Composite traditional Chinese medicine acne-removing mud cream and preparation method thereof

Abstract

The invention provides compound traditional Chinese medicine acne-removing cream and a preparation method thereof, and belongs to the technical field of cosmetics. The paste is prepared from the following components in percentage by mass: 10-25% of a filling matrix, 5-15% of a compound traditional Chinese medicine acne-removing component, 0.5-2% of a thickening agent, 5-15% of a humectant, 0.5-2% of a preservative and the balance of deionized water. The compound traditional Chinese medicine acne-removing component is prepared from burdock root extract, artemisia annua extract, salvia officinalis leaf extract and sophora flavescens extract through scientific compatibility. Through the synergistic effect of the compound traditional Chinese medicine acne-removing extract, the acne-removing cream disclosed by the invention has the effects of remarkably inhibiting propionibacterium acnes and resisting inflammation, and comprehensively realizes the effects of efficiently removing acnes, mildly relieving, and being safe and non-irritating in combination with the physical adsorption effect of the cream matrix.

Description

Technical Field

[0001] This invention belongs to the field of daily cosmetics technology, specifically relating to a compound acne-removing mud paste and its preparation method, and more particularly to an acne-removing mud paste containing burdock root extract, Artemisia annua extract, Salvia miltiorrhiza leaf extract and Sophora flavescens extract as compound active ingredients and its preparation method. Background Technology

[0002] Acne, commonly known as "pimples," is a common skin problem that primarily affects areas rich in sebaceous glands, such as the face, chest, and back. Its pathogenesis is complex, closely related to multiple factors including excessive sebum secretion, abnormal keratinization of the pilosebaceous duct, excessive proliferation of microorganisms such as Propionibacterium acnes, and the inflammatory response it triggers. Various types of products are available on the market for the treatment and care of acne. Currently, mainstream acne-fighting ingredients include retinoids, benzoyl peroxide, salicylic acid, azelaic acid, and antibiotics. However, these often have problems such as strong irritation, hormone dependence, and easy recurrence, and are frequently accompanied by significant side effects such as skin irritation, dermatitis, dryness, peeling, photosensitivity, and drug resistance, affecting adherence and long-term treatment effectiveness. Therefore, they are not suitable for long-term, gentle use as daily skincare ingredients.

[0003] Traditional Chinese medicine (TCM) has a long history and rich experience in treating skin sores and boils. Many Chinese herbs have been proven to have anti-inflammatory, antibacterial, antioxidant, and immunomodulatory effects, providing a valuable resource for developing gentle yet effective acne treatment products. In recent years, cosmetics containing TCM ingredients have gradually gained market favor. Natural plant extracts, due to their gentleness, safety, and diverse bioactivities, have gradually become the main active ingredients in acne treatment cosmetics. Clay products, which provide a cleansing effect by absorbing excess oil and dirt from the skin surface and pores, are gaining increasing attention among acne treatment products due to their unique absorbent properties.

[0004] Currently, various acne treatment products made from natural plant extracts have emerged on the market. However, while existing products avoid the irritation of chemical products to some extent, they often suffer from limited efficacy and insignificant results. Therefore, it is necessary to develop a highly effective, gentle, non-irritating, and soothing compound herbal acne treatment mud paste to meet the market demand for high-quality acne treatment products. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a compound traditional Chinese medicine acne-removing mud paste. This acne-removing mud paste includes a compound traditional Chinese medicine acne-removing component composed of burdock root extract, artemisia annua extract, sage leaf extract, and sophora flavescens extract. The inventors have combined traditional Chinese medicine theory with modern dermatology and formulation technology to develop a compound traditional Chinese medicine acne-removing mud paste that has high safety and excellent acne-removing effect, and is a natural acne-removing product with no side effects even with long-term use.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: On one hand, the present invention provides a compound traditional Chinese medicine acne-removing mud paste, comprising the following components by weight percentage: 10-25% filler matrix, 5-15% compound traditional Chinese medicine acne-removing components, 0.5-2% thickener, 5-15% moisturizer, 0.5-2% preservative, and the balance being deionized water; wherein the compound traditional Chinese medicine acne-removing components are composed of burdock root extract, Artemisia annua extract, Salvia miltiorrhiza leaf extract, and Sophora flavescens extract.

[0007] Preferably, a compound traditional Chinese medicine acne-removing mud paste comprises the following components in weight percentage: 12-20% filler matrix, 8-15% compound traditional Chinese medicine acne-removing components, 0.5-1.5% thickener, 6-12% moisturizer, 0.5-1% preservative, and the balance being deionized water.

[0008] Preferably, the compound Chinese medicine acne-removing component is composed of the following raw materials in parts by weight: 1-5 parts of burdock root extract, 2-8 parts of Artemisia annua extract, 6-12 parts of Sage leaf extract, and 3-5 parts of Sophora flavescens extract.

[0009] Preferably, the compound Chinese medicine acne-removing component is composed of the following raw materials in parts by weight: 2-5 parts of burdock root extract, 3-6 parts of Artemisia annua extract, 8-12 parts of Sage leaf extract, and 3-5 parts of Sophora flavescens extract.

[0010] Preferably, the burdock root extract, artemisia annua extract, and sophora flavescens extract are water extracts, and the sage leaf extract is an alcohol extract.

[0011] Preferably, the sage leaf extract is an extract obtained by extracting sage leaves with 70%-95% ethanol.

[0012] Preferably, the alcohol extract is obtained by conventional extraction with 70%-95% ethanol.

[0013] Preferably, the extraction method of the alcohol extract includes crushing the leaves of Sage officinalis, adding 4-10 times the weight of an aqueous ethanol solution with a concentration of 70%-95% to a container, heating and extracting for 2-5 hours, filtering to obtain the filtrate, concentrating and drying to obtain the Sage officinalis leaf extract.

[0014] Preferably, the burdock root extract, artemisia annua extract, and sophora flavescens extract are all extracts obtained by water extraction.

[0015] Preferably, the water extract can be obtained by conventional extraction methods, specifically including soaking burdock root, Artemisia annua and Sophora flavescens separately, adding 5-10 times their weight of water, heating and extracting for 2-5 hours, filtering to obtain the filtrate, concentrating and drying to obtain the extract.

[0016] Preferably, the filling matrix includes one or more of kaolin, bentonite, mung bean powder, mother-of-pearl powder, or pearl powder.

[0017] Preferably, the moisturizer includes one or more of propylene glycol, glycerin, butylene glycol, allantoin, or hyaluronic acid.

[0018] Preferably, the thickener includes one or more of hydroxyethyl ethyl cellulose, xanthan gum, and carbomer 940.

[0019] Preferably, the preservative includes one or more of methylparaben, ethylparaben, phenoxyethanol, and ethylhexylglycerin.

[0020] On the other hand, the present invention provides a method for preparing a compound traditional Chinese medicine acne-removing mud paste, characterized in that the preparation method includes the following steps: (1) Mix deionized water and thickener, heat and stir to obtain mixture A; (2) Mix the moisturizer with the compound Chinese medicine acne-removing components, preheat and stir to obtain mixture B; (3) Mix mixture A and mixture B and homogenize them. Slowly add the filling matrix and stir thoroughly to obtain mixture C. (4) Add preservative to mixture C and stir evenly to obtain the mud paste.

[0021] Preferably, the heating temperature in step (1) is 70-85℃. Preferably, the preheating temperature in step (2) is 30-60℃. Preferably, the stirring time in step (1) is 10-20 minutes. Preferably, the stirring time in step (2) is 8-15 minutes.

[0022] On the other hand, the present invention provides an application of a compound Chinese herbal acne-removing mud paste in the preparation of skin care products with acne-removing and soothing effects.

[0023] The beneficial effects of this invention are as follows: This invention provides a compound traditional Chinese medicine acne-removing mud paste, which uses burdock root extract, artemisia annua extract, sage leaf extract, and sophora flavescens extract, scientifically formulated to form active components for acne removal. Burdock root extract has significant anti-inflammatory and antioxidant capabilities, effectively inhibiting the release of inflammatory factors and quickly relieving inflammatory symptoms such as redness and swelling of acne. Artemisia annua extract can inhibit sebum secretion from sebaceous gland cells, and also has strong antibacterial, anti-inflammatory, and soothing effects. Sophora flavescens extract has broad-spectrum antibacterial, antifungal, and anti-inflammatory effects, effectively inhibiting excessive sebaceous gland activity, reducing sebum secretion, and directly killing acne-related pathogens. Sage leaf extract has antibacterial, astringent, soothing, and repairing effects, tightening enlarged pores to control excessive sebum secretion, while promoting skin tissue healing and repair, and relieving redness and discomfort caused by acne. The results of this application indicate that the compound Chinese medicine acne-removing components provided by this invention work together to synergistically and effectively inhibit Propionibacterium acnes to control the source of infection, and block the release of inflammatory factors to relieve redness and swelling symptoms.

[0024] The mud-filling matrix physically absorbs excess oil, bacterial metabolites, and dirt from pores, promoting skin metabolism and allowing the skin to better absorb the effective ingredients of traditional Chinese medicine acne-fighting plant extracts. This compound Chinese medicine acne-fighting mud combines the acne-fighting essence of traditional Chinese medicine with modern skincare formulation technology, comprehensively achieving beneficial effects such as good acne-fighting efficacy, gentle and non-irritating properties, and moisturizing and repairing benefits. Detailed Implementation

[0025] To better understand the present invention, the present invention will be further described below with reference to specific application examples. The terminology used in the application examples is for describing specific specific implementations and does not constitute a limitation on the scope of protection of the present invention.

[0026] Unless otherwise specified, experimental methods in the following examples are generally performed under standard conditions or as recommended by the manufacturer. The herbal extracts may be commercially available products or prepared in-house. In-house preparation methods include obtaining water extracts using conventional methods, obtaining alcohol extracts using 70%-95% ethanol using conventional methods, and all other reagents and materials used are commercially available.

[0027] Compound Chinese herbal acne-removing components: The mass proportions of the raw materials in the composition are as follows: Composition 1: It consists of 1 part burdock root extract, 2 parts Artemisia annua extract, 6 parts Sage leaf extract, and 3 parts Sophora flavescens extract.

[0028] The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts, while the Sage leaf extract is an alcohol extract.

[0029] Composition 2: It consists of 5 parts burdock root extract, 8 parts Artemisia annua extract, 12 parts Sage leaf extract, and 5 parts Sophora flavescens extract.

[0030] The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts, while the Sage leaf extract is an alcohol extract.

[0031] Composition 3: It consists of 3 parts burdock root extract, 5 parts Artemisia annua extract, 10 parts Sage leaf extract, and 4 parts Sophora flavescens extract.

[0032] The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts, while the Sage leaf extract is an alcohol extract.

[0033] Composition 4: It consists of 2 parts burdock root extract, 3 parts Artemisia annua extract, 8 parts Sage leaf extract, and 3 parts Sophora flavescens extract.

[0034] The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts, while the Sage leaf extract is an alcohol extract.

[0035] Composition 5: It consists of 2 parts burdock root extract, 3 parts Artemisia annua extract, and 3 parts Sophora flavescens extract.

[0036] The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts.

[0037] Composition 6: It consists of 2 parts burdock root extract, 3 parts Artemisia annua extract, 8 parts Sage leaf extract, and 3 parts Sophora flavescens extract.

[0038] The burdock root extract, Artemisia annua extract, Sophora flavescens extract, and Salvia miltiorrhiza leaf extract are all water extracts.

[0039] Composition 7: It consists of 2 parts burdock root extract, 3 parts coptis extract, 8 parts sage leaf extract, and 3 parts sophora flavescens extract.

[0040] The burdock root extract, coptis extract, and sophora flavescens extract are water extracts, and the sage leaf extract is an alcohol extract.

[0041] Composition 8: The formula consists of 2 parts burdock root extract, 3 parts Artemisia annua extract, 4 parts Sage leaf extract, 4 parts Houttuynia cordata extract, and 3 parts Sophora flavescens extract.

[0042] The burdock root extract, Artemisia annua extract, Sophora flavescens extract, and Houttuynia cordata extract are water extracts, while the Sage leaf extract is an alcohol extract.

[0043] The components and their mass percentages in the compound traditional Chinese medicine acne-removing mud paste of this application are shown in Table 1 below: Table 1. Components and their mass percentage in the compound traditional Chinese medicine acne-removing mud paste.

[0044] Comparison with Application Examples 1-4: The difference between these examples and the previous ones is that the compound Chinese medicine acne treatment compositions 1-4 are replaced with compositions 5-8, otherwise they are the same.

[0045] The preparation method for the above application examples is as follows: (1) Mix deionized water and xanthan gum, heat to 75°C, and stir to obtain mixture A; (2) Mix glycerin, butylene glycol and compound Chinese medicine acne-removing components, preheat to 50°C, stir, and obtain mixture B; (3) After mixing mixture A and mixture B, homogenize them, slowly add kaolin and pearl powder, and stir thoroughly to obtain mixture C; (4) Add phenoxyethanol to mixture C and stir until homogeneous to obtain the mud paste.

[0046] Experiment 1: Antibacterial efficacy test of the composition against Propionibacterium acnes: Test samples: Prepare a sample solution with a concentration of 0.1 g / ml using sterile water (compositions 1-8).

[0047] Experimental Method: Propionibacterium acnes strain was activated and diluted to 1.0 x 10⁶ CFU / mL. 80 μL of bacterial suspension and 20 μL of sample solution were added to each well of a 96-well plate. For the blank control group, an equal volume of sterile water was used instead of the sample solution (sterile water + bacterial suspension). The 96-well plates were incubated anaerobically at 37°C for 48 h. The OD600 nm of the 96-well plates was measured using a microplate reader. The bacterial content in each well was determined based on the absorbance. The inhibition rate of Propionibacterium acnes was calculated using the formula below. The measurement was repeated three times, and the average value was taken. The results are shown in Table 2.

[0048] Antibacterial rate % = (OD value of blank group - OD value of sample group) / OD value of blank group × 100%.

[0049] Table 2. Antibacterial results of the composition against Propionibacterium acnes

[0050] Note: "*" indicates that p < 0.05 compared to composition 4.

[0051] Table 2 shows that the compound acne-removing traditional Chinese medicine compositions 1-4 of this application have a significant inhibitory effect on Propionibacterium acnes, with the inhibition rate remaining stable between 42.97% and 45.16%, indicating that the compound acne-removing components of this application work together to achieve a reliable antibacterial effect. In contrast, the antibacterial rate of composition 5, which lacks the extract of Sage officinalis leaf, is significantly reduced to 35.10%; the antibacterial rate of composition 6, which replaces the ethanol extract of Sage officinalis leaf with the aqueous extract of Sage officinalis leaf, also decreases to 37.45%. This indicates that the extract of Sage officinalis leaf is an indispensable component for exerting the antibacterial effect, and its ethanol extract can extract the effective components with anti-Propionibacterium acnes activity more efficiently. When Coptis chinensis extract is used to replace Artemisia annua extract (composition 7), or Houttuynia cordata extract is added to replace part of the Sage officinalis leaf extract (composition 8), the antibacterial rate also decreases significantly, all significantly lower than the antibacterial effect of compositions 1-4. It can be seen that the absence or replacement of each component in the compound extract of this application will significantly weaken its activity in inhibiting Propionibacterium acnes. Propionibacterium acnes is a key pathogen causing acne. Its proliferation induces inflammatory responses and promotes the breakdown of sebum into free fatty acids, exacerbating follicle blockage. The specific compound Chinese herbal acne-removing components of this invention have a significant inhibitory effect on Propionibacterium acnes, the main pathogen of acne, reducing the microbial burden that causes acne at its source. By effectively inhibiting bacterial proliferation, it achieves the effect of acne removal.

[0052] Experiment 2: Test on the inhibitory efficacy of the composition against inflammatory factors: Test samples: Prepare test samples (compositions 1-8) into a sample solution with a concentration of 0.1 g / ml using PBS.

[0053] Experimental Methods: RAW264.7 macrophages were seeded into 24-well plates and incubated at 37°C in a 5% CO2 incubator for 24 hours. After 24 hours of cell culture in the 24-well plates, samples were added to the experimental groups, which received sample solution and LPS, while the model control group received an equal amount of PBS and LPS. Each treatment group had three replicates. The cells were cultured in the above culture medium at 37°C in a 5% CO2 incubator for another 24 hours, and the supernatant was collected. The cell supernatant from each well was used to detect the content of the inflammatory cytokine IL-1β according to the ELISA kit instructions, and the IL-1β inhibition rate was calculated as follows: IL-1β inhibition rate = (IL-1β content in the model group - IL-1β content in the sample group) / IL-1β content in the model group × 100%. The specific experimental results are shown in Table 3 below.

[0054] Table 3. Inhibition results of the composition on the inflammatory factor IL-1β

[0055] Note: "*" indicates p < 0.05 compared to composition 4; "**" indicates p < 0.01 compared to composition 4.

[0056] Table 3 shows the inhibition rates of different compound traditional Chinese medicine compositions on the inflammatory factor IL-1β. IL-1β is an important inflammatory factor and a key factor driving inflammatory symptoms such as redness, swelling, and pain in acne. Compositions 1-4 of this invention showed inhibition rates of 81.82% to 85.63% on LPS-induced IL-1β secretion in RAW264.7 macrophages, indicating that the compound traditional Chinese medicine acne-removing component has significant anti-inflammatory effects, effectively inhibiting the release of inflammatory factors from macrophages and alleviating acne-related redness and inflammation. However, composition 5, lacking *Salvia miltiorrhiza* leaf extract, showed an IL-1β inhibition rate of only 59.07%, and composition 6, which replaced the ethanol extract of *Salvia miltiorrhiza* leaf with an aqueous extract, also showed a reduction in inhibition rate to 70.13%. The inhibition rate decreased to 62.29% after replacing *Artemisia annua* extract with *Coptis chinensis* extract (composition 7), or to 65.74% after adding *Houttuynia cordata* extract to replace part of the *Salvia miltiorrhiza* leaf extract (composition 8), both significantly lower than the anti-inflammatory effects of the compound traditional Chinese medicine acne-removing component of this application. This indicates that the various components of the compound Chinese medicine acne-removing paste in this application achieve highly efficient inhibition of inflammatory response through a synergistic mechanism involving multiple targets and pathways, thereby effectively enhancing the acne-removing and soothing effects of the acne-removing mud paste.

[0057] Experiment 3: Biosafety Experiment for Application Examples: Volunteers aged 20-35 who met the inclusion criteria were randomly divided into 4 groups of 16 people each. The irritation of cosmetics was evaluated with reference to the 2015 "Cosmetic Safety Technical Specifications". Skin patch tests were conducted on acne-removing face creams corresponding to cases 1-4.

[0058] Test method: Take an appropriate amount of the test substance from Examples 1-4 and place it into the patch applicator. Cover the patch applicator containing the test substance onto the back of the subject with non-irritating cloth-based adhesive tape, and gently press it with the palm of your hand to make it evenly adhere to the skin for 24 hours. Observation was performed at 0.5, 24, and 48 hours after removing the patch applicator during the patch test. The results are shown in Table 4.

[0059] Evaluation criteria: Grade 0: Negative reaction; Grade 1: Suspicious reaction, with only slight erythema; Grade 2: Weak positive reaction, erythema, infiltration, edema, and possible papules; Grade 3: Strong positive reaction, erythema, infiltration, edema, papules may be present, and the reaction may extend beyond the test area; Grade 4: Extremely positive reaction, with obvious erythema, severe infiltration, edema, confluent herpes, and reaction extending beyond the test area.

[0060] Table 4. Skin patch safety test of application examples

[0061] As shown in Table 4 above, all subjects had negative skin reactions, with no positive reactions detected. This indicates that the acne-removing mud paste described in this invention has low skin sensitization, meaning that the acne-removing mud paste is non-irritating to the skin, has mild and safe ingredients, and is suitable for long-term use.

[0062] Experiment 4: Application Example: Human Acne Treatment Efficacy Test Experimental subjects: 128 acne volunteers aged 20-35 (acne grade II) were recruited, who were required to cooperate well with the experiment and maintain a regular lifestyle during the study period. They were randomly divided into 8 groups of 16 people each.

[0063] Experimental samples: Acne-removing mud pastes from Application Examples 1-4 and Comparative Application Examples 1-4 were taken.

[0064] Experimental Methods: Subjects used the acne-removing mud cream every morning and evening for two consecutive weeks. The method of use was as follows: Before using the acne-removing mud cream, cleanse the face with water; apply an appropriate amount of the acne-removing mud cream evenly to the face, leave it on the skin for 10-15 minutes, and then wash the face with water. The efficacy of the subjects after two weeks of use was recorded using the following efficacy evaluation methods, and the significant efficacy rate and total effective rate were calculated. Total effective rate = significant efficacy rate + effective rate. The results are shown in Table 5 below.

[0065] Efficacy assessment: Significant results: Acne has basically disappeared, acne scars have faded significantly, and skin texture is noticeably smooth with no redness or swelling; Effective: Most pimples subsided, acne scars were reduced, skin smoothness improved, and there was no obvious redness or swelling; Ineffective: No significant changes were observed in acne, acne scars, or skin redness and swelling, and no significant improvement was seen in the smoothness of the skin.

[0066] Table 5. Human Acne Treatment Efficacy Test

[0067] As shown in the table above, the acne-removing mud pastes in Examples 1-4 of this invention have good acne-removing effects. Most of the volunteers' acne subsided or essentially disappeared, acne scars faded, skin smoothness improved, and there was no obvious redness or swelling, or even none at all. The significant efficacy and number of effective cases after using the acne-removing mud pastes were significantly better than those in the control examples, with an efficacy rate as high as 87.5%. Compared to the control examples, the acne-removing mud pastes showed a significant improvement in effect, which also confirms the correlation between in vitro antibacterial and anti-inflammatory activity and clinical acne-removing efficacy. It is evident that the acne-removing mud pastes prepared using a specific compound traditional Chinese medicine acne-removing composition as the active ingredient in this application not only solve the problem of acne but also achieve a soothing effect through rapid anti-inflammatory action.

[0068] Those skilled in the art can make various modifications and variations to this invention. If these modifications and variations fall within the scope of the claims of this invention and their equivalents, then this invention also intends to include these modifications and variations.

Claims

1. A compound traditional Chinese medicine acne-removing mud paste, characterized in that, It includes the following components by weight percentage: 10-25% filler matrix, 5-15% compound Chinese herbal acne-removing components, 0.5-2% thickener, 5-15% moisturizer, 0.5-2% preservative, and the balance being deionized water; The compound Chinese medicine acne-removing component consists of burdock root extract, artemisia annua extract, sage leaf extract, and sophora flavescens extract.

2. The compound traditional Chinese medicine acne-removing mud paste as described in claim 1, characterized in that, The compound Chinese medicine acne-removing component is composed of the following raw materials in parts by weight: 1-5 parts of burdock root extract, 2-8 parts of Artemisia annua extract, 6-12 parts of Sage leaf extract, and 3-5 parts of Sophora flavescens extract.

3. The compound traditional Chinese medicine acne-removing mud paste as described in claim 1 or 2, characterized in that, The burdock root extract, Artemisia annua extract, and Sophora flavescens extract are water extracts, while the Sage leaf extract is an alcohol extract.

4. The compound traditional Chinese medicine acne-removing mud paste as described in any one of claims 1-3, characterized in that, The filling matrix includes one or more of kaolin, bentonite, mung bean powder, red bean seed powder, mother-of-pearl powder, or pearl powder.

5. The compound traditional Chinese medicine acne-removing mud paste as described in any one of claims 1-4, characterized in that, The moisturizer includes one or more of propylene glycol, glycerin, butylene glycol, allantoin, or sodium hyaluronate.

6. The compound traditional Chinese medicine acne-removing mud paste as described in any one of claims 1-5, characterized in that, The thickener includes one or more of hydroxyethyl ethyl cellulose, xanthan gum, and carbomer 940.

7. The compound traditional Chinese medicine acne-removing mud paste as described in any one of claims 1-6, characterized in that, The preservatives include one or more of methylparaben, ethylparaben, phenoxyethanol, and ethylhexylglycerin.

8. The preparation method of the compound traditional Chinese medicine acne-removing mud paste according to any one of claims 1-7, characterized in that, The preparation method includes the following steps: (1) Mix deionized water and thickener, heat and stir to obtain mixture A; (2) Mix the moisturizer with the compound Chinese medicine acne-removing components, preheat and stir to obtain mixture B; (3) Mix mixture A and mixture B and homogenize them. Slowly add the filling matrix and stir thoroughly to obtain mixture C. (4) Add preservative to mixture C and stir evenly to obtain the mud paste.

9. The preparation method of the compound traditional Chinese medicine acne-removing mud paste as described in claim 8, characterized in that, The heating temperature in step (1) is 70-85℃, and / or the preheating temperature in step (2) is 30-60℃, and / or the stirring time in step (1) is 10-20 min, and / or the stirring time in step (2) is 8-15 min.

10. The application of the compound Chinese herbal acne-removing mud paste as described in any one of claims 1-7 in the preparation of skin care products with acne-removing and soothing effects.

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