Atomization drug delivery equipment for targeted pulmonary delivery of icariin

Abstract

The invention relates to the technical field of medical atomization, and discloses an icariin targeted lung delivery atomization drug delivery device which comprises an atomization main machine and an air guide pipe arranged on the atomization main machine, an atomization cup is arranged at the end, away from the atomization main machine, of the air guide pipe, a mask is fixed to the upper portion of the atomization cup, and the device further comprises an atomization piece and a drug delivery device. The nozzle is fixed at the bottom in the atomizing cup; the screening piece is fixed at the top in the atomizing cup; the seepage piece is fixed in the atomizing cup; an atomizing liquid plate is fixed at the bottom in the atomizing cup, a seepage plate is fixed at the middle position in the atomizing cup, and a permeable plate is fixed at the top in the atomizing cup; the vortex box is fixed below the atomized liquid plate; through collaborative design of airflow driving and the structure, precise screening of target particles of 1-5 microns is achieved, in a screening piece, a coarse screening area of a screening drum forms spiral downward stable vortex airflow in the drum by means of tangent airflow introduced by an air distribution pipe, and liquid beads exceeding 5 microns are thrown to the wall of the drum by means of centrifugal force.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical atomization, in particular to an atomization device for targeted lung delivery of icariin. BACKGROUND

[0002] In the clinical treatment of lung diseases, atomization drug delivery is an important drug delivery method because it can directly act on the lesion and reduce systemic side effects. For active ingredients of traditional Chinese medicine such as icariin, which has anti-inflammatory and lung tissue protection effects, atomization delivery to the lung lesion can better exert its therapeutic value. The anatomical structure and airflow dynamics of the lung determine that only 1-5 μm of atomized particles can penetrate the bronchial and bronchiolar barrier and stably deposit in the alveoli or small airways to exert their effects. Particles smaller than 1 μm are easily lost with the exhalation flow due to their weak inertia, and particles larger than 5 μm are easily deposited in the upper respiratory tract such as the throat and trachea due to their strong inertia, and thus cannot reach the lesion. Therefore, precise control of the particle size of the atomized particles is a core prerequisite for targeted lung drug delivery.

[0003] However, the existing medical atomization device has obvious technical shortcomings and cannot meet the needs of targeted delivery of icariin atomization liquid. On the one hand, the existing device lacks a reliable two-stage screening and particle size stabilization mechanism, and the output icariin atomization liquid particle size fluctuation range is large, and cannot be fixed in the 1-5 μm targeted interval. Some devices only use single centrifugation or screen filtration, which easily produces a large number of ultra-fine particles smaller than 1 μm. These particles are quickly expelled with the exhalation flow after passing through the lungs and cannot achieve the desired effect. At the same time, they also contain too many coarse particles larger than 5 μm. These particles are deposited in the upper respiratory tract and cannot act on the lung lesion, and may also cause discomfort such as throat irritation. On the other hand, the existing device is not designed to adapt to the characteristics of traditional Chinese medicine atomization liquid. Icariin is prone to precipitation and stratification in the liquid due to differences in solubility, and the device lacks efficient stirring and uniform liquid supply structure, further leading to uneven concentration and particle size of the atomized particles. The separated unqualified particles are mostly directly discarded without an effective recycling mechanism, causing waste of icariin liquid and difficulty in ensuring the stability of the drug dose, which affects the consistency of the clinical treatment effect. SUMMARY

[0004] The present application provides an atomization drug delivery device for targeted lung delivery of icariin, which can effectively target the delivery of atomized drugs.

[0005] To solve the above technical problems, the technical solution of the present application is as follows: An atomization drug delivery device for targeted lung delivery of icariin, comprising: an atomization host and a gas guide tube arranged on the atomization host, wherein the end of the gas guide tube away from the atomization host is provided with an atomization cup, and the top of the atomization cup is fixed with a face mask, further comprising: an atomization element fixed to the bottom of the atomization cup; a screening element fixed to the top of the atomization cup; and a liquid permeation element fixed in the atomization cup. The bottom of the atomizing cup is fixed with an atomizing liquid plate, the middle of the atomizing cup is fixed with a liquid permeation plate, and the top of the atomizing cup is fixed with a gas permeation plate. The vortex box is fixed below the atomizing liquid plate; the air inlet pipe is fixed at one end on the vortex box and extends out of the atomizing cup at the other end; the rotating drum is rotatably arranged above the atomizing liquid plate; the vortex impeller is rotatably arranged above the rotating drum; the vortex blades are arranged in multiple and are arranged at equal angles below the rotating drum; the atomizing air nozzle is fixedly inserted into the vortex box and extends out of the liquid permeation plate; and the atomizing liquid nozzle is fixed on the liquid permeation plate and located directly above the atomizing air nozzle. The sieve cylinder is fixed on the gas permeation plate; the layering plate is fixed in the sieve cylinder; the gas distribution pipe is inserted into the sieve cylinder at one end and fixed on the atomizing air nozzle at the other end; the atomizing pipe is fixed on the atomizing cup at the top and inserted into the atomizing cup at the bottom; the atomizing inlet cylinder is fixed above the sieve cylinder and sleeved on the atomizing pipe; the multi-hole plate is fixed on the layering plate; the inverted cone cylinder is fixed below the layering plate and directly below the multi-hole plate; and the collection cover is fixed at the bottom of the sieve cylinder and directly below the atomizing pipe.

[0006] Further, the atomizing cup is provided with a liquid storage area between the atomizing liquid plate and the liquid permeation plate; the atomizing cup is provided with an atomizing area between the liquid permeation plate and the gas permeation plate; and the top of the atomizing cup is provided with a sieve atomizing area above the gas permeation plate.

[0007] Further, the atomizing part further comprises: The air inlet groove is arranged below the atomizing air nozzle; the suction pipe is fixed on the atomizing liquid nozzle at the top; the liquid suction box is fixed below the suction pipe and at the bottom of the liquid storage area; and the split hole ring is fixed at one end above the atomizing air nozzle and at the other end in the atomizing liquid nozzle.

[0008] Further, the atomizing part further comprises: The misalignment groove is arranged in the atomizing liquid nozzle; the piston ring is vertically slidably arranged in the misalignment groove; the return spring is fixed at one end on the piston ring and at the other end in the misalignment groove; and the sealing rubber ring is fixed in the atomizing liquid nozzle.

[0009] Further, the atomizing part further comprises: The snap ring is fixed outside the atomizing air nozzle; the snap groove is arranged in the atomizing liquid nozzle; and the partition plate is fixed below the gas permeation plate and directly above the atomizing air nozzle and the atomizing liquid nozzle.

[0010] Further, the sieve part further comprises: The coarse sieve area is arranged above the layering plate; the first liquid collecting strip-shaped groove is arranged on the inner wall of the sieve cylinder; the first liquid collecting annular groove is arranged on the inner wall of the sieve cylinder; and the first concave hole is arranged in the sieve cylinder and communicates with the first liquid collecting annular groove.

[0011] Furthermore, the screening component also includes: The second sieve section is located below the stratification plate; the second liquid collection strip groove is located on the inner wall of the sieve cylinder; the second liquid collection annular groove is located at the bottom of the sieve cylinder; and the second concave hole is located inside the sieve cylinder and is connected to the second liquid collection strip groove.

[0012] Furthermore, the leakage element includes: The seepage tube is fixed to the seepage plate; the sealing ring is fixed inside the seepage tube; the annular seat is fixed inside the seepage tube and located above the sealing ring; the float is slidably disposed between the sealing ring and the annular seat; and the floating spring is fixed at one end to the annular seat and at the other end to the float.

[0013] Furthermore, the breathable plate has eight breathable holes arranged at equal angles.

[0014] Furthermore, a connecting pipe is fixed to the top of the atomizing cup, and the end of the connecting pipe away from the atomizing cup is inserted into the air hole of the mask; a handle is fixed to the outside of the atomizing cup, and a liquid cap is fixed to the outside of the atomizing cup.

[0015] The above-described solution of the present invention has at least the following beneficial effects: This invention achieves precise screening of 1-5μm targeted particles through the coordinated design of airflow drive and structure: In the screening component, the coarse screening zone of the screening cylinder relies on the tangential airflow introduced by the air distribution pipe to form a stable downward spiral vortex airflow inside the cylinder. Centrifugal force throws droplets larger than 5μm towards the cylinder wall. These droplets flow along the cylinder wall into the first liquid collection strip groove, are collected in the first liquid collection annular groove, and then return through the first concave hole. Simultaneously, a porous plate with a 5μm pore size intercepts a small number of large particles that were not separated by the vortex, forming a dual coarse screening process combining airflow centrifugal force and structural interception; after entering the fine screening zone... The inverted cone accelerates the airflow a second time through a constricted channel, amplifying the inertial difference between 1-5μm and smaller than 1μm particles. The 1.5-2 times diameter gap between the outlet of the inverted cone and the collecting hood provides precise space for airflow diffusion and inertial separation. Liquid droplets smaller than 1μm diffuse away with the accelerated airflow, while 1-5μm droplets break through the airflow diffusion constraint due to inertia and enter the collecting hood. Guided by the curved surface of the collecting hood, they flow into the atomizing tube and are then stably delivered through the connecting pipe and the mask. The entire process is centered on airflow movement and relies on the adaptation and cooperation of various structures to achieve efficient retention of targeted particles.

[0016] This invention improves the utilization efficiency of the drug solution and ensures a stable drug concentration. Through the synergistic effect of the atomizing components: the rotation of the vortex impeller in the liquid storage area stirs the atomized liquid to prevent the precipitation and stratification of icariin components, ensuring a consistent drug concentration for each atomization. It can also push residual drug solution to the suction box through centrifugal force, reducing waste. The reflux design of the first liquid collection annular groove and the liquid storage area allows large liquid droplets that have been screened out to re-participate in atomization, further improving the utilization rate of the drug solution. Attached Figure Description

[0017] Figure 1 A schematic diagram of the overall structure of a nebulized drug delivery device for targeted lung delivery of icariin, provided in an embodiment of the present invention; Figure 2 A schematic diagram of the nebulizer cup structure of a nebulized drug delivery device for targeted lung delivery of icariin is provided in an embodiment of the present invention; Figure 3 A schematic diagram of the air duct structure of a nebulized drug delivery device for targeted lung delivery of icariin, provided in an embodiment of the present invention; Figure 4 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 3 Enlarged view of point A; Figure 5 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 3 Enlarged view of point B; Figure 6 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 3 Enlarged view of point C; Figure 7 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 3 Enlarged view of point D; Figure 8 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 3 Enlarged view of point E; Figure 9 A schematic diagram of the sieving cylinder structure of a nebulized drug delivery device for targeted lung delivery of icariin, provided in an embodiment of the present invention; Figure 10 A schematic diagram of an inverted cone structure for a nebulized drug delivery device for targeted lung delivery of icariin, provided in an embodiment of the present invention; Figure 11 This invention provides an embodiment of an nebulized drug delivery device for targeted lung delivery of icariin. Figure 10 Enlarged view at point F; Figure 12A schematic diagram of the rotary drum structure of a nebulized drug delivery device for targeted lung delivery of icariin is provided in an embodiment of the present invention; Figure 13 This is a schematic diagram of the nebulizer nozzle structure of a nebulized drug delivery device for targeted lung delivery of icariin, provided in an embodiment of the present invention.

[0018] Explanation of reference numerals in the attached figures: In the diagram: 1. Atomizing main unit; 2. Air guide tube; 3. Atomizing cup; 301. Atomizing liquid plate; 302. Liquid seepage plate; 303. Air vent plate; 304. Liquid storage area; 305. Atomizing area; 306. Atomizing mist sieving area; 307. Air vent; 4. Face mask; 5. Atomizing components; 501. Vortex box; 502. Air inlet pipe; 503. Rotary drum; 504. Vortex impeller; 505. Vortex blades; 506. Atomizing air nozzle; 507. Atomizing liquid nozzle; 508. Air inlet slot; 509. Suction pipe; 5010. Liquid suction box; 5011. Dividing ring; 5012. Misalignment groove; 5013. Piston ring; 5014. Return spring; 5015. Sealing rubber ring; 5016. Snap ring; 5017. 5018. Slot; 6. Partition plate; 601. Sieve component; 602. Sieve cylinder; 603. Layering plate; 604. Gas distribution pipe; 605. Atomizing pipe; 606. Atomizing inlet cylinder; 607. Perforated plate; 608. Inverted cone cylinder; 609. Collection hood; 6010. Coarse sieving area; 6010. First liquid collection strip groove; 6011. First liquid collection annular groove; 6012. First concave hole; 6013. Fine sieving area; 6014. Second liquid collection strip groove; 6015. Second liquid collection annular groove; 6016. Second concave hole; 7. Leakage component; 701. Leakage pipe; 702. Sealing ring; 703. Annular seat; 704. Float ball; 705. Floating spring; 8. Connecting pipe; 9. Handle; 10. Liquid cover. Detailed Implementation

[0019] Exemplary embodiments of the invention will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the invention are shown in the drawings, it should be understood that the invention may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this invention will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

[0020] like Figures 1 to 13 As shown, an embodiment of the present invention provides a nebulized drug delivery device for targeted lung delivery of icariin, comprising: a nebulizer 1 and an air delivery tube 2 disposed on the nebulizer 1, wherein an nebulizer cup 3 is disposed at the end of the air delivery tube 2 away from the nebulizer 1, and a mask 4 is fixed above the nebulizer cup 3, and further comprising: Atomizing component 5 is fixed to the bottom of atomizing cup 3; sieve component 6 is fixed to the top of atomizing cup 3; seepage component 7 is fixed inside atomizing cup 3; an atomizing liquid plate 301 is fixed to the bottom of atomizing cup 3, a seepage plate 302 is fixed to the middle of atomizing cup 3, and a breathable plate 303 is fixed to the top of atomizing cup 3; a vortex box 501 is fixed below the atomizing liquid plate 301; an air inlet pipe 502 is fixed at one end to the vortex box 501 and extends out of atomizing cup 3; a rotating cylinder 503 is rotatably mounted on the atomizing liquid plate 301; a vortex impeller 504 is rotatably mounted above the rotating cylinder 503; multiple vortex blades 505 are provided, and the multiple vortex blades 505 are evenly positioned below the rotating cylinder 503; an atomizing nozzle 506 is fixedly inserted into the vortex box 501 at the bottom and extends out of the top. The system comprises: a seepage plate 302; an atomizing nozzle 507 fixed to the seepage plate 302 at the bottom and located directly above the atomizing nozzle 506; a sieve cylinder 601 fixed to the venting plate 303; a layering plate 602 fixed inside the sieve cylinder 601; a gas distribution pipe 603, one end of which is inserted into the top of the sieve cylinder 601 and the other end fixed to the atomizing nozzle 506; an atomizing tube 604 fixed to the top of the atomizing cup 3 and inserted into the bottom of the atomizing cup 3; an atomizing inlet cylinder 605 fixed above the sieve cylinder 601 and fitted onto the atomizing tube 604; a perforated plate 606 fixed to the layering plate 602; an inverted cone 607 fixed below the layering plate 602 and located directly below the perforated plate 606; and a collecting hood 608 fixed at the bottom of the sieve cylinder 601 and located directly below the atomizing tube 604.

[0021] The atomizing cup 3 has a liquid storage area 304 located between the atomizing liquid plate 301 and the seepage plate 302; the atomizing cup 3 has an atomizing area 305 located between the seepage plate 302 and the air permeable plate 303; and the top of the atomizing cup 3 has a mist sieving area 306 located above the air permeable plate 303.

[0022] The vent plate 303 has eight vent holes 307 arranged at equal angles. A connecting pipe 8 is fixed to the top of the atomizing cup 3, with the end of the connecting pipe 8 furthest from the atomizing cup 3 inserted into the air vent of the mask 4. A handle 9 and a liquid cap 10 are fixed to the outside of the atomizing cup 3. Specifically, the pore size of the porous plate 606 is precisely matched to the 5μm screening threshold, which can trap a small number of liquid droplets larger than 5μm that have not been separated by the vortex airflow, further improving the coarse screening effect; the inner walls of the screening cylinder 601, atomizing tube 604, atomizing inlet cylinder 605, inverted cone cylinder 607, collecting hood 608 and connecting pipe 8 are all treated with a medical-grade hydrophobic coating for hydrophobic surface treatment.

[0023] In another preferred embodiment of the present invention, the atomizing component 5 further includes: an air inlet groove 508, which is formed below the atomizing nozzle 506; a suction tube 509, which is fixed above the atomizing liquid nozzle 507; a liquid suction box 5010, which is fixed below the suction tube 509 and located at the bottom of the liquid storage area; and a hole ring 5011, which is fixed at one end above the atomizing nozzle 506 and at the other end inside the atomizing liquid nozzle 507.

[0024] The atomizing component 5 also includes: a misalignment groove 5012, which is formed in the atomizing nozzle 507; a piston ring 5013, which is vertically slidably disposed in the misalignment groove 5012; a return spring 5014, one end of which is fixed on the piston ring 5013 and the other end of which is fixed in the misalignment groove 5012; and a sealing rubber ring 5015, which is fixed in the atomizing nozzle 507.

[0025] The atomizing component 5 also includes: a retaining ring 5016, fixed on the outside of the atomizing nozzle 506; a retaining groove 5017, opened inside the atomizing liquid nozzle 507; and a partition 5018, fixed below the vent plate 303 and located directly above the atomizing nozzle 506 and the atomizing liquid nozzle 507.

[0026] Specifically, the suction tube 509 and the suction box 5010 can draw atomized liquid; the dividing ring 5011 is used to divide the atomized liquid; the return spring 5014 has low elasticity, which facilitates the piston ring 5013 to move upward under negative pressure; the sealing rubber ring 5015 is used for sealing to prevent gas or liquid leakage; the retaining ring 5016 and the retaining groove 5017 are snapped together, thereby connecting the atomizing air nozzle 506 and the atomizing liquid nozzle 507.

[0027] In another preferred embodiment of the present invention, the sieving component 6 further includes: a coarse sieving region 609, which is formed above the layering plate 602; a first liquid collecting strip groove 6010, which is formed on the inner wall of the sieving cylinder 601; a first liquid collecting annular groove 6011, which is formed on the inner wall of the sieving cylinder 601; and a first concave hole 6012, which is formed inside the sieving cylinder 601 and communicates with the first liquid collecting annular groove 6011.

[0028] The sieving component 6 further includes: a fine sieving area 6013, located below the stratification plate 602; a second liquid collecting strip groove 6014, located on the inner wall of the sieving cylinder 601; a second liquid collecting annular groove 6015, located at the bottom of the sieving cylinder 601; and a second concave hole 6016, located inside the sieving cylinder 601 and connected to the second liquid collecting strip groove 6014.

[0029] Specifically, both the first liquid collecting strip 6010 and the second liquid collecting strip 6014 are vertically arranged.

[0030] In another preferred embodiment of the present invention, the seepage component 7 includes: a seepage pipe 701 fixed on the seepage plate 302; a sealing ring 702 fixed inside the seepage pipe 701; an annular seat 703 fixed inside the seepage pipe 701 and located above the sealing ring 702; a float 704 slidably disposed between the sealing ring 702 and the annular seat 703; and a floating spring 705, one end of which is fixed on the annular seat 703 and the other end of which is fixed on the float 704.

[0031] The atomizing cup 3 in this invention must be manufactured and assembled in a professional production workshop. Users are strictly prohibited from assembling it themselves. Non-professional assembly can easily lead to misalignment of parts and reduced sealing performance, which will ultimately greatly reduce the sieving effect of the atomizing cup 3 and make it impossible to guarantee the accuracy of the targeted particles. The atomizing host 1 is equipped with an air compressor to provide a stable airflow for the atomization process. The air inlet of the atomizing host 1 is specially equipped with a filter, which can effectively filter out dust, impurities and microorganisms in the air, prevent such pollutants from entering the subsequent airflow channel, prevent the atomizing liquid from being contaminated and block the atomizing nozzle 506, and ensure the stable operation and safe use of this equipment. Working principle: First, open the liquid cap 10 and inject the medical nebulizer liquid containing icariin into the nebulizer cup 3, ensuring that the liquid level of the nebulizer liquid is within the reasonable range of the liquid storage area 304. Then close the liquid cap 10 to ensure the airtightness of the nebulizer cup 3. Start the nebulizer host 1, and the device enters the nebulization working state. The user holds the nebulizer cup 3 from the handle 9. The compressed airflow generated by the atomizing host 1 is delivered to the air inlet pipe 502 through the air guide pipe 2, and then enters the vortex box 501 through the air inlet pipe 502. After the airflow enters the vortex box 501, it will directly act on the vortex blades 505, pushing the vortex blades 505 to drive the rotating cylinder 503 to rotate around its own axis. The rotation of the rotating cylinder 503 will synchronously drive the vortex impeller 504 above to rotate. At the same time, as the airflow pushes the vortex blades 505, it will flow smoothly along the arc surface of the vortex blades 505 and enter the air inlet slot 508. Through the air inlet slot 508, it will quickly enter the atomizing nozzle 506 and spray out a high-speed airflow from the outlet end of the atomizing nozzle 506. The liquid atomizer nozzle 507 is fitted onto the outside of the air atomizer nozzle 506, forming a narrow gap between them. When a high-speed airflow passes through this narrow gap, a negative pressure is generated inside according to Bernoulli's principle. When the negative pressure reaches a set threshold, an upward suction force is generated, pulling the piston ring 5013 upward. This causes the piston ring 5013 to overcome the elastic force of the return spring 5014, which in turn compresses. After moving upward, the piston ring 5013 retracts into the misalignment groove 5012, no longer blocking the gap between the air atomizer nozzle 506 and the liquid atomizer nozzle 507. Since the gap is connected to the suction tube 509 and the liquid suction box 5010, the negative pressure inside the gap is transmitted to the suction tube 509 and the liquid suction box 5010 through the connecting channel, ensuring that both the suction tube 509 and the liquid suction box 5010 are under negative pressure, thus preparing for the adsorption of the atomized liquid. The vortex impeller 504 is located within the liquid storage area 304. During its rotation, the vortex impeller 504 thoroughly stirs the atomized liquid in the liquid storage area 304. This not only effectively prevents the precipitation or stratification of components such as icariin in the atomized liquid, ensuring a consistent aerosol drug concentration for each atomization, but also guarantees a stable dose of aerosol drug in each breath inhaled by the user. At the same time, the rotation of the vortex impeller 504 generates centrifugal force, pushing the atomized liquid between the impeller blades towards the opening of the suction box 5010. Even when the remaining amount of atomized liquid is low, the residual liquid can be pushed towards the opening, minimizing liquid waste. Under negative pressure, the atomizing liquid enters the suction box 5010, and is then drawn from the suction box 5010 into the distribution pipe 509. It flows along the distribution pipe 509 to the gap between the atomizing air nozzle 506 and the atomizing liquid nozzle 507, and then flows out through the channels of the dividing ring 5011. The channels of the dividing ring 5011 disperse the atomizing liquid into fine streams, which mix more thoroughly with the high-speed airflow. The mixed atomizing liquid and high-speed airflow are ejected from the common nozzle of the atomizing air nozzle 506 and the atomizing liquid nozzle 507, directly impacting the septum 5018. The obstruction effect further breaks down the droplets in the mixed airflow, forming extremely small mist droplets; larger droplets, due to their greater mass and stronger inertia, will impact the inner wall of the atomizing cup 3 in the atomizing area 305 under the force of ejection, and then flow back along the inner wall to the inner bottom of the atomizing area 305 to re-participate in the atomization process; smaller droplets, due to their smaller mass and weaker inertia, will not impact the inner wall of the atomizing cup 3 in the atomizing area 305, but will mix with the airflow to form an atomized airflow, which will enter the sieving mist area 306 through the vent holes 307 on the vent plate 303. The atomized airflow entering the sieving mist zone 306 first passes through the atomizing inlet cylinder 605, which initially converges the atomized airflow to prevent airflow diffusion and reduce sieving efficiency. The atomized airflow then enters the coarse sieving zone 609 inside the sieving cylinder 601. The coarse sieving zone 609 uses vortex airflow to sieve droplets larger than 5μm in the atomized airflow: the lower end of the air distribution pipe 603 is connected to the atomizing nozzle 506, from which a portion of the high-speed airflow is separated. The upper end of the air distribution pipe 603 cuts into the inner top of the coarse sieving zone 609 at a tangential angle. After entering, this portion of the airflow spirals downwards along the inner wall of the sieving cylinder 601, forming a stable vortex. The atomized airflow flows downwards from directly above the coarse sieving area 609. Driven by the vortex airflow, it gradually merges into the vortex airflow. As the vortex airflow spirals downwards, it generates centrifugal force, throwing droplets larger than 5μm in the atomized airflow toward the inner wall of the sieving cylinder 601. The droplets thrown onto the inner wall flow along the inner wall and enter the first liquid collecting strip groove 6010, which guides the droplets to flow quickly toward the first liquid collecting annular groove 6011. The droplets converge into atomized liquid in the first liquid collecting annular groove 6011 and flow out of the sieving cylinder 601 through the first concave hole 6012. The outflowing atomized liquid eventually flows back to the liquid storage area 304, realizing the recycling of the liquid. After the atomized airflow that has removed droplets larger than 5μm through coarse sieving, it will enter the fine sieving area 6013 of the sieving cylinder 601 through the porous plate 606. The pore size of the porous plate 606 is precisely matched to the 5μm sieving threshold, which can retain a small number of droplets larger than 5μm that have not been separated by the vortex airflow, further improving the coarse sieving effect. The atomized airflow through the perforated plate 606 directly enters the interior of the inverted cone 607. The inner diameter of the inverted cone 607 gradually narrows from the inlet to the outlet. The dispersed atomized airflow is converged and accelerated a second time through the contraction channel, causing the airflow to be ejected towards the collecting hood 608 in the form of a high-speed jet. The atomized airflow enters the fine screening area 6013. A certain gap is left between the outlet end of the inverted cone 607 and the opening end of the collecting hood 608. The gap is set to 1.5-2 times the diameter of the outlet end of the inverted cone 607. This gap provides sufficient space for the inertial separation of particles: after the atomized airflow is ejected from the outlet end of the inverted cone 607, liquid droplets smaller than 1μm will diffuse outward with the airflow due to their small mass and weak inertia; while liquid droplets of 1-5μm, due to their large mass and strong inertia, can overcome the diffusion force of the airflow and directly enter the interior of the collecting hood 608 by inertia. The inner wall of the collecting cover 608 has a curved structure, which can guide the incoming atomized airflow and allow the airflow to smoothly enter the inner bottom of the atomizing tube 604. The curved surface of the collecting cover 608 is treated with a medical-grade hydrophobic coating, which can significantly reduce the adhesion of atomizing liquid on the curved surface, effectively reduce water accumulation, and avoid blocking the airflow channel or affecting the concentration of atomized particles due to water accumulation. The atomized airflow entering the bottom of the atomizing tube 604 flows upward along the tube. The inner wall of the atomizing tube 604 is smoothed to reduce airflow resistance and particle deposition. It then flows into the connecting tube 8 and then into the mask 4. The connecting tube 8 also has a smooth inner wall design to ensure stable delivery of the atomized airflow, which is ultimately inhaled by the user. At this time, the droplet size in the atomized airflow is stable within the range of 1-5μm, which can achieve targeted lung delivery of icariin.

[0032] Liquid droplets smaller than 1 μm adhere to the inner wall of the sieve cylinder 601 in the fine sieve area 6013. The atomized liquid is collected in the second liquid collecting strip groove 6014, flows into the second liquid collecting annular groove 6015, and then flows out of the sieve cylinder 601 through the second concave hole 6016. The atomized liquid flows to the inner bottom of the atomization area 305. The atomized liquid enters the seepage pipe 701. When the atomized liquid accumulates in the seepage pipe 701, it floats the float ball 704. The liquid then flows back into the liquid storage area 304 through the gap between the float ball 704 and the floating closed ring 702.

[0033] This invention achieves precise screening of 1-5μm targeted particles through the coordinated design of airflow drive and structure: In the screening component 6, the coarse screening area 609 of the screening cylinder 601 relies on the high-speed airflow introduced at a tangential angle by the air distribution pipe 603 to form a stable spiral downward vortex airflow inside the cylinder; the vortex airflow can continuously generate uniform centrifugal force, efficiently throwing large liquid droplets larger than 5μm in the atomized airflow toward the cylinder wall; these large liquid droplets flow naturally along the cylinder wall and enter the specially designed first liquid collection strip groove 6010, and then are collected into liquid state through the first liquid collection annular groove 6011, and flow back to the liquid storage area 304 through the first concave hole 6012; the porous plate 606 located below the coarse screening area 609, with a pore size precisely matched to 5μm, intercepts a small number of large particles that are not completely separated by the vortex airflow, forming a double coarse screening of airflow centrifugal separation and structural pore size interception, further preventing large particles from entering the subsequent process; The atomized airflow flows out from the porous plate 606 and enters the fine sieve area 6013. The atomized airflow is converged and accelerated a second time through the gradually narrowing inner diameter channel of the inverted cone 607, allowing the airflow to be ejected in a more stable high-speed jet form, effectively amplifying the inertial difference between 1-5μm target particles and ultrafine particles smaller than 1μm. The 1.5-2 times diameter gap between the outlet of the inverted cone 607 and the collecting hood 608 provides sufficient space for particle inertial separation. Due to their weak inertia, ultrafine particles smaller than 1μm adhere to the inner wall of the sieve cylinder 601 after being diffused by the accelerated airflow, while the 1-5μm target particles, with their strong inertia, break through the airflow diffusion constraint and enter the collecting hood 608. Guided by its curved surface, they smoothly flow into the atomizing tube 604, and are then stably delivered to the user's respiratory tract through the connecting tube 8 and the mask 4. The entire process is centered on airflow movement, relying on the adaptation and cooperation of various structures to achieve efficient retention of targeted particles.

[0034] This invention improves the utilization efficiency of the drug solution and ensures a stable drug concentration. This effect is achieved through the synergistic effect of the atomizing component 5: When the vortex impeller 504 located in the liquid storage area 304 rotates with the rotating drum 503, on the one hand, the blades stir the atomized liquid, allowing the icariin component to be evenly dispersed in the liquid, avoiding local concentrations that are too high or too low due to sedimentation and stratification, ensuring that the aerosol drug concentration generated by each atomization is consistent, thereby ensuring a stable inhaled dose for the user; on the other hand, the centrifugal force generated by the rotation of the impeller can push the atomized liquid between the blades and in the corners of the liquid storage area 304 toward the opening of the suction box 5010, reducing residue at the bottom of the cup even if the remaining amount of atomized liquid is small, minimizing drug waste; large liquid droplets trapped during the coarse sieving process can re-participate in the atomization process after flowing back to the liquid storage area 304 through the first liquid collecting annular groove 6011 and the first concave hole 6012, instead of being directly discarded, further improving the overall utilization rate of the drug solution.

[0035] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A nebulized drug delivery device for targeted lung delivery of icariin, comprising: The atomizing unit and the air guide tube disposed on the atomizing unit, wherein an atomizing cup is disposed at the end of the air guide tube away from the atomizing unit, and a face mask is fixed above the atomizing cup, characterized in that it further includes: The atomizing component is fixed to the bottom of the atomizing cup; the sieving component is fixed to the top of the atomizing cup; and the seepage component is fixed inside the atomizing cup. An atomizing liquid plate is fixed at the bottom of the atomizing cup, a seepage plate is fixed at the middle of the atomizing cup, and a breathable plate is fixed at the top of the atomizing cup. A vortex box is fixed below the atomizing liquid plate; an air inlet pipe is fixed at one end to the vortex box and extends out to the atomizing cup at the other end; a rotating cylinder is rotatably mounted on the atomizing liquid plate; a vortex impeller is rotatably mounted above the rotating cylinder; multiple vortex blades are provided, and the multiple vortex blades are arranged at equal angles below the rotating cylinder; an atomizing nozzle is fixedly inserted into the vortex box at the bottom and extends out to the seepage plate at the top; an atomizing liquid nozzle is fixedly mounted on the seepage plate at the bottom and is located directly above the atomizing air nozzle; The sieving cylinder is fixed to the air permeable plate; the layering plate is fixed inside the sieving cylinder; the air distribution pipe is inserted at one end above the sieving cylinder and at the other end fixed to the atomizing nozzle; the atomizing tube is fixed at the top of the atomizing cup and inserted into the atomizing cup at the bottom; the atomizing inlet cylinder is fixed above the sieving cylinder and fitted onto the atomizing tube; the perforated plate is fixed to the layering plate; the inverted cone is fixed below the layering plate and located directly below the perforated plate; and the collecting hood is fixed at the bottom inside the sieving cylinder and located directly below the atomizing tube.

2. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The atomizing cup has a liquid storage area located between the atomizing liquid plate and the seepage plate; the atomizing cup has an atomizing area located between the seepage plate and the air permeable plate; and the top of the atomizing cup has a mist sieving area located above the air permeable plate.

3. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The atomizing element also includes: An air inlet slot is located below the atomizing nozzle; a suction tube is fixed above the liquid atomizing nozzle; a liquid collection box is fixed below the suction tube and located at the bottom of the liquid storage area; and a distribution ring is fixed at one end above the atomizing nozzle and at the other end inside the liquid atomizing nozzle.

4. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 3, characterized in that, The atomizing element also includes: The misalignment groove is formed inside the atomizing nozzle; the piston ring is vertically slidably set in the misalignment groove; the return spring is fixed at one end to the piston ring and at the other end to the misalignment groove; the sealing rubber ring is fixed inside the atomizing nozzle.

5. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 4, characterized in that, The atomizing element also includes: A retaining ring is fixed to the outside of the atomizing nozzle; a retaining groove is formed inside the atomizing liquid nozzle; a partition is fixed below the vent plate and located directly above the atomizing nozzle and the atomizing liquid nozzle.

6. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The screening component further includes: The coarse sieving area is located above the stratification plate; the first liquid collection strip groove is located on the inner wall of the sieving cylinder; the first liquid collection annular groove is located on the inner wall of the sieving cylinder; and the first concave hole is located inside the sieving cylinder and is connected to the first liquid collection annular groove.

7. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 6, characterized in that, The screening component further includes: The second sieve section is located below the stratification plate; the second liquid collection strip groove is located on the inner wall of the sieve cylinder; the second liquid collection annular groove is located at the bottom of the sieve cylinder; and the second concave hole is located inside the sieve cylinder and is connected to the second liquid collection strip groove.

8. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The leakage component includes: The seepage tube is fixed to the seepage plate; the sealing ring is fixed inside the seepage tube; the annular seat is fixed inside the seepage tube and located above the sealing ring; the float is slidably disposed between the sealing ring and the annular seat; and the floating spring is fixed at one end to the annular seat and at the other end to the float.

9. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The breathable plate has eight air holes arranged at equal angles.

10. The nebulized drug delivery device for targeted lung delivery of icariin according to claim 1, characterized in that, The top of the atomizing cup is fixed with a connecting pipe, and the end of the connecting pipe away from the atomizing cup is inserted into the air hole of the mask; a handle is fixed to the outside of the atomizing cup, and a liquid cap is fixed to the outside of the atomizing cup.

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