A thrombin device

Abstract

The application belongs to the field of thrombin apparatus and equipment, and relates to a thrombin apparatus, which comprises a frame structure, a reaction cup assembly, a reagent assembly, a sample assembly, a suction head assembly, an incubation and detection assembly and a mechanical arm group. The components of the application are integrated and installed on the mounting plate of the frame structure, the reaction cup assembly adopts gear and rack driving to realize automatic transfer of the cup rack, the reagent assembly realizes accurate temperature control of two kinds of reagents through a heating belt and a refrigeration module respectively, and the sample assembly and the suction head assembly adopt a pull-out structure, which is convenient for loading and unloading consumables. The application is compact in structure, convenient in operation and accurate in detection, and can be widely applied to thrombin detection scenes of medical institutions and scientific research laboratories at all levels.

Description

Technical Field

[0001] This invention belongs to the technical field of thrombin instruments and equipment, and relates to a thrombin device. Background Technology

[0002] Thrombin testing is a key technology for the clinical diagnosis of thrombotic diseases, preoperative coagulation function screening, and biomedical research. With the increasing demands for medical testing, the market requires thrombin testing equipment to be compact, easy to operate, and versatile. However, existing thrombin testing equipment typically suffers from the following drawbacks: a fragmented overall layout with independently configured functional components, resulting in bulky instruments that occupy significant laboratory or testing space, making them unsuitable for space-constrained locations such as community hospitals and small research laboratories.

[0003] Therefore, developing a compact and easy-to-operate thrombin device has become an urgent technical problem to be solved in this field. Summary of the Invention

[0004] The purpose of this invention is to solve the above-mentioned problems and provide a thrombin device.

[0005] To achieve the above objectives, the present invention provides a thrombin device, including a frame structure, a mounting plate on the frame structure, and a reaction cup assembly, a reagent assembly, a sample assembly, a pipette tip assembly, an incubation and detection assembly, and a robotic arm assembly mounted on the mounting plate.

[0006] Furthermore, the reaction cup assembly includes a base fixedly mounted on a mounting plate, and a guide block is provided on the base;

[0007] The reaction cup assembly also includes a support plate, a positioning plate, and a cup holder for placing the reaction cup. A guide plate is provided on the lower side of the support plate, which slides in conjunction with a guide block.

[0008] Furthermore, a drive motor is provided on the lower side of the base, and the output end of the drive motor passes through the base and is connected to a gear. A rack is also provided on the lower side of the support plate to mesh with the gear.

[0009] Furthermore, the reagent assembly includes a support column mounted on a mounting plate, a worktable mounted on the upper side of the support column, a first reagent holder and a second reagent holder on the worktable, the first reagent holder being equipped with a heating band, and a cooling module being equipped on the lower side of the second reagent holder.

[0010] Furthermore, the sample assembly includes a mounting base and a movable plate disposed on the mounting base, the movable plate being provided with a sample holder, and a pull plate being provided at one end of the movable plate;

[0011] The mounting base is provided with a guide hole, and the movable plate has a sliding block that passes through the guide hole. There is also a limit seat on the lower side of the mounting base.

[0012] Furthermore, the suction head assembly includes a slide mounted on a mounting plate and a slide plate that slides in cooperation with the slide plate. One end of the slide plate is provided with a handle, and a suction head holder is provided on the slide plate for placing the suction head.

[0013] Furthermore, the incubation detection component includes an incubation component and a detection component. The incubation component includes an incubation tray with multiple incubation holes, and a rotating belt pair for driving the incubation tray to rotate is provided below the incubation tray.

[0014] Furthermore, the detection assembly includes a detection disc with multiple detection holes, and a second rotary belt pair for driving the detection disc to rotate is located below the detection disc;

[0015] Two sets of optical detectors are installed around the outer perimeter of the detection plate, and a baffle is installed above the detection plate with two sample loading and detection ports.

[0016] Furthermore, the robotic arm assembly includes an X-axis moving assembly, a Y-axis moving assembly mounted on the X-axis moving assembly, a Z-axis moving liquid suction device mounted on the Y-axis moving assembly, and a Z-axis moving gripper.

[0017] The beneficial effects of this invention are as follows:

[0018] The thrombin device of the present invention integrates the reaction cup assembly, reagent assembly, sample assembly, pipette tip assembly, incubation and detection assembly, and robotic arm assembly on the same mounting plate. The components are arranged in a compact and reasonable manner, which greatly reduces the overall size of the device and makes it more adaptable.

[0019] The thrombin device of this invention features a reaction cup assembly with a rack and pinion driven sliding structure, allowing for rapid transfer of the cup holder to the loading or working station. Both the sample and pipette tip assemblies are designed with a pull-out structure, allowing operators to easily load and unload the sample holder and tip holder by pulling a pull plate or handle, eliminating the need for complex positioning and adjustments. The reagent assembly is equipped with heating belts and cooling modules to meet the temperature requirements of different reagents, achieving precise temperature control without manual adjustment. This convenient design of each component significantly reduces consumable replenishment time and improves overall testing efficiency. Attached Figure Description

[0020] Figure 1 A schematic perspective view of a thrombin device according to an embodiment of the present invention;

[0021] Figure 2 A schematic front view of a thrombin device according to an embodiment of the present invention;

[0022] Figure 3 This schematic diagram illustrates the structural layout of a reaction cup assembly, reagent assembly, sample assembly, pipette tip assembly, and incubation detection assembly according to an embodiment of the present invention.

[0023] Figure 4 A schematic perspective view of a reaction cup assembly according to an embodiment of the present invention;

[0024] Figure 5 A schematic front view of a reaction cup assembly according to an embodiment of the present invention;

[0025] Figure 6 Schematic representation of a three-dimensional reaction cup assembly according to an embodiment of the present invention. Figure 2 ;

[0026] Figure 7 A schematic perspective view of a reagent assembly according to one embodiment of the present invention;

[0027] Figure 8 A schematic perspective view of a sample component according to an embodiment of the present invention;

[0028] Figure 9 Schematic representation of a three-dimensional sample assembly according to an embodiment of the present invention Figure 2 ;

[0029] Figure 10 illustrative representation Figure 9 Enlarged view of section A in the middle;

[0030] Figure 11 Schematic representation of a three-dimensional sample assembly according to an embodiment of the present invention Figure 3 ;

[0031] Figure 12 A schematic perspective view of a suction head assembly according to an embodiment of the present invention;

[0032] Figure 13 A schematic perspective view of an incubation detection assembly according to one embodiment of the present invention;

[0033] Figure 14 Schematic representation of an incubation detection component according to an embodiment of the present invention. Figure 2 .

[0034] The meanings of the numbers in the attached diagram are as follows:

[0035] 1. Frame structure; 11. Mounting plate; 2. Reaction cup assembly; 3. Reagent assembly; 4. Sample assembly; 5. Pipe tip assembly; 6. Incubation and detection assembly; 7. Robotic arm assembly; 21. Base; 22. Guide block; 23. Support plate; 24. Positioning plate; 25. Cup holder; 26. Reaction cup; 27. Guide plate; 28. Drive motor; 29. ​​Gear; 210. Rack; 31. Support column; 32. Worktable; 33. First reagent holder; 34. Second reagent holder; 35. Heating belt; 36. Cooling module; 41. Mounting base; 411. Guide hole; 42. Transfer... 43. Moving plate; 44. Sample rack; 45. Pull plate; 46. Sliding block; 57. Limiting seat; 58. Slide seat; 59. Slide plate; 50. Handle; 51. Suction tip holder; 62. Incubation assembly; 63. Detection assembly; 64. Incubation tray; 65. Incubation hole; 66. Rotary belt pair; 67. Detection tray; 68. Detection hole; 69. Second rotary belt pair; 60. Optical detector; 61. Baffle; 62. Sample dispensing and detection port; 71. X-axis moving assembly; 72. Y-axis moving assembly; 73. Z-axis moving aspirator; 74. Z-axis moving gripper. Detailed Implementation

[0036] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly described below. Obviously, the drawings described below are merely some embodiments of the present invention, and those skilled in the art can obtain other drawings based on these drawings without creative effort.

[0037] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. The embodiments cannot be described in detail here, but the embodiments of the present invention are not limited to the following embodiments.

[0038] Combination Figures 1-3 As shown, the present invention provides a thrombin device, including a frame structure 1, a mounting plate 11 in the middle of the frame structure 1, and a reaction cup assembly 2, a reagent assembly 3, a sample assembly 4, a pipette tip assembly 5, an incubation and detection assembly 6, and a robotic arm assembly 7 mounted on the mounting plate 11.

[0039] Combination Figures 3-6As shown, according to one embodiment of the present invention, the reaction cup assembly 2 includes a base 21 fixedly mounted on a mounting plate 11, and a guide block 22 is provided on the base 21. The reaction cup assembly 2 also includes a support plate 23, a positioning plate 24 is provided on the support plate 23, and a cup holder 25 is provided on the positioning plate 24 for placing the reaction cup 26. A guide plate 27 is provided on the lower side of the support plate 23, which slides in cooperation with the guide block 22. A drive motor 28 is provided on the lower side of the base 21, and a gear 29 is connected to the output end of the drive motor 28 through the base 21. A rack 210 is also provided on the lower side of the support plate 23, which meshes with the gear 29.

[0040] The reaction cup assembly of the present invention, through the above-described structural configuration, allows the drive motor 28 to rotate the gear 29. Due to the meshing of the rack 210 and the gear 29, the positioning plate 24 can be moved. Therefore, the positioning plate 24 can be moved to the loading station, the cup holder 25 filled with reaction cups 26 can be placed on the positioning plate 24, and then the drive motor 28 can be activated to move the cup holder 25 to the working station.

[0041] Combination Figure 3 and Figure 7 As shown, the reagent assembly 3 of the present invention includes a support column 31 mounted on a mounting plate 11. A workbench 32 is mounted on the upper side of the support column 31. A first reagent holder 33 and a second reagent holder 34 are provided on the workbench 32. The first reagent holder 33 is provided with a heating band 35, and the second reagent holder 34 is provided with a cooling module 36 on its lower side. According to one embodiment of the present invention, reagent R2 and reagent R1 are respectively placed in the first reagent holder 33 and the second reagent holder 34, wherein the temperature of reagent R1 is 15°C and the temperature of reagent R2 is 37°C. The heating band 35 and the cooling module 36 can effectively maintain the temperature of reagent R1 and reagent R2.

[0042] Combination Figure 3 , Figures 8-11 As shown, according to one embodiment of the present invention, the sample assembly 4 includes a mounting base 41 and a movable plate 42 disposed on the mounting base 41. A sample holder 43 is provided on the movable plate 42 for placing samples. A pull plate 44 is provided at one end of the movable plate 42. An opening is provided on the frame structure 1, through which the pull plate 44 can be pulled outwards. After the sample is placed, the pull plate 44 is pushed back in. Specifically, in this embodiment, a guide hole 411 is provided on the mounting base 41, and a sliding block 45 is provided on the lower side of the movable plate 42, passing through the guide hole 411. A limiting seat 46 is also provided on the lower side of the mounting base 41. When the pull plate 44 is pulled, the movable plate 42 moves outwards, and the sliding block 45 moves along the guide hole 411.

[0043] Combination Figure 3 and Figure 12As shown, according to one embodiment of the present invention, the suction head assembly 5 includes a slide 51 mounted on a mounting plate 11 and a slide plate 52 that slidably engages with the slide 51. One end of the slide plate 52 is provided with a handle 53, and a suction head holder 54 is provided on the slide plate 52 for holding suction heads. The frame structure 1 has an opening adapted to the handle 53. Pulling the handle 53 can pull the slide plate 52 out of the slide 51, then the suction head holder 54 can be filled with suction heads, and pushing the handle 53 back to its original position completes the loading process.

[0044] Combination Figure 3 , Figure 13 and Figure 14 As shown, according to one embodiment of the present invention, the incubation detection assembly 6 includes an incubation assembly 61 and a detection assembly 62. The incubation assembly 61 includes an incubation disk 611 with a plurality of incubation holes 612. A rotating belt assembly 613 for driving the incubation disk 611 to rotate is located below the incubation disk 611. The detection assembly 62 includes a detection disk 621 with a plurality of detection holes 622. A second rotating belt assembly 623 for driving the detection disk 621 to rotate is located below the detection disk 621. Two sets of optical detectors 624 are provided on the outer periphery of the detection disk 621. A baffle 625 is provided above the detection disk 621, and two sample loading and detection ports 626 are provided on the baffle 625.

[0045] Combination Figure 1 and Figure 2 As shown, according to one embodiment of the present invention, the robotic arm assembly 7 includes an X-axis moving assembly 71, a Y-axis moving assembly 72 mounted on the X-axis moving assembly 71, a Z-axis moving liquid suction device 73 mounted on the Y-axis moving assembly 72, and a Z-axis moving gripper 74.

[0046] The working process of the thrombin device of the present invention is as follows:

[0047] First, as described above, load the reaction cup, reagents, pipette tips, and sample to be tested into their positions. Then, the robotic arm assembly 7 moves the Z-axis moving gripper 74 to pick up the reaction cup 26 from the reaction cup assembly 2 and place it in the incubation tray 611. The robotic arm assembly 7 then moves the Z-axis moving pipette 73 to the pipette tip holder 54 to load the pipette tip, then moves to the sample holder 43 to aspirate the sample, and then moves back to the incubation tray 611 to drop the aspirated sample into the reaction cup 26. Afterward, the robotic arm assembly 7 moves back to the pipette tip holder 54 to replace the pipette tip, then moves to the reagent assembly to aspirate reagent R1 and drop it into the reaction cup containing the sample for incubation. At this time, the incubation tray 611 rotates, ensuring sample incubation while simultaneously rotating the incubation tray 611 to the next incubation well 612 position, repeating the above operation to incubate the next sample.

[0048] After the incubation period, reagent R2 is drawn into the reaction cup by the Z-axis moving aspirator 73. Then, the reaction cup is grasped by the Z-axis moving gripper 74 and placed in the detection tray 621. The detection tray rotates, and the fluorescence from the reaction cup is received by the optical detector 624 and transmitted to the analysis system for data analysis. In this invention, two sets of optical detectors 624 are provided on the outer periphery of the detection tray 621, and a baffle 625 is provided above the detection tray 621, with two sample dispensing ports 626 on the baffle 625. This arrangement ensures that samples placed at intervals on the detection tray are received by the two sets of optical detectors 624 respectively. Of course, it is easy to understand that the above-mentioned settings of the two sample dispensing ports 626 and the two sets of optical detectors 624 can be adjusted according to actual needs, considering factors such as reaction time and tray rotation speed, for example, adjusting the interval between the two sample dispensing ports and the positions of the two sets of optical detectors.

[0049] The above description is merely one embodiment of the present invention and is not intended to limit the invention. Those skilled in the art will recognize that the present invention can be modified and varied in various ways. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A thrombin device, characterized in that, It includes a frame structure (1), which is equipped with a mounting plate (11). The mounting plate (11) is equipped with a reaction cup assembly (2), a reagent assembly (3), a sample assembly (4), a pipette tip assembly (5), an incubation detection assembly (6), and a robotic arm assembly (7). The reaction cup assembly (2) includes a base (21) fixedly mounted on a mounting plate (11), and a guide block (22) is provided on the base (21); The reaction cup assembly (2) also includes a support plate (23), a positioning plate (24) is provided on the support plate (23), a cup holder (25) is provided on the positioning plate (24), the cup holder (25) is used to place the reaction cup (26), and a guide plate (27) is provided on the lower side of the support plate (23) and slides in cooperation with the guide block (22); A drive motor (28) is provided on the lower side of the base (21). The output end of the drive motor (28) passes through the base (21) and is connected to a gear (29). A rack (210) is also provided on the lower side of the support plate (23) to mesh with the gear (29). The reagent assembly (3) includes a support column (31) mounted on a mounting plate (11), a workbench (32) is mounted on the upper side of the support column (31), a first reagent seat (33) and a second reagent seat (34) are provided on the workbench (32), the first reagent seat (33) is provided with a heating belt (35), and the second reagent seat (34) is provided with a cooling module (36) on the lower side. The sample assembly (4) includes a mounting base (41) and a movable plate (42) disposed on the mounting base (41). The movable plate (42) is provided with a sample rack (43) and a pull plate (44) is provided at one end of the movable plate (42). The mounting base (41) is provided with a guide hole (411), the movable plate (42) is provided with a sliding block (45) passing through the guide hole (411), and the mounting base (41) is also provided with a limiting seat (46) on the lower side. The suction head assembly (5) includes a slide (51) mounted on a mounting plate (11) and a slide plate (52) that slides with the slide (51). One end of the slide plate (52) is provided with a handle (53), and a suction head holder (54) is provided on the slide plate (52) for placing the suction head. The incubation detection component (6) includes an incubation component (61) and a detection component (62). The incubation component (61) includes an incubation tray (611), which has multiple incubation holes (612). A rotating belt pair (613) for driving the incubation tray (611) to rotate is provided below the incubation tray (611). The detection assembly (62) includes a detection disk (621), which has multiple detection holes (622) and a second rotating belt pair (623) for driving the detection disk (621) to rotate is provided below the detection disk (621). Two sets of optical detectors (624) are provided on the outer periphery of the detection plate (621), and a baffle (625) is provided above the detection plate (621). Two sample addition and detection ports (626) are provided on the baffle (625).

2. The thrombin device according to claim 1, characterized in that, The robotic arm assembly (7) includes an X-axis moving assembly (71), a Y-axis moving assembly (72) mounted on the X-axis moving assembly (71), a Z-axis moving suction device (73) mounted on the Y-axis moving assembly (72), and a Z-axis moving gripper (74).

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