Skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition as well as preparation and application thereof

Abstract

The invention belongs to the technical field of polymer functional materials, and particularly relates to a skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition as well as preparation and application thereof. The hydrogel composition is composed of N-isopropylacrylamide, an enhanced network component, a self-adhesion functional monomer, an anti-wear functional monomer, a water retention and ventilation component, a cross-linking agent, an initiator and a solvent. The hydrogel composition is in a liquid state or a semi-solidified state with the viscosity of 500 to 50000 mPa.s. The hydrogel composition disclosed by the invention is applied to the surface of skin in an extrusion or spraying manner, and is subjected to in-situ curing reaction under the light / heat triggering condition of body temperature and / or illumination to form a compact and flexible hydrogel film. The anti-abrasion pad can be used as a running chest pad, a leg pad, a palm pad, a sole pad, a heelpiece anti-abrasion pad and a movement protection pad at a joint part. The technical problems that an existing hydrogel product is poor in fitting performance, insufficient in abrasion resistance, inconvenient to peel and the like in the using process are effectively solved.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of high polymer functional materials, and particularly relates to a skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition and preparation and application thereof. BACKGROUND

[0002] In recent years, hydrogels are widely used in sports protection, wound care and skin adhesive products due to their good softness, biocompatibility and certain moisturizing effect. They can simulate the soft touch of the skin, maintain a moist microenvironment, and to some extent, disperse external force impact, becoming an important development direction of flexible adhesive materials. However, the existing commercially available sports patches, adhesive bandages and care hydrogels still have many technical bottlenecks. First, their adhesion is limited. During intense exercise or high-frequency joint activity, traditional hydrogel patches often have edge lifting, wrinkling or even peeling due to sweat infiltration, skin stretching and external friction, making it difficult to achieve long-term stable adhesion. Second, conventional hydrogels mainly have weak physical cross-linking or single network structure, and the internal network is soft but easily damaged by friction, so it is easily worn or peeled off in a repeated friction environment such as clothing and shoes, resulting in short service life and low use efficiency. Third, the application mode is limited. Most of the current hydrogels are supplied in the form of solid patches or dressings, and lack flexible use modes such as injection, spot coating or spray coating, making it difficult to achieve rapid in-situ gelation. Such fixed forms not only affect the convenience of carrying, but also limit their adaptability on irregular skin surfaces or joint parts. In addition, some hydrogels may cause skin stretching, irritation or slight damage when peeled off, affecting the user experience. The existing technology still lacks a hydrogel system that can combine skin-friendliness, wear resistance, self-adhesion and reversible peelability, and can be quickly cured into a film in-situ through extrusion or spray. Therefore, it has become an urgent technical problem to develop a hydrogel material that can be coated or sprayed into a film, quickly gel in a short time, and has wear resistance, long-term self-adhesion and peelability, which has important significance for sports protection and daily care applications. SUMMARY

[0003] In view of the shortcomings and deficiencies of the prior art, the primary purpose of the present application is to provide a skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition.

[0004] Another purpose of the present application is to provide a preparation method of the skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition.

[0005] Still another purpose of the present application is to provide the application of the skin-friendly wear-resistant self-adhesive in-situ curing hydrogel composition in sports protection and daily skin care.

[0006] The purpose of the present application is achieved by the following technical solutions: A kind of skin-friendly wear-resistant self-adhesion in situ solidification hydrogel composition, by N-isopropyl acrylamide (NIPAm), reinforcing network component, self-adhesion functional monomer, anti-wear functional monomer, water-retention and air-permeable component, crosslinking agent, initiator and solvent composition;The hydrogel composition is liquid or semi-solid form with viscosity of 500~50000 mPa·s.

[0007] Further, the reinforcing network component is selected from at least one of nanocellulose (CNF), xanthan gum, aloe vera whole leaf dry powder, gelatin (Gel), sodium alginate (SA).

[0008] Further, the self-adhesion functional monomer is selected from at least one of dopamine methacrylamide (DMA), 2-aminoethyl methacrylate (AEMA), hydroxyethyl methacrylate (HEMA).

[0009] Further, the anti-wear functional monomer is selected from at least one of 2-methacryloyloxyethyl phosphorylcholine (MPC), sulfobetaine methacrylate (SBMA), carboxybetaine methacrylate (CBMA), polyethylene glycol methacrylate (PEGMA, number average molecular weight ≥ 300).

[0010] Preferably, the anti-wear functional monomer is a combination of any one of MPC, SBMA, CBMA and PEGMA. By balancing the charge of any one of the zwitterionic monomers MPC, SBMA, CBMA to reduce the electrostatic adsorption force of the solidified gel film, combined with the lubricating effect of PEGMA, the anti-wear performance of the solidified gel film can be further synergistically improved.

[0011] Further, the water-retention and air-permeable component is selected from at least one of glycerol, polyethylene glycol (PEG), porous SiO2.

[0012] Further, the crosslinking agent is selected from at least one of N,N'-methylenebisacrylamide (BIS) and genipin.

[0013] Preferably, the reinforcing network component uses a combination of nanocellulose (CNF) and gelatin (Gel); the crosslinking agent uses a combination of N,N'-methylenebisacrylamide (BIS) and genipin.

[0014] Under the above combination of reinforcing network component and combination of crosslinking agent, a composite reinforcing structure of chemical crosslinking network and physical network can be formed, thereby significantly improving the comprehensive performance of the gel film.

[0015] Further, the initiator is one of riboflavin / arginine, riboflavin / triethanolamine, Eosin Y / tertiary amine, LAP visible light initiation system.

[0016] Further, the solvent is water.

[0017] Further, the mass percentage composition of the hydrogel composition is as follows: NIPAm: 20-70 wt%, reinforcing network component: 5-40 wt%, self-adhesion functional monomer: 1-15 wt%, anti-wear functional monomer: 1-15 wt%, water-retention and air-permeation component: 5-30 wt%, crosslinking agent: 0.05-2 wt%, initiator: 0.05-0.5 wt%, and the balance is solvent.

[0018] More preferably, the mass percentage composition of the hydrogel composition is as follows: NIPAm: 30-45 wt%, reinforcing network component: 5-20 wt%, self-adhesion functional monomer: 3-8 wt%, anti-wear functional monomer: 3-8 wt%, water-retention and air-permeation component: 15-30 wt%, crosslinking agent: 0.1-1 wt%, initiator: 0.05-0.25 wt%, and the balance is solvent.

[0019] The preparation method of the above-mentioned skin-friendly, wear-resistant, self-adhesive, in-situ solidified hydrogel composition comprises the following preparation steps: NIPAm, reinforcing network component, self-adhesion functional monomer, anti-wear monomer, water-retention and air-permeation component, crosslinking agent, and initiator are sequentially added to the solvent for stirring, mixing, dissolving, and dispersing until the system is uniform and transparent, and then the system is sealed and stored in a light-tight syringe or spray bottle to obtain the skin-friendly, wear-resistant, self-adhesive, in-situ solidified hydrogel composition.

[0020] The above-mentioned skin-friendly, wear-resistant, self-adhesive, in-situ solidified hydrogel composition is applied in sports protective products and daily skin care products.

[0021] Further, the sports protective products and daily skin care products include, but are not limited to, running chest patches, leg patches, palm patches, sole patches, shoe heel anti-wear patches, and sports protective patches for joint parts such as knees and elbows.

[0022] Further, the application method is to apply the hydrogel composition to the skin surface by extrusion coating or spray coating, and the in-situ solidification reaction occurs under the triggering conditions of body temperature (about 32-37℃) and / or light / heat, to form a dense and flexible hydrogel film.

[0023] The hydrogel composition of the present application is based on the dual-response mechanism of combining temperature-sensitive response with light-triggered solidification: The adopted main monomer N-isopropyl acrylamide (NIPAm) has a clear lower critical solution temperature (LCST, about 32℃), and the system can rapidly undergo phase separation and gel transition from sol state when the temperature approaches human body temperature. Meanwhile, in combination with visible light initiation system (such as riboflavin / arginine, riboflavin / triethanolamine, Eosin Y / tertiary amine, LAP, etc.), rapid crosslinking and curing can be further achieved under natural light or outdoor light conditions. Through the cooperation with the enhanced network components (such as CNF, xanthan gum, full leaf dry powder of aloe vera, Gel, SA, etc.), the system forms a chemical-physical double network structure, which significantly improves the tensile, wear resistance and deformation recovery ability of the hydrogel. Through the zwitterionic properties of the anti-wear functional monomers (such as MPC, SBMA, CBMA), the balance of electric charge reduces the electrostatic adsorption and / or the introduction of molecular chains with lubricating properties (such as PEGMA) can reduce the adhesion force of the cured gel film to external contact objects, thereby improving the wear resistance. Further introduction of self-adhesion functional monomers (such as DMA, AEMA, HEMA, etc.) can endow the uncured hydrogel with the ability to form multiple-point hydrogen bonds and polar adsorption on the skin surface, thereby achieving rapid adhesion, stable adhesion and reversible peeling. In addition, through the synergistic effect of water-retaining and air-permeable components (such as glycerol, PEG, porous SiO2, etc.), high water content and microporous channels can be maintained to achieve long-lasting moisturizing and air-permeable comfort for the skin.

[0024] Compared with the prior art, the present application has the following advantages: (1) The hydrogel composition of the present application has the characteristics of skin-friendly, wear-resistant, self-adhesive, air-permeable and moisturizing, and has the characteristics of rapid in-situ curing, which can achieve rapid gelation and stable adhesion on the skin surface, and can maintain stable adhesion and structural integrity in the environment of movement or long-term sun exposure. The technical problems of poor adhesion, insufficient wear resistance and difficulty in balancing self-adhesion and reversible peeling of existing hydrogel products during use are solved.

[0025] (2) The present application introduces self-adhesion functional monomers and multifunctional crosslinking network and light / heat sensitive components into the hydrogel system, so that the obtained material can achieve instant adhesion and self-adhesion when contacting the skin, and rapidly cure and form under the action of body temperature or environmental temperature, thereby significantly improving the convenience and comfort of use.

[0026] (3) The hydrogel composition of the present application is in the form of liquid or semi-solid with a viscosity of 500-50000 mPa·s, which can be stored in a syringe or a spray bottle after being sealed and divided, and can be easily applied by extrusion, coating or spraying. The cured gel film has good mechanical strength, no residue after peeling, and is easy to peel off. DETAILED DESCRIPTION

[0027] The application will be further described in detail below with reference to examples, but the embodiments of the application are not limited thereto.

[0028] All monomers of the application are biomass raw materials, residual monomer is controlled <50 ppm, skin-friendly, non-toxic; the obtained product passes the cytotoxicity, skin irritation, and sensitization tests, and meets the ISO10993 standard; the obtained product has no animal-derived allergenic proteins, has a pH range of 6.0-7.0, and meets the requirements of a weak acid environment of the skin. Example 1

[0029] A skin-friendly and wear-resistant self-adhesion in-situ curing hydrogel composition (riboflavin / arginine light curing + MPC anti-wear type) is composed of the following ingredients with mass percentage (wt%): NIPAm 40%, xanthan gum 10%, glycerol 10%, PEG (Mn≈400) 10%, MPC 4%, DMA 4%, nanocellulose 2%, BIS 0.3%, riboflavin 0.05%, arginine 0.15%, and the rest is deionized water.

[0030] The preparation method of the hydrogel composition is as follows: NIPAm, xanthan gum, glycerol, PEG, MPC, DMA, nanocellulose, BIS, riboflavin, and arginine are weighed according to the above mass percentage ratio, added to deionized water, magnetically stirred to dissolve and disperse to be clear, vacuum degassing, and then divided into black syringes to obtain a skin-friendly and wear-resistant self-adhesion in-situ curing hydrogel composition with a viscosity of 16500 mPa·s.

[0031] Application of the above-mentioned skin-friendly and wear-resistant self-adhesion in-situ curing hydrogel composition in sports protective products and daily skin care products: When used, the hydrogel composition is extrusion coated on the target area of the skin, irradiated with 450-520 nm visible light (LED handheld light source or natural sunlight direct) for 20-40 s, and rapidly in-situ gelled and cured into a film under the joint action of body temperature.

[0032] The cured gel film obtained in this example has a friction coefficient of 0.1516±0.0251, a wear of 4.62wt% under a pressure of 0.5N for 1000 times of reciprocating friction, a tensile strength of 232kPa, a breaking elongation of 2120%, a peeling strength of 35kPa, no peeling after 1800 times of repeated bending, and no residue after peeling.

[0033] Comparative Example 1 Compared with Example 1, Comparative Example 1 does not add anti-wear functional monomer MPC, and the rest is the same.

[0034] The cured gel film obtained in the present comparative example has a friction coefficient of 0.2335 ± 0.0314, an abrasion of 12.18 wt% under 1000 reciprocating rubs at a pressure of 0.5 N, a tensile strength of 215 kPa, an elongation at break of 1925%, a peeling strength of 35 kPa, no peeling after 1800 repeated bendings, and no residue after peeling.

[0035] It can be concluded from the comparison with Example 1 that the present application can significantly reduce the friction coefficient and abrasion of the cured gel film by adding the anti-wear monomer.

[0036] Comparative Example 2 The present comparative example is the same as Example 1 except that the self-adhesion functional monomer DMA is not added.

[0037] The cured gel film obtained in the present comparative example has a friction coefficient of 0.1485 ± 0.0235, an abrasion of 4.60 wt% under 1000 reciprocating rubs at a pressure of 0.5 N, a tensile strength of 207 kPa, an elongation at break of 2280%, a peeling strength of 19 kPa, and peeling after 1000 repeated bendings.

[0038] It can be concluded from the comparison with Example 1 that the present application can significantly improve the adhesion stability of the cured gel film by adding the self-adhesion functional monomer. Example 2

[0039] The present example is the same as Example 1 except that 2% MPC + 2% PEGMA (number average molecular weight 500) are used as the anti-wear functional monomer.

[0040] The cured gel film obtained in the present example has a friction coefficient of 0.1325 ± 0.0184, an abrasion of 2.76 wt% under 1000 reciprocating rubs at a pressure of 0.5 N, a tensile strength of 210 kPa, an elongation at break of 2290%, a peeling strength of 32 kPa, no peeling after 1800 repeated bendings, and no residue after peeling.

[0041] It can be concluded from the comparison with Example 1 that the present application can synergistically improve the wear resistance of the cured gel film by using the zwitterionic functional monomer with charge balance effect in combination with the functional monomer with lubricating effect. Example 3

[0042] A skin-friendly wear-resistant self-adhesion in-situ cured hydrogel composition (Eosin Y / tertiary amine photocuring + SBMA / PEGMA synergistic wear resistance) is composed of the following ingredients with mass percentage (wt%): NIPAm 35%, xanthan gum 10%, aloe vera whole leaf dry powder 8%, SBMA 5%, PEGMA (number average molecular weight 500) 3%, AEMA 4%, PEG 8%, glycerol 12%, mesoporous SiO2 1%, BIS 0.2%, Eosin Y 0.02%, triethanolamine (TEA) 0.2%, and the rest is deionized water.

[0043] The preparation method of the hydrogel composition is as follows: NIPAm, xanthan gum, aloe vera whole leaf dry powder, SBMA, PEGMA, AEMA, PEG, glycerol, mesoporous SiO2, BIS, Eosin Y and TEA are weighed according to the above mass percentage ratio, added to deionized water, magnetically stirred to dissolve and disperse to be clear, vacuum degassing, and then divided into black syringes to obtain a skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition with a viscosity of 20800 mPa·s.

[0044] The above-mentioned skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition is applied in sports protective products and daily skin care products: When used, the hydrogel composition is extruded on the target area of the skin, and irradiated with 520-540 nm green light for 20-40 s to cure into a film. The zwitterionic monomer SBMA and the lubricating monomer PEGMA synergistically provide low abrasion and anti-staining performance, and still maintain adhesion and structural integrity under sweating and repeated rubbing.

[0045] The cured gel film obtained in this example has a friction coefficient of 0.1270±0.0212, an abrasion of 2.81wt% under 0.5N pressure for 1000 times of reciprocating friction, a tensile strength of 266kPa, an elongation at break of 1675%, a peel strength of 40kPa, and no peeling and residue after 1800 times of repeated bending. Example 4

[0046] A skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition (LAP light curing + SA / CNF physical-chemical double network enhancement) is composed of the following mass percentage (wt%) of ingredients: NIPAm 38%, SA 5%, xanthan gum 7%, CNF 1.5%, CBMA 4%, DMA 3%, PEG 10%, glycerol 10%, BIS 0.25%, LAP 0.1%, and the rest is deionized water.

[0047] The preparation method of the hydrogel composition is as follows: NIPAm, SA, xanthan gum, CNF, CBMA, DMA, PEG, glycerol, BIS and LAP were weighed according to the above mass percentage ratio, added to deionized water, magnetically stirred to dissolve and disperse to clarity, vacuum degassing, and then divided into light-tight compression bottles to obtain a skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition with a viscosity of 25700 mPa·s.

[0048] Application of the above-mentioned skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition in sports protective products and daily skin care products: When in use, the hydrogel composition is extruded on the joint parts such as knees / elbows, and irradiated with 405 nm blue-violet light for 10-30 s for rapid curing; SA and CNF provide an ion-hydrogen bond synergistic physical network, which forms a double network with excellent toughness in cooperation with chemical crosslinking.

[0049] The cured gel film obtained in this example has a friction coefficient of 0.1564±0.0243, a wear of 3.87wt% under a pressure of 0.5N for 1000 times of reciprocating friction, a tensile strength of 306kPa, an elongation at break of 2010%, and a peeling strength of 43kPa; no peeling and no residue after 1800 times of repeated bending. Example 5

[0050] A skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition (Riboflavin / Arginine photo-curing + Gel composite with Genipin post-curing enhancement), which is composed of the following mass percentage (wt%) ingredients: NIPAm 45%, Gel 8%, CNF 6%, DMA 3%, MPC 3%, PEG 10%, glycerol 12%, BIS 0.2%, Genipin 0.2%, Riboflavin 0.03%, Arginine 0.1%, and the rest is deionized water.

[0051] The preparation method of the hydrogel composition is as follows: NIPAm, Gel, CNF, DMA, MPC, PEG, glycerol, BIS, Genipin, Riboflavin and Arginine were weighed according to the above mass percentage ratio, added to deionized water, magnetically stirred to dissolve and disperse to clarity, vacuum degassing, and then divided into black syringes to obtain a skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition with a viscosity of 9600 mPa·s.

[0052] Application of the above-mentioned skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition in sports protective products and daily skin care products: The hydrogel composition is extruded on the skin to form a film and irradiated with 450-520 nm light for 20-40 s to obtain instant curing and adhesion; then the Genipin and Gel amino slowly react at body temperature to achieve secondary chemical crosslinking, significantly improving wear resistance and fatigue resistance without affecting reversible peelability, suitable for long-term sports protection.

[0053] The cured gel film obtained in this example was tested for friction coefficient of 0.1642±0.0280, wear of 2.85wt% under 0.5N pressure for 1000 times of reciprocating friction; tensile strength of 468kPa, elongation at break of 1600%; peel strength of 38kPa; no shedding after 1800 times of repeated bending, no residue after peeling. Example 6

[0054] In this example, compared with Example 5, no reinforcing network component Gel and crosslinking agent Genipin are added, and the CNF content is increased to 14%, and the rest is the same.

[0055] The cured gel film obtained in this example was tested for friction coefficient of 0.1650±0.0176, wear of 4.50wt% under 0.5N pressure for 1000 times of reciprocating friction; tensile strength of 270kPa, elongation at break of 2065%; peel strength of 39kPa; no shedding after 1800 times of repeated bending, no residue after peeling.

[0056] From the comparison results of Example 5, it can be concluded that the use of gelatin (Gel) and genipin (Genipin) composite crosslinking reinforcing network in the present application can synergistically improve the wear resistance and strength performance of the cured gel film. Example 7

[0057] A skin-friendly, wear-resistant, self-adhesive in-situ curing hydrogel composition (highly breathable and light and thin: Eosin Y light curing spray + SiO2 breathable and moisture permeable), consisting of the following mass percentage (wt%) of ingredients: NIPAm 30%, Gel 5%, CNF 0.5%, SBMA 4%, AEMA 3%, PEG 15%, glycerol 15%, mesoporous SiO2 2%, BIS 0.15%, Eosin Y 0.015%, TEA 0.15%, and the rest is deionized water.

[0058] The preparation method of the hydrogel composition is as follows: NIPAm, Gel, CNF, SBMA, AEMA, PEG, glycerol, mesoporous SiO2, BIS, Eosin Y and TEA were weighed according to the above mass percentage ratio, added into deionized water, ultrasonically dispersed for 5 min, defoamed, and then loaded into a light-tight pressure spray bottle (0.3-0.5 mm nozzle) to obtain a skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition with a viscosity of 850 mPa·s.

[0059] Application of the above-mentioned skin-friendly and wear-resistant self-adhesive in-situ curing hydrogel composition in sports protective products and daily skin care products: When in use, the hydrogel composition is uniformly sprayed on the heel or the friction hot spot in the shoe, and a film is formed under the irradiation of outdoor sunlight or 525 nm LED for 20-40 s; the film thickness is 500-1000 µm, the MVTR is high, the stuffiness is low, the long-acting moisturizing is good, and the wear resistance is good.

[0060] The cured gel film obtained in the example is tested for sample preparation, and the friction coefficient is 0.1469±0.0227, the wear under the pressure of 0.5 N for 1000 times of reciprocating friction is 4.06wt%, the water vapor transmission rate is 12.6g / m² / 24h, the tensile strength is 247kPa, the elongation at break is 1975%, the peeling strength is 36kPa, and there is no peeling and no residue after 1800 times of repeated bending.

[0061] The above-mentioned embodiments are the preferred embodiments of the present application, but the embodiments of the present application are not limited to the above-mentioned embodiments, and any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present application should be equivalent replacement methods, and all are included in the protection scope of the present application.

Claims

1. A skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition, characterized in that: The hydrogel composition is composed of N-isopropylacrylamide, reinforcing network components, self-adhesive functional monomers, abrasion-resistant functional monomers, water-retaining and breathable components, crosslinking agents, initiators, and solvents; the hydrogel composition is in liquid or semi-solid form with a viscosity of 500~50000 mPa·s.

2. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 1, characterized in that: The reinforcing network component is selected from at least one of nanocellulose, xanthan gum, whole leaf powder of Aloe vera, gelatin, and sodium alginate; the self-adhesive functional monomer is selected from at least one of dopamine methacrylamide, 2-aminoethyl methacrylate, and hydroxyethyl methacrylate; the anti-wear functional monomer is selected from at least one of 2-methacryloyloxyethyl phosphorylcholine, sulfobetaine methacrylate, carboxybetaine methacrylate, and polyethylene glycol methacrylate; and the water-retaining and breathable component is selected from at least one of glycerin, polyethylene glycol, and porous SiO2.

3. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 1, characterized in that: The anti-wear functional monomer is a combination of any one of 2-methacryloyloxyethyl phosphorylcholine, sulfobetaine methacrylate, and carboxybetaine methacrylate with polyethylene glycol methacrylate.

4. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 1, characterized in that: The crosslinking agent is selected from at least one of N,N′-methylenebisacrylamide and genipin; the initiator is one of riboflavin / arginine, riboflavin / triethanolamine, Eosin Y / tertiary amine, and LAP visible light initiation system; the solvent is water.

5. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 1, characterized in that: The reinforcing network component is a combination of nanocellulose and gelatin; the crosslinking agent is a combination of N,N′-methylenebisacrylamide and genipin.

6. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 1, characterized in that: The hydrogel composition has the following mass percentage composition: N-Isopropylacrylamide: 20-70 wt%, Reinforcing network component: 5-40 wt%, Self-adhesive functional monomer: 1-15 wt%, Anti-abrasion functional monomer: 1-15 wt%, Water-retaining and breathable component: 5-30 wt%, Crosslinking agent: 0.05-2 wt%, Initiator: 0.05-0.5 wt%, Balance is solvent.

7. The skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to claim 6, characterized in that: The hydrogel composition has the following mass percentage composition: N-Isopropylacrylamide: 30-45 wt%, Reinforcing network component: 5-20 wt%, Self-adhesive functional monomer: 3-8 wt%, Anti-abrasion functional monomer: 3-8 wt%, Water-retaining and breathable component: 15-30 wt%, Crosslinking agent: 0.1-1 wt%, Initiator: 0.05-0.25 wt%, Balance: Solvent.

8. A method for preparing a skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to any one of claims 1 to 7, characterized in that... The preparation steps include the following: N-Isopropylacrylamide, reinforcing network components, self-adhesive functional monomers, abrasion-resistant monomers, water-retaining and breathable components, crosslinking agents, and initiators are sequentially added to a solvent and stirred, mixed, dissolved, and dispersed until the system is uniform and transparent. Then, it is sealed and stored in an opaque syringe or spray bottle to obtain a skin-friendly, abrasion-resistant, self-adhesive, in-situ curing hydrogel composition.

9. The application of the skin-friendly, wear-resistant, self-adhesive, in-situ curing hydrogel composition according to any one of claims 1 to 7 in sports protective equipment and daily skin care products, characterized in that: The sports protective equipment and daily skin care products mentioned are running chest patches, leg patches, palm patches, foot patches, shoe heel anti-friction patches, or sports protective patches for the knee and elbow joints.

10. The application according to claim 9, characterized in that... The application method is as follows: the hydrogel composition is applied to the skin surface by extrusion or spraying, and an in-situ curing reaction occurs under the light / heat triggering conditions of body temperature and / or light, forming a dense and flexible hydrogel film.