Microsphere emulsification equipment used in sterile isolator

Abstract

The invention relates to the technical field of material mixing and emulsifying equipment, and discloses microsphere emulsifying equipment used in a sterile isolator, the microsphere emulsifying equipment comprises a bottom frame, the top of the bottom frame is fixedly connected with an emulsifying tank, the top of the emulsifying tank is fixedly connected with a sealing cover, and the right side of the outer wall of the emulsifying tank is communicated with a transmission pipe; the bottom of the sealing cover is fixedly connected with an emulsification functional layer, a self-adaptive mechanism is arranged on the outer wall of the conveying pipe and used for conducting self-adaptive adjustment on the pressure at the joint of the conveying pipe, flow sterile emulsification operation is achieved through a PLC, after the conveying pipe is in butt joint, an annular air bag at the joint of the conveying pipe is inflated and expands to form tight sealing, and the conveying pipe is in butt joint with the annular air bag. The sealing structure has the pressure self-adaptive adjusting capacity, the inflation amount is automatically adjusted when pressure fluctuation is caused by operation, the ultraviolet plate on the outer side of the air bag irradiates a gap area and inactivates microorganisms, and the whole mechanism achieves sterile sealing of a connector and self-adaptive pressure adjustment of the pipe end.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of material mixing and emulsification equipment, in particular to a microsphere emulsification equipment used in a sterile isolator. BACKGROUND

[0002] The microsphere emulsification equipment is a precision instrument for preparing micron or nanometer microspheres, and the microsphere emulsification equipment realizes the dispersion and emulsification of liquid droplets through high-speed shearing or high-pressure homogenization. Such equipment has important application value in the fields of pharmaceuticals and biological materials. In view of the special requirements of sterile production, the microsphere emulsification equipment designed for the isolator adopts a fully enclosed structure, which can completely avoid external pollution and ensure that the entire preparation process is safely carried out under strict sterile conditions.

[0003] The traditional microsphere emulsification equipment mixes and disperses incompatible fluids by mechanical stirring or high-speed shearing, so as to form a microsphere emulsion with uniform size. However, the traditional method has some inherent shortcomings, and the particle size distribution range of the obtained microspheres is wide. In order to overcome these shortcomings, the microsphere emulsification equipment of the prior art works on the principle of microfluidics, and uses a precisely processed microchannel structure to generate microspheres with good monodispersity through the shearing action of two-phase fluids in a laminar flow state. However, in actual use, the above-mentioned device lacks a self-adaptive pressure adjusting mechanism between the pipes, so that the fluid pressure will change suddenly during the conveying process. The pressure impact will directly act on the microfluidic chip and the connecting pipeline, which will cause irreversible damage to the precision components during long-term operation, seriously affecting the stability and service life of the equipment. SUMMARY

[0004] In view of the shortcomings of the prior art, the present application provides a microsphere emulsification equipment used in a sterile isolator, which solves the problem of reduced service life of the device caused by sudden change of fluid pressure during the conveying process.

[0005] To achieve the above purpose, the following technical scheme is adopted: a microsphere emulsification equipment used in a sterile isolator, comprising a chassis, a top of the chassis is fixedly connected with an emulsification tank, a top of the emulsification tank is fixedly connected with a sealing cover, a right side of an outer wall of the emulsification tank is communicated with a transmission pipe, a bottom of the sealing cover is fixedly connected with an emulsification function layer, an outer wall of the transmission pipe is provided with a self-adaptive mechanism, the self-adaptive mechanism is used for self-adaptive adjustment of the pressure at the connection of the transmission pipe, an outer wall of the chassis is provided with an integration mechanism, the integration mechanism is used for sterile operation of the cleaning and sterilization process, an outer wall of the sealing cover is provided with a coating mechanism, the coating mechanism is used for reducing the adhesion of the material and the film surface;

[0006] The self-adapting mechanism comprises a limiting ring, an inner wall of the limiting ring is fixedly connected to an outer wall of the transmission pipe, an outer wall of the transmission pipe is fixedly connected with an annular air bag, an outer wall of the transmission pipe is fixedly connected with a plurality of connecting rods, distal ends of the plurality of connecting rods are fixedly connected with a ring plate, an inner wall of the ring plate is fixedly connected with an ultraviolet plate, an outer wall of the annular air bag is provided with a monitoring assembly, the monitoring assembly comprises a hoop, an inner wall of the hoop is fixedly connected to an outer wall of the transmission pipe, a top of the hoop is fixedly connected with a pressure sensor, an outer wall of the chassis is provided with an inflation assembly.

[0007] Preferably, the integration mechanism comprises a clean water tank, an outer wall of the clean water tank is fixedly connected to an outer wall of the chassis, a top of the clean water tank is communicated with a mountain-shaped pipe, an outer wall of the mountain-shaped pipe is fixedly connected with a non-return valve, a bottom end of the mountain-shaped pipe is communicated with an acid tank, an outer wall of the mountain-shaped pipe is communicated with an alkaline tank, a bottom of the sealing cover is fixedly connected with a ring pipe, an outer wall of the ring pipe is fixedly connected with a plurality of spray guns, an outer wall of the chassis is fixedly connected with a generating assembly, an outer wall of the chassis is fixedly connected with a transmission assembly, an outer wall of the emulsifying tank is provided with a filtering assembly, an outer wall of the chassis is provided with a flushing assembly.

[0008] Preferably, the coating mechanism comprises a transition bonding layer, an inner wall of the transition bonding layer is fixedly connected to an outer wall of the emulsifying functional layer, the inner wall of the transition bonding layer is fixedly connected with a modified layer, the modified layer is fixedly connected with active sites, an outer wall of the active sites is provided with a plurality of micropores.

[0009] Preferably, the monitoring assembly comprises a hoop, an inner wall of the hoop is fixedly connected to an outer wall of the transmission pipe, a top of the hoop is fixedly connected with a pressure sensor.

[0010] Preferably, the inflation assembly comprises an air tank, an outer wall of the air tank is fixedly connected to an outer wall of the chassis, a top of the air tank is communicated with an inflation pipe, an outer wall of the inflation pipe is fixedly connected with a solenoid valve.

[0011] Preferably, the generating assembly comprises a steam generator, an outer wall of the steam generator is fixedly connected to an outer wall of the chassis, a top of the steam generator is communicated with a flow guide pipe, a top of the chassis is communicated with a high-temperature-resistant air pump, an outer wall of the high-temperature-resistant air pump is communicated with a steam inlet pipe, a top of the high-temperature-resistant air pump is communicated with a steam outlet pipe.

[0012] Preferably, the transmission assembly comprises a water pump one, an outer wall of the water pump one is fixedly connected to an outer wall of the chassis, an outer wall of the water pump one is communicated with a water outlet pipe.

[0013] Preferably, the filtering assembly comprises a filtering box, the outer wall of the filtering box is fixedly connected to the outer wall of the chassis, the outer wall of the filtering box is fixedly connected with an inflow pipe, and the outer wall of the filtering box is fixedly connected with an outflow pipe.

[0014] Preferably, the flushing assembly comprises a water pump two, the outer wall of the water pump two is fixedly connected to the outer wall of the chassis, the top of the water pump two is communicated with a communication pipe one, and the outer wall of the water pump two is communicated with a communication pipe two.

[0015] Preferably, the bottom of the sealing cover is fixedly connected with a support layer, the outer wall of the sealing cover is communicated with a U-shaped pipe, and the top of the chassis is fixedly provided with a liquid storage tank.

[0016] The application provides a microsphere emulsification device used in a sterile isolator.

[0017] 1、The application realizes process sterilization emulsification operation through a PLC controller, when the transmission pipe is docked, the annular air bag at the interface is inflated to form a tight seal, the sealing structure has a pressure self-adaptive adjustment capability, can monitor and link the internal pressure in real time, automatically adjusts the inflation amount when the operation causes pressure fluctuation, so that the sealing pressure always remains stable, the ultraviolet plate outside the air bag irradiates the gap area to inactivate microorganisms, and the whole mechanism realizes the sterile sealing of the interface and the self-adaptive pressure adjustment of the pipe end.

[0018] 2、In the emulsification process, the device will automatically switch to the self-cleaning mode periodically, the residual slag is preliminarily removed through the injection of cleaning liquid, the internal cleaning is maintained, when the sensor monitors that the pollution is intensified, the integrated fresh water tank, acid tank and alkaline tank are called according to the preset program, so that the heated alkaline, acid cleaning liquid and sterile water are pumped into the cavity in turn for closed loop circulation, complete chemical cleaning is realized, then high-pressure steam is introduced to sterilize all contact surfaces, and the sterile state is ensured.

[0019] 3、The application forms a water film on the membrane surface through a special brush-shaped structure, effectively reduces the adhesion of the material, the micropore design is matched with the cleaning channel, when backflushing, the cleaning liquid can fully penetrate and cooperate with the brush-shaped structure to remove the residual slag on the membrane surface, so that the deposition of pollutants is reduced, and the cleaning efficiency and emulsification effect are improved. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a perspective view of the application;

[0021] Figure 2 It is a right view of the application;

[0022] Figure 3 It is a left view of the application;

[0023] Figure 4This is a top view of the present invention;

[0024] Figure 5 This is a cross-sectional view of the annular plate of the present invention;

[0025] Figure 6 This is a cross-sectional view of the emulsification tank of the present invention;

[0026] Figure 7 for Figure 6 Enlarged view of point A;

[0027] Figure 8 This is a cross-sectional view of the emulsifying functional layer of the present invention.

[0028] The components include: 1. Base frame; 2. Emulsifying tank; 3. Sealing cap; 4. Transfer pipe; 5. Adaptive mechanism; 501. Limiting ring; 502. Annular airbag; 503. Connecting rod; 504. Ring plate; 505. Ultraviolet plate; 506. Monitoring component; 5061. Pressure sensor; 5062. Hoop ring; 507. Inflation component; 5071. Solenoid valve; 5072. Inflation pipe; 5073. Gas tank; 6. Integration mechanism; 601. Clean water tank; 602. Z-shaped pipe; 603. Check valve; 604. Acid tank; 605. Alkaline tank; 606. Generating component; 6061. Steam generator; 6062. Guide pipe; 6063, Steam inlet pipe; 6064, High-temperature resistant air pump; 6065, Steam outlet pipe; 607, Transmission assembly; 6071, Water outlet pipe; 6072, Water pump one; 608, Filter assembly; 6081, Inlet pipe; 6082, Filter box; 6083, Outlet pipe; 609, Flushing assembly; 6091, Water pump two; 6092, Connecting pipe one; 6093, Connecting pipe two; 610, Ring pipe; 611, Spray gun; 7, Coating mechanism; 701, Transition bonding layer; 702, Modified layer; 703, Active site; 704, Micropores; 8, Support layer; 9, U-shaped tube; 10, Emulsifying functional layer; 11, Storage tank. Detailed Implementation

[0029] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Please see the appendix Figure 3 -Appendix Figure 5This invention provides a microsphere emulsification device for use in a sterile isolator, comprising a base frame 1, an emulsification tank 2 fixedly connected to the top of the base frame 1, the emulsification tank 2 being used to ensure material compatibility during the emulsification process, a sealing cap 3 fixedly connected to the top of the emulsification tank 2, the sealing cap 3 providing a sealed environment for the emulsification process, a transfer pipe 4 connected to the right side of the outer wall of the emulsification tank 2, the transfer pipe 4 serving as a channel for steam flow during sterilization, an emulsification functional layer 10 fixedly connected to the bottom of the sealing cap 3, the emulsification functional layer 10 being used to form a microsphere emulsion with uniform particle size and stable morphology, and an adaptive mechanism 5 provided on the outer wall of the transfer pipe 4, the adaptive mechanism 5 being used to... The pressure at the connection of the transmission tube 4 is adaptively adjusted. The outer wall of the base frame 1 is provided with an integration mechanism 6, which is used for aseptic operation of the cleaning and sterilization process. The outer wall of the sealing cap 3 is provided with a coating mechanism 7, which includes a transition bonding layer 701. The inner wall of the transition bonding layer 701 is fixedly connected to the outer wall of the emulsifying functional layer 10. The inner wall of the transition bonding layer 701 is fixedly connected to a modified layer 702. The modified layer 702 is fixedly connected to an active site 703. The outer wall of the active site 703 has multiple micropores 704. The coating mechanism 7 is used to reduce the adhesion between the material and the membrane surface.

[0031] The adaptive mechanism 5 includes a limiting ring 501. The inner wall of the limiting ring 501 is fixedly connected to the outer wall of the transmission pipe 4. An annular airbag 502 is fixedly connected to the outer wall of the transmission pipe 4. The limiting ring 501 is used to limit the position of the annular airbag 502. Multiple connecting rods 503 are fixedly connected to the outer wall of the transmission pipe 4. The connecting rods 503 fix an annular plate 504 to the transmission pipe 4. An annular plate 504 is fixedly connected to one end of each of the multiple connecting rods 503. An ultraviolet plate 505 is fixedly connected to the inner wall of the annular plate 504. The ultraviolet plate 505 is used to sterilize the overflowing bacterial-containing gas. A monitoring component 506 is provided on the outer wall of the annular airbag 502. Component 506 includes a clamp 5062, the inner wall of which is fixedly connected to the outer wall of the transmission pipe 4. A pressure sensor 5061 is fixedly connected to the top of the clamp 5062 for detecting the pressure on the transmission pipe 4. An inflation assembly 507 is provided on the outer wall of the base frame 1. The inflation assembly 507 includes a gas tank 5073 for storing gas. The outer wall of the gas tank 5073 is fixedly connected to the outer wall of the base frame 1. An inflation pipe 5072 is connected to the top of the gas tank 5073. The inflation pipe 5072 is the gas transmission path. A solenoid valve 5071 is fixedly connected to the outer wall of the inflation pipe 5072 for controlling whether the gas is transmitted.

[0032] The inner wall of the limiting ring 501 is fixedly connected to the outer wall of the transmission pipe 4. The outer wall of the transmission pipe 4 is equipped with an annular airbag 502. The limiting ring 501 limits the annular airbag 502. The outer wall of the transmission pipe 4 is also connected to multiple connecting rods 503. The connecting rods 503 fix the ring plate 504 and the transmission pipe 4 to each other. The outer ends of the multiple connecting rods 503 are all connected to the ring plate 504. The inner wall of the ring plate 504 is equipped with an ultraviolet plate 505 for sterilizing the overflowing bacteria-containing gas. The gas tank 5073 is fixed to the outer wall of the base frame 1 and is used to store gas. The top of the gas tank 5073 is connected to an inflation pipe 5072. The inflation pipe 5072 serves as a gas transmission channel. Its outer wall is equipped with a solenoid valve 5071. The solenoid valve 5071 controls the passage of gas. When the gas reaches the discharge requirement, the solenoid valve 5071 will automatically detect and close the valve.

[0033] Please see the appendix Figure 3 -Appendix Figure 8This invention provides a microsphere emulsification device for use in a sterile isolator. The integrated mechanism 6 includes a clean water tank 601 for storing clean water. The outer wall of the clean water tank 601 is fixedly connected to the outer wall of the base frame 1. A U-shaped pipe 602 is connected to the top of the clean water tank 601, which connects the clean water tank 601, the acid tank 604, and the alkaline tank 605 together. A check valve 603 is fixedly connected to the outer wall of the U-shaped pipe 602 to control the outflow of liquid from each tank. The bottom end of the U-shaped pipe 602 is connected to the acid tank 604, and the outer wall of the U-shaped pipe 602 is connected to the alkaline tank 605. The acid tank 604 and the alkaline tank 605 are used to adjust the emulsification tank 2. The pH value inside the device adaptively adjusts the cleaning solution. A generating assembly 606 is fixedly connected to the outer wall of the base frame 1. A ring pipe 610 is fixedly connected to the bottom of the sealing cap 3 for fixing the spray gun 611 and providing a flow channel for cleaning water. Multiple spray guns 611 are fixedly connected to the outer wall of the ring pipe 610 for rinsing and cleaning the inner wall of the emulsified functional layer 10. The generating assembly 606 includes a steam generator 6061, which heats water to a vaporized state to generate steam that meets temperature, pressure, and purity requirements. The outer wall of the steam generator 6061 is fixedly connected to the outer wall of the base frame 1. A guide pipe 6062 is connected to the top of the steam generator 6061, and the guide pipe 6062 carries water... The water is transported to the steam generator 6061 via a high-temperature resistant gas pump 6064 connected to the top of the base frame 1. The high-temperature resistant gas pump 6064, through its own action, transports water from the storage tank 11 to the steam generator 6061. The outer wall of the high-temperature resistant gas pump 6064 is connected to a steam inlet pipe 6063, which is one end where steam is drawn into the high-temperature resistant gas pump 6064. A steam outlet pipe 6065 is one end where steam is discharged from the high-temperature resistant gas pump 6064. The top of the high-temperature resistant gas pump 6064 is connected to the steam outlet pipe 6065. A transmission assembly 607 is fixedly connected to the outer wall of the base frame 1. The transmission assembly 607 includes a water pump 6072, the outer wall of which is fixedly connected to the outer wall of the base frame 1. The outer wall of tank 6072 is connected to a water outlet pipe 6071. A filter assembly 608 is installed on the outer wall of the emulsification tank 2. The filter assembly 608 includes a filter box 6082 for filtering wastewater generated after cleaning the emulsification tank 2. The outer wall of the filter box 6082 is fixedly connected to the outer wall of the base frame 1. An inlet pipe 6081 is fixedly connected to the outer wall of the filter box 6082, serving as a channel for wastewater to enter the filter box 6082. An outlet pipe 6083 is fixedly connected to the outer wall of the filter box 6082, providing a discharge channel for the purified liquid in the filter box 6082. A flushing assembly 609 is installed on the outer wall of the base frame 1, including a water pump 6091.It is used to clean the outer wall of the emulsification functional layer 10 of the emulsification tank 2 with water. The outer wall of the second water pump 6091 is fixedly connected to the outer wall of the base frame 1. The top of the second water pump 6091 is connected to a first connecting pipe 6092, and the outer wall of the second water pump 6091 is connected to a second connecting pipe 6093. The first connecting pipe 6092 and the second connecting pipe 6093 are located at two ports of the second water pump 6091, respectively, and are responsible for the inlet and outlet of water.

[0034] The integrated mechanism 6 is used to store the water needed for cleaning. The outer wall of the clean water tank 601 is fixedly connected to the outer wall of the base frame 1. A U-shaped pipe 602 is connected to the top of the clean water tank 601, connecting the clean water tank 601, the acid tank 604, and the alkaline tank 605. A check valve 603 is installed on the outer wall of the U-shaped pipe 602, which controls or cuts off the flow of liquid in each tank. The bottom end of the U-shaped pipe 602 is connected to the acid tank 604, and the other side of its outer wall is connected to the alkaline tank 605. The purpose of the acid tank 604 and the alkaline tank 605 is to determine the pH value detected inside the emulsification tank 2. The acidity and alkalinity of the cleaning solution are automatically adjusted to maintain a neutralization effect. A key component of the generating assembly 606 is the steam generator 6061. The function of the steam generator 6061 is to heat water to vaporize it, generating steam that meets the set temperature, pressure, and purity requirements. The outer wall of the steam generator 6061 is fixed to the base frame 1, and its top is connected to a guide pipe 6062, which serves as a channel for water to flow to the steam generator 6061. A high-temperature resistant air pump 6064 is mounted on the top of the base frame 1. The high-temperature resistant air pump 6064 uses its own power to transport water from the storage tank 11 to the steam generator 6061. Among them, the outer wall of the high-temperature resistant steam pump 6064 is connected to the steam inlet pipe 6063, which is the inlet end where steam is drawn into the high-temperature resistant steam pump 6064, while the steam outlet pipe 6065 is the outlet end where steam is discharged from the high-temperature resistant steam pump 6064. The steam outlet pipe 6065 is connected to the top of the high-temperature resistant steam pump 6064. The outer wall of the water pump 6072 is fixed to the base frame 1, and its outer wall is connected to the water outlet pipe 6071 for liquid transportation. The purpose of the filter box 6082 is to filter the wastewater generated after cleaning the emulsification tank 2. The outer wall of the filter box 6082 is fixed to the base frame 1, and its outer wall is connected to the inlet pipe 6081. The flow pipe 6081 serves as a channel for sewage to flow into the filter box 6082. An outlet pipe 6083 is fixed on the outer wall of the other side of the filter box 6082. The function of the outlet pipe 6083 is to provide a discharge path for the liquid purified by the filter box 6082. The second water pump 6091 drives the water flow to clean the outer wall of the emulsification functional layer 10 inside the emulsification tank 2. The outer wall of the second water pump 6091 is fixedly connected to the base frame 1. Its top is connected to the first connecting pipe 6092, and its outer wall is connected to the second connecting pipe 6093. The first connecting pipe 6092 and the second connecting pipe 6093 are located at the two ports of the second water pump 6091, respectively, and are responsible for the intake and discharge of water.

[0035] Please see the appendix Figure 1 -Appendix Figure 3This invention provides a microsphere emulsification device for use in a sterile isolator. The bottom of the sealing cover 3 is fixedly connected to a support layer 8, which is used to ensure the stability of the membrane structure during emulsification and backflushing. The outer wall of the sealing cover 3 is connected to a U-shaped tube 9, which is used to transmit cleaning liquid for cleaning the inside of the emulsification functional layer 10. The top of the base frame 1 is fixed with a liquid storage tank 11 for storing water used to generate steam.

[0036] The support layer 8 is located at the bottom of the sealing cap 3 and also on the outside of the emulsifying functional layer 10. The pore size of the support layer 8 is slightly larger than that of the mesh in the emulsifying functional layer 10. The U-shaped tube 9 is fixed to the top of the sealing cap 3 and is used to connect the ring tube 610. The liquid storage tank 11 serves as a separate water storage tank, providing a prerequisite for the generation of steam.

[0037] Working principle: The entire device consists of multiple tanks and is equipped with a PLC controller to realize the standardized aseptic operation of the emulsification process. When the two ends of the transfer pipe 4 are connected, the annular air bladder 502 is inflated under the control of the solenoid valve 5071 and tightly fits the interface surface. Since the pressure sensor 5061 is set on the outside of the annular air bladder 502, the pressure achieves an adaptive adjustment effect. By monitoring the sealing pressure in real time and linking it with the internal pressure of the transfer pipe 4, when the internal pressure of the transfer pipe 4 fluctuates due to operation, the device will automatically adjust the inflation volume of the annular air bladder 502 through the solenoid valve 5071 to keep its sealing pressure within a relatively stable range. While achieving physical isolation, the ultraviolet plate 505 located in the annular plate 504 outside the annular air bladder 502 works in a sealed state to irradiate the gap area formed by the physical seal and inactivate any microorganisms that may leak or exist. The entire adaptive mechanism 5 realizes the aseptic sealing and adaptive pressure adjustment of the transfer pipe 4.

[0038] During the emulsification process, the device automatically switches to self-cleaning mode under the intervention of the PLC controller at regular intervals. The spray gun 611 integrated at the bottom of the sealing cover 3 is opened, allowing the cleaning solution to enter the spray gun 611 from the clean water tank 601 through the U-shaped tube 9, removing the initially accumulated residue and maintaining the normal operation of the internal structure. When the transmembrane differential pressure sensor detects increased contamination or the microbial sensor alarms, the device intervenes again and switches to deep cleaning mode. The integrated cleaning and sterilization module is then activated. The PLC controller controls the switching of the three check valves 603 according to the preset program, pumping the heated alkaline and acidic cleaning solutions and sterile water into the cleaning channel and the entire emulsification chamber of the emulsification tank 2 in sequence for closed-loop circulation to achieve chemical cleaning. Subsequently, the device automatically enters the sterilization process, generating high-pressure steam through the steam generator 6061 and passing it through to sterilize all contact surfaces, including the membrane pores, to ensure a sterile state. All cleaning and sterilization waste liquid is discharged after being treated by the filter box 6082 on one side of the emulsification tank 2 to avoid the risk of secondary contamination.

[0039] The coating structure 7 first bonds to the membrane substrate with a transition bonding layer 701, retaining the active sites 703 on the upper layer. The modified layer 702 is arranged in a brush-like manner to form a water film to reduce material adhesion. The coating micropores 704 are adapted to the cleaning fluid channels. During backwashing, the cleaning fluid permeates through the micropores 704, and together with the brush-like arrangement of the modified layer 702, removes residues from the membrane surface, reduces pollutant deposits, and improves backwashing efficiency, ensuring the sterility and emulsification effect of the membrane module.

[0040] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A microsphere emulsification device for use in a sterile isolator, comprising a base frame (1), characterized in that, The top of the base frame (1) is fixedly connected to an emulsifying tank (2), the top of the emulsifying tank (2) is fixedly connected to a sealing cap (3), the right side of the outer wall of the emulsifying tank (2) is connected to a transfer pipe (4), the bottom of the sealing cap (3) is fixedly connected to an emulsifying functional layer (10), the outer wall of the transfer pipe (4) is provided with an adaptive mechanism (5), the adaptive mechanism (5) is used to adaptively adjust the pressure at the connection of the transfer pipe (4), the outer wall of the base frame (1) is provided with an integration mechanism (6), the integration mechanism (6) is used to perform liquid cleaning and sterilization operations, the outer wall of the sealing cap (3) is provided with a coating mechanism (7), the coating mechanism (7) is used to reduce the adhesion between the material and the membrane surface; The adaptive mechanism (5) includes a limiting ring (501), the inner wall of which is fixedly connected to the outer wall of the transmission pipe (4), an annular airbag (502) is fixedly connected to the outer wall of the transmission pipe (4), a plurality of connecting rods (503) are fixedly connected to the outer wall of the transmission pipe (4), an annular plate (504) is fixedly connected to the other side of the connecting rod (503), an ultraviolet plate (505) is fixedly connected to the inner wall of the annular plate (504), a monitoring component (506) is provided on the outer wall of the annular airbag (502), and an inflation component (507) is provided on the outer wall of the base frame (1).

2. The microsphere emulsification device for use in a sterile isolator according to claim 1, characterized in that, The integrated mechanism (6) includes a water tank (601), the bottom of which is fixedly connected to the top of the base frame (1). The top of the water tank (601) is connected to a mountain-shaped pipe (602). A stop valve (603) is fixedly connected to the outer wall of the mountain-shaped pipe (602). An acid tank (604) is connected to the bottom of the mountain-shaped pipe (602). An alkaline tank (605) is connected to the outer wall of the mountain-shaped pipe (602). A ring pipe (610) is fixedly connected to the bottom of the sealing cap (3). Multiple spray guns (611) are fixedly connected to the outer wall of the ring pipe (610). A generating component (606) is fixedly connected to the outer wall of the base frame (1). A transmission component (607) is fixedly connected to the outer wall of the base frame (1). A filter component (608) is provided on the outer wall of the emulsification tank (2). A flushing component (609) is provided on the outer wall of the base frame (1).

3. The microsphere emulsification device for use in a sterile isolator according to claim 1, characterized in that, The coating structure (7) includes a transition bonding layer (701), the inner wall of which is fixedly connected to the outer wall of the emulsifying functional layer (10), a modified layer (702) is fixedly connected to the inner wall of the transition bonding layer (701), and an active site (703) is fixedly connected to the side of the modified layer (702) near the transition bonding layer (701), and the outer wall of the active site (703) is provided with a plurality of micropores (704).

4. A microsphere emulsification device for use in a sterile isolator according to claim 1, characterized in that, The monitoring component (506) includes a hoop (5062), the inner wall of which is fixedly connected to the outer periphery of the transmission pipe (4), and a pressure sensor (5061) is fixedly connected to the top of the hoop (5062).

5. A microsphere emulsification device for use in a sterile isolator according to claim 1, characterized in that, The inflation assembly (507) includes an air tank (5073), the bottom of which is fixedly connected to the top of the base frame (1), and the top of which is connected to an inflation pipe (5072). A solenoid valve (5071) is fixedly connected to the outer wall of the inflation pipe (5072).

6. A microsphere emulsification device for use in a sterile isolator according to claim 2, characterized in that, The generating assembly (606) includes a steam generator (6061), the bottom of which is fixedly connected to the top of the base frame (1). The top of the steam generator (6061) is connected to a guide pipe (6062), the top of the base frame (1) is connected to a high-temperature resistant gas pump (6064), the outer wall of the high-temperature resistant gas pump (6064) is connected to a steam inlet pipe (6063), and the top of the high-temperature resistant gas pump (6064) is connected to a steam outlet pipe (6065).

7. A microsphere emulsification device for use in a sterile isolator according to claim 2, characterized in that, The transmission component (607) includes a water pump (6072), the bottom of which is fixedly connected to the top of the base frame (1), and the output end of the water pump (6072) is fixedly connected to a water outlet pipe (6071).

8. A microsphere emulsification device for use in a sterile isolator according to claim 2, characterized in that, The filter assembly (608) includes a filter box (6082), the bottom of which is fixedly connected to the top of the base frame (1), an inlet pipe (6081) is fixedly connected to the outer wall of the filter box (6082), an outlet pipe (6083) is fixedly connected to the outer wall of the filter box (6082), and an emulsifying tank (2) is fixedly connected to the outer wall of the inlet pipe (6081).

9. A microsphere emulsification device for use in a sterile isolator according to claim 2, characterized in that, The flushing assembly (609) includes a second water pump (6091), the bottom of which is fixedly connected to the top of the base frame (1). The top of the second water pump (6091) is connected to a first connecting pipe (6092), the outer wall of the second water pump (6091) is connected to a second connecting pipe (6093), and the outer wall of the mountain-shaped pipe (601) is connected to a second connecting pipe (6093).

10. A microsphere emulsification device for use in a sterile isolator according to claim 1, characterized in that, The bottom of the sealing cover (3) is fixedly connected to a support layer (8), the outer wall of the sealing cover (3) is connected to a U-shaped tube (9), and the top of the base frame (1) is fixed with a liquid storage tank (11).

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