Pulse and ultrasonic energy time sequence synergistic drug delivery method and system
By using a time-sequential synergistic drug delivery method combining pulsed and ultrasonic energy, the problem of balancing drug concentration dilution and heat dissipation was solved, achieving highly efficient drug penetration and thrombolysis, and improving drug utilization and system heat dissipation capacity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-01-14
- Publication Date
- 2026-03-10
AI Technical Summary
Existing ultrasonic thrombolysis systems suffer from low drug concentration dilution and penetration efficiency, fail to effectively utilize the ultrasonic cavitation effect, and lack coordinated control of cooling and drug delivery timing, making it difficult to balance drug efficacy and system heat dissipation.
A time-sequential drug delivery method combining pulsed and ultrasonic energy is employed. By alternating pauses in drug injection and coolant delivery, combined with ultrasonic operation, periodic high-concentration targeted drug release and system heat dissipation are achieved. This includes cyclical steps of pure coolant flushing, pure drug pulse injection, and coolant flushing and cooling.
It significantly improves drug utilization and thrombolytic effect, enhances drug penetration by utilizing ultrasonic cavitation effect, and ensures system heat dissipation requirements, thereby achieving efficient drug release and therapeutic effect.
Smart Images
Figure CN121622183A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of medical technology, and specifically relates to a method and system for the time-sequential coordinated delivery of pulsed and ultrasonic energy. Background Technology
[0002] Ultrasonic thrombolysis is often used in conjunction with medication to enhance thrombolysis. However, existing ultrasonic thrombolysis systems mostly employ a continuous mixing and delivery method of medication and coolant, resulting in drug dilution, low local concentrations, and the inability of the thrombus surface to be periodically exposed to a high-concentration drug environment. This reduces drug penetration efficiency and thrombolytic effect. Furthermore, current technologies fail to effectively utilize the peak period of ultrasonic cavitation effect for drug release to promote penetration, and lack coordinated control over the timing of cooling and drug administration, making it difficult to balance system heat dissipation and drug efficacy. Summary of the Invention
[0003] In order to overcome the shortcomings of the prior art, the present invention provides a method and system for the time-sequential coordinated delivery of pulse and ultrasonic energy.
[0004] This invention is achieved through the following technical solution: A method for time-sequential drug delivery using pulsed and ultrasonic energy, characterized by the following steps: 1. Stop the injection and rinse with coolant for 2-4 seconds. 1. Suspend the coolant delivery and allow the agent to be sprayed for 0.5-1.5 seconds, while the ultrasonic treatment continues. 1. Pause the injection of the drug and re-inject the coolant for 2-4 seconds; Repeat steps (1), (2) and (3) until the task is completed.
[0005] Preferably, in step (1), the duration is 3 seconds.
[0006] Preferably, in step (2), the duration is 1 second.
[0007] Preferably, in step (2), the coolant flow rate is adjusted to the minimum.
[0008] Preferably, in step (3), the duration is 3 seconds.
[0009] A pulsed and ultrasonic energy time-sequential drug delivery system includes an ultrasonic catheter, characterized in that: the ultrasonic catheter is connected to a main unit, and the ultrasonic catheter is also connected to a drug tube and a coolant tube, the drug tube is connected to an injection pump, and the coolant tube is connected to a cooling pump.
[0010] The ultrasonic catheter is connected to the main unit via a Luer interface, which is connected to the drug tube and the coolant tube, respectively.
[0011] The injection pump and the cooling pump are respectively connected to the main unit.
[0012] The beneficial effects of this invention are: by using pulsed drug delivery and time-sequential synergistic control, periodic targeted release of high-concentration drugs is achieved, significantly improving drug utilization and thrombolytic effect, and the ultrasonic cavitation effect is used to enhance drug penetration while ensuring the system's heat dissipation requirements. Attached Figure Description
[0013] The invention will now be further described with reference to the accompanying drawings.
[0014] Appendix Figure 1 This is a schematic diagram of the structure of the present invention; Appendix Figure 2 This is a schematic diagram of the workflow of the present invention; In the diagram, 1 is the ultrasonic catheter, 2 is the main unit, 3 is the drug tubing, 4 is the coolant tubing, 5 is the injection pump, 6 is the cooling pump, and 7 is the Luer connector. Detailed Implementation
[0015] The attached figure illustrates a specific embodiment of the present invention. This embodiment includes an ultrasonic catheter 1, which is connected to a main unit 2. The ultrasonic catheter 1 is also connected to a drug tube 3 and a coolant tube 4. The drug tube 3 is connected to an injection pump 5, and the coolant tube 4 is connected to a cooling pump 6.
[0016] The ultrasonic catheter 1 is connected to the main unit 2 via a Luer connector 7, which is then connected to the drug tubing 3 and the coolant tubing 4, respectively. The injection pump 5 and the cooling pump 6 are connected to the main unit 2, respectively.
[0017] Using the pulse and ultrasound energy timing-coordinated drug delivery method of the present invention, the controller of the host 2 executes the following cyclic steps: Pure coolant flushing phase: Pause the infusion pump 5 and flush the treatment window with coolant only for 2 seconds; Pure drug pulse injection phase: pause cooling pump 6 and start injection pump 5 at the same time to spray a quantitative amount of pure drug onto the thrombus surface at a high flow rate for 0.5 seconds. During this time, ultrasound continues to work. Coolant flushing and cooling phase: Restart cooling pump 6, flush residual drugs at high speed and cool ultrasound catheter 1 for 2 seconds; The above three stages form a cycle that is repeated throughout the process until completion.
[0018] Using the pulse and ultrasound energy timing-coordinated drug delivery method of the present invention, the controller of the host 2 executes the following cyclic steps: Pure coolant flushing phase: Pause the infusion pump 5 and flush the treatment window with coolant only for 3 seconds; Pure drug pulse injection phase: pause cooling pump 6 and start injection pump 5 to spray a quantitative amount of pure drug onto the thrombus surface at a high flow rate for 1 second. During this time, ultrasound continues to work. Coolant flushing and cooling phase: Restart cooling pump 6 to flush residual drugs at high speed and cool ultrasound catheter 1 for 3 seconds; The above three stages form a cycle that is repeated throughout the process until completion.
[0019] Using the pulse and ultrasound energy timing-coordinated drug delivery method of the present invention, the controller of the host 2 executes the following cyclic steps: Pure coolant flushing phase: Pause the infusion pump 5 and flush the treatment window with coolant only for 3 seconds; Pure drug pulse injection phase: Adjust the cooling pump 6 to the lowest flow rate and start the injection pump 5 at the same time to spray a quantitative amount of pure drug onto the thrombus surface at a higher flow rate for 1 second. During this time, the ultrasound continues to work. Coolant flushing and cooling phase: Restart cooling pump 6 to flush residual drugs at high speed and cool ultrasound catheter 1 for 3 seconds; The above three stages form a cycle that is repeated throughout the process until completion.
[0020] Using the pulse and ultrasound energy timing-coordinated drug delivery method of the present invention, the controller of the host 2 executes the following cyclic steps: Pure coolant flushing phase: Pause the infusion pump 5 and flush the treatment window with coolant only for 4 seconds; Pure drug pulse injection phase: pause cooling pump 6 and start injection pump 5 at the same time to spray a fixed amount of pure drug onto the thrombus surface at a high flow rate for 1.5 seconds. During this time, ultrasound continues to work. Coolant flushing and cooling phase: Restart cooling pump 6, flush residual drugs at high speed and cool ultrasound catheter 1 for 4 seconds; The above three stages form a cycle that is repeated throughout the process until completion.
[0021] The pulsed and ultrasonic energy-based time-sequential drug delivery method and system of this invention achieves periodic targeted release of high-concentration drugs by cyclically executing a sequence of "pure coolant flushing - pure drug pulse injection - pure coolant flushing," while utilizing the ultrasonic cavitation effect to enhance drug efficacy and ensure system heat dissipation. The system has a simple structure, clear control logic, and is easy to implement and promote. It is adaptable to various drug types and treatment scenarios, offering high flexibility.
Claims
1. A method of pulse and ultrasonic energy chronomodulated administration, characterized in that: The method comprises the following steps: (1) pause the injection of the medicine, only flush with the cooling liquid, last for 2-4 seconds; (2) pause the delivery of the cooling liquid, spray the medicine, last for 0.5-1.5 seconds, and meanwhile the ultrasonic device keeps working; (3) pause the injection of the medicine, input the cooling liquid again, last for 2-4 seconds; (4) repeat steps (1), (2) and (3) until the completion.
2. The method of pulsed and ultrasonic energy chronomphrization according to claim 1, wherein: In step (1), last for 3 seconds.
3. The method of pulsed and ultrasonic energy chronomphrization according to claim 1, wherein: In step (2), last for 1 second.
4. The method of pulsed and ultrasonic energy chronomphrization according to claim 1, wherein: In step (2), adjust the cooling liquid to the lowest flow rate.
5. The method of pulsed and ultrasonic energy chronomphrization according to claim 1, wherein: In step (3), last for 3 seconds.
6. A pulse and ultrasonic energy chronomodulated administration system comprising an ultrasonic catheter (1), characterized in that: The ultrasonic catheter (1) is connected with the main machine (2), and the ultrasonic catheter (1) is also connected with the medicine pipe (3) and the cooling liquid pipe (4) at the same time, the medicine pipe (3) is connected with the injection pump (5), and the cooling liquid pipe (4) is connected with the cooling pump (6).
7. The pulse and ultrasonic energy chronomphed administration system of claim 6 wherein: The ultrasonic catheter (1) is connected with the main machine (2) through the luer connector (7), and the luer connector (7) is connected with the medicine pipe (3) and the cooling liquid pipe (4) respectively.
8. The pulse and ultrasonic energy chronomphrized delivery system of claim 6 wherein: The injection pump (5) and the cooling pump (6) are connected with the main machine (2) respectively.