Far-end discharge suspension electrode jet pipe for atomizing enhanced active products

Abstract

The invention discloses a far-end discharge suspension electrode jet tube for atomizing enhanced active products. The far-end discharge suspension electrode jet tube comprises a dielectric tube, a PLA (polylactic acid) bracket, a ring electrode, a flexible tube I, an induction conductor and a flexible tube II, the problem that the discharge position is limited is solved, the device can flexibly act on deep tissues, complex cavities and long-distance targets, and far-end precise treatment is achieved. According to the invention, the active product can be enhanced and the ozone content can be reduced at the far end, the sterilization, anti-tumor and oxidation treatment effects are improved, and the risk of oxidative damage to tissues is reduced at the same time. The device has higher safety guarantee in clinical application and human body cavity operation. The flexible silicone tube has flexibility and biocompatibility and can safely enter a human body cavity or be attached to skin tissue, and tissue damage, rejection and discomfort are remarkably reduced. Meanwhile, the length of the flexible silicone tube can reach 2 meters, the flexible silicone tube can be arranged along with the bending form of the cavity channel, and accurate discharging of a deep target is achieved. The treatment effect is adjustable, the application range is wide, operation is easy and convenient, and controllability is high.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a distal discharge suspended electrode jet tube for atomizing and enhancing active products. Background Technology

[0002] Atomized plasma discharge technology is an advanced oxidation technology that combines liquid atomization with plasma discharge. In clinical medical applications, it is used for skin surface disinfection and wound treatment. A handheld jet probe sprays the plasma onto the wound surface, where atomized water vapor and plasma converge at the outlet, enhancing the inactivation ability of aqueous / interfacial reactive species (such as hydroxyl radicals and hydrogen peroxide precursors) against bacteria / fungi / viruses while reducing ozone exposure. It is also used for distal ablation and local treatment within endoscopes / bronchoscopes (such as lung tumors). In the field of medical devices and aseptic processing, it is used for disinfection of the lumens of endoscopes, catheters, and instruments. In the treatment of acne and skin lesions / cosmetic disinfection, it reduces skin dryness and irritation, and improves anti-infection and repair effects.

[0003] Traditional direct electrode discharge structures: Existing atmospheric pressure cryogenic plasma jet devices mostly employ needle-shaped or ring-shaped electrodes directly arranged within the nozzle or gas channel. A high-voltage electric field is applied to ionize the gas and form a plasma jet. The electrodes are tightly coupled to the discharge region, the discharge position is fixed at the nozzle end, and the jet length is limited. Because the electrodes are directly exposed to the high-voltage environment, there are risks of electric shock, electrode ablation, and operational safety hazards. Furthermore, it is difficult to stably generate far-end discharges over long distances or in curved channels.

[0004] Dielectric barrier discharge (DBD) jet tubes: Some technologies use glass or ceramic tubes as the dielectric, with annular or spiral electrodes on the outside of the tube wall, and internal gas channels forming a dielectric barrier discharge structure. Driven by a high-voltage power supply, the gas forms a plasma jet at the outlet. Dielectric barrier discharge effectively prevents the electrodes from directly contacting the gas flow, making the discharge relatively safe and the jet stable. However, due to the rigidity of the tube material and the limitation of the discharge by the dielectric, the discharge location is limited to the nozzle end, making it impossible to achieve discharge treatment at remote ends or in flexible cavities.

[0005] Conductor structures for long-distance potential transfer: Existing technologies attempt to transfer high-voltage potentials to distant locations by extending metal wires or conductors to achieve discharges at long distances from the power source. The wire extends along a conduit or flexible sheath to the target area, where a discharge occurs at the end. However, most devices use only bare wires or simple insulation for protection, with the wire directly coupled to the discharge area, posing risks of leakage, dielectric breakdown, and potential damage to biological tissues. Furthermore, the wire lacks fixed support, making it prone to deformation or displacement during long-distance transmission, leading to unstable discharges at the distant end.

[0006] Wet-phase enhancement and ozone control technology: Some existing technologies employ downstream water vapor or atomized injection, liquid electrodes, gas humidification, or low-concentration oxygen doping to increase the generation rate of active substances at the gas-liquid interface or inhibit ozone accumulation. The atomizing or water vapor injection port is located downstream of the nozzle, typically within tens of millimeters; the water vapor flow rate or carrier gas humidity is controlled to promote hydroxyl radical (hydroxyl radical) production by increasing local relative humidity. These technologies generate and reduce ozone; some employ airflow stratification, nozzle geometry optimization, or pulse parameter adjustment to achieve localized enhancement of active substances and ozone suppression. However, these technologies are typically modular designs that are difficult to simultaneously address with long-distance flexible jet tubes, remote potential transfer, and biocompatibility safety requirements, thus limiting their application in curved or human body cavities. Summary of the Invention

[0007] The purpose of this invention is to provide a distal discharge suspended electrode jet tube for atomizing and enhancing active products, comprising: a dielectric tube, a PLA support, a ring electrode, a flexible tube I, an inductive conductor, and a flexible tube II.

[0008] The dielectric tube is a hollow columnar structure, with one end connected to an external gas generating device and the other end connected to a flexible tube I, forming a working gas jet channel.

[0009] The PLA bracket is installed inside the dielectric tube to fix the induction conductor.

[0010] The sensing conductor extends from inside the dielectric tube to the end of the flexible tube I, and the surface of the sensing conductor is covered with an insulating layer.

[0011] The ring electrode surrounds the outer wall of the dielectric tube.

[0012] The ring electrode is electrically connected to an external pulse generator.

[0013] The flexible tube II is sleeved on the outside of the flexible tube I, and one end abuts against the dielectric tube.

[0014] The end of the flexible tube II extends beyond the end of the flexible tube I.

[0015] The flexible tube II has an atomization interface on the side near the dielectric tube. The atomization interface is connected to the atomizer to form an atomized liquid jet channel.

[0016] Both flexible tube I and flexible tube II are made of biocompatible materials.

[0017] When performing remote atomization discharge using the jet tube, the end of the flexible tube II is placed in front of the object to be sprayed. An external gas generating device inputs working gas, and an external pulse generator generates an electrical signal on the ring electrode, which in turn generates electromagnetic induction coupling with the induction conductor. The induction conductor generates an induced potential at the end of the flexible tube I. The working gas undergoes primary ionization in the dielectric tube and secondary ionization as it flows through the end of the flexible tube I, generating a plasma jet. The atomizer inputs atomizing liquid, which combines with the plasma jet at the end of the flexible tube II, outputting a plasma jet with enhanced active products, which then acts on the object to be sprayed.

[0018] Furthermore, a gas flow meter is also provided between the dielectric tube and the external gas generating device.

[0019] The gas flow meter is used to control the input flow rate and ratio of the working gas.

[0020] The input flow rate of the working gas is in the range of 0.5L / min to 10L / min.

[0021] The gas flow meter includes a gas mass flow controller and a flow-limiting orifice plate.

[0022] Furthermore, the dielectric tube is made of materials including quartz, borosilicate glass, alumina ceramic, and high-silicon glass.

[0023] The biocompatible materials include silicone and polytetrafluoroethylene.

[0024] Furthermore, the insulating layer is made of materials including polyesterimide and fluoroplastics.

[0025] Furthermore, the external pulse generator includes a pulse power supply and a frequency-modulated AC power supply.

[0026] The electrical signal generated on the ring electrode by the external pulse generator includes a square wave pulse voltage.

[0027] The square wave pulse voltage has an amplitude range of 6kV-9kV, a pulse width range of 200ns-2000ns, and a frequency range of 5kHz-10kHz.

[0028] Furthermore, the sensing conductor includes a suspended metal wire electrode and a hollow needle electrode.

[0029] The material used for the inductive conductor includes copper.

[0030] Furthermore, the length of the flexible tube ranges from 0 to 2 meters.

[0031] Furthermore, the working gas includes at least one of helium, argon, nitrogen, and oxygen.

[0032] The atomized liquid includes water and physiological saline.

[0033] The enhanced active product includes .

[0034] Furthermore, the PLA bracket includes a ceramic sleeve and a 3D-printed bracket.

[0035] Furthermore, the atomizer includes an ultrasonic atomizer, a capillary jet atomizing device, a micro-mist generator, a heating steam device, and a water-vapor mixer.

[0036] The flow rate of the atomized liquid ranges from 0.5 L / min to 5 L / min.

[0037] The technical effects of this invention are undeniable, and this invention has the following beneficial effects:

[0038] 1. Significantly Enhanced Discharge Capability: By insulated copper wires extending from the glass tube to the end of the PTFE / silicone tube, combined with ring electrode inductive coupling, stable plasma discharge is directly generated at the distal end. Compared to existing devices that can only discharge at the nozzle or proximal end, this invention overcomes the limitation of discharge location, allowing for flexible application to deep tissues, complex cavities, and long-distance targets, achieving precise distal treatment.

[0039] 2. Enhanced Active Products through Atomization: Water vapor or micro-mist is introduced into the sidewall of the flexible silicone tube, allowing the atomized water vapor to merge with the distal plasma. This significantly increases the generation of hydroxyl radicals (·OH) and other wet-phase active substances, while simultaneously inhibiting ozone accumulation. Compared to traditional dry gas plasma jets, this invention achieves enhanced active products and reduced ozone content at the distal end, improving bactericidal, antitumor, and oxidative treatment effects while reducing the risk of oxidative damage to tissues.

[0040] 3. High safety: The copper wire is completely covered with a polyesterimide insulation layer, preventing direct contact with the patient and avoiding the risks of electric shock, leakage, and breakdown during high-voltage conduction. Compared with bare wires or simply insulated wires, this invention provides a higher level of safety in clinical applications and procedures involving human cavities.

[0041] 4. Biocompatibility and Flexibility: The jet tube employs a PLA support for copper wires and a medical-grade silicone tube encased in a PTFE tube, combining flexibility and biocompatibility. This allows for safe insertion into body cavities or adherence to skin tissue, significantly reducing tissue damage, rejection, and discomfort. Furthermore, the flexible silicone tube can reach lengths of up to 2 meters, adapting to the curvature of body cavities for precise discharge to deep targets.

[0042] 5. Adjustable treatment effect: By adjusting the working gas flow rate, atomized water vapor injection rate and high-pressure square wave pulse parameters, the plasma jet length, discharge intensity and active substance concentration can be flexibly controlled to achieve personalized treatment for different tissue types or disease states.

[0043] 6. Multi-scenario applications: This invention can be used not only for skin sterilization, wound repair, and surface disinfection, but also for local anti-tumor and anti-infection treatment in deep cavities such as the respiratory and digestive tracts. It can also be extended to various scenarios such as internal disinfection of medical devices, surface modification of materials, and treatment of active substances in laboratories, making its application scope wide.

[0044] 7. The system is easy to operate and highly controllable: Combining the gas control module, the high-voltage pulse generation module and the feedback adjustment system, this invention can monitor the gas flow rate, voltage and discharge status in real time, ensuring stable output of remote plasma. It is easy to operate, highly repeatable, and can quickly adjust parameters according to treatment needs. Attached Figure Description

[0045] Figure 1 This is a schematic diagram of the structural composition of each module of the present invention;

[0046] Figure 2 This is a schematic diagram of the plasma control delivery system in this invention;

[0047] Figure 3 This is a schematic diagram of the discharge system of the present invention;

[0048] Figure 4 This is a flowchart of the workflow of the present invention;

[0049] Figure 5 A schematic diagram of plasma generation at a remote location; Figure 5 (a) is a schematic diagram of remote discharge; Figure 5 (b) is a schematic diagram of discharge at the end of the flexible tube;

[0050] Figure 6 Schematic diagram of ozone concentration change after atomization.

[0051] Figure 7 Schematic diagram of the spectral detection results of active products of plasma jet at the tail end of the tube with different media wall thickness;

[0052] Figure 8 A schematic diagram showing the comparison of Tunel staining for apoptosis before and after the application of water vapor; Figure 8 (a) Schematic diagram of Tunel staining for apoptosis before water vapor is applied; Figure 8 (b) Schematic diagram of Tunel staining for cell apoptosis after the application of water vapor; Figure 8 (c) Schematic diagram of Tunel / Dapi double staining for apoptosis before water vapor application; Figure 8(d) is a schematic diagram of Tunel / Dapi double staining for cell apoptosis after the application of water vapor;

[0053] In the diagram: 1. Dielectric tube; 2. PLA support; 3. Ring electrode; 4. Flexible tube I; 5. Induction conductor; 6. Flexible tube II; 7. Atomizing interface; 8. Atomizer; 9. External pulse generator; 10. Gas flow meter; 11. External gas generating device. Detailed Implementation

[0054] The present invention will be further described below with reference to embodiments, but it should not be construed that the scope of the present invention is limited to the following embodiments. Various substitutions and modifications made based on ordinary technical knowledge and common practices in the art without departing from the above-described technical concept of the present invention should be included within the scope of protection of the present invention.

[0055] Example 1:

[0056] See Figures 1 to 8 A distal discharge suspended electrode jet tube for atomizing and enhancing active products includes: a dielectric tube 1, a PLA support 2, a ring electrode 3, a flexible tube I 4, an inductive conductor 5, and a flexible tube II 6.

[0057] The dielectric tube 1 is a hollow columnar structure, with one end connected to the external gas generating device 11 and the other end connected to the flexible tube I4, forming a working gas jet channel.

[0058] The PLA bracket 2 is installed inside the dielectric tube 1 and is used to fix the induction conductor 5.

[0059] The inductive conductor 5 extends from inside the dielectric tube 1 to the end of the flexible tube I4, and the surface of the inductive conductor 5 is covered with an insulating layer.

[0060] The ring electrode 3 is surrounded on the outer wall of the dielectric tube 1.

[0061] The ring electrode 3 is electrically connected to the external pulse generator 9.

[0062] The flexible tube II6 is sleeved on the outside of the flexible tube I4, and one end abuts against the dielectric tube 1.

[0063] The end of the flexible tube II6 extends beyond the end of the flexible tube I4.

[0064] The flexible tube II6 is provided with an atomization interface 7 on the side near the dielectric tube 1. The atomization interface 7 is connected to the atomizer 8 to form an atomized liquid jet channel.

[0065] Both the flexible tube I4 and the flexible tube II6 are made of biocompatible materials.

[0066] When performing remote atomization discharge using the jet tube, the end of the flexible tube II6 is placed in front of the object to be sprayed. The external gas generating device 11 inputs working gas, and the external pulse generator 9 generates an electrical signal on the ring electrode 3, which in turn generates electromagnetic induction coupling with the induction conductor 5. The induction conductor 5 generates an induced potential at the end of the flexible tube I4. The working gas undergoes primary ionization in the dielectric tube 1 and secondary ionization as it flows through the end of the flexible tube I4, generating a plasma jet. The atomizer 8 inputs atomizing liquid, which combines with the plasma jet at the end of the flexible tube II6, outputting a plasma jet with enhanced active products, which then acts on the object to be sprayed.

[0067] Example 2:

[0068] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in Example 1, further wherein a gas flow meter 10 is provided between the dielectric tube 1 and the external gas generating device 11.

[0069] The gas flow meter 10 is used to control the input flow rate and ratio of the working gas.

[0070] The input flow rate of the working gas is in the range of 0.5L / min to 10L / min.

[0071] The gas flow meter 10 includes a gas mass flow controller and a flow-limiting orifice plate.

[0072] Example 3:

[0073] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 2. Further, the dielectric tube 1 is made of materials including quartz, borosilicate glass, alumina ceramic, and high-silicon glass.

[0074] The biocompatible materials include silicone and polytetrafluoroethylene.

[0075] Example 4:

[0076] A distal discharge suspended electrode jet tube for atomizing enhanced active products, the main technical contents of which are described in any one of Examples 1 to 3, further wherein the insulating layer is made of materials including polyesterimide and fluoroplastics.

[0077] Example 5:

[0078] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 4, further wherein the external pulse generator 9 includes a pulse power supply and a frequency-modulated AC power supply.

[0079] The electrical signal generated on the ring electrode 3 by the external pulse generator 9 includes a square wave pulse voltage.

[0080] The square wave pulse voltage has an amplitude range of 6kV-9kV, a pulse width range of 200ns-2000ns, and a frequency range of 5kHz-10kHz.

[0081] Example 6:

[0082] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 5, further wherein the inductive conductor 5 includes a suspended metal wire electrode and a hollow needle electrode.

[0083] The material used for the inductive conductor 5 includes copper.

[0084] Example 7:

[0085] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 6, further wherein the length of the flexible tube 4 is in the range of 0-2m.

[0086] Example 8:

[0087] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 7, further wherein the working gas includes at least one of helium, argon, nitrogen and oxygen.

[0088] The atomized liquid includes water and physiological saline.

[0089] The enhanced active product includes .

[0090] Example 9:

[0091] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 8, further wherein the PLA support 2 includes a ceramic sleeve and a 3D printed support.

[0092] Example 10:

[0093] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 1 to 9. Further, the atomizer 8 includes an ultrasonic atomizer, a capillary jet atomizing device, a micro-mist generator, a heating steam device, and a water-vapor mixer.

[0094] The flow rate of the atomized liquid ranges from 0.5 L / min to 5 L / min.

[0095] Example 11:

[0096] See Figures 1 to 8A distal discharge suspended electrode jet tube for atomizing and enhancing active products includes: a dielectric tube 1, a PLA support 2, a ring electrode 3, a flexible tube I 4, an inductive conductor 5, and a flexible tube II 6.

[0097] The dielectric tube 1 is a hollow columnar structure, with one end connected to the external gas generating device 11 and the other end connected to the flexible tube I4, forming a working gas jet channel.

[0098] The jet tube is made of a quartz glass tube with a thickness of 1 mm to balance good discharge performance and mechanical strength. A high-voltage discharge ring electrode surrounds the outside of the glass tube, forming a primary dielectric barrier discharge region to achieve primary ionization of the gas.

[0099] The PLA bracket 2 is installed inside the dielectric tube 1 to fix the induction conductor 5, ensuring the stability of the conductor position and the controllability of the discharge point during long-distance transmission.

[0100] The inductive conductor 5 extends from inside the dielectric tube 1 to the end of the flexible tube I4, and the surface of the inductive conductor 5 is covered with an insulating layer to prevent electric shock and leakage current.

[0101] The ring electrode 3 is surrounded on the outer wall of the dielectric tube 1.

[0102] The ring electrode 3 is electrically connected to the external pulse generator 9.

[0103] The flexible tube II6 is sleeved on the outside of the flexible tube I4, and one end abuts against the dielectric tube 1.

[0104] The end of the flexible tube II6 extends beyond the end of the flexible tube I4.

[0105] The flexible tube II6 is provided with an atomization interface 7 on the side near the dielectric tube 1. The atomization interface 7 is connected to the atomizer 8 to form an atomized liquid jet channel.

[0106] Both the flexible tube I4 and the flexible tube II6 are made of biocompatible materials, and the tube diameter and length can be selected according to the application.

[0107] When performing remote atomization discharge using the jet tube, the end of the flexible tube II6 is placed in front of the object to be sprayed. The external gas generating device 11 inputs working gas, and the external pulse generator 9 generates an electrical signal on the ring electrode 3, which in turn generates electromagnetic induction coupling with the induction conductor 5. The induction conductor 5 generates an induced potential at the end of the flexible tube I4. The working gas undergoes primary ionization in the dielectric tube 1 and secondary ionization as it flows through the end of the flexible tube I4, generating a plasma jet. The atomizer 8 inputs atomizing liquid, which combines with the plasma jet at the end of the flexible tube II6, outputting a plasma jet with enhanced active products, reducing ozone concentration, and acting on the object to be sprayed.

[0108] Example 12:

[0109] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in Example 11, further wherein a gas flow meter 10 is provided between the dielectric tube 1 and the external gas generating device 11.

[0110] The gas flow meter 10 is used to control the input flow rate and ratio of the working gas.

[0111] The input flow rate of the working gas is in the range of 0.5L / min to 10L / min.

[0112] The gas flow meter 10 includes a gas mass flow controller and a flow-limiting orifice plate.

[0113] Example 13:

[0114] A far-end discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 12. Further, the dielectric tube 1 is made of materials including quartz, borosilicate glass, alumina ceramic, high-silicon glass, or other materials with good thermal stability and dimensional stability.

[0115] The biocompatible materials include silicone and polytetrafluoroethylene.

[0116] Example 14:

[0117] A distal discharge suspended electrode jet tube for atomizing enhanced active products, the main technical contents of which are described in any one of Examples 11 to 13, further wherein the insulating layer is made of materials including polyesterimide and fluoroplastics.

[0118] Example 15:

[0119] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 14, further wherein the external pulse generator 9 includes a pulse power supply and a frequency-modulated AC power supply.

[0120] The electrical signal generated on the ring electrode 3 by the external pulse generator 9 includes a square wave pulse voltage.

[0121] The square wave pulse voltage has an amplitude range of 6kV-9kV, a pulse width range of 200ns-2000ns, and a frequency range of 5kHz-10kHz.

[0122] Example 16:

[0123] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 15, further wherein the inductive conductor 5 includes a suspended metal wire electrode and a hollow needle electrode.

[0124] The material used for the inductive conductor 5 includes copper.

[0125] Example 17:

[0126] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 16, further wherein the length of the flexible tube 4 is in the range of 0-2m.

[0127] Example 18:

[0128] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 17, further wherein the working gas includes at least one of helium, argon, nitrogen and oxygen.

[0129] The atomized liquid includes water and physiological saline.

[0130] The enhanced active product includes .

[0131] Example 19:

[0132] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 18, further wherein the PLA support 2 includes a ceramic sleeve and a 3D printed support.

[0133] Example 20:

[0134] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 11 to 19. Further, the atomizer 8 includes an ultrasonic atomizer, a capillary jet atomizing device, a micro-mist generator, a heating steam device, and a water-vapor mixer.

[0135] The flow rate of the atomized liquid ranges from 0.5 L / min to 5 L / min.

[0136] Example 21:

[0137] See Figures 1 to 8 A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which include:

[0138] Structural components:

[0139] 1. Discharge region structure

[0140] The jet tube is mainly composed of a quartz glass tube, with one end connected to the high-voltage power supply area and the other end connected to a flexible tube. The glass tube is 1 mm thick to balance good discharge performance and mechanical strength. A high-voltage discharge ring electrode surrounds the outside of the glass tube, forming a primary dielectric barrier discharge region to achieve primary ionization of the gas.

[0141] 2. Suspended electrode structure

[0142] A 3D-printed PLA bracket is installed inside the glass tube to support an extended copper wire that extends to the end of the flexible tube to achieve long-distance potential transfer. The surface of the copper wire is covered with a polyesterimide insulation layer to prevent electric shock and leakage current. The PLA bracket fixes the position of the copper wire, ensuring the stability of the conductor position during long-distance transmission and making the discharge point controllable.

[0143] 3. Flexible remote pipeline

[0144] The other end of the glass tube is connected to a polytetrafluoroethylene (PTFE) tube, the diameter and length of which can be selected according to the application. The PTFE tube is wrapped with a biocompatible silicone tube, the sidewall of which has a water vapor / nebulization inlet. Nebulized water or saline solution can be introduced into the tube to achieve wet-phase enhancement. A water vapor and plasma convergence zone is formed at the PTFE tube outlet, enhancing the generation of active products and reducing ozone concentration through turbulent mixing.

[0145] Working principle and working method:

[0146] The working gas may include one or more of helium, argon, nitrogen, and oxygen. The gas flow rate is controlled by a high-precision mass flow controller (MFC), and the flow rate can be adjusted within the range of 0.5–10 L / min. A small amount of oxygen can be added to the working gas to regulate the generation of active substances and ozone concentration.

[0147] An external high-voltage square wave pulse power supply is used, with an output voltage range of 6–9 kV, a pulse width of 200–2000 ns, and a frequency of 5–10 kHz. Primary ionization is generated at the discharge ring in the glass tube, inducing a secondary discharge along the copper wire to the distal end of the PTFE / silicone tube, thus generating distal plasma. The copper wire insulation layer ensures operational safety, while the PLA bracket provides positional fixation, improving the stability of the distal discharge. The silicone tube sidewall has an atomization interface, allowing water vapor to be introduced via a micro-mist generator or a heated steam device, with an adjustable flow rate (e.g., 0.5–5 L / min). At the outlet, the water vapor merges with the plasma generated by the distal discharge, promoting hydroxyl radicals at the gas-liquid interface. It generates wet-phase active substances such as ozone and inhibits ozone accumulation.

[0148] Example 22:

[0149] See Figures 1 to 8 A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which include:

[0150] Please see the appendix Figure 1 A biocompatible suspended electrode jet tube includes the following components:

[0151] Dielectric tube 1: The tube wall thickness is about 1 mm. It has good dielectric properties and mechanical strength, and can maintain stable discharge characteristics without easily breaking.

[0152] PLA bracket 2: Made by 3D printing, it is used to fix the suspended metal wire electrode inside the dielectric tube to ensure the stability of the electrode position.

[0153] High voltage electrode 3: Located in a ring position outside the dielectric tube, used to connect to an external high voltage power supply.

[0154] Silicone tubing 4: Made of polytetrafluoroethylene tubing with good insulation properties, with a wall thickness of about 0.3 mm, combining flexibility and insulation properties, effectively avoiding the risk of electric shock.

[0155] Suspended copper wire electrode 5: Extends along the inside of the dielectric tube and silicone tube, and the outer surface of the copper wire is covered with a polyesterimide insulating layer to prevent electric shock and leakage current.

[0156] Silicone tubing 6: Approximately 1mm thick, offering good biocompatibility and enhanced insulation. It also traps water vapor.

[0157] Atomizer inlet 7: An interface for connecting the atomizer is provided, which allows the space between the PTFE tube and the silicone tube to be filled with water vapor for activation.

[0158] Through the above structure, the device achieves near-end voltage loading, far-end safe discharge, and enhanced activation gas composition (the plasma active component includes...). It has the function of reducing ozone.

[0159] Please see the appendix Figure 2The control and delivery system of this invention includes: a working gas source, a gas flow meter, a pulsed high-voltage generator, and an atomizer. The working gas may include at least one of helium, argon, nitrogen, and oxygen. One or more working gases flow through a mass flow controller (MFC), which can control the ratio of rare gas doped with oxygen and nitrogen, as well as the flow rate of the mixed working gas. A high-precision MFC can control the mixed gas flow rate within the range of 0.5 L / min to 10 L / min. The water vapor flow rate generated by the atomizer is 0.5–5 L / min. The mixed working gas is connected to a suspended electrode via a quick-connect interface. The input working gas is ionized by a square wave pulse with a voltage amplitude range of 6 kV-9 kV, a pulse width of 200-2000 ns, and a frequency range of 5 kHz-10 kHz. It undergoes primary ionization within a dielectric tube and secondary ionization at the end of the silicone tube of the suspended electrode before being discharged.

[0160] Figure 3 The invention demonstrates the composition of a treatment system comprising a nebulizer input module, a gas input module, a voltage input module, and a flow rate adjustment module. By precisely controlling the gas flux, a mixed working gas is introduced into the system to ensure that the plasma delivery medium environment has an appropriate gas composition and concentration. A multi-parameter adjustable high-voltage generator ionizes and generates a high concentration of active substances. Through precise control of the gas flux and discharge parameters, this system ensures the stability and controllability of the plasma jet at the distal end, thereby guaranteeing therapeutic efficacy.

[0161] Figure 4 The workflow of this invention is demonstrated.

[0162] First, turn on the nebulizer to generate stable water vapor, then introduce the working gas and adjust the gas flow rate. After stabilization, apply a pulsed high voltage to the external electrode to generate primary ionization in the dielectric tube. The voltage is then induced on the suspended copper wire through induction, inducing a secondary discharge at the distal silicone tube outlet. The resulting plasma jet acts on the target tissue or model to achieve the predetermined treatment or treatment effect.

[0163] Figure 5 This is a schematic diagram of plasma generation at a remote location. A high-voltage square wave pulse of 7000V-1us-10kHz is applied, along with helium gas at a flow rate of 4L / min. The image on the right demonstrates good safety; there is no electric shock upon touch.

[0164] Figure 6 The results show that the ozone concentration at the inlet was measured before and after atomization was turned on, and the results show that the ozone concentration can be significantly reduced after atomization is applied, demonstrating excellent ozone removal capability.

[0165] Figure 7The emission spectra of the tail jets under different glass dielectric tube thicknesses are presented. The results show that a 1 mm thick glass tube can produce more active products.

[0166] Figure 8 U251 cells were treated with a 7000V, 1µs, 10kHz pulsed square wave voltage. The working gas flow rate was 4L / min. After 5 minutes of treatment with 0.5L / min and without water vapor, Tunel staining was performed to induce apoptosis. The results showed that the application of water vapor effectively induced more tumor cell apoptosis.

[0167] Example 23:

[0168] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in Example 22, further simplifying the atomization method: replacing the external ultrasonic atomizer with a simple capillary jet atomization device, which can still generate sufficient water vapor atomization effect under the drive of airflow to enhance active products, while reducing the volume and energy consumption of the independent atomization module.

[0169] Example 24:

[0170] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 22 to 23. Further, the support structure is replaced: the 3D printed PLA bracket is replaced with a simple ceramic sleeve support, which can fix the copper wire conductor in the same way, further reducing the manufacturing process requirements and costs.

[0171] Example 25:

[0172] A distal discharge suspended electrode jet tube for atomizing enhanced active products, the main technical contents of which are described in any one of Examples 22 to 24. Furthermore, the gas path structure is simplified: the outer silicone coating layer is removed, and only a single-layer PTFE tube is used as the flow channel. Mixing is achieved by directly introducing atomized water vapor at the outlet. Although the atomization efficiency is slightly reduced, the overall structure is lighter and more suitable for portable applications.

[0173] Example 26:

[0174] A far-end discharge suspended electrode jet tube for atomizing enhanced active products, the main technical contents of which are described in any one of Examples 22 to 25. Further, the insulation material is replaced: the polyesterimide insulation layer on the surface of the copper wire is replaced with a fluoroplastic insulation layer (such as FEP coating), which can still effectively prevent electric shock, while improving high temperature resistance and extending the service life of the device.

[0175] Example 27:

[0176] A far-end discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 22 to 26. Further, the power module is replaced: the original high-voltage square wave pulse power supply is replaced with a frequency-modulated AC power supply (10–30kHz). Far-end plasma discharge can still be achieved by adjusting the frequency, simplifying the power control circuit and reducing energy consumption.

[0177] Example 28:

[0178] A distal discharge suspended electrode jet tube for atomizing and enhancing active products, the main technical contents of which are described in any one of Examples 22 to 27. Further, the atomizing water source is replaced: the atomizing device with an independent water inlet is replaced with a micro water vapor mixer shared with the gas channel, and a small amount of water vapor is directly introduced by the gas flow. Although the control precision is low, it can meet the needs of conventional sterilization or surface treatment and significantly simplify the structure.

Claims

1. A distal discharge suspended electrode jet tube for atomizing and enhancing active products, characterized in that, include: Dielectric tube (1), PLA support (2), ring electrode (3), flexible tube I (4), inductive conductor (5), flexible tube II (6); The dielectric tube (1) is a hollow columnar structure, with one end connected to an external gas generating device (11) and the other end connected to a flexible tube I (4) to form a working gas jet channel. The PLA bracket (2) is installed inside the dielectric tube (1) to fix the inductive conductor (5); The inductive conductor (5) extends from inside the dielectric tube (1) to the end of the flexible tube I (4), and the surface of the inductive conductor (5) is covered with an insulating layer; The ring electrode (3) surrounds the outer wall of the dielectric tube (1); The ring electrode (3) is electrically connected to the external pulse generator (9); The flexible tube II (6) is sleeved on the outside of the flexible tube I (4), and one end abuts against the dielectric tube (1). The end of the flexible tube II (6) extends beyond the end of the flexible tube I (4); The flexible tube II (6) is provided with an atomizing interface (7) on the side near the dielectric tube (1). The atomizing interface (7) is connected to the atomizer (8) to form an atomized liquid jet channel. Both the flexible tube I (4) and the flexible tube II (6) are made of biocompatible materials; When performing remote atomization discharge using the jet tube, the end of the flexible tube II (6) is placed in front of the object to be sprayed. The external gas generating device (11) inputs working gas, and the external pulse generator (9) generates an electrical signal on the ring electrode (3), which in turn generates electromagnetic induction coupling with the induction conductor (5). The induction conductor (5) generates an induced potential at the end of the flexible tube I (4). The working gas is ionized once in the dielectric tube (1) and ionized a second time at the end of the flexible tube I (4) to generate a plasma jet. The atomizer (8) inputs atomizing liquid, and the atomizing liquid combines with the plasma jet at the end of the flexible tube II (6) to output a plasma jet with enhanced active products, which acts on the object to be sprayed.

2. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, A gas flow meter (10) is also provided between the dielectric tube (1) and the external gas generating device (11). The gas flow meter (10) is used to control the input flow rate and ratio of the working gas; The input flow rate of the working gas is in the range of 0.5L / min-10L / min; The gas flow meter (10) includes a gas mass flow controller and a flow-limiting orifice plate.

3. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The dielectric tube (1) is made of materials including quartz, borosilicate glass, alumina ceramic, and high-silicon glass; The biocompatible materials include silicone and polytetrafluoroethylene.

4. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The insulating layer is made of materials including polyesterimide and fluoroplastics.

5. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The external pulse generator (9) includes a pulse power supply and a frequency-modulated AC power supply; The electrical signal generated by the external pulse generator (9) on the ring electrode (3) includes a square wave pulse voltage; The square wave pulse voltage has an amplitude range of 6kV-9kV, a pulse width range of 200ns-2000ns, and a frequency range of 5kHz-10kHz.

6. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The inductive conductor (5) includes a suspended metal wire electrode and a hollow needle electrode; The material used for the inductive conductor (5) includes copper.

7. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The length of the flexible tube (4) ranges from 0 to 2 m.

8. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The working gas includes at least one of helium, argon, nitrogen, and oxygen; The atomizing liquid includes water and physiological saline; The enhanced active product includes .

9. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The PLA bracket (2) includes a ceramic sleeve and a 3D printed bracket.

10. The distal discharge suspended electrode jet tube for atomizing enhanced active products according to claim 1, characterized in that, The atomizer (8) includes an ultrasonic atomizer, a capillary jet atomizing device, a micro-mist generator, a heating steam device, and a water-vapor mixer; The flow rate of the atomized liquid ranges from 0.5 L / min to 5 L / min.

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