Mosquito repelling composition and application thereof

Abstract

The invention discloses a mosquito repelling composition and application thereof. The mosquito repelling composition provided by the invention is prepared from the following components: caryophyllene oxide, eudesmol, linalool, alpha-terpilenol and delta-juniper according to a weight ratio of (1 to 10): (1 to 12): (1 to 10): (1 to 10): (1 to 10). After the caryophyllene oxide, the eudesmol, the linalool, the alpha-terpilenol and the delta-juniper are compounded, the components have a synergistic effect and have remarkable mosquito-repelling activity, the effect is superior to that of independent use or pairwise superposition use of the components, and the mosquito-repelling effect is further improved while the concentration and the dosage of the components are reduced. The composition provided by the invention is remarkable in mosquito repelling effect, safe in component source, sufficient in raw materials, low in toxic and side effects, green, healthy, simple to prepare and easy to industrialize, and a method means is provided for preparing more efficient, green and safe plant source mosquito repelling products.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical technology. More specifically, it relates to a mosquito repellent composition and its application. Background Technology

[0002] Mosquitoes are vectors for many viruses, such as yellow fever, dengue fever, and Zika, which are spreading not only in subtropical regions but also globally. Therefore, mosquitoes have become a threat to global public safety. Developing safe and effective mosquito repellents to prevent mosquito bites and the spread of diseases is crucial for maintaining public health security.

[0003] Currently, the most common mosquito repellents are chemically synthesized repellents containing DEET, which remains widely used as a daily mosquito repellent product. However, studies have found that DEET has skin toxicity; large-area application can lead to poisoning, and direct use by children can even cause toxic encephalopathy. Furthermore, research indicates that DEET has potential ecotoxicity and can pollute the environment. In recent years, with the emergence of problems with chemically synthesized mosquito repellents, plant-based mosquito repellents with low toxicity and environmental friendliness have gradually gained widespread attention from researchers. Since the 11th century, my country has been using aromatic plants such as mugwort and catnip to repel mosquitoes. Natural plants contain a large number of natural active ingredients that can not only prevent and treat diseases but also repel and even kill mosquitoes; plant-based mosquito repellents derived from natural plants are more environmentally friendly, abundant in resources, and less irritating to the skin. Therefore, finding and developing plant-based mosquito repellents has become a current research hotspot.

[0004] However, currently there are few plant-derived, green, and safe mosquito repellent products. Most products directly use plant extracts for mosquito repellency, such as the Mikania micrantha mosquito repellent disclosed in Chinese Patent 201410310909.7, whose active ingredients have not been fully developed and utilized, resulting in limited mosquito-repelling effects. Therefore, it is necessary to develop more efficient, green, and safe plant-derived mosquito repellent products to repel mosquitoes and prevent infection after bites. Summary of the Invention

[0005] The technical problem to be solved by this invention is to overcome the defects of existing chemical mosquito repellents and the shortcomings of green and safe plant-based mosquito repellent products, and to provide a mosquito repellent composition and its application.

[0006] The purpose of this invention is to provide a mosquito repellent composition.

[0007] Another object of the present invention is to provide the application of the mosquito repellent composition.

[0008] Another object of the present invention is to provide a mosquito repellent product.

[0009] Another object of the present invention is to provide a mosquito repellent liquid.

[0010] The above-mentioned objective of this invention is achieved through the following technical solution:

[0011] The present invention provides a mosquito repellent composition comprising the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (1-10): (1-12): (1-10): (1-10): (1-10).

[0012] This invention analyzed 11 active ingredients in *Mikania micrantha* extract, among which caryophyllene oxide exhibited the best mosquito-repellent activity, while o-cymene showed the worst. δ-juniperene alone showed poor mosquito-repellent activity, but its mosquito-repellent activity was significantly enhanced when combined with specific components. When caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were combined, a synergistic effect was observed among the components, resulting in a composition with significant mosquito-repellent activity superior to that of individual components or their combination. This combination further enhanced the mosquito-repellent effect while reducing the concentration and dosage of each component. The composition provided by this invention has a significant mosquito-repellent effect, its components are safe to obtain, have extremely low toxicity and side effects, are green and healthy, the raw materials are abundant, readily available, and inexpensive, the preparation method is simple, and it is easy to industrialize. This provides more methods and means for preparing efficient, green, and safe plant-derived mosquito-repellent products.

[0013] Preferably, the composition contains the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (3-10): (1-12): (3-10): (1-10): (1-10).

[0014] More preferably, the composition contains the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (5-10): (1-10): (3-10): (1-8): (1-8).

[0015] More preferably, the composition contains the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (5-10): (3-10): (3-10): (1-8): (1-8).

[0016] More preferably, the composition contains the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (7-10): (3-10): (3-9): (1-8): (1-8).

[0017] More preferably, the composition contains the following components in the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = 9.8: 9.9: 8.6: 7.9: 7.8.

[0018] Furthermore, the composition can be prepared by uniformly mixing the various component raw materials.

[0019] This invention provides the use of mosquito repellent compositions in repelling mosquitoes.

[0020] This invention provides the use of mosquito repellent compositions in the preparation of mosquito repellent products.

[0021] The present invention provides a mosquito repellent product comprising the above-mentioned mosquito repellent composition.

[0022] Furthermore, the product is a mosquito repellent liquid, mosquito repellent patch, mosquito repellent cream, or mosquito repellent gel.

[0023] The present invention also provides a mosquito repellent liquid, which is prepared from the above-mentioned mosquito repellent composition, specifically containing the following components by weight percentage: 1% to 10% caryophyllene oxide, 1% to 12% eucalyptol, 1% to 10% linalool, 1% to 10% α-terpineol, 1% to 10% δ-juniperene, and the balance being solvent.

[0024] Preferably, the mosquito repellent contains the following components by weight percentage: 3%–10% caryophyllene oxide, 1%–12% eucalyptol, 3%–10% linalool, 1%–10% α-terpineol, 1%–10% δ-juniperene, and the balance being solvent.

[0025] More preferably, the mosquito repellent contains the following components by weight percentage: 5%–10% caryophyllene oxide, 1%–10% eucalyptol, 3%–10% linalool, 1%–8% α-terpineol, 1%–8% δ-juniperene, and the balance being solvent.

[0026] More preferably, the mosquito repellent contains the following components by weight percentage: 5%–10% caryophyllene oxide, 3%–10% eucalyptol, 3%–10% linalool, 1%–8% α-terpineol, and 1%–8% δ-juniperene.

[0027] More preferably, the mosquito repellent contains the following components by weight percentage: 7%–10% caryophyllene oxide, 3%–10% eucalyptol, 3%–9% linalool, 1%–8% α-terpineol, and 1%–8% δ-juniperene.

[0028] More preferably, the mosquito repellent contains the following components by weight percentage: 9.8% caryophyllene oxide, 9.9% eucalyptol, 8.6% linalool, 7.9% α-terpineol, and 7.8% δ-juniperene.

[0029] Preferably, the solvent of the mosquito repellent is ethanol.

[0030] The present invention has the following beneficial effects:

[0031] This invention provides a mosquito-repellent composition that combines five components: caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene. This composition exhibits significant mosquito-repellent activity, achieving a repellency rate of 83.20%. While eucalyptol, linalool, α-terpineol, and δ-juniperene show poor mosquito-repellent activity when used individually, combining these components in a specific ratio significantly enhances their activity. The components exhibit a synergistic effect, resulting in a superior effect compared to using any single component or combining them in pairs. This approach further improves the mosquito-repellent effect while reducing the required concentration and dosage of each component.

[0032] The composition provided by this invention has safe, green, and healthy components with extremely low toxicity and side effects. The raw materials are abundant, easy to obtain, simple to prepare, inexpensive, and easy to industrialize. It has a significant mosquito-repelling effect and provides more methods and means for preparing efficient, green, and safe plant-based mosquito repellent products. Detailed Implementation

[0033] The present invention will be further illustrated below with reference to specific embodiments, but the embodiments do not limit the present invention in any way. Unless otherwise specified, the reagents, methods, and equipment used in the present invention are conventional reagents, methods, and equipment in this technical field.

[0034] Unless otherwise specified, all reagents and materials used in the following examples are commercially available.

[0035] Example 1: Plant-derived extracts of mosquito-repellent active ingredients

[0036] 1. Component analysis of plant-derived extracts

[0037] Dried Mikania micrantha was pulverized and extracted by steam distillation. The oil layer was collected to obtain Mikania micrantha volatile oil. Subsequently, the components of the Mikania micrantha volatile oil were analyzed by GC-MS. The GC conditions were as follows: HP-5MS capillary column (30m × 0.25mm, 0.25μm), high-purity ammonia (He) as carrier gas, constant pressure mode, injection port temperature 240℃, and the specific temperature program is shown in Table 1; injection volume 0.2μL; mass spectrometry conditions: electron impact (EI ion source), impact source 70eV, ion source temperature 230℃, flow rate 1.0mL / min, full scan monitoring mode, scan range 50–550 amu.

[0038] Table 1. GC-MS Temperature Rise Conditions

[0039]

[0040] GC-MS analysis revealed 11 volatile oil components: caryophyllene oxide, α-terpineol, eucalyptol, β-caryophyllene, trimethylbenzyl alcohol, α-curcumene, δ-juniperene, β-bisabolene, α-humulene, and o-cymene. Further analysis of these 11 components using a Y-type olfactometer test (see Test Example 1 for specific measurement methods) showed that caryophyllene oxide exhibited the strongest mosquito-repellent activity, with 10% caryophyllene oxide achieving a mosquito-repellent rate of up to 72.75%. Components with a mosquito-repellent rate below 30% showed poor activity and almost no mosquito-repellent effect. Specific results are shown in Table 2.

[0041] Table 2. Mosquito repellency rates of different components in 10% Mikania micrantha volatile oil ( n=5)

[0042]

[0043] Note: Different lowercase letters in the table indicate significant differences in mosquito repellency rates among different chemical components (P<0.05).

[0044] 2. Mosquito repellent components

[0045] Caryophyllene oxide was paired with each of the other 10 active ingredients listed in Table 2, and mosquito repellent tests were conducted. The results showed that caryophyllene oxide exhibited enhanced mosquito repellent activity when paired with eucalyptol, linalool, α-terpineol, and δ-juniperene, respectively, compared to caryophyllene oxide alone. However, combinations with the other six ingredients resulted in a decreased mosquito repellent effect. Therefore, caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene, all with mosquito repellent rates exceeding 50%, were selected for subsequent experiments.

[0046] Table 3 shows the statistical results of the mosquito repellency rates of individual mosquito repellent components, caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene, at different concentrations. The results show that the mosquito repellency effects of caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene increase with increasing concentration, but the mosquito repellency effects of higher concentrations of caryophyllene oxide, linalool, and α-terpineol decrease.

[0047] Table 3. Mosquito repellency rates of different concentrations of mosquito repellent composition components ( n=5)

[0048]

[0049]

[0050] Example 2: Mosquito Repellent Composition Formulation

[0051] Based on the results of Example 1, the contents of caryophyllene oxide (A), eucalyptol (B), linalool (C), α-terpineol (D), and δ-juniperene (E) were used as the investigation factors, and the mosquito repellency rate was used as the evaluation index. Five levels were set for each factor, and a uniform design table was used. * 10 (10 8 The experimental design was carried out using the inverse level method, and the experimental factor level table is shown in Table 4.

[0052] Table 4 Factor Level Table

[0053]

[0054] Example 3: Mosquito Repellent Solution

[0055] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 1% caryophyllene oxide + 6% eucalyptol + 7% linalool + 10% α-terpineol + 7% δ-juniperene.

[0056] Example 4: Mosquito Repellent Solution

[0057] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 3% caryophyllene oxide + 12% eucalyptol + 5% linalool + 10% α-terpineol + 3% δ-juniperene.

[0058] Example 5: Mosquito Repellent Solution

[0059] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 5% caryophyllene oxide + 3% eucalyptol + 1% linalool + 7% α-terpineol + 10% δ-juniperene.

[0060] Example 6: Mosquito Repellent Solution

[0061] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 7% caryophyllene oxide, 12% eucalyptol, 10% linalool, 7% α-terpineol, and 5% δ-juniperene.

[0062] Example 7: Mosquito Repellent Solution

[0063] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken by weight percentage, respectively, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 10% caryophyllene oxide + 3% eucalyptol + 7% linalool + 5% α-terpineol + 1% δ-juniperene.

[0064] Example 8: Mosquito Repellent Solution

[0065] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 1% caryophyllene oxide + 8% eucalyptol + 3% linalool + 5% α-terpineol + 10% δ-juniperene.

[0066] Example 9: Mosquito Repellent Solution

[0067] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken by weight percentage, respectively, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 3% caryophyllene oxide + 1% eucalyptol + 1% linalool + 3% α-terpineol + 5% δ-juniperene.

[0068] Example 10: Mosquito Repellent Solution

[0069] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 5% caryophyllene oxide + 8% eucalyptol + 10% linalool + 3% α-terpineol + 1% δ-juniperene.

[0070] Example 11 Mosquito Repellent Solution

[0071] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 7% caryophyllene oxide + 1% eucalyptol + 5% linalool + 1% α-terpineol + 7% δ-juniperene.

[0072] Example 12 Mosquito Repellent Solution

[0073] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken by weight percentage, respectively, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 10% caryophyllene oxide + 6% eucalyptol + 3% linalool + 1% α-terpineol + 3% δ-juniperene.

[0074] Test Example 1: Y-type olfactory instrument test

[0075] Experimental animals: female Aedes albopictus mosquitoes.

[0076] Test conditions: temperature 26℃±1℃, relative humidity 65%±10%.

[0077] Test samples: mosquito repellent combination solutions prepared in Examples 2-13.

[0078] Experimental method: The Y-type olfactory instrument was assembled in the laboratory. It consists of activated carbon tube, gas washing bottle, air flow meter, Y-type glass tube, and vacuum pump connected in sequence by odorless rubber tube and glass stopper. The Y-type glass tube arm is about 16cm long and 3cm in diameter, with an included angle of about 60° between the two tube walls.

[0079] Assemble the Y-shaped olfactory apparatus in the above order. Place the rubber tube at the end of the activated carbon tube outside the window to collect fresh outdoor air. Turn on the vacuum pump, and the outside air will pass through the activated carbon tube sequentially for cleaning. After humidification in the gas washing bottle, the airflow is divided into two streams controlled by an airflow meter, and finally enters the Y-shaped glass tube. After the airflow stabilizes, introduce 10 Aedes albopictus mosquitoes into the Y-shaped tube. After the mosquitoes have adapted to the environment for 5 minutes, use a pipette to draw 10 μL of ethanol and sample solution (i.e., blank group and control group) and drop them onto two 2 cm square filter paper discs. Place the two filter paper discs at the two tube openings of the Y-shaped olfactory apparatus, respectively. Cover the Y-shaped tube with a cardboard box to avoid light interference. Start timing and record the number of mosquitoes on the tube walls at 5 min, 10 min, and 15 min. Calculate the average repulsion rate based on the results, and repeat for 5 sets. After each set of tests, replace the mosquitoes and clean the Y-shaped olfactory apparatus.

[0080] Repellency rate: PR = [(Nc-Nt) / (Nc+Nt)] × 100%, where Nc represents the number of mosquitoes in the blank arm and Nt represents the number of mosquitoes in the treated arm.

[0081] The statistical results of the mosquito repellency of different mosquito repellent combination solutions are shown in Table 5. It shows that the changes in the content of each component in the composition have a significant impact on the mosquito repellency activity. In Examples 7 and 8, the addition of too much δ-juniperene weakens the mosquito repellency effect, while the mosquito repellency effect can be improved after the ratio of each component is properly adjusted.

[0082] Table 5 Results of Test 1 with Y-type olfactory instrument ( n=5)

[0083]

[0084] Test Example 2: Optimal Active Component Ratio

[0085] With mosquito repellency rate as the dependent variable and the contents of caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene as independent variables, the suitable equation obtained through screening is: Y = 0.467 + 2.015A + 35.618AC - 9765.53ABCE + 14869.83ABDE + 16695.39BCDE - 788.147CDE - 10292.2ABCE. The equation has a significance level of P < 0.01, a correlation coefficient R = 1, and F = 4720.328, indicating a good fit and statistical significance, and the equation is valid. Solving the equation using Excel, the optimal combination ratio obtained through screening is: 9.8% caryophyllene oxide + 9.9% eucalyptol + 8.6% linalool + 7.9% α-terpineol + 7.8% δ-juniperene.

[0086] Caryophyllene oxide, eucalyptol, linalool, α-terpineol, and δ-juniperene were taken by weight percentage, respectively, and mixed evenly with ethanol as solvent to prepare an ethanol solution of 9.8% caryophyllene oxide + 9.9% eucalyptol + 8.6% linalool + 7.9% α-terpineol + 7.8% δ-juniperene; and the same test as Test Example 1 (n=10) was conducted to calculate the average mosquito repellency rate.

[0087] The test results showed that the average mosquito repellent rate of the optimal mosquito repellent composition was 83.20%, and the RSD (%) was 8.42, indicating a good mosquito repellent effect.

[0088] Comparative Example 1

[0089] This comparative composition does not contain δ-juniperene. Caryophyllene oxide, eucalyptol, linalool, and α-terpineol were taken by weight percentage and mixed evenly with ethanol as solvent to obtain an ethanol solution of 9.8% caryophyllene oxide + 9.9% eucalyptol + 8.6% linalool + 7.9% α-terpineol. The same test was conducted as in Test Example 1 (n=10), and the average mosquito repellency rate was calculated.

[0090] Comparative Example 2

[0091] Caryophyllene oxide and δ-juniperene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to obtain an ethanol solution of 5.0% caryophyllene oxide + 5.0% δ-juniperene. The same test was carried out as in Test Example 1 (n=5), and the average mosquito repellency rate was calculated.

[0092] Comparative Example 3

[0093] Caryophyllene oxide and α-humulene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to obtain an ethanol solution of 5.0% caryophyllene oxide + 5.0% α-humulene. The same test was carried out as in Test Example 1 (n=5), and the average mosquito repellency rate was calculated.

[0094] Comparative Example 4

[0095] Caryophyllene oxide and A-curcumene were taken separately by weight percentage, and mixed evenly with ethanol as solvent to obtain an ethanol solution of 5.0% caryophyllene oxide + 5.0% A-curcumene. The same test was carried out as in Test Example 1 (n=5), and the average mosquito repellency rate was calculated.

[0096] The average mosquito repellency rate of the composition in Comparative Example 1 was 68.36%, with an RSD of 6.99, which was significantly lower than that of the composition in Test Example 2. The average mosquito repellency rate of the composition in Comparative Example 2 was 64.14%, with an RSD of 8.23. Compared to the mosquito repellency rate of 5% caryophyllene oxide in Example 1, the combination of δ-juniperene in the composition of Comparative Example 2 enhanced the mosquito repellency effect of 5% caryophyllene oxide. The average mosquito repellency rate of the composition in Comparative Example 3 was 40.20%, with an RSD of 19.03. In Comparative Example 3, the mosquito repellency rate was significantly reduced after the caryophyllene oxide was combined with the less active α-humulene. The average mosquito repellency rate of the composition in Comparative Example 4 was 39.33%, and the RSD (%) was 34.71. The mosquito repellency effect of A-curcumene used in Comparative Example 4 was better than that of δ-juniperene, but its mosquito repellency rate decreased after it was compounded with caryophyllene oxide. This shows that it is not necessarily possible to improve the mosquito repellency effect by compounding mosquito repellent components with mosquito repellent activity. Only when specific combinations of mosquito repellent components are compounded can they play a synergistic role and further improve the mosquito repellency effect.

[0097] Furthermore, the mosquito repellent composition provided by this invention is not limited to the preparation of mosquito repellent liquids, but can also be used to prepare other mosquito repellent products, such as mosquito repellent patches, mosquito repellent creams, and mosquito repellent gels, for application to the surface of the human body or clothing to avoid mosquito bites. The mosquito repellent composition provided by this invention has safe and healthy components, significant mosquito repellent effect, abundant raw materials, a simple preparation method, and is easy to industrialize.

[0098] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A mosquito repellent composition, characterized in that, The components contain the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (1-10): (1-12): (1-10): (1-10): (1-10).

2. The mosquito repellent composition according to claim 1, characterized in that, The components contain the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (3-10): (1-12): (3-10): (1-10): (1-10).

3. The mosquito repellent composition according to claim 1, characterized in that, The components contain the following weight ratio: caryophyllene oxide: eucalyptol: linalool: α-terpineol: δ-juniperene = (5-10): (1-10): (3-10): (1-8): (1-8).

4. The use of the mosquito repellent composition according to any one of claims 1 to 3 in repelling mosquitoes.

5. The use of the mosquito repellent composition according to any one of claims 1 to 3 in the preparation of mosquito repellent products.

6. A mosquito repellent product, characterized in that, The mosquito repellent composition comprising any one of claims 1 to 3.

7. The mosquito repellent product according to claim 6, characterized in that, The product is a mosquito repellent liquid, mosquito repellent patch, mosquito repellent cream, or mosquito repellent gel.

8. A mosquito repellent liquid, characterized in that, It contains the following components by weight percentage: 1%–10% caryophyllene oxide, 1%–12% eucalyptol, 1%–10% linalool, 1%–10% α-terpineol, 1%–10% δ-juniperene, and the balance being solvent.

9. The mosquito repellent liquid according to claim 8, characterized in that, It contains the following components by weight percentage: 3%–10% caryophyllene oxide, 1%–12% eucalyptol, 3%–10% linalool, 1%–10% α-terpineol, 1%–10% δ-juniperene, and the balance being solvent.

10. The mosquito repellent liquid according to claim 8 or 9, characterized in that, The solvent is ethanol.

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