Mixed reaction device for research and development of photodynamic antibacterial photosensitizer

Abstract

The invention relates to the technical field of photosensitizer production, and provides a mixing reaction device for photodynamic antibacterial photosensitizer research and development, the mixing reaction device comprises a mixing barrel, and the opposite side of the inner wall of the mixing barrel is rotatably connected with a stirring rod. The controller controls the motor to start, the output shaft of the motor drives the crank and the connecting strip to rotate, the round rod drives the grinding plate with holes to move left and right in a reciprocating mode, the crank rotates synchronously, the second synchronous wheel is driven to rotate, the charging barrel can be driven to rotate, and under cooperation of left-right reciprocating movement of the grinding plate with the holes and rotation of the charging barrel, the grinding plate with the holes is driven to rotate. The crystallization solid raw materials are crushed and ground into powder and fall down through the grinding plate with the holes, the powder-shaped raw materials are added into the mixing barrel, in this way, the crystallization solid raw materials can be conveniently ground, the subsequent mixing reaction of the crystallization solid raw materials and the liquid and powder-shaped raw materials is facilitated, and therefore the fusion speed is increased; further, the production efficiency of the photodynamic antibacterial photosensitizer is improved.

Description

Technical Field

[0001] This invention relates to the field of photosensitizer production technology, and in particular to a mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizers. Background Technology

[0002] Photodynamic antibacterial photosensitizers are special molecules that generate reactive oxygen species under light conditions, used to kill or inhibit pathogenic microorganisms. Their working principle is based on photodynamic antibacterial therapy technology. Through the synergistic effect of photosensitizers, specific wavelengths of light, and molecular oxygen, singlet oxygen or other free radicals with strong oxidizing capabilities are generated, damaging the bacterial cell membrane, proteins, and DNA, thus achieving highly efficient sterilization.

[0003] In the prior art, for example, Chinese Patent No. CN112387165A discloses a mixing reaction device for the research and development of photodynamic antibacterial photosensitizers, including rollers, mounting frames, support frames, discharge shafts, tanks, and bearings. The support frames are located at the top of the mounting frames, and the bottom end of the support frames is fixedly connected to the top end of the mounting frames. A connecting block is provided between two adjacent support frames, and the connecting block is rotatably connected to the top end of the support frame. A discharge shaft is fixedly connected to one end of the tank, and the discharge shaft is rotatably connected to the connecting block through the bearing. A first gear is sleeved on the outer end of the discharge shaft, and a first motor is fixedly connected to the top end of the connecting block. A second gear is sleeved on the output end of the first motor, and the first gear and the second gear are meshed. The first motor drives the second gear to rotate, and under the transmission of the first gear and the second gear, the tank can be rotated clockwise. At this time, the raw materials can be mixed under the action of the inclined plate. Under the action of the second motor, the stirring shaft can be rotated counterclockwise.

[0004] While the above scheme has the advantages mentioned above, its disadvantages are as follows: Although the first motor can drive the second gear to rotate, and the transmission between the first and second gears can drive the tank to rotate clockwise, thus mixing the raw materials under the action of the inclined plate, and the second motor can drive the stirring shaft to rotate counterclockwise to enhance the mixing capacity of the device, the raw materials used in the research and development of photodynamic antibacterial photosensitizers are of various types, including liquid, powder, and crystalline solid. The fusion speed of crystalline solid raw materials during the mixing reaction is relatively slow, which leads to a decrease in the production efficiency of photodynamic antibacterial photosensitizers. Summary of the Invention

[0005] The purpose of this invention is to solve the problem in the prior art where, although the first motor drives the second gear to rotate, and the transmission between the first and second gears drives the tank to rotate clockwise, the raw materials can be mixed under the action of the inclined plate. At the same time, the second motor drives the stirring shaft to rotate counterclockwise, thereby enhancing the mixing capacity of the device. However, since there are many types of raw materials used in the research and development of photodynamic antibacterial photosensitizers, including liquid, powder, and crystalline solids, the fusion speed of crystalline solid raw materials is slow during the mixing reaction, resulting in a decrease in the production efficiency of photodynamic antibacterial photosensitizers.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a mixing reaction device for the research and development of photodynamic antibacterial photosensitizer, comprising: a mixing tank, a stirring rod rotatably connected to opposite sides of the inner wall of the mixing tank, a U-shaped plate fixedly connected to the top of the mixing tank, a motor fixedly connected to the top of the U-shaped plate, a crank fixedly connected to the output end of the motor, the crank being fixedly connected to the stirring rod, a connecting strip rotatably connected to the outer surface of the crank, a guide frame fixedly connected to the top of the mixing tank, a perforated grinding plate slidably connected to the opposite side of the guide frame near the top inner wall, a round rod fixedly connected to the top of the connecting strip near the perforated grinding plate, the round rod being rotatably connected to the perforated grinding plate, a material cylinder rotatably connected to the top of the guide frame, and multiple round holes being opened at the bottom of the material cylinder.

[0007] Preferably, a second synchronous pulley is fixedly connected to the outer surface of the crank, a first synchronous pulley is fixedly connected to the outer surface of the barrel, and a synchronous belt is meshed between the outer surfaces of the first and second synchronous pulleys.

[0008] Preferably, a return groove is provided on each of the opposite sides of the guide frame, and an inclined frame is fixedly connected to each of the opposite sides of the guide frame.

[0009] Preferably, a sealing plate is slidably connected to the bottom side of the guide frame, and an electric telescopic rod is fixedly installed on the top of the mixing tank, with one end of the electric telescopic rod fixedly connected to one side of the sealing plate.

[0010] Preferably, one end of the stirring rod is fixedly connected to a pneumatic rotary joint, and multiple air guide tubes are fixedly connected in a circumferential array on the outer surface of the pneumatic rotary joint. Multiple aeration holes are equidistantly opened on the outer surface of the air guide tubes.

[0011] Preferably, an air inlet pipe is fixedly connected to the bottom of the mixing tank, the air inlet pipe is rotatably connected to a pneumatic rotary joint, the air inlet pipe is connected to the air inlet of the pneumatic rotary joint, and the air guide pipe is connected to the air outlet of the pneumatic rotary joint.

[0012] Preferably, a pressure relief valve, a pressure sensor, and a temperature sensor are fixedly connected to the top of the mixing tank. The pressure relief valve is connected to the mixing tank, and one end of the pressure sensor and the temperature sensor extends into the interior of the mixing tank.

[0013] Preferably, an insulation sleeve is fixedly connected to the outer surface of the mixing tank, and multiple heating rings are fixedly connected at equal intervals to the inner wall of the insulation sleeve.

[0014] Preferably, a feed hopper is fixedly connected to the top of the mixing tank, and the feed hopper is connected to the mixing tank. A discharge pipe is fixedly connected to the bottom of the mixing tank, and the discharge pipe is connected to the mixing tank. A valve is fixedly connected to the outer surface of the discharge pipe.

[0015] Compared with the prior art, the advantages and positive effects of the present invention are as follows:

[0016] 1. This invention uses a controller to start a motor, causing its output shaft to drive a crank and connecting bar to rotate. This causes a round rod to move a perforated grinding plate back and forth. Simultaneously, the rotation of the crank drives a second synchronous wheel to rotate. Then, with the cooperation of the second synchronous wheel, the synchronous belt, and the first synchronous wheel, the material cylinder can be rotated. This allows the crystalline solid raw material inside the cylinder to contact the perforated grinding plate through the round hole. With the cooperation of the reciprocating movement of the perforated grinding plate and the rotation of the material cylinder, the crystalline solid raw material is crushed and ground into powder, which falls downward through the perforated grinding plate. The controller then controls the electric telescopic rod to retract, allowing the sealing plate to move out from inside the guide frame, and the powdered raw material to be added to the mixing tank. This facilitates the grinding of the crystalline solid raw material and makes it easier for the crystalline solid raw material to be mixed and reacted with the liquid and powdered raw materials, thereby increasing the fusion speed and improving the efficiency of photodynamic antibacterial photosensitizer production.

[0017] 2. In this invention, the rotation of the stirring rod drives the pneumatic rotary joint and the air guide pipe to rotate. With the cooperation of the rotation of the stirring rod and the aeration holes, the raw materials are mixed and stirred. At the same time, nitrogen gas is delivered to the raw materials through the aeration holes to produce an aeration effect. This allows the raw materials to be mixed more thoroughly, thereby improving the quality of the photodynamic antibacterial photosensitizer production.

[0018] 3. In this invention, the gas delivery end of an external nitrogen delivery system is connected to the air inlet pipe, and nitrogen is delivered to the air inlet pipe. The nitrogen is then delivered to the mixing tank in sequence through a pneumatic rotary joint, a gas guide pipe, and an aeration hole. Since nitrogen is less dense than air, air can be discharged through the feed hopper. This provides a better mixing and reaction environment for the raw materials of photodynamic antibacterial photosensitizer research and development. Attached Figure Description

[0019] Figure 1A side view of a mixing reaction device for the research and development of photodynamic antibacterial photosensitizer provided by the present invention;

[0020] Figure 2 A bottom view of the mixing reaction device for the research and development of photodynamic antibacterial photosensitizer provided by the present invention;

[0021] Figure 3 A partial cross-sectional structural diagram of a mixing reaction device for the research and development of photodynamic antibacterial photosensitizer provided by the present invention;

[0022] Figure 4 This invention provides a mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizers. Figure 3 Enlarged structural diagram at point A in the middle;

[0023] Figure 5 A schematic diagram of the overall cross-sectional structure of a mixing reaction device for the research and development of photodynamic antibacterial photosensitizer provided by the present invention;

[0024] Figure 6 This invention provides a mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizers. Figure 5 Enlarged structural diagram at point B;

[0025] Figure 7 This invention provides a schematic diagram of the material cylinder structure of a mixing reaction device for the research and development of a photodynamic antibacterial photosensitizer.

[0026] Legend:

[0027] 1. Mixing tank; 101. Feed hopper; 102. Pressure relief valve; 103. Air pressure sensor; 104. Insulation jacket; 105. Discharge pipe; 106. Temperature sensor; 107. Heating ring; 2. U-shaped plate; 201. Motor; 202. Crank; 203. Stirring rod; 204. Air inlet pipe; 205. Pneumatic rotary joint; 206. Air guide pipe; 207. Aeration hole; 3. Guide frame; 301. Material cylinder; 302. Inclined frame; 303. Perforated grinding plate; 304. Return groove; 305. Sealing plate; 306. Electric telescopic rod; 307. Synchronous pulley one; 308. Synchronous belt; 309. Connecting strip; 310. Round rod; 311. Synchronous pulley two; 312. Round hole. Detailed Implementation

[0028] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0029] Examples, such as Figure 1 - Figure 7 As shown, the present invention provides a technical solution: a mixing reaction device for the research and development of photodynamic antibacterial photosensitizer, comprising: a mixing tank 1, a stirring rod 203 rotatably connected to the opposite side of the inner wall of the mixing tank 1, a U-shaped plate 2 fixedly connected to the top of the mixing tank 1, a motor 201 fixedly connected to the top of the U-shaped plate 2, a crank 202 fixedly connected to the output end of the motor 201, the crank 202 being fixedly connected to the stirring rod 203, a connecting strip 309 rotatably connected to the outer surface of the crank 202, a guide frame 3 fixedly connected to the top of the mixing tank 1, a perforated grinding plate 303 slidably connected to the opposite side of the guide frame 3 near the top inner wall, a round rod 310 fixedly connected to the connecting strip 309 near the top of the perforated grinding plate 303, the round rod 310 being rotatably connected to the perforated grinding plate 303, a material cylinder 301 rotatably connected to the top of the guide frame 3, and a plurality of round holes 312 being opened at the bottom of the material cylinder 301.

[0030] Furthermore, such as Figure 1 - Figure 7 As shown, a second synchronous pulley 311 is fixedly connected to the outer surface of the crank 202, and a first synchronous pulley 307 is fixedly connected to the outer surface of the barrel 301. A synchronous belt 308 meshes with the outer surfaces of the first synchronous pulley 307 and the second synchronous pulley 311. By rotating the crank 202, the second synchronous pulley 311 can be driven to rotate. Then, with the cooperation of the second synchronous pulley 311, the synchronous belt 308 and the first synchronous pulley 307, the barrel 301 can be driven to rotate.

[0031] Furthermore, such as Figure 1 - Figure 7 As shown, a return groove 304 is provided on the opposite side of the guide frame 3, and an inclined frame 302 is fixedly connected to the opposite side of the guide frame 3. The inclined frame 302 facilitates the collection of powder carried out by the perforated grinding plate 303 during grinding, and the powder falls back into the guide frame 3 along the inclined surface of the inclined frame 302 through the return groove 304.

[0032] Furthermore, such as Figure 1 - Figure 7 As shown, a sealing plate 305 is slidably connected to the bottom side of the guide frame 3. An electric telescopic rod 306 is fixedly installed on the top of the mixing tank 1. One end of the electric telescopic rod 306 is fixedly connected to one side of the sealing plate 305. The electric telescopic rod 306 is extended by the controller, so that the sealing plate 305 is reinserted into the guide frame 3 to seal between the guide frame 3 and the mixing tank 1. Conversely, the seal can be released, allowing the powdered raw material to fall into the mixing tank 1.

[0033] Furthermore, such as Figure 1 - Figure 7As shown, a pneumatic rotary joint 205 is fixedly connected to one end of the stirring rod 203. Multiple air guide pipes 206 are fixedly connected in a circumferential array on the outer surface of the pneumatic rotary joint 205. Multiple aeration holes 207 are equidistantly opened on the outer surface of the air guide pipes 206. By rotating the stirring rod 203, the pneumatic rotary joint 205 and the air guide pipes 206 can be driven to rotate. With the cooperation of the rotation of the stirring rod 203 and the aeration holes 207, the raw materials are mixed and stirred. At the same time, nitrogen is delivered to the raw materials from the aeration holes 207 to produce an aeration effect.

[0034] Furthermore, such as Figure 1 - Figure 7 As shown, an air inlet pipe 204 is fixedly connected to the bottom of the mixing tank 1. The air inlet pipe 204 is rotatably connected to the pneumatic rotary joint 205. The air inlet pipe 204 is connected to the air inlet of the pneumatic rotary joint 205. The air guide pipe 206 is connected to the air outlet of the pneumatic rotary joint 205. The air supply end of the external nitrogen supply system is connected to the air inlet pipe 204 and supplies nitrogen to the air inlet pipe 204. The nitrogen is then transported to the mixing tank 1 through the pneumatic rotary joint 205, the air guide pipe 206 and the aeration hole 207 in sequence. Since the density of nitrogen is less than that of air, air can be discharged through the feed hopper 101.

[0035] Furthermore, such as Figure 1 - Figure 7 As shown, a pressure relief valve 102, a pressure sensor 103, and a temperature sensor 106 are fixedly connected to the top of the mixing tank 1. The pressure relief valve 102 is connected to the mixing tank 1. One end of the pressure sensor 103 and the temperature sensor 106 both extend into the interior of the mixing tank 1. The pressure sensor 103 detects the pressure in the mixing tank 1. When the pressure reaches a certain value, the signal can be transmitted to the controller, which then controls the pressure relief valve 102 to open, allowing some of the nitrogen in the mixing tank 1 to be released. A nitrogen recovery system can be connected to the outlet of the pressure relief valve 102 to recover the nitrogen and reduce the cost of nitrogen use. The temperature sensor 106 detects the temperature in the mixing tank 1.

[0036] Furthermore, such as Figure 1 - Figure 7 As shown, an insulation sleeve 104 is fixedly connected to the outer surface of the mixing tank 1, and multiple heating rings 107 are fixedly connected at equal intervals to the inner wall of the insulation sleeve 104. The heating rings 107 are heated by the controller, so that the heat inside the insulation sleeve 104 is transferred to the mixing tank 1, providing a suitable temperature for the raw material mixing reaction.

[0037] Furthermore, such as Figure 1 - Figure 7As shown, a feed hopper 101 is fixedly connected to the top of the mixing tank 1, and the feed hopper 101 is connected to the mixing tank 1. A discharge pipe 105 is fixedly connected to the bottom of the mixing tank 1, and the discharge pipe 105 is connected to the mixing tank 1. A valve is fixedly connected to the outer surface of the discharge pipe 105. The feed hopper 101 facilitates the addition of raw materials to the mixing tank 1. By opening the valve, the mixture in the mixing tank 1 can be discharged.

[0038] Working Principle: In use, the crystalline solid raw material for photodynamic antibacterial photosensitizer research and development is added to the barrel 301. The controller then starts the motor 201, causing its output shaft to rotate the crank 202 and connecting bar 309. This causes the round rod 310 to move the perforated grinding plate 303 back and forth. Simultaneously, the rotation of the crank 202 drives the second synchronous pulley 311 to rotate. Then, with the cooperation of the second synchronous pulley 311, the synchronous belt 308, and the first synchronous pulley 307, the barrel 301 rotates. This allows the crystalline solid raw material inside the barrel 301 to contact the perforated grinding plate 303 through the round hole 312. The combination of the reciprocating movement of the perforated grinding plate 303 and the rotation of the barrel 301 crushes and grinds the crystalline solid raw material into powder. The material falls downwards through the perforated grinding plate 303, and then the electric telescopic rod 306 retracts under the control of the controller, allowing the sealing plate 305 to move out from inside the guide frame 3. This allows the powdered raw material to be added into the mixing tank 1, facilitating the grinding of the crystalline solid raw material and its subsequent mixing and reaction with the liquid and powdered raw materials, thereby increasing the fusion speed and improving the efficiency of photodynamic antibacterial photosensitizer production. After adding an appropriate amount, the electric telescopic rod 306 extends under the control of the controller, allowing the sealing plate 305 to re-insert into the guide frame 3, sealing the guide frame 3 and the mixing tank 1. Then, the liquid and powdered raw materials used for the research and development of photodynamic antibacterial photosensitizer are added into the mixing tank 1 through the feed hopper 101, simultaneously... Rotation of crank 202 drives stirring rod 203 to mix various raw materials. Simultaneously, nitrogen is supplied through an external nitrogen delivery system connected to inlet pipe 204. The nitrogen then passes through pneumatic rotary joint 205, air guide pipe 206, and aeration hole 207 into mixing tank 1. Since nitrogen is less dense than air, air can be discharged through feed hopper 101. After a certain period, feed hopper 101 is sealed. Pressure sensor 103 monitors the pressure in mixing tank 1. When the pressure reaches a limit, a signal is transmitted to controller, which opens pressure relief valve 102 to release some nitrogen from mixing tank 1. A nitrogen recovery system is connected to the outlet of the pressure relief valve 102 to recover nitrogen and reduce nitrogen usage costs. Simultaneously, a controller controls the heating ring 107 to heat the mixture, transferring heat from the insulation jacket 104 to the mixing tank 1, providing a suitable temperature for the raw material mixing reaction. A temperature sensor 106 monitors the temperature in the mixing tank 1. Simultaneously, the rotation of the stirring rod 203 drives the pneumatic rotary joint 205 and the air guide pipe 206 to rotate. Through the coordinated rotation of the stirring rod 203 and the aeration holes 207, the raw materials are mixed and stirred. Nitrogen is simultaneously delivered to the raw materials through the aeration holes 207, creating an aeration effect. This ensures more thorough mixing of the raw materials, thereby improving the quality of the photodynamic antibacterial photosensitizer production.Simultaneously, the reciprocating movement of the perforated grinding plate 303 and the rotation of the feed cylinder 301 continuously crush and grind the crystalline solid raw material, facilitating its next use.

[0039] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizers, characterized in that, include: A mixing tank (1) has a stirring rod (203) rotatably connected to one side of its inner wall. A U-shaped plate (2) is fixedly connected to the top of the mixing tank (1). A motor (201) is fixedly connected to the top of the U-shaped plate (2). A crank (202) is fixedly connected to the output end of the motor (201). The crank (202) is fixedly connected to the stirring rod (203). A connecting strip (309) is rotatably connected to the outer surface of the crank (202). (1) is fixedly connected to the top of a guide frame (3), and a perforated grinding plate (303) is slidably connected to the opposite side of the guide frame (3) near the top inner wall. A round rod (310) is fixedly connected to the top of the connecting strip (309) near the perforated grinding plate (303). The round rod (310) is rotatably connected to the perforated grinding plate (303). A material cylinder (301) is rotatably connected to the top of the guide frame (3), and multiple round holes (312) are opened at the bottom of the material cylinder (301).

2. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 1, characterized in that: The outer surface of the crank (202) is fixedly connected to a second synchronous pulley (311), the outer surface of the barrel (301) is fixedly connected to a first synchronous pulley (307), and the outer surfaces of the first synchronous pulley (307) and the second synchronous pulley (311) are meshed with a synchronous belt (308).

3. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 1, characterized in that: The opposite side of the guide frame (3) is provided with a return groove (304), and the opposite side of the guide frame (3) is fixedly connected with an inclined frame (302).

4. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 3, characterized in that: The guide frame (3) is sealed and slidably connected to a sealing plate (305) on one side near the bottom. An electric telescopic rod (306) is fixedly installed on the top of the mixing tank (1), and one end of the electric telescopic rod (306) is fixedly connected to one side of the sealing plate (305).

5. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 1, characterized in that: One end of the stirring rod (203) is fixedly connected to a pneumatic rotary joint (205). The outer surface of the pneumatic rotary joint (205) is fixedly connected with multiple air guide pipes (206) in a circumferential array. The outer surface of the air guide pipes (206) is provided with multiple aeration holes (207) at equal intervals.

6. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 5, characterized in that: The bottom of the mixing tank (1) is fixedly connected to an air inlet pipe (204), which is rotatably connected to a pneumatic rotary joint (205). The air inlet pipe (204) is connected to the air inlet of the pneumatic rotary joint (205), and the air guide pipe (206) is connected to the air outlet of the pneumatic rotary joint (205).

7. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 1, characterized in that: The top of the mixing tank (1) is fixedly connected to a pressure relief valve (102), a pressure sensor (103) and a temperature sensor (106). The pressure relief valve (102) is connected to the mixing tank (1), and one end of the pressure sensor (103) and the temperature sensor (106) extends into the interior of the mixing tank (1).

8. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 7, characterized in that: The outer surface of the mixing tank (1) is fixedly connected to an insulation sleeve (104), and the inner wall of the insulation sleeve (104) is fixedly connected to multiple heating rings (107) at equal intervals.

9. The mixing reaction apparatus for the research and development of photodynamic antibacterial photosensitizer according to claim 8, characterized in that: The top of the mixing tank (1) is fixedly connected to a feed hopper (101), which is connected to the mixing tank (1). The bottom of the mixing tank (1) is fixedly connected to a discharge pipe (105), which is connected to the mixing tank (1). A valve is fixedly connected to the outer surface of the discharge pipe (105).

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