Application of mesoporous silica prepared by using minerals as raw materials in hemostatic material

Abstract

The invention provides an application of mesoporous silica prepared by using minerals as raw materials in a hemostatic material, and a preparation method of the mesoporous silica comprises the following steps: (1) mixing the minerals, water and a grinding aid, and carrying out ultrafine grinding to obtain a primary material; (2) carrying out nanocrystallization grinding on the primary material to obtain nanoscale silicon-containing mineral slurry; (3) the nanoscale silicon-containing mineral slurry is dried and then subjected to acid purification treatment, and high-purity ore is obtained; (4) mixing the high-purity ore with a template agent, and calcining to obtain a mesoporous silica crude product; and (5) mixing and reacting the mesoporous silica crude product, water and an acid leaching agent to remove the template agent. The mesoporous silica prepared by the method disclosed by the invention has the advantages of no obvious cytotoxicity, no hemolysis phenomenon, good biocompatibility, high safety performance and high hemostasis efficiency.

Description

Technical Field

[0001] This invention belongs to the field of medical biomaterials technology, specifically providing the application of mesoporous silica prepared from minerals in hemostatic materials. Background Technology

[0002] Hemostasis is a core aspect of trauma treatment and surgery. Rapid and effective hemostasis can significantly reduce the incidence of hemorrhagic shock, decrease the risk of infection, and improve the success rate of treatment. Clinically commonly used inorganic hemostatic materials possess advantages such as high stability, excellent antibacterial properties, low preparation cost, and mild storage conditions, enabling their widespread application in emergency situations. Mesoporous silica, as a novel inorganic porous material, has become a research hotspot in the field of hemostatic materials due to its controllable pore structure and ultra-large specific surface area. However, current research indicates that existing pure mesoporous silica hemostatic materials still suffer from problems such as a single hemostatic pathway, low hemostatic efficiency, easy retention, and poor biocompatibility, thus restricting the development and application of high-performance mesoporous silica hemostatic materials. Summary of the Invention

[0003] This invention aims to at least partially address one of the technical problems in the prior art. Therefore, one object of this invention is to propose the application of mesoporous silica prepared from minerals in hemostatic materials, thereby solving the problems of low hemostatic efficiency and poor biocompatibility of existing mesoporous silica.

[0004] This invention proposes the application of mesoporous silica prepared from minerals in hemostatic materials, wherein the method for preparing the mesoporous silica includes: (1) The minerals, water and grinding aid are mixed and ultra-finely ground to obtain the primary material; (2) The primary material is nano-ground to obtain a nano-sized silicon-containing mineral slurry; (3) The nanoscale silicon-containing mineral slurry is dried and then subjected to acid purification treatment to obtain high-purity mineral; (4) The high-purity ore is mixed with the template agent and then calcined to obtain crude mesoporous silica; (5) The mesoporous silica crude product, water and acid leaching agent are mixed and reacted to remove the template agent.

[0005] The inventors discovered that the mesoporous silica prepared using the above method exhibits no significant cytotoxicity, no hemolysis, good biocompatibility, high safety, and high hemostatic efficiency. This innovative method utilizes silica-containing minerals as raw materials, first obtaining nano-sized silica particles through grinding and acid leaching, and then forming a mesoporous framework structure by adding a template agent and high-temperature calcination. This results in excellent biocompatibility and hemostatic properties. The method is simple, allows for mass production, and has low manufacturing costs.

[0006] In some embodiments of the present invention, in step (1), the SiO2 content in the mineral is ≥70%; In some embodiments of the present invention, the particle size of SiO2 in the mineral is 20nm-500nm. For example, the particle size is 20nm, 30nm, 50nm, 70nm, 90nm, 150nm, 200nm, 300nm, 400nm, 500nm, etc., or a range between any two of the above values.

[0007] In some embodiments of the present invention, the SiO2 in the mineral contains channels with a pore size of 5 nm to 200 nm. For example, the pore size is 5 nm, 10 nm, 30 nm, 50 nm, 80 nm, 100 nm, 150 nm, 200 nm, etc., or any range between any two of the above values.

[0008] In some embodiments of the present invention, in step (1), the mass ratio of the mineral, water and grinding aid is 100:(100~500):(0.5~5), preferably 100:(100~300):(1~2).

[0009] In some embodiments of the present invention, the grinding aid includes one of sodium polyacrylate and sodium hexametaphosphate.

[0010] In some embodiments of the present invention, the ultrafine grinding time is 0.5h-4h, preferably 1h-2h.

[0011] In some embodiments of the present invention, in step (2), the primary material is nano-milled to D. 90 <100nm.

[0012] In some embodiments of the present invention, the grinding media is selected from zirconia ceramic beads, diamond or lead oxide ceramic beads, preferably with a grinding media size of 0.03~0.4mm and a grinding media filling rate of 60%~80% in the grinding cavity, more preferably with a grinding media size of 0.03mm~0.2mm and a grinding media filling rate of 70%~80% in the grinding cavity.

[0013] In some embodiments of the present invention, step (3) includes: mixing the dried silicon powder with water and acid leaching agent for chemical leaching, then washing the leached slurry to neutral, and then drying and breaking it up.

[0014] In some embodiments of the present invention, the mass ratio of the silicon powder, the water and the acid leaching agent is 20:(20~160):(4~60), preferably 20:(60~160):(12~40).

[0015] In some embodiments of the present invention, the temperature of the chemical leaching is 60°C to 95°C, and the reaction time of the chemical leaching is 1h to 12h, preferably the temperature is 75°C to 95°C, and the reaction time is 6h to 12h.

[0016] In some embodiments of the present invention, the acid leaching agent includes a hydrochloric acid solution or a sulfuric acid solution, preferably the concentration of the hydrochloric acid solution is 30-37% and the concentration of the sulfuric acid solution is 50-65%.

[0017] In some embodiments of the present invention, in step (4), the mass ratio of the high-purity ore to the template agent is 10:(5~20), preferably 10:(10~15). For example, mass ratios of 10:5, 10:7, 10:9, 10:12, 10:15, 10:18, 10:20, etc., or any range between any two of the above values. Controlling the mass ratio of the high-purity ore to the template agent within the above range can effectively increase the specific surface area of ​​mesoporous silica, while controlling the average pore size between 10-20 nm.

[0018] In some embodiments of the present invention, the template agent is selected from at least one of α-Fe₂O₃, CaCO₃, and carbon black, preferably α-Fe₂O₃. The inventors have found that the template agent described above can be completely removed without affecting the formation of the mesoporous channel structure.

[0019] In some embodiments of the present invention, in step (4), the calcination temperature is 600℃~1000℃, preferably 600℃~800℃. For example, the calcination temperature is 600℃, 650℃, 700℃, 750℃, 800℃, 850℃, 900℃, 1000℃, etc., or a range between any two of the above values.

[0020] In some embodiments of the present invention, the calcination time is 0.5h to 3h, preferably 1h to 2h.

[0021] In some embodiments of the present invention, in step (5), the mass ratio of the crude mesoporous silica, the water and the acid leaching agent is 20:(20~160):(4~60), preferably 20:(60~160):(12~40). In some embodiments of the present invention, in step (5), the temperature of the mixing reaction is 75°C to 95°C, the time of the mixing reaction is 1h to 12h, preferably the temperature is 85°C to 95°C, and the reaction time is 1h to 6h; In some embodiments of the present invention, in step (5), the acid leaching agent includes a hydrochloric acid solution or a sulfuric acid solution, preferably a hydrochloric acid solution.

[0022] In some embodiments of the present invention, in step (5), the acid leaching agent includes a hydrochloric acid solution or a sulfuric acid solution, more preferably a hydrochloric acid solution.

[0023] Furthermore, the concentration of the hydrochloric acid solution is 30-37%, and the concentration of the sulfuric acid solution is 50-65%.

[0024] In some embodiments of the present invention, the specific surface area of ​​the mesoporous silica is 10³ m². 2 / g, with an average pore size of 12nm.

[0025] Compared with the prior art, the present invention can achieve at least one of the following beneficial effects: This invention innovatively utilizes silica-containing minerals as raw materials. First, nano-sized silica particles are obtained through grinding and acid leaching. Then, a template agent is added and the particles are calcined at high temperature to form a mesoporous framework structure. The resulting mesoporous silica has excellent biocompatibility and hemostatic properties. Furthermore, the method used in this invention is simple, can be mass-produced, and has low manufacturing costs. Attached Figure Description

[0026] Figure 1 The images shown are scanning electron microscope (SEM) images of the mineral raw materials used in the embodiments of the present invention. Figure 2 This is a scanning electron microscope image of the mesoporous silica in Embodiment 2 of the present invention. Detailed Implementation

[0027] Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of this invention. The invention will now be described with reference to specific embodiments. It should be noted that these embodiments are merely descriptive and do not limit the invention in any way.

[0028] The mineral raw materials used in this embodiment of the invention underwent mineralogical quantitative analysis using X-ray diffraction (XRD), which revealed that they contained quartz, pyrite, kaolinite, and mica, with a silica content of 77%. Figure 1 Scanning electron microscopy (SEM) analysis revealed that the quartz contained therein was nanoscale, with a particle size of 200-300 nm, and also contained nanoscale pore structures with an average pore size of 21 nm.

[0029] Example 1 This embodiment provides a method for preparing mesoporous silica, including the following steps: (1) The silicon-containing mineral powder (D 90 =54.10μm) was added to a certain amount of water, and sodium hexametaphosphate was added as a grinding aid. The ratio of mineral powder:water:grinding aid = 100:300:1, and ultrafine grinding was carried out for 2 hours.

[0030] (2) Nano-grinding of the mineral powder slurry obtained in step (1): Add 0.1 mm diameter diamond grinding media to the nano-bead mill with a filling rate of 75%, and pump the ultra-finely ground slurry into the storage tank of the bead mill. Grind the material repeatedly in the bead mill for 12 hours until D 90 <100nm, the slurry is pumped out to obtain nanoscale mineral slurry, which is then dried and dispersed to obtain nanoscale mineral particles.

[0031] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:70:90. The reaction temperature was 95℃ and the reaction time was 12h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0032] (4) The high-purity silicon powder obtained in step (3) is mixed with a certain amount of template agent (α-Fe2O3) in a mass ratio of silicon powder: template agent = 10:15. The mixture is then placed in a muffle furnace for calcination at a temperature of 800℃ for 1 hour to obtain mesoporous silica material.

[0033] (5) After dispersing the mesoporous silica material obtained in step (4), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 8h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0034] The obtained mesoporous silica hemostatic material has a specific surface area of ​​67 m². 2 / g, with an average pore size of 26nm.

[0035] Example 2 This embodiment provides a method for preparing mesoporous silica, including the following steps: (1) Same as Example 1.

[0036] (2) Same as in Example 1.

[0037] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:55:65. The reaction temperature was 90℃ and the reaction time was 12h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0038] (4) The high-purity silicon powder obtained in step (3) is mixed with a certain amount of template agent (α-Fe2O3) in a mass ratio of silicon powder: template agent = 10:10. The mixture is then placed in a muffle furnace for calcination at a temperature of 600℃ for 1.5h to obtain mesoporous silica material.

[0039] (5) After dispersing the mesoporous silica material obtained in step (4), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 6h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0040] For reference, please refer to the electron micrograph of the obtained mesoporous silica. Figure 2 The obtained mesoporous silica hemostatic material has a specific surface area of ​​10³ m². 2 / g, with an average pore size of 12nm.

[0041] Example 3 This embodiment provides a method for preparing mesoporous silica, including the following steps: (1) Same as Example 1.

[0042] (2) Same as in Example 1.

[0043] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:55:65. The reaction temperature was 90℃ and the reaction time was 12h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0044] (4) The high-purity silicon powder obtained in step (3) is mixed with a certain amount of template agent (α-Fe2O3) in a mass ratio of silicon powder: template agent = 10:5. The mixture is then placed in a muffle furnace for calcination at a temperature of 800℃ for 2 hours to obtain mesoporous silica material.

[0045] (5) After dispersing the mesoporous silica material obtained in step (4), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 6h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0046] The obtained mesoporous silica hemostatic material has a specific surface area of ​​38 m². 2 / g, with an average pore size of 22nm.

[0047] Example 4 This embodiment provides a method for preparing mesoporous silica, including the following steps: (1) Same as Example 1.

[0048] (2) Same as in Example 1.

[0049] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:55:65. The reaction temperature was 90℃ and the reaction time was 12h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0050] (4) The high-purity silicon powder obtained in step (3) is mixed with a certain amount of template agent (CaCO3) in a mass ratio of silicon powder: template agent = 10:10. Then the mixture is placed in a muffle furnace for calcination at a temperature of 600℃ for 1 hour to obtain mesoporous silica material.

[0051] (5) After dispersing the mesoporous silica material obtained in step (4), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 6h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0052] The obtained mesoporous silica hemostatic material has a specific surface area of ​​73 m². 2 / g, with an average pore size of 18nm.

[0053] Example 5 (1) Same as Example 1.

[0054] (2) Same as in Example 1.

[0055] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:55:65. The reaction temperature was 90℃ and the reaction time was 12h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0056] (4) The high-purity silicon powder obtained in step (3) is mixed with a certain amount of template agent (carbon black) in a mass ratio of silicon powder: template agent = 10:10. Then the mixture is placed in a muffle furnace for calcination at a temperature of 600℃ for 1 hour and then broken up to obtain mesoporous silica hemostatic material.

[0057] (5) After dispersing the mesoporous silica material obtained in step (4), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 6h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0058] The obtained mesoporous silica hemostatic material has a specific surface area of ​​55 m². 2 / g, with an average pore size of 24nm.

[0059] Comparative Example 1 This comparative example provides a method for preparing mesoporous silica, comprising the following steps: (1) Same as Example 1.

[0060] (2) Same as in Example 1.

[0061] (3) The nano-sized mineral particles obtained in step (2) were added to a certain amount of water and chemically leached and purified using an acid leaching agent (hydrochloric acid solution, concentration 37%). The mass ratio of mineral powder:water:acid leaching agent was 20:55:65. The reaction temperature was 85℃ and the reaction time was 8h. The purified slurry was centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain high-purity silicon powder.

[0062] (4) The high-purity silicon powder obtained in step (3) is placed in a muffle furnace and calcined at 700°C for 1 hour to obtain mesoporous silica hemostatic material.

[0063] The obtained mesoporous silica hemostatic material has a specific surface area of ​​42 m². 2 / g, with an average pore size of 6nm.

[0064] Comparative Example 2 The difference between Comparative Example 2 and Example 2 is that, in step 4), fumed silica is used instead of silicon carbide.

[0065] This comparative example provides a method for preparing mesoporous silica, comprising the following steps: (1) Fumed silica (CAS No.: 112945-52-5) was mixed with a certain amount of template agent (α-Fe2O3) in a mass ratio of silica powder: template agent = 10:10. The mixture was then placed in a muffle furnace and calcined at a temperature of 600℃ for 1.5h to obtain mesoporous silica material.

[0066] (2) After dispersing the mesoporous silica material obtained in step (1), add it to a certain amount of water and use an acid leaching agent (hydrochloric acid solution, concentration of 37%) to remove the template agent. The mass ratio of mesoporous silica:water:acid leaching agent = 20:36:44, the reaction temperature is 85℃, and the reaction time is 6h. After removing the template agent, the slurry is centrifuged and washed with deionized water until neutral, then dried and dispersed to obtain the mesoporous silica hemostatic material.

[0067] The obtained mesoporous silica hemostatic material has a specific surface area of ​​216 m². 2 / g, with an average pore size of 16nm.

[0068] The performance of the mesoporous silica in the examples and comparative examples was tested, as follows: (1) Blood compatibility test: Preparation of Red Blood Cell Suspension: Take 1 ml of fresh anticoagulated rabbit blood and mix it with 4 ml of PBS buffer. Centrifuge (1500 r / min, 10 min). Use a pipette to aspirate the supernatant plasma layer and the white blood cell layer. Add PBS buffer, mix well, and centrifuge again to further wash the red blood cells. Dilute the heaped red blood cells with PBS to a 5% red blood cell suspension.

[0069] Hemolysis rate test: 1 mg of mesoporous silica hemostatic material was uniformly dispersed in 10 ml of PBS. 0.2 ml of red blood cell suspension was added to 0.8 ml of PBS sample mixture. The negative control group consisted of 0.2 ml of red blood cell suspension added to 0.8 ml of PBS, and the positive control group consisted of 0.2 ml of red blood cell suspension added to 0.8 ml of deionized water. All mixtures were incubated in a 37°C water bath for 60 min, and then centrifuged (3000 r / min, 5 min) to obtain the supernatant. The absorbance of the supernatant was measured at 540 nm using a spectrophotometer. PBS and deionized water were used as the negative and positive control groups, respectively.

[0070] Hemolysis rate (%) = (Sample absorption - Negative control absorption) / (Positive control absorption - Negative control absorption) × 100% The lower the hemolysis rate, the higher the blood compatibility of the material; a hemolysis rate of less than 5% is considered to indicate that no hemolysis has occurred.

[0071] (2) In vitro coagulation test 10 mg of mesoporous silica hemostatic material sample was added to a 5 mL glass tube and incubated in a water bath at 37°C for 5 min. No substance was added to the control group. Then, 1 mL of fresh anticoagulated rabbit blood was mixed with the sample and incubated in a water bath at 37°C for 3 min. Next, 500 µL of 0.025 mol / L CaCl2 aqueous solution was added to the test tube to initiate clotting. The test tube was removed from the water bath and inverted every 5 seconds until the blood in the test tube stopped flowing (inverting up to 180°). The clotting time (s) was recorded.

[0072] The specific test results are shown in Table 1 below.

[0073] Table 1

[0074] As can be seen from the data in Table 1, compared with the comparative example, the mesoporous silica of the present invention has a shorter in vitro coagulation time and can effectively reduce the hemolysis rate, thus improving the biocompatibility of the mesoporous silica. Although the mesoporous silica prepared in Comparative Example 2 has a large comparative area, its in vitro coagulation time is still relatively long, and its coagulation performance is poor. This shows that the mesoporous silica prepared by the method of the present invention can simultaneously take into account both coagulation and biocompatibility.

[0075] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. Use of mesoporous silica prepared from a mineral as a raw material in a hemostatic material, characterized in that, The preparation method of the mesoporous silica comprises: (1) mixing minerals, water and grinding aids for superfine grinding to obtain primary materials; (2) nano-grinding the primary materials to obtain a nano-sized silicon-containing mineral slurry; (3) drying the nano-sized silicon-containing mineral slurry and then performing acid purification treatment to obtain high-purity minerals; (4) mixing the high-purity minerals with a template agent and then calcining to obtain mesoporous silica crude products; (5) mixing the mesoporous silica crude products, water and an acid leaching agent to remove the template agent.

2. Use according to claim 1, characterized in that, In step (1), the content of SiO2 in the minerals is ≥70%; And / or, the particle size of SiO2 in the minerals is 20-500 nm; And / or, the SiO2 in the minerals has pores with a pore size of 5-200 nm.

3. Use according to claim 1, characterized in that, In step (1), the mass ratio of the minerals, water and grinding aids is 100:(100-500):(0.5-5), preferably 100:(100-300):(1-2); And / or, the grinding aids comprise one of sodium polyacrylate and sodium hexametaphosphate; And / or, the superfine grinding time is 0.5-4 h, preferably 1-2 h.

4. Use according to any one of claims 1 to 3, characterized in that, In step (2), the primary material is nanomilled to a D 90 <100 nm; And / or, the grinding medium is selected from zirconia ceramic beads, diamond or lead oxide ceramic beads, preferably the size of the grinding medium is 0.03-0.4 mm, and the filling rate of the grinding medium in the grinding cavity is 60%-80%, more preferably the size of the grinding medium is 0.03-0.2 mm, and the filling rate of the grinding medium in the grinding cavity is 70%-80%.

5. Use according to any one of claims 1 to 3, characterized in that, In step (3), the acid purification treatment comprises: mixing the dried silicon powder with water and an acid leaching agent for chemical leaching, then washing the leached slurry to neutral, and then drying and breaking up.

6. Use according to claim 5, characterized in that, The mass ratio of the silicon powder, the water and the acid leaching agent is 20:(20-160):(4-60), preferably 20:(60-160):(12-40); And / or, the chemical leaching temperature is 60-95°C, and the chemical leaching reaction time is 1-12 h, preferably the temperature is 75-95°C, and the reaction time is 6-12 h; And / or, the acid leaching agent comprises a hydrochloric acid solution or a sulfuric acid solution, preferably the concentration of the hydrochloric acid solution is 30-37%, and the concentration of the sulfuric acid solution is 50-65%.

7. Use according to any one of claims 1 to 3, characterized in that, In step (4), the mass ratio of the high-purity minerals to the template agent is 10:(5-20), preferably 10:(10-15); And / or, the template agent is selected from at least one of α-Fe2O3, CaCO3 and carbon black, preferably α-Fe2O3.

8. Use according to any one of claims 1 to 3, characterized in that, In step (4), the calcination temperature is 600-1000°C, preferably 600-800°C; And / or, the calcination time is 0.5-3 h, preferably 1-2 h.

9. Use according to any one of claims 1 to 3, characterized in that, In step (5), the mass ratio of the mesoporous silica crude products, the water and the acid leaching agent is 20:(20-160):(4-60), preferably 20:(60-160):(12-40); And / or, the temperature of the mixing reaction is 75-95℃, and the time of the mixing reaction is 1-12h, preferably the temperature is 85-95℃, and the reaction time is 1-6h; And / or, the acid pickling agent comprises a hydrochloric acid solution or a sulfuric acid solution, preferably a hydrochloric acid solution.

10. Use according to any one of claims 1 to 3, characterized in that, The mesoporous silica has a specific surface area of 43 m 2 / g-113 m 2 / g, and an average pore diameter of 3 nm-24 nm.

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