Traditional Chinese medicine composition with soothing and anti-inflammatory effects

Abstract

The invention relates to a traditional Chinese medicine composition with soothing and anti-inflammatory effects. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of honeysuckle, 5-35 parts of lalang grass rhizome, 5-35 parts of reed rhizome, 1-30 parts of lotus leaf, 1-30 parts of mulberry leaf, 1-25 parts of lily, 1-25 parts of ginseng leaf and 1-25 parts of rhodiola rosea. The traditional Chinese medicine composition disclosed by the invention combines clearing and tonifying, combines purgation and tonifying, has strong anti-inflammatory, excellent relieving and barrier repairing effects and anti-oxidation effects, is suitable for physique of people mixed with deficiency and excess, and is not easy to generate the side effects that the healthy qi is injured when heat is cleared and the spleen is obstructed when yin is nourished.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine, specifically to a traditional Chinese medicine composition with soothing and anti-inflammatory effects. Background Technology

[0002] Modern environmental stress, lifestyle, and improper skincare habits can easily damage the skin barrier, triggering a series of inflammatory reactions, manifesting as sensitivity, redness, burning, stinging, dryness, and acne. Currently, most topical anti-inflammatory products on the market contain chemical anti-inflammatory ingredients (such as antibiotics, hormones, and nonsteroidal anti-inflammatory drugs) or single plant extracts. The former carries the risk of side effects with long-term use, while the latter often offers only limited efficacy, treating the symptoms but not the root cause, and lacks overall skin barrier repair function. Therefore, a multi-target, comprehensive, safe, and gentle natural solution is needed that can quickly soothe inflammation, address the root cause of skin problems, and promote barrier self-repair.

[0003] Traditional Chinese medicine (TCM) theory holds that skin inflammation often stems from "blood heat," "heat accumulation in the lungs and stomach," or "damp-heat invasion." Treatment typically involves single Chinese herbs and herbal formulas that clear heat and cool the blood, strengthen the spleen and eliminate dampness, promote blood circulation and remove blood stasis, dispel wind and moisten dryness, and replenish qi and blood. Treatment is mainly divided into external and internal methods based on the administration route. External TCM therapy is an important component of traditional clinical medicine, with a broad scope. It refers to the prevention and treatment of diseases by applying medication, physical stimulation, or surgery to the skin, meridians, acupoints, muscles, and bones. Depending on the location of the disease and the progression of the illness, different formulations of medication are prepared, and medication is administered through methods such as acupuncture, fumigation, poultices, plasters, umbilical therapy, physical therapy, and hot baths. External TCM therapy is favored by clinicians due to its ease of operation and low cost, involving numerous dosage forms. Traditional dosage forms mainly include oils, ointments, powders, decoctions, and mixed medications, while newer formulations include sprays and gels. Currently, the quality of topical preparations containing traditional Chinese medicine ingredients on the market varies greatly, and their long-term safety is unclear. Therefore, there is an urgent need to develop a topical preparation that is clinically safe and effective, has few side effects, is suitable for long-term use, and has good anti-inflammatory effects. Summary of the Invention

[0004] To solve the above-mentioned technical problems, the present invention includes the following aspects: The first aspect of the present invention provides a traditional Chinese medicine composition with anti-inflammatory effects, the traditional Chinese medicine composition being prepared from honeysuckle, Imperata cylindrica root, Phragmites communis root, lotus leaf, mulberry leaf, lily, ginseng leaf and Rhodiola rosea.

[0005] Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: honeysuckle 5-35 parts by weight, Imperata cylindrica root 5-35 parts by weight, reed rhizome 5-35 parts by weight, lotus leaf 1-30 parts by weight, mulberry leaf 1-30 parts by weight, lily bulb 1-25 parts by weight, ginseng leaf 1-25 parts by weight, and Rhodiola rosea 1-25 parts by weight.

[0006] More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10-30 parts honeysuckle, 10-30 parts Imperata cylindrica root, 10-30 parts reed rhizome, 5-25 parts lotus leaf, 5-25 parts mulberry leaf, 1-20 parts lily bulb, 1-20 parts ginseng leaf, and 1-20 parts Rhodiola rosea.

[0007] More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 15-25 parts honeysuckle, 15-25 parts Imperata cylindrica root, 15-25 parts reed rhizome, 10-20 parts lotus leaf, 10-20 parts mulberry leaf, 5-15 parts lily bulb, 5-15 parts ginseng leaf, and 5-15 parts Rhodiola rosea.

[0008] Most preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 20 parts honeysuckle, 20 parts Imperata cylindrica root, 20 parts reed rhizome, 15 parts lotus leaf, 15 parts mulberry leaf, 10 parts lily bulb, 10 parts ginseng leaf, and 10 parts Rhodiola rosea.

[0009] Preferably, the traditional Chinese medicine composition further includes pharmaceutically or cosmetically acceptable excipients.

[0010] Preferably, the traditional Chinese medicine composition is a topical preparation.

[0011] Preferably, the dosage form of the traditional Chinese medicine composition is a gel, lotion, patch, ointment, emulsion, face cream, serum, spray, facial mask, wet compress, shower gel, or shampoo. More preferably, the dosage form of the traditional Chinese medicine composition is a gel or lotion.

[0012] The second aspect of the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, the method comprising the following steps: taking the prescribed amounts of honeysuckle, Imperata cylindrica root, Phragmites communis root, lotus leaf, mulberry leaf, lily bulb, ginseng leaf and Rhodiola rosea, grinding each herb into fine powder, mixing and stirring evenly, then adding 4-6 times the amount of water, extracting for 1 hour, adding another 4-6 times the amount of water to the filtered residue, extracting for 1 hour, filtering, combining the two filtrates, concentrating to a traditional Chinese medicine extract with a relative density of 1.1 at 60°C, and optionally adding pharmaceutically or cosmetically acceptable excipients to obtain the final product.

[0013] Preferably, in the preparation method, five times the amount of water is added for extraction twice.

[0014] Preferably, in the preparation method, after the traditional Chinese medicine extract is prepared, carbomer 940 is swollen with deionized water to prepare a gel matrix; the carbomer gel matrix is ​​then taken and the above-mentioned traditional Chinese medicine extract, glycerin, dipotassium glycyrrhizate and p-hydroxyacetophenone are added in sequence, stirred evenly, and the pH of the preparation is adjusted to neutral with an appropriate amount of triethanolamine to obtain the final product.

[0015] Preferably, in the preparation method, after preparing the traditional Chinese medicine extract, carbomer 940 is swollen with deionized water to prepare a gel matrix with a concentration of 0.5-2%; 50-100g of carbomer gel matrix is ​​taken, and 10-30g of the above-mentioned traditional Chinese medicine extract, 2-10g of glycerol, 0.2-1g of dipotassium glycyrrhizate and 0.2-1g of p-hydroxyacetophenone are added in sequence, stirred evenly, and the pH of the preparation is adjusted to neutral with an appropriate amount of triethanolamine to obtain the final product.

[0016] Preferably, in the preparation method, after preparing the traditional Chinese medicine extract, carbomer 940 is swollen with deionized water to prepare a gel matrix with a concentration of 1%; 74g of carbomer gel matrix is ​​taken, and 20g of the above-mentioned traditional Chinese medicine extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate and 0.5g of p-hydroxyacetophenone are added in sequence, stirred evenly, and the pH of the preparation is adjusted to neutral with an appropriate amount of triethanolamine to obtain the final product.

[0017] A third aspect of the present invention provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicament for treating inflammatory skin diseases.

[0018] Preferably, the inflammatory skin disease is selected from sensitive skin, contact dermatitis, atopic dermatitis, photodermatitis, acne, or impaired skin barrier.

[0019] More preferably, the inflammatory skin disease is atopic dermatitis or acne.

[0020] More preferably, the inflammatory skin disease is acne.

[0021] More preferably, the inflammatory skin disease is rosacea.

[0022] The common pharmacological effects of the traditional Chinese medicine raw materials selected in this invention in this field are as follows: Honeysuckle: Cold in nature, sweet in taste, and enters the lung, heart, and stomach meridians. Honeysuckle clears heat and detoxifies, cools and disperses wind-heat, and is used to treat pharyngitis, pulmonary tuberculosis complicated by respiratory tract infection, pneumonia and bacterial dysentery, surgical purulent infection, cervical erosion, and acute ophthalmic inflammation.

[0023] Imperata cylindrica root: It is cold in nature and sweet in taste, and enters the lung, stomach, and bladder meridians. Imperata cylindrica root cools the blood and stops bleeding, clears heat and promotes diuresis. It is used to treat hematemesis, epistaxis, hematuria, fever with thirst, jaundice, edema, painful urination due to heat, and edema due to acute nephritis. It also has the effects of diuresis, promoting blood clotting, and increasing immune function.

[0024] Reed rhizome: It is cold in nature and sweet in taste, and enters the lung and stomach meridians. Reed rhizome clears heat and generates fluids, relieves irritability, stops vomiting, and promotes urination. It is used to treat feverish thirst, vomiting due to stomach heat, cough due to lung heat, lung abscess with purulent sputum, and painful urination due to heat.

[0025] Lotus leaf: It is neutral in nature and bitter and astringent in taste. It enters the heart, liver, and spleen meridians. Lotus leaf clears heat and relieves summer heat, promotes the upward movement of clear yang, cools the blood and stops bleeding. It is used for summer heat and thirst, summer dampness diarrhea, spleen deficiency diarrhea, blood heat vomiting and nosebleeds, hematochezia and metrorrhagia.

[0026] Mulberry leaves: Cold in nature, sweet and bitter in taste, and enter the lung and liver meridians. Mulberry leaves have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, clearing the liver and improving eyesight. They can treat wind-heat colds, dry coughs due to lung heat, dizziness, headaches, and red, blurred vision. Pharmacological studies suggest that mulberry leaves have the effects of clearing the lungs and moistening dryness, relieving coughs, reducing heat, resolving phlegm, relieving headaches, lowering blood sugar, and combating diabetes.

[0027] Lily bulb: It is cold in nature and sweet in taste, and enters the heart and lung meridians. Lily bulb nourishes yin and moistens the lungs, clears the heart and calms the mind. It is used for dry cough due to yin deficiency, cough with blood due to overwork, restlessness and palpitations, insomnia and dreaminess, and mental confusion.

[0028] Ginseng leaves: cold in nature, bitter and sweet in taste, and enter the lung and stomach meridians. Ginseng leaves replenish qi, benefit the lungs, relieve summer heat, and promote the production of body fluids. They are used for cough due to qi deficiency, irritability due to summer heat, thirst due to fluid depletion, blurred vision, and fatigue of the limbs.

[0029] Rhodiola rosea: It is neutral in nature, sweet and bitter in taste, and enters the lung and heart meridians. Rhodiola rosea invigorates qi and blood, unblocks the meridians and relieves asthma. It is used to treat qi deficiency and blood stasis, chest pain, stroke hemiplegia, fatigue and shortness of breath.

[0030] This invention employs a multi-target, systemic conditioning "combination punch" strategy in its herbal composition. Honeysuckle, mulberry leaf, and lotus leaf clear heat and toxins, disperse wind-heat, and cool the blood; lily bulb, reed rhizome, and imperata root are sweet and cold, generating fluids and nourishing yin and moistening the lungs; ginseng leaf and rhodiola rosea invigorate qi and generate fluids, improving microcirculation. The entire formula combines clearing and tonifying, containing both "clearing" herbs like honeysuckle and mulberry leaf, and "tonifying" herbs like ginseng leaf and rhodiola rosea, achieving a balance of attack and tonification. It is particularly suitable for individuals with mixed deficiency and excess constitutions, and is less likely to produce the side effects of "clearing heat damaging the body's vital energy, or nourishing yin hindering the spleen."

[0031] The technical effects of this invention are as follows: 1. Based on extensive screening experiments, this invention has obtained a traditional Chinese medicine composition with potent anti-inflammatory, excellent soothing, barrier-repairing, and antioxidant effects through the optimization of the components and proportions of the traditional Chinese medicine. Honeysuckle, mulberry leaf, and lotus leaf synergistically inhibit inflammatory factors, rapidly reducing redness and swelling; lily, Imperata cylindrica root, and reed rhizome are rich in polysaccharides and mucilage, which can form a protective film on the skin surface, reducing burning and stinging sensations; ginseng leaf and Rhodiola rosea promote the proliferation of keratinocytes and increase the content of skin moisturizing factors, thereby repairing damaged physical and immune barriers. Furthermore, Rhodiola rosea, mulberry leaf, and honeysuckle can also jointly scavenge free radicals, reduce oxidative stress damage, and delay photoaging of the skin.

[0032] 2. This invention combines "clearing heat and purging fire" (honeysuckle, lotus leaf, mulberry leaf) with "tonifying qi and nourishing yin" (ginseng leaf, rhodiola rosea). It treats the symptoms externally while also regulating the internal system. It prevents the problem from recurring by enhancing the skin's own resistance and repair ability, which reflects the wisdom of traditional Chinese medicine of "treating both the symptoms and the root cause".

[0033] 3. All the Chinese herbal raw materials of this invention are natural medicinal and edible plants, which are mild and non-irritating, avoiding the potential side effects of chemical anti-inflammatory ingredients, and are suitable for long-term care of people with sensitive skin. Detailed Implementation

[0034] Example 1 Take 20g of honeysuckle, 20g of Imperata cylindrica root, 20g of reed rhizome, 15g of lotus leaf, 15g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Swell Carbomer 940 with deionized water to prepare a 1% gel matrix. Take 74g of the carbomer gel matrix, add 20g of the above herbal extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate, and 0.5g of p-hydroxyacetophenone, stir evenly, and adjust the pH of the preparation to neutral with an appropriate amount of triethanolamine to obtain the herbal gel preparation 1 of this invention.

[0035] Example 2 Take 10g of honeysuckle, 10g of Imperata cylindrica root, 10g of Phragmites communis root, 15g of lotus leaf, 15g of mulberry leaf, 20g of lily bulb, 20g of ginseng leaf, and 20g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Swell Carbomer 940 with deionized water to prepare a 1% gel matrix. Take 74g of the carbomer gel matrix, add 20g of the above herbal extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate, and 0.5g of p-hydroxyacetophenone, stir evenly, and adjust the pH of the preparation to neutral with an appropriate amount of triethanolamine to obtain the herbal gel preparation 2 of this invention.

[0036] Example 3 Take 10g of honeysuckle, 10g of Imperata cylindrica root, 10g of reed rhizome, 30g of lotus leaf, 30g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Swell Carbomer 940 with deionized water to prepare a 1% gel matrix. Take 74g of the carbomer gel matrix, add 20g of the above herbal extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate, and 0.5g of p-hydroxyacetophenone, stir evenly, and adjust the pH of the preparation to neutral with an appropriate amount of triethanolamine to obtain the herbal gel preparation 3 of this invention.

[0037] Example 4 Take 20g of honeysuckle, 20g of Imperata cylindrica root, 20g of Phragmites communis root, 15g of lotus leaf, 15g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to 100mL of decoction to obtain the herbal wash of this invention.

[0038] Example 5 Take 20g of honeysuckle, 20g of Imperata cylindrica root, 20g of Phragmites communis root, 15g of lotus leaf, 15g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Add 15g of the above herbal extract, 5g of butylene glycol, 0.5g of sodium hyaluronate, and 2g of panthenol sequentially to 77.5g of deionized water, and homogenize and emulsify to obtain the herbal essence of this invention.

[0039] Comparative Example 1 (Honeysuckle was replaced with wild chrysanthemum) Take 20g of wild chrysanthemum, 20g of Imperata cylindrica root, 20g of Phragmites communis root, 15g of lotus leaf, 15g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Swell Carbomer 940 with deionized water to prepare a 1% gel matrix. Take 74g of the carbomer gel matrix, add 20g of the above herbal extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate, and 0.5g of p-hydroxyacetophenone, stir evenly, and adjust the pH of the preparation to neutral with an appropriate amount of triethanolamine to obtain the herbal gel preparation, Comparative Example 1.

[0040] Comparative Example 2 (Reed rhizome replaced with Lophatherum gracile leaves) Take 20g of honeysuckle, 20g of Imperata cylindrica root, 20g of Lophatherum gracile leaves, 15g of lotus leaf, 15g of mulberry leaf, 10g of lily bulb, 10g of ginseng leaf, and 10g of Rhodiola rosea. Grind each ingredient into a fine powder, mix and stir evenly, then add 600g of distilled water and extract for 1 hour. After filtration, add another 600g of distilled water to the residue and extract for 1 hour. Filter again, combine the two filtrates, and concentrate to a herbal extract with a relative density of 1.1 at 60℃. Swell Carbomer 940 with deionized water to prepare a 1% gel matrix. Take 74g of the carbomer gel matrix, add 20g of the above herbal extract, 5g of glycerin, 0.5g of dipotassium glycyrrhizate, and 0.5g of p-hydroxyacetophenone, stir evenly, and adjust the pH of the preparation to neutral with an appropriate amount of triethanolamine to obtain the herbal gel preparation (Comparative Example 2).

[0041] Experimental Example 1: The therapeutic effect of the herbal gel of the present invention on atopic dermatitis model mice. 1. Test Methods Prepare a 1 nmol / L solution of MC903 in anhydrous ethanol and store at −20℃ protected from light. Take 30±2 g of (8-10 week old) female clean-grade Kunming mice and apply 15 μL of the 1 nmol / L MC903 solution to the skin of the ears (dorsal and ventral sides) once daily for 8 consecutive days. Mice exhibiting ear skin edema, capillary dilation and congestion, accompanied by obvious erythema and a small amount of desquamation are considered successfully induced AD model mice.

[0042] Sixty successfully modeled Alzheimer's disease (AD) mice were randomly divided into six experimental groups: the model group, the groups of Examples 1-3 of this invention, and the comparative examples 1-2, with ten mice in each group. Ten normal mice without modeling were used as the control group. The mice in the Examples 1-3 and Comparative examples 1-2 had the gel prepared in those groups applied to the affected skin daily at a dose of 50 mg / kg body weight. The control and model groups had the same dose of a gel without traditional Chinese medicine components (made from 94 g of carbomer gel matrix, 5 g of glycerin, 0.5 g of dipotassium glycyrrhizate, and 0.5 g of p-hydroxyacetophenone, with the pH adjusted to neutral by an appropriate amount of triethanolamine) applied twice daily for four consecutive weeks. Twenty-four hours after the last administration, the mice were enucleated and blood was collected. The blood was allowed to coagulate naturally at room temperature for 10-20 minutes, then centrifuged at 2500 r / min for 20 minutes. The serum was collected and the levels of the inflammatory factors interleukin-4 (IL-4) and interleukin-6 (IL-6) in the serum of mice in each experimental group were detected by enzyme-linked immunosorbent assay (ELISA).

[0043] 2. Test Results The levels of IL-4 and IL-6 in the serum of mice in each experimental group after administration of the traditional Chinese medicine gel of the present invention are shown in Table 1.

[0044] Table 1 Comparison of serum IL-4 and IL-6 levels in mice from different experimental groups As shown in Table 1 above, compared with the normal group of mice, the serum levels of IL-4 and IL-6 in the model group of mice were significantly increased. Compared with the model group and the control groups 1-2, the serum levels of IL-4 and IL-6 in the experimental groups treated with the herbal gel 1-3 of this invention were significantly decreased (p<0.05). The above experimental results confirm that the herbal gel of this invention can effectively reduce the level of inflammatory factors in serum, and is expected to be effective in the clinical treatment of patients with atopic dermatitis.

[0045] Experimental Example 2: Clinical therapeutic effect of the traditional Chinese medicine composition of the present invention on patients with rosacea. 1. Test Methods Thirty patients with rosacea meeting the criteria were recruited at the Dermatology Clinic of Ningbo Municipal Hospital of Traditional Chinese Medicine. Using a random number table, 30 subjects were randomly divided into a basic intervention group (Group A) and a traditional Chinese medicine intervention group (Group B), with 15 subjects in each group. Subjects in the basic intervention group received guidance on skin barrier repair: all patients received standardized skin care education, including daily use of a gentle amino acid cleanser, morning and evening use of a designated hypoallergenic moisturizer, and daytime use of a broad-spectrum sunscreen with SPF30+ / PA+++. Subjects in the traditional Chinese medicine intervention group, in addition to the skin barrier repair guidance provided to the basic intervention group, further received 100mL of the traditional Chinese medicine decoction prepared in Example 4 of this invention for cold compresses on the face, once daily for 20 minutes each time, for four consecutive weeks. Referring to the criteria of the American Rosacea Expert Committee, the four categories of rosacea symptoms were scored on the subjects in the two experimental groups before and after the intervention, as follows: ①C (telangiectasia); ②P (papules and pustules); ③E (persistent erythema); ④F (paroxysmal flushing). Each symptom was scored from 0 to 3 (0=none, 1=mild, 2=moderate, 3=severe), with a total score range of 0-12. The scores of the above four categories of symptoms for the subjects in each experimental group were counted and the total score was calculated.

[0046] 2. Test Results Table 2 Comparison of symptom scores and total scores before and after intervention in the two experimental groups (n=15) Note: Paired t-tests are used for within-group comparisons of p-values, and independent samples t-tests are used for between-group comparisons of p-values ​​(comparing changes).

[0047] As shown in Table 2 above, in the basic intervention group (Group A), the score for telangiectasia (C) remained unchanged before and after the intervention. Papules and pustules (P) and persistent erythema (E) all showed significant improvement (p<0.01), while the improvement trend for paroxysmal flushing (F) was not statistically significant (p=0.334). The total score decreased from 8.60 to 7.73, showing significant improvement (p<0.001). In contrast, in the traditional Chinese medicine intervention group (Group B), all individual symptom scores and the total score showed extremely significant decreases after intervention (p<0.001), with the total score decreasing significantly from 8.60 to 5.20, indicating that the traditional Chinese medicine of this invention has a comprehensive and significant improvement effect on various symptoms of rosacea. Furthermore, the intergroup efficacy comparison analysis showed a significant difference in the degree of symptom improvement between the two experimental groups. The traditional Chinese medicine intervention group (Group B) showed significantly better improvement in all four symptom items and the total score than the basic intervention group (Group A), and the difference was highly statistically significant.

[0048] The above experimental results show that the traditional Chinese medicine composition of the present invention has a significant effect in the clinical treatment of rosacea, especially in controlling "paroxysmal flushing" and improving "telangiectasia" symptoms.

[0049] Although specific embodiments of the invention have been described, those skilled in the art will recognize that various changes and modifications can be made to the invention without departing from its scope or spirit. Therefore, the invention is intended to cover all such changes and modifications falling within the scope of the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition having a soothing and anti-inflammatory effect, characterized in that, The traditional Chinese medicine composition is prepared from honeysuckle, Imperata cylindrica root, Phragmites communis root, lotus leaf, mulberry leaf, lily, ginseng leaf and Rhodiola rosea.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: honeysuckle 5-35 parts by weight, Imperata cylindrica root 5-35 parts by weight, Phragmites communis root 5-35 parts by weight, lotus leaf 1-30 parts by weight, mulberry leaf 1-30 parts by weight, lily bulb 1-25 parts by weight, ginseng leaf 1-25 parts by weight, and Rhodiola rosea 1-25 parts by weight.

3. The traditional Chinese medicine composition according to claim 2, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10-30 parts honeysuckle, 10-30 parts Imperata cylindrica root, 10-30 parts reed rhizome, 5-25 parts lotus leaf, 5-25 parts mulberry leaf, 1-20 parts lily bulb, 1-20 parts ginseng leaf, and 1-20 parts Rhodiola rosea.

4. The traditional Chinese medicine composition according to claim 3, characterized in that, Honeysuckle 15-25 parts by weight, Imperata cylindrica root 15-25 parts by weight, Phragmites communis root 15-25 parts by weight, Lotus leaf 10-20 parts by weight, Mulberry leaf 10-20 parts by weight, Lily bulb 5-15 parts by weight, Ginseng leaf 5-15 parts by weight, Rhodiola rosea 5-15 parts by weight.

5. The traditional Chinese medicine composition according to claim 4, characterized in that, The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 20 parts honeysuckle, 20 parts Imperata cylindrica root, 20 parts reed rhizome, 15 parts lotus leaf, 15 parts mulberry leaf, 10 parts lily bulb, 10 parts ginseng leaf, and 10 parts Rhodiola rosea.

6. The traditional Chinese medicine composition according to any one of claims 1-5, characterized in that, The traditional Chinese medicine composition further includes pharmaceutically acceptable excipients.

7. The traditional Chinese medicine composition according to any one of claims 1-5, characterized in that, The traditional Chinese medicine composition is a topical preparation.

8. The traditional Chinese medicine composition according to claim 7, characterized in that, The dosage forms of the traditional Chinese medicine composition are gels, lotions, patches, ointments, lotions, creams, serums, sprays, masks, wet compresses, shower gels, and shampoos.

9. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-8, characterized in that, The preparation method includes the following steps: take the prescribed amounts of honeysuckle, Imperata cylindrica root, Phragmites communis root, lotus leaf, mulberry leaf, lily bulb, ginseng leaf, and Rhodiola rosea, grind each herb into a fine powder, mix and stir evenly, then add 4-6 times the amount of water, extract for 1 hour, add another 4-6 times the amount of water to the filtered residue, extract for 1 hour, filter, combine the two filtrates, concentrate to a herbal extract with a relative density of 1.1 at 60℃, and optionally add pharmaceutically or cosmetically acceptable excipients to obtain the final product.

10. The use of the traditional Chinese medicine composition according to any one of claims 1-8 in the preparation of a medicament for treating inflammatory skin diseases.

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