Application of 6-(substituted pyridine-4-yl)-5-(substituted phenyl)-1, 2, 4-triazine compound in preparation of antidepressant drugs
By developing 6-(substituted pyridin-4-yl)-5-(substituted phenyl)-1,2,4-triazine derivatives as A2AR antagonists, the problems of delayed onset and side effects of existing antidepressants have been solved, and significant antidepressant effects have been achieved in mouse models, demonstrating broad prospects for antidepressant treatment.
CN121534062APending Publication Date: 2026-02-17RES INST OF CHEM DEFENSE PLA ACAD OF MILITARY SCI
Patent Information
- Application Number
- CN202511934865.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-22
- Publication Date
- 2026-02-17
Smart Images
Figure CN121534062A_ABST
Abstract
The invention relates to the technical field of medicines, and particularly provides application of a 6-(substituted pyridine-4-yl)-5-(substituted phenyl)-1, 2, 4-triazine compound derivative in preparation of an antidepressant drug. A cell experiment proves that the 6-(substituted pyridine-4-yl)-5-(substituted phenyl)-1, 2, 4-triazine compound is an antagonist of an adenosine 2A receptor, and a plurality of animal model experiments prove that the 6-(substituted pyridine-4-yl)-5-(substituted phenyl)-1, 2, 4-triazine compound has a relatively good treatment effect on a plurality of depression models. The compound has an application prospect of being used as an anti-depression treatment drug.
Need to check novelty before this filing date? Find Prior Art
Citation Information
Patent Citations
1,2,4-triazine-4-amine derivatives
CN102822150A
Benzenesulfonamide derivative and application thereof in preparation of antidepressant drug
CN120865123A
Application of carboline compound in preparation of antidepressant drug
CN120899704A
Application of adenosine A2a / A2b receptor dual antagonist in preparation of antidepressant drug
CN121489952A