Oral composition with gastric mucosal lesion auxiliary protection function and application thereof

Abstract

The invention discloses an oral composition with a gastric mucosal lesion auxiliary protection function and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-10 parts of radix scutellariae, 3-10 parts of fermented soybean, 3-10 parts of fructus gardeniae, 3-10 parts of fructus aurantii immaturus, 3-10 parts of cortex magnoliae officinalis, 1-3 parts of radix glycyrrhizae preparata, 1-3 parts of rhizoma zingiberis, 1-3 parts of fructus jujubae, 3-10 parts of poria cocos, 2-10 parts of pericarpium citri reticulatae, 3-10 parts of herba patriniae, 3-10 parts of caulis bambusae in taeniam, 3-10 parts of flos inulae, 3-10 parts of ruddle, 1-5 parts of radix ginseng, 3-10 parts of rhizoma atractylodis macrocephalae, 3-10 parts of radix et rhizoma rhei preparata, 1-3 parts of radix notoginseng, 1-3 parts of According to the present invention, the scientific compatibility of the natural traditional Chinese medicine composition is adopted, the core pathological link of the gastric mucosa lesion is precisely focused, the multi-target synergistic effect of heat clearing, qi regulating, spleen strengthening, tissue regeneration promoting and the like is combined with the standardized extraction process to achieve the efficient and stable production, the composition is suitable for various dosage forms and applications, and the mild and strong-targeting conditioning scheme is provided for the protection and repair of the gastric mucosa.

Description

Technical Field

[0001] This invention relates to the field of health product technology, specifically to an oral composition with auxiliary protective function against gastric mucosal damage and its application. Background Technology

[0002] With the accelerated pace of modern life, changes in dietary habits, and increased work pressure, the incidence of gastric mucosal damage-related diseases has been rising year by year, becoming a common problem affecting public health and quality of life. As the innermost layer of the stomach wall, the gastric mucosa has important physiological functions such as secreting gastric acid, pepsin, and mucus. It is also the first line of defense against harmful factors such as gastric acid, drugs, alcohol, and pathogens. When the gastric mucosal defense mechanism and attacking factors are out of balance, it is very easy to cause mucosal inflammation, erosion, ulcers, and even bleeding and perforation, which can induce diseases such as chronic gastritis, gastric ulcers, and reflux esophagitis. Long-term repeated attacks may also increase the risk of gastric cancer.

[0003] Currently, the main approaches to the protection and repair of gastric mucosal damage fall into two categories: chemical drugs and traditional Chinese medicine (TCM) compositions. However, both have certain drawbacks. While chemical drugs can quickly relieve some symptoms, long-term use can easily lead to side effects such as dry mouth, constipation, and intestinal flora imbalance. Moreover, they are difficult to fundamentally repair the damaged gastric mucosal barrier, resulting in a high recurrence rate. Although TCM compositions have the advantages of being mild and having few side effects, existing formulas often suffer from weak formulation targeting and a single mechanism of action. They may focus only on relieving inflammation or solely on mucosal repair, failing to achieve a synergistic effect of "prevention-protection-repair." Furthermore, some formulas suffer from complex ingredients, unstable efficacy, and low utilization rates of effective components due to unreasonable preparation processes, making it difficult to meet the diversified and efficient needs for auxiliary protection of gastric mucosal damage in clinical practice and daily health care.

[0004] Therefore, an oral composition with auxiliary protective function against gastric mucosal injury and its application are proposed to solve the problems mentioned above. Summary of the Invention

[0005] The purpose of this invention is to provide an oral composition with auxiliary protective function against gastric mucosal injury and its application, in order to solve the problems mentioned in the background art, such as large side effects, easy recurrence, single action and unstable effect of current chemical drugs and traditional Chinese medicine compositions in gastric mucosal protection and repair, which make it difficult to meet the comprehensive needs of synergistic protection and efficient repair.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an oral composition with auxiliary protective function against gastric mucosal damage, made from the following raw materials in parts by weight: 3-10 parts of Scutellaria baicalensis, 3-10 parts of fermented soybean, 3-10 parts of Gardenia jasminoides, 3-10 parts of Citrus aurantium, 3-10 parts of Magnolia officinalis, 1-3 parts of prepared licorice root, 1-3 parts of dried ginger, 1-3 parts of jujube, 3-10 parts of Poria cocos, 2-10 parts of dried tangerine peel, 3-10 parts of Patrinia scabiosaefolia, 3-10 parts of bamboo shavings, 3-10 parts of Inula japonica, 3-10 parts of hematite, 1-5 parts of ginseng, 3-10 parts of Atractylodes macrocephala, 3-10 parts of prepared rhubarb, 1-3 parts of Panax notoginseng, 1-3 parts of Bletilla striata, and 1-3 parts of Pu-erh tea.

[0007] Preferably, it is made from the following raw materials in parts by weight: 5-8 parts Scutellaria baicalensis, 5-8 parts fermented soybean, 5-8 parts Gardenia jasminoides, 5-8 parts Citrus aurantium, 5-8 parts Magnolia officinalis, 1-2 parts prepared licorice root, 1-2 parts dried ginger, 1-2 parts jujube, 5-8 parts Poria cocos, 3-6 parts dried tangerine peel, 5-8 parts Patrinia scabiosaefolia, 5-8 parts bamboo shavings, 5-8 parts Inula japonica, 5-8 parts hematite, 2-4 parts ginseng, 5-8 parts Atractylodes macrocephala, 5-8 parts prepared rhubarb, 1-2 parts Panax notoginseng, 1-2 parts Bletilla striata, and 1-2 parts Pu-erh tea.

[0008] Preferably, it is made from the following raw materials in parts by weight: 6 parts Scutellaria baicalensis, 6 parts fermented soybean, 6 parts Gardenia jasminoides, 6 parts Citrus aurantium, 6 parts Magnolia officinalis, 2 parts prepared licorice root, 2 parts dried ginger, 2 parts jujube, 6 parts Poria cocos, 6 parts dried tangerine peel, 6 parts Patrinia scabiosaefolia, 6 parts bamboo shavings, 6 parts Inula japonica, 6 parts hematite, 3 parts ginseng, 6 parts Atractylodes macrocephala, 6 parts prepared rhubarb, 2 parts Panax notoginseng, 2 parts Bletilla striata, and 2 parts Pu-erh tea.

[0009] Preferably, the raw material is a Chinese medicinal herb, a prepared slice of Chinese medicinal herb, or a Chinese medicinal herb extract.

[0010] The present invention also provides a method for taking the oral composition, comprising the following steps:

[0011] (a) Weigh each raw material according to the stated weight proportions and mix them;

[0012] (b) Extract the mixture from step (a) with a solvent and collect the extract;

[0013] (c) The extract obtained in step (b) is concentrated and / or dried to obtain an extract of the oral composition.

[0014] Preferably, in step (b), the solvent is water or an aqueous solution of ethanol with a volume fraction of 30%-70%.

[0015] Preferably, when the solvent is water, the extraction method is decoction, which is carried out 1-3 times, with the amount of water added each time being 6-15 times the total weight of the raw materials, and each decoction lasting 30-120 minutes; preferably, the raw materials are soaked for 15-60 minutes before decoction.

[0016] Preferably, when the solvent is an aqueous ethanol solution, the extraction method is reflux extraction, with 1-3 extractions, each extraction lasting 30-120 minutes.

[0017] Preferably, in step (c), the concentration is to concentrate the extract to a paste with a relative density of 1.10-1.40; and / or, the drying is to spray dry, vacuum dry, or freeze dry.

[0018] The present invention also provides the use of the oral composition described herein in the preparation of products for assisting in the protection of the gastric mucosa and preventing or reducing gastric mucosal damage.

[0019] Preferably, the product is a pharmaceutical, health food, or ordinary food.

[0020] Preferably, the dosage form of the medicine or health food is oral liquid, granules, tablets, capsules, powders or pills.

[0021] The present invention also provides a product for assisting in the protection of the gastric mucosa, comprising the oral composition according to any one of claims 1-4 and food- or pharmaceutically acceptable excipients.

[0022] Preferably, the product is a pharmaceutical or health food, and the dosage form is an oral liquid, granules, tablets, capsules, powders, or pills.

[0023] Compared with existing technologies, the beneficial effects of this invention are as follows: This oral composition with auxiliary protective function against gastric mucosal injury and its application, through a scientifically formulated natural Chinese herbal medicine composition, precisely targets the core pathological links of gastric mucosal injury, achieving synergistic effects from multiple targets such as clearing heat, regulating qi, strengthening the spleen, and promoting tissue regeneration. Combined with standardized extraction processes, it achieves efficient and stable production, is suitable for various dosage forms and uses, and provides a gentle yet highly targeted conditioning solution for the protection and repair of the gastric mucosa. The specific details are as follows:

[0024] Firstly, the Scutellaria baicalensis, Gardenia jasminoides, and Patrinia scabiosaefolia in the composition clear heat, dry dampness, detoxify, and reduce inflammation, inhibiting gastric mucosal inflammation at its source and preventing damage. Citrus aurantium, Magnolia officinalis, and Citrus reticulata regulate qi, harmonize the stomach, relieve bloating and pain, improving gastrointestinal motility, reducing gastric mucosal irritation, and actively protecting the gastric mucosa. Ginseng, Atractylodes macrocephala, and Glycyrrhiza uralensis invigorate qi and strengthen the spleen, while Panax notoginseng and Bletilla striata promote blood circulation, remove blood stasis, reduce swelling, and promote tissue regeneration, promoting the proliferation and repair of damaged gastric mucosal epithelial cells and rebuilding the gastric mucosal barrier. Pu-erh tea aids digestion, relieves greasiness, and harmonizes the other herbs, further enhancing the overall efficacy of the formula. The synergistic effect of these ingredients overcomes the drawbacks of complex traditional Chinese medicine components, focusing specifically on the core pathological aspects of gastric mucosal damage. All ingredients are natural Chinese medicinal materials, mild with no obvious side effects, making them more suitable for long-term treatment than chemical drugs, and offering more stable and targeted efficacy compared to traditional Chinese medicine compositions.

[0025] Secondly, by clearly defining the solvent type and ratio, extraction method, extraction parameters, and concentration and drying conditions, the active ingredients in each raw material can be preserved to the maximum extent, improving the purity and efficacy stability of the extract. This also simplifies the production process and facilitates large-scale industrial production. Furthermore, the composition of this invention can be widely used in pharmaceuticals, health foods, or ordinary foods, and can be prepared in various dosage forms such as oral liquids, granules, and tablets, meeting the needs of different user groups and significantly expanding its application scenarios. This effectively meets the diversified and efficient needs for auxiliary protection against gastric mucosal damage in clinical treatment and daily health care. Detailed Implementation

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0027] Example 1

[0028] Ingredient ratio (by weight): Scutellaria baicalensis 6 parts, fermented soybean 6 parts, gardenia 6 parts, immature bitter orange 6 parts, magnolia bark 6 parts, prepared licorice root 2 parts, dried ginger 2 parts, jujube 2 parts, Poria cocos 6 parts, dried tangerine peel 6 parts, Patrinia scabiosaefolia 6 parts, bamboo shavings 6 parts, Inula japonica 6 parts, hematite 6 parts, ginseng 3 parts, Atractylodes macrocephala 6 parts, prepared rhubarb 6 parts, Panax notoginseng 2 parts, Bletilla striata 2 parts, Pu-erh tea 2 parts.

[0029] According to the above proportions, accurately weigh the following ingredients: 60g Scutellaria baicalensis, 60g fermented soybean, 60g Gardenia jasminoides, 60g Citrus aurantium, 60g Magnolia officinalis, 20g prepared licorice root, 20g dried ginger, 20g jujube, 60g Poria cocos, 60g dried tangerine peel, 60g Patrinia scabiosaefolia, 60g bamboo shavings, 60g Inula japonica, 60g hematite, 30g ginseng, 60g Atractylodes macrocephala, 60g prepared rhubarb, 20g Panax notoginseng, 20g Bletilla striata, and 20g Pu-erh tea, for a total weight of 840g.

[0030] Preparation method

[0031] (1) Raw material pretreatment: Wrap Inula japonica in gauze, grind hematite into fine powder (pass through 80 mesh sieve), wash and dry the other Chinese medicinal materials and grind them into coarse powder (pass through 20 mesh sieve) for later use;

[0032] (2) Mixing: Place all the pretreated raw materials in a mixer and mix for 30 minutes to obtain mixed raw materials;

[0033] (3) Water extraction: Place the mixed raw materials in a multi-functional extraction tank, add 10 times the total weight of the raw materials (8400mL) of purified water, soak for 30 minutes, heat and decoct, keep at a gentle boil for 60 minutes, filter and collect the first extract; add 8 times the total weight of the raw materials (6720mL) of purified water to the residue again, continue to decoct for 45 minutes, filter and collect the second extract; combine the two extracts to obtain a total extract of about 12000mL;

[0034] (4) Concentration: The total extract is placed in a vacuum concentration tank and concentrated under vacuum conditions of 0.06-0.08 MPa and 60-70℃ until the extract has a relative density of 1.25 (measured at 60℃) and a weight of about 420g.

[0035] (5) Drying: Place the extract in a spray dryer, set the inlet air temperature to 180°C and the outlet air temperature to 80°C, and spray dry to obtain about 140g of dried powder;

[0036] (6) Granulation: Add an appropriate amount of dextrin (30% of the powder weight, i.e., 42g) and steviol glycoside (0.5% of the powder weight, i.e., 0.7g) to the dry powder, mix evenly, add an appropriate amount of purified water to make soft material, granulate through a 16-mesh sieve, place the wet granules in an oven, dry at 60°C until the moisture content is ≤5%, and then granulate through a 14-mesh sieve to obtain oral composition granules.

[0037] Example 2

[0038] Ingredient ratio (by weight): Scutellaria baicalensis 7 parts, fermented soybean 7 parts, gardenia 7 parts, immature bitter orange 7 parts, magnolia bark 7 parts, prepared licorice root 1.5 parts, dried ginger 1.5 parts, jujube 1.5 parts, Poria cocos 7 parts, dried tangerine peel 5 parts, Patrinia scabiosaefolia 7 parts, bamboo shavings 7 parts, Inula japonica 7 parts, hematite 7 parts, ginseng 3 parts, Atractylodes macrocephala 7 parts, prepared rhubarb 7 parts, Panax notoginseng 1.5 parts, Bletilla striata 1.5 parts, Pu-erh tea 1.5 parts.

[0039] According to the above proportions, accurately weigh the following ingredients: 70g Scutellaria baicalensis, 70g fermented soybean, 70g Gardenia jasminoides, 70g Citrus aurantium, 70g Magnolia officinalis, 15g prepared licorice root, 15g dried ginger, 15g jujube, 70g Poria cocos, 50g dried tangerine peel, 70g Patrinia scabiosaefolia, 70g bamboo shavings, 70g Inula japonica, 70g hematite, 30g ginseng, 70g Atractylodes macrocephala, 70g prepared rhubarb, 15g Panax notoginseng, 15g Bletilla striata, and 15g Pu-erh tea, for a total weight of 880g.

[0040] Preparation method

[0041] (1) Raw material pretreatment: Same as step (1) in Example 1;

[0042] (2) Mixing: Same as step (2) in Example 1;

[0043] (3) Ethanol extraction: Place the mixed raw materials in a reflux extraction device, add 7040 mL of 50% ethanol aqueous solution (8 times the total weight of the raw materials), heat and reflux for 60 minutes, filter, and collect the first extract; add 5280 mL of 50% ethanol aqueous solution (6 times the total weight of the raw materials) to the residue again, continue to reflux for 45 minutes, filter, and collect the second extract; combine the two extracts to obtain a total extract of about 10000 mL;

[0044] (4) Concentration: The total extract is placed in a vacuum concentration tank and concentrated under vacuum conditions of 0.06-0.08 MPa and 50-60℃. Ethanol is recovered and the extract is concentrated until there is no alcohol odor. The extract is further concentrated to a relative density of 1.30 (measured at 60℃). The weight of the extract is about 440g.

[0045] (5) Drying: The extract was placed in a vacuum drying oven and vacuum dried for 12 hours at a vacuum degree of 0.08 MPa and a temperature of 55°C to obtain a dried block. After crushing, it was passed through an 80-mesh sieve to obtain about 150g of dried powder.

[0046] (6) Capsule filling: Place the dry powder in a capsule filling machine and fill it into No. 0 empty capsules. Each capsule contains 0.3g, thus obtaining the oral composition capsule.

[0047] Example 3

[0048] Ingredient ratio (by weight): Scutellaria baicalensis 3 parts, fermented soybean 3 parts, gardenia 3 parts, immature bitter orange 3 parts, magnolia bark 3 parts, prepared licorice root 1 part, dried ginger 1 part, jujube 1 part, Poria cocos 3 parts, dried tangerine peel 2 parts, Patrinia scabiosaefolia 3 parts, bamboo shavings 3 parts, Inula japonica 3 parts, hematite 3 parts, ginseng 1 part, Atractylodes macrocephala 3 parts, prepared rhubarb 3 parts, Panax notoginseng 1 part, Bletilla striata 1 part, Pu-erh tea 1 part.

[0049] According to the above proportions, accurately weigh the following ingredients: 30g Scutellaria baicalensis, 30g fermented soybean, 30g Gardenia jasminoides, 30g Citrus aurantium, 30g Magnolia officinalis, 10g prepared licorice root, 10g dried ginger, 10g jujube, 30g Poria cocos, 20g dried tangerine peel, 30g Patrinia scabiosaefolia, 30g bamboo shavings, 30g Inula japonica, 30g hematite, 10g ginseng, 30g Atractylodes macrocephala, 30g prepared rhubarb, 10g Panax notoginseng, 10g Bletilla striata, and 10g Pu-erh tea, for a total weight of 390g.

[0050] Preparation method

[0051] (1) Raw material pretreatment: Same as step (1) in Example 1;

[0052] (2) Mixing: Same as step (2) in Example 1;

[0053] (3) Water extraction: Place the mixed raw materials in a multi-functional extraction tank, add 12 times the total weight of the raw materials (4680mL) of purified water, soak for 15 minutes, heat and decoct, keep at a gentle boil for 120 minutes, filter and collect the extract; add 6 times the total weight of the raw materials (2340mL) of purified water to the residue, decoct for 30 minutes, filter and collect the second extract; combine the two extracts to obtain a total extract of about 5500mL;

[0054] (4) Concentration: The total extract was concentrated under reduced pressure to a relative density of 1.10 (measured at 60°C), and the weight of the extract was approximately 195g.

[0055] (5) Preparation: Add purified water to the extract to 1000mL, stir well, add 0.1% sodium benzoate (1g) as a preservative, stir to dissolve, and adjust the pH value to 4.5-5.5 with citric acid;

[0056] (6) Clarification and filling: Filter the prepared solution through a 0.45μm microporous membrane, clarify it, and fill it into 10mL oral liquid bottles. Fill each bottle with 10mL and sterilize (121℃, 15 minutes) to obtain the oral composition oral liquid.

[0057] Verification experiment on the effect of oral composition in assisting the protection of gastric mucosa

[0058] Experimental objective: To verify the auxiliary protective effect of the oral composition of the present invention on anhydrous ethanol-induced gastric mucosal damage in rats.

[0059] Experimental grouping and drug administration

[0060] Sixty SPF-grade SD rats weighing 200-220g were selected, half male and half female, and randomly divided into 6 groups of 10 rats each: blank control group, model control group, low-dose granule group of Example 1 (hereinafter referred to as low-dose group), medium-dose granule group of Example 1 (hereinafter referred to as medium-dose group), high-dose granule group of Example 1 (hereinafter referred to as high-dose group), and positive control group (sucralfate suspension group).

[0061] Dosage and administration method: The low-dose group was given the granules prepared in Example 1 by gavage at a dose of 2 g / kg·d of crude drug; the medium-dose group was given by gavage at a dose of 4 g / kg·d of crude drug; the high-dose group was given by gavage at a dose of 8 g / kg·d of crude drug; the positive control group was given sucralfate suspension (10% concentration) by gavage at a dose of 1 g / kg·d; the blank control group and the model control group were given an equal volume of physiological saline by gavage. All groups were administered the drug by gavage for 7 consecutive days, once a day, with a gavage volume of 10 mL / kg.

[0062] Modeling and Testing

[0063] Two hours after the last administration, except for the blank control group, all rats in the other groups were administered 1 mL of anhydrous ethanol by gavage to establish a gastric mucosal injury model. One hour after modeling, all rats were fasted but allowed to drink water, euthanized by cervical dislocation, and their stomachs were quickly dissected, rinsed with physiological saline, cut along the greater curvature of the stomach, laid flat on filter paper, and the extent of gastric mucosal injury was observed.

[0064] The Guth method was used to calculate the gastric mucosal injury index: no injury was 0 points; injury width < 1 mm, length < 1 mm was 1 point; injury width < 1 mm, length 1-5 mm was 2 points; injury width < 1 mm, length > 5 mm was 3 points; injury width > 1 mm, length 1-5 mm was 4 points; injury width > 1 mm, length > 5 mm was 5 points; for multiple injuries, the total score was accumulated. Simultaneously, the gastric mucosal ulcer area (mm²) was measured, and the gastric mucosal protection rate was calculated: Protection rate (%) = (mean injury index of the model control group - mean injury index of the treatment group) / mean injury index of the model control group × 100%.

[0065] In addition, appropriate amounts of gastric mucosal tissue from each group of rats were taken, and the contents of malondialdehyde (MDA), superoxide dismutase (SOD) activity, and glutathione peroxidase (GSH-Px) activity in the gastric mucosal tissue were detected according to the instructions of the kit.

[0066] Experimental results

[0067] Results of gastric mucosal injury index and protection rate: The experimental results are shown in Table 1. As shown in Table 1, the gastric mucosa of rats in the model control group showed obvious congestion, edema, erosion and ulceration, with a mean injury index of 18.62±2.35. Compared with the model control group, the gastric mucosal injury index of the low, medium and high dose groups and the positive control group were significantly reduced (P<0.01). Moreover, with the increase of the oral composition of the present invention, the injury index gradually decreased and the protection rate gradually increased. The protection rate of the high dose group reached 78.3%, which is close to the 80.5% of the positive control group. This indicates that the oral composition of the present invention has a significant auxiliary protective effect against anhydrous ethanol-induced gastric mucosal injury, and this effect is dose-dependent.

[0068] Table 1

[0069]

[0070] Biochemical indicators of gastric mucosa tissue: The experimental results are shown in Table 2. Table 2 shows that the MDA content in the gastric mucosa tissue of the model control group was significantly increased, while the activities of SOD and GSH-Px were significantly decreased (P < 0.01). Compared with the model control group, the MDA content in the low-, medium-, and high-dose groups and the positive control group was significantly decreased (P < 0.01), while the activities of SOD and GSH-Px were significantly increased (P < 0.01). Furthermore, the improvement in biochemical indicators in the high-dose group was close to that in the positive control group. This indicates that the oral composition of the present invention may play an auxiliary protective role in the gastric mucosa by improving the antioxidant capacity of the gastric mucosa tissue and reducing lipid peroxidation damage.

[0071] Table 2

[0072]

[0073] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An oral composition with auxiliary protective function against gastric mucosal injury, characterized in that, Made from the following ingredients in parts by weight: Scutellaria baicalensis 3-10 parts, fermented soybean 3-10 parts, Gardenia jasminoides 3-10 parts, Citrus aurantium 3-10 parts, Magnolia officinalis 3-10 parts, prepared licorice root 1-3 parts, dried ginger 1-3 parts, jujube 1-3 parts, Poria cocos 3-10 parts, dried tangerine peel 2-10 parts, Patrinia scabiosaefolia 3-10 parts, bamboo shavings 3-10 parts, Inula japonica 3-10 parts, hematite 3-10 parts, ginseng 1-5 parts, Atractylodes macrocephala 3-10 parts, prepared rhubarb 3-10 parts, Panax notoginseng 1-3 parts, Bletilla striata 1-3 parts, Pu-erh tea 1-3 parts.

2. The oral composition according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: Scutellaria baicalensis 5-8 parts, fermented soybean 5-8 parts, Gardenia jasminoides 5-8 parts, Citrus aurantium 5-8 parts, Magnolia officinalis 5-8 parts, prepared licorice root 1-2 parts, dried ginger 1-2 parts, jujube 1-2 parts, Poria cocos 5-8 parts, dried tangerine peel 3-6 parts, Patrinia scabiosaefolia 5-8 parts, bamboo shavings 5-8 parts, Inula japonica 5-8 parts, hematite 5-8 parts, ginseng 2-4 parts, Atractylodes macrocephala 5-8 parts, prepared rhubarb 5-8 parts, Panax notoginseng 1-2 parts, Bletilla striata 1-2 parts, and Pu-erh tea 1-2 parts.

3. The oral composition according to claim 2, characterized in that, It is made from the following ingredients in parts by weight: 6 parts Scutellaria baicalensis, 6 parts fermented soybean, 6 parts Gardenia jasminoides, 6 parts Citrus aurantium, 6 parts Magnolia officinalis, 2 parts prepared licorice root, 2 parts dried ginger, 2 parts jujube, 6 parts Poria cocos, 6 parts dried tangerine peel, 6 parts Patrinia scabiosaefolia, 6 parts bamboo shavings, 6 parts Inula japonica, 6 parts hematite, 3 parts ginseng, 6 parts Atractylodes macrocephala, 6 parts prepared rhubarb, 2 parts Panax notoginseng, 2 parts Bletilla striata, and 2 parts Pu-erh tea.

4. The oral composition according to any one of claims 1-3, characterized in that, The raw materials are Chinese medicinal herbs, prepared slices of Chinese medicinal herbs, or extracts of Chinese medicinal herbs.

5. A method for preparing the oral composition according to any one of claims 1-3, characterized in that, Includes the following steps: (a) Weigh each raw material according to the stated weight proportions and mix them; (b) Extract the mixture from step (a) with a solvent and collect the extract; (c) The extract obtained in step (b) is concentrated and / or dried to obtain an extract of the oral composition.

6. The method according to claim 5, characterized in that, In step (b), the solvent is water or an aqueous solution of ethanol with a volume fraction of 30%-70%.

7. The method according to claim 6, characterized in that, When the solvent is water, the extraction method is decoction, which is carried out 1-3 times. Each time, the amount of water added is 6-15 times the total weight of the raw materials, and each decoction lasts for 30-120 minutes. Preferably, the raw materials are soaked for 15-60 minutes before decoction.

8. The method according to claim 6, characterized in that, When the solvent is an aqueous ethanol solution, the extraction method is heating and reflux extraction, 1-3 times, each extraction lasting 30-120 minutes.

9. The method according to any one of claims 5-8, characterized in that, In step (c), the concentration is to concentrate the extract to a paste with a relative density of 1.10-1.40; and / or, the drying is to spray dry, vacuum dry or freeze dry.

10. The use of the oral composition according to any one of claims 1-4 in the preparation of products for assisting in the protection of the gastric mucosa and preventing or reducing gastric mucosal damage.

11. The application according to claim 10, characterized in that, The product is a pharmaceutical, health food, or ordinary food.

12. The application according to claim 11, characterized in that, The dosage form of the medicine or health food is oral liquid, granules, tablets, capsules, powders or pills.

13. A product for assisting in the protection of the gastric mucosa, characterized in that, It comprises the oral composition according to any one of claims 1-4 and food- or pharmaceutically acceptable excipients.

14. The product according to claim 13, characterized in that, The product is a pharmaceutical or health food, and its dosage form is oral liquid, granules, tablets, capsules, powders, or pills.

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