Topically applicable compositions containing solubilizers of lipophilic active ingredients

Abstract

The present invention relates to a composition for topical application for medical or cosmetic purposes, containing a micellar extract or a micellar lipophilic active ingredient, in particular to a composition having one or more solubilizers of a lipophilic active ingredient, the lipophilic active ingredient is selected from the group consisting of plant extracts, plant extracts, plant parts, plant therapeutic agents, resins, vitamins, enzymes, proteins, algae, functional actives and / or coenzymes, and mixtures and combinations thereof.

Description

TECHNICAL FIELD

[0001] The present invention relates to a finished product for topical application having a micellar extract or a micellarized lipophilic active ingredient. BACKGROUND

[0002] The incorporation of lipophilic and in water almost insoluble or insoluble active ingredients into the finished product poses problems, since for a uniform distribution such active ingredients can only be mixed into the finished product after a corresponding time-consuming and expensive method using oil / oil mixtures or oil-water emulsions. In order to mix the fat-soluble substances into the finished product, they have to increase their volume due to the undesired large amount of oil, thereby ensuring an optimal uniform distribution in the finished product.

[0003] The preparation of a solubilizate of essential oils is therefore described in EP 1 768 497 B1 to be able to introduce substances which are insoluble or poorly soluble in water uniformly into the finished product.

[0004] WO 2021 / 037656 A1 describes a folic acid-solubilizate for use in nutritional supplements and for wastewater treatment in sewage treatment plants. SUMMARY

[0005] It is the task of the present invention to provide a finished product for topical application, in which care and curative active ingredients for the skin are treated in such a way that they are well absorbed by the skin and lead to an improvement in the skin impression there. In addition, the finished product should be distinguished by good stability and durability.

[0006] This task is solved in the case of a finished product for topical application by the product containing a solubilizate of a lipophilic active ingredient.

[0007] The present invention therefore relates to a finished product or composition for topical application, which comprises a solubilizate of a lipophilic active ingredient as defined in claim 1. Therefore, a solubilizate of a lipophilic active ingredient as defined in claim 1 is used for the preparation of a finished product or composition for topical application.

[0008] Within the scope of the present application, the terms "(one or more) finished product", "(one or more) product" and "(one or more) composition" are used synonymously.

[0009] The finished product contains the solubilized active ingredient, which can be better processed into the product and contributes to improved stability there compared to the pure isolate of the active ingredient.

[0010] The solubilizer is a water-soluble microparticle that surrounds a lipophilic substance. The purpose of preparing the solubilizer is to surround a lipophilic, insoluble, or poorly water-soluble substance in such a way that it becomes water-soluble. A combination of one or more emulsifiers, lipophilic active ingredients, and adjuvants forms a stable, transparent, and water-soluble solubilizer. Preferred emulsifiers include polysorbate, poloxamer (Lutrol), gum arabic, sucrose stearate, Dermofeel G 10 LW (70) MB, paste Dermofeel® G 10 L, PEG-40 hydrogenated castor oil, lecithin, phosphatidylcholine, or D-α-tocopherol polyethylene glycol 1000 succinate (TPGS; other names: vitamin ETPGS, tococelen (INN)). For example, poloxamer is a suitable emulsifier. Poloxamer is a synthetic block copolymer composed of ethylene oxide and propylene oxide. It exists in different liquid and semi-solid forms, and is soluble to slightly soluble in water. Poloxamer is amphiphilic. For example, TPGS is another amphiphilic emulsifier, which has both hydrophilic and lipophilic molecular moieties. The polyethylene glycol moiety is the polar head and the tocopheryl succinate is the lipophilic tail. This amphiphilic property leads to the self-association (microparticle formation) of TPGS in water. Thus, the lipophilic component is surrounded inside the microparticles (lipophilic moiety) and dissolved in water through the water-soluble surface of the microparticles. Possible adjuvants for improving the solubility of substances that are poorly soluble in water include, for example, ethanol (96%), polysorbate, and glycerol (anhydrous). For further details on the preparation of solubilizers, see the contents of the applicant's European applications EP 3 675 825 (EP 18 738 297) and EP 3 675 824 (EP 18 737 274).

[0011] The active ingredient, stably enclosed within microparticles, is protected from the effects of heat, light, and / or chemical instability (e.g., oxidation). The microparticles are characterized by a hydrophobic core containing a lipid-soluble substance, which is surrounded by a layer of hydrophilic emulsifier.

[0012] In the preparation of the finished product, the solubilizer is used as a separate raw material. The advantage of this is that it can be directly incorporated into the aqueous phase or completely integrated into it. Therefore, it is possible to produce not only oil / water (oil-in-water) but also water / oil (water-in-oil) and purely aqueous products without adding fats / oils or emulsifiers.

[0013] Water-soluble microparticles are uniformly distributed in the aqueous solution. This ensures the uniformity of the active ingredients in the product. Furthermore, the hydrophobic active ingredients (extracts, lipophilic vitamins, etc.) encapsulated within the microparticles are protected from external influences. This ensures improved stability of the active ingredients in the product.

[0014] Finished products intended for topical application are primarily cosmetic products, but also include medical or pharmaceutical compositions for application to the skin or mucous membranes. Examples include creams, lotions, emulsions, serums, gels, drops, emulsions, balms, fluids, shampoos, ointments, masks, foams, sprays, or toners. These finished products can be water-based or fat / oil-based. They can be used for the care, cleansing, and / or treatment of skin or mucous membranes from head to toe, especially on the face. Facial masks, creams, and serums are preferred.

[0015] As active ingredients in the aforementioned finished products for topical application, consideration is given to lipophilic plant extracts, plant extracts, phytothenic agents, algae, resins, vitamins, enzymes, proteins, functional active substances and / or coenzymes, as well as mixtures and combinations thereof. All mentioned active ingredients possess positive effects on the skin, including both cosmetic applications for caring for and cleansing any skin type, particularly for achieving anti-aging effects, and therapeutic applications for skin conditions such as acne, erysipelas, urticaria, herpes, neurodermatitis, burns, or psoriasis.

[0016] Examples of possible plant extracts or herbal remedies include evening primrose (Oenotherabiennis), crape myrtle (Cardiospermum halicacabum), pansy (Viola tricolor), horsetail (Equisetum arvense), German chamomile (Matricaria recutita), witch hazel (Hamamelis virginiana), Mahonia aquifolium, birch (Betula pendula), ylang-ylang, Siberian ginseng (Eleutherococcus senticosus), shea butter (avocado oil), turmeric (Curcuma langa), narrow-leaved lavender (Lavandula angustifolia), hypericum (Hypericum perforatum), chondrus crispus (Chondrus crispus), hops (Humulus lupulus), green tea (Camellia sinensis L.), centella asiatica, mallow (Malva sylvestris), and mosquito grass (Filipendula). ulmaria, calendula officinalis L., or red clover (Trifolium pratense).

[0017] Possible examples of algae include brown algae, red algae, green algae, or blue algae.

[0018] Possible examples of vitamins include vitamin E, vitamin A, provitamin A (β-carotene), vitamin C, vitamin B3 (niacin), panthenol, provitamin B5, and vitamin B7 (biotin).

[0019] Examples of enzymes, proteins, and coenzymes are lipases, cellulases, amylases, proteases, collagen, acetyl hexapeptide-8, pentapeptide-18, or coenzyme-10 (Q10).

[0020] Possible examples of resins include frankincense, propolis, or myrrh.

[0021] Other examples of functionally active substances include fruit acids (such as glycolic acid, lactic acid, malic acid, citric acid, and tartaric acid), resveratrol, pterostilbene, astaxanthin, or substances that can interact with the hypoxia-inducible factor (HIF), mTor, p53, GDNF, and GLUT1 pathways.

[0022] The particularly preferred solubilizer is: Micronized Q10 or astaxanthin -> Applications: Anti-wrinkle, energy booster, antioxidant Micronized frankincense -> Applications: antibacterial, anti-inflammatory Micronized propolis -> Applications: antibacterial, anti-inflammatory Micronized Siberian ginseng, resveratrol, pterostilbene, or HIF inhibitors -> Applications: anti-aging, anti-wrinkle, antibacterial, anti-inflammatory. One or more additional (water-soluble) substances with positive effects on the skin can be added to the solubilizer or the product for topical application. These substances include, for example, hyaluronic acid, aloe vera, centella asiatica extract, green tea extract, lactic acid, urea, or amino acids. In the case of a (facial) mask embodiment, the (water-soluble) substances can be applied directly to the mask.

[0023] In addition, cosmetic or pharmaceutical additives may be present, such as stabilizers, emulsifiers, preservatives, thickeners and / or binders.

[0024] To prevent oil and water from repelling each other, all emulsions require emulsifiers or solubilizers for stability. Emulsifiers are located at the interface between the two liquids and possess both polar and nonpolar molecular portions. The polar ends of the emulsifier molecule attach to the water molecules, while the nonpolar ends attach to the oil molecules. Through this "docking," the emulsifier reduces the interfacial tension between the oil and water phases, thus stabilizing the emulsion. Suitable emulsifiers include, for example, lauryl ether 4, cetearyl ether-15, PEG-8, sucrose stearate (E 473), methylglucose sesquistearate, or glyceryl stearate.

[0025] Stabilizers are often added to emulsifiers. They encapsulate the emulsified droplets with a protective film and provide strong cohesion. Stabilizers are, for example, antioxidant vitamins, starch, dextrin, pectin, or proteins. Preferred stabilizers according to the invention (e.g., in creams or facial lotions) are vitamin C or vitamin E, preferably in amounts of 0.2-1.8% by weight, very preferably 0.5-1.0% by weight.

[0026] Thickeners in cosmetic products ensure that the product always has an optimized consistency and increase viscosity. For example, they make lotions thicker and creams more creamy, making them easier to apply and providing a smooth feel on the skin. These can be synthetic thickeners, such as liquid microplastic particles, or natural thickeners, such as cellulose (E 460), xanthan gum (E 415), alginate (E 400-E 405), gellan gum (E 418), pectin (E 440), or carrageenan (E 407). While natural thickeners are more expensive, they are clearly preferred because microplastics are a significant environmental concern.

[0027] Preservatives protect cosmetic products from microbial spoilage and thus contribute to consumer health. Aqueous products are particularly vulnerable because microorganisms can easily multiply and proliferate. Commonly used preservatives include parabens, alcohols (such as ethanol), or halogenated organic substances (such as benzisothiazolinone, methylisothiazolinone, dichlorobenzyl alcohol, and chlorhexidine).

[0028] Binders, as ingredients in cosmetics, ensure the desired cohesiveness (internal cohesion) of the product. They prevent the separation of solid and liquid components. Typically, they are used in amounts less than 2% of the total mass. Hydrophilic colloids (such as alginate) as well as carboxymethyl cellulose, hydroxyethyl cellulose, or xanthan gum are frequently used.

[0029] According to the present invention, it can be shown that when using an active ingredient-solubilizer, greater stability can be achieved in products intended for topical application compared to the isolate of the active ingredient. This is particularly applicable to creams and facial serums, especially those containing propolis, Q10, or frankincense as active ingredients. The stability achieved by the active ingredient-solubilizer can be further enhanced by adding a stabilizer. However, if it is desirable to avoid stabilizers in cosmetic products, the solubilizer is clearly preferred over the isolate, as the solubilizer already contributes to the stability of the product without the need for additional stabilizers. When vitamin E is added at a higher concentration (e.g., 1%), significant stability of the solubilizer is observed compared to the stability of the isolate. This effect is also observed, at least in creams with a high fat content, using 1% vitamin E plus 1% vitamin C.

[0030] Due to the water-soluble nature of solubilizers, they are destined for use in cosmetic formulations where fats or oils are not desired, such as shampoos or face masks.

[0031] The microparticles protect the active ingredients in the core from light exposure, thus contributing to product stability during daily use.

[0032] In a preferred embodiment, the finished product to be applied to the skin is a (facial) mask for medical or cosmetic purposes, which contains microparticle extracts or microparticle-encapsulated lipophilic active ingredients.

[0033] In a preferred embodiment, a ready-to-use face mask is provided for cosmetic or medical purposes, wherein the active ingredients for skin care or healing treatment are processed such that they are well absorbed by the skin and thereby result in an improved skin impression.

[0034] The characteristics of this type of face mask are detailed as follows: • The face mask contains solubilizers for lipophilic active ingredients. • The face mask is made of flexible materials. • If it covers the entire face, it contains openings for, for example, the eyes and nose. To allow for visual perception and unobstructed breathing during application, if the mask covers the entire face, it has openings for the eyes and nose. This enhances user comfort and allows for personalized adjustments to suit their needs. However, it's also possible for the mask to cover only part of the face or neck. It's equally possible that it extends down to the lower chest or covers other parts of the body.

[0035] The face mask is composed of a flexible material. This can be a cellulose-containing material, a cotton-containing material, or a silk-containing material, as well as any combination and mixture thereof. Preferred is bio-cellulose, most preferably a material composed of 90-98% water and 2-10% cellulose. In a preferred embodiment, a face mask composed of 96% water and 4% cellulose is used. Here, the term "bio-cellulose" is understood to refer to a smooth, rough, or granular planar fabric material used to prepare the face mask. The face mask can consist of one or more layers of cellulose or cellulose nonwoven fabric. In a preferred embodiment, the bio-cellulose face mask is prepared by fermenting bacteria. It is 100% compostable and adheres well to the skin due to its properties. Further preferred features of the bio-cellulose face mask are: - Fiber diameter is 2-100 nm - Fiber length 1-9 mm - Three-dimensional structure However, alternatively, other flexible materials are also considered, such as film materials or materials made of cotton or silk fibers. The thickness of one or more layers is flexible and depends on the liquid absorbency of the facial mask required for its respective application.

[0036] The design of a face mask can vary. A face mask can cover the entire face, specific areas of the face, neck, lower chest, or other body parts. The terms "face mask" and "facial mask" are used interchangeably, and the term "face" is not limited to the face alone, but includes the head and neck. It acts as a carrier for active substances that can penetrate the skin.

[0037] Preferably, the face mask according to the invention is sterile and individually packaged. In a preferred embodiment, the face mask (particularly a bio-cellulose face mask) rests on a moistened fabric made of nonwoven fabric and is covered with a perforated white plastic film, allowing the face mask to be folded in the package and preventing it from drying out. The packaging is preferably a film made of aluminum, which can be printed, for example, using CMYK printing.

[0038] The facial mask preferably has eye openings, nasal openings, and optionally a mouth opening. Optional channels for accommodating the wearer's ears may be present in the cheek portion. The face is divided into a forehead portion and a jaw portion, as well as a central eye portion, nose portion, mouth portion, and cheek portion. These portions are assigned to corresponding areas of the facial mask. Optional channels for accommodating ears may be provided on the side adjacent to the central facial portion of the facial mask, surrounding the ears and securely fixing the facial mask in place. Therefore, the facial mask will not unintentionally slip off the face during application.

[0039] In a preferred embodiment of the face mask, at least one notch is also provided for the nose, the notch being formed by a trapezoidal opening. This opening may have a horizontal cut or notch in the face mask extending to the eye area along the axis of symmetry of the facial region, to accommodate different nose shapes. For the nose opening to function, the portion of the mask surrounding the opening is laid on the nose, thus forming a passage for the nose.

[0040] The aforementioned active ingredients, stably encapsulated in microparticles, are protected from the effects of heat, light, and / or chemical instability (e.g., oxidation).

[0041] Because face masks are primarily composed of water, they can be loaded with microparticles. The mask releases its moisture to the skin and, consequently, its active ingredients. Studies have shown that the mask absorbs at least 20%, preferably at least 50%, of the solubilizers used in its preparation.

[0042] The preferred embodiments of the (facial) mask are described in more detail in the following paragraphs: (1) A facial mask having one or more solubilizers of a lipophilic active ingredient, selected from plant extracts, plant extracts, plant parts, phytothenic agents, resins, vitamins, enzymes, proteins, algae, functional active substances and / or coenzymes, and mixtures and combinations thereof. (a) Preferably, the plant extract, plant extract, or phytotherapy is derived from evening primrose (Oenothera biennis), crape myrtle (Cardiospermum halicacabum), pansy (Viola tricolor), horsetail (Equisetum arvense), German chamomile (Matricaria recutita), witch hazel (Hamamelis virginiana), Mahonia aquifolium, birch (Betula pendula), ylang-ylang, Siberian ginseng (Eleutherococcus senticosus), shea butter (avocado oil), turmeric (Curcuma langa), narrow-leaved lavender (Lavandula angustifolia), hypericum (Hypericum perforatum), chondrus crispus (Chondrus crispus), hops (Humulus lupulus), green tea (Camellia sinensis L.), centella asiatica, mallow (Malva sylvestris), and mosquito grass (Filipendula). ulmaria, calendula officinalis L., and red clover (Trifolium pratense) (b) Preferably, the vitamins are vitamin E, vitamin A, provitamin A (β-carotene), vitamin C, vitamin B3 (niacin), and / or vitamin B7 (biotin). (c) Preferably, the enzyme, protein, or coenzyme is lipase, cellulase, amylase, protease, collagen, acetyl hexapeptide-8, pentapeptide-18, and / or coenzyme-10 (Q10). (d) Preferably, the resin is frankincense, propolis, or myrrh. (e) Preferably, the functionally active substance is astaxanthin, resveratrol, pterostilbene, fruit acid, or a substance that can interact with the hypoxia-inducible factor (HIF), mTor, p53, GDNF, and GLUT1 functional pathways. (f) wherein the solubilizer is a combination of (one or more) emulsifiers, fat-soluble active ingredients and adjuvants, wherein the (one or more) emulsifiers are preferably selected from polysorbate, Lutrol and / or D-α-tocopherol polyethylene glycol 1000 succinate and the adjuvants are preferably ethanol, polysorbate and / or glycerin.

[0043] (2) The face mask is preferably made of biological cellulose.

[0044] (3) Masks can be used for cosmetic purposes to care for and cleanse any skin type, with an emphasis on achieving anti-aging effects on the skin.

[0045] (4) Face masks can also be used for treatment of skin diseases, preferably acne, herpes, neurodermatitis, urticaria, erysipelas, burns or psoriasis.

[0046] (5) In addition, dermatological tests were conducted on the masks loaded with the aforementioned solubilizing active ingredients. All masks were suitable for normal and sensitive skin. This means that the microparticles are particularly gentle on the skin. Attached Figure Description

[0047] The invention will be described in more detail with the aid of the accompanying drawings: Figure 1 A facial mask made of bio-cellulose, laid on a non-woven fabric. (1) Nonwoven fabric layer (2) Biocellulose Figure 2 : Facial mask, showing the pores present for use with the eyes, nose, and mouth. (3) Through-hole plastic film Example The present invention is illustrated by the following embodiments.

[0048] Example 1: Stability Study: Microbiological Study of Propolis-Solubilizer For microbiological studies, propolis-solvent prepared from propolis ethanol extract was stored in 50 ml amber glass vials in a phenological test chamber at room temperature and 40°C. Samples were extracted at days 0, 90, and 180 to investigate microbial contamination.

[0049]

[0050] nn: Not detected; NG: Detection limit result: No bacteria were detected in any of the samples studied at room temperature or at 40°C. Microbial testing was performed after more than six months, and even after 12 months, but due to viscosity changes, the samples had to be diluted 1:10, resulting in a detection limit of 10, and bacteria were not detected in the solubilized mixture even after that time.

[0051] Example 2: Stability testing: Aging test of propolis-solvent examples For aging tests, propolis-solubilized samples were stored at room temperature and 40°C. Samples were extracted at days 0, 30, 90, and 270. The following parameters were measured: color, turbidity, pH, density, and sedimentation. Because propolis naturally has a darker color, the sample was diluted 1:10 with water to determine turbidity and pH.

[0052]

[0053]

[0054] Example 3: Loading of the face mask The cut face mask is placed in an airtight package and loaded with an essence containing solubilized coenzymes in a filling device. Here, the device dispenses a specific amount of essence (15-45 g) into the finished package. The essence is evenly distributed by repeatedly pressing the sides of the package, thus ensuring the mask is completely saturated with essence. The package is then welded shut. After 3-7 days of storage, the mask is saturated with essence.

[0055] Preparation of serum:

[0056] Other features of bio-cellulose face masks: - Fiber diameter is 2-100 nm - Fiber length 1-9 mm - Three-dimensional structure Example 4: Measuring the stability of solubilizers in face masks Solubilizers of different active ingredients were extracted from the corresponding face masks and their stability was measured.

[0057] To investigate the stability of solubilizers, the components in the face mask and serum were identified and measured over a three-month period at room temperature and 40°C. Q10 solubilizers, Siberian ginseng solubilizers, propolis solubilizers, and frankincense solubilizers were analyzed. During the development of the analytical methods, it was found that at least 50% of the concentration of the raw materials used was rediscovered in the face mask. This can be explained by diffusion. Before adding the bio-cellulose face mask (i.e., a pre-made mask with up to 98% water by weight) to the serum, a concentration equilibrium occurs. In this case, the face mask absorbs at least 50% of the active ingredient. The determined initial concentration values ​​are the starting values ​​from zero-point measurements and represent 100% of the initial values.

[0058] Q10-bio-cellulose mask post-treatment Cut the mask soaked in a 3% serum solution into pieces of approximately 1 g each, and add approximately 4 g of tetrahydrofuran (THF) to each tube, then immerse for at least 4 hours. During the extraction time, vortex the sample material in the tube. Add the total weight of the mask sample to the total weight of the solvent and record the result.

[0059] Take 100 μl of the solution containing the sample and mix it with 900 μl of methanol / 1-propanol (50 / 50 v / v). The sample is then measured on HPLC-UV.

[0060] The content in the extracted solution can be determined using a 6-point calibration curve ranging from 1 to 100 μg / ml. Quality control samples with predetermined values ​​(3 μg / ml, 50 μg / ml, 80 μg / ml) must serve as controls during the operation. After measuring the extract, approximately 50% of the raw materials used are rediscovered. The essence is measured together. The determined and validated values ​​are used as initial values.

[0061] Siberian ginseng-bio-cellulose mask post-treatment Cut the mask soaked in a 3% serum solution into pieces of approximately 1 g each and place approximately 4 g of water (H2O) in a small tube, then immerse for at least 4 hours. During the extraction time, vortex the sample material in the tube. Add the total weight of the mask sample to the total weight of the solvent and record the result.

[0062] Take 200 μl of the solution containing the sample and mix it with 800 μl of methanol / water (50 / 50 v / v). The sample is then measured on HPLC-UV. Ferulic acid is used as a reference standard, as described in Ph.Eur 9.0 / 1419. The content of eleutheroside B can then be calculated. For comparison, the Siberian ginseng solubilizer used is diluted to 3%, similar to a facial mask essence, to determine the eleutheroside B content. The deviation between the essence and the mask can be determined from the determined value in the diluted solubilizer. 57% of the active ingredient used is rediscovered. This value is taken as the initial value.

[0063] Frankincense-bio-cellulose mask post-treatment Cut the mask soaked in a 3% serum solution into pieces of approximately 1 g each, and add approximately 4 g of tetrahydrofuran (THF) to each tube, then immerse for at least 4 hours. During the extraction time, vortex the sample material in the tube. Add the total weight of the mask sample to the total weight of the solvent and record the result.

[0064] Take 1000 μl of the solution containing the sample, centrifuge it first, and then measure it on HPLC-UV.

[0065] The content in the extracted solution can be determined using a four-point calibration curve with 10-200 μg / ml boswellic acid (AKBA) as a reference standard. The essence and solubilizers used are also measured. After measuring the extract, approximately 50% of the raw materials used are rediscovered. The determined and validated values ​​are used as initial values.

[0066] Propolis-bio-cellulose mask post-treatment Cut the mask soaked in a 3% serum solution into pieces of approximately 1 g each and fill each tube with approximately 4 g of water / acetonitrile (90 / 10 v / v) and immerse for at least 4 hours. During the extraction time, vortex the sample material in the tube. Add the total weight of the mask sample to the total weight of the solvent and record the result.

[0067] Take 1000 μl of the solution containing the sample, centrifuge it first, and then measure it on HPLC-UV.

[0068] The content in the extracted solution can be determined using a four-point calibration curve between 2-20 μg / ml of apigenin as a reference standard. The essence and solubilizers used were also measured. After measuring the extract, approximately 66% of the raw materials used were rediscovered. The determined and validated values ​​were used as initial values.

[0069] The measurement data of solubilizers in the face mask are shown below:

[0070]

[0071]

[0072] Measurement data shows that the concentration of raw materials used must be considered because a mass balance occurs due to diffusion. The solubilizers in the mask remain stable, and the liquid (serum) surrounding the mask also remains stable with the solubilizers. The stability of the solubilizers in the mask is guaranteed for at least 12 months starting from storage at 40°C.

Claims

1. A topically applicable composition selected from creams, lotions, emulsions, serums, gels, drops, lotions, balms, fluids, ointments, masks, and / or foams, wherein the composition has one or more microparticle solubilizers of a lipophilic active ingredient selected from plant extracts, plant extracts, plant parts, phytothenic agents, resins, enzymes, vitamins, proteins, algae, functional active substances, and / or coenzymes, as well as mixtures and combinations thereof.

2. The composition according to claim 1, wherein the plant extract, plant extract, or phytotherapy agent is derived from evening primrose (Oenothera biennis), crape myrtle (Cardiospermum halicacabum), pansy (Viola tricolor), horsetail (Equisetum arvense), German chamomile (Matricaria recutita), witch hazel (Hamamelis virginiana), Mahonia aquifolium, birch (Betula pendula), ylang-ylang, Siberian ginseng (Eleutherococcus senticosus), shea butter (avocado oil), turmeric (Curcuma langa), narrow-leaved lavender (Lavandula angustifolia), hypericum (Hypericum perforatum), chondrus crispus (Chondrus crispus), hops (Humulus lupulus), green tea (Camellia sinensis L.), centella asiatica, mallow (Malva oleracea). sylvestris, mosquito grass (Filipendula ulmaria), calendula officinalis L., red clover (Trifolium pratense).

3. The composition according to claim 1, wherein the enzyme, protein or coenzyme is lipase, cellulase, amylase, protease, collagen, acetyl hexapeptide-8, pentapeptide-18 and / or coenzyme-10 (Q10).

4. The composition according to claim 1, wherein the resin is frankincense, propolis, or myrrh.

5. The composition according to claim 1, wherein the functional active substance is astaxanthin, resveratrol, pterostilbene, fruit acid, or a substance capable of interacting with the hypoxia-inducible factor (HIF), mTor, p53, GDNF, GLUT1 functional pathways.

6. The composition according to any one of claims 1-5, wherein the solubilizer is a combination of one or more emulsifiers, fat-soluble active ingredients, and adjuvants.

7. The composition according to claim 6, wherein the emulsifier is selected from polysorbate, Lutrol and / or D-α-tocopherol polyethylene glycol 1000 succinate.

8. The composition according to claim 6 or 7, wherein the adjuvant is ethanol, polysorbate and / or glycerin.

9. The composition according to any one of claims 1-8, wherein it contains additional cosmetic or pharmaceutical adjuvants, preferably emulsifiers, stabilizers, preservatives, thickeners and / or binders.

10. The composition according to claim 9, wherein the stabilizer is vitamin C or vitamin D.

11. Use of the composition according to any one of claims 1-10 for cosmetic purposes of caring for and cleansing any skin type.

12. The composition according to any one of claims 1-10, in a method of treating a skin disease.

13. The composition for use according to claim 12, wherein the skin disease is acne, herpes, neurodermatitis, urticaria, erysipelas, burns, or psoriasis.

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