Composition as well as preparation method and related application thereof

Abstract

The invention discloses a composition and a preparation method and related application thereof, and relates to the field of cosmetics, ergothioneine and adsorptive soil are compounded, the pH value of a system is adjusted to be weak acid, the defects that ergothioneine is sensitive to light, prone to degradation at high temperature and the like are overcome, the composition does not generate peculiar smell under the conditions of light and high temperature, and the composition is environmentally friendly. The ergothioneine is suitable for processing of dosage forms such as cosmetics, and the application bottleneck of ergothioneine industrialization is effectively broken through.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and more specifically, to a composition, its preparation method, and related applications. Background Technology

[0002] Ergothioneine, a natural sulfur-containing amino acid antioxidant discovered in 1909, has broad application potential in cosmetics, pharmaceuticals, and food due to its excellent free radical scavenging, anti-inflammatory, and cell protection functions: in cosmetics, it can reduce reactive oxygen species and protect against radiation, and is used in outdoor and protective products; in the pharmaceutical field, it can help protect transplanted organs and advance ophthalmic surgery; in the food field, it can maintain quality and extend shelf life through antioxidation.

[0003] However, while the thiol group (-SH) in its molecule imparts high activity, it also makes it sensitive to light, high temperature, and extreme pH: In cosmetic formulations, light exposure for two weeks reduces retention to 60%-70% and produces an unpleasant odor; under alkaline conditions, it generates tetramethylamine hydroxide (which decomposes into trimethylamine upon heating), and high heat or ultraviolet light can also trigger the decomposition / photoreaction of the trimethylamine group, releasing a characteristic odor. Light exposure is the primary cause of this odor among the four conditions. This problem severely damages product stability and user experience, becoming a core bottleneck for its commercialization.

[0004] Currently, the industry is trying to alleviate the problem through compounding or process optimization. For example, compounding licorice extract with cyclodextrin can improve photostability and mask off-odors, but it has limited ability to inhibit the synergistic effect of high temperature and light. Off-odors may still occur after long-term storage, and a high quality ratio of 20:1 (licorice extract: ergothioneine) is required, which significantly increases costs.

[0005] In conclusion, developing efficient and economical methods to improve the stability of ergothioneine is urgently needed and is of great significance for fully realizing its functions and promoting its large-scale application in various fields.

[0006] In view of this, the present invention is proposed. Summary of the Invention

[0007] The purpose of this invention is to provide a composition, a method for preparing the composition, and related applications.

[0008] This invention is implemented as follows: In a first aspect, embodiments of the present invention provide a composition comprising: a buffer system, absorbent soil, ergothioneine, and water; wherein the absorbent soil has a mass-volume percentage of 0.01% to 5%, and the ergothioneine has a mass-volume percentage of 0.01% to 5%; and the composition has a pH of 4.5 to 6.5.

[0009] Secondly, embodiments of the present invention provide a method for preparing the composition as described in the foregoing embodiments, comprising: mixing the components in the composition.

[0010] Thirdly, embodiments of the present invention provide a cosmetic product comprising a cosmetic base and the composition described in the foregoing embodiments.

[0011] Fourthly, embodiments of the present invention provide the use of the compositions described in the foregoing embodiments in the preparation of products containing ergothioneine.

[0012] The present invention has the following beneficial effects: This invention addresses the shortcomings of ergothioneine, such as its sensitivity to light and easy degradation at high temperatures, by combining ergothioneine with absorbent soil and adjusting the pH of the system to a weakly acidic state. The composition of this invention produces no odor under light and high temperature conditions, making it suitable for processing into cosmetic and other dosage forms, effectively breaking through the application bottleneck of ergothioneine industrialization. Attached Figure Description

[0013] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 These are photos of some samples after illumination; among them, TMT is bentonite 2, SS is bentonite 3, K082 is kaolinite 1, and K041 is kaolinite 2. Figure 2 These are photos of some samples after the high and low temperature cycling test; among them, TMT is bentonite 2, SS is bentonite 3, K082 is kaolinite 1, and K041 is kaolinite 2. Figure 3 These are photos of some samples after being exposed to high temperature (45℃) for one month; among them, TMT is bentonite 2, SS is bentonite 3, K082 is kaolinite 1, and K041 is kaolinite 2. Detailed Implementation

[0015] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0016] On one hand, embodiments of the present invention provide a composition comprising: a buffer system, absorbent soil, ergothioneine, and water; wherein the absorbent soil has a mass-volume percentage of 0.01% to 5%, and the ergothioneine has a mass-volume percentage of 0.01% to 5%; and the composition has a pH of 4.5 to 6.5.

[0017] In some embodiments, the components in the composition are in an independent state or in a mixed state. When in a mixed state, the composition is a water-soluble formulation.

[0018] In some embodiments, the adsorbent soil includes any one or more of bentonite, kaolinite, montmorillonite, attapulgite, illite, diatomite, zeolite, and sepiolite.

[0019] In some embodiments, the mass-volume percentage of the adsorbent soil can be any one or a range between any two of the following: 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 2.2%, 2.4%, 2.6%, 2.8%, 3%, 3.2%, 3.4%, 3.6%, 3.8%, 4%, 4.2%, 4.4%, 4.6%, 4.8%, and 5%.

[0020] In some embodiments, the mass-volume percentage of ergothioneine can be any one or a range between any two of the following: 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 2.2%, 2.4%, 2.6%, 2.8%, 3%, 3.2%, 3.4%, 3.6%, 3.8%, 4%, 4.2%, 4.4%, 4.6%, 4.8%, and 5%.

[0021] In some embodiments, the pH of the composition may specifically be any one or a range between any two of the following: 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, and 6.5.

[0022] In some embodiments, the buffer system is selected from any one of: citric acid-sodium citrate, acetic acid-sodium acetate, lactic acid-sodium lactate, succinic acid-sodium succinate, potassium hydrogen phthalate-hydrogen phosphate, and sodium monohydrogen phosphate-sodium dihydrogen phosphate-sodium phosphate.

[0023] On the other hand, embodiments of the present invention provide a method for preparing a composition as described in any of the foregoing embodiments, which includes: mixing the components in the composition.

[0024] In some embodiments, the mixing step includes: The absorbent soil and some water were mixed to obtain mixture A; Mix the mixture A with ergothioneine to obtain mixture B; Obtain solution C by mixing the buffer system with a portion of water; The pH of the mixture B is adjusted to 4.5-6.5 using solution C. This pH is the same as that of the compositions described in any of the foregoing embodiments.

[0025] In some embodiments, the mixing ratio of the adsorbent soil and water is (0.2~0.5) g : (10~50) mL; the (0.2~0.5) g can specifically be any one or any two of 0.2, 0.3, 0.4 and 0.5 g, and the (10~50) mL can specifically be any one or any two of 10, 15, 20, 25, 30, 35, 40, 45 and 50 mL, and can be selected as (0.2~0.5) g : (30~40) mL.

[0026] On the other hand, embodiments of the present invention provide a cosmetic product comprising a cosmetic base and the composition described in any of the foregoing embodiments.

[0027] Furthermore, embodiments of the present invention also provide the use of the compositions described in any of the foregoing embodiments in the preparation of products containing ergothioneine.

[0028] In some embodiments, the efficacy of the product includes any one or more of the following: antioxidant, anti-inflammatory, and cell-protective properties; In some embodiments, the product includes cosmetics.

[0029] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0030] Example 1 Sixteen experimental groups were set up, each providing an aqueous solution composition, which included: a buffer system, adsorbent soil, ergothionein and water. The difference lay in the type or ratio of each component, and the specific proportions are shown in Table 1.

[0031] Table 1. Components and proportions of the composition

[0032] Note: The percentages for adsorbed soil and ergothioneine are both mass-volume percentages. Solution C of the buffer system in Group 1 consisted of 30.5 mL of 0.1 M citric acid solution and 34.75 mL of 0.2 M sodium citrate solution.

[0033] The composition is prepared as follows: Take the adsorbent soil, ergothionein, buffer system and water according to the proportions described in Table 1; The absorbent soil and a portion of water were mixed (in a ratio of 0.25 g: 34 mL) to obtain mixture A; Mix the mixture A with ergothioneine to obtain mixture B; mix the buffer system with a portion of water to obtain solution C containing the buffer system; adjust the pH of mixture B to a set value using solution C containing the buffer system.

[0034] The taste scores of the 16 samples after being exposed to light (6000 lux) for 2 weeks and at high temperature (45℃) for 1 month are shown in Table 1.

[0035] Table 1 Scoring Results

[0036] Scoring criteria: Direct smell: 5 points: almost no obvious characteristic odor; 4 points: almost no fishy smell; 3 points: slight fishy smell; 2 points: fishy smell; 1 point: obvious characteristic odor with a strong fishy smell. After application: 5 points: almost no obvious characteristic odor after application and semi-drying; 4 points: almost no fishy smell after application and semi-drying; 3 points: slight fishy smell after application and semi-drying; 2 points: fishy smell after application and semi-drying; 1 point: obvious characteristic odor with a strong fishy smell after application and semi-drying.

[0037] Photos of some samples after illumination are shown below. Figure 1 Photos of some samples after high and low temperature cycling tests are shown below. Figure 2 Photos of some samples taken after being heated to 45°C for one month are shown below. Figure 3 .

[0038] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A composition, characterized in that, It comprises: a buffer system, absorbent soil, ergothioneine, and water; the absorbent soil has a mass-volume percentage of 0.01% to 5%, and the ergothioneine has a mass-volume percentage of 0.01% to 5%; the pH of the composition is 4.5 to 6.

5.

2. The composition according to claim 1, characterized in that, The adsorbent soils include any one or more of the following: bentonite, kaolin, montmorillonite, attapulgite, illite, diatomite, zeolite, and sepiolite.

3. The composition according to claim 1, characterized in that, The mass-volume percentage of the adsorbent soil is 0.1% to 4%.

4. The composition according to claim 1, characterized in that, The mass-volume percentage of ergothioneine is 0.1% to 4%.

5. The composition according to claim 1, characterized in that, The pH of the composition is 5.0 to 6.

0.

6. The composition according to claim 1, characterized in that, The buffer system is selected from any one of the following: citric acid-sodium citrate, acetic acid-sodium acetate, lactic acid-sodium lactate, succinic acid-sodium succinate, potassium hydrogen phthalate-hydrogen phosphate, and sodium monohydrogen phosphate-sodium dihydrogen phosphate-sodium phosphate.

7. A method for preparing the composition according to any one of claims 1 to 6, characterized in that, It includes: Mix the components in the composition.

8. The preparation method according to claim 7, characterized in that, The mixing step includes: The absorbent soil and water are mixed to obtain mixture A; Mix the mixture A with ergothioneine to obtain mixture B; Obtain solution C obtained by mixing the buffer system with water; The pH of the mixture B was adjusted to 4.5-6.5 using solution C. Optionally, the mixing ratio of the adsorbent soil and water is (0.2~0.5) g: (10~50) mL.

9. A cosmetic product, characterized in that, It includes a cosmetic base and the composition according to any one of claims 1 to 6.

10. The use of the composition according to any one of claims 1 to 6 in the preparation of products containing ergothioneine; Optionally, the efficacy of the product includes any one or more of the following: antioxidant, anti-inflammatory, and cell-protective properties; Optionally, the product includes cosmetics.

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