Intelligent feedback intravascular minimally invasive oxygenation device integrating oxygen self-supply and carbon dioxide removal

Abstract

The invention discloses an intelligent feedback intravascular minimally invasive oxygenation device integrating oxygen self-supply and carbon dioxide removal, and relates to the technical field of medical life support equipment. The device comprises a main machine, an oxygen generator and an oxygenation guide pipe, the oxygen generator and the oxygenation guide pipe are arranged in the main machine, the oxygenation guide pipe comprises a central supporting pipe, the air inlet end of the central supporting pipe is communicated with an oxygen outlet of the oxygen generator, and a hollow fiber membrane bundle is wound around the periphery of the central supporting pipe. And the air outlet end of the central supporting pipe is communicated with the air inlet end of the hollow fiber membrane bundle. While the portability of the device is guaranteed, when oxygen passes through the central supporting tube and then is conveyed into the hollow fiber membrane bundle, controllable micro vortexes can be generated, the thickness of invalid laminar flow on the blood side is reduced, meanwhile, the oxygen diffusion efficiency and the carbon dioxide removal efficiency can be improved, and the oxygen diffusion efficiency and the carbon dioxide removal efficiency can be improved while continuous oxygen supply to blood is guaranteed. And retention carbon dioxide in blood is effectively removed, and the oxygen demand of basic metabolism of adult patients is effectively met.

Description

Technical Field

[0001] This application relates to the field of medical life support equipment technology, specifically to an intravascular minimally invasive oxygenation device that integrates self-oxygenation and intelligent feedback. Background Technology

[0002] Refractory hypoxemia caused by acute respiratory distress syndrome (ARDS) is a major challenge in the clinical treatment of critically ill patients, seriously threatening their lives. Currently, extracorporeal membrane oxygenation (ECMO) is the ultimate respiratory support method. While it can save some critically ill patients, it has significant inherent drawbacks: First, the system is open, requiring the patient's blood to be drawn outside the body for oxygenation, leading to a significantly increased risk of bleeding, thrombosis, and infection. Second, it is a resource-intensive device, dependent on the hospital's central oxygen supply system, large supporting facilities, and a professional medical team for operation and maintenance. This not only results in high costs but also extremely poor mobility, making it unsuitable for off-site settings. Third, it provides non-physiological support; the non-pulsatile blood flow pattern and strong anticoagulation requirements can significantly interfere with the patient's physiological state, easily leading to complications. To address these shortcomings of ECMO, minimally invasive oxygenation technologies such as intravascular oxygenation catheters (IVOX) have emerged. Their core idea is to directly exchange gases with the blood through a hollow fiber membrane implanted in a vein, eliminating the need for external blood drawing.

[0003] However, existing minimally invasive oxygenation techniques still face the following drawbacks: First, the problem of oxygen source dependence has not been fundamentally solved. It still requires connection to external oxygen sources such as wall-mounted oxygen or oxygen cylinders, which is not portable enough to meet the needs of scenarios without fixed medical facilities, such as pre-hospital emergency care and disaster relief. Second, the oxygenation efficiency is low. Traditional hollow fiber bundles mostly adopt a parallel design, which limits the gas exchange area within the limited catheter size. Moreover, laminar flow is easily formed when blood flows through, resulting in low oxygen diffusion efficiency, which is difficult to meet the oxygen demand of adult patients' basal metabolism. In addition, in clinical scenarios such as acute respiratory failure and acute exacerbation of chronic obstructive pulmonary disease, patients often have severe hypercapnia. Simply increasing the blood oxygen partial pressure through the oxygenation catheter cannot correct respiratory acidosis. It is necessary to achieve efficient carbon dioxide removal at the same time. However, the existing minimally invasive oxygenation catheters are limited by the performance of membrane materials, gas exchange area and hemodynamic design, resulting in low carbon dioxide removal efficiency, which is difficult to meet the clinical needs for simultaneous oxygenation and ventilation support. Second, the control strategy is crude and lacks an automatic feedback adjustment mechanism based on the patient's real-time physiological status. It can only achieve open-loop fixed oxygen supply, which is prone to situations where the oxygen concentration is too high, leading to oxygen poisoning, or the oxygen concentration is too low, which cannot effectively improve hypoxemia. The safety and effectiveness of treatment are difficult to guarantee. Summary of the Invention

[0004] In view of the deficiencies in the existing technology, the technical problem to be solved by this application is: how to achieve convenient oxygen supply and efficient carbon dioxide removal while ensuring the safety and effectiveness of oxygen supply, and improve oxygenation efficiency.

[0005] To achieve the above objectives, this application provides an intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal, comprising a main unit, an oxygen generator and an oxygenation catheter disposed within the main unit. The oxygenation catheter includes a central support tube, the inlet end of which is connected to the oxygen outlet of the oxygen generator. A hollow fiber membrane bundle is wound around the outer periphery of the central support tube, and the outlet end of the central support tube is connected to the inlet end of the hollow fiber membrane bundle. An exhaust control valve is provided at the outlet end of the hollow fiber membrane bundle.

[0006] In one embodiment, the oxygenation catheter is made of medical-grade polyurethane with a diameter ranging from 12Fr to 18Fr.

[0007] In one embodiment, the hollow fiber membrane bundle is provided with 5,000-15,000 strands, and the hollow fiber membrane bundle is made of PMP material.

[0008] In one embodiment, the spiral angle of the hollow fiber membrane bundle is 45°, and the ratio of the spiral pitch to the diameter of the hollow fiber membrane bundle is 1.5–2.5.

[0009] In one embodiment, the hollow fiber membrane bundle has an oxygen and carbon dioxide selective permeability ratio ≥3.5, an oxygen permeability ≥2000 Barrer, an inner diameter of 0.15mm-0.25mm, and a wall thickness of 20μm–40μm.

[0010] In one embodiment, the outer surface of the hollow fiber membrane bundle is covalently grafted with a carbonic anhydrase-inspired coating.

[0011] In one embodiment, the oxygen generator includes a filter, a compressor, a dual-tower micro molecular sieve pressure swing adsorption module, and an oxygen storage tank connected in sequence. The oxygen storage tank is connected to the air inlet of the central support pipe via an electronically controlled proportional valve.

[0012] In one embodiment, a constant temperature humidifier is also provided at the connection section between the oxygen storage tank and the central support pipe.

[0013] In one embodiment, the host computer further includes a control unit, which is communicatively connected to a multi-parameter acquisition module. The multi-parameter acquisition module is used to acquire oxygen supply pressure, oxygen concentration, real-time blood oxygen saturation, real-time arterial blood oxygen partial pressure, real-time mixed venous blood oxygen saturation, real-time arterial blood carbon dioxide partial pressure, and real-time end-tidal carbon dioxide concentration.

[0014] In one embodiment, the multi-parameter acquisition module includes: SpO2 monitoring module, which is used to collect the patient's real-time blood oxygen saturation; PaO2 monitoring module, which is used to collect the patient's real-time arterial blood oxygen partial pressure; ScvO2 monitoring module, which is used to collect the patient's real-time mixed venous blood oxygen saturation; PaCO2 monitoring module, which is used to collect the patient's real-time arterial blood carbon dioxide partial pressure; EtCO2 monitoring module, which is used to collect the patient's real-time end-tidal carbon dioxide concentration; An oxygenation catheter pressure sensor is installed in the central support tube to collect the oxygen supply pressure inside the oxygenation catheter. An oxygen concentration sensor is installed in an oxygen storage tank to collect the oxygen concentration of the oxygen stored inside the tank.

[0015] Compared with the prior art, the advantages of this application are: (1) By using an oxygen generator to provide oxygen source to get rid of dependence on external oxygen source, the portability of the device is guaranteed. When oxygen is delivered to the hollow fiber membrane bundle after passing through the central support tube, a controllable micro vortex can be generated. While reducing the thickness of ineffective laminar flow on the blood side, it can also improve the oxygen diffusion efficiency and carbon dioxide removal efficiency. The high permeability and selective permeation characteristics of the hollow fiber membrane bundle can realize the diffusion of oxygen into the blood and the reverse diffusion of carbon dioxide from the blood into the hollow fiber membrane bundle. Then, the waste gas containing carbon dioxide is directly discharged through the outlet of the hollow fiber membrane bundle. While ensuring continuous oxygen supply to the blood, it effectively removes the carbon dioxide retained in the blood and effectively meets the oxygen demand of the basal metabolism of adult patients.

[0016] (2) By using the controller to collect real-time data on oxygen supply pressure, oxygen concentration, blood oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, arterial blood carbon dioxide partial pressure and end-tidal carbon dioxide concentration, the oxygen concentration, oxygen output flow rate and carbon dioxide emission can be intelligently adjusted, realizing the transformation from fixed oxygen supply to dynamic oxygen supply for individual patients, effectively avoiding the risk of oxygen poisoning or insufficient support, improving the safety and effectiveness of treatment, and reducing iatrogenic damage. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a block diagram illustrating the working principle of the controller regulating oxygen supply in the embodiments of this application; Figure 2 This is a schematic diagram of the host architecture in an embodiment of this application. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0020] The flowchart shown in the attached diagram is for illustrative purposes only and does not necessarily include all content and operations / steps, nor does it necessarily have to be performed in the order described. For example, some operations / steps can be broken down, combined, or partially merged, so the actual execution order may change depending on the actual situation.

[0021] To make the objectives, technical solutions, and advantages of this application clearer, the embodiments of this application will be described in further detail below with reference to the accompanying drawings.

[0022] This invention provides an intelligent feedback intravascular minimally invasive oxygenation device that integrates self-oxygenation and carbon dioxide removal. The device includes an oxygen generator and an oxygenation catheter. The oxygenation catheter is made of medical-grade polyurethane and has a diameter range of 12Fr-18Fr. The oxygenation catheter includes a central support tube, the inlet of which is connected to the oxygen outlet of an oxygen concentrator. The outer circumference of the central support tube is wound with 5000-15000 PMP hollow fiber membrane bundles at a spiral angle of 45°. The ratio of the spiral pitch to the diameter of the hollow fiber membrane bundles is 1.5–2.5, forming a spiral flow channel in the blood to enhance the transmembrane exchange efficiency of oxygen and carbon dioxide. The inner diameter of the hollow fiber membrane bundles is 0.15mm-0.25mm, and the wall thickness is 20μm–40μm. The outlet of the central support tube is connected to the inlet of the hollow fiber membrane bundles; this connection point serves as the tip of the oxygenation catheter, which is percutaneously inserted into the inferior vena cava. The outlet of the hollow fiber membrane bundles is equipped with an exhaust control valve (a one-way exhaust valve). The oxygen and carbon dioxide selective permeability ratio of the hollow fiber membrane bundles is ≥3.5, with an oxygen permeability ≥2000 Barrer and a carbon dioxide permeability ≥8000 Barrer. Barrer provides the basis for the diffusion of oxygen into the blood and the reverse diffusion of carbon dioxide from the blood into the hollow fiber membrane bundle. When blood flows through the surface of the hollow fiber membrane bundle, the carbon dioxide dissolved in the blood is rapidly passed through the membrane wall of the hollow fiber membrane bundle into the inner cavity of the hollow fiber membrane bundle due to the partial pressure difference (blood side > hollow fiber membrane bundle), and is discharged through the exhaust control valve with the airflow.

[0023] This method utilizes an oxygen generator to provide an oxygen source, eliminating dependence on external oxygen sources and ensuring the portability of the device. When oxygen is delivered to the hollow fiber membrane bundle after passing through the central support tube, it can generate controllable micro-vortices, reducing the ineffective laminar flow thickness on the blood side while improving oxygen diffusion efficiency and carbon dioxide removal efficiency. The high permeability and selective permeation characteristics of the hollow fiber membrane bundle enable oxygen diffusion into the blood and carbon dioxide reverse diffusion from the blood into the hollow fiber membrane bundle. Then, the waste gas containing carbon dioxide is directly discharged through the outlet end of the hollow fiber membrane bundle. While ensuring continuous oxygen supply to the blood, it effectively removes carbon dioxide retained in the blood, effectively meeting the basal metabolic oxygen demand of adult patients.

[0024] Furthermore, the outer surface of the hollow fiber membrane bundle is covalently grafted with a carbonic anhydrase-inspired coating, which can catalyze the reaction of HCO3- in the blood. - It is converted into CO2, accelerating the release and removal of carbon dioxide. When this coating is used, under the condition of blood flow rate of 2L / min–4L / min, the carbon dioxide removal rate (calculated based on the carbon dioxide concentration difference of the gas discharged in the hollow fiber membrane bundle and the blood flow rate) can reach 50mL / min–120mL / min, which is sufficient to correct moderate to severe hypercapnia.

[0025] In one embodiment, the oxygen generator includes a filter (selected as a HEPA high-efficiency particulate filter), a compressor (selected as an oil-free micro scroll compressor), a dual-tower micro molecular sieve pressure swing adsorption module, and an oxygen storage tank (volume of 0.5L) connected in sequence.

[0026] For the dual-tower micro molecular sieve pressure swing adsorption module, the molecular sieve is made of LiX zeolite, the molecular sieve tower volume is <2L, and rapid pressure swing is achieved by integrating a micro solenoid valve.

[0027] The oxygen production process of the aforementioned oxygen concentrator includes: The compressor is started, and the ambient air is initially purified by the filter. It is then pressurized to 0.3MPa-0.5MPa by the compressor and then sent to the dual-tower micro molecular sieve pressure swing adsorption module to separate and produce oxygen with an oxygen concentration of ≥93% and an adjustable flow rate of 1-5L / min. The oxygen is then stored in the oxygen storage tank.

[0028] Furthermore, the oxygen in the oxygen storage tank needs to be regulated by an electronically controlled proportional valve before being fed into the central support pipe for controlled oxygen supply.

[0029] Therefore, by integrating a dual-tower micro molecular sieve pressure swing adsorption module for oxygen production, high-purity oxygen can be directly produced from ambient air in real time, completely eliminating the dependence on external oxygen sources. Combined with a lightweight, portable host and a built-in long-lasting lithium-ion battery, the device can operate independently of hospital central medical facilities.

[0030] In one embodiment, the device further includes a control unit (based on an ARM Cortex-M7 microcontroller and equipped with a high-precision analog-to-digital converter), which is communicatively connected to a multi-parameter acquisition module, and performs oxygen supply regulation based on data acquired by the multi-parameter acquisition module; wherein the multi-parameter acquisition module includes: SpO2 monitoring module, the SpO2 monitoring module is used to collect the patient's real-time blood oxygen saturation; PaO2 monitoring module, used to collect real-time arterial blood oxygen partial pressure of patients; The ScvO2 monitoring module is used to collect real-time mixed venous blood oxygen saturation of patients. PaCO2 monitoring module, which is used to collect the patient's real-time arterial blood carbon dioxide partial pressure; EtCO2 monitoring module, which is used to collect the patient's real-time end-tidal carbon dioxide concentration; Oxygenation catheter pressure sensor: The oxygenation catheter pressure sensor is installed in the central support tube and is used to collect the oxygen supply pressure inside the oxygenation catheter. An oxygen concentration sensor is installed inside an oxygen storage tank to collect the oxygen concentration of the stored oxygen.

[0031] Before the controller adjusts the oxygen supply based on the data collected by the multi-parameter acquisition module, it presets safe thresholds for blood oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, arterial blood carbon dioxide partial pressure, and end-tidal carbon dioxide concentration. The safe threshold for end-tidal carbon dioxide concentration is the automatic opening threshold of the exhaust control valve.

[0032] Based on this, refer to Figure 1 , Figure 1 This is a block diagram illustrating the working principle of the control unit for oxygen supply regulation. The methods by which the control unit regulates oxygen supply based on data collected by the multi-parameter acquisition module include: The multi-parameter acquisition module collects oxygen supply pressure, oxygen concentration, real-time blood oxygen saturation, real-time arterial blood oxygen partial pressure, real-time mixed venous blood oxygen saturation, real-time arterial blood carbon dioxide partial pressure, and real-time end-tidal carbon dioxide concentration, and transmits them to the controller. The controller calculates the deviation and rate of change of real-time blood oxygen saturation, real-time arterial blood oxygen partial pressure, real-time mixed venous blood oxygen saturation, real-time arterial blood carbon dioxide partial pressure, and real-time end-tidal carbon dioxide concentration from the corresponding target threshold. The deviation and the rate of change of deviation are input into the fuzzy PID controller. The fuzzy PID controller outputs a concentration control signal containing the oxygen concentration adjustment, a flow control signal containing the oxygen supply flow rate adjustment, and an exhaust control signal. After receiving the concentration control signal, the dual-tower micro molecular sieve pressure swing adsorption module adjusts its own circulation frequency according to the oxygen concentration adjustment amount.

[0033] After receiving the flow control signal, the electronically controlled proportional valve adjusts its opening degree according to the oxygen supply flow rate adjustment to achieve oxygen output flow rate control. The exhaust control valve opens after receiving the exhaust control signal to achieve exhaust emission control (that is, when the real-time end-tidal carbon dioxide concentration is higher than the set safe threshold for end-tidal carbon dioxide concentration, the electronically controlled proportional valve opens automatically to discharge carbon dioxide-containing exhaust gas from the body).

[0034] Furthermore, if the partial pressure of carbon dioxide in arterial blood remains above 50 mmHg or the real-time end-tidal carbon dioxide concentration is below the set safe threshold for end-tidal carbon dioxide concentration, the oxygen output flow rate is increased or the ventilation pressure within the hollow fiber membrane is adjusted to improve carbon dioxide clearance efficiency. If the real-time arterial blood carbon dioxide partial pressure is below 35 mmHg, reduce the oxygen output flow rate to prevent excessive clearance from causing respiratory alkalosis.

[0035] This enables dual closed-loop intelligent regulation of oxygenation and ventilation, which can correct hypoxemia and effectively control hypercapnia, achieving more physiological respiratory support.

[0036] By using a controller to intelligently adjust oxygen concentration, oxygen output flow rate, and carbon dioxide emissions based on real-time data collected from oxygen supply pressure, oxygen concentration, blood oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, arterial blood carbon dioxide partial pressure, and end-tidal carbon dioxide concentration, the system can shift from fixed oxygen supply to dynamic oxygen supply tailored to individual patients. This effectively avoids the risk of oxygen toxicity or insufficient support, improves treatment safety and effectiveness, and reduces iatrogenic injury.

[0037] In one embodiment, the device further includes a host computer, as shown in reference to... Figure 2 , Figure 2 This is a schematic diagram of the main unit's architecture. The oxygen generator and control unit are both fixedly installed inside the main unit. The main unit adopts a lightweight alloy frame and an engineering plastic composite shell. The overall dimensions are <400mm×300mm×200mm, and the weight is <15kg. It is equipped with a telescopic rod and wheels, and has a built-in high-energy-density lithium-ion battery pack that supports ≥4 hours of continuous full-power operation.

[0038] Furthermore, the main unit is equipped with a 7-inch touchscreen for visualizing data such as oxygen flow rate, oxygen concentration, blood oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, arterial blood carbon dioxide partial pressure, end-tidal carbon dioxide concentration, and trend graphs.

[0039] In one embodiment, a constant temperature humidifier (34°C) is also provided at the connection section between the oxygen storage tank and the oxygenation conduit. The constant temperature humidifier is used to humidify the oxygen output from the oxygen storage tank, so as to ensure that the humidity and temperature of the oxygen delivered to the oxygenation conduit are more in line with the patient's body temperature.

[0040] In summary, the intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal provided in this application has the following application scenarios when applied to intravascular minimally invasive oxygenation therapy: treatment of acute respiratory distress syndrome, supportive treatment for acute exacerbations of chronic obstructive pulmonary disease, respiratory support during high-risk percutaneous coronary intervention, perioperative bridging therapy for lung transplantation, pre-hospital emergency care, and respiratory support in resource-scarce scenarios such as battlefields and disaster areas. This effectively expands the application scenarios of the device.

[0041] The terms "comprising" and "having," and any variations thereof, in the specification, claims, and accompanying drawings of this application are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to such process, method, product, or apparatus. The terms "first," "second," and "third," etc., are used to distinguish different objects, etc., and do not indicate a sequence, nor do they limit "first," "second," and "third" to different types.

[0042] In the description of the embodiments of this application, terms such as "exemplary," "for example," or "for instance" are used to indicate examples, illustrations, or explanations. Any embodiment or design described as "exemplary," "for example," or "for instance" in the embodiments of this application should not be construed as being more preferred or advantageous than other embodiments or designs. Specifically, the use of terms such as "exemplary," "for example," or "for instance" is intended to present the relevant concepts in a concrete manner.

[0043] In the description of the embodiments of this application, unless otherwise stated, " / " means "or". For example, A / B can mean A or B. The "and / or" in the text is merely a description of the relationship between related objects, indicating that there can be three relationships. For example, A and / or B can mean: A exists alone, A and B exist simultaneously, and B exists alone. In addition, in the description of the embodiments of this application, "multiple" means two or more.

[0044] In some processes described in the embodiments of this application, multiple operations or steps are included in a specific order. However, it should be understood that these operations or steps may not be executed in the order they appear in the embodiments of this application, or they may be executed in parallel. The sequence number of the operation is only used to distinguish different operations, and the sequence number itself does not represent any execution order. In addition, these processes may include more or fewer operations, and these operations or steps may be executed sequentially or in parallel, and these operations or steps may be combined.

[0045] Through the above description of the embodiments, those skilled in the art can clearly understand that the methods of the above embodiments can be implemented by means of software plus necessary general-purpose hardware platforms. Of course, they can also be implemented by hardware, but in many cases the former is a better implementation method. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product is stored in a storage medium (such as ROM / RAM, magnetic disk, optical disk) as described above, and includes several instructions to cause a terminal device to execute the methods described in the various embodiments of this application.

[0046] The above are merely specific embodiments of this application, but the protection scope of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the protection scope of this application. Therefore, the protection scope of this application should be determined by the scope of the claims.

Claims

1. A smart feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal, comprising a main unit, and an oxygen generator and oxygenation catheter disposed within the main unit, characterized in that, The oxygenation conduit includes a central support tube, the air inlet of which is connected to the oxygen outlet of the oxygen generator. A hollow fiber membrane bundle is wound around the outer periphery of the central support tube, and the air outlet of the central support tube is connected to the air inlet of the hollow fiber membrane bundle. An exhaust control valve is provided at the air outlet of the hollow fiber membrane bundle.

2. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The oxygenation catheter is made of medical-grade polyurethane and has a diameter range of 12Fr-18Fr.

3. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The hollow fiber membrane bundle has 5,000-15,000 strands and is made of PMP material.

4. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The spiral angle of the hollow fiber membrane bundle is 45°, and the ratio of the spiral pitch to the diameter of the hollow fiber membrane bundle is 1.5–2.

5.

5. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The hollow fiber membrane bundle has an oxygen and carbon dioxide selective permeability ratio ≥3.5 and an oxygen permeability ≥2000 Barrer. The hollow fiber membrane bundle has an inner diameter of 0.15mm-0.25mm and a wall thickness of 20μm-40μm.

6. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The outer surface of the hollow fiber membrane bundle is covalently grafted with a carbonic anhydrase-inspired coating.

7. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 1, characterized in that, The oxygen generator includes a filter, a compressor, a dual-tower micro molecular sieve pressure swing adsorption module, and an oxygen storage tank connected in sequence. The oxygen storage tank is connected to the air inlet of the central support pipe via an electronically controlled proportional valve.

8. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 7, characterized in that, The connection between the oxygen storage tank and the central support pipe is also equipped with a constant temperature humidifier.

9. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 7, characterized in that, The host also includes a control unit, which is communicatively connected to a multi-parameter acquisition module. The multi-parameter acquisition module is used to acquire oxygen supply pressure, oxygen concentration, real-time blood oxygen saturation, real-time arterial blood oxygen partial pressure, real-time mixed venous blood oxygen saturation, real-time arterial blood carbon dioxide partial pressure, and real-time end-tidal carbon dioxide concentration.

10. The intelligent feedback intravascular minimally invasive oxygenation device integrating self-oxygenation and carbon dioxide removal as described in claim 9, characterized in that, The multi-parameter acquisition module includes: SpO2 monitoring module, which is used to collect the patient's real-time blood oxygen saturation; PaO2 monitoring module, which is used to collect the patient's real-time arterial blood oxygen partial pressure; ScvO2 monitoring module, which is used to collect the patient's real-time mixed venous blood oxygen saturation; PaCO2 monitoring module, which is used to collect the patient's real-time arterial blood carbon dioxide partial pressure; EtCO2 monitoring module, which is used to collect the patient's real-time end-tidal carbon dioxide concentration; An oxygenation catheter pressure sensor is installed in the central support tube to collect the oxygen supply pressure inside the oxygenation catheter. An oxygen concentration sensor is installed in an oxygen storage tank to collect the oxygen concentration of the oxygen stored inside the tank.

Images