the electrode sheet 13' or in the electric field generator 30', which will not be described here. In addition, the ADC unit 52' arranged in the adapter 20' can also be arranged in the electric field generator 30' and directly controlled by the second controller 37'.

[0324] The tumor electric field treatment system 100' can realize real-time and comprehensive monitoring of the temperature of all electrode units 33' on the electrode sheet 13' without increasing the weight of the electrode sheet 13' and the core of the first cable 15' electrically connected with the electrode sheet 13', and then can judge whether the electrode sheet 13' is qualified according to the obtained temperature detection signal; or can judge whether the temperature detection unit 35' of the electrode sheet 13' is faulty or abnormal according to the obtained temperature detection signal, and judge whether the electrode sheet 13' needs to be replaced based on the number of temperature detection units 35' that are faulty or abnormal; or can identify the type of the electrode sheet 13' according to the obtained temperature detection signal when the electrode sheet 13' is qualified; or can judge whether the electrode unit 33' of the electrode sheet 13' is over-temperature according to the obtained temperature detection signal when the electrode sheet 13' is qualified, and then control the alternating electric signal applied to the electrode sheet 13' or the corresponding column electrode unit 33' of the electrode sheet 13' to avoid patient body surface low-temperature scalding when tumor treatment is performed through the electrode sheet 13'. In addition, the substrate 31' of the electrode sheet 13' of the present application is electrically connected to the same electrode unit 33' and the signal end 35-2' of the corresponding temperature detection unit 35' through the same dual-purpose signal line 19', which not only realizes that the dual-purpose signal line 19' can transmit alternating electric signals and direct current electric signals for temperature signal collection and collected temperature detection signals, but also greatly reduces the number of conductive traces (ground line 18', dual-purpose signal line 19') arranged thereon, reduces the wiring difficulty of the substrate 31', simplifies the manufacturing process, reduces the weight of the substrate 31', and reduces the manufacturing cost. The electrode sheet 13' of the present application can also realize switching between applying alternating electric signals for tumor treatment and transmitting direct current electric signals for temperature collection and transmitting collected temperature detection signals through the combination control of the control switch 54' electrically connected with the ground line 18' arranged thereon and the bidirectional switching switch 55' electrically connected with the dual-purpose signal line 19'.

[0325] Specifically, when it is required to apply alternating electric signals to the patient through each electrode unit 33' of a certain electrode sheet 13', the first controller 51' of the adapter 20' or the second controller 37' of the electric field generator 30' controls all the control switches 54' in the group of control switches 54' corresponding to the electrode sheet 13' to be turned off, while controlling all the bidirectional switching switches 55' in the group of bidirectional switching switches 55' corresponding to the electrode sheet 13' to be switched to the signal input end 2, so that the signal collection end 1 of the bidirectional switching switches 55' is turned off and the signal input end 2 is turned on, realizing that each two-way signal line 19' of the electrode sheet 13' is electrically connected to the multi-way alternating power line 57' corresponding to the electrode sheet 13' of the adapter 20', so that the same or different alternating electric signals are transmitted to each electrode unit 33' of the electrode sheet 13'. When the temperature detection signal of the temperature detection unit 35' corresponding to all the electrode units 33' of the electrode sheet 13' detected is far below the preset temperature threshold value stored in the electric field generator 30' or the adapter 20', the electric field generator 30' controls the alternating signal generator 39 to continue generating alternating electric signals with increased voltage or current amplitude or unchanged voltage or current amplitude through the second controller 37', and then transmits the alternating electric signals to the corresponding electrode sheet 13' through the corresponding multi-way alternating power line 57' of the adapter 20', so that the electrode sheet 13' continues to apply alternating electric signals; when the temperature detection signal of the temperature detection unit 35' corresponding to all the electrode units 33' of the electrode sheet 13' detected is lower than but close to the preset temperature threshold value stored in the electric field generator 30' or the adapter 20', the electric field generator 30' can reduce the voltage or current of the alternating electric signals generated by the alternating signal generator 39' through the second controller 37', and then reduce the voltage or current of the alternating electric signals applied to the electrode sheet 13'; when it is detected that the temperature detection signal of the temperature detection unit 35' corresponding to an electrode unit 33' of a certain electrode sheet 13' is greater than the preset temperature threshold value, the electric field generator 30' controls the group of power supply switches 40' electrically connected to the electrode sheet 13' to be turned off through the second controller 37', so as to stop applying alternating electric signals to the electrode sheet 13'; or the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls all the bidirectional switching switches 55' in the group of bidirectional switching switches 55' electrically connected to the electrode sheet 13' to be switched from the signal input end 2 to the signal collection end 1, that is, controls all the bidirectional switching switches 55' in the group of bidirectional switching switches 55' electrically connected to the electrode sheet 13' to be turned on at the signal collection end 1 and turned off at the signal input end 2, so as to stop applying alternating electric signals to the electrode sheet 13'.or, when detecting that the temperature detection signal of a temperature detection unit 35' corresponding to an electrode unit 33' of an electrode sheet 13' is greater than a preset temperature threshold, the second controller 37' of the electric field generator 30' controls a group of power supply switches 40' electrically connected to the electrode sheet 13' to continue conducting, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' controls a two-way switch 55' electrically connected to the electrode unit 33' of the electrode sheet 13' to switch from the signal input end 2 to the signal collection end 1, and the second controller 37' of the electric field generator 30' or the first controller 21' of the adapter 20' simultaneously controls the remaining two-way switches 55' electrically connected to the electrode units 33' of the electrode sheet 13' whose temperature detection signals do not exceed the preset temperature threshold and the electrode units 33' of different columns from the electrode units 33' whose temperature detection signals exceed the preset temperature threshold to continue to keep electrical connection with the respective signal input end 2, to stop applying alternating electric signals to all electrode units 33' in the column where the electrode unit 33' whose temperature detection signal exceeds the preset temperature threshold is located, and continue to apply alternating electric signals to the remaining column electrode units 33' whose temperature detection signals do not exceed the preset temperature threshold, and the alternating electric signals applied to the remaining column electrode units 33' can be the same or different, for example, the column whose temperature detection signal does not exceed the preset temperature threshold but is closer to the preset temperature threshold continues to be applied in a manner of reducing the voltage or current amplitude of the alternating electric signal, and the column whose temperature detection signal does not exceed the preset temperature threshold but is farther away from the preset temperature threshold continues to be applied in a manner of increasing the voltage or current amplitude of the alternating electric signal. Thus, the tumor electric field treatment system 100' realizes the alternating electric signal application control method based on the temperature detection signal.

[0326] It should be noted that the alternating electric signal application method, electrode sheet temperature detection method, electrode sheet temperature anomaly detection method, control method, and electrode sheet type identification method of the tumor electric field treatment system 100' of the present embodiment are similar to the control method of the tumor electric field treatment system 100 described above, and the difference lies in that the tumor electric field treatment system 100' of the present embodiment can also apply different alternating electric signals, such as different voltages or currents, to the electrode units 33' in each region (i.e., each column group) at the same time according to the temperature of the electrode units 33' in each region, to prevent the electrode units 33' in the corresponding region from exceeding the preset temperature threshold, so as to apply the electric field for a long time without interruption and improve the treatment effect.

[0327] Specifically, the tumor electric field treatment system 100' of the present embodiment can determine the temperature at each electrode unit 33' in the electrode sheet 13' by using the electrode sheet temperature detection method shown in Figure 9 , and details are described in Figure 9 , which will not be repeated here.

[0328] The tumor electric field therapy system 100' of the embodiment can adopt the electrode sheet temperature abnormality detection method as shown in Figure 21 The electrode sheet temperature abnormality detection method determines whether the electrode sheet 13' is abnormal, and specific reference is made to the electrode sheet temperature abnormality detection method as shown in Figure 11 which will not be repeated here.

[0329] The tumor electric field therapy system 100' of the embodiment can adopt the control method of the tumor electric field therapy system as shown in Figure 11 The control method of the tumor electric field therapy system controls the alternating electric signal strength applied to the electrode unit 33', and specifically includes the following steps:

[0330] Step 210': Control the switching unit to connect the two-purpose signal line 19' corresponding to at least one column group in the corresponding electrode sheet 13' to the corresponding temperature sampling point.

[0331] Step 220': Control the control switch 54' corresponding to each row group to sample the analog temperature signal of the corresponding electrode unit 33' based on the corresponding temperature sampling point, so as to determine the temperature detection signal of each electrode unit 33' in each electrode sheet 13'.

[0332] Step 240': Control the alternating electric signal strength applied to the electrode unit 33' according to the temperature detection signal.

[0333] Specifically, in the case where it is determined that the electrode sheet 13' does not need to be replaced, the alternating electric signal applied to each electrode unit 33' in the electrode sheet 13' is controlled or adjusted according to the temperature detection signal detected by the temperature detection unit 35' corresponding to each electrode unit 33' in the electrode sheet 13' obtained.

[0334] In some embodiments, the control of the alternating electric signal strength applied to the electrode unit 33' according to the temperature detection signal in step 240' specifically includes the following steps:

[0335] Step 241': Compare the temperature at each electrode unit 33' in the electrode sheet 13' with a preset temperature threshold according to the temperature detection signal.

[0336] Step 242': Control the alternating electric signal strength according to the comparison result.

[0337] In some embodiments, the control of the alternating electric signal strength according to the comparison result in step 242' specifically includes:

[0338] Step 2421': stop applying the alternating electric signal to the electrode units 33' of the electrode sheet 13' in the case that the temperature at at least one electrode unit 33' exceeds the preset temperature threshold. Specifically, stop applying the alternating electric signal to the electrode units 33' of the electrode sheet 13' in the case that there is a temperature detection signal exceeding the preset temperature threshold among the temperature detection signals of all the electrode units 33' of the electrode sheet 13'. Continue applying the alternating electric signal to the electrode units 33' of the electrode sheet 13' in the case that none of the temperature detection signals of the electrode units 33' of the electrode sheet 13' exceeds the preset temperature threshold.

[0339] In some embodiments, the step 2421' of stopping applying the alternating electric signal to the electrode units 33' of the electrode sheet 13' specifically comprises: stopping applying the alternating electric signal to all the electrode units 33' of the electrode sheet 13'; or stopping applying the alternating electric signal to all the electrode units 33' of the column group in which the electrode units 33' exceeding the preset temperature threshold are located.

[0340] Further, in the case of stopping applying the alternating electric signal to all the electrode units 33' of the column group in which the electrode units 33' exceeding the preset temperature threshold are located, continue applying the alternating electric signal to the electrode units 33' of other column groups of the electrode sheet 13'. The intensity of the alternating electric signal applied to the electrode units 33' of other column groups of the electrode sheet 13' is respectively adjustable. For example, all the electrode units 33' whose temperature detection signals do not exceed the preset temperature threshold and are located in different columns from the electrode units 33' whose temperature detection signals exceed the preset temperature threshold continue to be applied with the alternating electric signal, and the alternating electric signals applied to different column groups can be the same or different, for example, the smaller the amplitude of the voltage or current of the alternating electric signal applied to the column group closer to the preset temperature threshold but not exceeding the preset temperature threshold, the larger the amplitude of the voltage or current of the alternating electric signal applied to the column group farther from the preset temperature threshold but not exceeding the preset temperature threshold.

[0341] In some other embodiments, the step 242' of controlling the intensity of the alternating electric signal according to the comparison result specifically comprises:

[0342] Step 2422': in the case that the temperature at all the electrode units 33' of the electrode sheet 13' does not exceed the preset temperature threshold, if the temperature at all the electrode units 33' of the electrode sheet 13' does not exceed a first preset temperature, increase the intensity of the alternating electric signal applied to the electrode units 33' of the electrode sheet 13', wherein the first preset temperature is smaller than the preset temperature threshold.

[0343] In the step 2422', the amplitude of the electric field intensity of each column group corresponding to which the intensity of the alternating electric signal is increased can be the same or different, i.e., is respectively adjustable. For example, the larger the amplitude of the voltage or current of the alternating electric signal applied to the column group with the lower highest temperature, the smaller the amplitude of the voltage or current of the alternating electric signal applied to the column group with the higher highest temperature.

[0344] Step 2423': If there is at least one electrode unit 33' in the electrode sheet 13' where the temperature exceeds the first preset temperature and is less than the second preset temperature, the alternating electric signal strength currently applied to the electrode units 33' of the electrode sheet 13' is kept unchanged, in the case that the temperature at all electrode units 33' in the electrode sheet 13' does not exceed the preset temperature threshold.

[0345] In step 2423', keeping the alternating electric signal strength currently applied to the electrode units 33' unchanged specifically includes keeping the alternating electric signal strength currently applied to the first target column group unchanged, where the first target column group is the column group where the temperature of the electrode unit 33' exceeds the first preset temperature and is less than the second preset temperature. That is, only the voltage or current amplitude of the alternating electric signal corresponding to the column group where the temperature exceeds the first preset temperature and is less than the second preset temperature can be kept, and the voltage or current amplitude of the alternating electric signal corresponding to the remaining column groups can still be adjusted according to the temperature of the corresponding column group.

[0346] Step 2424': If there is at least one electrode unit 33' in the electrode sheet 13' where the temperature exceeds the second preset temperature and is less than the preset temperature threshold, the alternating electric signal strength applied to the electrode units 33' of the electrode sheet 13' is reduced, in the case that the temperature at all electrode units 33' in the electrode sheet 13' does not exceed the preset temperature threshold.

[0347] In step 2424', reducing the alternating electric signal strength applied to the electrode units 33' specifically includes reducing the alternating electric signal strength applied to the electrode units 33' of the second target column group, where the second target column group is the column group where the temperature of the electrode unit 33' exceeds the second preset temperature and is less than the preset temperature threshold. That is, only the voltage or current amplitude of the alternating electric signal corresponding to the column group where the temperature exceeds the second preset temperature and is less than the preset temperature threshold can be reduced, and the voltage or current amplitude of the alternating electric signal corresponding to the remaining column groups can still be adjusted according to the temperature of the corresponding column group, for example, kept or increased.

[0348] For example, when the temperature detection signal is far below the preset temperature threshold, the alternating electric signal continues to be applied to each electrode unit 33' of the electrode sheet 13' in a manner that the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' is increased, wherein the voltage or current amplitude of the alternating electric signal applied by different column groups can be the same or different, or the alternating electric signal continues to be applied to each electrode unit 33' of the electrode sheet 13' in a manner that the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' is kept unchanged, wherein the voltage or current amplitude of the alternating electric signal applied by only part of the column groups can be kept unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electric signal continues to be applied to each electrode unit 33' of the electrode sheet 13' in a manner that the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' is kept unchanged, wherein the voltage or current amplitude of the alternating electric signal applied by only part of the column groups can be kept unchanged, or the alternating electric signal continues to be applied to each electrode unit 33' of the electrode sheet 13' in a manner that the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' is reduced, wherein the voltage or current amplitude of the alternating electric signal applied by different column groups can be the same or different.

[0349] In yet some embodiments, the controlling the alternating electric signal strength according to the comparison result in step 242' specifically comprises:

[0350] Step 2425': determining the number of over-temperature column groups in the case that the temperature at the at least one electrode unit 33' exceeds the preset temperature threshold.

[0351] Step 2426': stopping the application of the alternating electric signal to all electrode units 33' of the electrode sheet 13' in the case that the number of over-temperature column groups exceeds a preset number threshold.

[0352] Step 2427': stopping the application of the alternating electric signal to all electrode units 33' of the column group in which the electrode unit 33' exceeding the preset temperature threshold is located in the case that the number of over-temperature column groups does not exceed the preset number threshold.

[0353] Further, in the case that the application of the alternating electric signal to all the electrode units 33' in the column group in which the electrode unit 33' exceeding the preset temperature threshold is located is stopped, the application of the alternating electric signal to the electrode units 33' in other column groups in the electrode sheet 13' is continued. The intensity of the alternating electric signal applied to the electrode units 33' in the other column groups in the electrode sheet 13' is respectively adjustable. For example, all the electrode units 33' in which the temperature detection signal does not exceed the preset temperature threshold and which are in different columns from the electrode unit 33' in which the temperature detection signal exceeds the preset temperature threshold continue to be applied with the alternating electric signal, and the alternating electric signals applied to the different column groups can be the same or different. For example, the smaller the amplitude of the voltage or current of the alternating electric signal applied to the column group closer to the preset temperature threshold but not exceeding the preset temperature threshold, the greater the amplitude of the voltage or current of the alternating electric signal applied to the column group farther from the preset temperature threshold but not exceeding the preset temperature threshold.

[0354] In the case that the number of the over-temperature column groups does not exceed the preset number threshold, if the temperature at each electrode unit 33' in the non-over-temperature column group does not exceed the first preset temperature, the intensity of the alternating electric signal applied to the electrode units 33' in the non-over-temperature column group is increased, wherein the first preset temperature is less than the preset temperature threshold.

[0355] In step 2428', the amplitude of the electric field corresponding to each column group in which the intensity of the alternating electric signal is increased can be the same or different, i.e., respectively adjustable. For example, the greater the amplitude of the voltage or current of the alternating electric signal applied to the column group with the lower highest temperature, the smaller the amplitude of the voltage or current of the alternating electric signal applied to the column group with the higher highest temperature.

[0356] In the case that the number of the over-temperature column groups does not exceed the preset number threshold, if there is at least one electrode unit 33' in the non-over-temperature column group in which the temperature exceeds the first preset temperature and is less than the preset temperature threshold, the intensity of the alternating electric signal currently applied to the electrode units 33' in the non-over-temperature column group is maintained unchanged.

[0357] In step 2429', the maintaining of the intensity of the alternating electric signal currently applied to the electrode units 33' unchanged specifically includes maintaining the intensity of the alternating electric signal currently applied to the first target column group unchanged, wherein the first target column group is the column group in which the temperature of the electrode unit 33' exceeds the first preset temperature and is less than the preset temperature threshold. That is, only the amplitude of the voltage or current of the alternating electric signal corresponding to the column group in which the temperature exceeds the first preset temperature and is less than the preset temperature threshold can be maintained unchanged, and the amplitudes of the voltages or currents of the alternating electric signals corresponding to the remaining column groups can still be adjusted according to the temperatures of the corresponding column groups.

[0358] Step 2430': if there is at least one electrode unit 33' in the non-over-temperature column group whose temperature exceeds the second preset temperature and is less than the preset temperature threshold, reducing the strength of the alternating electric signal applied to the electrode units 33' in the non-over-temperature column group, wherein the second preset temperature is greater than the first preset temperature and less than the preset temperature threshold.

[0359] In step 2430', reducing the strength of the alternating electric signal applied to the electrode units 33' specifically includes: reducing the strength of the alternating electric signal applied to the electrode units 33' in the second target column group, wherein the second target column group is the column group in which the temperature of the electrode unit 33' exceeds the second preset temperature and is less than the preset temperature threshold. That is, the voltage or current amplitude of the alternating electric signal corresponding to the column group whose temperature exceeds the second preset temperature and is less than the preset temperature threshold can be reduced, and the reduced amplitudes can be the same or different, and the amplitudes of the alternating electric signals corresponding to the remaining column groups can still be adjusted according to the temperatures of the corresponding column groups, for example, remain unchanged or increase.

[0360] For example, when the temperature detection signal is far below the preset temperature threshold, the alternating electric signal is continuously applied to each electrode unit 33' of the electrode sheet 13' in a manner of increasing the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13', wherein the amplitudes of the voltages or currents of the alternating electric signals applied by different column groups can be the same or different, or the alternating electric signal is continuously applied to each electrode unit 33' of the electrode sheet 13' in a manner of keeping the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' unchanged, wherein the amplitudes of the voltages or currents of the alternating electric signals applied by only part of the column groups remain unchanged. When the temperature detection signal approaches the preset temperature threshold, the alternating electric signal is continuously applied to each electrode unit 33' of the electrode sheet 13' in a manner of keeping the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13' unchanged, wherein the amplitudes of the voltages or currents of the alternating electric signals applied by only part of the column groups remain unchanged, or the alternating electric signal is continuously applied to each electrode unit 33' of the electrode sheet 13' in a manner of reducing the voltage or current amplitude of the alternating electric signal applied to each electrode unit 33' of the electrode sheet 13', wherein the amplitudes of the voltages or currents of the alternating electric signals applied by different column groups can be the same or different.

[0361] The tumor electric field treatment system 100' of the embodiment can adopt the electrode sheet type identification method shown in FIG. 13, which is specifically described in the electrode sheet type identification method of the first embodiment, and will not be described here again. Figure 22 The tumor electric field treatment system 100' of the embodiment can adopt the electrode sheet type identification method shown in FIG. 13, which is specifically described in the electrode sheet type identification method of the first embodiment, and will not be described here again. Figure 22 The tumor electric field treatment system 100' of the embodiment can adopt the electrode sheet type identification method shown in FIG. 13, which is specifically described in the electrode sheet type identification method of the first embodiment, and will not be described here again.

[0362] The tumor electric field treatment system 100' of the embodiment can adopt the electrode sheet type identification method shown in FIG. 13, which is specifically described in the electrode sheet type identification method of the first embodiment, and will not be described here again. Figure 13The signal control method for the tumor electric field treatment shown controls the control switch 54' and the bidirectional switch 55' electrically connected with the electrode sheet 13' in combination to switch each electrode unit 33' of the electrode sheet 13' between applying an alternating electric signal and collecting a temperature detection signal.

[0363] Referring to Figure 13 The method shown includes:

[0364] Step 310': control the control switch 54' and the bidirectional switch 55' electrically connected with the corresponding electrode sheet 13' in combination to apply an alternating electric signal to each electrode unit 33' of the electrode sheet 13' and perform step 320';

[0365] The application of the alternating electric signal to each electrode unit 33' of the electrode sheet 13' in step 310' specifically includes: simultaneously applying the same or different alternating electric signals to the electrode units 33' in part or all column groups.

[0366] Step 320': control the control switch 54' and the bidirectional switch 55' electrically connected with the electrode sheet 13' in combination to collect the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in rows and perform step 330';

[0367] The collection of the temperature detection signals of each electrode unit 33' of the electrode sheet 13' in rows in step 320' specifically includes: sequentially sampling the temperature detection signals of all electrode units 33' in part or all row groups in all row groups in the same sampling time period; or sequentially sampling the temperature detection signals of part of the electrode units 33' in part or all row groups in all row groups in the same sampling time period.

[0368] Step 330': determine the combination control mode of the control switch 54' and the bidirectional switch 55' electrically connected with the electrode sheet 13' according to the collected temperature detection signals and perform step 340';

[0369] Step 340': control the working state of each electrode unit 33' of the electrode sheet 13' according to the determined combination control mode of the control switch 54' and the bidirectional switch 55'.

[0370] The working state of each electrode unit 33' of the electrode sheet 13' in step 340' includes at least one of: stopping applying the alternating electric signal and continuing to collect the temperature detection signal, and stopping collecting the temperature detection signal and continuing to apply the alternating electric signal. Continuing to apply the alternating electric signal includes: continuing to apply the alternating electric signal in a manner of increasing the voltage or current amplitude of the currently applied alternating electric signal, or continuing to apply the alternating electric signal in a manner of keeping the voltage or current amplitude of the currently applied alternating electric signal unchanged, or continuing to apply the alternating electric signal in a manner of reducing the voltage or current amplitude of the currently applied alternating electric signal. The manner of continuing to apply the alternating electric signal corresponding to different column groups can be the same or different.

[0371] The working state of each electrode unit 33' of the electrode sheet 13' is determined by the temperature detection signal collected thereby. Each electrode unit 33' of the electrode sheet 13' is divided into different regions, and each electrode unit 33' in each region can be cyclically switched between applying the alternating electric signal and collecting the temperature detection signal by controlling the combination of the switch 54' and the bidirectional switching switch 55'. When applying the alternating electric signal, different regions can be the same or different.

[0372] The tumor electric field treatment system 100' of the embodiment can adopt the electrode sheet temperature detection method shown in Figure 14 to Figure 16 For details, refer to ​ which will not be repeated here.

[0373] The tumor electric field treatment system 100' of the embodiment can adopt the alternating electric signal application method for tumor electric field treatment shown in ​ For details, refer to

[0374] The application also provides a tumor electric field treatment system 100 or 100', which includes: at least one pair of the aforementioned electrode sheet 13 or 13'; an electric field generator 30 or 30', the electric field generator 30 or 30' is used to generate an alternating power supply, and transmit the alternating power supply to each electrode sheet 13 or 13' through an alternating power supply line 57 or 57'; a control unit (such as the first controller 51 or 51', or the second controller 37 or 37', etc.), the control unit is used to configure at least one of the switching state of the control switch 54 or 54' and the switching state of the switching unit (not labeled), so as to sample the analog temperature signal detected by the corresponding temperature detection unit 35 or 35' in each row group based on the corresponding temperature sampling point (not labeled), or control the electrode unit 33 or 33' of at least one column group to be applied with the alternating electric signal based on the alternating power supply line 57 or 57'.

[0375] The application also provides a tumor treatment device (not shown), comprising the tumor electric field treatment system 100 or 100' described above.

[0376] The application also provides a computer readable storage medium, which stores a computer program, and the computer program is executed by a processor to implement the electrode temperature detection method described above; or the electrode abnormality detection method described above; or the control method of the tumor electric field treatment system described above; or the electrode type identification method described above.

[0377] The application also provides a tumor electric field treatment adapter 20 or 20', which comprises a first memory (not shown) and a first controller 51 or 51', and the first memory (not shown) stores a computer program, and the computer program is executed by the first controller 51 or 51' to implement the electrode temperature detection method described above; or the electrode abnormality detection method described above; or the control method of the tumor electric field treatment system described above; or the electrode type identification method described above.

[0378] The application also provides a tumor electric field treatment electric field generator 30 or 30', which comprises a second memory (not shown) and a second controller 37 or 37', and the second memory (not shown) stores a computer program, and the computer program is executed by the second controller 37 or 37' to implement the electrode temperature detection method described above; or the electrode abnormality detection method described above; or the control method of the tumor electric field treatment system described above; or the electrode type identification method described above.

[0379] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the application, and not to limit them; although the application has been described in detail with reference to the above embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the above embodiments, or make equivalent replacement to part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the application, and they should be covered in the scope of the claims and the description of the application. Especially, as long as there is no structural conflict, each technical feature mentioned in each embodiment can be combined in any way. The application is not limited to the specific embodiments disclosed in the text, but includes all technical solutions falling within the scope of the claims.

Claims

1. A tumor electric field therapy system, characterized in that, include: An electrode sheet includes multiple electrode units and multiple temperature detection units. Each electrode unit can be subjected to an alternating electrical signal. Each temperature detection unit is configured to detect the temperature at each electrode unit. The signal terminals of each temperature detection unit are short-circuited to the corresponding electrode unit. The multiple temperature detection units are configured in the circuit as multiple row groups and multiple column groups. The ground terminals of the temperature detection units in the same row group are short-circuited to the same grounding line. The ground terminals of the temperature detection units in different row groups are connected in parallel through different grounding lines. The signal terminals of the temperature detection units in the same column group are short-circuited to the same dual-purpose signal line. The signal terminals of the temperature detection units in different column groups are connected in parallel through different dual-purpose signal lines. The grounding line is configured to ground the ground terminals of the temperature detection units in the corresponding row group. The dual-purpose signal line is configured to receive an AC signal to transmit an AC signal to the electrode units in the corresponding column group or to receive a DC signal to transmit a DC signal to the signal terminals of the temperature detection units in the corresponding column group. as well as The controller is configured to combine control of each of the grounding wires and each of the dual-purpose signal lines so that (1) when a DC signal is connected to the dual-purpose signal line, each of the grounding wires is sequentially turned on so that the temperature detection signals detected by each of the temperature detection units are collected row by row; (2) when an AC signal is connected to the dual-purpose signal line, the alternating signal is transmitted to each of the electrode units in the corresponding column group through the dual-purpose signal line.

2. The tumor electric field therapy system according to claim 1, characterized in that, The controller is also configured to: The operating state of each electrode unit is determined based on the temperature detection signals; or The strength of the transmitted alternating electrical signal is controlled or adjusted according to the temperature detection signals described above; or The electrode sheet is judged to be qualified based on the temperature detection signals; or Based on the temperature detection signals, determine whether the temperature detection unit is abnormal or faulty; or The electrode type is identified based on the acquired temperature detection signals; or The electrode unit is over-temperature determined based on the temperature detection signals; or The electrode replacement is determined based on the temperature detection signals.

3. The tumor electric field therapy system according to claim 1, characterized in that, The controller is configured to have a preset temperature threshold and is set to: Compare each of the temperature detection signals with the preset temperature threshold; and The operating state of each electrode unit is determined based on the comparison results, or the strength of the alternating electrical signal transmitted to each electrode unit is controlled.

4. The tumor electric field therapy system according to claim 3, characterized in that, The comparison result is either exceeding a preset temperature threshold or not exceeding a preset temperature threshold. The electrode unit corresponding to the temperature detection signal exceeding the preset temperature threshold is an over-temperature electrode unit, and the electrode unit corresponding to the temperature detection signal not exceeding the preset temperature threshold is a non-over-temperature electrode unit.

5. The tumor electric field therapy system according to claim 4, characterized in that, The controller is also configured to: When at least one of the aforementioned overheating electrode units exists, control each of the dual-purpose signal lines to stop transmitting AC signals to each of the electrode units; or When at least one of the overheating electrode units exists, the dual-purpose signal line electrically connected to the overheating electrode unit is controlled to stop transmitting AC signals to each of the electrode units in the corresponding column group, and at the same time, the dual-purpose signal line corresponding to the column group consisting entirely of non-overheating electrode units is controlled to continue transmitting AC signals to each of the electrode units in the corresponding column group.

6. The tumor electric field therapy system according to claim 4, characterized in that, The controller is further configured to have a preset quantity threshold and to: When at least one of the aforementioned overheat electrode units exists, the number of overheat arrays is determined; and When the number of the overheated arrays exceeds a preset threshold, control each of the dual-purpose signal lines to stop transmitting AC signals to all electrode units of the electrode sheet; or When the number of the overheated arrays does not exceed a preset threshold, the dual-purpose signal line electrically connected to the overheated electrode unit is controlled to stop transmitting AC signals to each electrode unit in the overheated array, and the dual-purpose signal line corresponding to the non-overheated array is controlled to transmit AC signals to each electrode unit in the remaining arrays of the electrode sheet.

7. The tumor electric field therapy system according to claim 6, characterized in that, The intensity of the AC signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is adjustable.

8. The tumor electric field therapy system according to claim 6, characterized in that, The intensity of the AC signal transmitted to each of the electrode units in the remaining columns of the electrode sheet is adjustable.

9. The tumor electric field therapy system according to claim 4, characterized in that, The controller is configured to have a first preset temperature that is less than the preset temperature threshold, wherein the temperature is: Compare each of the temperature detection signals with the first preset temperature; and When all the temperature detection signals are lower than the first preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with increased voltage or current amplitude to each of the electrode units; or When all the temperature detection signals are less than the preset temperature threshold and at least one of the temperature detection signals exceeds the first preset temperature of the electrode unit, the alternating electrical signal with a constant voltage or current amplitude is transmitted from each of the dual-purpose signal lines to each of the electrode units; or When at least one of the aforementioned over-temperature electrode units is present, the dual-purpose signal line is controlled to stop transmitting the AC signal to the electrode unit.

10. The tumor electric field therapy system according to claim 9, characterized in that, Stopping the transmission of AC signals to the electrode units includes: stopping the transmission of AC signals to all the electrode units; or stopping the transmission of AC signals to each of the electrode units in the same column as the overheating electrode unit, while continuing to transmit AC signals to each of the electrode units in the remaining columns.

11. The tumor electric field therapy system according to claim 4, characterized in that, The controller has a first preset temperature and a second preset temperature, wherein the first preset temperature is less than the second preset temperature and the second preset temperature is less than a preset temperature threshold. When none of the temperature detection signals exceed the preset threshold, the controller is further configured to: Compare each of the temperature detection signals with the first preset temperature; When none of the temperature detection signals exceed the first preset temperature, control each dual-purpose signal line to transmit an AC signal with increased voltage or current amplitude to each electrode unit; When at least one of the temperature detection signals exceeds the first preset temperature, the temperature detection signal exceeding the first preset temperature is compared with the second preset temperature; When none of the temperature detection signals exceed the second preset temperature, control each of the dual-purpose signal lines to transmit an AC signal with a constant voltage or current amplitude to each of the electrode units; When at least one of the temperature detection signals exceeds the second preset temperature, the alternating electrical signal with reduced voltage or current amplitude is transmitted from each of the dual-purpose signal lines to each of the electrode units.

12. The tumor electric field therapy system according to claim 4, characterized in that, The controller is configured to: When the temperature detection signals are all much lower than the preset temperature threshold, the dual-purpose signal line is controlled to transmit an alternating electrical signal with an increased or unchanged voltage or current amplitude to the electrode unit. When the temperature detection signal approaches the preset temperature threshold, the dual-purpose signal line is controlled to transmit an alternating electrical signal with a constant or reduced voltage or current amplitude to the electrode unit.

13. The tumor electric field therapy system according to claim 1, characterized in that, The controller is configured to: Determine the regions where each of the electrode units requires the application of an AC signal; and The control system transmits AC signals to each of the electrode units that require AC signals, using the dual-purpose signal line corresponding to the area it is located.

14. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, Each column of electrode units is connected to the same alternating power supply line via a corresponding dual-purpose signal line.

15. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, The electrode units of each column are connected to different alternating power supply lines via corresponding dual-purpose signal lines.

16. The tumor electric field therapy system according to any one of claims 1-13, characterized in that, It also includes an AC signal generator electrically connected to the controller, the controller being configured to control the intensity of the AC signal generated by the AC signal based on each of the temperature detection signals.

17. The tumor electric field therapy system according to claim 16, characterized in that, The controller includes a power supply switch electrically connected to the AC signal generator, and controls the closing and opening of the power supply switch.

18. The tumor electric field therapy system according to claim 17, characterized in that, The power supply switch is one; or the power supply switch is multiple and its number is equal to the number of the column groups.

19. The tumor electric field therapy system according to claim 16, characterized in that, It includes multiple control switches and multiple bidirectional switching switches. Each grounding wire is grounded through a control switch connected in series with it, and each dual-purpose signal line is connected to a DC signal or an AC signal through a bidirectional switching switch connected in series with it.

20. The tumor electric field therapy system according to claim 16, characterized in that, The controller is configured to: When the dual-purpose signal line is connected to an AC signal, all of the aforementioned grounding lines are disconnected; or When a DC signal is connected to the dual-purpose signal line, the grounding lines are controlled to be turned on sequentially in a time-sharing manner.

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