High-purity phenoxyethanol purification equipment for biological medicine preparation

Abstract

The invention relates to the technical field of biological medicine chemical industry, in particular to high-purity phenoxyethanol purification equipment for biological medicine preparation, which comprises a raw material preheating tank and an auxiliary preheating mechanism, and the auxiliary preheating mechanism comprises a stirring assembly, a heat conduction oil conveying unit, a heat conduction oil input pipe, a heat conduction oil output pipe and a spiral heat exchange pipe. Through cooperation of a heat conduction oil conveying unit, a heat conduction oil input pipe and a heat conduction oil output pipe, a spiral heat exchange pipe immersed in a raw material in a raw material preheating tank provides a stable and high-temperature heat source for the raw material, the raw material in the raw material preheating tank is preheated, and through arrangement of a stirring assembly, the raw material in the raw material preheating tank is stirred; by the adoption of the structure, the raw materials are preheated through high-temperature products extracted from the refining tower, meanwhile, heat conduction oil in the spiral heat exchange pipe is used for auxiliary preheating, and the preheating effect on the raw materials is better.

Description

Technical Field

[0001] This invention relates to the field of biopharmaceutical and chemical technology, and in particular to a high-purity phenoxyethanol purification device for biopharmaceutical preparation. Background Technology

[0002] Phenoxyethanol, as a highly effective and broad-spectrum preservative, plays an irreplaceable role in the biopharmaceutical field. It is widely used in vaccines, injections, eye drops, and various topical medications to inhibit microbial growth and ensure the stability and safety of the drugs within their shelf life.

[0003] In the prior art, such as the high-purity phenoxyethanol purification equipment disclosed in patent document CN218146432U, the purity of phenoxyethanol can be effectively improved through a dual-tower process including a coarse separation tower and a refining tower. This equipment uses the coarse separation tower to remove light components (such as phenol) and heavy components, and collects the crude product from the side stream, which then enters the refining tower for distillation and concentration, ultimately obtaining a high-purity product. This design simplifies the refining tower structure (only a stripping section is included), eliminating some equipment and reducing investment and energy consumption to a certain extent.

[0004] However, in practical applications, existing high-purity phenoxyethanol purification equipment only uses the high-temperature product taken from the bottom of the refining tower to preheat the raw materials, which is not an ideal preheating effect. Summary of the Invention

[0005] The purpose of this invention is to provide a high-purity phenoxyethanol purification device for biopharmaceutical preparation, which aims to solve the technical problem that the existing high-purity phenoxyethanol purification devices, in practical applications, only use the high-temperature product taken from the bottom of the purification tower to preheat the raw materials, resulting in an unsatisfactory preheating effect.

[0006] To achieve the above objectives, the present invention provides a high-purity phenoxyethanol purification device for biopharmaceutical preparation, comprising a raw material preheating tank and an auxiliary preheating mechanism. The bottom of the raw material preheating tank is provided with a discharge port, and the bottom of the discharge port is connected to the feed port of the coarse separation tower through a pumping system. The shell of the raw material preheating tank is provided with a jacket, the bottom of the jacket is provided with a feed pipe, and the top of the jacket is provided with a discharge pipe. Both the feed pipe and the discharge pipe are connected to the discharge port of the purification tower through a pumping system. The auxiliary preheating mechanism includes a stirring assembly, a heat transfer oil conveying unit, a heat transfer oil inlet pipe, a heat transfer oil outlet pipe, and a spiral heat exchanger tube. A raw material inlet is located on the side of the top of the raw material preheating tank. The stirring assembly is installed at the center of the top of the raw material preheating tank. The outlet pipe of the stirring assembly is located inside the raw material preheating tank. The heat transfer oil inlet pipe and the heat transfer oil outlet pipe are respectively located on both sides of the raw material preheating tank, at the top and bottom of the raw material preheating tank. Both the heat transfer oil inlet pipe and the heat transfer oil outlet pipe are connected to the heat transfer oil conveying unit via pipes. A spiral heat exchanger tube is installed between the end of the heat transfer oil inlet pipe located inside the raw material preheating tank and the end of the heat transfer oil outlet pipe located inside the raw material preheating tank. The spiral heat exchanger tube is located outside the outlet end of the stirring assembly.

[0007] The stirring assembly includes a mounting bracket, a drive motor, a stirring shaft, and multiple stirring blades. The mounting bracket is fixed to the top of the raw material preheating tank. The drive motor is mounted on the mounting bracket. The output end of the drive motor is provided with the stirring shaft. Multiple stirring blades are provided at one end of the stirring shaft located inside the raw material preheating tank.

[0008] The mounting bracket includes a mounting plate and four legs. The drive motor is mounted on the upper surface of the mounting plate, and the legs are provided at the four bottom feet of the mounting plate. The legs are fixed to the top of the raw material preheating tank.

[0009] The auxiliary preheating mechanism further includes two auxiliary heat exchange tubes. Two auxiliary heat exchange tubes are also provided between one end of the heat transfer oil inlet pipe located inside the raw material preheating tank and the other end of the heat transfer oil outlet pipe located inside the raw material preheating tank. The two auxiliary heat exchange tubes are symmetrically arranged on both sides of the outside of the spiral heat exchange tube.

[0010] Each of the auxiliary heat exchange tubes is arranged in a disc-shaped structure.

[0011] The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation further includes a first support member. The first support member is provided on the side of the top of the spiral heat exchange tube away from the heat transfer oil inlet pipe and on the side of the bottom of the spiral heat exchange tube away from the heat transfer oil outlet pipe. The first support member is used to provide auxiliary support for the spiral heat exchange tube.

[0012] Each of the first support members includes a support rod, a fixing block, and a support block. One end of the support rod is fixedly provided with the fixing block, and the other end of the support rod is fixedly provided with the support block. The fixing block is connected to the inner wall of the raw material preheating tank, and the support block abuts against the outer wall of the spiral heat exchange tube.

[0013] This invention discloses a high-purity phenoxyethanol purification device for biopharmaceutical preparation, comprising a raw material preheating tank and an auxiliary preheating mechanism. The auxiliary preheating mechanism includes a stirring assembly, a heat transfer oil conveying unit, a heat transfer oil inlet pipe, a heat transfer oil outlet pipe, and a spiral heat exchanger tube. Through the cooperation of the heat transfer oil conveying unit, the heat transfer oil inlet pipe, and the heat transfer oil outlet pipe, the spiral heat exchanger tube, immersed in the raw material in the raw material preheating tank, provides a stable, high-temperature heat source to the raw material, preheating it. Furthermore, the stirring assembly stirs the raw material in the preheating tank, ensuring uniform heating. Using this structure, while preheating the raw material using the high-temperature product from the refining tower, the auxiliary preheating using the heat transfer oil in the spiral heat exchanger tube results in a better preheating effect. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the high-purity phenoxyethanol purification equipment for biopharmaceutical preparation according to the first embodiment of the present invention.

[0016] Figure 2 This is a schematic diagram of the internal structure of the raw material preheating tank in the first embodiment of the present invention.

[0017] Figure 3 This is a schematic diagram of the auxiliary preheating mechanism in the first embodiment of the present invention.

[0018] Figure 4 This is a schematic diagram of the stirring assembly in the first embodiment of the present invention.

[0019] Figure 5 This is a schematic diagram of the auxiliary preheating mechanism in the second embodiment of the present invention.

[0020] Figure 6 This invention provides Figure 5 A magnified view of the local structure at point A.

[0021] 101-Raw material preheating tank, 102-Heat transfer oil conveying unit, 103-Heat transfer oil inlet pipe, 104-Heat transfer oil outlet pipe, 105-Spiral heat exchanger tube, 106-Drive motor, 107-Stirring shaft, 108-Stirring blade, 109-Mounting plate, 110-Support leg, 111-Discharge port, 112-Jacket, 113-Feed pipe, 114-Discharge pipe, 115-Raw material inlet, 116-Auxiliary heat exchanger tube, 201-Support rod, 202-Fixing block, 203-Support block, 204-Connecting rod, 205-Mounting block, 206-Arc-shaped clamping plate. Detailed Implementation

[0022] Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0023] First embodiment: Please see Figures 1 to 4 ,in Figure 1 This is a schematic diagram of the high-purity phenoxyethanol purification equipment for biopharmaceutical preparation according to the first embodiment. Figure 2 This is a schematic diagram of the internal structure of the raw material preheating tank in the first embodiment. Figure 3 This is a schematic diagram of the auxiliary preheating mechanism in the first embodiment. Figure 4 This is a schematic diagram of the stirring assembly in the first embodiment.

[0024] This invention provides a high-purity phenoxyethanol purification device for biopharmaceutical preparation: it includes a raw material preheating tank 101 and an auxiliary preheating mechanism. The auxiliary preheating mechanism includes a stirring assembly, a heat transfer oil conveying unit 102, a heat transfer oil inlet pipe 103, a heat transfer oil outlet pipe 104, and a spiral heat exchanger tube 105. The stirring assembly includes a mounting bracket, a drive motor 106, a stirring shaft 107, and multiple stirring blades 108. The mounting bracket includes a mounting plate 109 and four support legs 110. This solution solves the problem that existing high-purity phenoxyethanol purification equipment, in practical applications, relies solely on the high-temperature product collected from the bottom of the refining tower for raw material preheating, resulting in insufficient preheating effect. Therefore, the aforementioned solution can be applied to the structure of a high-purity phenoxyethanol purification device for biopharmaceutical preparation.

[0025] In this specific embodiment, the bottom of the raw material preheating tank 101 is provided with a discharge port 111. The bottom of the discharge port 111 is connected to the feed port of the coarse separation tower via a pumping system. A jacket 112 is provided on the shell of the raw material preheating tank 101. A feed pipe 113 is provided at the bottom of the jacket 112, and a discharge pipe 114 is provided at the top of the jacket 112. Both the feed pipe 113 and the discharge pipe 114 are connected to the discharge port of the refining tower via a pumping system. The equipment utilizes a coarse separation tower to remove light components (such as phenol) and heavy components, and collects the crude product from the side stream. The crude product then enters a refining tower for distillation and concentration, ultimately obtaining a high-purity product (this is the content disclosed in the prior art). Furthermore, through the arrangement of the jacket 112, the feed pipe 113, and the discharge pipe 114, the heat from the high-temperature phenoxyethanol product at the bottom of the refining tower is used to preheat the raw materials in the raw material preheating tank 101, thereby reducing the energy consumption of the entire purification equipment.

[0026] The raw material preheating tank 101 has a raw material inlet 115 on its top side. A stirring assembly is installed at the center of the top of the raw material preheating tank 101. The output pipe of the stirring assembly is located inside the raw material preheating tank 101. A heat transfer oil inlet pipe 103 and a heat transfer oil outlet pipe 104 are respectively located on both sides of the raw material preheating tank 101, at the top and bottom of the raw material preheating tank 101. Both the heat transfer oil inlet pipe 103 and the heat transfer oil outlet pipe 104 are connected to the heat transfer oil conveying unit 102 via pipes. One end of the heat transfer oil inlet pipe 103 inside the raw material preheating tank 101 is connected to the end of the heat transfer oil outlet pipe 104 inside the raw material preheating tank 101. The spiral heat exchange tube 105 is arranged at one end of the inner part of the stirring assembly. The spiral heat exchange tube 105 is located outside the output end of the stirring assembly. Through the cooperation of the heat transfer oil conveying unit 102, the heat transfer oil inlet pipe 103 and the heat transfer oil outlet pipe 104, the spiral heat exchange tube 105, which is immersed in the raw material preheating tank 101, provides a stable and high-temperature heat source to the raw material, preheating the raw material in the raw material preheating tank 101. The stirring assembly is used to stir the raw material in the raw material preheating tank 101 to ensure uniform heating of the raw material. With the above structure, while the high-temperature product from the refining tower is used to preheat the raw material, the heat transfer oil in the spiral heat exchange tube 105 is used for auxiliary preheating, resulting in a better preheating effect of the raw material.

[0027] Secondly, the mounting bracket is fixed to the top of the raw material preheating tank 101, and the drive motor 106 is mounted on the mounting bracket. The output end of the drive motor 106 is provided with the stirring shaft 107. The stirring shaft 107 is provided with a plurality of stirring blades 108 at one end inside the raw material preheating tank 101. When the drive motor 106 is started, the stirring shaft 107 drives the plurality of stirring blades 108 to rotate inside the raw material preheating tank 101, thereby stirring the raw materials in the raw material preheating tank 101.

[0028] Meanwhile, the drive motor 106 is installed on the upper surface of the mounting plate 109, and the four bottom feet of the mounting plate 109 are provided with the support feet 110. The support feet 110 are fixed to the top of the raw material preheating tank 101. The support feet 110 are fixed to the top of the raw material preheating tank 101 with screws, thereby completing the installation of the mounting bracket.

[0029] In addition, the auxiliary preheating mechanism also includes two auxiliary heat exchange tubes 116. Two auxiliary heat exchange tubes 116 are also provided between one end of the heat transfer oil inlet pipe 103 located inside the raw material preheating tank 101 and the other end of the heat transfer oil outlet pipe 104 located inside the raw material preheating tank 101. The two auxiliary heat exchange tubes 116 are symmetrically arranged on both sides of the outside of the spiral heat exchange tube 105. By setting the two auxiliary heat exchange tubes 116, the preheating effect of the raw material in the raw material preheating tank 101 is better. Moreover, each auxiliary heat exchange tube 116 is arranged in a disc-shaped structure, which further improves the preheating effect of the raw material.

[0030] When using the high-purity phenoxyethanol purification equipment for biopharmaceutical preparation according to this embodiment, the heat from the high-temperature phenoxyethanol product at the bottom of the refining tower is used to preheat the raw materials in the raw material preheating tank 101, thereby reducing the energy consumption of the entire purification equipment. Furthermore, the heat transfer oil conveying unit 102, the heat transfer oil inlet pipe 103, and the heat transfer oil outlet pipe 104 work together to provide a stable, high-temperature heat source to the raw materials immersed in the raw material preheating tank 101 via the spiral heat exchange tube 105, preheating the raw materials in the raw material preheating tank 101. The stirring assembly further agitates the raw materials in the raw material preheating tank 101, ensuring uniform heating. With this structure, while the high-temperature product from the refining tower preheats the raw materials, the heat transfer oil in the spiral heat exchange tube 105 provides auxiliary preheating, resulting in a better preheating effect.

[0031] Second embodiment: Based on the first embodiment, please refer to Figure 5 and Figure 6 , Figure 5 This is a schematic diagram of the auxiliary preheating mechanism in the second embodiment. Figure 6 for Figure 5 A magnified view of the local structure at point A.

[0032] The present invention provides a high-purity phenoxyethanol purification device for biopharmaceutical preparation, which further includes a first support component, each of which includes a support rod 201, a fixing block 202 and a support block 203.

[0033] In this specific embodiment, the first support member is provided on both the top end of the spiral heat exchange tube 105 away from the heat transfer oil inlet pipe 103 and the bottom end of the spiral heat exchange tube 105 away from the heat transfer oil outlet end. The first support member is used to provide auxiliary support for the spiral heat exchange tube 105. By providing the first support member, the structure of the spiral heat exchange tube 105 installed in the raw material preheating tank 101 is more stable.

[0034] The support rod 201 has a fixed block 202 at one end and a support block 203 at the other end. The fixed block 202 is connected to the inner wall of the raw material preheating tank 101, and the support block 203 abuts against the outer wall of the spiral heat exchange tube 105. Both the fixed block 202 and the support block 203 are fixedly connected to the support rod 201. The first support component is manufactured using an integral molding technology, resulting in a more robust structure.

[0035] Secondly, each of the auxiliary heat exchange tubes 116 is provided with a second support member. The end of the second support member away from the corresponding auxiliary heat exchange tube 116 is connected to the inner wall of the raw material preheating tank 101. The second support member supports the auxiliary heat exchange tube 116, making the structure of the auxiliary heat exchange tube 116 installed in the raw material preheating tank 101 more stable.

[0036] In addition, each of the second support members includes a connecting rod 204, a mounting block 205, and an arc-shaped clamping plate 206. The mounting block 205 is fixedly installed at one end of the connecting rod 204, and the arc-shaped clamping plate 206 is fixedly installed at the other end of the connecting rod 204. The mounting block 205 is connected to the inner wall of the raw material preheating tank 101, and the arc-shaped clamping plate is clamped to the outside of the auxiliary heat exchange tube 116.

[0037] When using the high-purity phenoxyethanol purification equipment for biopharmaceutical preparation according to this embodiment, the first support makes the structure of the spiral heat exchange tube 105 installed in the raw material preheating tank 101 more stable. The second support supports the auxiliary heat exchange tube 116, making the structure of the auxiliary heat exchange tube 116 installed in the raw material preheating tank 101 more stable.

[0038] The above description discloses only one preferred embodiment of the present invention, and should not be construed as limiting the scope of the present invention. Those skilled in the art will understand that all or part of the processes of the above embodiments can be implemented, and equivalent changes made in accordance with the claims of the present invention are still within the scope of the invention.

Claims

1. A high-purity phenoxyethanol purification device for biopharmaceutical preparation, comprising a raw material preheating tank, wherein a discharge port is provided at the bottom of the raw material preheating tank, the bottom of the discharge port is connected to the inlet of a coarse separation tower via a pumping system, a jacket is provided on the shell of the raw material preheating tank, an inlet pipe is provided at the bottom of the jacket, and an outlet pipe is provided at the top of the jacket, wherein both the inlet pipe and the outlet pipe are connected to the outlet of a purification tower via a pumping system, characterized in that, It also includes an auxiliary preheating mechanism; The auxiliary preheating mechanism includes a stirring assembly, a heat transfer oil conveying unit, a heat transfer oil inlet pipe, a heat transfer oil outlet pipe, and a spiral heat exchanger tube. A raw material inlet is located on the side of the top of the raw material preheating tank. The stirring assembly is installed at the center of the top of the raw material preheating tank. The outlet pipe of the stirring assembly is located inside the raw material preheating tank. The heat transfer oil inlet pipe and the heat transfer oil outlet pipe are respectively located on both sides of the raw material preheating tank, at the top and bottom of the raw material preheating tank. Both the heat transfer oil inlet pipe and the heat transfer oil outlet pipe are connected to the heat transfer oil conveying unit via pipes. A spiral heat exchanger tube is installed between the end of the heat transfer oil inlet pipe located inside the raw material preheating tank and the end of the heat transfer oil outlet pipe located inside the raw material preheating tank. The spiral heat exchanger tube is located outside the outlet end of the stirring assembly.

2. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 1, characterized in that, The stirring assembly includes a mounting bracket, a drive motor, a stirring shaft, and multiple stirring blades. The mounting bracket is fixed to the top of the raw material preheating tank. The drive motor is mounted on the mounting bracket. The output end of the drive motor is provided with the stirring shaft. Multiple stirring blades are provided at one end of the stirring shaft located inside the raw material preheating tank.

3. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 2, characterized in that, The mounting bracket includes a mounting plate and four legs. The drive motor is mounted on the upper surface of the mounting plate, and the legs are provided at the four bottom feet of the mounting plate. The legs are fixed to the top of the raw material preheating tank.

4. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 1, characterized in that, The auxiliary preheating mechanism also includes two auxiliary heat exchange tubes. Two auxiliary heat exchange tubes are also provided between the end of the heat transfer oil inlet pipe located inside the raw material preheating tank and the end of the heat transfer oil outlet pipe located inside the raw material preheating tank. The two auxiliary heat exchange tubes are symmetrically arranged on both sides of the outside of the spiral heat exchange tube.

5. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 4, characterized in that, Each of the auxiliary heat exchange tubes is arranged in a disc-shaped structure.

6. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 5, characterized in that, The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation also includes a first support member. The first support member is provided on the side of the top of the spiral heat exchange tube away from the heat transfer oil inlet pipe and on the side of the bottom of the spiral heat exchange tube away from the heat transfer oil outlet pipe. The first support member is used to provide auxiliary support for the spiral heat exchange tube.

7. The high-purity phenoxyethanol purification equipment for biopharmaceutical preparation as described in claim 6, characterized in that, Each of the first support members includes a support rod, a fixing block, and a support block. The fixing block is fixedly installed at one end of the support rod, and the support block is fixedly installed at the other end of the support rod. The fixing block is connected to the inner wall of the raw material preheating tank, and the support block abuts against the outer wall of the spiral heat exchange tube.

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