Pure plant compound liquid for removing warts and repairing skin cuticle barrier and preparation method of pure plant compound liquid

Abstract

The invention relates to the technical field of skin care, and discloses pure plant compound liquid for removing warts and repairing a skin cuticle barrier and a preparation method of the pure plant compound liquid. The compound liquid is prepared by compounding a purslane extract, a brucea javanica extract, a honeysuckle extract, a licorice extract, an aloe extract, hyaluronic acid, glycerin, menthol and deionized water according to specific parts by weight. The preparation method comprises the steps of raw material pretreatment, basic liquid preparation, active ingredient addition, seasoning and homogenization, filtration and sterilization and the like. Whole plant extracts are adopted as core active ingredients, the synergistic effect of resisting viruses, removing warts, resisting inflammation and repairing skin barriers is achieved through scientific compounding, the activity of human papilloma viruses can be efficiently inhibited, wart shedding is promoted, damaged cuticles can be repaired, and skin resistance can be enhanced; the product is free of chemical preservatives and corrosive components, high in safety, small in irritation, suitable for various skin types, simple in preparation process and suitable for industrial large-scale production.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of skin care, in particular to a pure plant compound solution for repairing skin horny layer barrier based on wart removal and a preparation method thereof. BACKGROUND

[0002] Warts are benign skin neoplasms caused by human papillomavirus (HPV) infection of the skin mucosa, commonly found on the hands, feet, face and other parts, not only affecting the appearance of the skin, but also some warts may cause ulceration and infection due to friction and scratching, causing discomfort to the patient. At present, the methods for removing warts in clinical practice mainly include physical treatment and drug treatment. Physical treatment such as freezing, laser, and electric cauterization can quickly remove the wart body, but has problems such as large trauma, strong pain, easy scarring, and possible damage to the surrounding normal skin tissue. In addition, the skin horny layer barrier is easily damaged after the operation, resulting in symptoms such as dryness, redness, and sensitivity. Drug treatment often uses preparations containing corrosive ingredients such as salicylic acid and podophyllotoxin. Such drugs have a certain effect on wart removal, but at the same time, they can stimulate normal skin, damage the skin horny layer barrier, and cause the skin to lose resistance, and even may cause secondary infection. In addition, some patients have allergic reactions to chemical drugs, limiting their applicability.

[0003] With the pursuit of natural and gentle skin care concepts, pure plant-derived skin care and treatment products have received widespread attention. Active ingredients such as flavonoids, polyphenols, and terpenes contained in plants have various functions such as antiviral, antibacterial, anti-inflammatory, and skin barrier repair, and are safe and less irritating, making them suitable for long-term use. However, existing pure plant wart removal products have problems such as limited efficacy of single ingredients, long wart removal period, or focusing only on wart removal while ignoring skin barrier repair, making it difficult to achieve both efficient wart removal and gentle repair. Therefore, developing a pure plant compound solution with natural ingredients, significant wart removal effect, and simultaneous repair of the skin horny layer barrier has become a research hotspot in the field of skin care. SUMMARY

[0004] (I) Technical problems solved In view of the deficiencies of the prior art, the present application provides a pure plant compound solution for repairing skin horny layer barrier based on wart removal and a preparation method thereof. The compound solution is compounded with multiple pure plant extracts, which can not only inhibit the activity of human papillomavirus and promote the shedding of warts, but also repair the damaged skin horny layer barrier and enhance the skin resistance, and is safe and non-irritating.

[0005] (II) Technical solutions To achieve the above object, the present application provides the following technical scheme: A pure plant compound solution based on wart-removing skin stratum corneum barrier repair, which is composed of the following raw materials in parts by weight: 8-15 parts of spironolactone extract, 5-10 parts of calophyllum inophyllum extract, 6-12 parts of honeysuckle extract, 4-8 parts of licorice extract, 10-18 parts of aloe extract, 2-5 parts of hyaluronic acid, 3-6 parts of glycerol, 0.5-2 parts of menthol, and 50-80 parts of deionized water.

[0006] Further, it is composed of the following raw materials in parts by weight: 10-12 parts of spironolactone extract, 7-9 parts of calophyllum inophyllum extract, 8-10 parts of honeysuckle extract, 5-7 parts of licorice extract, 12-16 parts of aloe extract, 3-4 parts of hyaluronic acid, 4-5 parts of glycerol, 1-1.5 parts of menthol, and 60-70 parts of deionized water.

[0007] Further, it is composed of the following raw materials in parts by weight: 11 parts of spironolactone extract, 8 parts of calophyllum inophyllum extract, 9 parts of honeysuckle extract, 6 parts of licorice extract, 14 parts of aloe extract, 3.5 parts of hyaluronic acid, 4.5 parts of glycerol, 1.2 parts of menthol, and 65 parts of deionized water.

[0008] Further, the spironolactone extract is prepared by the following method: fresh spironolactone is washed, crushed, and then 5-8 times the weight of 70%-80% ethanol solution is added, and reflux extraction is carried out at 50-60°C for 2-3 hours, and the extraction is carried out twice, the extraction liquid is combined, and concentrated under reduced pressure to remove the alcohol taste, to obtain the spironolactone extract.

[0009] Further, the calophyllum inophyllum extract is prepared by the following method: the calophyllum inophyllum fruit is shelled and crushed, 6-10 times the weight of 60%-75% ethanol solution is added, and ultrasonic extraction is carried out for 30-60 minutes, the extraction temperature is 40-50°C, the extraction is carried out twice, the extraction liquid is combined, filtered, and concentrated under reduced pressure, to obtain the calophyllum inophyllum extract.

[0010] Further, the honeysuckle extract and the licorice extract are both prepared by water extraction and alcohol precipitation method, and the specific steps are as follows: the corresponding plant raw materials are washed, crushed, 8-12 times the weight of deionized water is added, and boiling extraction is carried out for 1-2 hours, the extraction is carried out twice, the extraction liquid is combined, and concentrated to a relative density of 1.10-1.20 of the extract, ethanol is added to a volume fraction of 60%-70%, and then placed for 12-24 hours, filtered, and the filtrate is concentrated under reduced pressure to remove the alcohol taste, to obtain the corresponding extract.

[0011] Further, the aloe extract is a concentrated solution obtained by centrifugation, filtration, and concentration of aloe fresh juice, and the solid content is 20%-30%.

[0012] Further, it includes the following steps: (1) Raw material pretreatment: Weigh out the following ingredients by weight: purslane extract, croton extract, honeysuckle extract, licorice extract, aloe extract, hyaluronic acid, glycerin, menthol, and deionized water, and set aside. (2) Preparation of base solution: Add deionized water to the reaction vessel, heat to 40-50℃, stir evenly, add hyaluronic acid and glycerin in sequence, and continue stirring for 15-25 minutes until the raw materials are completely dissolved to obtain the base solution; (3) Addition of active ingredients: Keep the temperature of the reactor at 35-45℃, and add purslane extract, croton extract, honeysuckle extract, licorice extract and aloe extract to the base solution in sequence. Stir while adding, and the stirring speed is 150-200r / min. Stir for 30-40 minutes to make the active ingredients fully mixed. (4) Flavoring and homogenization: Add menthol to the above mixture and continue stirring for 10-15 minutes. Then use a high-pressure homogenizer to homogenize 2-3 times at a pressure of 20-30 MPa for 5-8 minutes each time to obtain a homogenized liquid. (5) Filtration and sterilization: Cool the homogenized liquid to room temperature, filter it through a 0.45μm filter membrane to remove impurities, and then sterilize it with ultraviolet sterilization for 15-20 minutes to obtain pure plant compound liquid.

[0013] The compound solution of this invention exhibits synergistic effects and complementary efficacy among its various raw materials. Purslane extract, containing purslane polysaccharides, flavonoids, and other active ingredients, possesses significant antiviral and anti-inflammatory effects, inhibiting human papillomavirus replication and reducing skin inflammation. Brucea javanica extract contains crotonin, which has strong antifungal and antiviral activity, destroying wart tissue and promoting wart shedding, with minimal irritation to normal skin. Honeysuckle extract contains chlorogenic acid and flavonoids, which have antibacterial, antiviral, and anti-inflammatory effects, enhancing the antiviral capacity of the compound solution and preventing skin infections. Licorice... The dipotassium glycyrrhizate in the extract has anti-inflammatory, soothing, and skin barrier repairing effects, which can relieve skin irritation caused during wart removal and repair damaged stratum corneum cells; the aloe vera extract contains aloe polysaccharides, vitamins, and other ingredients, which have moisturizing, nourishing, and skin-repairing effects, can replenish skin moisture and nutrients, enhance the skin's water-locking ability, and improve dry and rough skin; hyaluronic acid and glycerin, as moisturizers, can further enhance the moisturizing effect of the compound solution and maintain the skin's hydrated state; menthol has a cooling and antipruritic effect, which can relieve skin itching and discomfort.

[0014] (iii) Beneficial technical effects This invention's pure plant-based compound solution uses whole plant extracts as its core active ingredients, combined with natural moisturizers. It contains no chemical preservatives or corrosive ingredients, ensuring high safety and low irritation, making it suitable for all skin types, especially sensitive skin. It achieves a synergistic effect of antiviral, wart removal, anti-inflammatory, and skin barrier repair, effectively removing warts while simultaneously repairing the damaged stratum corneum barrier. This solves the problem of existing wart removal products easily damaging the skin barrier, reducing the risk of post-operative skin sensitivity and infection. The preparation method of this invention is simple, convenient, and has low production costs, making it suitable for large-scale industrial production. Detailed Implementation

[0015] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are described clearly and completely. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0016] Example 1 A pure plant compound liquid based on wart removal and repair of the skin's stratum corneum barrier is composed of the following raw materials in parts by weight: 8 parts purslane extract, 5 parts Brucea javanica extract, 6 parts honeysuckle extract, 4 parts licorice extract, 10 parts aloe vera extract, 2 parts hyaluronic acid, 3 parts glycerin, 0.5 parts menthol, and 50 parts deionized water.

[0017] Its preparation method includes the following steps: (1) Raw material pretreatment: Weigh each raw material according to the above weight parts. The preparation method of purslane extract is as follows: Take fresh purslane, wash and crush it, add 5 times the weight of 70% ethanol solution, reflux extract at 50℃ for 2 hours, extract twice, combine the extracts, and concentrate under reduced pressure until there is no alcohol taste. The preparation method of croton extract is as follows: Take croton fruit, remove the shell and crush it, add 6 times the weight of 60% ethanol solution, ultrasonically extract for 30 minutes at 40℃, extract twice, combine the extracts, filter and concentrate under reduced pressure. Honeysuckle extract and licorice extract are prepared by water extraction and alcohol precipitation: Take the corresponding plant raw materials, wash and crush them, add 8 times the weight of deionized water, boil and extract for 1 hour, extract twice, combine the extracts, concentrate to a relative density of 1.10 (60℃), add ethanol to 60% ethanol volume fraction, stand for 12 hours, filter, and concentrate the filtrate under reduced pressure until there is no alcohol taste. Aloe extract is an aloe concentrate with a solid content of 20%. (2) Preparation of base solution: Add deionized water to the reaction vessel, heat to 40°C, stir evenly, add hyaluronic acid and glycerin in sequence, and continue stirring for 15 minutes until the raw materials are completely dissolved to obtain the base solution; (3) Addition of active ingredients: Keep the temperature of the reactor at 35°C, and add purslane extract, croton extract, honeysuckle extract, licorice extract and aloe extract to the base solution in sequence while stirring at a speed of 150 r / min for 30 minutes. (4) Flavoring and homogenization: Add menthol to the above mixture and continue stirring for 10 minutes. Then, use a high-pressure homogenizer to homogenize twice at a pressure of 20 MPa for 5 minutes each time to obtain a homogenized liquid. (5) Filtration and sterilization: Cool the homogenized liquid to room temperature, filter it through a 0.45μm filter membrane, and then sterilize it with ultraviolet sterilization for 15 minutes to obtain pure plant compound liquid.

[0018] Example 2 A pure plant compound liquid based on wart removal and repair of the skin's stratum corneum barrier is composed of the following raw materials in parts by weight: 11 parts purslane extract, 8 parts Brucea javanica extract, 9 parts honeysuckle extract, 6 parts licorice extract, 14 parts aloe vera extract, 3.5 parts hyaluronic acid, 4.5 parts glycerin, 1.2 parts menthol, and 65 parts deionized water.

[0019] Its preparation method includes the following steps: (1) Raw material pretreatment: Weigh each raw material according to the above weight parts. The preparation method of purslane extract is as follows: Take fresh purslane, wash and crush it, add 6.5 times the weight of 75% ethanol solution, reflux extract at 55℃ for 2.5 hours, extract twice, combine the extracts, and concentrate under reduced pressure until there is no alcohol taste. The preparation method of Brucea javanica extract is as follows: Take Brucea javanica fruit, remove the shell and crush it, add 8 times the weight of 70% ethanol solution, ultrasonically extract for 45 minutes at 45℃, extract twice. The extracts were combined, filtered, and concentrated under reduced pressure. Honeysuckle extract and licorice extract were prepared by water extraction and alcohol precipitation: the corresponding plant raw materials were taken, washed, crushed, and 10 times their weight of deionized water were added. The mixture was boiled and extracted for 1.5 hours, and the extraction was repeated twice. The extracts were combined and concentrated to a paste with a relative density of 1.15 (60℃). Ethanol was added to a volume fraction of 65%, and the mixture was allowed to stand for 18 hours. The mixture was filtered, and the filtrate was concentrated under reduced pressure until there was no alcohol odor. Aloe extract was an aloe concentrate with a solid content of 25%. (2) Preparation of base solution: Add deionized water to the reaction vessel, heat to 45°C, stir evenly, add hyaluronic acid and glycerin in sequence, and continue stirring for 20 minutes until the raw materials are completely dissolved to obtain the base solution; (3) Addition of active ingredients: Keep the temperature of the reactor at 40°C, and add purslane extract, croton extract, honeysuckle extract, licorice extract and aloe extract to the base solution in sequence while stirring at a speed of 180 r / min for 35 minutes. (4) Flavoring and homogenization: Add menthol to the above mixture and continue stirring for 12 minutes. Then, use a high-pressure homogenizer to homogenize three times at a pressure of 25 MPa for 6 minutes each time to obtain a homogenized liquid. (5) Filtration and sterilization: Cool the homogenized liquid to room temperature, filter it through a 0.45μm filter membrane, and then sterilize it with ultraviolet sterilization for 18 minutes to obtain pure plant compound liquid.

[0020] Example 3 A pure plant compound liquid based on wart removal and repair of the skin's stratum corneum barrier is composed of the following raw materials in parts by weight: 15 parts purslane extract, 10 parts Brucea javanica extract, 12 parts honeysuckle extract, 8 parts licorice extract, 18 parts aloe vera extract, 5 parts hyaluronic acid, 6 parts glycerin, 2 parts menthol, and 80 parts deionized water.

[0021] Its preparation method includes the following steps: (1) Raw material pretreatment: Weigh each raw material according to the above weight proportions. The preparation method of purslane extract is as follows: Take fresh purslane, wash and crush it, add 8 times the weight of 80% ethanol solution, reflux at 60℃ for 3 hours, extract twice, combine the extracts, and concentrate under reduced pressure until there is no alcohol taste. The preparation method of Brucea javanica extract is as follows: Take Brucea javanica fruit, remove the shell and crush it, add 10 times the weight of 75% ethanol solution, ultrasonically extract for 60 minutes at 50℃, extract twice. The extracts were combined, filtered, and concentrated under reduced pressure. Honeysuckle extract and licorice extract were prepared by water extraction and alcohol precipitation: the corresponding plant materials were taken, washed, crushed, and 12 times their weight of deionized water were added. The mixture was boiled and extracted for 2 hours, and the extraction was repeated twice. The extracts were combined and concentrated to a paste with a relative density of 1.20 (60℃). Ethanol was added to a volume fraction of 70%, and the mixture was allowed to stand for 24 hours. The mixture was filtered, and the filtrate was concentrated under reduced pressure until no alcohol odor was detected. Aloe extract was a concentrated aloe extract with a solid content of 30%. (2) Preparation of base solution: Add deionized water to the reaction vessel, heat to 50°C, stir evenly, add hyaluronic acid and glycerin in sequence, and continue stirring for 25 minutes until the raw materials are completely dissolved to obtain the base solution; (3) Addition of active ingredients: Keep the temperature of the reactor at 45°C, and add purslane extract, croton extract, honeysuckle extract, licorice extract and aloe extract to the base solution in sequence while stirring at a speed of 200 r / min for 40 minutes. (4) Flavoring and homogenization: Add menthol to the above mixture and continue stirring for 15 minutes. Then, use a high-pressure homogenizer to homogenize three times at a pressure of 30 MPa for 8 minutes each time to obtain a homogenized liquid. (5) Filtration and sterilization: Cool the homogenized liquid to room temperature, filter it through a 0.45μm filter membrane, and then sterilize it with ultraviolet sterilization for 20 minutes to obtain pure plant compound liquid.

[0022] Comparative Example 1 A pure plant-based wart removal liquid, the raw materials and their weight parts are as follows: 8 parts of Brucea javanica extract, 9 parts of Lonicera japonica extract, 4.5 parts of glycerin, 1.2 parts of menthol, and 65 parts of deionized water (omitting Portulaca oleracea extract, Glycyrrhiza uralensis extract, Aloe vera extract, and hyaluronic acid). The preparation method is the same as in Example 2 of this invention, except that the missing ingredients are not added.

[0023] Comparative Example 2 A pure plant-based repair solution, comprising the following raw materials and parts by weight: 6 parts licorice extract, 14 parts aloe vera extract, 3.5 parts hyaluronic acid, 4.5 parts glycerin, and 65 parts deionized water (omitting purslane extract, croton extract, honeysuckle extract, and menthol). The preparation method is identical to that of Example 2 of this invention, except that the missing components are not added.

[0024] Comparative Example 3 Commercially available chemical wart remover (main ingredient: 20% salicylic acid).

[0025] 1. Experimental Subjects: 180 volunteers diagnosed with common warts, aged 18-55 years, were randomly divided into 6 groups of 30 each. Each group received one of the following treatments: Compound Solution 1 (Experimental Group 1), Compound Solution 2 (Experimental Group 2), Compound Solution 3 (Experimental Group 3), Wart Removal Solution (Control Group 1) (Comparative Example 1), Repair Solution (Control Group 2) (Comparative Example 2), and Commercially Available Chemical Wart Removal Agent (Control Group 3). All volunteers had 1-3 warts, with a diameter of 0.3-1.0 cm. They had not received any other wart removal treatments one month prior to the experiment, had no history of serious skin diseases or allergies, and signed informed consent forms.

[0026] 2. Experimental method: Experimental groups 1-3 and control groups 1 and 2 applied the corresponding product once in the morning and once in the evening, applying it to the wart and the surrounding 1cm of skin, and gently massaging for 30 seconds until fully absorbed; control group 3 used it according to the instructions, applying it to the wart once a day, avoiding contact with the surrounding normal skin. The experimental period was 4 weeks. The following indicators were recorded at the end of the first, second, third and fourth weeks of the experiment: (1) Wart shedding (partial shedding: wart volume reduced by ≥30%; complete shedding: wart completely disappeared and skin returned to smoothness); (2) Skin barrier related indicators (transepidermal water loss (TEWL), detected by a skin water loss tester; stratum corneum water content, detected by a skin water content tester, all of which were averaged at 3 different sites on normal skin 1 cm around the wart); (3) Skin irritation reaction (graded as none, mild, moderate and severe; mild: transient redness and itching, which subsided on its own within 1 week; moderate: persistent redness and stinging, requiring topical soothing products; severe: peeling, ulceration and infection, requiring discontinuation of medication).

[0027] (1) Comparison of wart shedding effects: After the experiment, the complete wart shedding rates of experimental groups 1-3 were 86.7%, 93.3%, and 90.0%, respectively, all significantly higher than those of control group 1 (66.7%) and control group 3 (86.7%). No warts shed in control group 2. Among them, experimental group 2 had the highest complete shedding rate and the shortest wart shedding cycle. The specific shedding situation is shown in Table 1 below: Table 1 Comparison of wart shedding in each group (Unit: person, %) Group Partly dropped out (person) at the end of the 1st week Partly dropped out (person) at the end of the 2nd week Partly dropped out (person) at the end of the 3rd week Completely dropped out (person) at the end of the 4th week Complete drop-out rate Average drop-out period (days) Example 1) 6 10 6 26 86.7% 22.5±3.2 Example 2) 8 12 5 28 93.3% 19.8±2.8 Example 3) 7 11 6 27 90.0% 21.2±3.0 Comparative Example 1) 3 7 8 20 66.7% 26.8±4.1 Comparative Example 2) 0 0 0 0 0% - Comparative Example 3) 10 9 4 26 86.7% 20.5±3.5 2) Comparison of skin barrier repair effects: Before the experiment, there were no significant differences in TEWL values ​​and stratum corneum moisture content among the volunteers in each group (P>0.05); after 4 weeks of experiment, the TEWL values ​​of all experimental groups decreased significantly, and the stratum corneum moisture content increased significantly, with experimental group 2 showing the best effect; the TEWL values ​​of control groups 1 and 3 were higher than those of the experimental groups, while the stratum corneum moisture content was lower than that of the experimental groups; although control group 2 showed a repair effect, it did not have a wart-removing effect. Specific data are shown in Table 2 below: Table 2 Comparison of skin barrier indices among groups (at the end of week 4 of the experiment, mean ± standard deviation) Group TEWL value (g / (m 2 ·h) before experiment TEWL values (g / (m 2 ·h) after the experiment Stratum corneum moisture content (%) before experiment Stratum corneum moisture content (%) after experiment Example 1 28.6±3.8 17.5±2.5 32.1±2.9 39.8±3.2 Example 2 28.3±3.6 15.2±2.3 31.8±3.0 42.5±3.1 Example 3 28.5±3.7 16.3±2.4 32.0±2.8 41.2±3.3 Comparative Example 1 28.4±3.5 22.6±3.5 31.9±2.7 35.8±2.8 Comparative Example 2 28.2±3.4 16.8±2.7 31.7±2.6 40.2±3.4 Comparative Example 3 28.7±3.6 25.3±4.1 32.2±2.9 32.6±3.0 (3) Comparison of skin irritation: The incidence of irritation in experimental groups 1-3 was 10.0%, 6.7%, and 13.3%, respectively, all of which were mild irritation, with no moderate or severe irritation; the incidence of irritation in control group 1 was 20.0%, control group 2 had no irritation, and the incidence of irritation in control group 3 was 46.7%, with 3 people experiencing moderate irritation. The specific details are shown in Table 3 below: Table 3 Comparison of skin irritation in each group (unit: person, %) Group Number of test persons No irritation (person) Mild irritation (person) Moderate irritation (person) Severe irritation (person) Irritation incidence Example 1 30 27 3 0 0 10.0% Example 2 30 28 2 0 0 6.7% Example 3 30 26 4 0 0 13.3% Example 1 30 24 6 0 0 20.0% Comparative Example 2 30 30 0 0 0 0% Comparative Example 3 30 16 11 3 0 46.7% As shown in Tables 1-3, the compound solutions of Examples 1-3 all have significant wart removal effects, with a complete shedding rate of 86.7%-93.3%. Among them, Example 2 (optimal ratio) has the best effect, with a complete shedding rate of 93.3% and the shortest average shedding period (19.8 days), which is better than the pure plant wart removal solution of Comparative Example 1 and the commercially available chemical wart removal agent of Comparative Example 3; (2) Experimental groups 1-3 can effectively repair the damaged skin stratum corneum barrier, significantly reduce the TEWL value, and increase the stratum corneum moisture content. The repair effect is better than that of control group 1 and control group 3, and close to that of control group 2 pure plant repair solution; (3) The skin irritation rate of experimental groups 1-3 is only 6.7%-13.3%, and all are mild irritation. The safety is much higher than that of control group 3 commercially available chemical wart removal agent (irritation rate 46.7%).

[0028] It should be noted that, in this document, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0029] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A pure plant compound solution for repairing skin horny layer barrier based on wart removal, characterized in that, It is composed of the following raw materials in parts by weight: 8-15 parts of purslane extract, 5-10 parts of Brucea javanica extract, 6-12 parts of honeysuckle extract, 4-8 parts of licorice extract, 10-18 parts of aloe vera extract, 2-5 parts of hyaluronic acid, 3-6 parts of glycerin, 0.5-2 parts of menthol, and 50-80 parts of deionized water.

2. The pure plant compound solution based on wart removal and skin horny layer barrier repair according to claim 1, characterized in that, It is composed of the following raw materials in parts by weight: 10-12 parts of purslane extract, 7-9 parts of Brucea javanica extract, 8-10 parts of honeysuckle extract, 5-7 parts of licorice extract, 12-16 parts of aloe vera extract, 3-4 parts of hyaluronic acid, 4-5 parts of glycerin, 1-1.5 parts of menthol, and 60-70 parts of deionized water.

3. The pure plant compound solution for repairing skin horny layer barrier based on wart removal according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: 11 parts purslane extract, 8 parts Brucea javanica extract, 9 parts honeysuckle extract, 6 parts licorice extract, 14 parts aloe vera extract, 3.5 parts hyaluronic acid, 4.5 parts glycerin, 1.2 parts menthol, and 65 parts deionized water.

4. The pure plant compound solution based on wart-removing and skin horny layer barrier repairing according to any one of claims 1-3, characterized in that, The purslane extract is prepared by the following method: Fresh purslane is taken, washed, crushed, and then 5-8 times its weight of 70%-80% ethanol solution is added. The mixture is refluxed at 50-60℃ for 2-3 hours, and extracted twice. The extracts are combined and concentrated under reduced pressure until there is no alcohol odor to obtain the purslane extract.

5. The pure plant compound solution based on wart-removing and skin horny layer barrier repairing according to any one of claims 1-3, characterized in that, The extract of Brucea javanica is prepared by the following method: take Brucea javanica fruit, remove the shell and crush it, add 6-10 times the weight of 60%-75% ethanol solution, extract ultrasonically for 30-60 minutes, the extraction temperature is 40-50℃, extract twice, combine the extracts, filter and concentrate under reduced pressure to obtain Brucea javanica extract.

6. The pure plant compound solution based on wart removal and skin horny layer barrier repair according to any one of claims 1-3, characterized in that, The honeysuckle extract and licorice extract were prepared by water extraction and alcohol precipitation. The specific steps were as follows: take the corresponding plant raw materials, wash and crush them, add 8-12 times the weight of deionized water, boil and extract for 1-2 hours, extract twice, combine the extracts, concentrate to an extract with a relative density of 1.10-1.20, add ethanol to an ethanol volume fraction of 60%-70%, let stand for 12-24 hours, filter, concentrate the filtrate under reduced pressure until there is no alcohol odor, and obtain the corresponding extracts.

7. The pure plant compound solution based on wart removal and skin horny layer barrier repair according to any one of claims 1-3, characterized in that, The aloe extract is a concentrated liquid obtained by centrifuging, filtering and concentrating fresh aloe juice, with a solid content of 20%-30%.

8. A method of preparing a pure plant-based complex solution for repairing the barrier of the stratum corneum of the skin based on wart removal according to any one of claims 1-7, characterized by, Includes the following steps: (1) Raw material pretreatment: Weigh out the following ingredients by weight: purslane extract, croton extract, honeysuckle extract, licorice extract, aloe extract, hyaluronic acid, glycerin, menthol, and deionized water, and set aside. (2) Preparation of base solution: Add deionized water to the reaction vessel, heat to 40-50℃, stir evenly, add hyaluronic acid and glycerin in sequence, and continue stirring for 15-25 minutes until the raw materials are completely dissolved to obtain the base solution; (3) Addition of active ingredients: Keep the temperature of the reactor at 35-45℃, and add purslane extract, croton extract, honeysuckle extract, licorice extract and aloe extract to the base solution in sequence. Stir while adding, and the stirring speed is 150-200r / min. Stir for 30-40 minutes to make the active ingredients fully mixed. (4) Flavoring and homogenizing: adding menthol into the mixed solution, continuing to stir for 10-15 minutes, and then homogenizing 2-3 times by using a high-pressure homogenizer under a pressure of 20-30 MPa, each time for 5-8 minutes, to obtain a homogenized solution; (5) Filtering and sterilizing: cooling the homogenized solution to room temperature, filtering through a 0.45 μm filter membrane to remove impurities, and then sterilizing by using a UV sterilization method for 15-20 minutes to obtain a pure plant compound solution.