Intelligence-promoting and mind-tranquilizing liquid and preparation method thereof

By scientifically combining herbs such as Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora, Yizhi Ningshen Liquid was prepared, which solved the problems of unstable efficacy and side effects of existing Yizhi Ningshen drugs, and achieved the synergistic effect of multiple pharmacodynamics and enhanced safety.

CN121622800APending Publication Date: 2026-03-10GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-04
Publication Date
2026-03-10

AI Technical Summary

Technical Problem

Existing drugs for treating mental disorders and relieving anxiety have problems such as unstable efficacy, complex ingredients, complicated preparation process, and possible side effects, which make them inconvenient for patients to use.

Method used

The formula uses a scientific combination of medicinal materials such as Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora. The formula is prepared by decoction or extraction and concentration. Combined with ethanol and preservatives, it forms a stable medicinal effect.

Benefits of technology

It achieves synergistic effects of multiple pharmacodynamics, improves treatment efficacy, enhances drug safety, improves patients' quality of life, has a wide range of applications, and provides long-lasting and stable efficacy.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention discloses an intelligence-promoting and mind-calming liquid and a preparation method thereof, and relates to the technical field of medicine preparation, the intelligence-promoting and mind-calming liquid is mainly composed of the following components, and the content of each component should be adjusted according to actual needs and treatment effects. The reference content ranges are as follows: 10-30 parts of radix astragali, 5-15 parts of dragon bone, 5-15 parts of rhizoma acori graminei, 10-30 parts of radix rehmanniae preparata, 5-15 parts of polygala tenuifolia, 5-15 parts of rhizoma atractylodis macrocephalae and 5-15 parts of radix paeoniae alba. The invention also provides a preparation method and a process production flow of the intelligence-promoting and mind-calming liquid. On the basis of the prior art, through scientific compatibility, the characteristics of all the medicinal materials are fully played, multiple effects of tonifying spleen and nourishing kidney, calming liver and suppressing yang, tranquilizing mind and promoting intelligence, and reducing phlegm and inducing resuscitation are achieved, and the traditional Chinese medicine has remarkable beneficial effects. Meanwhile, the industrial production process can solve the problems that in the prior art, medicine is prepared through a traditional method, and consequently the medicine is unstable in curative effect and complex in component.
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Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation technology, and more specifically, to an invigorating and calming liquid and its preparation method. Background Technology

[0002] In the field of traditional Chinese medicine, herbal decoctions or prepared medicines are often used to regulate the body and achieve the effects of improving intelligence and calming the mind in order to treat mental and nervous disorders such as insomnia and anxiety. These medicines can harmonize the heart and spleen, improve intelligence and open the orifices, nourish yin and clear heat, strengthen the spleen and stomach, consolidate kidney qi, calm the mind and soothe the nerves, and enhance memory. They can also help alleviate symptoms of ADHD.

[0003] However, these nootropic and calming drugs prepared using traditional methods often have problems such as unstable efficacy, complex ingredients, and cumbersome preparation processes, which make them inconvenient for patients to use, and some products may have certain side effects. Summary of the Invention

[0004] The purpose of this invention is to provide a brain-boosting and calming liquid and its preparation method to overcome the deficiencies in the prior art.

[0005] The above-mentioned technical objective of the present invention is achieved through the following technical solution: a brain-boosting and mind-calming liquid, wherein the weight parts of each raw material in the brain-boosting and mind-calming liquid are as follows: 10-30 parts of Astragalus membranaceus, 5-15 parts of dragon bone, 5-15 parts of Acorus tatarinowii, 10-30 parts of Rehmannia glutinosa, 5-15 parts of Polygala tenuifolia, 5-15 parts of Atractylodes macrocephala, and 5-15 parts of Paeonia lactiflora.

[0006] The present invention is further configured such that the preferred weight proportions of each ingredient in the Yizhi Ningshen Liquid are: Astragalus membranaceus 20 parts, Dragon bone 10 parts, Acorus tatarinowii 10 parts, Rehmannia glutinosa 20 parts, Polygala tenuifolia 10 parts, Atractylodes macrocephala 10 parts, and Paeonia lactiflora 10 parts.

[0007] Astragalus: A qi-tonifying herb that invigorates yang, strengthens the defensive qi, promotes diuresis and reduces swelling, and generates fluids and nourishes blood.

[0008] Dragon bones: Dragon bones are fossilized bones of ancient mammals such as elephants, rhinoceroses, three-toed horses, cattle, and deer. They are used to calm the mind, soothe the liver, suppress yang, and astringe and stop seminal emission.

[0009] Acorus tatarinowii: A medicine for opening the mind. Acorus tatarinowii has a variety of pharmacological effects, including sedation, anticonvulsant, antidepressant, improving learning and memory, protecting against ischemic damage to the heart and brain, regulating gastrointestinal motility, relieving asthma, expectorant, and antitussive effects.

[0010] Rehmannia glutinosa (processed): A tonic herb with various pharmacological effects, including promoting hematopoiesis, enhancing memory, boosting immunity, and lowering blood sugar.

[0011] Polygala tenuifolia: a sedative drug with various pharmacological effects such as sedation, hypnosis, antidepressant, improving learning and memory, and antitussive and expectorant effects;

[0012] Atractylodes macrocephala: A tonic herb with various pharmacological effects such as anti-digestive ulcer, promoting gastrointestinal motility, liver protection, choleretic effect, enhancing the body's immune function, anti-oxidation, anti-tumor, hypoglycemia, anticoagulation, and antibacterial effects.

[0013] White peony root: A tonic herb with various pharmacological effects, including enhancing phagocytic function, cellular immunity, humoral immunity, dilating coronary blood vessels, enhancing hematopoietic function, sedation, analgesia, and liver protection.

[0014] This invention further provides a method for preparing a brain-boosting and calming liquid, comprising the following steps:

[0015] S1. Mix Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora in the specified proportions;

[0016] S2. Use the decoction method. Soak the mixed medicinal materials in water until soft, then decoct for 1-2 hours.

[0017] S3. After decoction is completed, filter the liquid, collect the filtrate, decoct the dregs again to obtain filtrate, and combine the two filtrates;

[0018] S4. Concentrate the filtrate from S3 to the desired concentration, add flavoring sugar, and cool;

[0019] S5. Bottle and seal, store in a cool, dry place.

[0020] This invention further provides a process for preparing a brain-boosting and calming liquid, comprising the following steps:

[0021] S1. Mix Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora in a certain proportion, add water and extract three times, one hour each time. Collect 200ml of distillate from the first extraction and store it in a separate container.

[0022] S2. After filtering the three extracts separately, combine the filtrates, concentrate them at 80℃ to a relative density of 1.08-1.18, cool, add ethanol to make the alcohol content reach 65%, and let stand for 24 hours.

[0023] S3. Filtration, recovery of ethanol from the filtrate and concentration to a relative density of not less than 1.15;

[0024] S4. Add 100g of sucrose and 2.5g of sodium benzoate, heat to dissolve, and let stand for 48 hours;

[0025] S5. Add the distillate collected during the first extraction. Add 0.5 ml of polysorbate 80 to the distillate beforehand, mix well, add water to 1000 ml, dispense, sterilize, and you will get the Yizhi Ningshen liquid.

[0026] The Invigorating and Calming Liquid provided by this invention is composed of seven medicinal herbs: Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Atractylodes macrocephala, Polygala tenuifolia, and Paeonia lactiflora. Based on existing technologies, this invention, through scientific formulation, fully utilizes the characteristics of each herb to achieve multiple effects, including strengthening the spleen and kidneys, calming the liver and suppressing yang, calming the mind and improving intelligence, and resolving phlegm and opening the orifices, thus exhibiting significant beneficial effects.

[0027] First, the Astragalus membranaceus and Dragon Bone used in this invention are the principal herbs, which have the effects of strengthening the spleen and replenishing qi, calming the liver and suppressing yang. They can effectively eliminate symptoms such as spleen qi deficiency and liver yang hyperactivity, thereby improving bodily functions and enhancing the quality of life of patients.

[0028] Secondly, Acorus tatarinowii and Rehmannia glutinosa, as assistant herbs, have the effects of calming the mind, clearing the orifices, and tonifying the liver and kidneys. Based on the original technology, this invention further enhances the effects of calming the mind, improving intelligence, and tonifying the liver and kidneys, which helps to improve the patient's nervous system function, enhance memory, and improve work efficiency.

[0029] Furthermore, Atractylodes macrocephala, Polygala tenuifolia, and Paeonia lactiflora are used as adjuvant herbs to work together to invigorate qi and strengthen the spleen, resolve phlegm and open the orifices, nourish the liver and kidneys, and calm the mind and subdue yang. Compared with existing technologies, this invention has a synergistic effect in terms of efficacy, which can better alleviate the condition and improve the treatment effect.

[0030] In summary, the present invention has the following beneficial effects:

[0031] 1. Improved treatment efficacy: The traditional Chinese medicine prescription used in this invention can comprehensively regulate the body according to the cause of the disease, exert multiple medicinal effects, improve the success rate of treatment, and reduce the recurrence rate.

[0032] 2. Improve patients' quality of life: This invention can effectively alleviate symptoms, reduce patient suffering, and improve quality of life.

[0033] 3. Enhanced drug safety: The medicinal materials used in this invention are all natural plants with fewer toxic side effects and higher safety.

[0034] 4. Long-lasting and stable efficacy: The traditional Chinese medicine prescription of this invention, through scientific formulation, has a long-lasting and stable efficacy, which is beneficial for long-term use.

[0035] 5. Wide range of applications: This invention is applicable to the treatment of various diseases caused by spleen deficiency, liver yang hyperactivity, and nervous system dysfunction, and has broad clinical application value.

[0036] In summary, this invention overcomes the shortcomings of existing technologies and provides a traditional Chinese medicine prescription with significant beneficial effects, offering new ideas and methods for clinical treatment, and has high practical value and promotional significance. Attached Figure Description

[0037] Figure 1This is the process flow for preparing the Yizhi Ningshen Liquid in this invention. Detailed Implementation

[0038] The following is in conjunction with the appendix Figure 1 The present invention will be described in further detail below.

[0039] Example 1: The composition of the Yizhi Ningshen Liquid in this example is as follows:

[0040] Chief herbs: 10 grams of high-quality Astragalus membranaceus and 10 grams of dragon bone. Astragalus membranaceus has the effects of tonifying qi and consolidating the exterior, promoting diuresis and reducing swelling, while dragon bone has the effects of calming the mind and relieving anxiety, and astringing and consolidating.

[0041] The accompanying ingredients are: 10 grams of Acorus tatarinowii and 20 grams of Rehmannia glutinosa. Acorus tatarinowii can open the orifices and refresh the mind, improve intelligence and calm the nerves, while Rehmannia glutinosa has the effects of nourishing yin and blood, replenishing essence and marrow.

[0042] The adjuvant herbs are: 10 grams each of Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora. Polygala tenuifolia can calm the mind and soothe the nerves, improve intelligence and strengthen will. Atractylodes macrocephala can invigorate qi and strengthen the spleen, harmonize the stomach and stop diarrhea. Paeonia lactiflora can nourish blood, regulate menstruation, and relieve muscle pain.

[0043] The specific preparation method in this embodiment is as follows:

[0044] Weigh the astragalus, dragon bone, acorus, rehmannia, polygala, atractylodes, and white peony according to the above proportions, and mix them evenly.

[0045] Place the mixed herbs into a decoction container, add an appropriate amount of purified water, and decoct using the water decoction method, controlling the decoction time to 1.5 hours;

[0046] The herbs need to be stirred frequently during the decoction process to ensure they are fully cooked.

[0047] After decoction, the liquid is filtered through a filtration device and the filtrate is collected.

[0048] The filtrate is transferred to a concentration device and concentrated to the desired concentration.

[0049] After the concentrated medicine solution is cooled to room temperature, an appropriate amount of sodium benzoate is added as a preservative.

[0050] Dispense the liquid medicine into clean bottles, seal them, and store them in a cool, dry place to ensure a shelf life of up to 6 months.

[0051] Example 2: The composition of the Yizhi Ningshen Liquid in this example is as follows:

[0052] The principal herbs are Astragalus membranaceus 30g and Dragon Bone 15g, which enhance the effects of the herbs in tonifying Qi, strengthening the exterior, calming the mind, and soothing the nerves.

[0053] Assistant herbs: 15 grams of Acorus tatarinowii and 30 grams of Rehmannia glutinosa, to enhance the effects of improving intelligence, calming the mind, nourishing yin and blood;

[0054] The adjuvant herbs are: 15g each of Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora, which enhance the effects of calming the mind, invigorating qi and spleen, nourishing blood and regulating menstruation.

[0055] The preparation method of this embodiment is described in detail below:

[0056] Weigh the medicinal materials according to the above proportions and mix them evenly;

[0057] Place the mixed herbs into a decoction container, add enough purified water, and decoct using the water decoction method, extending the decoction time to 2 hours.

[0058] Stir frequently during the decoction process to ensure the herbs are fully cooked.

[0059] After decocting, filter the liquid and collect the filtrate.

[0060] Concentrate the filtrate to the required concentration, cool it, and then add an appropriate amount of potassium sorbate as a preservative.

[0061] The concentrated medicine is dispensed into bottles, sealed, and stored in a cool, dry place. The shelf life is up to 12 months.

[0062] Example 3: The composition of the Yizhi Ningshen Liquid in this example is as follows:

[0063] The principal ingredients are: 20 grams of Astragalus membranaceus and 10 grams of dragon bone, which maintain the effects of tonifying qi, strengthening the exterior, calming the mind, and soothing the nerves.

[0064] Assistant herbs: 10 grams of Acorus tatarinowii and 25 grams of Rehmannia glutinosa, to enhance the effects of improving intelligence, calming the mind, nourishing yin and blood;

[0065] The adjuvant herbs are: 10 grams each of Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora, which maintain the effects of calming the mind and soothing the nerves, invigorating qi and strengthening the spleen, nourishing blood and regulating menstruation.

[0066] The specific preparation method in this embodiment is as follows:

[0067] Weigh the medicinal materials according to the above proportions and mix them evenly;

[0068] Place the mixed herbs into a decoction container, add an appropriate amount of purified water, and decoct using the water decoction method for 1.75 hours.

[0069] The herbs must be stirred constantly during the decoction process to ensure they are fully cooked.

[0070] After decoction, the liquid is filtered through a filtration device and the filtrate is collected.

[0071] Concentrate the filtrate to the desired concentration, cool it, and then add an appropriate amount of vitamin E as a natural preservative.

[0072] Dispense the liquid medicine into clean bottles, seal them, and store them in a cool, dry place. The shelf life can reach 9 months.

[0073] Example 4: The composition of the Yizhi Ningshen Liquid in this example is as follows:

[0074] The principal ingredients are: 20 grams of Astragalus membranaceus and 10 grams of dragon bone, which maintain the effects of tonifying qi, strengthening the exterior, calming the mind, and soothing the nerves.

[0075] Assistant herbs: 10 grams of Acorus tatarinowii and 25 grams of Rehmannia glutinosa, to enhance the effects of improving intelligence, calming the mind, nourishing yin and blood;

[0076] The adjuvant herbs are: 10 grams each of Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora, which maintain the effects of calming the mind and soothing the nerves, invigorating qi and strengthening the spleen, nourishing blood and regulating menstruation.

[0077] The specific preparation method in this embodiment is as follows:

[0078] Mix Astragalus membranaceus, dragon bone, Acorus tatarinowii, Rehmannia glutinosa, Polygala tenuifolia, Atractylodes macrocephala, and Paeonia lactiflora in a certain proportion, add water and extract three times, one hour each time. Collect 200ml of distillate from the first extraction and store it in a separate container.

[0079] After filtering the three extracts separately, the filtrates were combined and concentrated at 80°C to a relative density of 1.08–1.18. The mixture was cooled, and ethanol was added to make the alcohol content reach 65%. The mixture was then allowed to stand for 24 hours.

[0080] Filtration, recovery of ethanol from the filtrate and concentration to a relative density of not less than 1.15;

[0081] Add 100g of sucrose and 2.5g of sodium benzoate, heat to dissolve, and let stand for 48 hours;

[0082] Add the distillate collected during the first extraction, pre-add 0.5 ml of polysorbate 80 to the distillate, mix well, add water to 1000 ml, dispense, sterilize, and you will get the Yizhi Ningshen Liquid.

[0083] The industrial production of this invigorating and calming liquid can be achieved by adding the medicine and other ingredients in appropriate proportions according to production needs. The main equipment used in the production process is as follows:

[0084]

[0085] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A liquid for nourishing the brain and tranquilizing the mind, characterized in that: The weight parts of each raw material of the Yizhi Ning Shen liquid are as follows: 10-30 parts of Huangqi, 5-15 parts of Longgu, 5-15 parts of Shichangpu, 10-30 parts of Shudi, 5-15 parts of Yuanzhi, 5-15 parts of Baishu, and 5-15 parts of Baishao. ​ 2. The Yizhining Shen liquid according to claim 1, characterized in that: The weight parts of each raw material of the Yizhi Ning Shen liquid are preferably as follows: 20 parts of Huangqi, 10 parts of Longgu, 10 parts of Shichangpu, 20 parts of Shudi, 10 parts of Yuanzhi, 10 parts of Baishu, and 10 parts of Baishao.

3. The preparation method of the Yizhining Shen liquid according to claim 1, characterized in that: The method comprises the following steps: S1. Huangqi, Longgu, Shichangpu, Shudi, Yuanzhi, Baishu, and Baishao are mixed according to the proportions; S2. The mixed medicinal materials are soaked in water and then decocted by using the water decoction method, and the decoction time is 1-2 hours; S3. After the decoction is completed, the medicinal liquid is filtered, the filtrate is collected, the residue is decocted again, the filtrate is obtained, and the two filtrates are combined; S4. The filtrate of S3 is concentrated to the required concentration, sugar is added for seasoning, and the mixture is cooled; S5. The mixture is bottled, sealed, and stored in a cool and dry place.

4. The process for preparing the Yizhining Shen liquid according to claim 1, characterized in that: The method comprises the following steps: S1. Huangqi, Longgu, Shichangpu, Shudi, Yuanzhi, Baishu, and Baishao are mixed according to the proportions, and water is added for extraction three times, 1 hour each time, and the distillate of 200 ml is collected in another container during the first extraction; S2. The three extraction liquids are filtered respectively, the filtrates are combined, concentrated to a relative density of 1.08-1.18 at 80°C, cooled, and then ethanol is added to make the alcohol content reach 65%, and the mixture is left to stand for 24 hours; S3. The mixture is filtered, the filtrate is recovered for ethanol and concentrated to a relative density of not less than 1.15; S4. 100 g of sucrose and 2.5 g of sodium benzoate are added, heated to dissolve, and left to stand for 48 hours; S5. The distillate collected during the first extraction is added, 0.5 ml of polysorbate 80 is added to the distillate in advance, mixed, water is added to 1000 ml, and the mixture is divided, sterilized, and then the Yizhi Ning Shen liquid is obtained.