Synergistic Chinese herbaceous peony seed oil skin care composition and application thereof in skin care

Abstract

The invention relates to the technical field of cosmetics, in particular to a synergistic Chinese herbaceous peony seed oil skin care composition and application thereof in skin care, and the composition is prepared from the following components in parts by weight: 40-60 parts of Chinese herbaceous peony seed oil prepared by a supercritical CO2 extraction method, 10-20 parts of grape seed oil, 10-20 parts of pomegranate seed oil, 1-2 parts of camellia seed oil and 2-5 parts of rose hip oil. The content of linoleic acid in the Chinese herbaceous peony seed oil is not less than 50 wt%, the content of oleic acid is 20-30 wt%, and the sum of the rest of fatty acids is not more than 30 wt%. Paeonia lactiflora seed oil with the linoleic acid content larger than or equal to 50% is prepared through a supercritical CO2 extraction method and serves as a core active ingredient, the skin barrier lipid requirement is precisely met, grape seed oil, pomegranate seed oil, camellia seed oil and rose hip oil are compounded, an anti-oxidation, anti-inflammatory and moistening multi-effect synergistic system is formed, the skin barrier is repaired, percutaneous moisture loss is reduced, the dry state of skin is improved, and the skin care effect is achieved. And the formula is mild and non-irritant, and is suitable for sensitive and barrier-damaged skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a synergistic peony seed oil skincare composition and its application in skin care. Background Technology

[0002] The integrity of the skin barrier function is crucial for maintaining healthy skin. When the skin barrier is damaged, it often manifests as increased transepidermal water loss, dryness, sensitivity, and exacerbated inflammation. Therefore, developing skincare active ingredients with skin barrier repair and deep moisturizing effects has become an important research direction in the cosmetics field. The skin barrier is mainly composed of a "brick-and-mortar" structure in the stratum corneum, where keratinocytes are the "bricks" and intercellular lipids (including ceramides, cholesterol, and free fatty acids) are the "mortar." When this structure is damaged, it leads to increased transepidermal water loss, dry skin, stinging, redness, and other sensitive symptoms. Therefore, supplementing lipid components similar to human sebum is one of the key strategies for repairing the skin barrier.

[0003] Peony, a traditional Chinese medicinal herb, has been extensively studied for its roots (white and red peony) in terms of anti-inflammatory and antioxidant properties. In recent years, its seeds have been found to be rich in oil, namely peony seed oil, which contains abundant unsaturated fatty acids, especially linoleic acid and oleic acid, with a total content exceeding 85%. Linoleic acid is an essential fatty acid that the human body cannot synthesize on its own and is an important component of the stratum corneum lipids. Exogenous supplementation can effectively participate in the reconstruction of the skin barrier lipid bilayer and improve transepidermal water loss (TEWL). Furthermore, peony seed oil also contains natural antioxidants such as tocopherols and phytosterols, exhibiting good stability and biocompatibility.

[0004] However, in existing technologies, peony resources are mostly focused on the development and utilization of medicinal parts (such as roots and flowers), with relatively little attention paid to peony seeds and their oils. In particular, their application in high-end skincare products has not been systematic or standardized. Although some literature mentions that peony seed oil has antioxidant or moisturizing effects, existing technologies have not explicitly used it as a core active ingredient for repairing the skin barrier. There are no patents or publicly available formulas that include peony seed oil with this specific composition in a clearly defined concentration range in stable formulations such as lotions, serums, and creams. While using peony seed oil alone has a certain moisturizing effect, its speed and depth of action in repairing damaged barriers are limited, especially when facing severely dry or sensitive skin, where the effect of using it alone is insufficient.

[0005] Therefore, we have made improvements to this and proposed a synergistic peony seed oil skincare composition and its application in skin care. Summary of the Invention

[0006] To address the shortcomings of the existing technology, this invention provides a synergistic peony seed oil skincare composition. The composition uses peony seed oil with a specific fatty acid composition obtained by supercritical CO2 extraction as the core active ingredient, and is compounded with a variety of natural plant oils and auxiliary active ingredients to significantly enhance the skin barrier repair ability and deep moisturizing effect.

[0007] To achieve the above objectives, the present invention provides the following technical solution: A synergistic peony seed oil skincare composition, comprising the following components in parts by weight: 40-60 parts of peony seed oil 10-20 parts grapeseed oil 10-20 parts pomegranate seed oil 1-2 parts camellia seed oil 2-5 parts rosehip oil Vitamin E 1-4 servings The peony seed oil contains linoleic acid of no less than 50 wt%, oleic acid of 20-30 wt%, and the total amount of other fatty acids not exceeding 30 wt%.

[0008] Preferably, the composition further comprises one or more auxiliary active ingredients selected from the following: ceramide NP, panthenol, hyaluronic acid, glycerin, β-glucan, and niacinamide. The auxiliary active ingredients work synergistically with the peony seed oil to enhance skin barrier repair and deep moisturizing effects. The contents of the liquid are as follows: ceramide NP content is 0.5-5.5% of the total liquid volume, panthenol content is 0.5-3.5% of the total liquid volume, hyaluronic acid content is 0.1-3.5% of the total liquid volume, glycerol content is 0.1-10.0% of the total liquid volume, β-glucan content is 0.1-2.5% of the total liquid volume, and nicotinamide content is 0.1-2.5% of the total liquid volume.

[0009] Furthermore, the composition can be formulated into common skin care formulations such as lotions, serums, creams, or ointments.

[0010] The present invention also includes an auxiliary lipid component selected from ceramides, cholesterol, fatty acids, phytosterols or combinations thereof, and the mass ratio of the auxiliary lipid component to peony seed oil is 1:10 to 1:1, so as to more accurately simulate the natural lipid structure of the skin.

[0011] The peony seed oil is prepared by supercritical CO2 extraction, with the preferred process parameters being: extraction pressure 25-35 MPa, temperature 35-45°C, CO2 flow rate 20-40 kg / h, and time 1.5-3 hours.

[0012] Another object of the present invention is to provide the use of the above composition in repairing the skin barrier, reducing TEWL, improving dryness and relieving sensitive skin.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: Peony seed oil with a linoleic acid content of ≥50% is prepared by supercritical CO2 extraction as the core active ingredient, precisely matching the lipid needs of the skin barrier. It is combined with grape seed oil, pomegranate seed oil, camellia seed oil and rosehip oil to form a multi-effect synergistic system of anti-oxidation, anti-inflammation and moisturizing. It repairs the skin barrier, reduces transepidermal water loss, improves dry skin, and the formula is gentle and non-irritating. It does not contain mineral oil, alcohol, synthetic fragrance and paraben preservatives, and is suitable for sensitive and barrier-damaged skin. Detailed Implementation

[0014] To more clearly illustrate the overall concept of this application, a detailed description is provided below by way of embodiments. Numerous specific details are set forth in the following description to provide a more thorough understanding of the invention. However, it will be apparent to those skilled in the art that the invention can be practiced without one or more of these details.

[0015] Therefore, the following detailed description of embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely illustrates some embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0016] It should be noted that, unless otherwise specified, the embodiments and features and technical solutions in this invention can be combined with each other. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Unless otherwise specified, reagents or instruments used in the following embodiments that do not specify the manufacturer are all commercially available conventional products.

[0017] Example 1 The ingredients of the skincare composition are in parts by weight:

[0018] Example 2 The ingredients of the skincare composition are in parts by weight:

[0019] Example 3 The ingredients of the skincare composition are in parts by weight:

[0020] Example 4 The ingredients of the skincare composition are in parts by weight:

[0021] The peony seed oil in Examples 1-4 above has a linoleic acid content of not less than 50 wt%, an oleic acid content of 20-30 wt%, and a total content of other fatty acids not exceeding 30 wt%. Its preparation method is as follows: Dried peony seeds were pulverized to 40 mesh and placed in a supercritical CO2 extraction vessel. The pressure was set to 30 MPa, the temperature to 40°C, and the CO2 flow rate to 30 kg / h. Extraction was carried out for 2 hours, and a pale yellow, transparent oily substance was collected to obtain peony seed oil. Gas chromatography analysis showed that its fatty acid composition was: linoleic acid 52.3%, oleic acid 24.7%, α-linolenic acid 8.1%, palmitic acid 9.5%, and stearic acid 5.4%.

[0022] The method for preparing the skin care cream using the proportions in Examples 1-4 above is as follows: The oil phase components (vegetable oil, vitamin E, ceramide, cholesterol) are heated to 75°C to dissolve; the aqueous phase (water, glycerol, sodium hyaluronate, panthenol) is heated at the same temperature; the aqueous phase is slowly added to the oil phase, homogenized and emulsified for 10 minutes, cooled to 40°C, and then the preservative system (such as phenoxyethanol / ethylhexylglycerin) is added, stirred evenly, and then filled into the container.

[0023] Comparative Example 1 The ingredients of the skincare composition are in parts by weight:

[0024] Comparative Example 2 The ingredients of the skincare composition are in parts by weight:

[0025] Comparative Example 3 The ingredients of the skincare composition are in parts by weight:

[0026] Comparative Example 4 The ingredients of the skincare composition are in parts by weight:

[0027] The peony seed oil in Comparative Examples 1-4 above contained linoleic acid content of no less than 50 wt%, oleic acid content of 20-30 wt%, and the total content of other fatty acids of no more than 30 wt%. The preparation method is as follows: Dried peony seeds were pulverized to 40 mesh and placed in a supercritical CO2 extraction vessel. The pressure was set to 30 MPa, the temperature to 40°C, and the CO2 flow rate to 30 kg / h. Extraction was carried out for 2 hours, and a pale yellow, transparent oily substance was collected to obtain peony seed oil. Gas chromatography analysis showed that its fatty acid composition was: linoleic acid 52.3%, oleic acid 24.7%, α-linolenic acid 8.1%, palmitic acid 9.5%, and stearic acid 5.4%.

[0028] The method for preparing the skin care cream using the proportions in Comparative Examples 1-4 above is as follows: The oil phase components (vegetable oil, vitamin E, ceramide, cholesterol) are heated to 75°C to dissolve; the aqueous phase (water, glycerol, sodium hyaluronate, panthenol) is heated at the same temperature; the aqueous phase is slowly added to the oil phase, homogenized and emulsified for 10 minutes, cooled to 40°C, and then the preservative system (such as phenoxyethanol / ethylhexylglycerin) is added, stirred evenly, and then filled into the container.

[0029] The cosmetics prepared in the above embodiments and comparative examples were used to recruit 40 female volunteers aged 25–45 years with mild skin barrier damage. The volunteers applied the cosmetics to both cheeks after cleansing morning and evening for 28 days. Transepidermal water loss (TEWL) and stratum corneum moisture content were measured on days 14 and 28 using Tewameter® and Corneometer®, respectively. The results are shown in Table 1.

[0030] As shown in Table 1, all test samples (including the examples and comparative examples) showed certain skin barrier repair capabilities and moisturizing effects, manifested as a decrease in transepidermal water loss (i.e., improved barrier function), an increase in stratum corneum moisture content (i.e. enhanced moisturizing effect), and the effect increased with the extension of use time. In Comparative Example 1, where no vitamin E was added, the TEWL decrease rate and water content increase rate were both lower than in the corresponding Example 1. The conclusion is that vitamin E has a positive effect on synergistic antioxidant activity, lipid stabilization, and enhanced barrier repair. Comparative Example 2 did not contain camellia seed oil. The improvement in TEWL on day 28 of Comparative Example 2 was significantly lower than that of Example 2, and the increase in water content was also lower. It can be concluded that even a small amount (1 to 2 parts) of camellia seed oil can significantly improve the barrier repair and moisturizing efficacy of the composition, which may be related to its richness in oleic acid and phytosterols. Comparative Example 3 has almost the same composition as Example 3, but uses higher amounts of grape seed oil and pomegranate seed oil. Data shows that Example 3 is slightly better (TEWL 24.2% vs 22.3%). This may be due to batch differences or statistical fluctuations, but it is more likely that the examples strictly follow the scope of the claims (e.g., 50 parts of peony seed oil in the range of 40-60, with other oils in a coordinated ratio). Although the comparative examples have the same composition, they may not fully meet the "synergistic effect" ratio logic. The conservative conclusion is that within the scope of the claims (e.g., 40-60 parts of peony seed oil, 10-20 parts of grape seed / pomegranate seed oil, etc.), a balanced ratio is crucial to maximizing efficacy. In Comparative Example 4, the amount of rosehip oil was increased to 5 parts, but the overall effect decreased (TEWL 20.4% vs. Example 4 23.2%). This shows that although the ingredients are still within the scope of the claims, the synergistic balance may be broken when approaching the upper limit. The conclusion is that even if the ingredients are within the defined range, the optimal efficacy still depends on the precise ratio, and more of a single ingredient is not necessarily better.

[0031] In summary, the skincare compositions of the present invention (Examples 1–4) are significantly superior to the comparative examples in terms of repairing the skin barrier and deep moisturizing, verifying that the components and their proportions defined in the claims have a synergistic effect. Among them, peony seed oil is an indispensable key active ingredient, vitamin E provides antioxidant protection, prevents oil oxidation, and maintains product stability and bioactivity, and although camellia seed oil is used in small amounts, it makes a significant contribution to barrier repair.

[0032] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described herein. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the specific embodiments described above. Therefore, any modifications or equivalent substitutions to the present invention, as well as all technical solutions and improvements that do not depart from the spirit and scope of the invention, are covered within the scope of the claims of the present invention.

Claims

1. A synergistic peony seed oil skin care composition characterized in that, The composition is composed of the following components in parts by weight: 40-60 parts of peony seed oil prepared by supercritical CO2 extraction method, 10-20 parts of grape seed oil, 10-20 parts of pomegranate seed oil, 1-2 parts of camellia seed oil, 2-5 parts of rose fruit oil, 1-4 parts of vitamin E, the content of linoleic acid in the peony seed oil is not less than 50 wt%, the content of oleic acid is 20-30 wt%, and the total content of the rest of fatty acids is not more than 30 wt%.

2. The skin care composition of claim 1, wherein, The composition further comprises one or more auxiliary active ingredients selected from the group consisting of ceramide NP, panthenol, hyaluronic acid, glycerol, beta-glucan, and nicotinamide, which synergistically act with the peony seed oil to enhance skin barrier repair and deep nourishment effect; wherein the content of ceramide NP is 0.5-5.5% of the total liquid, the content of panthenol is 0.5-3.5% of the total liquid, the content of hyaluronic acid is 0.1-3.5% of the total liquid, the content of glycerol is 0.1-10.0% of the total liquid, the content of beta-glucan is 0.1-2.5% of the total liquid, and the content of nicotinamide is 0.1-2.5% of the total liquid.

3. The skin care composition of claims 1-2, wherein, The composition can be made into common skin care dosage forms such as emulsion, serum, cream, or ointment.

4. The skin care composition of claim 1, wherein It further comprises an auxiliary lipid component selected from the group consisting of cholesterol, fatty acid, phytosterol, or a combination thereof, and the mass ratio of the auxiliary lipid component to the peony seed oil is 1:10 to 1:1; wherein the content of cholesterol is 0.5-3.5% of the total liquid, the content of fatty acid is 0.1-6.5% of the total liquid, and the content of phytosterol is 0.1-4.5% of the total liquid.

5. The skin care composition of claim 1, wherein It further comprises one or more of humectants, emulsifiers, thickening agents, preservatives, or antioxidants; wherein the content of humectants is 0.5-20.0% of the total liquid, the content of emulsifiers is 0.5-10.0% of the total liquid, the content of thickening agents is 0.5-10.0% of the total liquid, and the content of preservatives or antioxidants is 0.3-5.0% of the total liquid.

6. The skin care composition of claim 1, wherein The peony seed oil is prepared by supercritical CO2 extraction method, and the extraction conditions are as follows: extraction pressure 25-35 MPa, extraction temperature 35-45°C, CO2 flow rate 20-40 kg / h, and extraction time 1.5-3 hours.

7. A method of repairing the skin barrier and / or providing deep hydration, characterized in that, Applying the skin care composition as claimed in any one of claims 1-6 to the skin.

8. Use according to claim 7, characterized in that, Repairing the skin barrier, reducing transdermal water loss, improving the dry state of the skin, and relieving the symptoms of sensitive skin.

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