Inspection device for oncology department
By designing a testing device for oncology that includes a puncture tube, protective components, and linkage components, immediate cryoprotection and safe puncture are achieved, solving the problems of damage to normal tissue and delayed sample preservation caused by puncture devices, and improving operational safety and testing accuracy.
Patent Information
- Application Number
- CN202511790153.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-01
- Publication Date
- 2026-01-27
AI Technical Summary
Existing puncture devices are prone to damaging surrounding normal tissues during puncture, and the collected tissue samples are difficult to freeze and preserve immediately after removal, affecting the accuracy of test results. At the same time, the operation is less safe.
A testing device for oncology was designed, comprising a puncture tube, protective components, triggering components, and linkage components. By setting up a capsule-type cryopreservation system and a dynamic protection mechanism, it can achieve immediate cryopreservation protection and safe puncture.
It effectively reduces the risk of puncture damage, ensures immediate cryopreservation of tissue samples, improves operational safety and convenience, and enhances the accuracy of test results.
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Figure CN121400894A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of cell sampling and testing technology, specifically relating to a testing device for oncology. Background Technology
[0002] In the diagnosis and treatment of tumors, tissue biopsy is an important means of obtaining pathological information. Traditional biopsy devices mostly use a single-structure needle tube with a puncture needle core to complete the operation. The principle is to insert the needle tip into the lesion site through mechanical puncture and obtain tissue samples using negative pressure or cutting components.
[0003] For example, a tumor cell medical testing sampling device with Chinese patent application number CN202011073893.4 involves inserting a sampling needle into the human body and having the sampling port on the needle pierce the tumor tissue. An air pump is used to extract air from the inside of the sampling needle, so that the tumor tissue is drawn into the sampling needle through the sampling port. The tumor tissue exiting the sampling port is then cut off with a sampling needle. The sampling needle is then pulled out, and the tumor tissue is obtained. This sampling method is convenient, causes less harm to the patient, is easy to operate, has a simple structure, and is inexpensive. It can be used as a disposable medical device, thus avoiding the possibility of cross-infection.
[0004] While the sampling devices used in the aforementioned comparative cases can sample accurately, they still have some shortcomings in practical use: First, existing puncture devices are prone to damaging surrounding normal tissues during puncture, especially when encountering nerves, blood vessels or other sensitive tissues in the puncture path. There is a lack of effective protective mechanisms to avoid accidental injury, which increases the risk of postoperative complications for patients.
[0005] Secondly, tissue samples collected by puncture often need to be cryopreserved immediately after extraction to maintain cell viability and tissue structural integrity. Currently, the common method is to transfer the tissue sample to a cryopreservation solution after the puncture, but this process involves a time delay, which may lead to cell degeneration or death, affecting the accuracy of subsequent test results.
[0006] Furthermore, traditional puncture devices have a relatively fixed structural design, lacking flexibility and safety. For example, the puncture needle is exposed, which can easily cause medical staff to be accidentally pricked during the operation. Summary of the Invention
[0007] The purpose of this invention is to provide a testing device for oncology that can effectively reduce puncture damage, enable immediate cryopreservation of samples, and improve operational safety and convenience.
[0008] The specific technical solution adopted by this invention is as follows: A testing device for oncology includes a puncture tube, which consists of an upper needle tube and a lower needle tube; Protective components are disposed inside the puncture tube; A triggering component is disposed at the upper end of the protection component to activate the protection mechanism of the protection component; A linkage component is disposed at the lower end of the lower needle tube; The protective component includes a support part, which is slidably connected inside the lower needle tube. A pressure block is slidably connected to the upper end of the support part, and a capsule is disposed between the support part and the pressure block. The protective function is activated by puncturing the capsule in the protective component by pressing down on the trigger component.
[0009] In a preferred embodiment, the inner ring of the upper needle tube is provided with guide grooves arranged in a ring, and the upper end of the upper needle tube is connected to a lifting rod in a piston-like manner arranged in a ring. The upper end of the lifting rod is fixedly connected to a lifting block.
[0010] In a preferred embodiment, the lower end of the needle tube has through grooves arranged in a ring, and the lower end of the needle tube also has a movable groove. A pointed conical rod is slidably inserted into the movable groove, and a return spring is fixedly connected between the pointed conical rod and the movable groove.
[0011] In a preferred embodiment, the support includes a support base slidably inserted into the lower needle tube. A first compression spring is fixedly connected to the lower end of the support base. An annular cutter is fixedly connected to the bottom surface of the support base. Hollow rods are connected to the top surface of the support base in an annular pattern. A guide block is fixedly connected to the upper end of the hollow rod and is slidably connected in a guide groove. Gas channels are also formed in an annular pattern on the support base and are connected to the hollow rod.
[0012] In a preferred embodiment, the triggering component includes a puncture tube slidably inserted into the pressure block. A second compression spring is fixedly connected to the upper end of the puncture tube, and the lower end of the second compression spring is fixedly connected to the top surface of the pressure block. A venting tube is fixedly connected to the upper end of the puncture tube, and the upper end of the venting tube is piston-type inserted into the upper needle tube. Venting grooves are provided in a ring-shaped arrangement at the lower end of the venting tube, and a connector is fixedly installed at the upper end of the venting tube. The puncture tube is a hollow tube, and inlet and outlet grooves are provided in a ring-shaped arrangement on the puncture tube.
[0013] In a preferred embodiment, the linkage component includes a connecting rod, which is fixedly connected to the bottom surface of the support base, and a linkage rod is fixedly connected to the lower end of the connecting rod.
[0014] In a preferred embodiment, the linkage rod includes a sleeve rod and a telescopic rod. The sleeve rod is fixedly connected to the connecting rod, the upper end of the telescopic rod is slidably inserted into the sleeve rod, and the lower end of the telescopic rod extends through the movable groove.
[0015] In a preferred embodiment, the inner wall of the sleeve rod is provided with grooves arranged in an array, and the upper end of the telescopic rod is provided with protrusions arranged in an array to match the grooves, and the protrusions are made of rubber.
[0016] In a preferred embodiment, the pressure block and the hollow rod are slidably connected, and a rubber sleeve is provided in the through hole through which the pressure block is penetrated by the hollow rod. An air outlet groove is also provided at the upper end of the hollow rod.
[0017] In a preferred embodiment, the capsule is filled with a composite cryopreservation solution of DMSO and trehalose.
[0018] The technical effects achieved by this invention are as follows: This invention implements a dynamic protection mechanism during puncture by setting up a linkage component. When critical tissue is encountered during puncture, the operator can immediately stop pressing the lifting block. At this time, the elastic action of the first compression spring and the return spring causes the tip rod to retract into the movable groove, preventing it from forcibly continuing to extend and causing damage to critical tissue. At the same time, the hemispherical surface at the lower end of the puncture tube can still continue to advance towards the lesion site, ensuring the safety and controllability of the puncture process. This intelligent response mechanism greatly reduces the risk of damage to surrounding normal tissues and improves the overall safety of the surgery. This invention integrates a capsule-type cryopreservation system within the puncture device. Upon completion of tissue cutting, it triggers the release of a DMSO and trehalose composite cryopreservation solution, rapidly encapsulating the tissue sample and achieving in-situ rapid cryopreservation protection. This composite cryopreservation solution exhibits excellent cell protection properties, effectively maintaining cell viability and tissue structural integrity, significantly improving the accuracy and reliability of subsequent pathological analysis. This invention employs a modular assembly structure, including multiple detachable components such as an upper needle tube, a lower needle tube, a protective assembly, a trigger assembly, and a linkage assembly. This structure not only facilitates the assembly and replacement of key components (such as capsules) but also makes cleaning and disinfection more convenient, allowing for flexible selection between single-use and reusable applications and reducing the risk of cross-infection. Furthermore, the components are connected using sliding plug-in joints and guide grooves, ensuring the stability of the overall structure and the smoothness of operation, thus improving the user experience for medical personnel and the convenience of clinical application. Attached Figure Description
[0019] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a disassembly diagram of the present invention; Figure 3This is a cross-sectional view of the needle tube of the present invention; Figure 4 This is a cross-sectional view of the needle tube of the present invention; Figure 5 This is a cross-sectional view of the entire invention; Figure 6 This is the present invention. Figure 5 An enlarged schematic diagram of part A shown in the image; Figure 7 This is a schematic diagram of the installation of the protective component and the lower needle tube of the present invention; Figure 8 This is a schematic diagram showing the connection of the protection component, triggering component, and linkage component of the present invention; Figure 9 This is a schematic diagram of the structure of the protective component of the present invention; Figure 10 This is a schematic diagram of the linkage mechanism of the present invention; Figure 11 This is a partial structural schematic diagram of the triggering component of the present invention.
[0020] The attached diagram lists the components represented by each number as follows: 1. Puncture tube; 11. Upper needle tube; 12. Lower needle tube; 2. Protective components; 3. Triggering components; 4. Linkage components; 111. Guide groove; 112. Lifting rod; 113. Lifting block; 121. Through groove; 122. Movable groove; 123. Pointed cone rod; 124. Return spring; 21. Support section; 22. Compression block; 23. Capsule; 211. Support base; 212. First compression spring; 213. Annular cutter; 214. Hollow rod; 215. Guide block; 216. Gas passage; 31. Puncture tube; 32. Second compression spring; 33. Vent tube; 34. Vent groove; 35. Connector; 36. Inlet groove; 37. Outlet groove; 41. Connecting rod; 42. Linkage rod; 421. Sleeve pole; 422. Telescopic pole. Detailed Implementation
[0021] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
[0022] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.
[0023] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in a preferred embodiment" appearing in different places throughout this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that mutually excludes other embodiments.
[0024] Secondly, the present invention is described in detail with reference to the schematic diagrams. When detailing the embodiments of the present invention, for ease of explanation, the cross-sectional views illustrating the device structure may be partially enlarged, not according to the usual scale. Furthermore, the schematic diagrams are merely examples and should not limit the scope of protection of the present invention. In addition, actual fabrication should include three-dimensional spatial dimensions of length, width, and depth.
[0025] Please see the appendix Figures 1 to 7 As shown, this embodiment provides a testing device for oncology, including a puncture tube 1, which consists of an upper needle tube 11 and a lower needle tube 12; Protective component 2 is disposed inside the puncture tube 1; Trigger component 3 is located on top of protection component 2 and is used to activate the protection mechanism of protection component 2. Linkage component 4 is located at the lower end of the lower needle tube 12; The protective component 2 includes a support part 21, which is slidably connected to the lower needle tube 12. A pressure block 22 is slidably connected to the upper end of the support part 21. A capsule 23 is disposed between the support part 21 and the pressure block 22. The capsule 23 is filled with a composite cryopreservation solution of DMSO and trehalose. The protective function is activated by puncturing the capsule 23 in the protective component 2 by pressing down the trigger component 3.
[0026] In this embodiment, the trigger component 3 is pressed down by an external force. As the trigger component 3 moves downward, it gradually squeezes the capsule 23 located between the support 21 and the pressure block 22. After being subjected to sufficient pressure, the capsule 23 ruptures, releasing the composite cryopreservation solution of DMSO and trehalose that fills it. This composite cryopreservation solution has the function of protecting cells and tissues from damage, and once released, it can quickly form a protective layer around the cells and tissues.
[0027] Furthermore, the puncture tube 1 consists of an upper needle tube 11 and a lower needle tube 12, which are fixed together by means of adhesive, snap-fit, or threaded connection. No specific fixation method is specified here, but it is essential to ensure that the outer surface of the connection between the upper needle tube 11 and the lower needle tube 12 remains smooth to prevent any protrusions from scratching human tissue.
[0028] It should be added that: DMSO can rapidly penetrate cell membranes, lower the freezing point of intracellular solutions, and reduce ice crystal formation. Trehalose, as an osmotic regulator, works synergistically with DMSO to inhibit cell dehydration and stabilize cell membrane structure.
[0029] Ice crystal inhibition: After the microcapsules rupture, the cryopreservation solution preferentially vitrifies, forming an amorphous protective layer that prevents ice crystal growth from causing mechanical damage to cells.
[0030] DMSO's osmotic regulation maintains the osmotic pressure balance inside and outside cells, preventing cell rupture or shrinkage.
[0031] Trehalose, as a surfactant, can repair cell membrane damage and reduce mitochondrial membrane potential disturbances.
[0032] Both Capsule 23 and the compound cryopreservation solution are products that are currently available on the market. When selecting the product, it is necessary to choose one that meets the requirements of this application as much as possible, provided that the specifications and usage scenarios are suitable. Specific models and specifications are not limited here.
[0033] Secondly, please refer to again Figure 3 and Figure 5 The inner ring of the upper needle tube 11 has guide grooves 111 arranged in a ring. The upper end of the upper needle tube 11 is connected to a piston-like lifting rod 112 arranged in a ring. The upper end of the lifting rod 112 is fixedly connected to a lifting block 113.
[0034] In this embodiment, the lifting rod 112 has the ability to linearly displace along the upper needle tube 11, allowing the lifting rod 112 to move smoothly up and down. Furthermore, the lower end of the lifting rod 112 is thicker to prevent it from accidentally detaching from the upper needle tube 11 during use, thereby ensuring the stability and safety of the device.
[0035] Secondly, please refer to Figure 4 and Figure 7 The lower end of the needle tube 12 has a through groove 121 distributed in a ring shape. The lower end of the needle tube 12 also has a movable groove 122. A pointed cone rod 123 is slidably inserted into the movable groove 122. A return spring 124 is fixedly connected between the pointed cone rod 123 and the movable groove 122.
[0036] In this embodiment, the conical rod 123 has the characteristic of extending and retracting along the movable groove 122. In its initial state, the conical rod 123 retracts and is hidden inside the movable groove 122. When puncture is required, the conical rod 123 can smoothly extend along the direction of the movable groove 122. After the puncture task is completed, thanks to the elastic force provided by the return spring 124, the conical rod 123 can quickly return to its initial position, ensuring rapid preparation and efficient operation of the equipment.
[0037] Secondly, please refer to again Figures 6 to 9The support part 21 includes a support base 211, which is slidably inserted into the lower needle tube 12. A first compression spring 212 is fixedly connected to the lower end of the support base 211. An annular cutter 213 is fixedly connected to the bottom surface of the support base 211. Hollow rods 214 are connected in an annular pattern on the top surface of the support base 211. A guide block 215 is fixedly connected to the upper end of the hollow rod 214, and the guide block 215 is slidably connected in the guide groove 111. Gas channels 216 are also opened in an annular pattern on the support base 211, and the gas channels 216 are connected to the hollow rod 214.
[0038] Please refer to it again. Figure 9 The pressure block 22 and the hollow rod 214 are slidably connected, and a rubber sleeve is provided in the through hole through which the pressure block 22 is penetrated by the hollow rod 214. An air outlet groove is also provided at the upper end of the hollow rod 214.
[0039] In this embodiment, a rubber sleeve is provided inside the through hole through which the hollow rod 214 passes through the pressure block 22. The rubber sleeve enhances the friction between the hollow rod 214 and the pressure block 22. Without external force, the pressure block 22 is less likely to slide along the hollow rod 214, thus ensuring that the pressure block 22 can move synchronously with the hollow rod 214 on the support base 211. This prevents the pressure block 22 from separating from the support base 211 due to downward movement of the support base 211, ensuring that the two always maintain a tight fit.
[0040] Please refer to it again. Figures 6 to 9 The linkage component 4 includes a connecting rod 41, which is fixedly connected to the bottom surface of the support base 211, and a linkage rod 42 is fixedly connected to the lower end of the connecting rod 41.
[0041] In this embodiment, in conjunction with CT scanning technology, the puncture tube 1 is precisely guided to the patient's lesion site for sample collection. Initially, the conical rod 123 is positioned within the movable groove 122 to prevent injury to medical personnel during the handling of the puncture tube 1. During the puncture operation, pressure is applied to the lifting block 113, causing it to move synchronously with the lifting rod 112. The movement of the lifting rod 112 applies pressure to the guide block 215, causing it to slide along the guide groove 111. The movement of the guide block 215 drives the hollow rod 214 and the support seat 211 to move synchronously, compressing the first compression spring 212. The movement of the support seat 211 further drives the connecting rod 41 and the linkage rod 42 to move. The movement of the linkage rod 42 applies pressure to the conical rod 123, causing it to extend from the movable groove 122 and compress the return spring 124, at which point the puncture operation can be performed. If vital tissues such as nerve fibers are encountered during the puncture, pressing on the lifting block 113 should be stopped immediately. Subsequently, under the restoring force of the first compression spring 212 and the return spring 124, the pointed rod 123 will retract into the movable groove 122. At this time, puncture can continue towards the lesion site through the hemispherical surface at the lower end of the puncture tube 1 to avoid damage to vital tissues caused by the pointed rod 123 and to ensure patient safety.
[0042] Please refer to it again. Figure 10 The linkage rod 42 includes a sleeve rod 421 and a telescopic rod 422. The sleeve rod 421 is fixedly connected to the connecting rod 41. The upper end of the telescopic rod 422 is slidably inserted into the sleeve rod 421, and the lower end of the telescopic rod 422 extends into the movable groove 122. The inner wall of the sleeve rod 421 has grooves arranged in an array, and the upper end of the telescopic rod 422 has protrusions arranged in an array to match the grooves. The protrusions are made of rubber.
[0043] In this embodiment, the telescopic rod 422 is capable of telescopic movement within the sleeve rod 421.
[0044] Thanks to the cooperation between the groove and the protrusion, when the linkage rod 42 moves downward a certain distance, it pushes the conical rod 123 out of the movable groove 122, while the sleeve rod 421 does not retract with the movement of the telescopic rod 422. Once the conical rod 123 is completely pushed out of the movable groove 122, as the sleeve rod 421 continues to move downward, the telescopic rod 422 will be restricted and unable to move further, causing the telescopic rod 422 to retract into the sleeve rod 421. Specifically, after bearing excessive force, the protrusion will deform and detach from the groove. At this point, the telescopic rod 422 will lose its limiting function and can freely extend and retract within the sleeve rod 421.
[0045] Please refer to it again. Figures 5 to 8 and Figure 11The triggering component 3 includes a puncture tube 31, which is slidably inserted into the pressure block 22. A second pressure spring 32 is fixedly connected to the upper end of the puncture tube 31, and the lower end of the second pressure spring 32 is fixedly connected to the top surface of the pressure block 22. A venting tube 33 is fixedly connected to the upper end of the puncture tube 31, and the upper end of the venting tube 33 is piston-type inserted into the upper needle tube 11. A venting groove 34 is provided in a ring at the lower end of the venting tube 33, and a connector 35 is fixedly installed at the upper end of the venting tube 33. The puncture tube 31 is a hollow tube, and an inlet groove 36 and an outlet groove 37 are provided in a ring on the puncture tube 31.
[0046] In this embodiment, when the tip of the lower needle tube 12 is inserted into the patient's lesion site, the upper end of the ventilation tube 33 should be connected to the negative pressure device, and the device should be activated to perform the air aspiration procedure. The lower end of the ventilation tube 33 is provided with a ventilation groove 34, thereby creating negative pressure at the upper end of the upper needle tube 11; simultaneously, the upper end of the hollow rod 214 is also provided with an air outlet groove, and the hollow rod 214 communicates with the gas channel 216 on the support base 211, allowing gas at the lower end of the lower needle tube 12 to be drawn out through the gas channel 216, the hollow rod 214, and the ventilation tube 33. At this time, negative pressure is generated at the lower end of the lower needle tube 12, causing some cells from the lesion site to be drawn into the lower needle tube 12 through the ventilation groove 121. After cells are aspirated, pressing the lifting block 113 causes the lifting rod 112, guide block 215, hollow rod 214, and support base 211 to move synchronously. The movement of the support base 211 drives the annular cutter 213 downward to its maximum cutting position, removing the cells. The annular cutter 213 also seals the through-slot 121, preventing cells from flowing out of the through-slot 121 or external air from entering and contaminating the cells when the puncture tube 1 is removed, effectively improving sampling stability and cell purity. Negative pressure adsorption should be stopped immediately after the cells are removed by the annular cutter 213.
[0047] After the cells are removed by the circular cutter 213 and the circular cutter 213 seals the through-slot 121, pressure is applied to the venting tube 33, causing the venting tube 33 and the puncture tube 31 to move together. The capsule 23 is punctured using the puncture tube 31. After the capsule 23 ruptures, liquid flows between the support 211 and the pressure block 22. Some liquid flows directly out from the opening at the bottom of the support 211, while the remaining liquid enters the puncture tube 31 along the inlet groove 36 and is then discharged from the outlet groove 37. The discharged cryopreservation solution is rapidly released onto the sample surface. The microcapsules are filled with a composite cryopreservation solution of DMSO and trehalose, achieving rapid cryopreservation protection.
[0048] The device is assembled using a detachable structure. During installation, firstly, the pressure block 22 is pulled upwards along the hollow rod 214, and then the capsule 23 is placed in the elliptical groove on the support base 211. Next, the pressure block 22 moves downwards along the hollow rod 214 until it is tightly fitted against the support base 211, thus securing the capsule 23 through the combined action of the pressure block 22 and the support base 211. Subsequently, the support base 211 on the protective assembly 2 is slid and inserted into the lower needle tube 12, and the lower end of the first compression spring 212 is placed in the annular groove of the lower needle tube 12, ensuring that the linkage rod 42 at the lower end of the support base 211 passes through the movable groove 122. Since the trigger assembly 3 is fixedly connected to the pressure block 22, and the linkage assembly 4 is fixedly connected to the support base 211, once the support base 211 is securely installed in the lower needle tube 12, the linkage assembly 4 and the trigger assembly 3 are also installed in place (see...). Figure 7 Next, align and insert the guide block 215 with the guide groove 111 on the upper needle tube 11, while ensuring that the vent tube 33 extends from the upper end of the upper needle tube 11 to the outside. Finally, securely connect the upper needle tube 11 and the lower needle tube 12.
[0049] It should be noted that when using a threaded connection between the upper needle tube 11 and the lower needle tube 12, the connection is achieved by rotating the lower needle tube 12. Since the support base 211, the first compression spring 212, and the linkage assembly 4 are not engaged or fixed to the lower needle tube 12, the lower needle tube 12 can rotate freely, thus achieving the connection between the upper needle tube 11 and the lower needle tube 12. Thanks to the modular design, replacing the capsule 23 is simple, and the internal components are easy to disassemble for cleaning and maintenance.
[0050] The working principle of this invention is as follows: This oncology testing device achieves safe collection and effective protection of cells and tissues from lesions through the synergistic action of the puncture tube 1, protective component 2, triggering component 3, and linkage component 4. Its core lies in the timely release of a DMSO and trehalose composite cryopreservation solution encapsulated in capsule 23 after sampling, forming an immediate protective layer for cells and tissues to prevent ice crystal formation and mechanical damage. Specifically, before the puncture operation, the device is in its initial state, with the tip rod 123 concealed within the movable groove 122 at the end of the lower needle tube 12, ensuring safe use. When pressure is applied to the lifting block 113, the lifting rod 112 drives the guide block 215 to slide along the guide groove 111, pushing the support base 211 and its hollow rod 214 downwards simultaneously, compressing the first compression spring 212, and propelling the tip rod 123 out for puncture via the linkage component 4. During this process, if nerves or other important tissues are encountered, pressure can be stopped immediately, and the tip rod 123 can be retracted by the return spring 124 to avoid accidental injury. Simultaneously, a negative pressure device is connected via the vent tube 33, creating negative pressure at the end of the lower needle tube 12 to draw the target cells into the channel 121. Then, the annular cutter 213 descends to cut the cell sample and seal the channel 121, preventing sample contamination or loss. After sampling, the trigger component 3 is pressed down further, causing the puncture tube 31 to descend and puncture the capsule 23, releasing the DMSO and trehalose composite cryopreservation solution. This solution rapidly encapsulates the sample, inhibiting ice crystal formation and maintaining cell viability. After the capsule 23 ruptures, the cryopreservation solution flows out from the bottom of the support base 211 and enters through the inlet groove 36 of the puncture tube 31, flowing to the sample surface through the outlet groove 37, achieving rapid vitrification and freezing protection. The entire device adopts a modular design, facilitating disassembly and replacement of the capsule 23 and cleaning and maintenance. Furthermore, the upper needle tube 11 and lower needle tube 12 can be connected in multiple ways, ensuring a smooth outer surface and improving operational safety and ergonomics.
[0051] The above description is merely a preferred embodiment of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention. Structures, devices, and operating methods not specifically described or explained in this invention are implemented according to conventional methods in the art unless otherwise specified or limited.
Claims
1. A testing device for oncology, characterized in that: It includes a puncture tube, which consists of an upper needle tube and a lower needle tube; Protective components are housed inside the puncture tube; Trigger component: The trigger component is set above the protection component to activate the protection mechanism of the protection component; Linkage component, the linkage component is located at the lower end of the lower needle tube; The protective component includes a support part, which is slidably connected inside the lower needle tube. A pressure block is slidably connected to the upper end of the support part, and a capsule is provided between the support part and the pressure block. The protective function is activated by puncturing the capsule in the protective component by pressing down on the trigger component.
2. The oncology testing device according to claim 1, characterized in that: The inner ring of the upper needle tube has guide grooves arranged in a ring, and the upper end of the upper needle tube has a piston-like insertion rod arranged in a ring. The upper end of the lifting rod is fixedly connected to a lifting block.
3. The oncology testing device according to claim 1, characterized in that: The lower end of the needle tube has through grooves arranged in a ring, and a movable groove is also provided at the lower end of the needle tube. A pointed cone rod is slidably inserted into the movable groove, and a return spring is fixedly connected between the pointed cone rod and the movable groove.
4. The oncology testing device according to claim 2, characterized in that: The support includes a support base, which is slidably inserted into the lower needle tube. A first compression spring is fixedly connected to the lower end of the support base. An annular cutter is fixedly connected to the bottom surface of the support base. Hollow rods are connected in an annular pattern on the top surface of the support base. A guide block is fixedly connected to the upper end of the hollow rod and is slidably connected in a guide groove. Gas channels are also opened in an annular pattern on the support base and are connected to the hollow rod.
5. The oncology testing device according to claim 1, characterized in that: The triggering component includes a puncture tube that is slidably inserted into the pressure block. A second pressure spring is fixedly connected to the upper end of the puncture tube, and the lower end of the second pressure spring is fixedly connected to the top surface of the pressure block. A venting tube is fixedly connected to the upper end of the puncture tube, and the upper end of the venting tube is piston-type inserted into the upper needle tube. Venting grooves are distributed in a ring at the lower end of the venting tube, and a connector is fixedly installed at the upper end of the venting tube. The puncture tube is a hollow tube, and inlet grooves and outlet grooves are distributed in a ring on the puncture tube.
6. The oncology testing device according to claim 4, characterized in that: The linkage component includes a connecting rod, which is fixedly connected to the bottom surface of the support base, and a linkage rod is fixedly connected to the lower end of the connecting rod.
7. The oncology testing device according to claim 6, characterized in that: The linkage rod includes a sleeve rod and a telescopic rod. The sleeve rod is fixedly connected to the connecting rod. The upper end of the telescopic rod is slidably inserted into the sleeve rod, and the lower end of the telescopic rod passes through the movable groove.
8. The oncology testing device according to claim 7, characterized in that: The inner wall of the telescopic rod has grooves arranged in an array, and the upper end of the telescopic rod has protrusions arranged in an array to match the grooves, and the protrusions are made of rubber.
9. A testing device for oncology according to claim 4, characterized in that: The pressure block and the hollow rod are slidably connected, and a rubber sleeve is installed in the through hole through which the pressure block is penetrated by the hollow rod. An air outlet groove is also provided at the upper end of the hollow rod.
10. A testing device for oncology according to claim 1, characterized in that: The capsules are filled with a composite cryopreservation solution of DMSO and trehalose.
Citation Information
Patent Citations
Sampling apparatus for medical examination of tumor cells
CN112370086A
