Weeding composition and application thereof
The combination of flupyridine, flupyridine ester and clopyralid has solved the problem of weed resistance, achieved efficient control of broadleaf weeds in wheat fields, expanded the spectrum of weed control and maintained environmental friendliness.
Patent Information
- Application Number
- CN202411176073.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-26
- Publication Date
- 2026-03-03
AI Technical Summary
Long-term use of single chemical herbicides has led to the development of herbicide resistance in weeds. It is still unclear whether existing herbicides can be combined or mixed to achieve synergistic effects.
A composition of flupyridine, flupyridine ester and clopyralid, in a mass ratio ranging from (30-120):(4-8):(45-180), is used to prepare dispersible oil suspensions, suspensions, water emulsions, wettable powders and other formulations for controlling broadleaf weeds such as speedwell, chickweed, sedge, shepherd's purse and shepherd's purse in wheat fields.
It significantly improves the control effect of herbicide-resistant weeds, expands the weed control spectrum, extends the application cycle, and is environmentally friendly and safe for subsequent crops, with a control effect of over 95%.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of herbicide technology, and more specifically to a herbicide composition and its application. Background Technology
[0002] Wheat is the most widely distributed grain crop in the world, with the largest sown area among all grain crops, making it one of the most important food sources. my country's main wheat-producing areas are Shandong, Henan, Hebei, Anhui, and Jiangsu provinces. Wheat production is of great significance to my country's economic development and national welfare. Reports indicate that there are over 200 species of weeds in wheat fields in my country, affecting more than 30% of the wheat planting area and causing losses of approximately 15% of total wheat production. Therefore, weed control in wheat fields has become a crucial aspect of wheat production.
[0003] Chemical weeding is currently the most economical and effective means of controlling weeds in farmland. However, long-term, continuous, and high-dose use of relatively limited chemical herbicides of a single variety or with a single mode of action has led to problems such as the development of herbicide resistance and resistance in weeds. Therefore, the rational compounding or mixing of herbicide compounds has the advantages of broadening the weed spectrum, improving control efficacy, and delaying the occurrence and development of herbicide resistance in weeds. It is one of the most effective methods to solve the above problems. However, whether compounding and mixing can achieve synergistic effects is an issue that needs attention. Summary of the Invention
[0004] The purpose of this invention is to provide a weed control composition and its application.
[0005] To achieve the above objectives, the present invention adopts the following technical solution:
[0006] A herbicidal composition comprising at least two components selected from flupyridine, flupyridine ester, and clopyralid.
[0007] The composition is flupyridine and flupyridine ester, wherein the mass ratio of flupyridine to flupyridine ester is (30-120):(4-8).
[0008] The composition is flupyridine and flupyridine ester, wherein the mass ratio of flupyridine to flupyridine ester is (40-80):(6-10).
[0009] The composition comprises flupyridine, flupyridine ester and clopyroxyacetic acid; wherein the mass ratio of flupyridine, flupyridine ester and clopyroxyacetic acid is (30-120):(4-8):(45-180).
[0010] The composition comprises flupyridine, flupyridine ester and clopyroxyacetic acid; wherein the mass ratio of flupyridine, flupyridine ester and clopyroxyacetic acid is (40-80):(3-6):(80-100).
[0011] Application of a herbicidal composition in controlling weeds in crops.
[0012] The crop in question is wheat.
[0013] The weeds were selected from broadleaf weeds.
[0014] The weeds are selected from at least one of Veronica persica, Stellaria media, Sophora flavescens, Artemisia annua, and Capsella bursa-pastoris.
[0015] A pesticide herbicide, comprising the aforementioned composition and excipients, wherein the composition comprises 1-99.99% by weight based on the total weight of the herbicide.
[0016] According to practical application needs, the pesticide herbicide of the present invention can be prepared into one of the following formulations: dispersible oil suspension, suspension, water emulsion, wettable powder, water dispersible granules, etc.
[0017] The auxiliary components required for formulating pesticide formulations may include solvents (ethoxylated castor oil, water, alcohols, ketones, solvent oils, methyl oleate), penetrants (ethylene oxide condensates, fatty alcohol ethylene oxide condensates, sorbitol esters, glycerol), stabilizers (sulfated hexadecanoic acid and sulfated fatty alcohol glycol ethers, alkyl aryl polyether alcohols, alkylphenol formaldehyde resin polyoxyethylene ethers, polyoxyethylene alkyl ethers, xanthan gum, magnesium aluminum silicate, sodium benzoate, organobentonite, ammonium sulfate), emulsifiers (sulfonate succinates, taurine derivatives and phosphate esters of alcohols or polyhydroxyethylated phenolic phosphate esters, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, lauryl glycol ether acetals, castor oil polyoxyethylene ethers, tristyrene-phenylphenol polyoxyethylene ether phosphate esters, calcium dodecylbenzenesulfonate, polyoxyethylene dehydrated sorbitan monooleate, sodium dodecyl sulfate), and wetting agents (sulfonate succinates, alkyl sulfonate salts, alkyl...). Aryl sulfonates, octylphenol, nonylphenol), dispersants (polyacrylates, lignin sulfonates, phenol sulfonic acid or naphthalene sulfonates, polymers of ethylene oxide with aliphatic alcohols or with aliphatic acids or with aliphatic amines and substituted phenols, lignin sulfite waste liquid, condensates of naphthalene or naphthalene sulfonic acid with phenol and formaldehyde, sodium lignin sulfonate, naphthalene sulfonate, calcium lignin sulfonate, sodium naphthalene sulfonate formaldehyde condensates), thickeners, pH adjusters, defoamers (polyoxyethylene octyl anisole, ethoxylated...) One or a mixture of several of the following: isooctyl ether, alkylphenyl polyethylene glycol ether, tributylphenyl polyethylene glycol ether, tristearate phenyl polyethylene glycol ether, polyvinyl alcohol, ethoxylated polyoxypropylene, block polyether), antifreeze, carrier and filler (silica, kaolin, protein, denatured protein, polysaccharide, hydrophobically modified starch, polycarboxylate, polyoxyalkylene oxide, polyethyleneamine, polyvinylpyrrolidone and copolymers, clay, natural or synthetic silicate, silica, resin).
[0018] The herbicidal composition or corresponding formulation provided by this invention can significantly improve the control of herbicide-resistant weeds in wheat fields.
[0019] The herbicidal composition or herbicide of the present invention also has at least the following advantages:
[0020] (1) The herbicidal composition provided by the present invention is environmentally friendly and safe for subsequent crops.
[0021] (2) The herbicidal composition provided by the present invention can effectively kill weeds and reduce the harm of weeds to crops.
[0022] (3) Compared with the prior art, the herbicidal composition provided by the present invention can control broadleaf weeds such as resistant speedwell, shepherd's purse, and shepherd's purse. Detailed Implementation
[0023] The present invention will be further described below with reference to specific embodiments, but the present invention should not be construed as being limited to these embodiments.
[0024] The composition of this invention, when combined within a certain ratio range, exhibits excellent control effects against weeds in wheat fields. The control efficacy and activity levels it demonstrates exceed the sum of the individual components, resulting in an unexpected synergistic effect. This overcomes the limitations of the two herbicides mentioned above in terms of weed control spectrum, efficacy, and safety, achieving the goals of expanding the weed control spectrum, improving efficacy, and enhancing safety. It can meet the current agricultural demand for herbicides.
[0025] All substances used in the following examples are commercially available. The components of the composition were mixed in two or three proportions according to the proportions described above to obtain different compositions for use as pharmaceuticals, which were then tested for herbicidal effects.
[0026] Example 1: Indoor Experiment
[0027] 1) Test conditions
[0028] The tested weed was *Veronica persica*. The experimental materials were cultivated in a heated glass greenhouse at a temperature of 15-25℃ under natural light. A measured quantity of *Veronica persica* seeds was sown in 9cm diameter plastic pots, covered with 1-2mm of soil, and placed in an enamel dish filled with water. The water was allowed to gradually seep in until it reached the soil surface, after which the pots were transferred to an artificial climate chamber for later use. Different mixtures of pesticides were sprayed according to the dosages listed in Table 1. Except for 1-2 days after spraying, watering was not permitted, and regular bottom irrigation was used to maintain soil moisture.
[0029] Herbicidal activity test method: Foliar spraying (NY / T 1155.4-2006) was used. A measured amount of soil was filled to 3 / 4 of the height of a pot (11 cm high, 9 cm in diameter). 15–20 seeds of the target weedy rice were evenly sown on the soil surface, covered with about 1 cm of fine soil, and then placed in a greenhouse (temperature 22–28℃, humidity 97%, the same below) for cultivation. When the weedy rice reached the 3–5 leaf stage, foliar spraying was performed, with 1 mL of herbicide solution sprayed per pot. Each treatment was replicated 4 times. After treatment, the test materials were placed in a greenhouse for cultivation, and the growth of the target weedy rice was observed regularly.
[0030] Investigation Methods: After 30 days of experimental treatment, the symptoms of damage and growth inhibition of the target plants were visually observed, and the fresh weight of the aboveground parts was measured. The fresh weight inhibition rate (%) was calculated. Fresh weight inhibition rate (%) = (Control fresh weight - Treatment fresh weight) / Control fresh weight × 100
[0031] Evaluation method for combined action of herbicides: The Gowing method is used to evaluate the combined action of herbicides (NY / T1155.7-2006).
[0032] The formula is: E0=X+Y×(100-X) / 100, where X and Y are the measured control efficacy values (%) of the two single agents, respectively; E0 is the theoretical control efficacy of weeds when flupyridine and flupyridine are used in combination; E is the actual control efficacy of weeds when flupyridine and flupyridine are used in combination. The results are shown in Table 1.
[0033] Evaluation criteria: When E-E0 > 10%, it indicates a synergistic effect; when E-E0 is between ±10%, it indicates an additive effect; and when E-E0 < -10%, it indicates an antagonistic effect.
[0034] Table 1: Indoor control efficacy of flupyridine and flupyridine ester combined against speedwell.
[0035]
[0036] As shown in Table 1, the combination of flupyridine and flupyridine ester has a synergistic effect on Veronica persica.
[0037] Example 2 Indoor Experiment
[0038] 1) Test conditions
[0039] The tested weeds were Veronica persica, Chickweed, Smilax china, Echinochloa crus-galli, and Capsella bursa-pastoris. The experimental materials were cultivated in a heated glass greenhouse at 15-25℃ under natural light. Quantities of Veronica persica, Chickweed, Smilax china, Echinochloa crus-galli, and Capsella bursa-pastoris seeds were sown in 9cm diameter plastic pots, covered with 1-2mm of soil, and placed in enamel dishes filled with water. The water was allowed to gradually seep in until it reached the soil surface, after which the pots were transferred to an artificial climate chamber for later use. Different mixtures of pesticides were sprayed according to the dosages listed in Table 2. Except for 1-2 days after spraying, watering was not permitted, and regular bottom irrigation was used to maintain soil moisture.
[0040] Herbicidal activity test method: Foliar spraying (NY / T 1155.4-2006) was used. A measured amount of soil was filled to 3 / 4 of the height of a pot (11 cm high, 9 cm in diameter). 15–20 seeds of the target weedy rice were evenly sown on the soil surface, covered with about 1 cm of fine soil, and then placed in a greenhouse (temperature 22–28℃, humidity 97%, the same below) for cultivation. When the weedy rice reached the 3–5 leaf stage, foliar spraying was performed, with 1 mL of herbicide solution sprayed per pot. Each treatment was replicated 4 times. After treatment, the test materials were placed in a greenhouse for cultivation, and the growth of the target weedy rice was observed regularly.
[0041] Methods: The fresh weight of the aboveground parts was measured 30 days after the trial, the weed survival rate E was calculated, and the Colby method was used to evaluate the type of action of the mixed agents and to further explore the rationality of the ratio.
[0042] E = Fresh weight of weeds in treatment area × 100 / Fresh weight of weeds in control area
[0043] Evaluation method for ternary synergistic effects: The Colby method (NY / T1155.7-2006) is used to evaluate the synergistic effects of herbicides. The formula is: E0 = XYZ / 100 2 In the formula,
[0044] X — Weed survival rate when the dosage of herbicide A is P;
[0045] Y – Weed survival rate when the dosage of herbicide B is Q;
[0046] Z – Weed survival rate when the dosage of herbicide C is W;
[0047] E0 – The theoretical weed survival rate of herbicide (A+B+C) at a dosage of (P+Q+W);
[0048] Evaluation criteria: E0-E > 10% indicates a synergistic effect; E0-E < -10% indicates an antagonistic effect; E0-E values between ±10% indicate an additive effect. The results are shown in Table 2.
[0049] Table 2. Measured and theoretical survival rates of weeds when mixed with flupyridine, flupyridine ester, and clopyralid.
[0050]
[0051]
[0052] As shown in Table 2, flupyridine, flupyridine ester, and clopyralid have significant control effects against the combined toxicity of Veronica persica, Stellaria media, Smilax china, Desmodium styracifolium, and Capsella bursa-pastoris.
[0053] Example 3: Field efficacy trial:
[0054] The experimental crop was wheat, which was in the 3-4 leaf stage, growing well and with robust plants, free from other diseases and pests, while weeds were in the 3-4 leaf stage.
[0055] Experimental Treatments: Field validation was conducted using the provided herbicide composition in Shangqiu and Xiayi, Henan Province. The experimental plots were loam soil with an organic matter content of 1.8% and a pH of 7.15. 50 kg of compound fertilizer was applied at wheat sowing, and 10 kg of urea was applied at the jointing stage. The herbicide was then applied when the soil moisture (RH%) reached approximately 50% (as described in Table 3). A backpack sprayer was used, with each treatment sprayed evenly at a rate of 30 liters per acre. Areas with severe weed infestation were selected, and the herbicides were applied in 20m² areas. 2 Each treatment was repeated three times in one plot. After 42 days, the treated and control areas were observed, the number of weeds was counted, and the plant control efficacy was calculated in the treated areas. The plant control efficacy (%) was calculated.
[0056] Control efficacy (%) = (Number of control weeds - Number of treatment weeds) / Number of control weeds × 100%
[0057] Test reagents: 20% flupyridine suspension, 288g / clopyroxyacetic acid isooctyl ester suspension, 1% flupyridine ester suspension
[0058] Target pest: Veronica
[0059] Table 3 Field efficacy of flupyridine and flupyridine in wheat
[0060]
[0061] As shown in Table 3, the combination of flupyridine and flupyridine significantly enhances the efficacy of Veronica persica.
[0062] This invention expands the weed control spectrum and extends the application cycle through compound formulation. It not only has a significant weed control effect, but is also environmentally friendly and has no impact on wheat and its subsequent crops.
[0063] Example 4: Field efficacy trial:
[0064] The experimental crop was wheat, which was in the 3-4 leaf stage, growing well and with robust plants, free from other diseases and pests, while weeds were in the 3-4 leaf stage.
[0065] Experimental Treatments: Field validation was conducted using the provided herbicide composition in Shangqiu and Xiayi, Henan Province. The experimental plots were loam soil with an organic matter content of 1.8% and a pH of 7.15. 50 kg of compound fertilizer was applied at wheat sowing, and 10 kg of urea was applied at the jointing stage. The herbicide was then applied when the soil moisture (RH%) reached approximately 50% (application rates are detailed in Table 4). A backpack sprayer was used, with each treatment applied at a uniform spray rate of 30 liters per acre. Fields with severe weed infestation were selected, and the herbicides were applied in 20m² areas. 2 Each treatment was repeated three times in one plot. After 42 days, the treated and control areas were observed, the number of weeds was counted, and the plant control efficacy was calculated in the treated areas. The plant control efficacy (%) was calculated.
[0066] Control efficacy (%) = (Number of control weeds - Number of treatment weeds) / Number of control weeds × 100%
[0067] Test reagents: 20% flupyridine suspension, 288g / clopyroxyacetic acid isooctyl ester suspension, 1% flupyridine ester suspension
[0068] Target plants for control: Veronica persica, Chickweed, Sow thistle, and shepherd's purse.
[0069] Table 4. Field efficacy of flupyridine, flupyridine ester, and clopyralid in wheat.
[0070]
[0071]
[0072] Table 4 shows that flupyridine has a good control effect on Veronica persica, but a slightly poor control effect on Galium aparine and Capsella bursa-pastoris; flupyridine ester and clopyralid have a very good control effect on Galium aparine, but a moderate control effect on other weeds; the combination of flupyridine ester, flupyridine ester and clopyralid is highly effective against all of the above weeds.
[0073] Example 5 Preparation of a suspension of flupyridine (4g), clopyralid (8g), and flupyridine ester (0.5g)
[0074] Suspension formulations were prepared from 96% flupyridine technical grade, 95% clopyroxyacetic acid technical grade, and 93% flupyridine technical grade. Quantities of flupyridine, clopyroxyacetic acid, and flupyridine technical grade were weighed separately using an electronic balance. First, a special emulsifier was added to dissolve them, then twice the amount of N,N-dimethylformamide was added until completely dissolved. The solution was diluted with 0.1% Tween-80 aqueous solution to prepare a 1% aqueous suspension for later use. A suspension of flupyridine (4 g), clopyroxyacetic acid (8 g), and flupyridine (0.5 g) was prepared.
[0075] This invention significantly enhances the efficacy of combined herbicides against Veronica persica, Chickweed, Smilax china, Desmodium styracifolium, and Capsella bursa-pastoris, achieving control efficacy of over 95%. It also broadens the weed control spectrum, achieving better control effects, and no phytotoxicity was observed in wheat. This invention is of great significance for integrated pest management in the field.
[0076] Although the present invention has been described in detail by way of preferred embodiments, the present invention is not limited thereto. Various equivalent modifications or substitutions can be made to the embodiments of the present invention by those skilled in the art without departing from the spirit and essence of the invention, and such modifications or substitutions should all be within the scope of the present invention. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should also be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be determined by the scope of the claims.
Claims
1. A herbicidal composition, characterized in that: The composition is a combination of at least two components selected from flupyridine, flupyridine ester and clopyroxyacetic acid.
2. The herbicidal composition according to claim 1, characterized in that: The composition is flupyridine and flupyridine ester, wherein the mass ratio of flupyridine to flupyridine ester is (30-120):(4-8).
3. The herbicidal composition according to claim 1, characterized in that: The composition comprises flupyridine, flupyridine ester and clopyroxyacetic acid; wherein the mass ratio of flupyridine, flupyridine ester and clopyroxyacetic acid is (30-120):(4-8):(45-180).
4. The use of the herbicidal composition of claim 1 in controlling weeds in crops.
5. The application according to claim 4, characterized in that: The crop in question is wheat.
6. The application according to claim 4, characterized in that: The weeds were selected from broadleaf weeds.
7. The application according to claim 6, characterized in that: The weeds are selected from at least one of Veronica persica, Stellaria media, Sophora flavescens, Artemisia annua, and Capsella bursa-pastoris.
8. A pesticide herbicide, characterized in that, The herbicide comprises the composition and excipients described in claim 1, wherein the content of the composition is 1-99.99% by weight, based on the total weight of the herbicide.