Extraction method of chlorogenic acid with anti-glycation efficacy, chlorogenic acid and application thereof
By using a combination of EDTA-2Na and sodium alginate stabilizers, along with modified lignin and sea lettuce polysaccharide adsorbents, the problem of low chlorogenic acid extraction rate and purity was solved, achieving a highly efficient anti-glycation effect, which is suitable for preparing drugs that inhibit AGEs formation.
CN121378004BActive Publication Date: 2026-06-09YACHUN (GUANGZHOU) BIOTECHNOLOGY CO LTD +3
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YACHUN (GUANGZHOU) BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-12-24
- Publication Date
- 2026-06-09
AI Technical Summary
Technical Problem
The extraction rate and purity of chlorogenic acid in existing technologies are low, and its anti-glycation effect is poor, making it difficult to meet the application needs of the biomedical field.
Method used
Using coffee beans as raw material, the stability and purity of chlorogenic acid are improved by adding a combination of stabilizer EDTA-2Na and sodium alginate, combined with modified lignin and seaweed polysaccharide as adsorbents, and carrying out steps such as heating reflux, concentration, sedimentation and extraction.
Benefits of technology
It significantly improves the extraction rate and purity of chlorogenic acid and endows it with excellent anti-glycation effects, making it suitable for the preparation of drugs that inhibit the formation of AGEs.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN121378004B_ABST
Abstract
The present application relates to the technical field of plant extraction, and particularly relates to an extraction method of chlorogenic acid with anti-saccharification effect, the chlorogenic acid and application thereof. The extraction method comprises the following steps: taking coffee beans as raw materials, crushing and sieving to obtain coffee bean powder, uniformly mixing the coffee bean powder with a stabilizer, adding water and then performing heating reflux reaction for 1-3 times, concentrating to 3-5 times of the weight of the raw materials, adding an adsorbent and stirring until flocculation appears, then standing and settling, adding an ethanol aqueous solution to the sediment for heating and stirring reaction, collecting the supernatant, purifying to obtain a product, extracting and collecting an organic phase, and purifying to obtain chlorogenic acid; the stabilizer is composed of EDTA-2Na and sodium alginate; the adsorbent is composed of modified lignin and sea holly polysaccharide. The chlorogenic acid obtained by the extraction method has excellent anti-saccharification effect.
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