Distributed pre-powder-feeding hemodialysis concentrated solution centralized preparation system

Abstract

The invention discloses a distributed pre-powder-feeding hemodialysis concentrated solution concentrated solution preparation system which comprises a plurality of independent pre-powder-feeding bins, and each powder bin is used for containing a preset part of dialysis powder; the stirring barrel is used for mixing and dissolving dialysis powder and pure water; the temporary storage tank is used for storing the prepared concentrated solution; a plurality of valves and a pump body; each powder bin is provided with an independent electric valve used for controlling feeding of dialysis powder; weighing modules are arranged at the bottoms of the stirring barrel and the temporary storage tank and are used for monitoring the liquid level in real time; a conductivity probe and a temperature probe are arranged in the stirring barrel and are used for monitoring the dissolution state; by arranging a plurality of independent powder pre-feeding bins and adopting a working mode of sequential starting, distributed, small-batch and continuous automatic preparation of the hemodialysis concentrated solution is realized, the solution preparation amount at a time is reduced, the concentrated solution can be used after being prepared, the storage time of the concentrated solution in a storage tank is greatly shortened, and the production efficiency is improved. And the risk of microorganism breeding and reproduction is reduced.

Description

Technical Field

[0001] This invention relates to the field of hemodialysis technology, and in particular to a distributed pre-dosed hemodialysis concentrate centralized preparation system. Background Technology

[0002] Centralized hemodialysis concentrate supply systems are key equipment in modern blood purification treatment, used to continuously and stably provide concentrates that meet quality requirements to multiple dialysis machines. Currently, there are various solution preparation process modes in this field, each with its own characteristics but also with corresponding technical limitations.

[0003] Existing centralized concentrate supply systems fall into two modes: A representative example is the on-demand, centralized concentrate supply system from Toray Industries, Japan. This system has a powder feeding hopper. After dialysis powder is added to the hopper, the system first fills a mixing tank with water (approximately 10 liters, enough for 1-2 people). After water is added, stirring is started, and then a spiral powder feeding mechanism slowly adds the dialysis powder to the mixing tank while stirring. Once the desired concentration is reached, conductivity monitoring is used, and powder feeding and stirring are stopped. The concentrated concentrate is then transferred to a storage tank (approximately 18 liters). The storage tank, through a transfer pump and filter, delivers the concentrate to the hemodialysis machine for use.

[0004] The advantage of this solution is its immediate usability, but the volume of solution prepared each time is small. If the powder feeding mechanism malfunctions, the liquid temporarily stored in the reservoir will quickly run out, leaving the hemodialysis machine without liquid. Our on-site visits to users of this type of equipment revealed that because the powder outlet of the powder hopper is located above the mixing tank, rising moisture from the mixing tank combines with the dialysis powder at the outlet, forming clumps. Operators must regularly clean the clumps of dialysis powder from the outlet daily. Therefore, this solution not only carries the risk of solution preparation failure but also increases the workload of the operators.

[0005] The traditional solution preparation and powder dispensing method used in China and Europe and the United States involves large-volume mixing and storage tanks. Each day, 1-2 hours before the dialysis machine is used, powder needs to be manually added, stirred, dissolved, and then transferred to the storage tank for the machine's use. The disadvantages of this large-scale system are that powder dispensing requires manual operation, the amount of liquid prepared at one time is large, it cannot be used immediately after preparation, and it is prone to bacterial growth. Sterilization and daily emptying consume a large amount of manpower, electricity, and purified water, which does not conform to the current national advocacy of energy conservation.

[0006] Therefore, in response to the problems mentioned above, this invention proposes a distributed pre-dosed hemodialysis concentrate centralized dispensing system. Summary of the Invention

[0007] To overcome the problems of powder caking in existing systems, excessive manual intervention, poor solution preparation flexibility, and high risk of microbial control, this invention proposes a distributed pre-dosed hemodialysis concentrate centralized solution preparation system.

[0008] The technical solution of this invention is: a distributed pre-dosed hemodialysis concentrate centralized preparation system, comprising: Multiple independent pre-dosing powder compartments, each used to hold a predetermined number of doses of dialysis powder; A mixing tank is used to mix and dissolve dialysis powder with pure water; A temporary storage tank for storing the prepared concentrate; Multiple valves and pump bodies, including inlet valve, waste discharge valve, dissolving pump, feed pump, transfer pump, circulation pump and heating pump; Each powder hopper is equipped with an independent electric valve to control the feeding of dialysis powder; The bottom of the mixing tank and the temporary storage tank are equipped with a weighing module for real-time monitoring of the liquid level; The mixing tank is equipped with a conductivity probe and a temperature probe to monitor the dissolution state; The control system determines whether to start the next round of solution preparation based on the remaining concentrate in the temporary storage tank and the liquid consumption rate of the dialysis machine, and then switches to the next available powder hopper in sequence.

[0009] It is worth noting that the control system is used to dynamically predict the time when the concentrate will run out based on the real-time liquid level drop rate of the temporary storage tank and the preset downtime, and accordingly start the next round of liquid preparation process in advance to ensure seamless liquid supply.

[0010] Preferably, there are 5 pre-dosing powder bins, namely powder bin 1, powder bin 2, powder bin 3, powder bin 4 and powder bin 5, each of which can hold dialysis powder for 1 to 20 people.

[0011] Preferably, a feed pump and a dual-nozzle water inlet structure are provided between the mixing tank and the powder silo to pump water from the mixing tank into the bottom of the powder silo, mix the powder and water in a stirring manner, and then return the mixture to the mixing tank.

[0012] Preferably, the dual nozzles are arranged symmetrically, and their jet direction can form a vortex at the bottom of the powder hopper to accelerate the wetting and initial dissolution of the dialysis powder and prevent the powder from clumping or adhering to the hopper wall.

[0013] Preferably, the dissolving pump is located at the bottom of the mixing tank and is used to circulate and stir the liquid in the tank in a jetting manner to accelerate dissolution.

[0014] It is worth noting that the nozzle of the dissolving pump is oriented toward the central axis of the mixing tank and forms an acute angle with the bottom of the tank, which creates a violent turbulent flow of liquid inside the tank, ensuring that all dialysis powder is dissolved within 15 minutes.

[0015] Preferably, the control system calculates whether to continue dispensing liquid based on the remaining amount of concentrate in the temporary storage tank, the liquid dispensing rate, and the preset downtime, and starts the next powder hopper to dispense liquid when the liquid volume is lower than the set threshold.

[0016] Preferably, the set threshold is a dynamic value that is adaptively adjusted based on the total number of all online dialysis machines and the average flow rate.

[0017] Preferably, the system has an automatic start / stop time. After the set time is reached, the liquid preparation program is automatically started, starting from powder bin No. 1 and preparing the liquid in sequence. After completion, it automatically switches to the next powder bin.

[0018] It is worth noting that the switching logic of the powder hopper is sequential switching, but when the system detects that a powder hopper is faulty or has no powder, it will automatically skip the powder hopper and activate the next normal powder hopper to ensure that the liquid preparation process is not interrupted.

[0019] Preferably, the powder hopper is equipped with a powder shortage detection and alarm function. When the powder hopper is empty, the system will alert the user via a touch screen and sound and light.

[0020] Preferably, the powder shortage detection is achieved by a weighing sensor or photoelectric sensor installed at the bottom of the powder hopper. When the last available powder hopper also triggers a powder shortage alarm, the system will activate the highest level audible and visual alarm and suspend the liquid preparation process.

[0021] Preferably, the liquid preparation trigger capacity of the temporary storage tank is dynamically adjusted according to the size of the dialysis room: when the liquid consumption is large, liquid preparation is started when 50% of the capacity remains; when the liquid consumption is small, liquid preparation is started when 20% of the capacity remains.

[0022] It is worth noting that this dynamic adjustment mechanism ensures that the concentrate is stored in the temporary storage tank for a shorter time when used at low flow rates, further reducing the risk of microbial growth.

[0023] Preferably, the system supports pre-dosing the required dialysis powder for the next day on the previous day, enabling unattended automatic solution preparation.

[0024] Preferably, the transfer pump delivers the prepared concentrate through a filter to a temporary storage tank, and then the circulating pump delivers it to the dialysis machine's liquid supply line. The liquid supply module is equipped with a pressure reducing valve to maintain the normal liquid suction pressure of the dialysis machine.

[0025] It is worth noting that the filter is a precision filter with a filtration accuracy of 0.22μm, used to ensure the sterility of the concentrate, and the pressure reducing valve keeps the pressure in the supply line stable within the negative pressure range required by the dialysis machine.

[0026] The beneficial effects of this invention are: 1. This invention achieves distributed, small-batch, and continuous automated preparation of hemodialysis concentrate by setting up multiple independent pre-dosing powder bins and adopting a sequential activation working mode. This reduces the amount of concentrate prepared per batch, enabling the concentrate to be used immediately after preparation. It significantly shortens the storage time of the concentrate in the storage tank, effectively reducing the risk of microbial growth and reproduction, and meets the strict requirements of the "Standard Operating Procedures for Blood Purification" regarding the storage time limit of the concentrate.

[0027] 2. This system uses a control system to monitor the remaining amount of concentrate in the temporary storage tank and the liquid consumption rate of the dialysis machine in real time, and dynamically calculates the remaining usage time to decide whether to start the next powder silo for liquid preparation. This demand-based precision liquid preparation mode avoids the liquid waste caused by inaccurate estimation in traditional large-scale liquid preparation, while also ensuring the continuity of liquid supply and achieving an effective balance between on-demand preparation and supply guarantee.

[0028] 3. This system employs a feed pump and a dual-nozzle water inlet structure between the powder silo and the mixing tank, and utilizes a dissolving pump to create jet mixing within the mixing tank. This active and highly efficient mixing and dissolving method can completely dissolve the dialysis powder in a short time, avoiding problems such as powder clumping and insufficient dissolution. At the same time, the airtight design of the powder silo also prevents caking at the powder outlet caused by rising water vapor, reducing daily maintenance.

[0029] 4. The system's multiple powder compartments serve as backups for each other. When one powder compartment fails due to a malfunction or lack of powder, the control system can automatically switch to the next working powder compartment to continue dispensing the solution. This redundancy design enhances the reliability and fault tolerance of the entire solution supply system, effectively avoiding the risk of interruption of the entire dialysis treatment center's solution supply due to a single component failure, and ensuring the stable progress of treatment.

[0030] 5. This invention adopts a pre-filling powder design, which allows operators to pre-fill the powder hopper with all the dialysis powder needed for the next day before the end of the current workday. The system can automatically start dispensing the solution at a set time, completely eliminating the manual powder filling step before the machine is used the next day. This truly realizes the full automation and unattended operation of the dispensing process, greatly reducing the workload of operators and lowering labor costs. Attached Figure Description

[0031] Figure 1 The diagram shown is a schematic representation of the system framework of this invention. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Please see Figure 1 This invention provides an embodiment of a distributed pre-dosed hemodialysis concentrate centralized preparation system: In this embodiment, the stirring tank serves as the core dissolving container, with a volume designed to flexibly handle concentrated solutions for 1-20 people. The tank body is made of corrosion-resistant material and is equipped with conductivity and temperature probes inside for real-time monitoring of the liquid's concentration and temperature. A high-precision weighing module is installed at the bottom of the tank for precise control of the water inflow.

[0034] The storage tank is used to store the prepared and filtered concentrate, serving as a buffer container for supplying the dialysis machine. It also has a weighing module at the bottom to monitor the concentrate level in real time. Its volume is typically larger than the mixing tank to handle short-term peak demand.

[0035] The piping and valve assembly includes V1 inlet valve (connected to a pure water source), V2 waste discharge valve (connected to a mixing tank for discharging substandard liquids or cleaning wastewater), and V5 waste discharge valve (connected to a temporary storage tank for system evacuation or disinfection). All piping in contact with liquids is made of medical-grade inert materials.

[0036] The pump set includes an M1 feed pump, connected between the mixing tank and the powder hopper, used to pump pure water from the mixing tank into the powder hopper. An M2 dissolving pump is located at the bottom of the mixing tank, with its outlet extending through a pipeline to the upper part of the mixing tank, forming a jet nozzle to generate intense turbulence within the tank, accelerating dissolution. An M3 transfer pump is located at the mixing tank outlet, used to pump the prepared concentrate to the storage tank. A circulation pump is located at the storage tank outlet, responsible for maintaining the circulation of the concentrate in the supply pipeline and providing a stable suction pressure for the dialysis machine. An optional heating pump can be installed to heat the pure water or concentrate at low temperatures to optimize the dissolution rate.

[0037] In this embodiment, the system has five independent and identical pre-feeding powder bins. In practical applications, the number of bins can be adjusted according to the size of the dialysis center. Each bin has an electric valve (e.g., DV1, DV2, ..., DV5) installed at its bottom outlet to control the feeding opening and closing. Each bin has a sealed cover with a sealing ring to prevent moisture from entering and causing the pre-feeding dialysis powder to clump. The bottom of each bin has a dual-nozzle water inlet structure. These symmetrically arranged nozzles have precisely calculated jet directions to create a vortex at the bottom of the bin, initially wetting and mixing the falling dialysis powder to form a uniform slurry, preventing clumping. A weighing or photoelectric sensor can be optionally installed below each bin to detect the presence of remaining dialysis powder.

[0038] In this embodiment, a precision filter with an accuracy of 0.22 μm is installed on the pipeline from the outlet of the transfer pump (M3) to the temporary storage tank to intercept any microorganisms and particulate impurities that may be present, ensuring that the concentrate delivered to the temporary storage tank is in a sterile state. The liquid supply module is equipped with a pressure reducing valve to stably convert the positive pressure established by the circulation pump into the negative pressure suction environment required by the dialysis machine, ensuring smooth liquid suction and stable flow rate for each dialysis machine.

[0039] In this embodiment, the system is controlled and monitored via a PLC or industrial computer, in conjunction with a human-machine interface touchscreen. The control system receives signals from the weighing modules (WT1, WT2), conductivity probe (CT1), temperature probe, and status sensors of each powder hopper. Simultaneously, it outputs commands to control the opening and closing of all pumps, electric valves, water inlet valves, and waste discharge valves, as well as their rotation speeds. The control system is pre-installed with liquid dispensing control algorithms and liquid volume prediction algorithms.

[0040] Furthermore, the workflow of this invention will be described in detail below: The first step, after the first day of treatment is completed and the system is disinfected, is for the operator to open the sealed lids of each powder compartment and fill the five compartments with the dialysis powder needed for the next day's treatment. For example, each compartment is filled with dialysis powder for 10 people. After completion, the lids are closed, and the system enters standby mode. The system has an automatic start-up and shutdown time. After the preset start-up time is reached (e.g., 6:00 AM the next day), the control system powers on and performs a self-test. After the self-test passes, the system first checks the status of each powder compartment. Once it confirms that there is powder in compartment 1, it starts the solution preparation program starting from compartment 1.

[0041] The second step, taking silo 1 as an example, involves the control system opening the V1 inlet valve to inject pure water into the mixing tank. The weighing module WT1 monitors the water inflow in real time. When the water volume reaches the preset target volume (matching the amount of dialysis powder in silo 1), the V1 valve closes. At this time, the DV1 valve (silo 1 outlet valve) and the DV1-2 valve (the inlet valve connecting the dual nozzles) open simultaneously. The M1 feed pump starts, drawing the pure water from the mixing tank into the dual nozzles at the bottom of silo 1. The jets from the nozzles create a vortex within the silo, lifting the dialysis powder and initially mixing it into a slurry. Under gravity, this slurry naturally flows back to the mixing tank through the opened DV1 valve.

[0042] While the dialysis powder is circulating and mixing within the silo, the M2 dissolving pump starts, drawing water from the bottom of the mixing tank and then injecting it back into the tank at a specific angle and speed through a nozzle located above the liquid surface. This design creates a strong turbulent flow field within the tank, ensuring that the newly added slurry and the water in the tank are thoroughly agitated and sheared, rapidly dissolving the dialysis powder particles. This ensures that the dialysis powder in the silo is completely dissolved and evenly dispersed in the mixing tank within 15 minutes.

[0043] Third, after the set stirring time is over, the control system reads the value of the conductivity probe CT1. When the conductivity value stabilizes within the preset target concentration range and remains so for a certain period of time, the system determines that the concentrate is qualified. After the qualification is determined, the control system closes the M2 dissolving pump, the M1 feeding pump, the DV1 valve and the DV1-2 valve, and the M3 transfer pump starts to pump out all the qualified concentrate in the stirring tank. After passing through the 0.22μm precision filter, it is transported to the temporary storage tank. After the transfer is completed, the M3 transfer pump stops.

[0044] Fourth, the circulating pump continues to run, delivering the concentrate in the temporary storage tank to the dialysis center's supply network for use by each dialysis machine. A pressure reducing valve ensures stable network pressure, and the control system continuously monitors the reading of the temporary storage tank's weighing module WT2 to obtain real-time liquid volume. The system periodically calculates the liquid consumption rate S (L / min) every minute. ,in This is the liquid volume from the previous cycle. It is a calculation cycle; the system predicts the remaining liquid volume's usable time based on the current liquid volume and consumption rate. The system will With a dynamic threshold Comparison, Defined as the time from the current moment to the preset infusion stop time (e.g., the end time of treatment for the day), plus a 20-minute safety buffer period. If If so, the next round of solution preparation will begin.

[0045] Fifth, when the decision conditions are met, the control system automatically switches to the next available powder bin (such as bin 2) and repeats the liquid preparation and transfer process from the second to the third step. This process is repeated until all powder bins are used up or the system shutdown time is reached.

[0046] The sixth step involves a dynamic capacity triggering mechanism. Based on the set total number of dialysis machines, N, the system determines the fluid usage scale. When N ≥ 20, the system is designated as high-flow mode, and the trigger threshold for replenishment is set to 50% of the total storage tank capacity. When N < 20, the system is designated as low-flow mode, and the trigger threshold for replenishment is set to 20% of the total storage tank capacity. This mechanism ensures faster turnover and shorter storage time of the concentrate in the storage tank during low-flow usage, reducing microbial risk. During high-flow usage, the system prepares the concentrate in advance, guaranteeing a continuous supply.

[0047] Step 7: When a sensor in a toner hopper detects a toner-out status, the icon for that hopper on the touchscreen will turn red and flash as a warning. When the last available toner hopper also runs out of toner, the system will immediately trigger an audible and visual alarm to alert staff to add toner urgently. If the conductivity remains below standard for an extended period or the motor is overloaded, the system will immediately stop the relevant processes and sound an alarm.

[0048] Furthermore, the present invention provides an embodiment: This embodiment is configured in a blood purification center with 25 dialysis machines. There are 5 powder containers, each with a capacity of 15 doses of dialysis powder. The volume of the mixing tank is equivalent to the liquid volume of 15 doses. The total volume of the temporary storage tank is set to 150 liters.

[0049] Before leaving get off work the previous day, the nurses filled each of the five powder containers with dialysis powder for 15 people's doses of solution A.

[0050] The next morning at 6:00 AM, the system started automatically, beginning with the preparation of the solution from the No. 1 powder silo. About 20 minutes later (including the time for water intake, dissolution, testing, and transfer), the first batch of approximately 45 liters of qualified concentrated solution entered the temporary storage tank, and the circulation pump began supplying the solution to the pipeline.

[0051] After treatment begins, 25 dialysis machines operate simultaneously, and the fluid consumption rate is relatively fast. When the system detects that the fluid level in the temporary storage tank drops to 50% (approximately 75 liters), it automatically starts the No. 2 powder hopper to prepare the fluid according to the dynamic capacity triggering mechanism.

[0052] This cycle continued until the end of the day's treatment. The system used powder containers 1, 2, 3, and 4 in sequence, preparing a total of about 180 liters of concentrated solution. Powder container 5 was not used as an emergency backup.

[0053] After treatment, the system performs a cleaning and disinfection procedure, and the nurse only needs to replenish the dialysis powder in the four powder containers that have been used the next day.

[0054] Furthermore, the present invention provides an embodiment: This embodiment is compared with the traditional large-volume manual solution preparation system. It was implemented in a dialysis center with 20 machines and ran continuously for 5 working days.

[0055] First, the traditional system requires manual powdering once a day before treatment, which takes about 30 minutes and requires 2 people to operate each time. The total manual time for 5 days is: 5 × 2 × 0.5 = 5 hours.

[0056] The system of this invention only needs to perform pre-powdering once every 5 days (to prepare for subsequent working days), with one person operating for 20 minutes each time, and the total manual time is 0.33 hours.

[0057] Second, traditional systems prepare solutions once a day, and most of the concentrate is stored in the tank for more than 8 hours.

[0058] The system of this invention is ready to use immediately, and the average storage time of the concentrate in the temporary storage tank is less than 2 hours.

[0059] It can be concluded that the present invention significantly shortens the storage time of the concentrate and reduces the risk of microbial growth.

[0060] Third, on the third day of the experiment, the No. 1 powder hopper electric valve of the system of the present invention was manually shut off to simulate its failure.

[0061] After a failure to prepare the solution in compartment 1, the system of this invention automatically detected the fault and seamlessly switched to compartment 2 within 2 minutes, successfully preparing the solution without affecting normal solution supply. Traditional systems do not have this function.

[0062] As can be seen from the above, this invention, by adopting a distributed pre-dosing powder silo structure, a dual dissolution mechanism combining dual-nozzle vortex initial mixing within the powder silo with turbulent strong dissolution by a dissolving pump in the mixing tank, and integrating an intelligent dispensing algorithm based on liquid volume prediction and dynamic capacity triggering, successfully achieves small-batch, fully automated, and ready-to-use production of hemodialysis concentrate. This system allows staff to pre-douse powder for unattended operation, significantly reducing the burden of manual operation and the storage time of concentrate in the tank, effectively reducing the risk of microbial growth. At the same time, its multi-powder silo redundancy design and automatic switching function ensure that a single point of failure does not affect the overall liquid supply, greatly improving the reliability and fault tolerance of the system.

[0063] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments that can be applied to other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A distributed pre-dosed hemodialysis concentrate centralized preparation system, characterized in that, Including: Multiple independent pre-dosing powder compartments, each used to hold a predetermined number of doses of dialysis powder; A mixing tank is used to mix and dissolve dialysis powder with pure water; A temporary storage tank for storing the prepared concentrate; Multiple valves and pump bodies, including inlet valve, waste discharge valve, dissolving pump, feed pump, transfer pump, circulation pump and heating pump; Each powder hopper is equipped with an independent electric valve to control the feeding of dialysis powder; The bottom of the mixing tank and the temporary storage tank are equipped with a weighing module for real-time monitoring of the liquid level; The mixing tank is equipped with a conductivity probe and a temperature probe to monitor the dissolution state; The control system determines whether to start the next round of solution preparation based on the remaining concentrate in the temporary storage tank and the liquid consumption rate of the dialysis machine, and then switches to the next available powder hopper in sequence.

2. The distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The number of pre-dosing powder compartments is 5, namely powder compartment 1, powder compartment 2, powder compartment 3, powder compartment 4 and powder compartment 5, each powder compartment can hold dialysis powder for 1 to 20 people.

3. The distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: A feed pump and a dual-nozzle water inlet structure are provided between the mixing tank and the powder silo to pump water from the mixing tank into the bottom of the powder silo, mix the powder and water in a stirring manner, and then return it to the mixing tank.

4. The distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The dissolving pump is located at the bottom of the mixing tank and is used to circulate and stir the liquid in the tank in a jetting manner to accelerate dissolution.

5. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The control system calculates whether to continue dispensing liquid based on the remaining amount of concentrate in the temporary storage tank, the dispensing rate, and the preset downtime. When the liquid volume is lower than the set threshold, it starts the next powder hopper to dispense liquid.

6. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The system has an automatic start-up and shutdown time. After the set time is reached, the liquid preparation program will be started automatically, starting from powder bin No. 1 and preparing the liquid in sequence. After completion, it will automatically switch to the next powder bin.

7. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The powder hopper is equipped with a powder shortage detection and alarm function. When the powder hopper is empty, the system will alert the user through a touch screen and sound and light.

8. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that, The liquid preparation trigger capacity of the temporary storage tank is dynamically adjusted according to the size of the dialysis room: when the liquid consumption is large, liquid preparation is started when 50% of the capacity remains; when the liquid consumption is small, liquid preparation is started when 20% of the capacity remains.

9. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The system supports pre-dosing the required dialysis powder for the next day on the previous day.

10. A distributed pre-dosed hemodialysis concentrate centralized preparation system according to claim 1, characterized in that: The transfer pump delivers the prepared concentrate through a filter to a temporary storage tank, and then the circulation pump delivers it to the dialysis machine's liquid supply line. The liquid supply module is equipped with a pressure reducing valve to maintain the normal liquid suction pressure of the dialysis machine.

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