Oral composition

Abstract

Provided is an oral composition which has excellent fluorine ion retention properties and is capable of suppressing the formation of a dope. The oral composition contains (A) sodium fluoride, (B) a water-soluble calcium salt, (C) at least one selected from the group consisting of condensed phosphoric acid and salts thereof, and (D) a zinc ion source.

Description

Technical Field

[0001] This invention relates to oral compositions. Background Technology

[0002] Fluorides such as sodium fluoride are widely used as pharmaceutical ingredients in oral care products such as dental cleaning agents because of their caries-preventing effects. For fluorides to be effective, it is desirable for fluoride ions to remain on the oral mucosa and tooth surfaces for an extended period, ideally leaving a significant amount of fluoride ions in the mouth even after rinsing with water following application.

[0003] Patent document 1 proposes a method to enable the coexistence of calcium ions, fluoride ions, and phosphate ions as a way to improve the retention of fluoride ions.

[0004] In addition, Patent Document 2 proposes a liquid oral composition containing sodium fluoride (A), calcium glycerophosphate (B), condensed phosphate or its salt (C), and a cationic bactericide (D), which has both excellent fluoride retention and sustained bactericidal effect against cariogenic bacteria, and is effective in preventing or inhibiting tooth decay.

[0005] Existing technical documents Patent documents Patent Document 1: Japanese Patent Application Publication No. 2009-137863 Patent Document 2: Japanese Patent Application Publication No. 2017-66036 Summary of the Invention

[0006] The technical problem that the invention aims to solve However, as the inventors know, when the above-mentioned components (A), (B) and (C) form a complex, although the retention of fluoride ions is improved, a viscous substance may be generated. When the viscous substance appears on the cap or cap fitting of the container containing the oral composition, there is a problem that the cap sometimes cannot be opened or closed smoothly.

[0007] The purpose of this invention is to provide an oral composition that exhibits excellent fluoride ion retention and is able to inhibit the formation of viscous substances.

[0008] Technical solutions for solving technical problems The present invention has the following aspects.

[0009] [1] An oral composition comprising: (A) Ingredients: Sodium fluoride, (B) Ingredients: Water-soluble calcium salts, (C) Components: at least one selected from the group consisting of condensed phosphates and their salts, and (D) Component: Zinc ion source.

[0010] [2] The oral composition according to [1], wherein the (B) component comprises one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate and calcium pantothenate.

[0011] [3] The oral composition according to [1] or [2], wherein the (C) component comprises one or more selected from the group consisting of sodium tripolyphosphate, pyrophosphate and alkali metal pyrophosphate.

[0012] [4] The oral composition according to any one of [1] to [3], wherein the (D) component comprises one or more selected from the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate and zinc laurate.

[0013] [5] The oral composition according to any one of [1] to [4], wherein the (B) / (D) ratio, which represents the molar ratio of component (B) to component (D), is 0.01 to 300.

[0014] Invention Effects According to the present invention, an oral composition with excellent fluoride ion retention and the ability to suppress the formation of viscous substances can be obtained. Detailed Implementation

[0015] In this specification, "oral composition" refers to a composition primarily intended for use in the oral cavity.

[0016] In this instruction manual, "water solubility" means that the solubility in water at 20°C is 1g / 100g or more.

[0017] In this specification, the "~" symbol, which indicates a range of values, means that the values ​​listed before and after it are included as the lower and upper limits.

[0018] [Oral Compositions] The oral composition of the present invention contains component (A), component (B), component (C) and component (D).

[0019] <(A) ingredient> (A) is sodium fluoride (NaF). (A) is a source of fluoride ions that have a caries-preventing effect. (A) can be a commercially available product.

[0020] <(B) Component> (B) The ingredient is a water-soluble calcium salt. (B) One ingredient may be used, or two or more ingredients may be used in combination. (B) Commercially available products may be used.

[0021] (B) Component preferably contains component (B1), wherein component (B1) is one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate and calcium pantothenate.

[0022] The proportion of component (B1) relative to the total mass of component (B) can be, for example, 90% or more by mass, 95% or more by mass, 96% or more by mass, 97% or more by mass, 98% or more by mass, or 99% or more by mass, or it can be 100% by mass.

[0023] <(C) Ingredients> (C) Component is at least one selected from the group consisting of condensed phosphates and their salts. (C) Component may be a combination of two or more. (C) Component may be a commercially available product.

[0024] Water-soluble condensed phosphoric acid or its salts are preferred as condensed phosphoric acid or its salts.

[0025] Examples of condensed phosphoric acid include linear polyphosphoric acids such as pyrophosphoric acid, tripolyphosphoric acid, and tetrapolyphosphoric acid; and cyclic polyphosphoric acids such as trimetaphosphoric acid, tetrametaphosphoric acid, and hexametaphosphoric acid.

[0026] The preferred salts for condensed phosphoric acid are alkali metal salts. Examples of alkali metal salts include sodium and potassium salts.

[0027] (C) preferably includes (C1), wherein (C1) is one or more selected from the group consisting of sodium tripolyphosphate, pyrophosphate, and alkali metal salts of pyrophosphate.

[0028] Examples of (C1) components include potassium pyrophosphate, sodium pyrophosphate, and sodium tripolyphosphate.

[0029] The proportion of component (C1) relative to the total mass of component (C) can be, for example, 90% or more by mass, 95% or more by mass, 96% or more by mass, 97% or more by mass, 98% or more by mass, or 99% or more by mass, or it can be 100% by mass.

[0030] <(D) Component> (D) Component is a zinc ion source. (D) Component is preferably a water-soluble zinc compound. (D) Component may be used in one or more combinations. (D) Component may be a commercially available product.

[0031] (D) Component preferably includes (D1) Component, wherein (D1) Component is selected from one or more of the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate, and zinc laurate.

[0032] The proportion of component (D1) relative to the total mass of component (D) can be, for example, 90% or more by mass, 95% or more by mass, 96% or more by mass, 97% or more by mass, 98% or more by mass, or 99% or more by mass, or it can be 100% by mass.

[0033] <Content of each component> The content of component (A) relative to the total mass of the oral composition is preferably 0.09 to 1.3% by mass, more preferably 0.10 to 1.1% by mass. When the content of component (A) is above the lower limit mentioned above, the fluoride ion retention is more excellent. When the content of component (A) is below the upper limit mentioned above, the flavor is more excellent.

[0034] The content of component (B) relative to the total mass of the oral composition is preferably 0.02 to 5.0% by mass, more preferably 0.03 to 3.0% by mass. When the content of component (B) is above the lower limit mentioned above, the fluoride ion retention is more excellent. When the content of component (B) is below the upper limit mentioned above, the flavor is more excellent. In addition, it is easier to suppress the formation of viscous substances.

[0035] The content of component (C) relative to the total mass of the oral composition is preferably 0.02 to 3.0% by mass, more preferably 0.03 to 1.3% by mass. When the content of component (C) is above the lower limit mentioned above, the fluoride ion retention is more excellent. When the content of component (C) is below the upper limit mentioned above, the flavor is more excellent.

[0036] The content of component (D) relative to the total mass of the oral composition is preferably 0.001 to 10% by mass, more preferably 0.01 to 2% by mass. When the content of component (D) is above the lower limit mentioned above, the effect of inhibiting the formation of viscous substances (viscous substance formation inhibition) is more excellent. When the content of component (D) is below the upper limit mentioned above, the flavor is more excellent.

[0037] The molar amount of zinc ions (unit: mmol / g) per 1g of oral composition is defined as Zn. mmol Zn mmol The preferred concentration is 0.0001~0.73 mmol / g, and more preferably 0.0007~0.15 mmol / g.

[0038] The molar ratio of component (B) to component (A) (hereinafter also referred to as "(B) / (A)") is preferably 0.01 to 10.0, more preferably 0.05 to 5.0. When (B) / (A) is within the above range, the fluoride ion retention is more excellent.

[0039] The molar ratio of component (C) to component (A) (hereinafter also referred to as "(C) / (A)") is preferably 0.005 to 1.5, more preferably 0.01 to 1.3. When (C) / (A) is within the above range, the fluoride ion retention is more excellent.

[0040] The molar ratio of component (B) to component (D) (hereinafter also referred to as "(B) / (D)") is preferably 0.01 to 300, more preferably 0.1 to 150. When (B) / (D) is above the lower limit value mentioned above, the flavor is more superior. When (B) / (D) is below the upper limit value mentioned above, the effect of inhibiting the formation of viscous substances (viscous substance formation inhibition) is more superior.

[0041] <Water> Oral compositions typically also contain water. Examples of water include purified water, sterile purified water, and water for injection.

[0042] The water content in oral compositions can be appropriately set according to the product form and method of use of the oral composition.

[0043] For example, when the oral composition is a liquid formulation, the water content relative to the total mass of the oral composition is preferably 10 to 99% by mass, more preferably 20 to 95% by mass, and even more preferably 30 to 90% by mass.

[0044] For example, when the oral composition is toothpaste, the water content relative to the total mass of the oral composition is preferably 5 to 90% by mass, more preferably 10 to 60% by mass, and even more preferably 20 to 50% by mass.

[0045] <Other Ingredients> Oral compositions may further contain other ingredients besides (A), (B), (C), (D) and water.

[0046] Other ingredients can be appropriately selected from known ingredients, taking into account the form and method of application of the oral composition. Examples of other ingredients include liquid media other than water, humectants, thickeners, surfactants, colorants, sweeteners, flavorings, active ingredients, pH adjusters, preservatives, and abrasives.

[0047] It should be noted that, when the oral composition is a product used in liquid form, it is preferably a liquid composition in which the compounding ingredients are dissolved or uniformly dispersed, and preferably does not contain insoluble solid components such as abrasives.

[0048] Examples of liquid media other than water include polyols such as glycerol, propylene glycol, and polyethylene glycol, which are liquids at 20°C, and lower monohydric alcohols with 2 or 3 carbon atoms such as ethanol.

[0049] Polyols are preferably added to act as humectants. When polyols are added, their content relative to the total mass of the oral composition is preferably 1 to 20% by mass, more preferably 3 to 15% by mass.

[0050] Lower monohydric alcohols are suitable for imparting a refreshing and cooling sensation during use, but irritation increases when the content exceeds 20%, potentially reducing the user experience. Furthermore, alcohol-free oral compositions that are substantially free of lower monohydric alcohols (containing less than 0.1% by mass of the total oral composition) are suitable as low-irritant oral compositions.

[0051] In addition to the polyols mentioned above, sugar alcohols such as sorbitol, maltitol, and lactitol can be cited as humectants.

[0052] The content of the humectant, based on the total amount of polyols contained, is preferably 2 to 20% by mass relative to the total mass of the oral composition, more preferably 3 to 20% by mass.

[0053] Examples of thickeners include sodium carboxymethyl cellulose, cellulose derivatives such as cationic cellulose, xanthan gum, and sodium alginate.

[0054] The content of thickener is preferably 0 to 5% by mass relative to the total mass of the oral composition, more preferably 0.01 to 4% by mass.

[0055] As a surfactant, it can be combined with known anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants.

[0056] Examples of anionic surfactants include: sodium lauryl sulfate, sodium myristyl sulfate, and other alkyl sulfates; sodium N-acyl sarcosinates such as sodium N-lauroyl sarcosinate and sodium N-myristyl sarcosinate; sodium dodecylbenzene sulfonate, sodium hydrogenated coconut fatty acid monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, and other N-acyl glutamate salts; sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acyl alanine, sodium α-olefin sulfonate, etc.

[0057] Examples of nonionic surfactants include: sucrose fatty acid esters, maltose fatty acid esters, maltitol fatty acid esters, lactitol fatty acid esters, and other sugar alcohol fatty acid esters; polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil; alkyl alcohol amides; polyoxyethylene sorbitan fatty acid esters; polyglycerol fatty acid esters; hexaglycerol monosphate; fatty acid diethanolamides; sorbitan fatty acid esters; and polyoxyethylene higher alcohol ethers.

[0058] Examples of cationic surfactants include alkylammonium salts and alkylbenzylammonium salts.

[0059] Examples of amphoteric surfactants include acetate-betaine type and imidazoline type.

[0060] As a coloring agent, highly safe water-soluble pigments such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105 can be added.

[0061] Examples of sweeteners include xylitol, maltitol, saccharin, sodium saccharin, steviol glycosides, and aspartame.

[0062] As a spice, for example: Peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, lavender oil, and golden button oil are among the natural essential oils available. L-menthol, L-carvone, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, eugenol, menthyl acetate, citral, camphor, borneol, pinene, spilanthol, and other fragrance components found in the above-mentioned natural essential oils. Fragrance ingredients include ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidyl ester, benzaldehyde, furanol, maltol, ethyl maltol, γ / δ-decanolide, γ / δ-undecaprolactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-L-menthyl carbonate. Flavoring agents are made by combining two or more of the following ingredients: apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat grape, wine, cherry, pumpkin, coffee, brandy, yogurt, etc. One spice may be used, or two or more spices may be used together.

[0063] The fragrance content is preferably 0.00001 to 3% by mass relative to the total mass of the oral composition.

[0064] As active ingredients, enzymes such as dextranase and mutagenase, nonionic bactericides such as isopropyl methylcellulose, polyglutamate, allantoin and its derivatives, azulene, lysozyme chloride, vitamins such as ascorbic acid, glycyrrhetinic acid, chlorophyll, sodium copper chlorophyllin, plant extracts such as thyme, copper gluconate, potassium nitrate, and aluminum lactate can be added. It should be noted that the content of these active ingredients can be set to an effective amount within a range that does not impair the effects of the present invention.

[0065] Examples of pH adjusters include citric acid, tartaric acid, malic acid, phosphoric acid, carbonic acid, and their salts (potassium salts, sodium salts, ammonium salts), ribonucleic acid and its salts, and sodium hydroxide.

[0066] Examples of preservatives include: methylparaben, ethylparaben, butylparaben, and other paraben esters; benzoic acid or its salts, such as sodium benzoate.

[0067] Examples of abrasives include: anhydrous silica, precipitated silica, silica gel, aluminum silicate, zirconium silicate, and other silica-based abrasives; dicalcium phosphate dihydrate or anhydrous dicalcium phosphate, calcium dihydrogen phosphate, calcium phosphate, tetracalcium phosphate, calcium carbonate, calcium hydroxide, aluminum hydroxide, insoluble sodium metaphosphate, magnesium phosphate, and magnesium carbonate. Silica-based abrasives are particularly preferred.

[0068] The content of the abrasive relative to the total mass of the oral composition is preferably 0 to 60% by mass, more preferably 0 to 30% by mass, and may also be 25% by mass or less. A content of 0% by mass of the abrasive indicates that it contains no abrasive.

[0069] <Form and dosage form> Oral compositions can be prepared in various forms, such as liquid, paste, gel, and solid.

[0070] There are no particular limitations on the dosage form of oral compositions. Typically, oral compositions are oral preparations that are expelled from the oral cavity after use. Examples of oral preparations include, for instance, dental flossers (liquid dental flossers, toothpaste, moisturizing dental flossers, powdered dental flossers, etc.), mouthwashes, rinses, ointments, oral sprays, patches, tablets, intraoral sustained-release preparations, chewing tablets, intraoral dissolving agents, intraoral disintegrants, tongue care agents, mouth cooling agents, and denture care agents.

[0071] The oral composition of this embodiment is suitable as a liquid formulation. The liquid formulation can be a stock solution type that is used directly, or a concentrated liquid formulation that is diluted before use.

[0072] Examples of liquid formulations include concentrated mouthwashes, concentrated mouthwashes, concentrated liquid dental floss, concentrated liquid dental floss, concentrated mouthwash, concentrated mouthwash, concentrated oral spray, and foaming spray liquid formulations. Liquid formulations other than liquid dental floss typically do not contain insoluble solid ingredients such as abrasives.

[0073] Liquid formulations can be, for example, in the form of a container body with a cap at the opening for removing the liquid formulation from the container body, the liquid formulation being contained in the container.

[0074] Examples of such caps include screw caps, toggle caps, push-pull caps, and pumps. In particular, toggle caps are preferred from the perspective that the cap tends to become difficult to open and close when viscous substances are generated, thus significantly improving the effectiveness of the present invention.

[0075] The toggle-type cap has, for example, a toggle-type button pivotally mounted to the cap body. The cap body has a liquid flow path communicating with the interior of the container, and the toggle-type button has a discharge port for discharging liquid and a liquid flow path connecting the discharge port to the liquid flow path of the cap body. In the toggle-type cap, by operating the toggle-type button, the position of the discharge port exposed to the outside and the position of the discharge port being covered can be switched, thereby switching between discharging and stopping the discharging of liquid from the container. For example, toggle-type caps known in Japanese Utility Model Application Publication No. 49-114015, Japanese Patent Application Publication No. 8-510978, and Japanese Patent No. 7154003 can be used.

[0076] For example, the pH of the undiluted mouthwash at 25°C is preferably 5.5 to 8.0, and more preferably 6.0 to 7.5.

[0077] For example, the viscosity of the undiluted mouthwash at 25°C is preferably 1~100 mPa·s, more preferably 2~50 mPa·s, and even more preferably 3~30 mPa·s.

[0078] In this specification, the viscosity of the oral composition is the value measured using a type B viscometer.

[0079] The oral composition of this embodiment can be prepared by known methods. For example, it can be prepared by mixing components (A), (B), (C), and (D), and other components as needed, using conventional methods.

[0080] In oral compositions, fluoride ions, calcium ions, and phosphorus ions form a complex that helps improve the retention of fluoride ions.

[0081] There are no particular limitations on the method for forming the above-mentioned complex. It is preferable to use either a step of combining component (B) after combining components (A) and (C) or a step of combining component (A) after combining components (B) and (C) when preparing the oral composition. It should be noted that when components (A) and (B) are combined simultaneously, calcium fluoride may be partially generated, which reduces the efficiency of complex formation.

[0082] The oral composition described above, containing components (A), (B) and (C), not only exhibits excellent fluoride ion retention but also inhibits the formation of viscous substances due to the presence of component (D).

[0083] [Example] The present invention is described in detail below with reference to embodiments, but the present invention is not limited thereto.

[0084] In addition, in the following examples, unless otherwise specified, the content unit "%" means "mass%".

[0085] <Raw Materials Used> [(A) Ingredient] Sodium fluoride: Manufactured by Stella Chemifa Co., Ltd. Also referred to as "NaF" below.

[0086] [(B) Component] Calcium lactate hydrate: Manufactured by Taihei Chemical Industry Co., Ltd., trade name "Calcium Lactate". Also referred to below as "Ca Lactate".

[0087] Calcium gluconate: Manufactured by Fuso Chemical Industry Co., Ltd. Also referred to below as "Calcium gluconate (Ca)".

[0088] Calcium glycerophosphate: Manufactured by Iwaki Pharmaceutical Co., Ltd. Hereinafter also referred to as "Calcium glycerophosphate (Ca)".

[0089] Calcium chloride: Manufactured by Tomita Pharmaceutical Co., Ltd. Hereinafter also referred to as "Ca chloride".

[0090] Calcium pantothenate: Manufactured by BASF. Also referred to below as "Pamoate (Ca)".

[0091] [(C) Component] Tetrapotassium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "K pyrophosphate".

[0092] Sodium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd., product name "Sodium pyrophosphate (anhydrous)". Hereinafter also referred to as "Na pyrophosphate".

[0093] Sodium tripolyphosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Hereinafter also referred to as "Na tripolyphosphate".

[0094] [(D) component] Zinc chloride: Manufactured by Junsei Chemical Co., Ltd.

[0095] Zinc gluconate: Manufactured by Tokyo Chemical Industry Co., Ltd.

[0096] Zinc stearate: Manufactured by Fujifilm and Kazuko Pure Chemical Industries, Ltd.

[0097] Zinc myristate: Manufactured by Nippon Oil Co., Ltd.

[0098] Zinc laurate: Manufactured by Tokyo Chemical Industry Co., Ltd.

[0099] [water] Purified water.

[0100] [Common components (any components)] Glycerin (liquid medium) 7.5%, Propylene glycol (liquid medium) 3%, Sorbitol (humectant) 5%, Citric acid (pH adjuster) 0.1%, Sodium citrate (pH adjuster) 0.2%, Fragrance 0.2%. Total 16.0%.

[0101] <Examples 1-25, Comparative Examples 1-4> Oral compositions (mouthwashes) with the compositions shown in Tables 1-4 were prepared using conventional methods. A premix was prepared by mixing aqueous solutions of component (C), component (B), and component (A) in the following order: water. The amount of water was set to meet the requirements of the compositions shown in the table. An aqueous solution of component (D) and any other component were added to this premix, and the mixture was stirred at room temperature to obtain the oral composition. The pH of the oral composition at 25°C was in the range of 6-7.

[0102] In any of the examples, the viscosity of the oral composition at 25°C was in the range of 4 ± 1 mPa·s.

[0103] Empty columns in the table indicate that the ingredient was not incorporated. The "balance" of purified water indicates the amount needed to make the total amount of the oral composition 100%.

[0104] The obtained oral compositions were evaluated as follows. The results are recorded in the table.

[0105] <Evaluation Methods> [Fluoride ion retention] Six-mm x six-mm square sections made from bovine tooth enamel were immersed for 3 minutes in a solution containing a 4-fold dilution of oral composition with purified water, followed immediately by rinsing three times with purified water. After drying, the sections were extracted by contacting the surface with 120 μL of artificial saliva for 3 minutes. The concentration of extracted fluoride ions was determined using an ion meter (Thermo Fisher Scientific, Inc., product name "Orion 1115000 4-Star"), and the average of the data (N=3) was taken as the fluoride ion retention (unit: ppm (mass standard)). Chloride ion retention was evaluated according to the following criteria.

[0106] (Evaluation Criteria) ◎: Fluoride ion retention is above 0.3 ppm.

[0107] 〇: Fluoride ion retention is above 0.2 ppm and less than 0.3 ppm.

[0108] △: Fluoride ion retention is above 0.1 ppm and less than 0.2 ppm.

[0109] ×: Fluoride ion retention is less than 0.1 ppm.

[0110] [Inhibition of Viscosity Formation (Opening Torque Test)] The cap and container body described in Example 1 of Japanese Patent No. 7154003 were used. The oral composition was filled into the container body, and the cap was tightened to seal with a torque of 0.05 MPa. The container was inverted with the cap facing downwards and left to stand at 50°C for 30 days. The opening torque after standing was measured and evaluated according to the following criteria.

[0111] (Evaluation Criteria) ◎: The torque in Kaifeng is above 200 cN·m and less than 300 cN·m.

[0112] ○: The torque for opening the window is above 300 cN·m and less than 400 cN·m.

[0113] △: The torque for opening the window is above 400 cN·m and less than 500 cN·m.

[0114] ×: The torque for opening the gate is above 500 cN·m.

[0115] [Flavor] Evaluation was conducted through sensory testing by a panel of 10 experts who served as subjects. Each participant rinsed their mouth with 10 mL of the oral composition for 30 seconds and rated the perceived odor according to the following scoring criteria. The average score from the 10 participants was calculated, and the flavor (degree of odorlessness) was evaluated using the following evaluation criteria.

[0116] (Scoring criteria) 4 points: No unusual odor was detected.

[0117] 3 points: There is a slight odor, but there are no problems with its use.

[0118] 2 points: There is an odor, indicating a problem with its use.

[0119] 1 point: I strongly felt an odor.

[0120] (Evaluation Criteria) ◎: Average score of 3.5 or above.

[0121] ○: The average score is 3.0 or higher but less than 3.5.

[0122] △: The average score is above 2.0 and below 3.0.

[0123] ×: Average score is less than 2.0.

[0124] [Table 1]

[0125] [Table 2]

[0126] [Table 3]

[0127] [Table 4]

[0128] As shown in Tables 1-4, the oral compositions of Examples 1-25 not only exhibit excellent fluoride ion retention but also good inhibition of viscous formation. Furthermore, they also possess good flavor.

[0129] On the other hand, Comparative Example 1, which does not contain component (A), Comparative Example 2, which does not contain component (B), and Comparative Example 3, which does not contain component (C), exhibited poor fluoride ion retention. Comparative Example 2 also had a poor flavor.

[0130] Comparative Example 4, which does not contain component (D), exhibits poor inhibition of viscous formation.

[0131] ≪Formula Example≫ In any of the following formulations, excellent fluoride ion retention and good inhibition of viscosity formation are observed. Furthermore, the flavor is also good.

[0132] <Formula Example 1: Toothpaste> Sodium fluoride 0.32% Calcium glycerol phosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.01% 10% anhydrous silica Sorbitol solution (70% concentration) 40% 3% propylene glycol Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fat, amamidopropyl betaine 0.5% Sodium saccharin 0.2% 1% of spices Purified water balance <Formula Example 2: Toothpaste> Sodium fluoride 0.32% Calcium glycerol phosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.1% 10% anhydrous silica Sorbitol solution (70% concentration) 40% 3% propylene glycol Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fat, amamidopropyl betaine 0.5% Sodium saccharin 0.2% 1% of spices Purified water balance <Formula Example 3: Toothpaste> Sodium fluoride 0.32% Calcium glycerol phosphate 0.2% Sodium pyrophosphate 0.1% 1% zinc chloride 10% anhydrous silica Sorbitol solution (70% concentration) 40% 3% propylene glycol Xanthan gum 0.5% Sodium polyacrylate 0.5% Coconut oil fat, amamidopropyl betaine 0.5% Sodium saccharin 0.2% 1% of spices Purified water balance <Formulation Example 4 Oral Spray> Sodium fluoride 0.32% Calcium glycerol phosphate 0.2% Sodium pyrophosphate 0.1% Zinc chloride 0.1% 3% glycerol 3% propylene glycol Xylitol 2% Polyoxyethylene hydrogenated castor oil (100E.O) 0.2% Methylparaben 0.05% Citric acid 0.05% Sodium citrate 0.2% Sodium saccharin 0.01% 0.2% of spices The remaining amount of purified water.

Claims

1. An oral composition, characterized in that, contain: (A) Ingredients: Sodium fluoride, (B) Ingredients: Water-soluble calcium salts, (C) Components: at least one selected from the group consisting of condensed phosphates and their salts, and (D) Component: Zinc ion source.

2. The oral composition according to claim 1, wherein, The (B) component comprises one or more selected from the group consisting of calcium chloride, calcium gluconate, calcium lactate, calcium glycerophosphate, and calcium pantothenate.

3. The oral composition according to claim 1, wherein, The (C) component comprises one or more selected from the group consisting of sodium tripolyphosphate, pyrophosphate, and alkali metal salts of pyrophosphate.

4. The oral composition according to claim 1, wherein, The (D) component comprises one or more selected from the group consisting of zinc chloride, zinc gluconate, zinc stearate, zinc myristate, and zinc laurate.

5. The oral composition according to claim 1, wherein, The molar ratio of component (B) to component (D), expressed as (B) / (D), is 0.01 to 300.

6. The oral composition according to claim 1, wherein, The molar ratio of component (B) to component (A) is 0.01 to 10.

0.

7. The oral composition according to claim 1, wherein, The molar ratio of component (C) to component (A) is 0.005 to 1.

5.

8. The oral composition according to claim 1, wherein, The content of component (A) is 0.09 to 1.3% by mass relative to the total mass of the oral composition.

9. The oral composition according to claim 1, wherein, The content of component (B) is 0.02 to 5.0% by mass relative to the total mass of the oral composition.

10. The oral composition according to claim 1, wherein, The content of component (C) is 0.02 to 3.0% by mass relative to the total mass of the oral composition.

11. The oral composition according to claim 1, wherein, The content of component (D) is 0.001 to 10% by mass relative to the total mass of the oral composition.

12. The oral composition according to claim 1, wherein, The molar amount of zinc ions (Zn) per 1g of the oral composition. mmol The values ​​range from 0.0001 to 0.73 mmol / g.

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