Skin bionic powder as well as preparation method and application thereof

Abstract

The invention discloses skin bionic powder as well as a preparation method and application thereof. The skin bionic powder comprises inorganic powder located in the middle, wrapping the outer side of the inorganic powder with a first wrapping structure layer; and the outer side of the first wrapping structure layer is wrapped with a second wrapping structure layer. According to the invention, a double-layer coating structure of the water absorbing layer and the phospholipid membrane is creatively adopted, and the skin environment is doubly simulated through a bionic structure from a simple water replenishing function, so that the powder has good biological affinity.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of biomimetic raw materials and new materials, in particular to a skin biomimetic powder, a preparation method and application thereof. BACKGROUND

[0002] Titanium dioxide, iron oxide and other inorganic powders are commonly used colorants and physical sunscreens in the prior art.

[0003] However, there are still challenges in application, such as skin adhesion and fine powder texture, which ultimately stem from the following defects when the powder is applied to the skin surface for coverage:

[0004] 1. Poor skin adhesion of inorganic powder in the prior art: the surface of inorganic powder has high-energy hydroxyl groups, which are incompatible with skin sebum (mainly composed of squalene, triglyceride, fatty acid, etc.), easily causing "powder feeling" and "powder floating" phenomena, and unnatural makeup effect.

[0005] 2. Inorganic powder in the prior art is prone to agglomeration: high surface energy leads to mutual attraction between particles, and the smaller the particle size, the higher the surface energy, making it difficult to disperse uniformly in the formula, affecting product stability.

[0006] 3. Inorganic powder in the prior art has catalytic activity: titanium dioxide, zinc oxide and other materials have photocatalytic activity and may produce reactive oxygen under ultraviolet light, causing potential oxidative stress to the skin.

[0007] In order to overcome the above-mentioned defects of the prior art, some manufacturers have carried out surface treatment on inorganic powder in the prior art, such as silicon coating, aluminum coating, silanization and other surface treatment methods, which only improve the dispersibility and catalytic activity of the powder from a physical and chemical point of view, but the biocompatibility is still defective.

[0008] It cannot comprehensively provide a moist feeling, excellent skin adhesion and biomimetic cell membrane affinity, resulting in poor adhesion and compatibility. SUMMARY

[0009] In order to overcome the above-mentioned defects of the prior art, the purpose of the present application is to provide a skin biomimetic powder, a preparation method and application thereof.

[0010] Unlike the prior art, in order to fundamentally improve the compatibility of the powder and the skin, the present application not only simulates the skin components in terms of composition, but also simulates the cell structure in terms of structure, providing a skin biomimetic powder structure with improved adhesion and compatibility.

[0011] In order to achieve the purpose of the present application, the technical solutions adopted are as follows:

[0012] A skin biomimetic powder, comprising:

[0013] an inorganic powder in the middle

[0014] a first coating structure layer is coated outside the inorganic powder;

[0015] a second coating structure layer is coated outside the first coating structure layer;

[0016] the inorganic powder is any one or a mixture of more than one of titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, mica, talc, silica, boron nitride, ultramarine, chromium green;

[0017] the first coating structure layer is a humectant,

[0018] the humectant is any one or a mixture of more than one of a high-molecular polysaccharide humectant, a small-molecular polyol humectant, a large-molecular polyol humectant, a high-molecular polypeptide humectant, an amide compound humectant;

[0019] the second coating structure layer is any one or more than one of a phospholipid or a phospholipid derivative.

[0020] in a preferred embodiment of the present application,

[0021] the high-molecular polysaccharide humectant is sodium hyaluronate;

[0022] the small-molecular polyol humectant is glycerol;

[0023] the large-molecular polyol humectant is polyglycerol;

[0024] the high-molecular polypeptide humectant is polyglutamic acid;

[0025] the amide compound humectant is ceramide.

[0026] in a preferred embodiment of the present application,

[0027] the phospholipid or the phospholipid derivative is any one or more than one of lecithin, hydrogenated lecithin, phosphatidylserine.

[0028] A preparation method of a skin biomimetic powder, comprising:

[0029] a humectant is dissolved in deionized water or ethanol until clear, and the obtained solution B is added dropwise to a suspension A formed by dispersing the inorganic powder in water, and then a solution C obtained by dissolving the phospholipid or the phospholipid derivative in deionized water until clear is added dropwise into the foregoing product,

[0030] slow stirring is performed to form a stable double-layer structure, the pH is controlled to be 5-7, and the reaction time is 1-2 h, after which the reaction is ended, the product is filtered, washed with water, and dried to obtain the skin biomimetic powder structure;

[0031] The mass ratio of the inorganic powder, the moisturizing agent, the phospholipid or the phospholipid derivative in the skin biomimetic powder structure is 85-99.9:0.1-5:1-10.

[0032] A preparation method of a skin biomimetic powder, specifically comprising the following steps:

[0033] In the first step, the inorganic powder is dispersed in water for sand mill dispersion, filtration, and filtration to form a suspension A, which is heated to 50-60℃ while stirring;

[0034] In the second step, the moisturizing agent is dissolved in deionized water to form a clear solution B;

[0035] In the third step, the solution B is added dropwise to the suspension A, the pH is controlled to be 5-7, the temperature is controlled to be 50-60℃, and the reaction is carried out for 1-3 hours;

[0036] In the fourth step, the phospholipid or the phospholipid derivative is dissolved in deionized water to form a clear solution C;

[0037] In the fifth step, the solution C is added dropwise to the product of the third step, and slow stirring is carried out to form a stable bilayer structure, the pH is controlled to be 5-7, and the reaction is carried out for 1-2 hours. After the reaction is completed, the skin biomimetic powder structure is obtained by filtration, water washing and drying;

[0038] The mass ratio of the inorganic powder, the moisturizing agent, the phospholipid or the phospholipid derivative in the skin biomimetic powder structure is 85-99.9:0.1-5:1-10.

[0039] In a preferred embodiment of the present application, the sand mill dispersion in the first step is carried out at a rotation speed of 2000-3000 rpm for 10-40 minutes by using zirconium beads. The zirconium beads are preferably zirconium beads with a size of 0.3-0.4 mm.

[0040] The inorganic powder is preferably any one or more of titanium dioxide particles with a size of 100-200 nm, iron oxide red particles with a size of 1-3 μm, titanium dioxide particles with a size of 200-300 nm, iron oxide yellow, iron oxide red, iron oxide black, mica, synthetic fluorphlogopite, boron nitride, ultramarine blue, and chromium green.

[0041] In a preferred embodiment of the present application, the dissolution temperature in the second step is room temperature or 50-60℃.

[0042] In a preferred embodiment of the present application, the dissolution temperature in the fourth step is 50-60℃.

[0043] In a preferred embodiment of the present application, the slow stirring in the fifth step is carried out at a stirring speed of not higher than 300 rpm.

[0044] Use of a skin biomimetic powder, the use being for the manufacture of a covering or concealing of the surface of the skin.

[0045] The present application has the following advantages:

[0046] 1. Biomimetic structure design: innovatively adopt double-layer coating structure of water-absorbing layer + phospholipid film, from simple moisturizing function to double-simulate skin environment through biomimetic structure, so that the powder has good biological affinity. Applied to foundation, a dense powder film with skin barrier structure can be constructed to form a biomimetic skin layer.

[0047] 2. Instant water moistening feeling: the water-absorbing material in the inner layer can effectively combine water molecules, release water moistening feeling at the moment of applying the formula, improve the dry and rough touch of traditional powder, and improve the use experience.

[0048] 3. Excellent skin adhesion: the outermost phospholipid layer simulates the cell membrane structure, which is highly similar to the cell membrane composition of the stratum corneum, can promote the close adhesion of the powder on the skin, make the makeup effect more comfortable, durable and natural, and reduce the floating powder.

[0049] 4. Stability and compatibility: the double-layer coating structure improves the dispersion stability of colorants in oil or water phase matrix. The amphiphilic property of the phospholipid layer makes it compatible with various emulsification systems.

[0050] 5. High safety: the coating materials used are skin-friendly ingredients, which further reduces the potential irritation and is suitable for the development of sensitive skin covering agents.

[0051] 6. Wide applicability: this method can be applied to most skin covering agent powders, including but not limited to titanium dioxide, zinc oxide, iron oxide, mica, talc, boron nitride, silica, ultramarine, chromium green, etc., providing a universal solution for the entire industry. BRIEF DESCRIPTION OF DRAWINGS

[0052] Figure 1 Transmission electron microscopy of the skin biomimetic powder structure of the present application, Example 1 Figure 1 (a) and high-resolution transmission electron microscopy Figure 1 (b).

[0053] Figure 2 Comparison chart before and after biomimetic wrapping.

[0054] Figure 3 Analysis spectrum chart after biomimetic wrapping.

[0055] Figure 4 EDX energy spectrum analysis chart of corresponding elements after biomimetic wrapping.

[0056] Figure 5 Comparison chart of blue light protection effect of prior art and Example 1.

[0057] Figure 6 Figure 1 is a graph showing the red light transmission effect of the blank control, Example 1 and the prior art.

[0058] Figure 7 Figure 2 is a graph showing the fineness test of the comparative example and the example.

[0059] Figure 8 Figure 3 is a micrograph showing the before and after makeup effect comparison of the comparative example and the example.

[0060] Figure 9 Figure 4 is a graph showing the before and after scratch comparison of the comparative example and the example.

[0061] Figure 10 Figure 5 is a graph showing the moisture and oil score comparison of the comparative example and the example before and after makeup.

[0062] Figure 11 Figure 6 is a graph showing the color difference trend comparison of the comparative example and the example over time.

[0063] Figure 12 Figure 7 is a radar chart of Application Test 1. DETAILED DESCRIPTION

[0064] In order to make the purpose, technical solutions and advantages of the present application clearer and more apparent, the present application will be further described in detail below with the aid of the accompanying drawings and examples. However, it should be understood that the specific examples described herein are merely intended to explain the present application and are not intended to limit the scope of the present application. In addition, in the following structures, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concept of the present application.

[0065] The inventors of the present application made the following technical improvements after a large number of experiments:

[0066] The core inorganic powder is subjected to double-layer biomimetic coating: first, a moisture absorption and water locking layer simulating cytoplasmic hydration is constructed, which mainly functions to capture and lock water, providing a "water explosion" feeling when contacting the skin, and relieving the dryness of the colorant itself.

[0067] Further, on this basis, a biological affinity outer coating layer simulating the interface characteristics of the cell membrane is constructed, which is a lipid bilayer, coated on the outer surface of the inner coating layer. It contains at least one of lecithin, hydrogenated lecithin and phosphatidylserine. This layer simulates the phospholipid bilayer structure of human cell membranes, with its hydrophilic end combined with the inner water locking layer and its hydrophobic end outwardly affined with the skin sebum membrane, thereby greatly improving the adhesion, spreadability and biocompatibility of the colorant on the skin, achieving the effect of "biomimetic skin adhesion".

[0068] The skin biomimetic powder structure of the present application changes the powder from a single coloring function to a multifunctional powder structure integrating instant moisturizing and long-term skin-friendly functions. Thus, the foundation can form a highly skin-concealed biomimetic powder film, achieving a natural makeup effect like a second layer of skin.

[0069] The present application adopts a step-by-step biomimetic coating strategy: in the first step, a layer of moisture-absorbing and water-locking components is constructed on the surface of the powder core to simulate the moisturizing microenvironment of the cytoplasm, thereby solving the problem of dryness and roughness of the powder and imparting instant moisturizing touch. In the second step, a cell-like membrane structure is directionally assembled to construct a biological affinity interface layer to simulate the cell membrane structure and achieve long-term skin adhesion without powder floating. Thus, the powder realizes a fundamental change from a "visually modified foreign object" to a "skin-friendly functional platform". Relying on its microstructure biomimetic characteristics, the double-layer biomimetic powder can form a fine powder film compatible with the skin texture after makeup, achieving seamless integration with the skin and achieving a second skin-like biomimetic effect.

[0070] A method for multi-level biomimetic modification of powder (such as titanium dioxide, iron oxide, zinc oxide, mica, talc, boron nitride, etc.) by simulating the components of human skin and the cell nucleus-cytoplasm-cell membrane microstructure, and a high-skin-friendly and high-stable powder prepared thereby and its application in skin covering agents.

[0071] Example 1:

[0072] 1. Disperse 120 g of titanium dioxide particles (100-200 nm) into 360 g of water, add 300 g of zirconium beads (0.3-0.4 mm), and adjust the speed of the sand mill to 2500 rpm. Sand mill for 30 min, filter, and take 400 g of the filtrate and heat to 60℃ while stirring.

[0073] 2. Add 1 g of sodium hyaluronate to 10 g of deionized water, and dissolve at room temperature or 60℃ until clear.

[0074] 3. Add the sodium hyaluronate solution of step 2 dropwise to the titanium dioxide suspension of step 1, and stir for 1 h at a speed of 500 rpm.

[0075] 4. Add 5 g of hydrogenated lecithin to 20 g of deionized water, and dissolve at 60℃ until clear.

[0076] 5. Slowly add the hydrogenated lecithin solution to step 3, adjust the speed to 250-300 rpm, and react for 1 h.

[0077] 6. After the reaction is completed, filter, wash with water, and dry at 80℃. The transmission electron microscope image of the sample is as follows: Figure 1 .

[0078] Example 2:

[0079] 1. Disperse 120 g of red iron oxide particles (1-3 μm) into 360 g of water, add 300 g of zirconium beads (0.3-0.4 mm), adjust the rotation speed of the sand mill to 2500 rpm, sand mill for 30 min, filter, and take 400 g of the filtrate and heat to 60 °C while stirring.

[0080] 2. Dissolve 5 g of sodium hyaluronate in 10 g of deionized water at room temperature or 60 °C until clear.

[0081] 3. Add the sodium hyaluronate solution of step 2 dropwise to the red iron oxide suspension of step 1, stir for 1 h at a rotation speed of 500 rpm.

[0082] 4. Dissolve 10 g of hydrogenated lecithin in 20 g of deionized water at 60 °C until clear.

[0083] 5. Slowly add the hydrogenated lecithin solution to step 3, adjust the rotation speed to 250-300 rpm, and react for 1 h.

[0084] 6. After the reaction is complete, filter, wash with water, and dry at 80 °C. The scanning electron microscope image of the sample is shown in Figure 2 and the elemental analysis chart is shown in Figure 3 .

[0085] Example 3

[0086] The difference from Example 1 is only that the base powder of Example 3 is titanium dioxide particles (200-300 nm).

[0087] Example 4

[0088] The difference from Example 1 is only that the base powder of Example 4 is yellow iron oxide (acicular long axis about 424 nm, short axis about 73 nm).

[0089] Example 5

[0090] The difference from Example 1 is only that the base powder of Example 5 is red iron oxide (acicular long axis about 598 nm, short axis about 86 nm).

[0091] Example 6

[0092] The difference from Example 1 is only that the base powder of Example 6 is black iron oxide (spherical, about 246 nm).

[0093] Comparative Example 1

[0094] 1. Disperse 100 g of titanium dioxide particles (100-200 nm) into 300 g of water and heat to 60 °C while stirring.

[0095] 2. Dissolve 1 g of sodium hyaluronate in 10 g of deionized water at room temperature or 60°C until clear.

[0096] 3. Add the sodium hyaluronate solution of step 2 dropwise to the titanium dioxide suspension of step 1 and stir for 1 h at 500 rpm.

[0097] 4. Dissolve 5 g of hydrogenated lecithin in 20 g of deionized water at 60°C until clear.

[0098] 5. Slowly add the hydrogenated lecithin solution to step 3 and adjust the stirring speed to 250-300 rpm and react for 1 h.

[0099] 6. After the reaction is complete, filter, wash with water, and dry at 80°C.

[0100] Comparative Example 2

[0101] 1. Disperse 120 g of titanium dioxide particles (100-200 nm) in 360 g of water and add 300 g of zirconium beads (0.3-0.4 mm). Adjust the speed of the sand mill to 2500 rpm and sand mill for 30 min. Filter and take 400 g of the filtrate and heat to 60°C while stirring.

[0102] 2. Dissolve 1 g of sodium hyaluronate in 10 g of deionized water at room temperature or 60°C until clear.

[0103] 3. Add the sodium hyaluronate solution of step 2 dropwise to the titanium dioxide suspension of step 1 and stir for 1 h at 500 rpm.

[0104] 4. After the reaction is complete, filter, wash with water, and dry at 80°C.

[0105] Comparative Example 3:

[0106] 1. Disperse 120 g of titanium dioxide particles (100-200 nm) in 360 g of water and add 300 g of zirconium beads (0.3-0.4 mm). Adjust the speed of the sand mill to 2500 rpm and sand mill for 30 min. Filter and take 400 g of the filtrate and heat to 60°C while stirring.

[0107] 2. Dissolve 5 g of hydrogenated lecithin in 20 g of deionized water at 60°C until clear.

[0108] 3. Slowly add the hydrogenated lecithin solution to step 3 and adjust the stirring speed to 250-300 rpm and react for 1 h.

[0109] 4. After the reaction is complete, filter, wash with water, and dry at 80°C.

[0110] Test Example 1

[0111] The modified powder obtained from Example 1, Example 4, Example 5 and Example 6 of the present application was used for the foundation liquid quantitative coating on the skin surface for skin feel test, and the results are shown in Table 1.

[0112] Table 1

[0113]

[0114] Figure 1 (a) Transmission electron micrograph of Example 1, (b) High resolution transmission electron micrograph of Example 1.

[0115] From Figure 1 (a) and 1(b), it can be seen that the powder after biomimetic treatment has a double-layer biomimetic structure Figure 1 (b) has a layer of light-colored amorphous structure, i.e. a double-layer biomimetic structure, indicating that the double-layer biomimetic treatment forms a core-shell structure.

[0116] Figure 2 (a) Scanning electron micrograph of iron oxide before biomimetic coating of Example 2, (b) Scanning electron micrograph of iron oxide after biomimetic coating of Example 2, (c) Scanning electron micrograph of iron oxide after biomimetic coating of Example 2, (d) Scanning electron micrograph of iron oxide after 2 hours of hydrochloric acid etching of Example 2.

[0117] From Figure 2 (a), it can be seen that the iron oxide is a rough ellipsoidal particle, and after double-layer biomimetic coating Figure 2 (b), 2(c), a uniform film structure is formed on the surface. In order to further confirm the existence of the biomimetic film, the product of Example 2 was etched with 10% HCl for 2 hours to obtain Figure 2 (d), the surface of the iron oxide is more rough, and a layer of film has fallen off the surface, again verifying the existence of the core-shell structure and the biomimetic film after coating.

[0118] Figure 3 Elemental analysis spectrum of the iron oxide after biomimetic coating of Example 2.

[0119] Figure 4 EDX energy spectrum analysis diagram corresponding to the elements.

[0120] Figure 4 From top to bottom, from left to right are the overall scanning electron micrograph, C element, O element, P element, and Fe element spectrum.

[0121] From Figure 3 and Figure 4 It can be seen that the particles of Example 2 after hydrochloric acid etching are mainly composed of Fe, O, C, P and N elements, and the parts of the biomimetic film structure are mainly composed of C and P elements, C and P are components of sodium hyaluronate and hydrogenated lecithin, indicating that the biomimetic film is composed of sodium hyaluronate and hydrogenated lecithin.

[0122] Figure 5 Comparison of blue light protection effects between (a) 0.01wt% commercially available nano titanium dioxide and (b) the solution from Example 1.

[0123] Depend on Figure 5 It is known that blue light can pass through commercially available nano titanium dioxide solution but cannot pass through the solution of Example 1, indicating that Example 1 has blue light protection properties.

[0124] Figure 6 (a) Blank emulsion, (b) Example 1 and (c) Red light transmission effect of commercially available Ti-18 AS.

[0125] Depend on Figure 6 It is known that when a beam of white light shines on the surface of Example 1, red light passes through, indicating that Example 1 has a skin-like red light transmission effect. Red light can reach deep into the skin but is not absorbed. Therefore, red light can bring a rosy complexion and make wrinkles, pores, uneven skin tone, and other problems less noticeable, resulting in a smooth facial makeup effect.

[0126] Figure 7 Formula test: Triethoxyoctylsilane formula of control group (a) and (a') and fineness test diagram of biomimetic powder formula of experimental group (b) and (b').

[0127] Depend on Figure 7 It is known that, using the same basic formula and biomimetic powder, the resulting foundation is fine and free of particles, with a higher degree of fineness.

[0128] Figure 8 Microscopic images of the control group (triethoxyoctylsilane formula) before and after oil production; microscopic images of the experimental group (biomimetic powder formula) before and after oil production.

[0129] The comparison photos before and after oil production show that the biomimetic powder applies more evenly and does not cake in textured areas. After oil production, the control group showed obvious foundation peeling and patchiness, while the experimental group's biomimetic powder was moistened but did not migrate, and the makeup did not show patchiness. This indicates that the biomimetic powder has a certain anti-sebum effect in the formula.

[0130] Figure 9 Photos of the control group (triethoxyoctylsilane formula) before and after air-drying the black and white card; photos of the experimental group (bionic powder formula) before and after air-drying the black and white card.

[0131] Figure 9 In the scratch test, the control group formulation showed obvious scratches, while the formulation treated with the double-layer biomimetic film of this invention had an intact surface without obvious scratches. This indicates that the biomimetic powder in the formulation has an anti-scratch effect.

[0132] Figure 10 The moisture and oil content of the control group (triethoxyoctylsilane formula) before and after makeup application was measured in the formula test. The moisture and oil content of the experimental group (biomimetic powder formula) before and after makeup application was measured in the formula test.

[0133] In the control group, facial moisture increased by 18% and oil decreased slightly by 2% after makeup application. However, in the double-layer biomimetic film group, moisture increased by 31% and oil decreased by 26% after makeup application, indicating that the double-layer biomimetic powder has a moisturizing and oil-controlling effect.

[0134] Figure 11 Color difference (DEcmc) trend over time for the control group triethoxyoctylsilane formulation and the experimental group biomimetic powder formulation.

[0135] Figure 11 The color difference of the experimental group's formula over time was smaller than that of the control group, indicating that the double-layer biomimetic powder has an anti-dulling effect.

[0136] Application Experiment 1

[0137] The modified powders obtained in Examples 1, 4 (iron oxide yellow), 5 (iron oxide red), and 6 (iron oxide black) of this invention were used in liquid foundation. The formulations of the liquid foundation are shown in Table 2.

[0138] Table 2

[0139]

[0140] Laboratory preparation process:

[0141] 1. Homogenize phase B at high speed for 3 minutes, then add phases A and C sequentially, heat to 80°C, and homogenize at high speed for 5 minutes until no color spots remain. Set aside for later use.

[0142] 2. Heat and stir phase D to 80°C, then keep warm until ready for use.

[0143] 3. Slowly add phase D to phase (A+B+C), homogenize at high speed for 5 minutes, cool down, defoam, and discharge.

[0144] Thirty volunteers, aged 25-55, were selected as research subjects. After applying the aforementioned foundation, their feedback was collected and recorded based on five aspects: moisturizing effect, skin adherence, makeup lasting power, smoothness, and coverage (out of 5). The statistical results are as follows: Figure 12 As shown:

[0145] From such Figure 12 The results of the makeup experience recorded from 30 volunteers showed that the foundation in Experiment 1 had sufficient moisturizing properties, was smooth and adhered well to the skin, had a light powdery feel, and had good makeup longevity.

[0146] The foregoing shows and describes the basic principles and main features of the application and the advantages of the application.

[0147] Those skilled in the art should understand that the application is not limited to the above-mentioned embodiments, and the above-mentioned embodiments and descriptions in the specification are only to illustrate the principles of the application. Without departing from the spirit and scope of the application, various changes and improvements can be made to the application, and these changes and improvements all fall within the scope of the claimed application. The scope of the application is defined by the appended claims and their equivalents.

Claims

1. A skin mimicking powder, characterized by, Comprising: Inorganic powder in the middle; The first wrapping structure layer is wrapped outside the inorganic powder; The second wrapping structure layer is wrapped outside the first wrapping structure layer; The inorganic powder is titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, mica, talc, silica, boron nitride, ultramarine, chromium green, or any one or more of the mixed inorganic powder obtained; The first wrapping structure layer is a humectant, The humectant is any one or more of the mixed high molecular polysaccharide humectant, small molecular polyol humectant, large molecular polyol humectant, high molecular polypeptide humectant, amide compound humectant; The second wrapping structure layer is any one or more of phospholipid or phospholipid derivative.

2. The skin biomimetic powder according to claim 1, wherein The high molecular polysaccharide humectant is sodium hyaluronate; The small molecular polyol humectant is glycerol; The large molecular polyol humectant is polyglycerol; The high molecular polypeptide humectant is polyglutamic acid; The amide compound humectant is ceramide.

3. The skin biomimetic powder according to claim 1, wherein The phospholipid or phospholipid derivative is any one or more of lecithin, hydrogenated lecithin, phosphatidylserine.

4. A method of preparing a skin biomimetic powder according to any one of claims 1 to 3, wherein Comprising the following steps: Dissolve the humectant in deionized water or ethanol until clear, and then add the obtained solution B dropwise to the suspension A formed by dispersing the inorganic powder in water, Then add the solution C obtained by dissolving the phospholipid or phospholipid derivative in deionized water until clear dropwise to the aforementioned product, Then slowly stir to form a stable double-layer structure, control the pH to be 5-7, and the reaction time to be 1-2h, then filter, wash with water, and dry to obtain the skin biomimetic powder structure; The mass ratio of inorganic powder, humectant, and phospholipid or phospholipid derivative in the skin biomimetic powder structure is 85-99.9:0.1-5:1-10.

5. The method for preparing a skin-inspired biomimetic powder as described in claim 4, characterized in that, Specifically comprising the following steps: First, disperse the inorganic powder into water, sand mill dispersion, filtration, and filtration to form a suspension A, and heat to 50-60℃ while stirring; Second, dissolve the humectant in deionized water or ethanol until clear to obtain solution B; Third, add the solution B dropwise to the suspension A, control the pH to be 5-7, and the temperature to be 50-60℃, and react for 1-3h; Fourth, dissolve the phospholipid or phospholipid derivative in deionized water until clear to obtain solution C; Fifth, add the solution C dropwise to the product of the third step, and slowly stir to form a stable double-layer structure, control the pH to be 5-7, and the reaction time to be 1-2h, then filter, wash with water, and dry to obtain the skin biomimetic powder structure; The mass ratio of inorganic powder, humectant, and phospholipid or phospholipid derivative in the skin biomimetic powder structure is 85-99.9:0.1-5:1-10.

6. The preparation method of the skin biomimetic powder according to claim 5, wherein The sand mill dispersion of the first step is carried out at a rotation speed of 2000-3000rpm for 10-40min using zirconium beads.

7. The method for preparing a skin-inspired biomimetic powder as described in claim 6, characterized in that, The zirconium beads are 0.3-0.4mm in size.

8. The method of claim 5, wherein the inorganic powder is any one or more of titanium dioxide particles of 100-200 nm, red iron oxide particles of 1-3 μm, titanium dioxide particles of 200-300 nm, yellow iron oxide, red iron oxide, black iron oxide, mica, synthetic fluorphlogopite, boron nitride, ultramarine, chromium green; the temperature of the second step is room temperature or 50-60 °C; the temperature of the fourth step is 50-60 °C; the slow stirring of the fifth step is at a rate of no more than 300 rpm. the application is for use in manufacturing a covering or a mask for a skin surface.

9. Use of a skin-bionimic powder according to any one of claims 1-3, characterized in that, ​

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