Traditional Chinese medicine composition for treating diabetic skin ulcer as well as preparation method and application of traditional Chinese medicine composition
The combination of mulberry leaf water and phellodendron bark powder solves the problems of insufficient local blood sugar reduction and slow ulcer healing in existing treatments for diabetic skin ulcers, achieving rapid healing and cost-effective treatment results.
Patent Information
- Application Number
- CN202511999386.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-26
- Publication Date
- 2026-02-03
AI Technical Summary
Existing treatments for diabetic skin ulcers present challenges such as difficulty in controlling blood sugar, risk of wound expansion, high treatment costs, poor patient tolerance, and lack of local blood sugar-lowering effects.
A traditional Chinese medicine composition using mulberry leaf decoction and phellodendron bark powder is prepared by charcoal burning and calcining mulberry leaves and phellodendron bark powder. The powder is then mixed with water and decocted to make mulberry leaf decoction, which is used for local treatment of diabetic skin ulcers. It has the effects of local hypoglycemic effect and promoting ulcer healing.
It achieves rapid ulcer healing without the need for systemic blood sugar lowering, reducing patient suffering and financial burden, and has low raw material costs.
Smart Images
Figure CN121445809A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a traditional Chinese medicine composition, its preparation method, and its application. Background Technology
[0002] Diabetic skin diseases are specific skin manifestations of diabetes. In diabetic patients, disordered immune regulation and elevated blood sugar levels create an environment conducive to pathogen proliferation. Diabetic neuropathy makes the skin susceptible to damage and slow to heal. Diabetic-related skin diseases mainly include diabetic dermatitis, diabetic bullous disease, diabetic skin infections, diabetic pruritus, and diabetic skin ulcers. While some treatments exist for diabetic skin ulcers, these methods have the following limitations: Drug treatment: Blood sugar control is difficult, and some hypoglycemic drugs may cause hypoglycemia, gastrointestinal reactions, etc., which affect the patient's quality of life.
[0003] Debridement: Risks include wound enlargement, increased risk of infection, and prolonged healing time; patients with poor tolerance may not be able to tolerate multiple debridement procedures, such as the elderly or those in poor physical condition.
[0004] Interventional treatments (such as balloon angioplasty and stent placement): Postoperative vascular stenosis may occur, requiring multiple treatments, and the overall treatment cost is high.
[0005] Amputation: It severely affects the quality of life, leads to limb loss, and causes psychological trauma and inconvenience to patients.
[0006] Existing products for treating diabetic skin ulcers do not have local hypoglycemic effects or anti-diabetic ulcer functions. Summary of the Invention
[0007] The purpose of this invention is to provide a traditional Chinese medicine composition, its preparation method, and its application. The traditional Chinese medicine composition of this invention can exert a local hypoglycemic effect, promote rapid healing of ulcers, treat diabetic ulcers, and alleviate the suffering and economic burden of patients with diabetic skin ulcers.
[0008] This invention provides a traditional Chinese medicine composition comprising mulberry leaf water and a second component; the second component comprises mulberry leaf powder and / or phellodendron bark powder; all components are packaged separately. The method for preparing mulberry leaf powder includes the following steps: charring mulberry leaves, pulverizing them, and obtaining mulberry leaf powder; The preparation method of the Phellodendron bark powder includes the following steps: calcining Phellodendron bark and pulverizing it to obtain Phellodendron bark powder; The method for preparing mulberry leaf water includes the following steps: mixing mulberry leaves and water, boiling, filtering, and obtaining mulberry leaf water.
[0009] Preferably, the charcoal roasting includes: heating from 180°C to 200°C and roasting for 20-40 minutes.
[0010] Preferably, the calcination includes: calcining at 160~170℃ for 30~40 min, calcining at 220℃ for 20~30 min, and calcining at 270℃ for 15~20 min; or the calcination includes: calcining at room temperature to 600℃ for 60~80 h.
[0011] Preferably, the volume of water is 3 to 4 times that of mulberry leaves; and the decoction time is 10 to 15 minutes.
[0012] The present invention also provides a method for preparing the traditional Chinese medicine composition described in the above technical solution, comprising the following steps: charring mulberry leaves, pulverizing them, and obtaining mulberry leaf powder; Phellodendron bark is calcined and pulverized to obtain phellodendron bark powder; Mix mulberry leaves and water, boil, and filter to obtain mulberry leaf water.
[0013] Preferably, the charcoal roasting includes: heating from 180°C to 200°C and roasting for 20-40 minutes.
[0014] Preferably, the calcination includes: calcining at 160~170℃ for 30~40 min, calcining at 220℃ for 20~30 min, and calcining at 270℃ for 15~20 min; or the calcination includes: calcining at room temperature to 600℃ for 60~80 h.
[0015] Preferably, the volume of water is 3 to 4 times that of mulberry leaves; and the decoction time is 10 to 15 minutes.
[0016] The present invention also provides a traditional Chinese medicine preparation, which includes mulberry leaf water or the traditional Chinese medicine composition described in the above technical solution or the traditional Chinese medicine composition prepared by the preparation method described in the above technical solution and pharmaceutically acceptable excipients; the preparation method of the mulberry leaf water includes the following steps: mixing mulberry leaves and water, decocting, filtering, and obtaining mulberry leaf water.
[0017] The present invention also provides the application of mulberry leaf water or the traditional Chinese medicine composition described in the above technical solution or the traditional Chinese medicine composition prepared by the preparation method described in the above technical solution in the preparation of a drug for treating diabetic skin ulcers; the preparation method of the mulberry leaf water includes the following steps: mixing mulberry leaves and water, decocting, filtering, and obtaining mulberry leaf water.
[0018] This invention provides a traditional Chinese medicine composition comprising separately packaged mulberry leaf powder and / or phellodendron bark powder and mulberry leaf decoction. The traditional Chinese medicine composition of this invention can treat diabetic skin ulcers, offering advantages such as local hypoglycemia, promoting rapid ulcer healing, alleviating pain, shortening hospital stays, and reducing economic burden. It exhibits significant therapeutic effects and low raw material costs.
[0019] The present invention also provides a method for preparing the traditional Chinese medicine composition. The method for preparing the traditional Chinese medicine composition of the present invention is simple and has broad application value. Attached Figure Description
[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0021] Figure 1 A physical image of the mulberry leaf ink toner provided by this invention; Figure 2 The image shows a physical sample of the Phellodendron bark coke powder provided by this invention. Figure 3 A physical image of mulberry leaf water provided for this invention; Figure 4 The image provided by this invention is a real photograph of Mr. Zhang before treatment of diabetic foot (August 1, 2022). Figure 5 A photograph taken on August 8, 2022, showing the diabetic foot of Mr. Zhang after treatment with the traditional Chinese medicine composition of this invention. Figure 6 A photograph taken on September 11, 2022, showing the diabetic foot of Mr. Zhang after treatment with the traditional Chinese medicine composition of this invention. Figure 7 This is a photograph of Mr. Wang's first application of medication to a diabetic neck ulcer, provided by the present invention. Figure 8 This is a photograph of Mr. Wang's second dose of medication for diabetic neck ulcers, provided by the present invention. Figure 9 The images provided by this invention are real photographs of Wang Moumou's diabetic neck ulcer healing. Figure 10 The image provided by this invention shows a patient surnamed Chao before the treatment of postoperative ulceration of breast cancer wound (July 26, 2023). Figure 11 The image provided by this invention shows the postoperative wound ulceration of Ms. Chao after breast cancer surgery (August 30, 2023). Figure 12The above image shows the healing of a breast cancer surgery wound (October 15, 2023) provided for this invention. Figure 13 Before treatment of calf ulcers in Mr. Feng, provided for this invention (June 9, 2022); Figure 14 The image provided by this invention shows the patient's leg ulcer after treatment. Detailed Implementation
[0022] This invention provides a traditional Chinese medicine composition comprising mulberry leaf water and a second component; the second component comprises mulberry leaf powder and / or phellodendron bark powder; all components are packaged separately. The method for preparing mulberry leaf powder includes the following steps: charring mulberry leaves, pulverizing them, and obtaining mulberry leaf powder; The preparation method of the Phellodendron bark powder includes the following steps: calcining Phellodendron bark and pulverizing it to obtain Phellodendron bark powder; The method for preparing mulberry leaf water includes the following steps: mixing mulberry leaves and water, boiling, filtering, and obtaining mulberry leaf water.
[0023] This invention involves charring and pulverizing mulberry leaves to obtain mulberry leaf powder. In a specific embodiment, the mulberry leaves are dried mulberry leaves. In a specific embodiment, the mulberry leaves are those harvested after frost. In a specific embodiment, the charring includes charring at 180℃ to 200℃ for 20-40 minutes. This invention does not specify a particular pulverizing method; conventional pulverizing methods, such as grinding, are acceptable. The mulberry leaf powder prepared by this invention can also be called mulberry leaf charcoal powder, etc. Figure 1 As shown. The mulberry leaf charcoal powder of the present invention can be stored in a clean, dry glass container. There is currently no mulberry leaf powder on the market for treating diabetic ulcers.
[0024] This invention involves calcining and pulverizing Phellodendron amurense to obtain Phellodendron amurense powder. In a specific embodiment, the Phellodendron amurense is dried. In a specific embodiment, the Phellodendron amurense powder can be Phellodendron amurense coke powder or Phellodendron amurense charcoal powder. In a specific embodiment, the calcination includes: calcining at 160-170℃ for 30-40 minutes, raising the temperature to 220℃ for 20-30 minutes, and raising the temperature to 270℃ for 15-20 minutes to obtain Phellodendron amurense coke powder; or the calcination includes: raising the temperature from room temperature to 600℃ and calcining for 60-80 hours to obtain Phellodendron amurense charcoal powder. This invention does not have a special limitation on the pulverization method; conventional pulverization methods, such as grinding, are acceptable. In a specific embodiment, sieving is also included after pulverization. In a specific embodiment, sieving includes passing through a 60-80 mesh sieve. This invention calcines Phellodendron amurense into coke, which is golden yellow in color. Figure 2As shown. This invention, through calcination, can also calcine Phellodendron bark into black charcoal, which is black in color. The moisture content of the charcoal powder of this invention is 6%–7%. The Phellodendron bark powder of this invention is stored in a sealed container. Phellodendron bark is a heat-clearing medicine, with functions and indications of clearing heat and drying dampness, purging fire and detoxifying, and reducing deficiency heat. In this invention, Phellodendron bark has antibacterial, anti-ulcer, and blood sugar-lowering effects, playing a prominent role in drying dampness and reducing swelling. The Phellodendron bark charcoal powder prepared by this invention has a stronger drying function, reduces swelling faster, and has a better effect.
[0025] This invention involves mixing mulberry leaves and water, decocting, and filtering to obtain mulberry leaf water. In a specific embodiment, the volume of water is 3-4 times that of the mulberry leaves; the decoction time is 10-15 minutes. The decoction can be performed in a porcelain pot, and the use of a porcelain pot does not affect the efficacy. The mulberry leaves used in this invention are frost-covered mulberry leaves. The mulberry leaves used in this invention are dried frost-covered leaves. After mixing the mulberry leaves and water, the mixture is brought to a boil over high heat, then simmered over low heat for decoction. After decoction, the mixture is cooled and filtered to obtain mulberry leaf water. The mulberry leaf water of this invention can be stored in glass containers, and can be sterilized by high-pressure steam before storage. The mulberry leaf water obtained by the specific preparation method of this invention can have a local hypoglycemic effect, promote rapid healing of ulcers, achieve the treatment of diabetic ulcers, and reduce the pain and economic burden of patients with diabetic skin ulcers.
[0026] The traditional Chinese medicine composition of this invention has a therapeutic effect on diabetic skin ulcers. Mulberry leaves are used as a diaphoretic and wind-heat dispersant. In this invention, mulberry leaves have antibacterial, hypoglycemic, and anti-ulcer effects. The combination of mulberry leaf water with mulberry leaf powder and / or phellodendron bark powder can achieve highly effective treatment of diabetic skin ulcers. Existing drugs for treating diabetic skin ulcers, such as Yunnan Baiyao Panax notoginseng powder and sore ulcer powder, do not have a local hypoglycemic effect. Compared with Yunnan Baiyao Panax notoginseng powder and sore ulcer powder, the traditional Chinese medicine composition of this invention has better efficacy, achieving treatment of diabetic skin ulcers without systemic hypoglycemia. Ulcers heal quickly, treatment time is short, and patient suffering and economic burden are reduced.
[0027] The present invention also provides a method for preparing the traditional Chinese medicine composition described in the above technical solution, comprising the following steps: charring mulberry leaves, pulverizing them, and obtaining mulberry leaf powder; Phellodendron bark is calcined and pulverized to obtain phellodendron bark powder; Mix mulberry leaves and water, boil, and filter to obtain mulberry leaf water.
[0028] In a specific embodiment, the specific preparation conditions of the mulberry leaf powder, phellodendron bark powder and mulberry leaf water are as described above, and will not be repeated here.
[0029] This invention also provides a method of using the aforementioned traditional Chinese medicine composition. When the ulcer is superficial, the mulberry leaf water from the traditional Chinese medicine composition of this invention can be used to wipe the superficial ulcer surface, and mulberry leaf powder can be applied to the wound. Treatment of superficial ulcers may further include covering the ulcer surface with 3-4 layers of dressing soaked in mulberry leaf water after wiping it with the mulberry leaf water. When the ulcer is deep, it can be rinsed with mulberry leaf water, then the wound can be filled with dressing soaked in mulberry leaf water, and the area around the wound can be covered with phellodendron bark powder and / or mulberry leaf powder. In a specific embodiment, the thickness of the phellodendron bark powder coverage can be 1-3 mm, which promotes blood circulation and reduces swelling. For large ulcers with severe swelling, phellodendron bark charcoal powder can be used, as it has a stronger ability to reduce swelling.
[0030] This invention also provides a traditional Chinese medicine preparation comprising mulberry leaf water, or the traditional Chinese medicine composition described in the above-mentioned technical solutions, or the traditional Chinese medicine composition prepared by the preparation method described in the above-mentioned technical solutions, and pharmaceutically acceptable excipients. The preparation method of the mulberry leaf water includes the following steps: mixing mulberry leaves and water, decocting, and filtering to obtain mulberry leaf water. In a specific embodiment, the excipients may be physiological saline, iodine solution, dressings, bandages, or medical tape. In a specific embodiment, the dressing may be used after being soaked in mulberry leaf water.
[0031] This invention also provides a method for using the aforementioned traditional Chinese medicine preparation. This invention uses the aforementioned traditional Chinese medicine preparation to treat and / or change dressings for diabetic skin ulcers. Specifically, before rinsing with mulberry leaf water, this invention can clean the wound with physiological saline; for wounds with necrotic tissue, the necrotic tissue should be trimmed away. Before rinsing with mulberry leaf water, it is also possible to disinfect with povidone-iodine and then rinse again with physiological saline. After rinsing with mulberry leaf water, for shallow wounds, 3-4 layers of dressing soaked in mulberry leaf water can be applied, or mulberry leaf powder can be directly applied to the wound; for deep wounds, dressing strips soaked in mulberry leaf water can be used for packing (to lower blood sugar). When there is edema around the wound, mulberry leaf powder and / or phellodendron bark powder can be sprinkled around the wound (to promote blood circulation and reduce swelling). After applying or sprinkling mulberry leaf powder and / or phellodendron bark powder, this invention can cover the entire wound with a dressing (with one side covered by a thin layer of medical cotton to secure the powder and prevent it from being exposed). Limbs are secured with bandages (easy to fix, breathable, and conducive to wound healing), while trunk wounds are secured with medical tape. For significant edema, change the dressing daily; after the swelling subsides, change the dressing every 2-3 days, or adjust the frequency according to the wound's condition. For shallower wounds, the herbal preparation can be taken home for home treatment.
[0032] This invention also provides the application of mulberry leaf water or the traditional Chinese medicine composition described in the above-mentioned technical solutions or the traditional Chinese medicine composition prepared by the preparation method described in the above-mentioned technical solutions in the preparation of a drug for treating diabetic skin ulcers; the preparation method of the mulberry leaf water includes the following steps: mixing mulberry leaves and water, decocting, filtering, and obtaining mulberry leaf water. The traditional Chinese medicine composition of this invention can treat diabetic skin ulcers, has the effect of local hypoglycemia, promotes rapid ulcer healing, has significant curative effect and low raw material cost. In a specific embodiment, the diabetic skin ulcer can specifically be diabetic foot or ulcers in other parts of the body caused by diabetes.
[0033] To further illustrate the present invention, the following detailed description, in conjunction with embodiments, provides a traditional Chinese medicine composition, its preparation method, and its application, but these descriptions should not be construed as limiting the scope of protection of the present invention.
[0034] Example 1 Take dried Phellodendron bark, calcine it at 170℃ for 40 minutes, then raise the temperature to 220℃ for 30 minutes, and finally raise the temperature to 270℃ for 20 minutes, calcining it into coke (golden yellow). Grind it into powder and sift it through a sieve (60 mesh) to obtain Phellodendron bark coke powder, as shown below. Figure 2 As shown. Seal and keep for later use.
[0035] Take dried Phellodendron bark and calcine it at 600℃ from room temperature (30℃) for 72 hours. The calcined product is black charcoal. Grind it into powder and sift it through a sieve (60 mesh) to obtain Phellodendron bark black charcoal powder.
[0036] Pour 1000ml of purified water into a clean, dry glass container and place it in a porcelain pot. Wash 300g of dried mulberry leaves (after frost) and add them to the pot. Bring to a boil over high heat, then simmer over low heat for 10 minutes. Let cool and filter to obtain mulberry leaf water. Figure 3 As shown. Pour into a glass container and send to the preparation room for high-temperature sterilization for later use.
[0037] Dried mulberry leaves (after frost) are charred (from 180℃ to 200℃ and charred for 40 minutes), then ground into powder to obtain mulberry leaf powder, also known as mulberry leaf carbon powder. Figure 1 As shown. Place in a clean, dry glass container for later use.
[0038] Comparative Example 1 Dried Phellodendron bark was calcined at 80℃ for 150 minutes, ground into powder, and sieved to obtain Phellodendron bark powder. Under these conditions, sieving resulted in a large amount of Phellodendron bark residue, requiring repeated sieving three times. The Phellodendron bark powder prepared in Comparative Example 1 showed poor anti-swelling effect and insignificant therapeutic effect.
[0039] Comparative Example 2 The Yunnan Baiyao Panax notoginseng powder and Chuangyangling sold on the market are only effective for diabetic skin ulcers if the patient is hospitalized in the endocrinology department for blood sugar control treatment. After discharge, patients routinely take hypoglycemic drugs, but most patients have unstable blood sugar levels, and Yunnan Baiyao Panax notoginseng powder and Chuangyangling do not have a local hypoglycemic effect, so the ulcers will become larger and more festering.
[0040] The herbal composition in this application can achieve ulcer healing while lowering blood sugar locally, without the need for hospitalization or systemic blood sugar control. It can be achieved by taking regular hypoglycemic drugs, and the therapeutic effect is significant.
[0041] Example 2 Case 1 Mr. Zhang, male, 62 years old, has suffered from diabetes for many years. In June 2022, ulceration began to appear on the dorsum of his right foot. He sought medical treatment from various sources, but the effects were not obvious, and the ulcer area became larger and deeper.
[0042] The patient began using the herbal composition of this invention for treatment in August 2022. The specific treatment method was as follows: rinsing the wound with saline solution, washing the wound with mulberry leaf water, and applying mulberry leaf powder to the wound and surrounding area. The dressing was changed daily for the first week, and then every two days thereafter. After more than a month, the wound became much smaller and shallower. The patient used the medication at home (first washing the wound with mulberry leaf water using a medical cotton swab, then applying the mulberry leaf powder). [Image of Zhang's diabetic foot treated with mulberry leaf powder is shown.] Figures 4-6 As shown.
[0043] Case 2 Ms. Wang, 40 years old. On June 10, 2023, she received a neck wrinkle treatment at a beauty salon, which resulted in redness, swelling, and ulceration on her neck. Initially, she did not pay attention to it, but it worsened two days later, with the ulcer area increasing and her developing a fever. Intravenous treatment at a local clinic did not improve her condition. On the 9th day, her temperature rose to 39.5℃, and she was treated with the traditional Chinese medicine composition of this invention.
[0044] After diagnosis, Mr. Wang was found to have type 2 diabetes. He was treated with the herbal composition of this invention, and the treatment method was as follows: the wound was rinsed with saline solution, mulberry leaf water was used to clean the wound, and charred Phellodendron bark powder was applied to the wound and surrounding area. The dressing was changed daily for the first five days. On the third day, the wound shrank, new tissue grew, and his temperature was measured at 36.2℃. After improvement, the charred Phellodendron bark powder was used, and the dressing was changed every two days until healed.
[0045] Combination Figures 7-9 It can be seen that the treatment effect on Wang was as follows: the ulcer surface healed after treatment.
[0046] Case 3 Ms. Chao, female, 60 years old. She underwent surgery for breast cancer in June 2023 and was diagnosed with diabetes during her hospitalization. She took hypoglycemic medication while in the hospital. Her surgical incision healed 12 days after surgery, and she was discharged. After discharge, she did not take her hypoglycemic medication as prescribed. A month later, the incision began to ooze fluid, turned white, and eventually completely dehiscenced. The patient sought treatment at a local clinic multiple times, but without effect, and her condition worsened.
[0047] Later, during treatment at our hospital, his blood sugar level was 16 mmol / L. We prescribed hypoglycemic drugs to control his blood sugar and used the traditional Chinese medicine composition of this invention to treat him. The method was as follows: We packed deep ulcers with dressing strips soaked in mulberry leaf water (to lower blood sugar). When there was edema around the superficial wound, we sprinkled mulberry leaf powder around the wound. After sprinkling the mulberry leaf powder, we covered the entire wound with a dressing with a thin layer of medical cotton on one side and secured it with medical tape. When edema was significant, we changed the dressing once a day; after the swelling subsided, we changed the dressing every 2-3 days, or adjusted the frequency of dressing changes according to the condition of the wound. Figures 10-12 It is known that the wound healed after using the mulberry leaf water and mulberry leaf powder of the present invention for more than two months.
[0048] Case 4 Mr. Feng, male, 56 years old, accidentally abraded the skin on the inside of his left leg down to his ankle in October 2021. The abrasion was about 0.5 cm in diameter. The area enlarged the next day, and pus began to ooze from the third day. The patient did not pay attention to it. As time went on, the wound became larger and deeper, and his entire lower leg turned dark red. He then sought medical treatment everywhere and received treatment for more than a year, but his condition did not improve.
[0049] Later, at our hospital, the diagnosis was varicose veins. The herbal composition of this invention was used to treat Mr. Feng, as follows: First, the wound was rinsed with saline solution, then mulberry leaf water was used to clean the wound, mulberry leaf powder was sprinkled on the wound surface, and charcoal powder of Phellodendron bark was applied to the entire lower leg. The area was then covered and bandaged, which promotes blood circulation and facilitates wound healing. The ankle wound was dressed and changed continuously for the first four days. By the fourth dressing change, the wound had significantly improved, with no purulent exudate. Dressings were changed every two to three days thereafter, and the dressing was removed after ten days. The ankle wound was dressed every four to five days depending on the healing progress until it healed completely. By the twenty-eighth day, the wound had healed, and the skin was smooth with no hyperplasia. Before and after treatment photos are shown below. Figure 13 and Figure 14 As shown.
[0050] In addition to the four typical cases mentioned above, more than 30 other patients achieved a cure in a relatively short period of time by using this combination of traditional Chinese medicine formulas.
[0051] Without the herbal composition of this invention, the treatment of ulcers caused by various reasons in diabetic patients is limited to systemic blood sugar control, with no local antibacterial or hypoglycemic drugs available. Ulcer treatment is very limited, with no special treatment other than simple disinfection.
[0052] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.
Claims
1. A traditional Chinese medicine composition, characterized in that, The traditional Chinese medicine composition includes mulberry leaf water and a second component; the second component includes mulberry leaf powder and / or phellodendron bark powder; all components are packaged separately. The method for preparing mulberry leaf powder includes the following steps: charring mulberry leaves, pulverizing them, and obtaining mulberry leaf powder; The preparation method of the Phellodendron bark powder includes the following steps: calcining Phellodendron bark and pulverizing it to obtain Phellodendron bark powder; The method for preparing mulberry leaf water includes the following steps: mixing mulberry leaves and water, boiling, filtering, and obtaining mulberry leaf water.
2. The traditional Chinese medicine composition according to claim 1, characterized in that, The charcoal roasting process includes heating from 180°C to 200°C and roasting for 20-40 minutes.
3. The traditional Chinese medicine composition according to claim 1, characterized in that, The calcination includes: calcining at 160~170℃ for 30~40 min, calcining at 220℃ for 20~30 min, and calcining at 270℃ for 15~20 min; or the calcination includes: calcining at room temperature to 600℃ for 60~80 h.
4. The traditional Chinese medicine composition according to claim 1, characterized in that, The volume of water is 3 to 4 times that of the mulberry leaves; the decoction time is 10 to 15 minutes.
5. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: Mulberry leaves are charred and then crushed to obtain mulberry leaf powder; Phellodendron bark is calcined and pulverized to obtain phellodendron bark powder; Mix mulberry leaves and water, boil, and filter to obtain mulberry leaf water.
6. The traditional Chinese medicine composition according to claim 5, characterized in that, The charcoal roasting process includes heating from 180°C to 200°C and roasting for 20-40 minutes.
7. The traditional Chinese medicine composition according to claim 5, characterized in that, The calcination includes: calcining at 160~170℃ for 30~40 min, calcining at 220℃ for 20~30 min, and calcining at 270℃ for 15~20 min; or the calcination includes: calcining at room temperature to 600℃ for 60~80 h.
8. The traditional Chinese medicine composition according to claim 5, characterized in that, The volume of water is 3 to 4 times that of the mulberry leaves; the decoction time is 10 to 15 minutes.
9. A traditional Chinese medicine preparation, characterized in that, The traditional Chinese medicine preparation includes mulberry leaf water or the traditional Chinese medicine composition according to any one of claims 1 to 4 or the traditional Chinese medicine composition prepared by the preparation method according to any one of claims 5 to 8 and pharmaceutically acceptable excipients; the preparation method of the mulberry leaf water includes the following steps: mixing mulberry leaves and water, decocting, filtering, and obtaining mulberry leaf water.
10. The use of mulberry leaf water or the traditional Chinese medicine composition according to any one of claims 1 to 4 or the traditional Chinese medicine composition prepared by the preparation method according to any one of claims 5 to 8 in the preparation of a medicament for treating diabetic skin ulcers; the preparation method of the mulberry leaf water includes the following steps: Mix mulberry leaves and water, boil, and filter to obtain mulberry leaf water.