Sesame euphausiid peptide tablet candy capable of protecting both bones and skin and preparation method of sesame euphausiid peptide tablet candy

Abstract

Sodium hyaluronate, colostrum basic protein, krill oil, sea cucumber collagen peptide and the like are used as core raw materials, maltodextrin and other auxiliary materials are compounded, and a low-temperature pretreatment (less than or equal to 55 DEG C) + krill oil micro-capsule embedding + precise tabletting process is adopted to prepare the sesame krill peptide tablet candy. The product mainly has three-dimensional effects of bone maintenance, skin moisturizing and fatigue resistance, and fills the blank of single-effect food for sub-healthy people such as 30-55-year-old sedentary workplaces and postpartum mothers. The low-temperature process protects the activity of basic protein in the colostrum, the microcapsule embedding covers the oil smell of the krill, and the palatability of the finished product is greater than or equal to 8.5 min (10 min). A pre-test shows that the joint discomfort relieving rate is 73%, the skin water content is increased by 15%, and the fatigue score is reduced by 28% (Plt; according to the method disclosed by the invention, the quality guarantee period is 24 months, middle-and-high-end functional tabletted candies are positioned, and the method has industrial feasibility.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of functional tablet candies, in particular to a "bone-skin dual protection" sesame phosphorus shrimp peptide tablet candy with the effects of bone and skin protection and daily anti-fatigue, and a preparation method thereof, which is especially suitable for sub-health people aged 30-55 (such as people working in sedentary jobs and postpartum mothers) and can be used as a long-term food of medium and high-end functional foods. BACKGROUND

[0002] With the acceleration of modern life pace and the change of work and rest mode, people aged 30-55 in cities are facing multiple health pain points: people working in sedentary jobs are prone to joint stiffness and discomfort due to lack of exercise; postpartum mothers are affected by hormone changes and parenting pressure, and their skin moisture loss is accelerated and fatigue accumulates; and existing functional tablet candies mostly focus on single effect (such as only bone protection or only skin protection), which is difficult to meet the multiple regulation needs of "skeleton-skin-fatigue". In addition, some products containing phosphorus shrimp oil have poor palatability because they have not been treated to mask the fishy smell; traditional high-temperature granulation (≥60℃) process easily leads to denaturation and inactivation of heat-sensitive active ingredients such as colostrum basic protein and sodium hyaluronate, reducing the product efficacy; at the same time, some products have problems such as insufficient mixing uniformity and large deviation of active ingredient content, affecting the safety and stability of food. Therefore, it is an urgent need in the current market to develop a functional tablet candy with multiple effects, high active retention rate, good palatability and compliance with national standards. SUMMARY

[0003] The present application aims to solve the problems of single effect, easy inactivation of active ingredients and poor palatability of existing functional tablet candies, and provides a "bone-skin dual protection" sesame phosphorus shrimp peptide tablet candy and a preparation method thereof, realizing the synergistic effect of "skeleton protection-skin moisturizing-anti-fatigue" and ensuring the activity, palatability and stability of the product.

[0004] (I) Raw material composition of tablet candy (by weight) 1. Main raw materials Black sesame: 10-12 parts, raw materials from the selenium-rich production area of Zhumadian, Henan, baked at 60℃ for 2h, retaining ≥8% unsaturated fatty acids and vitamin E, with the functions of flavor supply and nutrient supplementation, reducing the dependence on food additives; Sodium hyaluronate: 0.15-0.2 parts, food grade (in line with the No. 1 announcement of the Health Commission in 2022), molecular weight 100-300kDa, easy to absorb, can supplement the moisture of skin and joint synovial fluid, daily dosage ≤ national standard limit (200mg / day); N-acetylglucosamine: 1.4-1.6 parts, produced by fermentation method (purity ≥98%), is the core component of joint cartilage matrix synthesis, promotes cartilage repair, and the dosage is in line with the conventional effective dosage of functional foods; Milk basic protein: 0.04-0.06 parts, imported from New Zealand, with an active ingredient content of ≥85%, activates the activity of enzymes related to intestinal calcium absorption, and meets the application standards for bone health foods; Colostrum basic protein: 0.015-0.025 parts, derived from bovine colostrum (IgG content ≥20%), activates osteoblast proliferation, and complies with the limits for the use of non-ingredient ingredients in infant formula; Hydrolyzed egg yolk powder: 0.25-0.35 parts, containing bone mineralization promoting factors, which is a clinically validated effective dose; Krill oil: 1.7-1.9 parts, extracted from Antarctic krill, with phospholipid DHA / EPA content ≥40%, daily dosage ≤ national standard limit (2g / day), phospholipid structure enhances Omega-3 absorption rate; Sea cucumber collagen peptides: 0.9-1.1 parts, prepared from Dalian sea cucumber by enzymatic hydrolysis with compound protease (50℃, 4h), molecular weight 500-1000Da, absorption rate ≥95%, assisting in skin collagen replenishment and anti-fatigue.

[0005] 2. Excipients Maltodextrin: 4.8-5.2 parts, conforming to GB15203-2021 "National Food Safety Standard for Starch Sugar", used as a binder to improve granule formability; Sorbitol: 0.9-1.1 parts, meeting the limit of GB2760-2024 (≤5%), sweetener (sweetness of 60% of sucrose), non-cariogenic; Magnesium stearate: 0.09-0.11 parts, conforming to GB1886.91-2016 "National Food Safety Standard for Food Additives Magnesium Stearate", lubricant, to prevent tablet sticking during compression.

[0006] (II) Preparation method This method achieves activity retention and palatability optimization through precise process control. The specific steps are as follows: 1. Raw material pretreatment Black sesame processing: Screening (to remove impurities) → Rinse twice with purified water (to remove dust) → Low-temperature baking at 60℃ for 2 hours (moisture content controlled ≤8%) → Ultrafine grinding (particle size ≤100 mesh, no sandy feel) to obtain black sesame powder; Krill oil microencapsulation: Krill oil and maltodextrin-gum arabic wall material (3:1) were mixed (stirred at 40℃, 200r / min for 30min) → homogenized under high pressure at 30MPa → spray dried (inlet air 180℃, outlet air 80℃, moisture ≤4%) to obtain krill oil microencapsulation powder, avoiding fishy smell and oxidation of DHA / EPA. Water-soluble raw material processing: Sodium hyaluronate, N-acetylglucosamine, and sea cucumber collagen peptides are dissolved in purified water at ≤30℃ → concentrated under vacuum at 60℃ and -0.08MPa (solid content ≥60%) to obtain a water-soluble paste, protecting the heat-sensitive active ingredients.

[0007] 2. Mixing Step 1: Put black sesame powder, milk alkaline protein, colostrum alkaline protein, and hydrolyzed egg yolk powder into a SYH-100 three-dimensional mixer and mix at 150 rpm for 15 minutes. Step 2: Add krill oil microcapsule powder and water-soluble paste, then add maltodextrin and sorbitol, and continue mixing for 20 minutes to ensure a mixing uniformity of ≥98% and to guarantee that the active ingredient content of each tablet is consistent (deviation ≤±5%).

[0008] 3. Granulation Wet granulation is used, with the addition of 5% hydroxypropyl methylcellulose solution (binder), granulation temperature ≤50℃, particle size 1.2-1.5mm, and granulation through a 16-mesh sieve.

[0009] 4. Drying Hot air circulation drying (55℃, 2h) is used to dry the particles until the moisture content is ≤4%. The particles are then cooled to room temperature of 25℃ to avoid denaturation of the active ingredients.

[0010] 5. Tableting The ZP-35A rotary tablet press is used, with a pressure of 20kN and a rotation speed of 30r / min. The tablet size is 0.5g / tablet (8mm in diameter, round, with smooth edges).

[0011] 6. Packaging The DPP-140 aluminum-plastic blister packaging machine is used, with a capacity of 60 pieces / min, 12 pieces / blister, and 3 blister packs / box (36 pieces / box), which extends the shelf life.

[0012] (III) Key Control Points Krill oil microencapsulation: temperature ≤40℃, control peroxide value ≤5meq / kg to prevent DHA / EPA oxidation; Dissolving water-soluble raw materials: Temperature ≤30℃, to protect the activity of sodium hyaluronate and sea cucumber collagen peptides; Granulation and drying: Temperature ≤55℃, ensuring that the basic protein activity retention rate of colostrum is ≥90%; Mixing uniformity: ≥98%, avoiding deviations in active ingredient content (≤±5%); Finished product moisture content: ≤5%, to prevent moisture absorption and softening, ensuring a shelf life of 24 months.

[0013] (iv) Mechanism of Efficacy Bone and joint care: N-acetylglucosamine promotes cartilage matrix synthesis, milk basic protein enhances calcium absorption, colostrum basic protein activates osteoblasts, and hydrolyzed egg yolk powder accelerates bone mineralization. The four work together to improve joint discomfort. Skin moisturizing and anti-aging: Sodium hyaluronate replenishes skin moisture, while sea cucumber collagen peptides promote collagen synthesis and improve skin hydration. Daily fatigue relief: Krill oil (DHA / EPA) regulates metabolism, while black sesame (unsaturated fatty acids) replenishes energy and alleviates fatigue, forming a "three-dimensional synergistic" efficacy system. Detailed Implementation

[0014] The present invention is further illustrated below by way of preferred embodiments, but these do not constitute a limitation on the scope of protection of the present invention.

[0015] Example 1: Preparation of Preferred "Bone and Skin Dual Protection" Sesame Krill Peptide Compressed Candy 1. Raw material composition (by weight) Main ingredients: 10 parts black sesame seeds, 0.18 parts sodium hyaluronate, 1.5 parts N-acetylglucosamine, 0.05 parts milk basic protein, 0.02 parts colostrum basic protein, 0.3 parts hydrolyzed egg yolk powder, 1.8 parts krill oil, and 1.0 part sea cucumber collagen peptide; Excipients: 5.0 parts maltodextrin, 1.0 part sorbitol, 0.1 part magnesium stearate.

[0016] 2. Preparation steps Raw material pretreatment: Black sesame seeds roasted at 60℃ for 2 hours (moisture content 7.5%) → ultrafine grinding (particle size 90 mesh); krill oil and maltodextrin-gum arabic (3:1) mixed at 40℃ for 30 minutes → homogenized at 30MPa → spray drying (inlet air 180℃, outlet air 80℃, microcapsule powder moisture content 3.8%); water-soluble raw materials such as sodium hyaluronate dissolved in purified water at 28℃ → vacuum concentration (solids content 62%). Mixing: First, mix solid raw materials such as black sesame powder in a three-dimensional mixer at 150 rpm for 15 minutes, then add microcapsule powder and paste, add auxiliary materials and mix for 20 minutes, achieving a uniformity of 98.5%; Granulation: wet granulation at 50℃, particle size 1.3mm, passing through a 16-mesh sieve; Drying: Dry at 55℃ for 2 hours (particle moisture content 3.9%), then cool to 25℃; Tableting: 20kN pressure, 30r / min rotation speed, compressed into 0.5g / tablet (8mm in diameter); Packaging: Aluminum-plastic blister packaging, 12 pieces / blister, 3 blister packs / box.

[0017] 3. Finished product performance testing Palatability: Rating 8.7 out of 10 (no krill oil fishy taste); Activity retention rate: 92% of the basic protein activity was retained in colostrum, and there was no loss of activity in sodium hyaluronate; Efficacy verification: After 30 days of continuous consumption, the joint discomfort relief rate was 73%, skin moisture content increased by 15%, and fatigue score decreased by 28% (P<0.05). Compliance: Complies with GB17403-2016 "National Food Safety Standard for Candy", moisture content 4.2%, shelf life 24 months.

[0018] Comparative example (prepared using traditional methods) High-temperature granulation at 65℃ and microencapsulation without krill oil were used, with the other raw materials the same as in Example 1. The results showed that the retention rate of colostrum basic protein activity was only 68%, the finished product had a distinct krill oil fishy smell (palliative score 5.2), the joint discomfort relief rate decreased to 51%, skin moisture content increased by 8%, fatigue score decreased by 15%, and the finished product moisture content was 5.8%, with the shelf life shortened to 18 months, which was significantly inferior to the present invention.

[0019] Beneficial effects Compared with the prior art, the present invention has the following beneficial effects: Multiple and synergistic effects: Breaking through the limitations of single effects, it achieves three-dimensional conditioning of "bones-skin-fatigue", which is suitable for the core needs of sub-healthy people aged 30-55; High activity retention rate: Through low-temperature process (granulation and drying) at ≤55℃ and water-soluble raw material treatment at ≤30℃, the retention rate of active ingredients such as colostrum basic protein is ≥90%, resulting in more stable efficacy; Excellent palatability: Krill oil is microencapsulated to mask the fishy smell, and black sesame provides a roasted flavor. The finished product has a palatability score of ≥8.5, which improves the acceptability of eating it. Stable and controllable quality: Mixing uniformity ≥98%, active ingredient content deviation ≤±5%, finished product moisture ≤5%, meets national standards and has a shelf life of 24 months; High feasibility for industrialization: The process steps are clearly defined (pretreatment-mixing-granulation-tableting-packaging), the equipment is conventional (three-dimensional mixer, rotary tablet press), and large-scale production can be achieved, with significant cost-effectiveness advantages.

[0020] The above embodiments are merely preferred embodiments of the present invention. Any modifications or equivalent substitutions within the scope of the present invention are protected by the present invention.

Claims

1. A "bone and skin dual protection" sesame krill peptide compressed candy, characterized in that, The product contains the following ingredients by weight: 10.69-14.925 parts core ingredients (including 10-12 parts black sesame seeds, 0.15-0.2 parts sodium hyaluronate, 1.4-1.6 parts N-acetylglucosamine, 0.04-0.06 parts milk basic protein, 0.015-0.025 parts colostrum basic protein, 0.25-0.35 parts hydrolyzed egg yolk powder, 1.7-1.9 parts krill oil, and 0.9-1.1 parts sea cucumber collagen peptides), and 5.79 parts auxiliary ingredients. -6.41 parts (containing 4.8-5.2 parts maltodextrin, 0.9-1.1 parts sorbitol, and 0.09-0.11 parts magnesium stearate); prepared using the process of "low-temperature pretreatment + krill oil microencapsulation + precision tableting", wherein the low-temperature pretreatment and granulation drying temperature is ≤55℃, and the krill oil microencapsulation uses maltodextrin-gum arabic wall material (weight ratio 3:1). The finished product is a functional compressed candy with the effects of bone and joint care, skin moisturizing and anti-aging, and daily anti-fatigue.

2. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The black sesame seeds are roasted at 60℃ for 2 hours (moisture content controlled ≤8%) and then ultra-finely pulverized, with a particle size ≤100 mesh after pulverization.

3. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The krill oil is an extract of Antarctic krill, with a phospholipid DHA / EPA content of ≥40%; the krill oil microencapsulation temperature is ≤40℃, the high-pressure homogenization pressure is 30MPa, the spray drying inlet air temperature is 180℃ and the outlet air temperature is 80℃, the microencapsulation powder moisture content is ≤4%, and the peroxide value is ≤5meq / kg.

4. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The sodium hyaluronate is food grade with a molecular weight of 100-300 kDa; the N-acetylglucosamine is produced by fermentation and has a purity of ≥98%.

5. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The colostrum contains ≥20% basic protein IgG; the milk contains ≥85% basic protein active ingredients.

6. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The sea cucumber collagen peptides are prepared from Dalian sea cucumbers by enzymatic hydrolysis with a complex protease. The hydrolysis temperature is 50℃ and the hydrolysis time is 4h. The molecular weight is 500-1000Da and the absorption rate is ≥95%.

7. The preparation method of the "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that, Includes the following steps: (1) Raw material pretreatment: Black sesame seeds are screened → washed → baked at 60℃ → ultra-finely pulverized; krill oil and maltodextrin-gum arabic (3:1) are mixed → homogenized → spray dried to obtain microcapsule powder; sodium hyaluronate, N-acetylglucosamine, and sea cucumber collagen peptides are dissolved in purified water at ≤30℃ → vacuum concentrated (60℃, vacuum degree -0.08MPa) to obtain paste; (2) Mixing: first mix black sesame powder, milk basic protein, colostrum basic protein, and hydrolyzed egg yolk powder for 15 min, then Add krill oil microcapsule powder, paste and excipients and mix for 20 min, the mixing uniformity is ≥98%; (3) Granulation: add 5% hydroxypropyl methylcellulose solution, granulation temperature ≤50℃, particle size 1.2-1.5mm; (4) Drying: dry with hot air circulation at 55℃ for 2 h, particle moisture ≤4%; (5) Tableting: pressure 20kN, speed 30r / min, compress into 0.5g / tablet (diameter 8mm); (6) Packaging: aluminum-plastic blister packaging, 12 tablets / blister, 3 blister / box.

8. The preparation method according to claim 7, characterized in that: In step (1), the dissolution temperature of water-soluble raw materials is ≤30℃; in steps (3)-(4), the granulation and drying temperature is ≤55℃, the retention rate of colostrum basic protein activity is ≥90%; the moisture content of the finished product is ≤5%, the palatability score is ≥8.5 points (out of 10), and the shelf life is 24 months.

9. The "Bone and Skin Dual Protection" sesame krill peptide compressed candy according to claim 1, characterized in that: The compressed candy is suitable for sub-healthy people such as sedentary office workers aged 30-55 and postpartum mothers. Continuous consumption for 30 days can achieve a joint discomfort relief rate of ≥73%, skin moisture content increase of ≥15%, and fatigue score reduction of ≥28% (P<0.05).