Angle-adjustable interventional biopsy needle suitable for deep tumor and sampling method of angle-adjustable interventional biopsy needle

Abstract

The invention discloses an angle-adjustable interventional biopsy needle suitable for deep tumors and a sampling method of the angle-adjustable interventional biopsy needle, and relates to the field of tumor interventional biopsy sampling, the angle-adjustable interventional biopsy needle comprises a guide sheathing canal, the guide sheathing canal is composed of an outer sheath layer on the outermost layer, a braid layer in the middle and a first lining layer on the inner layer, and a bending mechanism is arranged at the bottom of the guide sheathing canal; the bending mechanism comprises an active bending tube, the active bending tube is fixedly connected with the bottom of the guiding sheath tube, a protection pad is arranged at the bottom of the active bending tube, and a second lining layer is arranged on the inner side of the active bending tube. On the premise of single puncture, multi-point and multi-angle sampling of different quadrants and different depths in a tumor can be easily achieved, representative tissue samples can be obtained to the maximum extent through the design, sampling errors caused by tumor heterogeneity are effectively avoided, the occurrence rate of false negative results is remarkably reduced, and the sampling efficiency is improved. And a more reliable pathological basis is provided for clinical diagnosis.

Description

Technical Field

[0001] This invention belongs to the field of interventional tumor biopsy sampling, specifically an adjustable-angle interventional biopsy needle and its sampling method suitable for deep tumors. Background Technology

[0002] Percutaneous biopsy is a key technique for diagnosing the nature of deep tumors in the body. It provides a decisive basis for the pathological diagnosis, grading, molecular subtyping, and subsequent treatment planning of malignant tumors. This technique is usually performed under the guidance of medical imaging equipment such as ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI).

[0003] Currently, the percutaneous biopsy technique widely used in clinical practice mainly relies on coaxial puncture technology. This technique first inserts a relatively thick guide needle (or guide sheath) to the edge of the tumor, and then inserts a traditional straight biopsy needle through the working channel of the guide needle to obtain a tissue sample.

[0004] However, if the traditional coaxial puncture technique requires multiple sampling points in different areas of the tumor, the doctor must completely withdraw the straight guide needle and biopsy needle, manually change the angle, and then perform the puncture again. This process not only prolongs the operation time and increases the radiation exposure of doctors and patients under radiation guidance, but also significantly increases the risk of complications such as bleeding, pneumothorax, and seed metastasis with multiple punctures, bringing additional pain and safety burden to patients.

[0005] To address these issues, those skilled in the art have proposed an adjustable-angle interventional biopsy needle and its sampling method suitable for deep tumors. Summary of the Invention

[0006] The purpose of this invention is to provide an adjustable-angle interventional biopsy needle and its sampling method suitable for deep tumors, in order to solve the problem that in the prior art, if multiple sampling is required for different areas of the tumor, the doctor must completely withdraw the straight guide needle and biopsy needle, manually change the angle and re-puncture. This process not only prolongs the operation time and increases the radiation exposure of doctors and patients under radiation guidance, but also significantly increases the risk of complications such as bleeding, pneumothorax, and implantation metastasis with multiple punctures, bringing additional pain and safety burden to patients.

[0007] To achieve the above objectives, the present invention provides the following technical solution: an adjustable-angle interventional biopsy needle suitable for deep tumors and its sampling method, comprising a guide sheath, the guide sheath being composed of an outermost outer sheath layer, a middle braided layer, and an inner first liner layer; a bending mechanism is provided at the bottom of the guide sheath, the bending mechanism including an active bending tube fixedly connected to the bottom of the guide sheath; a protective pad is provided at the bottom of the active bending tube; a second liner layer is provided on the inner side of the active bending tube; the end of the protective pad away from the active bending tube is rounded; four guide cavities are provided on the sidewall of the active bending tube, and four guide cavities are also provided on the sidewall of the guide sheath. Each guide cavity of the active bending tube corresponds to and matches the position of each guide cavity of the guide sheath. A guide tube is provided at the top of the guide cavity of the guide sheath, and a traction wire is provided inside the guide cavity. The front end of the traction wire is fixedly connected to the bottom of the guide cavity of the active bending tube, and the rear end of the traction wire passes through the guide cavity and guide tube of the guide sheath and extends to the outside of the guide sheath. An external operating mechanism is provided at the rear end of the traction wire. A puncture mechanism is provided inside both the active bending tube and the guide sheath. The puncture mechanism includes a flexible biopsy needle core. The flexible biopsy needle core passes through the active bending tube and the guide sheath. A sampling component is provided at one end of the flexible biopsy needle core that passes through the active bending tube.

[0008] Preferably, the outer sheath is made of polyurethane to provide the integrity of the overall structure and to contact human tissue; the braided layer is woven from nickel-titanium alloy filaments to resist compression and transmit torque; and both the first and second inner liner layers are made of polytetrafluoroethylene to form a low-friction working channel to ensure that the flexible biopsy needle core can pass smoothly.

[0009] Preferably, the flexible biopsy needle core is an ultra-thin and long flexible rod, specifically made of a super-elastic nickel-iron alloy, and the traction wire is made of Kevlar fiber.

[0010] Preferably, the sampling assembly includes a sampling slot, which is formed on the side wall of one end of the flexible biopsy needle core that passes through the active bending tube, and sampling blades are provided on all four side walls of the sampling slot.

[0011] Preferably, the external operating mechanism includes a housing, and a control component is disposed inside the housing, the number of which is the same as the number of traction lines.

[0012] Preferably, the control component includes a fixing plate located inside the housing. A winding wheel is disposed above the fixing plate, and a first rotating block is disposed at the bottom of the winding wheel. The top of the first rotating block is fixedly connected to the top of the winding wheel, and the bottom of the first rotating block is rotatably connected to the fixing plate. The winding wheel is connected to a traction line. A second rotating block is disposed at the top of the winding wheel, and the second rotating block is fixedly connected to the winding wheel. The top of the second rotating block passes through the housing and extends to the outside of the housing, and the second rotating block is rotatably connected to the housing.

[0013] Preferably, the second rotating block is provided with a dial wheel on its top, and a scale groove is provided on the surface of the outer shell below the dial wheel. A connecting rod is fixedly connected to the lower surface of the dial wheel, and a pointer is fixedly connected to the bottom of the connecting rod. An angle scale is provided on the surface of the scale groove.

[0014] A sampling method for an adjustable-angle interventional biopsy needle suitable for deep tumors includes the following steps:

[0015] S1. Perform a preoperative scan on the patient to determine the location, size, and relationship of the tumor to surrounding critical organs, and plan a safe initial straight path that passes through healthy tissue as far as possible and avoids all important structures. Perform routine disinfection and anesthesia on the puncture site, and then use a standard guide needle to puncture near the target area to establish a channel, and then remove the guide needle.

[0016] S2. Insert the initial state of the guide sheath along the channel established by the introduction needle, so that its distal end reaches the predetermined position outside the tumor edge. By rotating the dial, the dial drives the first rotating block to rotate, and the rotation of the first rotating block drives the winding wheel to rotate, so that the winding wheel winds up the traction line, thereby slowly and accurately adjusting the bending angle and direction of the active bending tube at the end of the traction line, so that its tip is aligned with the specific target area of ​​the tumor. This process is carried out under real-time CT scan monitoring to ensure accurate and safe angle adjustment.

[0017] S3. Keeping the angle and position of the guide sheath unchanged, push the flexible biopsy needle core forward through the working channel of the guide sheath. The flexible biopsy needle core will advance along the preset curved path of the guide sheath, and its tip will eventually reach the target tissue precisely. After the image confirms that the needle tip position is correct, the sampling groove opens and is embedded in the tissue. At this time, rotate the needle core to cut off the tissue sample in the groove and seal it in the groove. Withdraw the needle core with the sample taken from the sheath and collect the sample.

[0018] S4. When multiple sampling points are required, there is no need to move the guide sheath. Simply change the bending angle of the sheath and / or rotate the direction of the sheath by slightly changing the external operating mechanism to define a completely new path for the needle core. Insert a new or debrided biopsy needle core and repeat S3 to obtain a second and third sample from another area of ​​the tumor. This process can be repeated multiple times to achieve efficient and accurate sampling of different parts of the tumor.

[0019] S5. After all sampling is completed, adjust the bending angle of the guide sheath back to the initial straight state, smoothly withdraw the entire system from the patient's body, and apply pressure to the puncture site for hemostasis and treatment.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] 1. When the angle of the flexible biopsy needle core needs to be changed, this invention rotates a dial wheel, which drives a first rotating block to rotate. The rotation of the first rotating block drives a winding wheel to rotate, causing the winding wheel to wind up the traction wire. This allows the angle of the active bending tube to be adjusted at the end of the traction wire. Through the four traction wires and corresponding control components, the bending direction of the active bending tube can be precisely controlled. The bending angle of the active bending tube can be accurately understood through a pointer and an angle scale. This allows doctors to guide the flexible biopsy needle core to specific suspicious areas of the tumor (such as enhanced areas or areas to avoid necrosis), achieving a leap from "approximate puncture" to "precise targeting." Moreover, it can easily achieve multi-point and multi-angle sampling of different quadrants and depths within the tumor in a single puncture, maximizing the acquisition of representative tissue samples. This effectively avoids sampling errors caused by tumor heterogeneity, significantly reduces the incidence of false negative results, and provides a more reliable pathological basis for clinical diagnosis.

[0022] 2. This invention can first safely advance to the vicinity of the tumor via a straight path, and then "bypass" important structures such as major blood vessels, nerves, and bones by bending the end, successfully reaching lesion areas (such as pancreatic cancer and hepatic hilar tumors) that cannot be safely reached by traditional straight needles. Multiple samples can be obtained with a single puncture, avoiding secondary damage to healthy tissues caused by repeated punctures and needle withdrawal, thereby significantly reducing the risk of complications such as bleeding, infection, and pneumothorax (during lung biopsy). At the same time, doctors no longer need to perform tedious repeated puncture operations to adjust the sampling angle; they only need to adjust the external control mechanism to change the sampling path. This greatly shortens the operation time and improves the turnover efficiency of the operating room. Especially under CT or X-ray guidance, the shortened operation time directly means a significant reduction in the radiation dose received by doctors and patients, improving the health and safety of the surgical environment. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0024] Figure 1 This is a schematic diagram of the guiding sheath and puncture mechanism in this invention;

[0025] Figure 2 This is an exploded view of the guiding sheath and bending mechanism in this invention;

[0026] Figure 3 For the present invention Figure 1 Enlarged view of point A in the middle;

[0027] Figure 4 For the present invention Figure 1 Enlarged view at point B in the middle;

[0028] Figure 5 This is a schematic diagram of the external operating mechanism in this invention;

[0029] Figure 6 This is a cross-sectional view of the external operating mechanism in this invention;

[0030] Figure 7 For the present invention Figure 6 Enlarged view of point C.

[0031] In the picture:

[0032] 1. Guiding sheath; 101. Outer sheath layer; 102. Braided layer; 103. First inner liner layer; 104. Guiding tube; 2. Bending mechanism; 201. Active bending tube; 202. Protective pad; 203. Guide cavity; 204. Second inner liner layer; 3. Traction line; 4. External operating mechanism; 401. Outer shell; 402. Fixing plate; 403. Rewinding wheel; 404. First rotating block; 405. Dial wheel; 406. Second rotating block; 407. Scale groove; 408. Connecting rod; 409. Pointer; 410. Angle scale; 5. Puncture mechanism; 501. Flexible biopsy needle core; 502. Sampling groove; 503. Sampling blade. Detailed Implementation

[0033] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0034] As attached Figure 1 To be continued Figure 7 As shown:

[0035] Example 1: This invention provides an adjustable-angle interventional biopsy needle suitable for deep tumors and its sampling method, including a guide sheath 1. The guide sheath 1 consists of an outermost outer sheath layer 101, a middle braided layer 102, and an inner first inner liner layer 103. A bending mechanism 2 is provided at the bottom of the guide sheath 1. The bending mechanism 2 includes an active bending tube 201, which is made of nickel-titanium alloy. Under external force, it can undergo a large-scale bending deformation, and once the external force is removed, it can completely restore its original shape without permanent plastic deformation. This allows the active bending tube 201 to be bent repeatedly without damage. The active bending tube 201 is fixedly connected to the bottom of the guide sheath 1. A protective pad 202 is provided at the bottom of the active bending tube 201. A second inner liner layer 204 is provided inside the active bending tube (201). The protective pad 202 is located away from the active bending tube. One end of the active bending tube 201 is rounded and blunt. The side wall of the active bending tube 201 is provided with four guide cavities 203, and the side wall of the guide sheath tube 1 is also provided with four guide cavities 203. The positions of each guide cavity 203 of the active bending tube 201 and each guide cavity 203 of the guide sheath tube 1 are matched. A guide tube 104 is provided at the top of the guide cavity 203 of the guide sheath tube 1. A traction line 3 is provided inside the guide cavity 203. The front end of the traction line 3 is fixedly connected to the bottom of the guide cavity 203 of the active bending tube 201. The rear end of the traction line 3 passes through the guide cavity 203 and the guide tube of the guide sheath tube 1 and extends to the outside of the guide sheath tube 1. An external operating mechanism 4 is provided at the rear end of the traction line 3. When the external operating mechanism 4 winds up or releases the traction line 3, the traction line 3 can drive the corresponding part of the active bending tube 201 to deform, thereby realizing the adjustment of the bending angle and direction. The four traction wires 3 correspond to different directions of the active bending tube 201. By controlling the extension and retraction length of different traction wires 3 individually or in combination, the active bending tube 201 can be flexibly bent in any direction to meet the angle requirements for sampling at different locations of the tumor. Both the active bending tube 201 and the guide sheath 1 are equipped with a puncture mechanism 5. The puncture mechanism 5 includes a flexible biopsy needle core 501. The flexible biopsy needle core 501 passes through the active bending tube 201 and the guide sheath 1. A sampling component is provided at one end of the flexible biopsy needle core 501 that passes through the active bending tube 201.

[0036] In one embodiment of the present invention, the outer sheath layer 101 is made of polyurethane, which has excellent biocompatibility and can effectively reduce irritation and rejection reactions when in contact with human tissue. At the same time, its good structural stability can ensure that the sheath maintains its shape during puncture and operation, and avoid damage due to external pressure or tissue friction. The braided layer 102 is made of nickel-titanium alloy filaments. Nickel-titanium alloy has unique superelasticity and shape memory properties. The braided structure further enhances the sheath's resistance to compression. Even when subjected to external impact in a complex internal environment, it can maintain the overall shape of the sheath and prevent the channel from collapsing. Furthermore, the braided layer 102 can efficiently transmit torque. When the doctor adjusts the sheath angle through the external operating mechanism 4, the torque can be precisely transmitted to the bending mechanism 2 at the end through the braided layer 102, ensuring the timeliness and accuracy of angle adjustment. The first inner liner 103 and the second inner liner 204 are both made of polytetrafluoroethylene to form a low-friction working channel, ensuring that the flexible biopsy needle core 501 can pass smoothly. The flexible biopsy needle core 501 is an ultra-slender flexible rod, specifically made of a super-elastic nickel-iron alloy, which can maintain good structural stability in a bent state and is not easy to break or deform. The flexible biopsy needle core 501 is designed as an ultra-slender flexible rod, which can easily adapt to the guide sheath 1 and the active bending. The curved channel formed by the curved tube 201 smoothly reaches the target area of ​​the tumor. Even in complex internal pathways, it can flexibly move around without causing excessive compression or damage to surrounding tissues. The traction line 3 is made of Kevlar fiber, a material known for its high strength and toughness. Its tensile strength far exceeds that of ordinary fiber materials, and it is not easy to break when subjected to large tensile forces. This ensures that the tensile force can be stably transmitted when adjusting the angle of the active curved tube 201, achieving precise angle control. At the same time, Kevlar fiber also has good corrosion resistance and wear resistance. It is not easy to age or break during long-term contact and friction with the guide cavity 203 and the winding wheel 403, ensuring the service life and working stability of the traction line 3.

[0037] In one embodiment of the present invention, the sampling assembly includes a sampling groove 502, which is located on the side wall of one end of the flexible biopsy needle core 501 through the active bending tube 201. Each of the four side walls of the sampling groove 502 is provided with a sampling blade 503. The blade is made of medical-grade high-hardness stainless steel and undergoes special polishing treatment, resulting in a sharp blade with smooth edges. During the sampling process, after the sampling groove 502 is embedded in the tissue, the doctor rotates the needle core, and the blade can quickly and accurately cut the tissue, ensuring neat sample edges and reducing tissue damage. Simultaneously, it can quickly seal the cut tissue sample within the sampling groove 502, preventing sample loss or contamination, ensuring the integrity and purity of the sample, and providing a reliable basis for subsequent pathological diagnosis.

[0038] In one embodiment of the present invention, the external operating mechanism 4 includes a housing 401, inside which a control assembly is disposed. The number of control assemblies is the same as the number of traction lines 3. The control assembly includes a fixing plate 402 located inside the housing 401. A take-up roller 403 is disposed above the fixing plate 402. A first rotating block 404 is disposed at the bottom of the take-up roller 403. The first rotating block 404 adopts a high-precision bearing structure, which reduces friction and increases stability when the take-up roller 403 rotates, ensuring uniform winding and unwinding of the traction line 3 and avoiding sudden changes in speed that could affect the angle adjustment accuracy. The top of the first rotating block 404 is fixedly connected to the top of the take-up roller 403, and the bottom of the first rotating block 404 is rotatably connected to the fixing plate 402. The take-up roller 403 is connected to the traction line 3, and a second rotating block 406 is disposed at the top of the take-up roller 403. The second rotating block 406 is fixedly connected to the winding wheel 403. The top of the second rotating block 406 passes through the outer shell 401 and extends to the outside of the outer shell 401. The second rotating block 406 is rotatably connected to the outer shell 401. A dial wheel 405 is provided on the top of the second rotating block 406. A scale groove 407 is provided on the surface of the outer shell 401 below the dial wheel 405. A connecting rod 408 is fixedly connected to the lower surface of the dial wheel 405. A pointer 409 is fixedly connected to the bottom of the connecting rod 408. An angle scale 410 is provided on the surface of the scale groove 407. When the doctor rotates the dial wheel 405, the pointer 409 will rotate synchronously with the dial wheel 405. The scale indicated by the pointer 409 can intuitively reflect the bending angle of the active bending tube 201, so that the doctor can accurately grasp the angle adjustment and avoid inaccurate sampling position due to angle deviation, which greatly improves the controllability of operation and the accuracy of sampling.

[0039] Working principle: When performing a deep tumor biopsy, the active bending tube 201 is first adjusted to an initial straight state by the external operating mechanism 4, so that the entire biopsy needle forms a smooth straight channel for easy puncture. Then, the doctor holds the external operating mechanism 4 and slowly inserts the whole assembly of the guide sheath 1 and the active bending tube 201 into the patient's body along the preset safe puncture path until the protective pad 202 at the bottom of the active bending tube 201 reaches the predetermined position on the outer side of the tumor edge.

[0040] When the sampling angle needs to be adjusted, the doctor rotates the corresponding dial 405 of the external operating mechanism 4 based on the tumor location and target sampling area displayed in the real-time CT scan. The rotation of the dial 405 drives the second rotating block 406 to rotate, which in turn causes the winding wheel 403 to rotate synchronously. The winding wheel 403 winds up the corresponding traction wire 3. Since the front end of the traction wire 3 is fixedly connected to the active bending tube 201, the traction wire 3 applies tension to the active bending tube 201 during the winding process, causing the active bending tube 201 to bend in the direction of the winding of the traction wire 3. At the same time, the doctor precisely controls the bending angle by observing the direction of the pointer 409 below the dial 405 on the angle scale 410 until the tip of the active bending tube 201 is aligned with the specific target sampling area of ​​the tumor.

[0041] After the angle adjustment is completed, keep the position and angle of the guide sheath 1 and the active bending tube 201 unchanged. The doctor slowly pushes the flexible biopsy needle core 501 forward from the working channel of the guide sheath 1. Due to the low friction channel formed by the first inner liner 103 and the second inner liner 204, and the superelasticity of the flexible biopsy needle core 501 itself, the needle core can move smoothly along the preset bending path until the sampling component reaches the target tissue.

[0042] After the imaging equipment confirms that the needle tip position is correct, the sampling slot 502 opens and is embedded in the tissue. At this time, the doctor rotates the flexible biopsy needle core 501 clockwise or counterclockwise. The blades around the sampling slot 502 quickly cut the tissue, cut off the tissue sample and seal it in the sampling slot 502. Then, the doctor slowly withdraws the flexible biopsy needle core 501 from the sheath and takes out the tissue sample in the sampling slot 502, completing one sampling.

[0043] If multiple sampling is required, there is no need to remove the guide sheath 1 and the active bending tube 201 from the patient's body. Simply adjust the extension and retraction states of different traction lines 3 through the external operating mechanism 4, change the bending angle and direction of the active bending tube 201, and plan a new sampling path for the flexible biopsy needle core 501. Then repeat the above steps of pushing the needle core, sampling, and withdrawing the needle core to obtain multiple tissue samples from different quadrants and depths of the tumor.

[0044] After all sampling is completed, the doctor uses the external operating mechanism 4 to adjust the bending angle of the active bending tube 201 back to its initial straight state, then smoothly withdraws the entire biopsy needle system from the patient's body, and finally applies pressure to the puncture site for hemostasis and disinfection, thus completing the entire biopsy procedure.

[0045] Example 2: A sampling method for an adjustable-angle interventional biopsy needle suitable for deep tumors, comprising the following steps:

[0046] S1. Perform a preoperative scan on the patient to determine the location, size, and relationship of the tumor to surrounding critical organs, and plan a safe initial straight path that passes through healthy tissue as far as possible and avoids all important structures. Perform routine disinfection and anesthesia on the puncture site, and then use a standard guide needle to puncture near the target area to establish a channel, and then remove the guide needle.

[0047] S2. Insert the initial state of the guide sheath 1 along the channel established by the introduction needle, so that its distal end reaches the predetermined position outside the edge of the tumor. By rotating the dial 405, the dial 405 drives the first rotating block 404 to rotate. The rotation of the first rotating block 404 drives the winding wheel 403 to rotate, so that the winding wheel 403 winds up the traction line 3, thereby slowly and accurately adjusting the bending angle and direction of the active bending tube 201 at the end of the traction line 3, so that its tip is aligned with the specific target area of ​​the tumor. This process is carried out under real-time CT scan monitoring to ensure accurate and safe angle adjustment.

[0048] S3. Keeping the angle and position of the guide sheath 1 unchanged, push the flexible biopsy needle core 501 forward through the working channel of the guide sheath 1. The flexible biopsy needle core 501 will advance along the preset curved path of the guide sheath 1, and its needle tip will finally reach the target tissue accurately. After the image confirms that the needle tip position is correct, the sampling groove 502 opens and is embedded in the tissue. At this time, rotate the needle core to cut off the tissue sample in the groove and seal it in the groove. Withdraw the needle core with the sample taken from the sheath and collect the sample.

[0049] S4. When multiple sampling points are required, there is no need to move the guide sheath 1. Simply change the bending angle of the sheath and / or rotate the direction of the sheath by slightly changing the external operating mechanism 4 to define a completely new path for the needle core. Insert a new or debrided biopsy needle core and repeat S3 to obtain a second and third sample from another area of ​​the tumor. This process can be repeated multiple times to achieve efficient and accurate sampling of different parts of the tumor.

[0050] S5. After all sampling is completed, adjust the bending angle of the guide sheath 1 back to the initial straight state, smoothly withdraw the entire system from the patient's body, and apply pressure to the puncture site for hemostasis and treatment.

[0051] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. An adjustable-angle interventional biopsy needle suitable for deep tumors, characterized in that: The system includes a guide sheath (1), which consists of an outermost outer sheath layer (101), a middle braided layer (102), and an inner first inner lining layer (103). A bending mechanism (2) is provided at the bottom of the guide sheath (1). The bending mechanism (2) includes an active bending tube (201), which is fixedly connected to the bottom of the guide sheath (1). A protective pad (202) is provided at the bottom of the active bending tube (201). A second inner lining layer (204) is provided inside the active bending tube (201). The end of the protective pad (202) away from the active bending tube (201) is rounded. Four guide cavities (203) are provided on the sidewall of the active bending tube (201), and four guide cavities (203) are also provided on the sidewall of the guide sheath (1). Each guide cavity (203) of the active bending tube (201) is connected to each guide cavity (103) of the guide sheath (1). The positions of the guide cavity (203) are all matched. A guide tube (104) is provided at the top of the guide cavity (203) of the guide sheath (1). A traction wire (3) is provided inside the guide cavity (203). The front end of the traction wire (3) is fixedly connected to the bottom of the guide cavity (203) of the active bending tube (201). The rear end of the traction wire (3) passes through the guide cavity (203) and the guide tube of the guide sheath (1) and extends to the outside of the guide sheath (1). An external operating mechanism (4) is provided at the rear end of the traction wire (3). A puncture mechanism (5) is provided inside both the active bending tube (201) and the guide sheath (1). The puncture mechanism (5) includes a flexible biopsy needle core (501). The flexible biopsy needle core (501) passes through the active bending tube (201) and the guide sheath (1). A sampling component is provided at one end of the flexible biopsy needle core (501) that passes through the active bending tube (201).

2. The adjustable-angle interventional biopsy needle for deep tumors according to claim 1, characterized in that: The outer sheath (101) is made of polyurethane to provide the integrity of the overall structure and to contact human tissue. The braided layer (102) is made of nickel-titanium alloy filaments to resist compression and transmit torque. The first inner liner (103) and the second inner liner (204) are both made of polytetrafluoroethylene to form a low-friction working channel to ensure that the flexible biopsy needle core (501) can pass through smoothly.

3. The adjustable-angle interventional biopsy needle for deep tumors according to claim 1, characterized in that: The flexible biopsy needle core (501) is an ultra-thin and long flexible rod, specifically made of ultra-elastic nickel-iron alloy, and the traction wire (3) is made of Kevlar fiber.

4. The adjustable-angle interventional biopsy needle for deep tumors according to claim 1, characterized in that: The sampling assembly includes a sampling slot (502), which is located on the side wall of one end of the flexible biopsy needle core (501) through the active bending tube (201). Each of the four side walls of the sampling slot (502) is provided with a sampling blade (503).

5. The adjustable-angle interventional biopsy needle for deep tumors according to claim 1, characterized in that: The external operating mechanism (4) includes a housing (401), and a control component is provided inside the housing (401). The number of the control component is the same as the number of the traction lines (3).

6. The adjustable-angle interventional biopsy needle for deep tumors according to claim 5, characterized in that: The control component includes a fixed plate (402) located inside the housing (401). A take-up reel (403) is provided above the fixed plate (402). A first rotating block (404) is provided at the bottom of the take-up reel (403). The top of the first rotating block (404) is fixedly connected to the top of the take-up reel (403). The bottom of the first rotating block (404) is rotatably connected to the fixed plate (402). The take-up reel (403) is connected to the traction line (3). A second rotating block (406) is provided at the top of the take-up reel (403). The second rotating block (406) is fixedly connected to the take-up reel (403). The top of the second rotating block (406) passes through the housing (401) and extends to the outside of the housing (401). The second rotating block (406) is rotatably connected to the housing (401).

7. An adjustable-angle interventional biopsy needle suitable for deep tumors according to claim 6, characterized in that: The second rotating block (406) is provided with a dial (405) on its top. The outer shell (401) below the dial (405) is provided with a scale groove (407). A connecting rod (408) is fixedly connected to the lower surface of the dial (405). A pointer (409) is fixedly connected to the bottom of the connecting rod (408). An angle scale (410) is provided on the surface of the scale groove (407).

8. A sampling method for an adjustable-angle interventional biopsy needle suitable for deep tumors, applied to the adjustable-angle interventional biopsy needle for deep tumors described in claims 1-7, characterized in that: Includes the following steps: S1. Perform a preoperative scan on the patient to determine the location, size, and relationship of the tumor to surrounding critical organs, and plan a safe initial straight path that passes through healthy tissue as far as possible and avoids all important structures. Perform routine disinfection and anesthesia on the puncture site, and then use a standard guide needle to puncture near the target area to establish a channel, and then remove the guide needle. S2. Insert the initial state guide sheath (1) along the channel established by the introduction needle, so that its distal end reaches the predetermined position outside the tumor edge. By rotating the dial wheel (405), the dial wheel (405) drives the first rotating block (404) to rotate. The rotation of the first rotating block (404) drives the winding wheel (403) to rotate, so that the winding wheel (403) winds up the traction line (3), thereby slowly and accurately adjusting the bending angle and direction of the active bending tube (201) at the end of the traction line (3), so that its tip is aligned with the specific target area of ​​the tumor. This process is carried out under real-time CT scan monitoring to ensure accurate and safe angle adjustment. S3. Keeping the angle and position of the guide sheath (1) unchanged, push the flexible biopsy needle core (501) forward through the working channel of the guide sheath (1). The flexible biopsy needle core (501) will advance along the preset curved path of the guide sheath (1), and its needle tip will finally reach the target tissue accurately. After the image confirms that the needle tip position is correct, the sampling groove (502) opens and is embedded in the tissue. At this time, rotate the needle core to cut off the tissue sample in the groove and seal it in the groove. Withdraw the needle core with the sample taken from the sheath and collect the sample. S4. When multiple sampling points are required, there is no need to move the guide sheath (1). Simply change the bending angle of the sheath and / or rotate the direction of the sheath by slightly changing the external operating mechanism (4) to define a completely new path for the needle core. Insert a new or debrided biopsy needle core and repeat S3 to obtain a second and third sample from another area of ​​the tumor. This process can be repeated multiple times to achieve efficient and accurate sampling of different parts of the tumor. S5. After all sampling is completed, adjust the bending angle of the guide sheath (1) back to the initial straight state, smoothly withdraw the entire system from the patient's body, and apply pressure to the puncture point for hemostasis and treatment.

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