Plasma pollutant treatment device for syphilis patient
By employing multiple treatment methods, including electromagnetic separation, regeneration and recycling, and synergistic inactivation, the problems of magnetic nanoparticle accumulation and low separation efficiency in syphilis patient plasma contaminant treatment devices have been solved, achieving efficient and safe plasma contaminant treatment.
Patent Information
- Application Number
- CN202511808854.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-03
- Publication Date
- 2026-01-23
AI Technical Summary
Existing magnetic adsorption separation devices suffer from channel blockage and low separation efficiency when processing contaminants in the plasma of syphilis patients, due to the accumulation of magnetic nanoparticles and Treponema pallidum complexes, making it difficult to meet clinical safety requirements.
An electromagnetic separation mechanism is used for gradient magnetic field separation, combined with an ultrasonic oscillator to prevent accumulation, and a temperature control sleeve to avoid plasma protein denaturation; the regeneration and recovery mechanism recovers magnetic nanoparticles through eluent and regeneration liquid, the synergistic inactivation mechanism uses plasma to destroy the helical structure, and the multiple adsorption mechanism removes antibodies and inflammatory factors through an adsorption column.
It achieves efficient separation and complete inactivation of Treponema pallidum, ensuring separation efficiency and the integrity of plasma active components, simplifying the operation process, and reducing consumable costs and environmental pollution.
Smart Images
Figure CN121377431A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The application relates to the technical field of pollution treatment equipment, in particular to a syphilis patient plasma pollution treatment device. BACKGROUND
[0002] In clinical blood transfusion safety and blood product production, efficient treatment of syphilis patient plasma pollution is a key problem to be solved. Treponema pallidum, as the core pollutant in the plasma, is small in size and easy to adhere to the surface of plasma protein, so that conventional treatment technology cannot achieve complete removal.
[0003] The magnetic adsorption separation technology has become one of the mainstream technologies for treating syphilis patient plasma pollution due to the advantages of convenient operation, small damage to plasma components and high treatment efficiency, and is widely used in clinical pretreatment and blood product purification. However, the existing magnetic adsorption separation device generally adopts a uniform magnetic field design. In the actual treatment process, the complex formed by the magnetic nanoparticles and the treponema pallidum is easy to accumulate in the separation channel, which not only may cause channel blockage and affect process continuity, but also may cause part of the complex to be unable to be effectively captured, finally leading to low separation efficiency and excessive residual pollution, which is difficult to meet the clinical safety requirements. Therefore, the technical personnel in the field propose a syphilis patient plasma pollution treatment device to solve the above technical problems. SUMMARY
[0004] In view of the deficiencies of the prior art, the application provides a syphilis patient plasma pollution treatment device, which solves the problem that part of the complex cannot be effectively captured due to the use of a uniform magnetic field in the existing magnetic separation device.
[0005] To achieve the above purpose, the application is implemented by the following technical scheme: a syphilis patient plasma pollution treatment device, comprising, a bottom plate, the top middle part of the bottom plate is fixedly connected with a mounting frame; an electromagnetic separation mechanism, which is arranged at the top middle part of the mounting frame and is used for separating and treating syphilis patient plasma pollution by using electromagnetic treatment; a regeneration and recovery mechanism, which is arranged at one side of the top of the mounting frame and is used for regenerating and recovering the magnetic nanoparticles after the treatment of the electromagnetic separation mechanism; a synergistic inactivation mechanism, which is arranged at one side of the top of the bottom plate and is used for multiple inactivation treatment of the spiral pollution in the plasma pollution after the treatment of the electromagnetic separation mechanism; a multiple adsorption mechanism, which is arranged at the other side of the top of the mounting frame and is used for multiple adsorption treatment of the high-concentration antibodies and inflammatory factors remaining in the plasma after the treatment of the synergistic inactivation mechanism.
[0006] Preferably, the electromagnetic separation mechanism comprises a premixing box, the middle of the top end of the mounting frame is provided with the premixing box, the middle of the top of the front side of the premixing box is provided with a temperature sensor for monitoring the internal temperature thereof, the middle of the mounting frame is provided with a premixer for pretreatment mixing of the liquid in the premixing box, the middle of the top end of the premixing box is provided with an input pipe, and the middle of the rear end of the top end of the mounting frame is provided with a peristaltic pump.
[0007] Preferably, the electromagnetic separation mechanism further comprises a quartz separation column, the middle of the bottom end of the mounting frame is provided with the quartz separation column, the inside of the quartz separation column is communicated with the inside of the premixing box through a connecting pipe, the top of the inner wall of the bottom end of the mounting frame is provided with an electromagnetic control valve one for controlling the flow state of the fluid in the premixing box and the quartz separation column, and the outer wall of the quartz separation column is provided with a temperature control sleeve.
[0008] Preferably, the electromagnetic separation mechanism further comprises a cavity, the inside of the quartz separation column is provided with the cavity, a plurality of annular rod holders are equidistantly arranged in the inside of the cavity, an electromagnetic coil is arranged on each annular rod holder, the axial magnetic field generated by the electromagnetic coils increases from the inlet to the outlet, the inner wall of the quartz separation column is provided with a polished wall, the middle lower part of the outer wall of the quartz separation column is provided with an intermittently started ultrasonic oscillator, the middle front part of the front end of the bottom plate is provided with a temporary storage box, the inside of the temporary storage box is communicated with the bottom of the quartz separation column, and the bottom of the quartz separation column is provided with an electromagnetic control valve two.
[0009] Preferably, the regeneration and recovery mechanism comprises a three-way electromagnetic valve one, the middle of the top end of the mounting frame is provided with the three-way electromagnetic valve one, an eluent cylinder and a regeneration liquid cylinder are respectively arranged on one side of the middle of the top end of the mounting frame, the bottom of one side of the eluent cylinder and the regeneration liquid cylinder is respectively communicated with two input ports of the three-way electromagnetic valve one through output pipes at corresponding positions, a conveying pump one is arranged on one side of the middle of the top end of the inner wall of the mounting frame, the output end of the three-way electromagnetic valve one is communicated with the liquid inlet of the conveying pump one through a connecting pipe, and the liquid outlet of the conveying pump one is communicated with the inside of the quartz separation column through a connecting pipe.
[0010] Preferably, the regeneration and recovery mechanism further comprises a centrifugal cylinder, the centrifugal cylinder is arranged on one side of the middle front part of the top end of the bottom plate, one side of the centrifugal cylinder is communicated with one of the output ports of the electromagnetic control valve two through a connecting pipe, a waste collection cylinder is arranged on one side of the middle rear part of the top end of the bottom plate, and the waste collection cylinder is communicated with the inside of the centrifugal cylinder through a connecting pipe.
[0011] Preferably, the synergic inactivation mechanism comprises a serpentine quartz discharge tube, the top end of the bottom plate is provided with the serpentine quartz discharge tube on one side, one end of the serpentine quartz discharge tube is communicated with the inside of the temporary storage box, the middle and lower part of one side of the mounting frame is provided with a plasma generator, the front end of the serpentine quartz discharge tube is provided with an argon gas inlet pipe on one side, the inside of the argon gas inlet pipe is communicated with the inside of the serpentine quartz discharge tube, and a matching connector is arranged on the end of the argon gas inlet pipe away from the serpentine quartz discharge tube.
[0012] Preferably, the synergic inactivation mechanism further comprises a supporting seat, the middle and rear part of one side of the top end of the mounting frame is fixedly connected with the supporting seat, and the supporting seat is provided with a second conveying pump.
[0013] Preferably, the multiple adsorption mechanism comprises an adsorption box, the middle and front part of the top end of the mounting frame is provided with the adsorption box on one side, and the liquid outlet of the second conveying pump is communicated with the inside of the adsorption box through a connecting pipe.
[0014] Preferably, the multiple adsorption mechanism further comprises a discharge pipe, the middle part of the bottom end of the rear side of the adsorption box is provided with the discharge pipe, the middle and upper part of the inner side of the adsorption box is provided with an upper adsorption column, and the middle and lower part of the inner side of the adsorption box is provided with a lower adsorption column.
[0015] Working principle: in the treatment of syphilis patients in the process of plasma pollutants produced in the processing, first electromagnetic separation mechanism starts, plasma pollutants through the installation of peristaltic pump and pre-mixing box on the input pipe into its pre-mixing box inside, then enter the pre-mixing box inside the plasma pollutants and its internal magnetic nanoparticles suspension mixing by volume ratio, while through the installation of pre-mixer auxiliary mixing box in the fluid mixing treatment, and in the pre-mixing box inside the plasma pollutants and magnetic nanoparticles suspension mixing process, through the temperature sensor on the pre-mixing box inside the reaction temperature real-time monitoring, at this time the magnetic nanoparticles and plasma pollutants in the antibody and spirochaeta specific binding, and also through the electrostatic effect enhances its binding stability, form magnetic nanoparticles-syphilis spirochaeta complex, after the staff through the control equipment will electromagnetic control valve one is opened, so that the pre-mixing after the magnetic nanoparticles-syphilis spirochaeta complex through the connecting pipe into the quartz separation column, along with its complex into the quartz separation column, cavity in the annular rod frame on the electromagnetic coil power and produce axial gradient magnetic field, under the action of axial gradient magnetic field, magnetic nanoparticles-syphilis spirochaeta complex by magnetic field force gradually increases, from the plasma separation and adsorbed to the polished wall in the quartz separation column, then the uncombined plasma components such as albumin, blood coagulation factor along the quartz separation column inside flow channel into the temporary storage box, in this process, the quartz separation column bottom ultrasonic oscillator intermittent work, so as to prevent the complex accumulation clog the quartz separation column bottom channel, while the quartz separation column on the temperature control sleeve on its inside temperature control, avoid magnetic field heating caused by plasma protein denaturation, etc.Then the regeneration and recovery mechanism starts, after the electromagnetic separation mechanism separates the plasma contaminants, the staff disconnects the electromagnetic coil in the quartz separation column through the remote control device, after the electromagnetic coil is disconnected, the magnetic field in the quartz separation column disappears, then the three-way electromagnetic valve one conducts the delivery flow channel of the eluent cylinder, then the delivery pump one pumps the eluent in the eluent cylinder, the eluent in the eluent cylinder enters the quartz separation column through the output pipe, at this time the ultrasonic oscillator on the quartz separation column is intermittently started, the magnetic nanoparticle-syphilis spiral complex in the quartz separation column is eluted under the ultrasonic assistance of the ultrasonic oscillator, then the electromagnetic control valve two connects the quartz separation column and the centrifuge cylinder, so that a small amount of magnetic nanoparticle complex enters the centrifuge cylinder for centrifugal treatment, then the medical waste after centrifugal separation in the centrifuge cylinder enters the waste collection cylinder through the connecting pipe for collection and treatment, then the three-way electromagnetic valve one conducts the delivery flow channel of the regeneration liquid cylinder, then the delivery pump one pumps the regeneration liquid in the regeneration liquid cylinder, the regeneration liquid in the regeneration liquid cylinder enters the quartz separation column through the output pipe, when the eluted magnetic nanoparticles and the regeneration liquid in the quartz separation column are mixed again, the magnetic nanoparticles are regenerated under the assistance of the regeneration liquid, and after the regeneration is completed, the regeneration liquid is pumped out and injected into other auxiliary liquid, so as to form new magnetic nanoparticle suspension which can be used again for subsequent magnetic separation, so as to complete the regeneration and recovery of the magnetic nanoparticles; then the inactivation mechanism starts, first the staff connects the matching connector on the argon inlet pipe with the exhaust pipe of the argon generator, then after connecting, the argon is discharged into the serpentine quartz discharge tube through the argon inlet pipe, the air remaining in the tube is discharged through the argon discharge, so as to provide a stable atmosphere for plasma generation, then the delivery pump two on the support seat starts, the delivery pump two pumps the serpentine quartz discharge tube through the connecting pipe, so that the plasma after magnetic separation in the temporary storage box enters the serpentine quartz discharge tube, at this time the plasma generator starts, the plasma generates a large amount of active oxygen and nitrogen free radicals in the argon atmosphere in the serpentine quartz discharge tube, which destroys the cell wall lipid components and nucleic acid structure of syphilis spiral, forms ultrasonic cavitation effect, and forms micro bubbles in the serpentine quartz discharge tube, the shock wave and local high temperature released when the bubbles burst further crush the spiral structure, through the synergistic effect of the two, the plasma is inactivated efficiently, so as to complete the multiple synergistic inactivation of the plasma.After the multiple adsorption mechanism is started, the plasma treated by the synergistic inactivation mechanism is pumped into the adsorption box by the delivery pump two, the plasma entering the adsorption box is first filtered by the pretreatment layer at the top of the upper adsorption column to remove the impurities remaining in the pretreatment layer, then the antibodies in the plasma are separated from the plasma after the impurities are separated, the plasma from which the antibodies are removed flows into the lower adsorption column at the lower part of the adsorption box, the complex filler in the lower adsorption column removes the inflammatory factors in the plasma by hydrophobic effect, and finally the plasma treated by multiple treatments is discharged through the discharge pipe, so that the multiple adsorption treatment of the plasma pollutants of the syphilis patient is completed.
[0016] The application provides a syphilis patient plasma pollutant treatment device. 1、The application increases and sets the electromagnetic separation mechanism, which can fully mix the plasma pollutants and magnetic nanoparticles in cooperation with the premixing box and the premixer, provides stable conditions for the specific binding of the magnetic nanoparticles and the treponema pallidum through the real-time temperature control of the temperature sensor, ensures the efficient formation of the complex, the axial gradient magnetic field in the quartz separation column gradually increases from the inlet to the outlet, the polished inner wall reduces adsorption residues, the complex can be completely separated, the ultrasonic oscillator works intermittently to prevent accumulation and blockage, and the temperature control sleeve avoids plasma protein denaturation, so that the separation efficiency is guaranteed and the plasma activity is protected.
[0017] 2、The application increases and sets the regeneration and recovery mechanism, which can not only flexibly switch the delivery of the eluent and the regeneration liquid through the three-way electromagnetic valve one, accurately supply the liquid through the delivery pump one, and assist in elution through the ultrasonic oscillator, but also separate the complex and the particles through the centrifugal processing of the centrifugal cylinder, the regeneration liquid can restore the activity of the particles to realize repeated use, in addition, the medical waste is collected in a standard manner through the waste collection cylinder, so that the cost of consumables is reduced, environmental pollution is avoided, and the operation process is simplified.
[0018] 3、The application increases and sets the synergistic inactivation mechanism, which can first introduce argon into the air in the serpentine quartz discharge tube through the argon inlet pipe to provide a stable atmosphere for the generation of plasma and avoid the interference of impurities on the inactivation effect, secondly, the active substances generated by the plasma generator and the ultrasonic cavitation effect form a synergistic effect to efficiently destroy the structure of the treponema pallidum and achieve complete inactivation, the serpentine structure prolongs the residence time of the plasma, the delivery pump two accurately controls the flow rate, the inactivation is ensured to be sufficient, and the whole process is low-temperature processing, which effectively retains the active ingredients such as albumin and coagulation factors in the plasma.
[0019] 4、The application can filter the residual impurities in the blood plasma by the pretreatment layer of the upper adsorption column, and the internal filler can specifically bind and remove the syphilis antibodies in the blood plasma, so as to avoid the subsequent immune response caused by the antibodies, and then the complex filler of the lower adsorption column can efficiently capture the inflammatory factors through the hydrophobic effect and hydrogen bond, so that the antibodies and the inflammatory factors are synchronously removed, and the safety of the blood plasma is greatly improved after the step-by-step adsorption, so as to provide protection for subsequent clinical use or product production. BRIEF DESCRIPTION OF DRAWINGS
[0020] Figure 1 It is a front side structure schematic diagram of the application; Figure 2 It is a rear side structure schematic diagram of the application; Figure 3 It is a premixing box local structure schematic diagram of the application; Figure 4 It is an eluent cylinder local structure schematic diagram of the application; Figure 5 It is a quartz separation column local structure schematic diagram of the application; Figure 6 It is a quartz separation column internal structure cross-sectional view schematic diagram of the application; Figure 7 It is an adsorption box internal structure cross-sectional view schematic diagram of the application; Figure 8 It is a serpentine quartz discharge tube local structure schematic diagram of the application.
[0021] 1, bottom plate; 2, centrifugal cylinder; 3, mounting frame; 4, waste collection cylinder; 5, eluent cylinder; 6, three-way electromagnetic valve one; 7, regeneration liquid cylinder; 8, conveying pump one; 9, premixing box; 10, temperature sensor; 11, input pipe; 12, premixer; 13, electromagnetic control valve one; 14, conveying pump two; 15, adsorption box; 16, serpentine quartz discharge tube; 17, temperature control sleeve; 18, plasma generator; 19, argon gas access pipe; 20, ultrasonic oscillator; 21, temporary storage box; 22, electromagnetic control valve two; 23, peristaltic pump; 24, quartz separation column; 25, support seat; 26, discharge pipe; 27, output pipe; 28, cavity; 29, polished wall; 30, annular rod frame; 31, electromagnetic coil; 32, upper adsorption column; 33, lower adsorption column; 34, matching connector. DETAILED DESCRIPTION
[0022] Clearly, the described embodiments are merely a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those of ordinary skill in the art without creative effort should belong to the protection scope of the present application.
[0023] Please refer to the accompanying drawings Figure 1 - the accompanying drawings Figure 2 The embodiment of the present application provides a syphilis patient plasma contaminant treatment device, which comprises a bottom plate 1, and a mounting rack 3 is fixedly connected to the middle top of the bottom plate 1. Please refer to the accompanying drawings Figure 3 and the accompanying drawings Figure 5 - the accompanying drawings Figure 6 An electromagnetic separation mechanism is arranged at the middle top of the mounting rack 3, and is used for separating and treating the syphilis patient plasma contaminant by using an electromagnetic treatment method. The electromagnetic separation mechanism comprises a premixing box 9, the middle top of the mounting rack 3 is provided with the premixing box 9, a temperature sensor 10 for monitoring the internal temperature of the premixing box 9 is arranged at the middle upper part of the front side of the premixing box 9, a premixer 12 for pre-treating and mixing the liquid in the premixing box 9 is arranged at the middle part of the mounting rack 3, an input pipe 11 is arranged at the middle top of the mounting rack 3, and a peristaltic pump 23 is arranged at the middle rear part of the mounting rack 3.
[0024] When the electromagnetic separation mechanism is started, the plasma contaminant is pumped into the premixing box 9 through the peristaltic pump 23 on the mounting rack 3 and the input pipe 11 on the premixing box 9, then the plasma contaminant in the premixing box 9 is mixed with the magnetic nanoparticle suspension in the premixing box 9 according to the volume ratio, and the fluid in the premixing box 9 is mixed and treated by the premixer 12 on the mounting rack 3.
[0025] The electromagnetic separation mechanism further comprises a quartz separation column 24, the middle bottom of the mounting rack 3 is provided with the quartz separation column 24, the inside of the quartz separation column 24 is communicated with the inside of the premixing box 9 through a connecting pipe, an electromagnetic control valve one 13 for controlling the fluid flow state in the premixing box 9 and the quartz separation column 24 is arranged at the top of the inner wall of the bottom end of the mounting rack 3, and a temperature control sleeve 17 is arranged on the outer wall of the quartz separation column 24.
[0026] In the process of mixing the plasma contaminant and the magnetic nanoparticle suspension in the premixing box 9, the reaction temperature in the premixing box 9 is monitored in real time by the temperature sensor 10, at this time, the magnetic nanoparticle is specifically combined with the antibody and the spirochete in the plasma contaminant, and the stability of the combination is enhanced by electrostatic action, and a magnetic nanoparticle-syphilis spirochete complex is formed.
[0027] The electromagnetic separation mechanism further comprises a cavity 28, the interior of the quartz separation column 24 is provided with the cavity 28, a plurality of annular rod holders 30 are equidistantly arranged in the interior of the cavity 28, the annular rod holders 30 are all provided with electromagnetic coils 31, the axial magnetic field generated by the electromagnetic coils 31 increases from the inlet to the outlet, the inner wall of the quartz separation column 24 is all provided with a polished wall 29, the lower part of the outer wall of the quartz separation column 24 is provided with an intermittently started ultrasonic oscillator 20, the front end of the bottom plate 1 is provided with a temporary storage box 21, the interior of the temporary storage box 21 is communicated with the bottom of the quartz separation column 24, and the bottom of the quartz separation column 24 is provided with an electromagnetic control valve two 22.
[0028] Then the staff opens the electromagnetic control valve one 13 through the control device, so that the magnetic nanoparticle-syphilis spirochete compound after the premixing treatment enters into the quartz separation column 24 through the connecting pipe, along with the compound entering into the quartz separation column 24, the electromagnetic coils 31 on the annular rod holders 30 in the cavity 28 are electrified and generate an axial gradient magnetic field, under the action of the axial gradient magnetic field, the magnetic nanoparticle-syphilis spirochete compound is gradually separated from the plasma and adsorbed on the polished wall 29 in the quartz separation column 24 under the magnetic field force gradually increasing.
[0029] Then the uncombined plasma components such as albumin and blood coagulation factors enter into the temporary storage box 21 along the internal flow channel of the quartz separation column 24, in this process, the ultrasonic oscillator 20 at the bottom of the quartz separation column 24 works intermittently, so as to prevent the compound from accumulating and clogging the channel at the bottom of the quartz separation column 24, at the same time, the temperature control sleeve 17 on the quartz separation column 24 controls the temperature in the interior, avoids the problems such as plasma protein denaturation caused by magnetic field heating, so as to complete the electromagnetic separation treatment of the plasma pollutants.
[0030] Please refer to the accompanying drawings Figure 4 The regeneration and recovery mechanism is arranged on one side of the top of the mounting frame 3, and is used for regenerating and recovering the magnetic nanoparticles after the treatment of the electromagnetic separation mechanism; The regeneration and recovery mechanism comprises a three-way electromagnetic valve one 6, the three-way electromagnetic valve one 6 is arranged on one side of the top of the mounting frame 3, the elution liquid cylinder 5 and the regeneration liquid cylinder 7 are arranged on one side of the top of the mounting frame 3, respectively, the bottom of one side of the elution liquid cylinder 5 and the regeneration liquid cylinder 7 is communicated with two input ports of the three-way electromagnetic valve one 6 through the output pipes 27 at the corresponding positions, the top of one side of the inner wall of the mounting frame 3 is provided with a delivery pump one 8, the output end of the three-way electromagnetic valve one 6 is communicated with the liquid inlet of the delivery pump one 8 through the connecting pipe, and the liquid outlet of the delivery pump one 8 is communicated with the interior of the quartz separation column 24 through the connecting pipe.
[0031] When the regeneration and recovery mechanism is started, after the electromagnetic separation mechanism separates the plasma contaminants, the staff member uses the remote control device to power off the electromagnetic coil 31 in the quartz separation column 24. After the electromagnetic coil 31 is powered off, the magnetic field in the quartz separation column 24 disappears. Then, the three-way electromagnetic valve 1 6 is turned on to guide the transport flow channel of the eluent cylinder 5. Then, the transport pump 1 8 pumps the eluent in the eluent cylinder 5. The eluent in the eluent cylinder 5 enters the quartz separation column 24 through the output pipe 27.
[0032] At this time, the ultrasonic oscillator 20 on the quartz separation column 24 is intermittently started. The magnetic nanoparticle-syphilis spiral complex in the quartz separation column 24 is eluted under the ultrasonic assistance of the ultrasonic oscillator 20. Then, the electromagnetic control valve 2 2 is turned on to guide the quartz separation column 24 and the centrifugal cylinder 2, so that a small amount of the magnetic nanoparticle complex enters the centrifugal cylinder 2 for centrifugal treatment. After the medical waste is centrifugally separated in the centrifugal cylinder 2, it enters the waste collection cylinder 4 through the connecting pipe for collection and treatment.
[0033] The regeneration and recovery mechanism also includes the centrifugal cylinder 2. The centrifugal cylinder 2 is arranged on the top end of the front side of the bottom plate 1. One side of the centrifugal cylinder 2 is in communication with one of the output ports of the electromagnetic control valve 2 2 through the connecting pipe. The waste collection cylinder 4 is arranged on the top end of the rear side of the bottom plate 1. The waste collection cylinder 4 is in communication with the inside of the centrifugal cylinder 2 through the connecting pipe.
[0034] Then, the three-way electromagnetic valve 1 6 is turned on to guide the transport flow channel of the recovery liquid cylinder 7. Then, the transport pump 1 8 pumps the regeneration liquid in the recovery liquid cylinder 7. The regeneration liquid in the recovery liquid cylinder 7 enters the quartz separation column 24 through the output pipe 27. When the eluted magnetic nanoparticles and the regeneration liquid are mixed again in the quartz separation column 24, the magnetic nanoparticles are renatured with the assistance of the regeneration liquid. After the renaturation is completed, the regeneration liquid is pumped out and injected into other auxiliary liquid, thereby forming a new magnetic nanoparticle suspension that can be used for subsequent magnetic separation. In this way, the regeneration and recovery of the magnetic nanoparticles are completed.
[0035] Please refer to the accompanying drawings Figure 8 The synergistic inactivation mechanism is arranged on the top side of the bottom plate 1 and is used for multiple inactivation treatment of the spiral contaminants in the plasma contaminants treated by the electromagnetic separation mechanism. The synergic inactivation mechanism comprises a serpentine quartz discharge tube 16, which is arranged on the top end of the base plate 1, and one end of the serpentine quartz discharge tube 16 is in communication with the inside of the temporary storage box 21, and the middle and lower part of one side of the mounting frame 3 is provided with a plasma generator 18, and the front end of the serpentine quartz discharge tube 16 is provided with an argon gas inlet pipe 19, and the inside of the argon gas inlet pipe 19 is in communication with the inside of the serpentine quartz discharge tube 16, and the end of the argon gas inlet pipe 19 away from the serpentine quartz discharge tube 16 is provided with a matching joint 34.
[0036] When the synergic inactivation mechanism is started, first, the staff connects the matching joint 34 on the argon gas inlet pipe 19 with the exhaust pipe of the argon gas generator, and then after the connection is completed, the argon gas is discharged into the serpentine quartz discharge tube 16 through the argon gas inlet pipe 19, and the air remaining in the tube is discharged through the discharge of the argon gas in the serpentine quartz discharge tube 16, thereby providing a stable atmosphere for the generation of plasma.
[0037] The synergic inactivation mechanism further comprises a support seat 25, and the middle and rear part of the top end of the mounting frame 3 is fixedly connected with the support seat 25, and the support seat 25 is provided with a delivery pump two 14, and the liquid inlet of the delivery pump two 14 is in communication with the inside of the serpentine quartz discharge tube 16 through a connecting pipe.
[0038] Then the delivery pump two 14 on the support seat 25 is started, and the delivery pump two 14 drives the serpentine quartz discharge tube 16 through the connecting pipe, so that the plasma in the temporary storage box 21 after the magnetic separation enters the serpentine quartz discharge tube 16, at this time the plasma generator 18 is started, and a large amount of active oxygen and nitrogen free radicals are generated in the argon atmosphere in the serpentine quartz discharge tube 16, which destroys the cell wall lipid component and nucleic acid structure of the syphilis spirochetes, and forms ultrasonic cavitation effect, and forms micro-bubbles in the inside of the serpentine quartz discharge tube 16, and the impact wave and local high temperature released when the bubble breaks, further crushes the spirochete structure, and through the synergistic effect of the two, realizes efficient synergic inactivation, so as to complete the multiple synergic inactivation treatment of the plasma.
[0039] Please refer to the accompanying drawings Figure 7 The multiple adsorption mechanism is arranged on the other side of the top of the mounting frame 3, and is used for multiple adsorption treatment of the high-concentration antibodies and inflammatory factors remaining in the plasma after the treatment of the synergic inactivation mechanism.
[0040] The multiple adsorption mechanism comprises an adsorption box 15, which is arranged on the middle and front part of the top end of the mounting frame 3, and the liquid outlet of the delivery pump two 14 is in communication with the inside of the adsorption box 15 through a connecting pipe.
[0041] When the multiple adsorption mechanism is started, the plasma treated by the synergistic inactivation mechanism is pumped into the adsorption box 15 by the delivery pump 2, and the plasma entering the adsorption box 15 is first filtered by the pretreatment layer at the top of the upper adsorption column 32 to remove the impurities remaining therein, and then the antibodies in the plasma are separated from the plasma after the impurities are separated.
[0042] The multiple adsorption mechanism further comprises a discharge pipe 26, the discharge pipe 26 is arranged in the middle of the rear bottom end of the adsorption box 15, the upper adsorption column 32 is arranged in the middle upper side of the inner side of the adsorption box 15, and the lower adsorption column 33 is arranged in the middle lower side of the inner side of the adsorption box 15.
[0043] The pretreatment layer at the top of the upper adsorption column 32 is provided with a 5mm thick quartz sand filter layer to filter the micro impurities in the plasma and avoid plugging of the filler, and the filler of the upper adsorption column 32 is protein A-sepharose gel, which fixes the protein A on the sepharose gel by covalent bond and specifically binds the Fc segment of syphilis antibody IgG.
[0044] The lower adsorption column 33 is consistent with the filler specification of the upper column body to realize modular interchange, and the lower adsorption column 33 is a porous carbon nanotube or polyethylene glycol composite adsorption material, which, after high-temperature activation, adsorbs inflammatory factors through hydrophobic interaction, hydrogen bonding and π-π stacking effect.
[0045] The plasma from which the antibodies are removed flows into the lower adsorption column 33 at the lower part of the adsorption box 15, the composite filler in the lower adsorption column 33 removes the inflammatory factors in the plasma through hydrophobic interaction, and finally the plasma treated by multiple processes is discharged through the discharge pipe 26 to complete the multiple adsorption treatment of the plasma pollutants of syphilis patients.
[0046] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.
Claims
1. A syphilis patient blood plasma contaminant treatment device, characterized by, The utility model relates to a blood plasma purification device, which comprises a bottom plate (1), a mounting rack (3) fixedly connected to the middle of the top end of the bottom plate (1), an electromagnetic separation mechanism arranged at the middle of the top end of the mounting rack (3) and used for separating and treating the blood plasma pollutants of syphilis patients by means of electromagnetic treatment, a regeneration and recovery mechanism arranged at one side of the top of the mounting rack (3) and used for regenerating and recovering the magnetic nanoparticles treated by the electromagnetic separation mechanism, a synergistic inactivation mechanism arranged at one side of the top of the bottom plate (1) and used for multiple inactivation treatment of the spirochete pollutants in the blood plasma pollutants treated by the electromagnetic separation mechanism, and a multiple adsorption mechanism arranged at the other side of the top of the mounting rack (3) and used for multiple adsorption treatment of the high-concentration antibodies and inflammatory factors remaining in the blood plasma treated by the synergistic inactivation mechanism. The electromagnetic separation mechanism comprises a premixing box (9), the middle of the top end of the mounting rack (3) is provided with the premixing box (9), the middle of the upper part of the front side of the premixing box (9) is provided with a temperature sensor (10) used for monitoring the internal temperature, the middle of the mounting rack (3) is provided with a premixer (12) for mixing the liquid in the premixing box (9), the middle of the top end of the premixing box (9) is provided with an input pipe (11), and the middle of the rear part of the top end of the mounting rack (3) is provided with a peristaltic pump (23). The electromagnetic separation mechanism further comprises a quartz separation column (24), the middle of the bottom end of the mounting rack (3) is provided with the quartz separation column (24), the inside of the quartz separation column (24) is communicated with the inside of the premixing box (9) through a connecting pipe, the top end of the inner wall of the bottom end of the mounting rack (3) is provided with an electromagnetic control valve (13) used for controlling the flow state of the fluid in the premixing box (9) and the quartz separation column (24), and the outer wall of the quartz separation column (24) is provided with a temperature control sleeve (17). The electromagnetic separation mechanism further comprises a cavity (28), the inside of the quartz separation column (24) is provided with the cavity (28), a plurality of annular rod holders (30) are equidistantly arranged in the cavity (28), the annular rod holders (30) are all provided with electromagnetic coils (31), the axial magnetic field generated by the electromagnetic coils (31) increases from the inlet to the outlet, the inner wall of the quartz separation column (24) is all provided with a polished wall (29), the middle lower part of the outer wall of the quartz separation column (24) is provided with an intermittently started ultrasonic oscillator (20), the middle front part of the front end of the bottom plate (1) is provided with a temporary storage box (21), the inside of the temporary storage box (21) is communicated with the bottom of the quartz separation column (24), and the bottom of the quartz separation column (24) is provided with an electromagnetic control valve (22). 2. The syphilis patient blood plasma contaminant processing device according to claim 1, characterized in that, 3. The syphilis patient blood plasma contaminant processing device according to claim 2, characterized in that, 4. The syphilis patient blood plasma contaminant processing device according to claim 3, characterized in that, 5. The syphilis patient blood plasma contaminant treatment device according to claim 1, characterized in that, The regeneration recycling mechanism includes a three-way electromagnetic valve one (6), and the middle one side of the top end of the mounting frame (3) is provided with the three-way electromagnetic valve one (6), and the middle one side of the top end of the mounting frame (3) is respectively provided with an eluent cylinder (5) and a regeneration liquid cylinder (7), and the bottom one side of the eluent cylinder (5) and the regeneration liquid cylinder (7) is respectively communicated with the two input ports of the three-way electromagnetic valve one (6) through the output pipe (27) at the corresponding position, and the top end of the inner wall of the mounting frame (3) is provided with a conveying pump one (8), and the output end of the three-way electromagnetic valve one (6) is communicated with the liquid inlet of the conveying pump one (8) through the connecting pipe, and the liquid outlet of the conveying pump one (8) is communicated with the inside of the quartz separation column (24) through the connecting pipe.
6. The syphilis patient blood plasma contaminant treatment device according to claim 5, characterized in that, The regeneration recycling mechanism also includes a centrifugal cylinder (2), and the top end of the front one side of the bottom plate (1) is provided with the centrifugal cylinder (2), and one side of the centrifugal cylinder (2) is communicated with one of the output ports of the electromagnetic control valve two (22) through the connecting pipe, and the top end of the rear one side of the bottom plate (1) is provided with a waste collection cylinder (4), and the waste collection cylinder (4) is communicated with the inside of the centrifugal cylinder (2) through the connecting pipe.
7. The syphilis patient blood plasma contaminant treatment device according to claim 1, characterized in that, The synergistic inactivation mechanism includes a serpentine quartz discharge tube (16), and the top end of the one side of the bottom plate (1) is provided with the serpentine quartz discharge tube (16), and one end of the serpentine quartz discharge tube (16) is communicated with the inside of the temporary storage box (21), and the middle lower part of the one side of the mounting frame (3) is provided with a plasma generator (18), and the front end of the one side of the serpentine quartz discharge tube (16) is provided with an argon gas access pipe (19), and the inside of the argon gas access pipe (19) is communicated with the inside of the serpentine quartz discharge tube (16), and the end of the argon gas access pipe (19) away from the serpentine quartz discharge tube (16) is provided with a matching connector (34).
8. The syphilis patient blood plasma contaminant treatment device according to claim 7, characterized in that, The synergistic inactivation mechanism also includes a support seat (25), and the middle rear part of the top end of the one side of the mounting frame (3) is fixedly connected with the support seat (25), and the support seat (25) is provided with a conveying pump two (14), and the liquid inlet of the conveying pump two (14) is communicated with the inside of the serpentine quartz discharge tube (16) through the connecting pipe.
9. The syphilis patient blood plasma contaminant treatment device according to claim 8, characterized in that, The multiple adsorption mechanism includes an adsorption box (15), and the middle front part of the top end of the one side of the mounting frame (3) is provided with the adsorption box (15), and the liquid outlet of the conveying pump two (14) is communicated with the inside of the adsorption box (15) through the connecting pipe.
10. The syphilis patient blood plasma contaminant processing device according to claim 9, characterized in that, The multiple adsorption mechanism also includes a discharge pipe (26), and the middle part of the bottom end of the rear side of the adsorption box (15) is provided with the discharge pipe (26), and the middle upper part of the inner side of the adsorption box (15) is provided with an upper adsorption column (32), and the middle lower part of the inner side of the adsorption box (15) is provided with a lower adsorption column (33).