Composite stirring crystallization equipment for production of macloxvir

Abstract

The invention provides composite stirring crystallization equipment for producing macloxvir, and belongs to the technical field of crystallization stirring equipment. Comprising a stirring tank, and a main stirring structure is arranged in the stirring tank. Through the main stirring structure and the rotating speed adjusting structure, a plurality of large-size main shearing wheels serve as main stirrers and are responsible for macroscopic circulation of a tank body to prevent the local saturation from being too high or too low, and a plurality of small-size small shearing wheels are arranged below a feeding hopper; when the rotating speed is high, seed crystals or anti-solvents added during processing can be quickly dispersed, so that the seed crystals or the anti-solvents are uniformly nucleated, or overlarge crystal clusters are crushed, and through the cooperation of the two structures, on the premise of sufficient mixing, nucleation or non-uniform growth caused by insufficient mixing of a single stirrer can be avoided; according to the method, the problems of crystal breakage or excessive secondary nucleation caused by excessive shearing or too strong shearing are solved, rapid and uniform dispersion of the seed crystal during blanking can be ensured, and controllable stirring and shearing are provided at a specific crystallization stage and during anti-solvent addition, so that uniform precipitation is promoted.

Description

Technical Field

[0001] This invention relates to the field of crystallization stirring equipment, and in particular to a composite stirring crystallization device for the production of mabaloxavir. Background Technology

[0002] Composite stirring crystallization equipment is a key process device specifically used in the pharmaceutical and chemical industries for solution crystallization (or crystallization) operations. It typically refers to a specially designed, combined, or multifunctional stirring system within a crystallization vessel (reaction vessel) to optimize mass transfer, heat transfer, and mixing uniformity during the crystallization process, and to precisely control crystal nucleation, growth, and final product characteristics (such as crystal form, particle size distribution, morphology, and purity). In the production of active pharmaceutical ingredients such as mabaloxavir, it is used to precipitate high-purity active drug component crystals from reaction solutions or refining solutions.

[0003] Currently, in the production of high-end active pharmaceutical ingredients such as mabaloxavir, stirred crystallization is a critical step that determines the final product's crystal form, particle size distribution, purity, and yield. This process places extremely high demands on the mixing efficiency, shear force control, and equipment cleaning and maintenance of the stirring equipment. However, existing stirring equipment used for such precision crystallization processes typically suffers from the following significant drawbacks: traditional stirred crystallization equipment often employs a single type of stirrer (such as anchor type, paddle type, or single turbine type). This design struggles to simultaneously meet the needs of different process stages. When adding seed crystals or antisolvents, extremely strong local shear force and rapid dispersion are required to ensure instantaneous uniform distribution of the seed crystals or rapid mixing of the antisolvent, preventing excessive local supersaturation that could lead to explosive nucleation or uneven nucleation. Furthermore, during crystal growth and maturation, relatively gentle circulation and lower shear force are needed to prevent excessive crystal breakage and secondary nucleation. Existing equipment typically offers only a limited number of fixed speed settings, lacking precision and convenience, making it difficult to accurately match the fine requirements of stirring dynamics at different crystallization stages. This results in the inability to provide the most suitable stirring conditions at the optimal moment. Common cleaning methods in existing equipment (such as fixed cleaning ball spraying, manual cleaning with detachable stirrers, or simple built-in scrapers) are significantly inadequate. There is a lack of a self-cleaning mechanism that can completely isolate the equipment during production, automatically deploy and efficiently operate during cleaning, and not interfere with normal stirring. Therefore, this application provides a composite stirring crystallization device for mabaloxavir production to meet these requirements. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a composite stirring crystallization device for the production of mabaloxavir to solve the problems of existing mixing and shear imbalance, fixed stirring speed and inability to self-clean.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: A composite stirring crystallization device for the production of mabaloxavir includes a stirring tank, a main stirring structure is provided inside the stirring tank, a speed adjustment structure is provided outside the main stirring structure, and self-cleaning structures are provided on both sides of the stirring tank. The speed adjustment structure includes a load-bearing block, a receiving sleeve, a clamping plate, a telescopic cylinder, a telescopic rod, a lifting plate, a first receiving plate, and a base. The base is fixedly installed at the bottom of the mixing tank. The first receiving plate is fixedly installed on the top of the base. The load-bearing block is fixedly installed in the middle of the top of the first receiving plate. The receiving sleeve is fixedly installed on the top of the load-bearing block. The clamping plate is fixedly installed inside the receiving sleeve. The telescopic cylinder is fixedly installed on the top of the clamping plate. The telescopic rod is movably sleeved on the top of the telescopic cylinder. The lifting plate is fixedly installed on the top of the telescopic rod. The speed adjustment structure further includes a first connecting column, a hollow sleeve, pulleys, a hexagonal rotating rod, a small shearing wheel, a small gear, a rotating sleeve, and an auxiliary shearing wheel. The first connecting column is fixedly installed on both sides of the top of the lifting plate. A hollow sleeve is fixedly installed on the top of the first connecting column. Pulleys are movably fitted onto the surface of the hollow sleeve. Hexagonal rotating rods are fixedly installed on both the upper and lower sides of the pulleys. Small shearing wheels are fixedly fitted onto the outer surface of the hexagonal rotating rods. A small gear is fixedly fitted onto the top of the outer surface of the hexagonal rotating rod. A rotating sleeve is fixedly installed at the bottom of the hexagonal rotating rod. An auxiliary shearing wheel is fixedly fitted onto the outer surface of the rotating sleeve.

[0006] The main stirring structure includes a first motor support, a first servo motor, and a first motor shaft. The first servo motor is fixedly sleeved in the inner cavity of the first motor support, and the first motor shaft is fixedly sleeved at one end of the output shaft of the first servo motor.

[0007] The main stirring structure also includes a multi-size gear set, a main shear wheel, and a chassis. The multi-size gear set is fixedly sleeved on the outer surface of the first motor shaft. Multiple main shear wheels are fixedly sleeved on the lower surface of the outer surface of the first motor shaft. The chassis is fixedly installed at the bottom end of the first motor shaft.

[0008] The speed adjustment structure further includes a second receiving plate, a receiving column, a hollow groove, a clamping plate, and a translation block. The second receiving plate is movably sleeved on the bottom of the rotating sleeve. A receiving column is fixedly installed on the bottom of the second receiving plate. A translation block is fixedly installed on the bottom of the receiving column. Clamping plates are fixedly installed on both sides of the translation block. The clamping plates are movably clamped inside the hollow groove. The hollow groove is formed on the outer surface of the first receiving plate.

[0009] The speed adjustment structure also includes a second connecting column, an arc-shaped groove, a rotating disk, a second motor shaft, a second servo motor, a second motor support base, and a load-bearing column. The second connecting column is fixedly installed at the bottom of the translation block and is movably engaged inside the arc-shaped groove. The arc-shaped groove is formed on the surface of the rotating disk. The second motor shaft is fixedly sleeved in the inner cavity of the rotating disk. The second motor shaft is fixedly installed at one end of the output shaft of the second servo motor. The second motor support base is fixedly sleeved on the outer surface of the second servo motor. The load-bearing column is fixedly installed at the bottom of the first receiving disk.

[0010] The self-cleaning structure includes a rotating sleeve, a fixed column, a rotating gear, an inner ring gear, a connecting rod, a locking pin, and a working box. The rotating sleeve is fixedly sleeved on one side of the outer surface of the first motor shaft. Fixed columns are movably sleeved on both sides of the rotating sleeve. A rotating gear is fixedly sleeved on the bottom of the outer surface of the fixed column. An inner ring gear is meshed on the outer side of the rotating gear. The inner ring gear is fixedly installed inside the upper part of the mixing tank. A connecting rod is fixedly installed on one side of the bottom of the rotating gear. A locking pin is fixedly installed on one side of the connecting rod. The working box is fixedly installed on both sides of the mixing tank.

[0011] The self-cleaning structure also includes a pneumatic cylinder, a pneumatic rod, a push block, a guide rail, a fixed sleeve block, a connecting sleeve rod, a sliding sleeve block, and a folding door. The pneumatic cylinder is fixedly installed inside the work box. A pneumatic rod is movably sleeved at one end of the pneumatic cylinder. A push block is fixedly installed at one end of the pneumatic rod. Fixed sleeve blocks are fixedly installed on both sides of the surface of the push block. A connecting sleeve rod is movably sleeved on the outer surface of the fixed sleeve block. A sliding sleeve block is movably sleeved on one side of the connecting sleeve rod. A folding door is fixedly installed on one side of the sliding sleeve block.

[0012] The self-cleaning structure also includes a pole, a connecting plate, a working block, a gripper, a cleaning roller, and a groove. The pole is fixedly installed on both sides of the top of the push block, and a connecting plate is fixedly installed on one side of the top of the pole. The working block is fixedly engaged in the inner cavity of the connecting plate.

[0013] The self-cleaning structure also includes a gripper, a cleaning roller, and a groove. The gripper is located on one side of the working block, and the cleaning roller is movably engaged in the inner cavity of the gripper. A groove is provided on one side of the cleaning roller, and the groove and the locking post are fully engaged.

[0014] A feed hopper is fixedly installed on one side of the top of the mixing tank, and a discharge pipe is connected to one side of the bottom of the outer surface of the mixing tank.

[0015] Compared with the prior art, the present invention has at least the following beneficial effects: 1. In the above scheme, through the combined design of the main stirring structure and the speed adjustment structure, multiple large-sized main shear wheels act as the main agitators to prevent local oversaturation or undersaturation by ensuring macroscopic circulation within the tank. Meanwhile, multiple small-sized mini shear wheels are positioned below the feed hopper. At high speeds, they can quickly disperse the seed crystals or antisolvents added during processing, enabling uniform nucleation or breaking up excessively large crystal clusters. Through the cooperation of these two structures, under the premise of thorough mixing, the problems of insufficient mixing by a single agitator leading to uneven nucleation or growth, or excessive shearing causing crystal breakage or excessive secondary nucleation, can be avoided. This ensures rapid and uniform dispersion of seed crystals during feeding and provides controllable stirring and shearing during specific crystallization stages when antisolvents are added, promoting uniform precipitation.

[0016] 2. In the above scheme, through the set speed adjustment structure, when the first servo motor starts, it will drive the first motor shaft and the multi-size gear set to rotate. Through the meshing transmission of the multi-size gear set and the small gear, the small gear can drive the bottom small shear wheel and the auxiliary shear wheel to rotate, thus stirring the material. At this time, the telescopic cylinder is activated to lower the lifting plate and the hollow sleeve frame, thereby lowering the small gear, so that the small gear is kept at the same level as the gears below the multi-size gear set. At this time, the second servo motor is activated to rotate the second motor shaft and the rotating disk, thereby moving the second connecting column inside the arc-shaped groove. Since the translation block is limited by the hollow groove, the second connecting column can move from the arc-shaped groove. When the distal end moves to its inner end, the translation block moves inward with the top second receiving plate and the small gear, allowing the small gear to mesh with the gear set below the multi-size gear set. This enables the small gear to drive the bottom small shear wheel and auxiliary shear wheel to adjust the speed in multiple gears. During the nucleation stage of mabalosavirin, the highest speed is used for strong mixing, rapid and uniform dispersion of the seed crystals, and induction of nucleation. During the crystal growth stage, the speed is reduced to weaken the shear force, protect the stable growth of the crystal, and reduce secondary nucleation. During the aging or ripening stage, the speed is adjusted to the lowest gear for gentle stirring, promoting Ostwald ripening and improving particle size distribution. This allows the stirring to meet the multi-stage stirring requirements of the crystallization process.

[0017] 3. In the above scheme, through the self-cleaning structure, when it is necessary to clean the inside of the mixing tank, the pneumatic cylinder is activated to extend and retract the pneumatic rod, thereby extending the fixed sleeve block. At this time, one end of the connecting sleeve rod is squeezed, while the other end moves to both sides with the folding door. At this time, the cleaning roller is pushed out by the push block and the upright rod. After being pushed out, the locking post is inserted into the groove. Then, the working block is activated to release the clamping of the cleaning roller. Then, the first servo motor drives the first motor shaft to rotate, thereby rotating the rotating sleeve rod and the rotating gear. Through the meshing transmission of the rotating gear and the inner ring gear, the rotating gear causes the cleaning roller to rotate, thereby achieving the effect of automatic cleaning of the inside of the mixing tank. After cleaning, the rotating sleeve rod rotates with the rotating gear to the initial position, and then the working block extends to clamp and pull out the cleaning roller. The folding door closes automatically, thereby achieving the effect of automatic cleaning of the inside of the mixing tank. Moreover, the cleaning component is completely isolated from the working device inside the mixing tank and is not affected. Attached Figure Description

[0018] The accompanying drawings, which are incorporated herein and form part of the specification, illustrate embodiments of the present disclosure and, together with the specification, further serve to explain the principles of the present disclosure and enable those skilled in the art to implement and use the present disclosure.

[0019] Figure 1 A three-dimensional structural diagram of a composite stirring crystallization device for the production of mabaloxavir; Figure 2 A schematic diagram of the internal structure of a three-dimensional stirring crystallization device for the production of mabaloxavir; Figure 3 A schematic diagram of the main stirring structure of a three-dimensional composite stirring crystallization device for the production of mabaloxavir; Figure 4 A schematic diagram of the three-dimensional structure and speed adjustment mechanism of a composite stirring crystallization device for the production of mabaloxavir; Figure 5 A partial explosion diagram of the speed adjustment structure of a three-dimensional composite stirring crystallization device for mabaloxavir production; Figure 6 A schematic diagram of a three-dimensional self-cleaning structure of a composite stirring crystallization device for the production of mabaloxavir; Figure 7 An exploded view of the three-dimensional self-cleaning structure of a composite stirring crystallization device for mabaloxavir production. Figure 8 A three-dimensional structure of a composite stirring crystallization device for the production of mabaloxavir. Figure 7 A magnified view of the structure at point A in the middle; Figure 9 A three-dimensional structure of a composite stirring crystallization device for the production of mabaloxavir. Figure 7 A magnified schematic diagram of the structure at point B in the middle; Figure 10 A three-dimensional structure of a composite stirring crystallization device for the production of mabaloxavir. Figure 7 A magnified schematic diagram of the structure at point C.

[0020] [Figure Labels] 1. Mixing tank; 2. Main mixing structure; 3. Speed ​​adjustment structure; 4. Self-cleaning structure; 5. Feed hopper; 6. Discharge pipe; 21. First motor support base; 22. First servo motor; 23. First motor shaft; 24. Multi-size gear set; 25. Main shearing wheel; 26. Chassis; 31. Load-bearing block; 32. Receiving sleeve plate; 33. Clamping plate; 34. Telescopic cylinder; 35. Telescopic rod; 36. Lifting plate; 37. First connecting column; 38. Hollow sleeve frame; 39. Pulley; 310. Hexagonal rotating rod; 311. Small shearing wheel; 312. Small gear; 313. Rotating sleeve; 314. Auxiliary shearing wheel; 315. Second receiving plate; 316. Receiving column; 317. First receiving plate; 318. Hollow groove; 319. Clamping plate; 320. Translation block; 321. Second connecting column; 322. Arc groove; 323. Rotary disk; 324. Second motor shaft; 325. Second servo motor; 326. Second motor support; 327. Load-bearing column; 328. Base; 41. Rotating sleeve; 42. Fixed column; 43. Rotating gear; 44. Inner ring gear; 46. Connecting rod; 47. Pneumatic cylinder; 48. Pneumatic rod; 49. Push block; 410. Guide rail; 411. Fixed sleeve block; 412. Connecting sleeve; 413. Translation sleeve block; 414. Folding door; 415. Upright pole; 416. Connecting plate; 417. Working block; 418. Grip; 419. Cleaning roller; 420. Groove; 421. Locking post; 422. Working box.

[0021] As shown in the figure, specific structures and devices are labeled in the figure to clearly illustrate the structure of the embodiments of the present invention. However, this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. Those skilled in the art can adjust or modify these devices and environments according to specific needs, and such adjustments or modifications are still included in the scope of the appended claims. Detailed Implementation

[0022] The following is a detailed description of a composite stirring crystallization apparatus for the production of mabaloxavir provided by the present invention, with reference to the accompanying drawings and specific embodiments. It should be noted that, to make the embodiments more detailed, the following embodiments are the best and preferred embodiments; those skilled in the art can also use other alternative methods to implement some known technologies; and the accompanying drawings are only for more specific description of the embodiments and are not intended to specifically limit the present invention.

[0023] Furthermore, spatially related terms such as “below,” “under,” “lower,” “above,” and “upper” are used herein for convenience to describe the relationship of one element or feature to one or more other elements or features, as illustrated in the accompanying drawings. Spatially related terms are intended to cover different orientations in the use or operation of the device other than those depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially related descriptive terms used herein can be interpreted similarly.

[0024] Example 1 like Figure 1 Figure 2 and Figure 4 As shown, an embodiment of the present invention provides a composite stirring crystallization device for the production of mabaloxavir, including a stirring tank 1, a main stirring structure 2 is provided inside the stirring tank 1, a speed adjustment structure 3 is provided outside the main stirring structure 2, a self-cleaning structure 4 is provided on both sides of the stirring tank 1, a feed hopper 5 is fixedly installed on one side of the top of the stirring tank 1, and a discharge pipe 6 is connected to one side of the bottom of the outer surface of the stirring tank 1. The speed adjustment structure 3 includes a load-bearing block 31, a receiving sleeve 32, a clamping plate 33, a telescopic cylinder 34, a telescopic rod 35, a lifting plate 36, a first receiving plate 317, and a base 328. The base 328 is fixedly installed at the bottom of the mixing tank 1. The first receiving plate 317 is fixedly installed on the top of the base 328. The load-bearing block 31 is fixedly installed in the middle of the top of the first receiving plate 317. The receiving sleeve 32 is fixedly installed on the top of the load-bearing block 31. The clamping plate 33 is fixedly installed inside the receiving sleeve 32. The telescopic cylinder 34 is fixedly installed on the top of the clamping plate 33. The telescopic rod 35 is movably sleeved on the top of the telescopic cylinder 34. The lifting plate 36 is fixedly installed on the top of the telescopic rod 35. The speed adjustment structure 3 also includes a first connecting column 37, a hollow sleeve 38, a pulley 39, a hexagonal rotating rod 310, a small shearing wheel 311, a small gear 312, a rotating sleeve 313, and an auxiliary shearing wheel 314. The first connecting column 37 is fixedly installed on both sides of the top of the lifting plate 36. The hollow sleeve 38 is fixedly installed on the top of the first connecting column 37. The pulley 39 is movably fitted on the surface of the hollow sleeve 38. The hexagonal rotating rod 310 is fixedly installed on both the upper and lower sides of the pulley 39. The small shearing wheel 311 is fixedly fitted on the outer surface of the hexagonal rotating rod 310. The small gear 312 is fixedly fitted on the top of the outer surface of the hexagonal rotating rod 310. The rotating sleeve 313 is fixedly installed on the bottom of the hexagonal rotating rod 310. The auxiliary shearing wheel 314 is fixedly fitted on the outer surface of the rotating sleeve 313.

[0025] Example 2 like Figure 3 , Figure 4 and Figure 5 As shown, the main stirring structure 2 includes a first motor support 21, a first servo motor 22, and a first motor shaft 23. The first servo motor 22 is fixedly sleeved in the inner cavity of the first motor support 21, and one end of the output shaft of the first servo motor 22 is fixedly sleeved on the first motor shaft 23. The main stirring structure 2 also includes a multi-size gear set 24, a main shear wheel 25, and a chassis 26. The multi-size gear set 24 is fixedly sleeved above the outer surface of the first motor shaft 23, and multiple main shear wheels 25 are fixedly sleeved below the outer surface of the first motor shaft 23. The chassis 26 is fixedly installed at the bottom end of the first motor shaft 23. The speed adjustment structure 3 also includes a second receiving plate 315, a receiving column 316, a hollow groove 318, a clamping plate 319, and a translation block 320. The second receiving plate 315 is movably sleeved on the bottom of the rotating sleeve 313, and the receiving column 316 is fixedly installed at the bottom of the second receiving plate 315. A translation block 320 is fixedly installed at the bottom of the receiving column 316. Block 320, with clamping plates 319 fixedly installed on both sides of the translation block 320. The clamping plates 319 are movably engaged inside the hollow groove 318. The hollow groove 318 is formed on the outer surface of the first receiving plate 317. The speed adjustment structure 3 also includes a second connecting column 321, an arc groove 322, a rotating disk 323, a second motor shaft 324, a second servo motor 325, a second motor support 326, and a load-bearing column 327. The second connecting column 321 is fixedly installed at the bottom of the translation block 320 and is movably engaged inside the arc groove 322. The arc groove 322 is formed on the surface of the rotating disk 323. The inner cavity of the rotating disk 323 is fixedly fitted with the second motor shaft 324. The second motor shaft 324 is fixedly installed at one end of the output shaft of the second servo motor 325. The outer surface of the second servo motor 325 is fixedly fitted with the second motor support 326. The load-bearing column 327 is fixedly installed at the bottom of the first receiving plate 317.

[0026] When the first servo motor 22 starts, it drives the first motor shaft 23 and the multi-size gear set 24 to rotate. Through the meshing transmission between the multi-size gear set 24 and the small gear 312, the small gear 312 drives the bottom small shear wheel 311 and the auxiliary shear wheel 314 to rotate, thus stirring the material. At this time, the telescopic cylinder 34 is activated, which lowers the lifting plate 36 and the hollow sleeve frame 38, thereby lowering the small gear 312. This ensures that the small gear 312 is level with the gears below the multi-size gear set 24. At this time, the second servo motor 325 is activated to drive the second motor... The shaft 324 and the rotating disk 323 rotate, thereby moving the second connecting column 321 inside the arc-shaped groove 322. Since the translation block 320 is limited by the hollow groove 318, when the second connecting column 321 moves from the far end of the arc-shaped groove 322 to its inner end, the translation block 320 moves inward with the top second receiving disk 315 and the small gear 312, so that the small gear 312 can mesh with the gear set below the multi-size gear set 24, and thus the small gear 312 can perform multi-speed adjustment with the bottom small shear wheel 311 and the auxiliary shear wheel 314.

[0027] Example 3 like Figure 6 — Figure 10As shown, the self-cleaning structure 4 includes a rotating sleeve 41, a fixed column 42, a rotating gear 43, an inner ring gear 44, a connecting rod 46, a locking column 421, and a working box 422. The rotating sleeve 41 is fixedly sleeved on one side of the outer surface of the first motor shaft 23. Fixed columns 42 are movably sleeved on both sides of the rotating sleeve 41. The rotating gear 43 is fixedly sleeved on the bottom of the outer surface of the fixed column 42. The inner ring gear 44 is meshed on the outer side of the rotating gear 43 and is fixedly installed on the mixing tank 1. Inside the upper part, a connecting rod 46 is fixedly installed on one side of the bottom of the rotating gear 43, and a locking post 421 is fixedly installed on one side of the connecting rod 46. The working box 422 is fixedly installed on both sides of the mixing tank 1. The self-cleaning structure 4 also includes a pneumatic cylinder 47, a pneumatic rod 48, a push block 49, a guide rail 410, a fixing sleeve block 411, a connecting sleeve rod 412, a translation sleeve block 413, and a folding door 414. The pneumatic cylinder 47 is fixedly installed inside the working box 422, and one end of the pneumatic cylinder 47 is movably connected to a pneumatic cylinder. The pressure rod 48 has a push block 49 fixedly installed at one end. Fixed sleeve blocks 411 are fixedly installed on both sides of the push block 49. A connecting sleeve rod 412 is movably sleeved on the outer surface of the fixed sleeve block 411. A sliding sleeve block 413 is movably sleeved on one side of the connecting sleeve rod 412. A folding door 414 is fixedly installed on one side of the sliding sleeve block 413. The self-cleaning structure 4 also includes a vertical rod 415, a connecting plate 416, a working block 417, a gripper 418, a cleaning roller 419, and a groove 420. The upright 415 is fixedly installed on both sides of the top of the push block 49. A connecting plate 416 is fixedly installed on one side of the top of the upright 415. The working block 417 is fixedly engaged in the inner cavity of the connecting plate 416. The self-cleaning structure 4 also includes a gripper 418, a cleaning roller 419 and a groove 420. The gripper 418 is located on one side of the working block 417. The cleaning roller 419 is movably engaged in the inner cavity of the gripper 418. A groove 420 is opened on one side of the cleaning roller 419. The groove 420 and the locking post 421 are completely engaged.

[0028] Activating the pneumatic cylinder 47 causes the pneumatic rod 48 to extend and retract, thereby extending the fixed sleeve 411. At this time, one end of the connecting sleeve 412 is squeezed, while the other end moves the folding door 414 to both sides. The cleaning roller 419 is pushed out by the push block 49 and the upright rod 415. After being pushed out, the locking post 421 is inserted into the groove 420. At this time, the working block 417 is activated to release the clamping of the cleaning roller 419. Then, the first servo motor 22 drives the first motor shaft 23 to rotate, thereby rotating the rotating sleeve 41 and the rotating gear 43. Through the meshing transmission between the rotating gear 43 and the inner ring gear 44, the rotating gear 43 causes the cleaning roller 419 to rotate, thereby achieving the effect of automatic cleaning of the inside of the mixing tank 1.

[0029] The technical solution provided by this invention firstly involves the first servo motor 22 rotating the first motor shaft 23 and the multi-size gear set 24 when it starts. Through the meshing transmission between the multi-size gear set 24 and the small gear 312, the small gear 312 rotates the bottom small shear wheel 311 and the auxiliary shear wheel 314 to stir the material. At this time, the telescopic cylinder 34 is activated, lowering the lifting plate 36 and the hollow sleeve frame 38, thus lowering the small gear 312. This ensures that the small gear 312 is level with the gears below the multi-size gear set 24. Then, the second servo motor 325 is activated, causing the second motor shaft 324 and the rotating disk 323 to rotate, thereby moving the second connecting column 321 inside the arc-shaped groove 322. Meanwhile, due to the translation block 3... 20 is confined by the hollow groove 318, so that when the second connecting column 321 moves from the far end of the arc-shaped groove 322 to its inner end, the translation block 320, carrying the top second receiving plate 315 and the small gear 312, translates inward. This allows the small gear 312 to mesh with the gear set below the multi-size gear set 24, enabling the small gear 312 to perform multi-speed adjustment with the bottom small shear wheel 311 and auxiliary shear wheel 314. This allows for strong mixing at the highest speed during the mabalosavirin nucleation stage, rapidly and uniformly dispersing the seed crystals and inducing nucleation. During the crystal growth stage, the speed is reduced to weaken the shear force, protect the stable growth of the crystal, and reduce secondary nucleation. During the aging or ripening stage, the speed is adjusted to the lowest setting for gentle stirring to promote the growth of Oersted crystals. Wald ripening improves particle size distribution, thus meeting the multi-stage stirring requirements of the crystallization process during stirring. Then, when it is necessary to clean the inside of the stirring tank 1, the pneumatic cylinder 47 is activated to extend and retract the pneumatic rod 48, thereby extending the fixed sleeve 411. At this time, one end of the connecting sleeve 412 is squeezed, while the other end moves the folding door 414 to both sides. At this time, the cleaning roller 419 is pushed out by the push block 49 and the upright rod 415. After being pushed out, the locking post 421 is inserted into the groove 420. At this time, the working block 417 is activated to release the clamping of the cleaning roller 419. Then, the first servo motor 22 drives the first motor shaft 23 to rotate, thereby rotating the rotating sleeve 41 and the rotating gear 43. Through the rotation of the rotating gear 43 and the inner ring gear 44, The meshing transmission causes the rotating gear 43 to rotate, carrying the cleaning roller 419, thereby achieving automatic cleaning of the inside of the mixing tank 1. After cleaning, the rotating sleeve 41 rotates the rotating gear 43 to its initial position, and then the working block 417 extends to clamp and pull out the cleaning roller 419. The folding door 414 automatically closes, thus achieving automatic cleaning of the inside of the mixing tank 1. Furthermore, the cleaning components are completely isolated from the internal working device of the mixing tank 1 and are not affected by it. Finally, through the combined design of the main stirring structure 2 and the speed adjustment structure 3, multiple large-sized main shearing wheels 25 act as the main agitator to prevent local over- or under-saturation of the tank, while multiple small-sized mini shearing wheels 311 are set below the feed hopper 5.At high speeds, it can rapidly disperse the seed crystals or antisolvents added during processing, ensuring uniform nucleation or breaking up excessively large crystal clusters. Through the synergy of these two structures, and provided thorough mixing, it avoids problems such as insufficient mixing by a single stirrer leading to uneven nucleation or growth, or excessive shear causing crystal breakage or excessive secondary nucleation. It ensures rapid and uniform dispersion of the seed crystals during feeding, and provides controllable stirring and shearing during specific crystallization stages when the antisolvent is added, promoting uniform precipitation. Finally, through the movement of the above-mentioned device, it is possible to ensure rapid dispersion of seed crystals during feeding, provide controllable stirring and shearing, and meet the multi-stage stirring requirements of the crystallization process by adjusting the stirring speed. It can also achieve automatic cleaning, increasing its automation.

[0030] This invention encompasses any substitutions, modifications, equivalent methods, and solutions made within the spirit and scope of this invention. To provide the public with a thorough understanding of this invention, specific details are described in detail in the following preferred embodiments; however, those skilled in the art will fully understand the invention even without these details. Furthermore, to avoid unnecessary misunderstanding of the essence of this invention, well-known methods, processes, procedures, components, and circuits are not described in detail.

[0031] Those skilled in the art will understand that all or part of the steps in the methods of the above embodiments can be implemented by a program instructing related hardware. The program can be stored in a computer-readable storage medium, such as ROM / RAM, magnetic disk, optical disk, etc.

[0032] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A complex stirred crystallization apparatus for maraviroc production, characterized by, Including stirring tank (1), the inside of stirring tank (1) is provided with main stirring structure (2), the outside of main stirring structure (2) is provided with rotating speed adjusting structure (3), both sides of stirring tank (1) are provided with self-cleaning structure (4); The rotating speed adjusting structure (3) includes a bearing block (31), a receiving sleeve plate (32), a clamping plate (33), a telescopic cylinder (34), a telescopic rod (35), a lifting plate (36), a first receiving disc (317) and a base (328), the base (328) is fixedly installed at the bottom of the stirring tank (1), the first receiving disc (317) is fixedly installed at the top of the base (328), the bearing block (31) is fixedly installed at the top of the first receiving disc (317), the receiving sleeve plate (32) is fixedly installed at the top of the bearing block (31), the clamping plate (33) is fixedly installed in the receiving sleeve plate (32), the telescopic cylinder (34) is fixedly installed at the top of the clamping plate (33), the telescopic rod (35) is movably sleeved at the top of the telescopic cylinder (34), and the lifting plate (36) is fixedly installed at the top of the telescopic rod (35). The rotating speed adjusting structure (3) further includes a first connecting column (37), a hollow sleeve frame (38), a pulley (39), a hexagonal rotating rod (310), a small shear wheel (311), a small gear (312), a rotating sleeve (313) and an auxiliary shear wheel (314), the first connecting column (37) is fixedly installed at the top of both sides of the lifting plate (36), the first connecting column (37) is fixedly installed at the top of the first connecting column (37), the hollow sleeve frame (38) is movably sleeved on the surface of the first connecting column (37), the pulley (39) is fixedly installed on the upper and lower sides of the hexagonal rotating rod (310), the small shear wheel (311) is fixedly sleeved on the outer surface of the hexagonal rotating rod (310), the small gear (312) is fixedly sleeved on the top of the outer surface of the hexagonal rotating rod (310), the rotating sleeve (313) is fixedly installed at the bottom of the hexagonal rotating rod (310), and the auxiliary shear wheel (314) is fixedly sleeved on the outer surface of the rotating sleeve (313).

2. The compound stirring crystallization device for maraviroc production according to claim 1, characterized in that, The main stirring structure (2) includes a first motor support seat (21), a first servo motor (22) and a first motor shaft (23), the first motor support seat (21) is fixedly sleeved with the first servo motor (22) in the inner cavity, and the output shaft of the first servo motor (22) is fixedly sleeved with the first motor shaft (23) at one end.

3. The compound stirring crystallization device for maraviroc production according to claim 1, characterized in that, The main stirring structure (2) further includes a multi-size gear set (24), a main shear wheel (25) and a bottom disc (26), the multi-size gear set (24) is fixedly sleeved above the outer surface of the first motor shaft (23), a plurality of main shear wheels (25) are fixedly sleeved below the outer surface of the first motor shaft (23), and the bottom disc (26) is fixedly installed at the bottom end of the first motor shaft (23).

4. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The rotating speed adjusting structure (3) further comprises a second receiving disc (315), a receiving column (316), a hollow groove (318), a clamping plate (319) and a translation block (320), the second receiving disc (315) is movably sleeved at the bottom of the rotating sleeve (313), the bottom of the second receiving disc (315) is fixedly installed with the receiving column (316), the bottom of the receiving column (316) is fixedly installed with the translation block (320), the two sides of the translation block (320) are fixedly installed with the clamping plate (319), the clamping plate (319) is movably clamped in the hollow groove (318), and the hollow groove (318) is formed in the outer surface of the first receiving disc (317).

5. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The rotating speed adjusting structure (3) further comprises a second connecting column (321), an arc-shaped groove (322), a rotating disc (323), a second motor shaft (324), a second servo motor (325), a second motor support seat (326) and a bearing column (327), the second connecting column (321) is fixedly installed at the bottom of the translation block (320), the second connecting column (321) is movably clamped in the arc-shaped groove (322), the arc-shaped groove (322) is formed in the surface of the rotating disc (323), the inner cavity of the rotating disc (323) is fixedly sleeved with the second motor shaft (324), the second motor shaft (324) is fixedly installed at one end of the output shaft of the second servo motor (325), the outer surface of the second servo motor (325) is fixedly sleeved with the second motor support seat (326), and the bearing column (327) is fixedly installed at the bottom of the first receiving disc (317).

6. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The self-cleaning structure (4) comprises a rotating sleeve rod (41), a fixed column (42), a rotating gear (43), an inner ring gear (44), a connecting rod (46), a clamping column (421) and a working box (422), the rotating sleeve rod (41) is fixedly sleeved on one side of the outer surface of the first motor shaft (23), the two sides of the rotating sleeve rod (41) are movably sleeved with the fixed column (42), the outer surface of the fixed column (42) is fixedly sleeved with the rotating gear (43) at the bottom, the outer side of the rotating gear (43) is movably installed with the inner ring gear (44), the inner ring gear (44) is fixedly installed above the inside of the stirring tank (1), one side of the bottom of the rotating gear (43) is fixedly installed with the connecting rod (46), one side of the connecting rod (46) is fixedly installed with the clamping column (421), and the working box (422) is fixedly installed on the two sides of the stirring tank (1).

7. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The self-cleaning structure (4) further includes an air pressure cylinder (47), an air pressure rod (48), a push block (49), a guide rail (410), a fixed sleeve block (411), a connecting sleeve rod (412), a translation sleeve block (413) and a folding door (414), one end of the air pressure cylinder (47) is movably sleeved with the air pressure rod (48), one end of the air pressure rod (48) is fixedly installed with the push block (49), the surface of the push block (49) is fixedly installed with the fixed sleeve block (411) on both sides, the outer surface of the fixed sleeve block (411) is movably sleeved with the connecting sleeve rod (412), one side of the connecting sleeve rod (412) is movably sleeved with the translation sleeve block (413), one side of the translation sleeve block (413) is fixedly installed with the folding door (414).

8. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The self-cleaning structure (4) further includes a stand rod (415), a connecting plate (416), a working block (417), a clamping hand (418), a cleaning roller (419) and a embedded groove (420), the stand rod (415) is fixedly installed on both sides of the top of the push block (49), one side of the top of the stand rod (415) is fixedly installed with the connecting plate (416), the inner cavity of the connecting plate (416) is fixedly clamped with the working block (417).

9. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, The self-cleaning structure (4) further includes a clamping hand (418), a cleaning roller (419) and an embedded groove (420), the clamping hand (418) is arranged on one side of the working block (417), the inner cavity of the clamping hand (418) is movably clamped with the cleaning roller (419), one side of the cleaning roller (419) is provided with the embedded groove (420), and the embedded groove (420) and the clamping column (421) are completely embedded.

10. The compound stirring and crystallization device for maraviroc production according to claim 1, characterized in that, One side of the top of the stirring tank (1) is fixedly installed with the feeding hopper (5), and one side of the bottom of the outer surface of the stirring tank (1) is communicated with the discharging pipe (6).

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