System for extracting tissue samples from fluid streams generated during medical / surgical procedures

Abstract

A cartridge (2600) for use with a medical waste collection system (30). The cartridge includes a housing (2602, 2612) shaped to be removably attached to a receptacle (1699) integral with the housing. A sleeve (2640) is attached to the cartridge to be positioned in front of the housing. The sleeve is formed with a void space. A connector (2664) leading to the suction line for collection is attached to the cannula. A screen (2714) is removably mounted within the casing void space. When it is desired to capture tissue that may be contained in the fluid flow from the suction line, the screen is mounted within the cannula void space.

Description

[0001] This application is a divisional application of patent application No. 201811098553.X, filed on December 13, 2012, entitled "System for Extracting Tissue Samples from Fluid Flows Generated During Medical / Surgical Procedures," which in turn is a divisional application of patent application No. 201280069839.X, entitled "System for Extracting Tissue Samples from Fluid Flows Generated During Medical / Surgical Procedures." Technical Field

[0002] This invention generally relates to systems and methods for collecting waste and extracting tissue samples during surgical procedures. More specifically, this invention relates to systems and methods for extracting tissue samples from the gastrointestinal tract during surgical procedures such as colonoscopy. Background Technology

[0003] The byproducts of some medical and surgical procedures include the generation of liquid, semi-solid, and solid waste. This waste includes bodily fluids such as blood and irrigation fluids introduced into the surgical site. Solid and semi-solid waste generated during surgery includes tissue particles and small fragments of surgical material that may remain at the site. Ideally, this waste should be collected as it is generated so that it does not obstruct vision, clog the surgical site, or become a biohazard in the operating room or other areas where surgery is being performed.

[0004] Many systems can be used by surgical personnel to collect waste as it is generated. Generally, these units include a suction source, tubing extending from the suction source, and a closed unit between the tubing and the suction source. When the system is actuated, waste is aspirated through the distal end of the tubing. The suction force draws the waste through the tubing, causing it to flow into the closed unit and be stored therein. One such system is the NEPTUNE Surgical Waste Collection System, assigned to the applicant. This particular system includes a movable unit comprising a suction pump and two tanks. Tubing is connected to each tank via a removable manifold. Because this unit is movable, it can be positioned relatively close to the patient performing the procedure. This reduces the length of the suction tubing present around the surgical personnel, which always interferes with the operating room. This system also features reduced exposure of surgical and support personnel to the material collected by the system. Several features of this system are described in U.S. Patent No. 7,621,898, issued November 24, 2009, the contents of which are incorporated herein by reference.

[0005] The system is characterized by an intake manifold. This manifold includes a filter element that traps large particles of solid matter. This is desirable because these solids can clog components located near the system's proximal end. Furthermore, the manifold is formed of a material that allows it to be provided as a single-use item. After use of the system, the manifold, with its narrow conduit or internal filter, does not require laborious sterilization. Instead, personnel handling the used manifold only need to come into contact with the outer surface of the component. This process also minimizes the extent to which these personnel may come into contact with waste materials. A more detailed description of this type of manifold is given in U.S. Patent No. 7,615,037, assigned to the applicant and published November 10, 2009, the contents of which are incorporated herein by reference.

[0006] In some surgical procedures, such as colonoscopy, it is desirable to collect one or more tissue samples from the patient during the procedure. These samples are typically sent to a laboratory for automated analysis or analyzed manually by a specialist, such as a pathologist. To collect the tissue sample, the tubing connecting the medical instrument used to apply suction to the patient to the closed unit is manually disconnected. A separate device is then placed in series with this tubing and positioned upstream of the closed unit. The tissue sample is captured in this device. This device is then removed, and the tubing from the suction applicator is reconnected directly to the closed unit. Repeatedly connecting and disconnecting the tubing during the collection of multiple samples increases the time required to complete the procedure. After disconnecting the tubing, small amounts of residual liquid and semi-solid waste adhering to the tubing may be released into the surrounding environment, potentially contaminating the floor and other surfaces within the surgical equipment. Summary of the Invention

[0007] This invention relates to a novel and useful system and method for extracting tissue samples during medical and surgical procedures such as colonoscopy. The system of the invention includes a movable unit, an irrigation fluid source, and a container for collecting waste, all connected thereto. A removable cartridge is attached to the movable unit. In many forms of the invention, the cartridge is housed within a reservoir, which is a structural component of the waste collection unit. The cartridge has a connector for receiving a suction line extending from a suction applicator. The cartridge also has an outlet leading into the waste collection unit container. A tissue trap is removably mounted to the cartridge. The tissue trap is selectively arranged in series with the fluid flow aspirated through the cartridge by suction force. The trap includes a filter for capturing tissue contained in the fluid flow aspirated into the movable unit.

[0008] In some forms of the invention, the tissue trap is selectively attached to the cassette. In these forms of the invention, when the tissue trap is not attached to the cassette, fluid flow proceeds through a first set of conduits within the cassette into the container. When it is desired to remove the tissue specimen from the fluid flow, the tissue trap is temporarily attached to the cassette. This allows fluid flow to pass through the trap. Thus, as the remaining material contained in the waste stream flows into the cassette, the tissue is retained in the trap.

[0009] In other forms of the invention, the tissue trap, although removably attached to the cartridge, can be attached to the cartridge even when tissue collection is not required. In these forms of the invention, one or more valves are used to regulate the path of the waste fluid flow through the cartridge. If tissue collection is not required, the valve / valve is placed in a bypass mode. When the valve is in bypass mode, fluid flow does not pass through the trap. When tissue collection is desired, the valve / valve is set to a tissue collection mode. When the valve / valve is in this mode, fluid flow passes through the tissue trap before being discharged into the waste collection tank. Tissue is blocked by a filter integrated with the trap and does not flow downstream into the waste collection tank.

[0010] In each form of the invention, once tissue has been captured in one capture device, another capture device can be attached to the cassette. This makes it possible to capture multiple specimens during a single surgical procedure, while only a single cassette is attached to the waste collection unit. Because only a single cassette is configured, it is not necessary to frequently disconnect the aspiration tube from different cassettes and reconnect the aspiration tube to different cassettes during the procedure. Attached Figure Description

[0011] The present invention has been described using the features of the claims. The above and other features and advantages of the invention will be understood from the following detailed description given with reference to the accompanying drawings, in which: Figure 1A This is a side view of the medical / surgical waste collection system of the present invention; Figure 1B It is used for control Figure 1A A schematic diagram of the control system for the operation of a medical / surgical waste collection system; Figure 1C This is a cross-sectional view of a colonoscopy. Figure 2 This is a cross-sectional view of a manifold assembly installed within a waste collection system; Figure 3 This is a right front perspective view of a manifold assembly according to one embodiment; Figure 4 This is a front left perspective view of the manifold assembly; Figure 5 This is an exploded view of the front of the manifold assembly; Figure 6 This is an exploded view of the rear of the manifold assembly; Figure 7 This is an exploded top view of the box; Figure 8 This is an exploded view of the box from below; Figure 9A This is a rear view of the upper housing with the flushing connector in the open position; Figure 9B This is a top view of the upper housing with the flushing connector in the open position; Figure 9C This is a front view of the upper housing with the flushing connector in the open position; Figure 9D This is a right view of the upper housing with the flushing connector in the open position; Figure 9E This is a bottom view of the upper housing with the flushing connector in the open position; Figure 9F It is a bottom perspective view of the upper housing with the flushing connector in the open position; Figure 9G This is a top perspective view of the upper housing with the flushing connector in the open position; Figure 10A This is a rear view of the upper housing with the flushing connector in the closed position; Figure 10B This is a top view of the upper housing with the flushing connector in the closed position; Figure 10C This is a front view of the upper housing with the flushing connector in the closed position; Figure 10D This is a right-side view of the upper housing with the flushing connector in the closed position; Figure 10E This is a bottom view of the upper housing with the flushing connector in the closed position; Figure 10F This is a bottom perspective view of the upper housing with the flushing connector in the closed position; Figure 10G This is a top perspective view of the upper housing with the flushing connector in the closed position; Figure 11A This is a top view of a tissue trap with a screen in the closed position; Figure 11B This is a rear view of a tissue trap with a screen in the closed position; Figure 11C The left image shows a tissue trap with a screen in the closed position. Figure 11DThis is a rear perspective view of a tissue trap with a screen in the closed position; Figure 11E It is a front perspective view of a tissue trap with a screen in the closed position; Figure 12A It is a top view of a tissue trap with a screen in the open position; Figure 12B This is a rear view of a tissue trap with a screen in the open position; Figure 12C The left image shows a tissue trap with a screen in the open position. Figure 12D This is a rear perspective view of a tissue trap with a screen in the open position; Figure 12E It is a front perspective view of a tissue trap with a screen in the open position; Figure 13 It is a three-dimensional view of the specimen container and tissue trap; Figure 14 This is a three-dimensional view of the tissue trap contained within the specimen container; Figure 15A This is a left front perspective view of another embodiment of the manifold assembly; Figure 15B This is a cross-sectional view of the manifold assembly shown in Figure 15, which is installed in a waste collection system. Figure 16 This is a front left exploded view of the manifold assembly in Figure 15; Figure 17 This is a cross-sectional view of the manifold assembly in Figure 15; Figure 18A This is an exploded perspective view of the box in Figure 15; Figure 18B This is a 3D view of the lower shell; Figure 18C This is a top view of the lower shell; Figure 18D This is a bottom view of the lower casing; Figure 18E This is a front view of the lower shell; Figure 18F This is a right-side view of the upper casing; Figure 19 It shows Figure 18A A magnified, 3D exploded view of the details; Figure 20A It is a three-dimensional view of the valve component; Figure 20B This is a bottom view of the valve component; Figure 20C This is a side view of the valve component; Figure 20D This is a top view of the valve component; Figure 21A It is a three-dimensional diagram of the tissue trap; Figure 21B This is a top view of the tissue capture device; Figure 21C This is a front view of the tissue capture device; Figure 21D This is a side view of the tissue trap; Figure 21E This is the rear view of the tissue capture device; Figure 21F This is a bottom view of the tissue capture device; Figure 22A This is a three-dimensional view of the tissue trap contained within the specimen container; Figure 22B This is a top view of the tissue trap contained within the specimen container; Figure 22C This is a front view of the tissue trap contained within the specimen container; Figure 22D It is the edge of the tissue trap contained within the specimen container. Figure 22C The sectional view taken by section line 22D-22D in the diagram; Figure 23 This is a front left exploded view of another embodiment of the manifold assembly; Figure 24A yes Figure 23 A right front perspective view of the manifold assembly; Figure 24B This is a cross-sectional view of the actuator and clamping valve; Figure 25 yes Figure 23 A front view of the manifold component; Figure 26 This is a top-down exploded 3D view of the box; Figure 27 This is a bottom-view, exploded 3D diagram of the box; Figure 28A This is a top view of the lower casing; Figure 28B This is a right-side view of the lower casing. Figure 28C This is a bottom view of the lower casing; Figure 29A This is a top view of the rubber sheet; Figure 29B This is a right-side view of the rubber sheet; Figure 29C This is a bottom view of the rubber sheet; Figure 30A This is a top view of the upper casing; Figure 30B This is a right-side view of the upper casing; Figure 30C This is a bottom view of the upper casing; Figure 31 This is an exploded top view of the tissue trap and specimen container; Figure 32 It is an exploded bottom view of the tissue trap and specimen container; Figure 33 It is an exploded top view of the water bottle; and Figure 34 This is an exploded bottom view of the water bottle.

[0012] Figure 35 This is a perspective view of another embodiment of a manifold assembly in which the box is placed within the housing; Figure 36 The box was placed inside the container. Figure 35 A cross-sectional view of the manifold assembly; Figure 37A This is a right front perspective view of a manifold assembly according to one embodiment; Figure 37B This is a rear left perspective view of the manifold assembly; Figure 38A This is an exploded view of the front of the manifold assembly; Figure 38B This is a cross-sectional view of the manifold assembly; Figure 38C This is a 3D view of the tongue-shaped valve unit; Figure 38D This is a cross-sectional view of the tongue-shaped valve unit; Figure 39A This is a top view of the manifold component where the tissue trap has been removed; Figure 39B This is a side view of the manifold component where the tissue trap has been removed; Figure 40A This is a top view of the box lid; Figure 40B This is a front view of the box lid; Figure 40C This is a right-side view of the box lid; Figure 40D This is a rear view of the box lid; Figure 40E This is a left-side view of the box lid; Figure 41A This is a top view of the box shell; Figure 41B This is a front view of the box shell; Figure 41C This is a right-side view of the box casing; Figure 41D This is a rear view of the box casing; Figure 41E This is a left-side view of the box casing; Figure 42A This is a top view of the tissue capture device; Figure 42B This is a front view of the tissue capture device; Figure 42C This is the right-side view of the tissue capture device; Figure 42D This is the rear view of the tissue capture device; Figure 42E This is the left-side view of the tissue capture device; Figure 43 This is an exploded perspective view of an additional embodiment of the manifold assembly; Figure 44 This is an exploded perspective view of an additional embodiment of the manifold assembly; Figure 45A yes Figure 44 A top view of the tissue capture device; Figure 45B yes Figure 44 A front view of the tissue capture device; Figure 45C yes Figure 44 The right-side view of the tissue capture device; Figure 45D yes Figure 44 Rear view of the tissue capture device; Figure 45E yes Figure 44 The left-hand view of the tissue capture device; Figure 46 This is a perspective view of another embodiment of the manifold assembly; Figure 47 yes Figure 46 Exploded view of the manifold assembly; Figure 48A It is a perspective view of a tissue trap container with an attached cap; Figure 48B It is a three-dimensional view of the tissue trap container with the cover removed; Figure 49A yes Figure 48B A front view of the tissue capture container; Figure 49B This is a bottom view of the tissue capture device housing; Figure 49C This is a side view of the tissue capture device container; Figure 49D This is a top view of the tissue capture device housing; Figure 49E This is a rear view of the tissue capture device container; Figure 50 This is a 3D view of the rinsing box assembly; Figure 51 This is a cross-sectional view of the irrigation box assembly installed inside the irrigation container; Figure 52 yes Figure 50 Exploded perspective view of the rinsing box assembly; Figure 53 yes Figure 50 Another exploded perspective view of the rinsing box assembly; Figure 54 yes Figure 50 Exploded side view of the rinsing box assembly; Figure 55 This is a top perspective view of another embodiment of the rinsing box assembly; Figure 56 This is a bottom perspective view of another embodiment of the rinsing box assembly; Figure 57 This is an exploded view of the components forming the additional alternative box of the present invention; Figure 58 yes Figure 57 A cross-sectional view of the box; Figure 59 yes Figure 57 A front view of the box; Figure 60 yes Figure 57 A cross-sectional view of the lid of the box; Figure 61A and 61B They are respectively with Figure 57 Front and rear perspective views of the screen holder used together with the box; and Figure 62 It has a screen retainer with mounting. Figure 57 A 3D view of the box. Detailed Implementation

[0013] IOverview Figure 1A A waste and tissue collection system 30 constructed according to the present invention is illustrated. System 30, sometimes referred to as a movable unit or rover, includes a base 32. Cover and door assemblies, typically used to conceal the components of the movable unit 30, are provided. Figure 1A These components are not shown in the diagram, allowing them to be seen.

[0014] Wheels 34 attached to the bottom of base 32 provide mobility for the system. Two tanks 36 and 38 are mounted to base 32. The first tank 36 has a relatively large internal volume between approximately 10 and 40 liters. The second tank, tank 38, has a smaller volume between approximately 1 and 10 liters. Each tank 36 and 38 has a lid 40 and a lid 42, respectively.

[0015] For further reference Figure 2Attached to the canister cap 42 of the canister 38 is a manifold assembly 100. The manifold assembly 100 includes a reservoir 102 and a box 200. The box 200 is removably housed within the reservoir 102. As described below, the box 200 is formed with a plurality of connectors 180 and 181. Connector 180 receives a suction line 50 and connector 181 receives an irrigation line 51. The distal end of each of the suction line 50 and irrigation line 51 is attached to a suction applicator 52. (Here, "distal" refers to the surgical site towards which suction is applied, while "proximal" refers to the area away from the surgical site.) Figure 1A In this illustration, the aspiration applicator 52 is shown as a head specifically and uniquely designed for applying aspiration and irrigation, but it should be understood that this is exemplary and not limiting. Sometimes, the aspiration applicator 52 is constructed to be applied to the surgical site to perform tasks other than applying aspiration and irrigation, such as a colonoscope or ablation tool.

[0016] Part of the movable unit 30 consists of a suction pump 58 and a peristaltic pump 70. Conduits extend from each cover 40 and 42 into the suction pipe. Figure 1A In the diagram, these suction pipes are indicated by dashed lines 60. These pipes are fluid paths through which the suction pump creates a vacuum on tanks 36 and 38 and on suction pipes that are extended to the tanks. When suction pump 58 is actuated, the resulting suction force draws material into the applicator attached to the suction pipe.

[0017] A continuous suction fluid communication path 184 is formed from the applicator 52 to the suction pump 58. Waste liquid flows from the reservoir 102 into the associated tank 36. Small solid particles of liquid and matter contained within the flowing liquid settle out of the liquid flow and into the tank 38. This waste is then stored in the tank 36 until the tank is emptied. Gas and any small particles of matter contained within the flowing liquid flow from the tank toward the suction pump 58.

[0018] An alternative manifold container 1699 is shown attached to the tank 36. The manifold container 1699 is shaped to receive another manifold (not shown) and is not part of this invention. This particular manifold container and the manifold inserted therein are disclosed in U.S. Patent No. 7,615,037, which is incorporated herein by reference.

[0019] like Figure 2 As shown, the cover 42 is formed having a solid cover head 63 projecting upward from the top surface of the base of the cover. A cavity 64 is defined within the cover head 63. A container 102 is mounted within the cavity 64. The container 102 is mounted to the cavity 64 such that the plate of the container 102 contacts the inner plate of the cover head 63. The box 200 is removably held within the container 102. A flushing connector 180 and a suction connector 181 extend distally away from the box 200.

[0020] A peristaltic pump 70 is connected to the irrigation line 51, such that rotation of the peristaltic pump 70 forces irrigation fluid from the irrigation fluid source 72 through the irrigation line 162, the cartridge 200, and the irrigation line 51 to the applicator 52, where the irrigation fluid is supplied to the surgical site. The peristaltic pump 70 includes a rotary motor 71 connected via a shaft 72 to an eccentric roller 74. The peristaltic pump 70 supplies irrigation fluid to the applicator 52, as described in more detail later. A continuous irrigation fluid communication path 182 is formed from the irrigation fluid source 72 to the applicator 52.

[0021] A linear actuator 80 is connected to the piston 300 via a connecting rod 82. The linear actuator 80 causes the rod 82 to move in a reciprocating motion toward and away from the piston 300. The piston 300 is shown positioned toward the distal end 245 of the cannula, and the tissue trap 350 is shown positioned toward the proximal end 244 of the cannula.

[0022] Figure 1B This diagram illustrates a control system 190 used to control the operation of a waste collection system 30. The control system 190 is installed within the waste collection system 30. The control system 190 includes a controller 192. The controller 192 may be a general-purpose microprocessor, microcontroller, or computer. The controller 192 communicates with and controls the operation of a suction motor 58, a pump motor 71, an actuator 80, a light source 129, a radio frequency identification (RFID) reader 194, and a control panel 196. The control panel 196 includes buttons, switches, and a display to allow the user to select, control, and observe operating parameters of the waste collection system 30.

[0023] Figure 1C The illustration shows details of an aspiration applicator 52, specifically a colonoscope 52 for a colonoscopy. The colonoscope 52 has a handle 164 connected to an elongated flexible tube 165 with an end 166. The handle 164 is connected to an irrigation fluid connection structure 167, an aspiration connection structure 168, a light source 169, and an air pump 170. The flexible tube 165 includes an aspiration channel 171, an air channel 172, a water channel 173, and a biopsy valve 174. The irrigation fluid connection structure 167 is connected to an irrigation line 51 (… Figure 1A The suction connection structure 168 is connected to the suction line 50. Figure 1A The end of the endpiece 166 is placed at the surgical site, and suction, air, or irrigation fluid is applied to the surgical site through the endpiece 166. Polyp samples can be collected or obtained from the gastrointestinal tract using a colonoscope 52. A cutting tool (not shown) is inserted through the biopsy valve 174 and the suction channel 171 to the surgical site. The cutting tool can remove and excise the polyp. The cutting tool is removed from the suction channel 171, and the polyp is removed from the excision site by suction through the suction channel 171.

[0024] II. First Embodiment A. Seat refer to Figure 3-6 The diagram illustrates a manifold assembly 100 according to a first embodiment of the present invention. The manifold assembly 100 includes a reservoir 102, a box 200, a piston 300, and a tissue trap 350.

[0025] The container 102 is shown in a generally rectangular shape. Other shapes, such as circular, elliptical, or square, may be used. The container 102 is defined by six outer plates, including parallel and spaced-apart generally horizontally oriented top and bottom plates 105 and 106; parallel and spaced-apart generally vertically oriented plates 107 and 108; and parallel and spaced-apart generally vertically oriented front plate 109 and a partial back or rear plate 110. A flange 112 extends vertically outward from the outer periphery of plates 105, 107, and 108. The flange 112 has a rear surface 114. The container 102 is formed from any suitable material, such as injection-molded plastic.

[0026] Front panel 109 defines a horizontally oriented opening 118 comprising a narrow region 119 and a wide region 120. Opening 118 extends across the width of the housing 102 and extends through the housing 102 between front panel 109 and rear panel 110. Panel 117 extends vertically away from and connects to base panel 116 to define the wide region opening 120. Base panel 116 extends between and is generally parallel to panel 106. Wide region 120 is defined by panels 105, 107, 116, and 117. Wide region 120 is integral with narrow region 119.

[0027] A generally rectangular door opening 124 is defined on the top plate 105, adjacent to the edge of the receiving seat and connected to the side plate 107. A generally rectangular irrigation opening 126 ( Figure 6 The aperture 128 is defined on the base plate 106, adjacent to the edge of the housing 102 and connected to the side plate 108. Figure 6 The flange 112 is defined adjacent to the side plate 107. A light source, such as a light-emitting diode 129, is mounted within an aperture 128 for light to pass through, illuminating the piston 300 and the tissue trap 350. The light-emitting diode 129 is connected to a power source (not shown) mounted within the cover 42. An aperture or orifice 130 ( Figure 5 It is confined to the base plate 116 and positioned toward the front plate 109.

[0028] The slender door 136 is rotatably mounted to the top plate 105 via one or more hinges 142. Figure 4 and 5The diagram only shows the top edge of door 136. Door 136 includes a top edge 138 and a wide portion 140 with an attached foot 141. The foot 141 extends vertically away from the bottom of door 136 into a wide area 120 of opening 118. Door 136 is hinged around hinge 142 as shown in the diagram. Figure 3-5 The opening position shown and as Figure 16 The door 136 rotates between the shown closed positions. In the closed position, the door 136 covers the opening 118, which includes a narrow region 119 and a wide region 120. In the closed position, the foot 141 is positioned over the suction orifice 130 to seal or close the path to the canister 38. When the door 136 is in the open position, the foot 141 extends through the door opening 124. When the box 200 is removed from or not installed in the channel 118, the hinge 142 biases the door 136 to the normal closed position.

[0029] A pair of parallel, directly opposing, slender L-shaped guides 134 (in Figure 4 (Best seen in the middle) Extends away from the base plate 106 below the rinsing opening 126. Guide rails 134 define a groove 132 between them that extends inward from the plate 108 along the rinsing opening 126 and below the rinsing opening 126. Parallel and directly opposite elongated grooves 135 are defined along the length of each guide rail 134.

[0030] refer to Figure 4 The rinsing connector 150 is in the rinsing line 162 ( Figure 1A A flushing fluid connection is provided between the flushing connector 150 and the housing 200. The flushing connector 150 has a generally rectangular body 152 with a distal end 153, a wider, integral proximal shank 154, and a pair of parallel, oppositely inclined, elongated sidewalls 156 located on opposite sides of the body 152. An outlet connector 158, formed of a compressible material, extends upward from the body 152, and an inlet port 160 extends below the body 152 toward the proximal shank 154. The inlet port 160 has a barbed end (not shown) for holding the flushing line 162. A fluid communication path extends through the body 152 between the outlet connector 158 and the inlet port 160. The flushing line 162 is connected between the inlet port 160 and the flushing fluid source 72. The flushing connector 150 can be formed of any suitable material, such as injection-molded plastic.

[0031] The flushing connector 150 is inserted into and removed from the slot 132. The user can insert the flushing connector 150 by grasping the handle 154 and guiding the distal end 153 toward the slot 132, causing the angled side 156 to engage the groove 135. By manually pushing the handle 154 toward the receiver 102, the angled side 156 slides along the groove 135 until the handle 154 contacts the guide rail 134, at which point the flushing connector 150 is fully seated in the slot 132. The flushing connector 150 can be removed by the user grasping the handle 154 and pulling it away from the slot 132.

[0032] Identification device 376 ( Figure 5 The device is attached to the rinsing connector 150. The identification device 376 can be any suitable identification device, such as a radio frequency identification (RFID) tag or device, barcode, magnetic stripe, or other storage device. The identification device may contain information such as installation information, expiration information, and information for control of reuse or reprocessing.

[0033] B. Box Figure 7-8 Figures 9A-9G and 10A-10G illustrate details of box 200. Box 200 can be formed from any suitable material, such as injection-molded plastic. See details... Figure 7-8 Box 200 is generally rectangular in shape and includes a housing 202 having two parts: an upper housing 204 and an opposing lower housing 206. Although the housing is shown as using two parts, it is contemplated that housing 202 could be formed as a single, integral part. The upper housing 204 and the lower housing 206 mate together to form housing 202. A cavity 203 is defined within housing 202 between the upper housing 204 and the lower housing 206. The upper housing 204 includes a planar top plate 207, a front plate 208, a curved back plate 210, and side plates 212, 214, and 215. Plates 208, 210, 212, 214, and 215 extend vertically away from the top plate 207.

[0034] A pair of internal support plates 218 and 219 extend between the front plate 208 and the back plate 210. The internal support plates 218 and 219 are generally parallel to each other and extend vertically away from the top plate 207. The internal support plates 218 and 219 define a flushing pipe channel 220. An opening 222 on the front plate 210 opens into the pipe channel 220. A cover 224 extends away from the side plate 214 and is coplanar with the top plate 207. The cover 224 is mechanically supported by a plurality of ribs 216 extending between the side plate 214 and the cover 224. An arm 226 extends away from the side plate 214, adjacent to the rear plate 208, and is coplanar with the top plate 207. A slot 227 is defined between the cover 224 and the arm 226.

[0035] The suction connector 180 is a 90-degree elbow connector that provides a fluid communication path and is mounted to the arm 226. The suction connector 180 has a tapered end 228 and another end 229, and a suction line 50 (…). Figure 1A The tapered end 228 is attached to and removed from therefrom. End 229 extends slightly away from arm 226. Tapered end 228 is oriented away from the front of housing 200 and end 229 is oriented toward lower housing 206. Upper housing 204 also includes a flush connector 260 located in the corner of housing 200 adjacent to plates 212 and 215. Figure 8 (See also...) Figure 9A-9G Like 10A-10G, the flushing connector 260 has a generally L-shaped body 262 with a pair of spaced flexible feet 264 extending from the body 262 and resting on the plate 207. The flushing connector 260 has a tapered outlet end or port 266 and a grooved, beveled inlet end or port 268. The outlet end or port 266 is positioned between a portion of plates 210 and 215. The flushing connector 260 forms a 90-degree bend or elbow bend and defines a fluid communication path for flushing fluid between the inlet port 268 and the outlet port 266. The body 262 is attached to the plate 212 by an active hinge 270. The active hinge is a thin, flexible hinge or flexible bearing, formed as an integral part between two components that are desired to move relative to each other. The feet 264 provide a resilient force to the body 262 for biasing the body 262 away from the plate 207.

[0036] The upper housing 204 is connected to the irrigation connector 260 extending distally from the opposite side 212. Figure 9E They are formed or molded together. In this position, the flushing connector 260 is positioned outside the upper housing 204. The body 260 can be rotated about the active hinge 270 into the cavity 203, such that the foot 264 rests on the top plate 207, while the outlet port 266 is positioned between a portion of plates 210 and 215. Figure 10E In this position, the flushing connector 260 is placed inside the upper housing 204.

[0037] Return to reference Figure 7 and 8 The lower housing 206 includes a flat base plate 230, a front plate 232, a curved back plate 234, and side plates 236. Plates 232, 234, and 236 extend vertically away from the base plate 230 and each has an inclined edge 237. A U-shaped opening 235 is provided on the front plate 232 to allow the flushing pipe end 282 to pass through. A generally elongated hollow square box-shaped sleeve 240 extends outward from the base plate 230 at its end 238.

[0038] The sleeve 240 has an outer surface 242, an inner surface 243, a proximal end 244, a distal end 245, and an aperture 246. The aperture 246 extends entirely through the sleeve 240 between the proximal and distal ends 244 and 246. A suction orifice 248 is defined on one side of the sleeve 240 toward the proximal end 244. A cartridge discharge port 250 is defined on the opposite side of the sleeve 240 toward the center of the sleeve 240.

[0039] The lower housing 206 also includes a lens 223 mounted in the top side of the sleeve 240. Figure 5 Lens 223 is a magnifying lens capable of magnifying the contents of the tissue trap 350. The user can see any tissue sample collected in the tissue trap 350 through lens 223. Pump tubing 280 includes an irrigation tube 181, ends 281 and 282, a curved roller contact section 284, and an angled section 286. After the pump tubing 280 is assembled onto the lower housing 204, the angled section 284 is placed within a groove 220 in the housing 200. Pump tubing 280 can be formed of any suitable material such as an elastomer or silicone rubber. End 281 is press-fitted to the tapered outlet end or port 266 of the irrigation connector 260. The curved roller contact section 284 is positioned adjacent to and extends along the outer surface of the curved plate 210. The angled section 286 is positioned and held between inner plates 218 and 219 of the irrigation tubing groove 220. Pump pipe 280 also extends from angled section 286 through openings 222 and 235 to end 282. Pump pipe 280 provides a fluid communication path for flushing fluid to flow from outlet port 266 to flushing connector 181.

[0040] The upper housing 204 and the lower housing 206 mate together to form the box 200. Housings 204 and 206 are held together by press-fitting, snap-fitting, or welding. Other holding mechanisms, such as adhesives, may also be used. When housings 204 and 206 are pressed together, the angled edge 237 forces plates 232, 234, and 236 to be positioned inside plates 208, 210, and 212, respectively. In the mating position, the cover 224 extends over a portion of the sleeve 240 toward the distal end 245. Also in the mating position, the arm 226 extends over a portion of the sleeve 240 toward the proximal end 244, while the end 229 of the suction connector 180 is fitted into or received within the suction orifice 248.

[0041] For further reference Figure 5The piston 300 is shown as having a generally rectangular shape. Other shapes, such as circular, elliptical, or square, may be used. The piston 300 is defined by six outer surfaces, including parallel and spaced-apart generally horizontally oriented top and bottom surfaces 302 and 303; parallel and spaced-apart generally vertically oriented surfaces 304 and 305; and parallel and spaced-apart generally vertically oriented front and rear surfaces 306 and 307. A cavity 301 is defined within the piston 300. A raised edge 308 extends outward from the front plate 306 and from surfaces 302, 303, 304, and 305 at an angle from the outer periphery. Another raised edge 310 extends outward from the rear plate 307 and from surfaces 302, 303, 304, and 305 at an angle from the outer periphery.

[0042] Piston 300 has a proximal end 318 and a distal end 319 facing the aperture 246. A generally rectangular recess 312 is defined towards the center of the top surface 302. The bottom of the recess 312 is defined by a partition (partition) 313. An aperture 314 is disposed on the partition 313 towards the distal end 319. The aperture 314 extends through piston 300 between partition 313 and bottom surface 304. Opening 316 ( Figure 8 The opening 316 is disposed on the bottom surface 303 facing the distal end 319. The opening 316 is coaxial with the aperture 314. The piston 300 is adapted to be received by the aperture 246 of the sleeve 240. The piston 300 is slidable along the inner surface 243 while the raised edges 308 and 310 contact the inner surface 243. The piston 300 can be formed from any suitable material such as an injection-molded elastomer. The piston 300 forms a seal between the raised edges 308 and 310 and the inner surface 243.

[0043] refer to Figure 11A-11E Figures 12A-12E illustrate a tissue trap 350. The tissue trap 350 is generally rectangular in shape. Other shapes, such as circular, elliptical, or square, may be used. The tissue trap 350 may be formed from any suitable material, such as a low-hardness plastic or thermoplastic elastomer. The tissue trap 350 is defined by five outer plates, including parallel and spaced-apart generally vertically oriented plates 352 and 353; parallel and spaced-apart generally vertically oriented front and rear plates 354 and 355; and a horizontally oriented base plate 356. A notch 357 is defined on plate 355. A flange 358 extends outwardly from the outer periphery from the front plate 354 and from plates 352, 353, 354, and 356. The tissue trap 350 defines a cavity 360.

[0044] A pair of directly opposite, spaced-apart centering features 362 and 364 extend distally away from the side or end 355. Centering feature 362 is positioned towards the side or end 353, while centering feature 364 is positioned towards the side or end 352. Centering features 362 and 364 are positioned at the aperture 246 of the insertion cannula 240 of the tissue trap 350. Figure 7 The tissue trap 350 is guided during the process within the plate 355. A pore 366 is defined within a base plate 356 adjacent to the interior of the plate 355. The pore 366 is in fluid communication with the cavity 360.

[0045] L-shaped screen 368 is rotatably connected to tissue trap 350 via active hinge 374. Screen 368 has a rectangular bottom portion 369 and rectangular side portions 370. The bottom portion 369 is oriented perpendicular to the side portions 370. A plurality of holes 372 are defined to pass through the bottom portion 369. Screen 368 can be positioned around hinge 374 as follows: Figure 11A-11E The closed position located within cavity 360 is shown in the figure, and as shown in the figure. Figures 12A-12E It rotates between the open positions located outside the cavity 360 as shown in the figure.

[0046] Identification device 376 (in) Figure 3 and 6 (Best viewed from the center) is attached to the side 352 of the tissue capture device 350. The identification device 376 can be any suitable identification device, such as a radio frequency identification (RFID) tag or device, barcode, magnetic stripe, or other storage device. The identification device may contain information such as installation information, expiration information, and control information for reuse or reprocessing.

[0047] Another identification device 378 (in) Figure 5 and 6 (Best viewed from the center) is attached to the cover 224 of the box 200. The identification device 378 can be any suitable identification device, such as a radio frequency identification (RFID) device, barcode, magnetic stripe, or other storage device. The identification device may contain information such as installation information, expiration information, and control information for reuse or reprocessing.

[0048] Figure 13 and 14 A specimen container or jar 380 is illustrated. The specimen container or jar 380 has a generally cylindrical shape with an outer plate 382 and a base plate 383. Two diametrically opposed, spaced-apart gripping portions 384 are disposed on the outer plate 382 of the specimen container 380. A chamber 388 is defined within the specimen container 380. In one embodiment, the chamber 388 contains a preservative solution 389, such as formalin or other suitable preservative. In another embodiment, the preservative solution is omitted. The specimen container 380 is formed of a transparent material so that the contents of the chamber 388 can be observed by the user.

[0049] An annular flange 386 extends upward and outward along the periphery from the plate 382. An annular thread 387 is defined on the outer surface of the flange 386. A circular cap 390 has an annular thread 391. The cap 390 is attached to the specimen container 380 by rotating the cap 390 relative to the specimen container 390 to engage the threads 387 and 391.

[0050] The cap 390 is removably held to the specimen container 380 via the cap holder 392. The cap holder 392 has an elongated arm 395 with a proximal end 396 removably attached to a flange 386 and a distal end 397 attached to an arcuate rib 393. The rib 393 is connected to the cap 390 via a protrusion 394. The protrusion 394 provides a weak connection between the rib 393 and the cap 390.

[0051] The user places the cap 390 onto the specimen container 380. The cap holder 392 aligns threads 387 and 391. As the cap 390 is rotated relative to the specimen container 380, the protrusion 394 disengages, separating the cap 390 from the cap holder 392. The user can then pull the arm 395 to remove the cap holder 392 from the specimen container 380.

[0052] like Figure 14 As shown, a user can place the tissue trap 350 containing the tissue sample 398 into the compartment 388, thereby immersing the tissue trap 350 and the tissue sample 398 under the preservative solution 389. The tissue sample 398 can be a variety of tissue specimens. For example, the tissue sample 398 can be a biopsy sample from a body part or a polyp from the colon. The cap 390 is then screwed onto the specimen container 380 to seal the tissue sample 398 and the tissue trap 350 within the specimen container 380.

[0053] C. Operation of the First Embodiment Referring to Figures 1-14, the movable unit 30 (Figure 1) is prepared for use by the user inserting the cassette 200 into the complementary receptacle 102 associated with the tank 38 of the manifold assembly 100. This step is performed by inserting the cassette 200 into the receptacle 102, causing the back panel 215 to open the door 136. When the door 136 is opened, the foot 141 extends through the opening 124. The cassette 200 slides into the channel 118 until the back panel 215 contacts the rear plate 110. In this position, the cassette discharge port 250 ( Figure 8 The pump is positioned against and in fluid communication with the suction conduit 59. The curved conduit section 284 is pressed against the peristaltic pump roller 74, causing the rotation of the roller 74 to force the flushing fluid through the pump conduit 280.

[0054] When the cartridge 200 is inserted into the container 102, the RFID reader 194 identifies the RFID tag 376 of the inserted cartridge 200 and sends a signal to the controller 192 to allow the movable unit 30 to operate. After the cartridge 200 is inserted into the container 102, the controller 192 actuates the light source 129 to illuminate the piston 300 and the tissue trap 350.

[0055] The flushing line 162 connects the flushing fluid source 72 and the flushing connector 150. The flushing connector 150 is inserted into the groove 132. The user inserts the flushing connector 150 by grasping the handle 154 and guiding the distal end 153 toward the groove 132 to engage the inclined side 156 with the groove 135. Continue pushing the handle 154 manually toward the reservoir 102 to slide the inclined side 156 along the groove 135 until the flushing connector 150 is fully seated in the groove 132. In this position, the outlet connector 158 forms a connection through the flushing connector 260 to the pump line 280. The outlet connector 158 is then in fluid communication with the pump line 280. The movable unit 30 is completed for use by attaching the suction line 50 to the connector 180 and the irrigation line 51 to the connector 181, thereby engaging the applicator 52, such as a colonoscope, to the unit.

[0056] By positioning the piston 300 within the sleeve 240, the housing 200 is selected into an operating mode. The piston 300 is initially positioned as follows: Figure 3 The position shown is such that piston 300 is located within the distal end 244 of sleeve 240. This is the bypass position. In this bypass position, piston 300 is aligned such that recess 312 is aligned below end 229 of connector 180 and orifice 314 is aligned with orifice box discharge port, thus allowing fluid to flow through piston 300.

[0057] The movable unit 30 is actuated by an actuation pump 58 and a peristaltic pump 70. Actuation of the actuation pump 58 causes waste fluid to be drawn from the surgical site into the applicator 52 along the actuation fluid communication path 184, through the actuation line 50, and into the connector 180. From the connector 180, the waste fluid flows through the piston, specifically through the groove 312, into the orifice 314, and through the hollow internal cavity 301. The waste then flows out through the piston orifice 316 and the cartridge discharge port 250 into the conduit 59. Through the conduit 59, the waste fluid flows into the canister 38. This operating mode is called the bypass mode because the actuation fluid communication path 184 bypasses the tissue trap 350.

[0058] The liquid and solid components of the waste liquid stream entering tank 36 or 38 are separated from the liquid stream and retained in tank 36 and 38 for final treatment.

[0059] The actuation of the peristaltic pump 70 causes the irrigation fluid to be pumped from the irrigation source 72 along the irrigation fluid communication path 182, through the irrigation line 162, irrigation connector 150, pump tube 280, irrigation connector 181, and irrigation line 51 into the applicator 52 for application at the surgical site.

[0060] Users can choose to use cartridge 200 to collect tissue samples, such as polyps. By repositioning piston 300 within cannula 240, cartridge 200 is placed in tissue collection mode.

[0061] The user manually inserts the tissue catcher 350 into the sleeve 240, causing the piston 300 to be displaced distally away from the screen 350 and further inserted into the sleeve 240. Centering features 362 and 364 guide the tissue catcher 350 into the flange 308 of the piston 300 and into contact with the plate 306.

[0062] This location is Figure 2 As shown, the piston 300 is positioned toward the proximal end 245 of the sleeve 240. When the tissue trap 350 is fully inserted into the sleeve 240, the flange 358 abuts against the proximal end 244 of the cartridge. This is the tissue collection position. In the tissue collection position, the tissue trap 350 is aligned such that the cavity 360 is aligned below the opening of the connector 180 and the orifice 366 is aligned with the cartridge discharge port 250, thereby allowing fluid to flow through the piston tissue trap 350. In the tissue collection position, the piston 300 is not part of the fluid communication path.

[0063] When the system is in tissue collection mode, waste fluid is aspirated from the surgical site into the applicator 52 along the aspiration fluid communication path 184, through the aspiration line 50, and into the connector 180. This waste fluid stream includes tissue sample 398 contained within the aspiration applicator 52 due to the suction force passing through the applicator. Starting from the connector 180, the waste fluid stream passes through the cavity 360, the screen 368, the pores 366 and 250 into the conduit 59. After passing through the conduit 59, the waste fluid stream flows into the container 38. Tissue sample 398 is captured by the screen 368 in the tissue trap 350. This operating mode is called tissue collection mode because the aspiration fluid communication path 184 passes through the tissue trap 350. Note that it is not necessary to disconnect or reconnect the aspiration line 50 to collect samples in tissue collection mode.

[0064] The plastic forming the tissue trap 350 is at least partially transparent to allow the user to observe the tissue sample 398. The tissue sample 398 is illuminated within the tissue trap 350 by the light source 129.

[0065] The tissue catcher 350 is removed from the sleeve 240 by the user actuating the linear actuator 80. Alternatively, the tissue catcher 350 can be removed by the user manually pulling it or by using an operating lever or spring mechanism (not shown). The user presses a button on an input device such as a control panel 196 to actuate the actuator 80. The actuator 80 linearly drives the shaft 82, pushing the piston 300 and causing it to move from the proximal end 245 of the sleeve 240 toward the distal end 244. The movement of the piston 300 causes the tissue catcher 350 to move out of the orifice 246 of the sleeve 240, allowing the user to grasp the tissue catcher 350. As the piston returns to the proximal position, the system is considered to have returned to bypass mode.

[0066] If, later in the procedure, the physician deems it useful to collect another tissue sample, a second trap 350 can be inserted into the aperture 246 of the cannula 240 to collect that additional tissue sample. Multiple tissue samples can be collected using multiple tissue traps 350. During the procedure, multiple tissue samples can be collected without disconnecting or reconnecting the aspiration suture 50.

[0067] It should be recognized that another feature of the invention is that the system can switch between a bypass operation mode and a tissue collection operation mode without necessarily deactivating the aspiration pump during this transition. This means that when using the invention for tissue collection, the overall duration of the procedure is not increased because the time spent repeatedly switching the aspiration pump 58 on and off is not required.

[0068] After removing the tissue trap 350 from the box 200, the user places the tissue trap 350 into the specimen container 380, where it is immersed in preservative 389, thus... Figure 14 The cover is shown as tissue sample 398. The user places the cap 390 onto the specimen container 380. The cap holder 392 aligns threads 391 and 387. As the cap 390 is rotated onto the specimen container 380, the protrusion 394 disengages, separating the cap 390 from the cap holder 392. The user can pull the arm 395 to remove the cap holder 392 from the specimen container 380. The specimen container 380 is then sent to a pathology laboratory for analysis.

[0069] Once the medical / surgical procedure is complete and the movable unit 30 is no longer needed, the suction line 50 and irrigation line 51 can be disconnected from connectors 180 and 181 respectively, while the irrigation connector 150 can be disconnected from the containment seat 102. The cassette 200 is removed from the containment seat 102. After the cassette 200 is removed from the containment seat 102, the door 136 closes the passage 118. When the door 136 is in the closed position, the foot 141 covers the catheter 59, sealing the entrance to the catheter 59. The closure of the passage 118 effectively eliminates leakage of any waste material retained in the containment seat 102. The cassette 200 is disposed of as medical waste.

[0070] After use, the movable unit 30 is engaged with a docker (not shown in the figure and not part of the invention). Waste material in tanks 36 or 38 flows through the docker into the treatment facility.

[0071] The outlet connector 158 forms a seal with the body 262 at the inlet port 268. These components are sized such that, when mated, the feet 264 apply an elastic force to the body 262, biasing the inlet port 268 onto the outlet connector 158. These components press against each other, creating a substantially impermeable barrier between them. This eliminates the need for O-rings or other sealing elements. This simplifies the manufacture of the housing 200.

[0072] It should also be recognized that, in this form of the invention, the plastic forming the tissue trap 350 and the specimen container 380 is at least partially transparent. This provides medical personnel with a quick means of confirming that a tissue sample has been collected. Another container 200 is made of a material that is at least partially transparent. This provides medical personnel with a quick means of confirming that the container has not been previously used and does not contain previously collected waste.

[0073] III. Second Embodiment A. Seat Referring now to Figures 15-17, details of a second manifold assembly 400 that can be used as part of the waste and tissue collection system of the present invention are illustrated. The manifold assembly 400 includes a reservoir 410, a box 420, and a tissue trap 598. The tissue trap 598 includes a specimen container 650 housing a tissue filter 600. The reservoir 402 is similar to the reservoir 102 described in the first embodiment. The reservoir 410 in the second embodiment has different dimensions from the reservoir 102, including height, length, and width. The reservoir 410 also includes a curved rear plate 402 defining a recess 404 on the distal side of the rear plate 402. The door 136 of Figure 15 does not include... Figure 3 The foot 141 is shown in the housing 102.

[0074] For further reference Figure 1A and 15BAttached to the canister cap 42 of the canister 38 is a manifold assembly 400. The manifold assembly 400 includes a reservoir 410 and a box 420. The box 420 is removably housed within the reservoir 410. As described below, the box 420 is formed by a plurality of connectors 490 and 181. Connector 490 receives a suction line 50 and connector 181 receives an irrigation line 51. The distal end of each of the suction line 50 and irrigation line 51 is attached to the aspiration applicator colonoscope 52. (Here, "distal" means toward the surgical site to which aspiration is applied, and "proximal" means away from the surgical site.) Figure 1A In this illustration, the aspiration applicator 52 is shown as a head specifically and uniquely designed for applying aspiration and irrigation, but it should be understood that this is exemplary and not limiting. Sometimes, the aspiration applicator 52 is constructed to be applied to the surgical site within another surgical tool, such as a colonoscope or ablation tool, to perform tasks other than applying aspiration and irrigation.

[0075] Inside the cover 42 is a conduit 59. The conduit 59 serves as a fluid communication path from the container 410 into the tank 36 or 38 associated with the container. A suction fluid passage 454 within the box 420 exits from the rear of the box 420 and the container 410 and enters the horizontally oriented conduit 59 located behind the cavity 64.

[0076] Suction pump 58 and peristaltic pump 70 are also part of movable unit 30. Conduits 59 and 60 (in...) Figure 1A (Indicated by dashed lines) Each tank 36 and 38 is connected to the inlet port of the suction pump 58. When the suction pump 58 is actuated, the resulting suction force draws the material into the applicator 52 and through the associated suction line 50, box, and container.

[0077] A continuous suction fluid communication path 184 is formed from the applicator 52 to the suction pump 58. Waste liquid flows from the container 410 into the associated tank 36. Liquid and small solid particles contained in this flow precipitate from the flow into the tank 38. Thus, the waste is stored in the tank 36 until the tank is emptied. Gas or any small particles contained in this flow flow move from the tank toward the suction pump 58.

[0078] like Figure 2 As shown, the cap 42 is formed with a solid cap head 63 protruding upward from the top surface of the base of the cap. A cavity 64 is defined within the cap head 632. A container 410 is mounted within the cavity 64. The container 410 is fastened to the cavity 64 in such a way that the plate of the container 410 contacts the inner plate of the cap head 63. A box 420 is removably held within the container 410. A flushing connector 180 and a suction connector 490 extend distally away from the box 420.

[0079] A peristaltic pump 70 is engaged with an irrigation line 51, such that rotation of the peristaltic pump 70 forces irrigation fluid from an irrigation fluid source 72 through irrigation line 162, cartridge 200, and irrigation line 51 to an applicator 52, where it is applied to the surgical site. The peristaltic pump 70 includes a rotary motor 71 connected to an eccentric roller 74. The peristaltic pump 70 supplies irrigation fluid to the applicator 52, as described in more detail later. A continuous irrigation fluid communication path 182 is formed from the irrigation fluid source 72 to the applicator 52.

[0080] B. Box For further reference Figure 18A -F and 19, Box 420 is generally square in shape and includes a housing 422 having two parts, an upper housing 424 and an opposing lower housing 426. Although the housing is shown as using two parts, it is contemplated that housing 422 could be formed from a single integral part. The upper housing 424 and the lower housing 426 mate together to form housing 422. A cavity 423 is defined within housing 422 between the upper housing 424 and the lower housing 426. The upper housing 424 includes a planar top plate 427, a front plate 428, a curved back plate 430, and side plates 432 and 434. Plates 428, 430, 432, and 434 extend vertically away from the top plate 427. A nose 435 extends outward from the center of the front plate 428. A U-shaped opening 436 facing plate 432 is disposed on the front plate 428. A U-shaped opening 437 facing plate 434 is disposed on the front plate 428. A U-shaped opening 438 is provided on the nose 435. A U-shaped opening 439 is provided on the back plate 430. The box 420 is formed from any suitable material such as injection-molded plastic.

[0081] The lower housing 426 includes a flat bottom plate 442, a front plate 444, a curved back plate 446, a back plate 450, and side plates 447 and 448. Plates 444, 446, 447, and 448 extend vertically away from the bottom plate 442 and have inclined edges 449, except for the back plate 446.

[0082] A pair of internal support plates 452 and 453 extend between the front plate 444 and the back plate 450, adjacent to and spaced apart from plate 448. The internal support plates 452 and 453 are generally parallel to each other and extend vertically away from the bottom plate 442. The internal support plates 452 and 453 define a channel 454. The support plates 452 and 453 each have ends 456 and 457 that are formed at a 90-degree angle adjacent to and slightly spaced apart from plate 444, and the ends 456 and 457 extend parallel to plate 444 and terminate at an end 459 toward the center of plate 444. An aperture 458 is provided on the back plate 450 and is in fluid communication with the channel 454. An aperture 478 extends through the bottom plate 442 at end 459. The aperture 478 is in fluid communication with the channel 454. A second suction connector 490 extends through the front plate 444 and extends outwardly from the front plate 444. The second suction connector 490 is in fluid communication with the channel 454. The second suction connector 490 is engaged with an optional second suction line (not shown) and is sealed with a cap 491 (Fig. 15) when not in use.

[0083] Another pair of internal support plates, 460 and 461, extend in a meandering manner between the curved back plate 446 and a position adjacent to and spaced apart from plate 447. Internal support plates 460 and 461 are spaced approximately equally from each other and extend perpendicularly away from the base plate 442. Internal support plates 460 and 461 define a first irrigation conduit channel 462.

[0084] Another pair of internal support plates, 464 and 465, extend a short distance between the curved back plate 446 and the position adjacent to plate 447. Internal support plates 464 and 465 are generally parallel and extend perpendicularly away from the base plate 442. Internal support plates 464 and 465 define a second irrigation conduit channel 466.

[0085] Identification device 376 ( Figure 16 The identification device 376 is attached to the top plate 427 of the upper housing 424. The identification device 376 can be any suitable identification device, such as a radio frequency identification (RFID) device, barcode, magnetic stripe, or other storage device. The identification device may contain information such as installation information, expiration information, and control information for reuse or reprocessing.

[0086] refer to Figure 19 A generally rectangular opening 468 is provided on the front panel 444. A flushing connector 470 is provided in the corner of the housing 420 adjacent to the panel 447 and the opening 468. The flushing connector 470 has a panel 472 extending vertically upward from the base panel 442. A tapered nozzle 474 extends away from the panel 472 in a distal direction, and a tapered nozzle 475 extends away from the panel 472 toward the opening 468 in a proximal direction. A flushing connector 512 extends through the opening 468 and connects to the nozzle 475.

[0087] A circular protrusion 480 extends outward from the front plate 444 and downward from the bottom plate 442. The protrusion 480 has a generally horizontal top plate 482 and a generally vertical curved side plate 484. The side plate 484 is perpendicular to the top plate 482. The side plate 484 and the top plate 482 define an annular cavity 488 therein. Figure 17 Connector 486 extends upward from top plate 482 and outward from side plate 484. Tissue sedimentation port 489 extends through top plate 482.

[0088] return Figure 18A -F, The meandering pump tube 500 has ends 502 and 504, sections 505 and 506, and a curved pump section 508. The pump tube 500 is held between the upper housing 424 and the lower housing 426 within the housing 420. The pump tube 500 can be formed of any suitable material such as plastic or silicone rubber. Ends 504 are press-fitted onto a conical nozzle 474. Section 505 is positioned and held between inner plates 460 and 461 of channel 462. Section 506 is positioned and held between inner plates 464 and 465 of channel 466. The curved pump section 508 is arranged adjacent to and extends along the outer surface of the back plate 446. Rotating peristaltic pump roller 74 ( Figure 2 The end 502 is adapted to be movably pressed onto the curved pump section 508 and pressed between the pump roller 74 and the curved back plate 446. The end 502 is press-fitted onto a 90-degree elbow joint 514. The elbow joint 514 is disposed inwardly adjacent to the plate 447. The elbow joint 514 bends downward to meet the orifice 510 ( Figure 17 The pump tube 500 extends through plate 426 at point 150. The pump tube 500 provides a fluid communication path for the flushing fluid from flushing connector 150 to flushing joint 512.

[0089] An elongated L-shaped cap 516 rests on plates 452, 453, 456, and 457 and provides a fluid seal for channel 454. Cap 516 has a top plate 517 and side plates 518. Side plates 518 extend above and partially downward along plates 452, 453, 456, and 457. Cap 516 has a proximal end 519 positioned toward a back plate 450 and a distal end 520 positioned toward a front plate 444. A conduit 522 is positioned below the top plate 517 at the distal end 520. Conduit 522 is positioned through an orifice 458 and extends into channel 454. Conduit 522 is in fluid communication with channel 454.

[0090] The upper housing 424 and the lower housing 426 mate together to form the housing 422 of the box 420. Housings 424 and 426 are held together by press-fitting or snap-fitting. Alternatively, housings 424 and 426 are held together by adhesive or welding. When housings 424 and 426 are pressed together, the angled edge 450 forces plates 444, 447, and 448 to be positioned inside plates 428, 432, and 434, respectively.

[0091] Box 420 also includes valve assembly 530. Valve assembly 530 includes valve member 532, retaining ring 560, and knurled pushbutton 580. Figure 20A-20D As shown, valve member 532 has a generally cylindrical shape, with a top surface 534, a bottom surface 535, and a side surface 536. An edge 537 extends outward from the outer periphery of the top surface 534 and extends slightly above the side surface 536. A pair of opposing, parallel, spaced-apart steps 538 are defined on the bottom surface 535. Orifices 540 and 542 extend through the space between the top surface 534 and the bottom surface 535 of valve member 532. A curved groove 544 is defined on the top surface 534 and coextensively extends with the orifice 542.

[0092] A bypass passage 550 is defined on a top surface 534 and extends substantially across the width of the top surface 534. The bypass passage 550 is defined by a central groove 552 and partial orifices 554 and 556. Partial orifices 554 and 556 extend partially into the valve member in a manner perpendicular to the top surface 534. The central groove 552 extends together with partial orifices 554 and 556.

[0093] refer to Figure 19 The ring 560 has an upper outer surface 562 and a tapered lower outer surface 564, an edge 565, an inner surface 566, a bottom side surface 567, and an annular step 568. A hole 570 is defined within the ring 580. The annular step 568 extends partially into the hole 570.

[0094] The knurled button 580 includes a base plate 582 and an annular side plate 584. The side plate 584 extends vertically from the base plate 582. A series of knurled portions or ribs 585 extend from the outer periphery around the outer surface of the side plate 584. Users can grasp the knurled portions or ribs 585 with their hands. An opening 586 is defined in the base plate 582. A recess 587 is defined in the front surface of the side plate 584. A notch 589 is defined on the front surface of the side plate 584 above the recess 587. A series of protrusions 588 extend vertically upward from the base plate 582 and are arranged in an array around the circular opening 586. The protrusions 588 are flexible and slightly inclined inward toward the opening 586. A lip 590 is provided at the distal end of each protrusion 588 and extends inward from the protrusion 588. A pair of opposing, spaced-apart L-shaped guides 592 (in) Figure 17 (See) It extends below the bottom surface of the base plate 582.

[0095] Referring now to Figures 15, 17, 19, and 20A, valve assembly 530 is attached to protrusion 480. Valve member 532 is positioned within cavity 488 with its top surface 534 adjacent to the bottoms of plates 482 and 442. Edge 537 contacts the inner side of plate 484. An annular step 568 of ring 560 surrounds and contacts the annular step 538 of valve member 532. Inner surface 566 of ring 560 contacts the outer side of plate 484. Base plate 582 supports bottom 567 of ring 560. Bottom surface 535 extends through opening 586. Protrusion 588 clamps ring 560, while lip 590 extends above edge 565.

[0096] When button 580 is pressed against ring 560, protrusion 588 bends outward and slides in contact with surfaces 562 and 564 until lip 590 moves onto edge 565, and protrusion 588 bends inward to clamp ring 560. Protrusion 588 presses ring 560 against convexity 480, while holding valve assembly 530 to housing 422. Valve assembly 532 is rotated by the user gripping button 580, thus rotating the entire valve assembly 530 relative to convexity 480.

[0097] refer to Figure 21A-21F The image shows a tissue filter 600. The tissue filter 600 is generally cylindrical in shape. Other shapes, such as circular, oval, or square, may be used. The tissue filter 600 may be formed from any suitable material, such as low-hardness plastics or thermoplastic elastomers. The tissue filter 600 may be formed from a transparent material, allowing the contents to be seen by the user. The tissue filter 600 is defined by a top plate 602. An annular side plate 604, with a diameter smaller than the top plate 602, extends vertically away from the bottom of the top plate 602 and defines a circumferential flange 606. A lip 611 extends outwardly from the bottom of the side plate 604 from the outer periphery. Figure 17The best view is achieved from the center. The curved, vertically oriented side plates 608 and 609 hang downwards from the annular side plate 604. The U-shaped, spaced-apart, vertically oriented plates 610 hang downwards from the annular side plate 604.

[0098] Plates 608, 609 and 610 define the storage device 612 ( Figure 22D In one embodiment, the reservoir 612 may contain a corrosion inhibitor 389. Figure 22D For example, formalin or other suitable preservatives. In another embodiment, the preservative is omitted. The preservative 389 is sealed within the reservoir 612 by a foil or plastic seal 614.

[0099] U-shaped, spaced-apart, vertically oriented plates 610 define a rectangular cavity 616. A rectangular screen 618 is installed within the cavity 616 and attached to plates 608 and 610. The screen 618 is slightly spaced apart from its distal end 620 within the cavity 616. An opening 622 is provided in the top plate 602 and is continuous with the cavity 616.

[0100] The circumferential flange 606 has a pair of parallel edges 623 and 624 disposed on opposite sides of the top plate 602 and a pair of curved edges 626 and 627 disposed on opposite sides of the top plate 602. A protrusion 630 extends upward from the flange 606 adjacent to the edge 627. The protrusion 630 is an alignment feature that prevents the tissue filter 600 from being inserted rearward into the valve assembly 530. After the tissue filter 600 is inserted into the valve assembly 530, the protrusion 630 reaches into the recess 589.

[0101] The conduit 632 has a proximal end 634 and a distal end 636. The conduit 632 is oriented generally parallel to and partially surrounded by the plate 609. The proximal end 634 extends through the side plate 604 and terminates at the top plate 602. The distal end 636 extends slightly beyond the end 620 and extends below the end 620. An aperture 638 extends through the conduit 632.

[0102] Figures 22A-22D The specimen container or jar 650 is illustrated. The specimen container or jar 650 has a generally cylindrical shape and includes an outer plate 652 and a base plate 653. On opposite sides of the specimen container 650, a pair of directly opposing, spaced-apart planar gripping portions 654 are provided on the outer plate 652. A chamber 658 is defined within the specimen container 650. The specimen container 650 is formed of a transparent material, allowing the contents of the chamber 658 to be seen by the user through a single flat wall. The planar shape of this wall substantially eliminates visual distortion of the contents of the chamber.

[0103] An annular flange 666 extends upward and outward from the outer periphery of plate 652. An annular thread 668 is defined on the outer surface of flange 666. A circular cap 680 has an annular thread 682 provided on the inner surface of side plate 683. The cap 680 is attached to specimen container 650 by rotating the cap 680 relative to specimen container 650, thereby engaging threads 668 and 682.

[0104] The cap 680 is removably held to the specimen container 650 via a cap retainer 683. The cap retainer 683 has an elongated arm 685 with a proximal end 686 removably attached to a flange 666 and a distal end 687 attached to an arcuate rib 693. The rib 693 is connected to the cap 680 via a protrusion 694. The protrusion 694 provides a weak connection between the rib 693 and the cap 680.

[0105] Identification device 376 is attached to cover 680. Identification device 376 can be any suitable identification device, such as a radio frequency identification (RFID) device, barcode, magnetic stripe, or other storage device. The identification device may contain information such as: installation information; expiration information; patient or specimen tracking information; and data related to reuse or reprocessing.

[0106] Tissue sample 398 can be a variety of tissue specimens. For example, tissue sample 398 can be a biopsy sample from a body part or a polyp from the colon. Tissue filter 600 will slide into compartment 658 until lip 611 engages side plate 652, thereby providing resistance to further insertion of tissue filter 600 into compartment 658.

[0107] Tissue trap 598 is removably connected to valve assembly 530. Traps 623 and 624 are inserted by horizontally pushing tissue filter 600 and specimen container 650 into recess 587, causing them to slide along and within L-shaped guide rail 592. Tissue trap 598 hangs below valve assembly 530. Tissue trap 598 is removed from valve assembly 530 by horizontally pulling tissue filter 600 and specimen container 650 away from valve assembly 530, causing them to slide out of L-shaped guide rail 592. Tissue trap 598 is then inserted into and removed from cartridge 420 as a single unit.

[0108] The user places the cap 680 onto the tissue filter 600. The cap retainer 683 aligns threads 668 and 682. As the cap 680 rotates relative to the specimen container 650, the inner surface 696 of the cap 680 contacts the top plate 602. The rotation of the cap 680 forces the tissue filter 600 downward into the compartment 658. The side plates 604 and the lip 611 bend inward and slide along the plate 652 of the specimen container until the distal end 636 contacts the bottom plate 653. As the tissue filter 600 moves downward into the compartment 658, the tip 698, fitted to the bottom plate 653, penetrates the foil or plastic seal 614, releasing preservative solution 389 to cover the tissue sample 398, as shown in... Figure 17 What I saw in the video.

[0109] When the cap 680 is rotated onto the specimen container 650, the protrusion 694 disengages, causing the cap 680 to separate from the cap holder 683. The user can then pull the arm 685 to remove the cap holder 683 from the specimen container 650.

[0110] C. Operation refer to Figure 1A -C and 15-19, by inserting the box 420 into the complementary receptacle 410 associated with the tank 36 or 38 of the manifold assembly 400, the movable unit 30 ( Figure 1A The waste aspirated from the surgical site is prepared and collected into container 36 or 38. This step is performed by inserting the cassette 420 into the reservoir 410, causing the back plate 431 to open the door 136. The cassette 420 slides into the channel 118 until the back plate 431 contacts the back plate 110. In this position, the catheter 522 rests against the aspiration catheter 59 and is in contact with the aspiration catheter 59. Figure 15B Fluid communication is achieved. A curved pipe section 508 is pressed against the peristaltic pump roller 74, causing the roller 74 to rotate and force flushing fluid through the pump pipe 500. When the housing 420 is placed within the container 410, the RFID reader 194 identifies the identification device 376, such as an RFID tag, and sends a signal to the controller 192 to allow operation of the movable unit 30.

[0111] The flushing line 162 is connected between the flushing fluid source 72 and the flushing connector 150. The flushing connector 150 is inserted into the groove 132. The user inserts the flushing connector 150 by grasping the handle 154 and guiding the distal end 153 toward the groove 132 to engage the inclined side 156 with the groove 135. By manually pushing the handle 154 toward the receiver 102, the inclined side 156 slides along the groove 135 until the flushing connector 150 is fully seated in the groove 132. In this position, the connector 158 forms a connection through the orifice 510 to the elbow connector 514. Thus, the outlet connector 158 is in fluid communication with the pump tubing 500.

[0112] The suction line 50, integrated with the suction applicator 52, is attached to the connector 486. If the suction applicator is also capable of providing flushing fluid, the flushing line 51 is attached to the connector 512. The housing 420 is set to this operating mode by setting the button 580. This causes the valve member 532 to rotate accordingly. Normally, the button 580 is set to rotate the valve member 532 to the bypass position. In the bypass position, the valve member 532 is arranged such that the orifice 554 aligns with the outlet of the connector 486 inside the protrusion 480. Simultaneously, this causes the valve member orifice 556 to align with the protrusion orifice 478. During suction, fluid flows out of the connector 486, thus allowing fluid to flow through the bypass passage 550.

[0113] The movable unit 30 is actuated by an actuation pump 58. Actuation of the actuation pump 58 causes a waste fluid flow to be drawn from the surgical site into the applicator 52 along the actuation fluid communication path 184, through the actuation line 50, and into the connector 486. This waste flow includes liquid and solid waste aspirated onto the applicator 52, as well as air adjacent to the applicator 52. When the container is in the bypass mode described above, the waste moves from the connector 486 through the bypass channel 550, through the orifice 478 into the channel 454, and through the conduit 522 into the conduit 59. After passing through the conduit 59, the waste fluid flow flows into the container 38.

[0114] Actuation of the peristaltic pump 70 causes the irrigation fluid to be pumped from the irrigation source 72 along the irrigation fluid communication path 182 through the irrigation line 162, the irrigation connector 150, the pump tube 500, the irrigation connector 472, the irrigation joint 512, the irrigation line 51 and into the applicator 52 applied at the surgical site.

[0115] The user can choose to use cassette 420 to collect tissue samples, such as polyps. By turning handle 580, cassette 420 is placed in tissue collection mode. This causes valve member 532 to rotate accordingly. When valve member 532 is in the tissue collection position, the valve member is aligned such that valve member orifice 540 aligns with the opening of connector 485 within protrusion 480. Positioning the valve member in this position also aligns valve member orifice 542 with orifice 478.

[0116] When the system is in tissue collection mode, waste and the contained tissue sample are aspirated from the surgical site into the applicator 52 along the aspiration fluid communication path 184, through the aspiration line 50, and into the connector 486. After passing through the connector 486, the waste stream moves through the aperture 540, cavity 616, screen 618, aperture 638, aperture 542, groove 545, and pore 478 into the channel 454 and through the conduit 522 into the conduit 59. From the conduit 59, the waste stream flows into the tank 38. The tissue sample 398 is captured by the screen 618 within the tissue filter 600. This operating mode is called tissue collection mode because the aspiration fluid communication path 184 passes through the tissue filter 600. Note that it is not necessary to disconnect or reconnect the aspiration line 50 to collect samples in tissue collection mode.

[0117] The cassette 420 and tissue trap 598 can also be used to collect tissue extracted from a patient's body using instruments such as forceps. To perform this collection, button 580 is turned to the extracted tissue capture mode. Turning the button to the position associated with this mode causes valve member 532 to rotate, aligning orifice 540 with tissue deposition port 489. Groove 544 aligns with orifice 478. Valve member orifice 542 aligns with orifice 478, and tissue deposition port 489 aligns with groove 544. When valve member 532 is in this position, no suction force is aspirated through connector 486. Suction force is applied across tissue deposition port 489 to aspirate from the surrounding environment.

[0118] When the system is in the tissue capture mode, the instrument used to extract the tissue is withdrawn from the patient. The distal end of the instrument with the attached tissue is inserted into the tissue deposition port 489. The suction force through port 489 tears the tissue off the instrument and draws it into the tissue capture container 650. As all the tissue is drawn into container 650, tissue removal from the container is blocked by the tissue filter 600.

[0119] Tissue catcher 598 is removably engaged to valve assembly 530. Before removing tissue catcher 598, button 580 is turned back to the bypass position to remove filter 600 and specimen container 650 from the aspiration communication path.

[0120] Tissue trap 598 is removed from cartridge 420 as a single unit. Tissue filter 600 and specimen container 650 are removed from valve assembly 530 by horizontally pulling away from valve assembly 530. Another tissue trap 598 can be inserted to collect another tissue sample by horizontally pushing capture container 650 into recess 587, causing edges 623 and 624 to slide into L-shaped guide rails 592. Button 580 is then turned back to the tissue sample collection position to collect another tissue sample. Multiple tissue samples can be collected using multiple tissue traps 600.

[0121] The suction pump 58 does not need to be turned off during the removal of a tissue trap 598 from the cartridge 420 and the attachment of a new trap 598. In other words, the new tissue trap 598 can be attached to the cartridge 420 without interrupting the suction force applied to the suction applicator.

[0122] The user places the cap 680 onto the tissue filter 600. The cap retainer 683 aligns threads 668 and 682. As the cap 680 rotates relative to the specimen container 650, the inner surface 696 of the cap 680 contacts the top plate 602. The rotation of the cap 680 forces the tissue filter 600 downward into the compartment 658. The side plates 604 and the lip 611 bend inward and slide along the plate 652 of the specimen container until the distal end 636 contacts the bottom plate 653. As the tissue filter 600 moves downward into the compartment 658, the tip 698 mounted on the bottom plate 653 punctures the foil or plastic seal 614 to release the preservative solution 389, thus covering the tissue sample 398. Figure 17 As shown in the image.

[0123] When the cap 680 is rotated onto the specimen container 650, the protrusion 694 disengages and separates the cap 680 from the cap holder 683. The user can then pull the arm 685 to remove the cap holder 683 from the specimen container 650.

[0124] Once the medical / surgical procedure is complete and the movable unit 30 is no longer needed, the suction line 50 and irrigation line 51 can be disconnected from connectors 486 and 512 respectively, while the irrigation connector 150 can be disconnected from the containment seat 410. The cassette 420 is removed from the containment seat 102. After the cassette 420 is removed from the containment seat 410, the door 136 closes the passage 118. Closing the passage 118 effectively eliminates leakage of any waste material retained in the containment seat 410. The cassette 420 is disposed of as medical waste.

[0125] The outlet connector 158 and the base plate 426 form a seal at the orifice 510. These components are sized such that when mated together, the outlet connector 158 presses against the base plate 426. The components are pressed against each other, creating a substantially impermeable barrier between them. Therefore, the need for O-rings or other sealing elements is eliminated. This simplifies the manufacture of the housing 420.

[0126] It should also be recognized that in this form of the invention, the plastic forming the tissue filter 600 and the specimen container 650 is at least partially transparent. This provides medical personnel with a quick means of verifying that a tissue sample has been collected. Additionally, the box 420 is made of a material that is at least partially transparent. This provides medical personnel with a quick means of verifying that the box has not been previously used and does not contain previously collected waste.

[0127] IV. Third Embodiment A. Seat refer to Figure 23-25 The diagram illustrates a third manifold assembly 700 that can be used as part of the waste and tissue collection system of the present invention. The manifold assembly 700 includes a container 702 and a housing 800. The container 702 is shown in a generally square shape. Other shapes, such as circular / elliptical or square, may be used.

[0128] The receiver 702 is defined by five outer plates, including parallel and spaced-apart, generally horizontally oriented top and bottom plates 705 and 706; parallel and spaced-apart, generally vertically oriented plates 707 and 708; and a generally vertically oriented rear plate 709. The receiver 702 has a proximal end 710 and a distal end 712. The bottom plate 706 defines a cutout 714 facing the proximal end 710. The receiver 702 can be formed from any suitable material, such as injection-molded plastic.

[0129] A container 702 defines a horizontally oriented cavity or channel 716. The cavity or channel 716 extends across the width of the container 702 and into the container 702 to a rear plate 709. A generally circular opening 720 is defined on a top plate 705 facing the rear plate 709. An opening 722 extends through the rear plate 709 adjacent to a plate 708 at its distal end 712. A pair of parallel, directly opposing, elongated, spaced grooves 724 are defined on each of the inner surfaces of plates 707 and 708. The grooves 724 face the cavity or channel 716. The top plate 705 defines a pair of adjacent and mutually extending recesses 746 and 748 at its proximal end 710. Recess 746 extends slightly further into the top plate 705 than recess 748.

[0130] Several holes extend through the top plate 705. Holes 760, 762, 764, 766, 768, and 770 extend through the top plate 705 into the cavity 716. A wax motor or linear actuator 80 is mounted on each of holes 760-770. Figure 24B Only one hole is shown. One end of rod 81 is connected to actuator 80, while the other rounded end of rod 81 rests against clamping valve 872. Rod 81 extends through top plate 705 to contact clamping valve 872.

[0131] The flushing connector 730 provides a fluid connection between a flushing fluid source, such as a water bottle 1500 and a container 800. The flushing connector 730 extends away from the bottom surface or bottom surface 706 and below it toward the proximal end 710 and adjacent to the plate 707. The flushing connector 730 has a generally rectangular body 732 with a proximal end 734 and a distal end 736. A pair of generally parallel arms 738 extend toward the proximal end 734 and define a groove 742 between them. Directly opposing grooves 740 are defined on the inner surface of each arm 738 facing the groove 742. Finger-like portions 744 are disposed in each arm 738 and extend into the groove 740.

[0132] B. Box Now for reference Figure 26 and 27 The details of box 800 are shown. Box 800 is generally rectangular in shape and includes a housing 822, which has three parts: an upper housing 824, an opposing lower housing 826, and a rubber sheet 1000 disposed between the upper housing 824 and the lower housing 826. Although the housing is shown as using three parts, it is contemplated that housing 822 could be formed as a single, integral part. The upper housing 824, the rubber sheet 1000, and the lower housing 826 mate together to form housing 822. A cavity 827 is defined within housing 822 between the upper housing 824 and the lower housing 826.

[0133] The upper housing 824 includes a planar top plate 828, a front plate 829, a back plate 830, and side plates 832 and 834. Plates 828, 829, 830, 832, and 834 extend perpendicularly away from the top plate 828. The upper housing 824 has a proximal end 835 and a distal end 836. A tapered portion 837 is defined at the distal end 836 on each of plates 832 and 834. During insertion of the cartridge 800, the tapered portion 837 guides the housing 822 into the receiving seat 702. The cartridge 800 can be formed from any suitable material, such as injection-molded plastic. In an embodiment, the cartridge 800 is formed from a transparent material.

[0134] like Figure 26 As shown in Figures 27 and 30A-30C, the flexible protrusion 838 is defined by a U-shaped slot 840 on the top plate 828. A protrusion 841 extends upward from the flexible protrusion 838, and a series of parallel ribs 842 extend upward from the flexible protrusion 838 and are positioned perpendicular to the longitudinal axis of the flexible protrusion 838. The flexible protrusion 838 is slightly displaced using manual pressure applied by the user. An inclined surface 844 slopes downward toward the front plate 829 adjacent to the flexible protrusion 838 in the top plate 828 and terminates approximately above the central U-shaped opening 846 of the front plate 829. The inclined surface 844 is transparent.

[0135] Another U-shaped opening 847 is disposed adjacent to plate 834 on the front plate 829. An additional U-shaped opening 848 is disposed adjacent to plate 835 on the front plate 829. A shallow recess 849 is defined between openings 846 and 848 on plate 829. Yet another U-shaped opening 852 is disposed adjacent to plate 834 on the rear plate 830.

[0136] refer to Figures 30A-30C Six clamping valves are defined on the top plate 828. The clamping valves are flexible and are pressed down by a device such as an electromagnet tube or a wax motor (not shown). A flushing supply clamping valve 860 is defined on the top plate 828 by a generally U-shaped slot 862. The flushing supply clamping valve 860 has downwardly extending fingers 864 facing the cavity 827.

[0137] The instrument flushing and irrigation clamping valve 866 is defined on the top plate 828 by a generally U-shaped slot 868. The instrument flushing and irrigation clamping valve 860 has downwardly extending fingers 870 facing into the cavity 827.

[0138] A suction bypass clamping valve 872 is defined on a top plate 828 via a generally U-shaped slot 874. The suction bypass clamping valve 872 has downwardly extending fingers 876 facing into the cavity 827. A tissue collection suction clamping valve 878 is defined on the top plate 828 via a generally U-shaped slot 880. The tissue collection suction clamping valve 878 has downwardly extending fingers 882 facing into the cavity 827.

[0139] Another tissue collection suction clamp valve 884 is defined on the top plate 828 via a generally U-shaped slot 886. The tissue collection suction clamp valve 884 has downwardly extending fingers 888 facing into the cavity 827. A tweezers flushing suction clamp valve 890 is defined on the top plate 828 via a generally U-shaped slot 892. The tweezers flushing suction clamp valve 890 has downwardly extending fingers 894 facing into the cavity 827.

[0140] Linear actuator 80 ( Figure 24B The clamping valve can be pressed down and opened. Figure 24B In the diagram, actuator 80 is shown connected to rod 81 in contact with clamping valve 872. Lowering rod 81 causes finger 876 to contact suction groove 1076. Suction groove 1076 is pressed between finger 876 and base plate 932, cutting off fluid flow through suction groove 1076. Raising rod 81 causes finger 876 to rise from suction groove 1076, allowing fluid to flow through suction groove 1076.

[0141] The curved plate portion 896 of the top plate 828 defines a groove 897. The curved plate portion 896 originates from the rear plate 830 and extends toward the dome 898. The semi-circular dome 898 is defined in the top plate 828. A semi-circular groove 900 is defined in the top plate 828 between the dome 898 and the curved plate portion 896.

[0142] A pair of curved and spaced-apart plates 902 and 903 extend from groove 900 toward proximal end 835. Plates 902 and 903 are generally parallel to each other and extend vertically away from top plate 828, defining channel 904. Another pair of spaced-apart plates 905 and 906 are disposed between fingers 864 and 870, respectively. Plate 905 extends vertically from top plate 828 and connects with the proximal end of plate 903 to form channel 908. Plate 906 extends vertically from top plate 828 and curves to its end at inclined surface 844, forming channel 910 together with plate 902. Plate 911 is disposed between plates 902 and 906 and adjacent to inclined surface 844. Plate 911 extends vertically away from top plate 828. Plates 902, 911, and 906 define a pair of outlets 912 adjacent to inclined surface 844.

[0143] Another pair of curved and spaced-apart plates 914 and 916 extend from groove 900 toward finger portion 870 and terminate at plate 902. Plates 914 and 916 are generally parallel to each other and extend perpendicularly away from top plate 828, defining channel 917. Generally parallel and spaced-apart plates 918 and 919 extend adjacent to plate 834, generally between proximal end 835 and distal end 836. Plates 918 and 919 are generally parallel to each other and extend perpendicularly away from top plate 828, defining channel 920. Generally curved and spaced-apart plates 926 and 927 form a V-shape and extend generally between plates 919 and 917. Plates 926 and 927 extend perpendicularly away from top plate 828, defining channel 928. Channel 928 merges with channel 920. Branch 922 deviates at an angle from channel 920 in the direction toward finger portion 888.

[0144] Now for reference Figure 26 27 and 28A-28C, the lower housing 826 includes a substrate 930 having a top surface 932, a bottom surface 934, and side surfaces 937 and 938. The lower housing 826 has a proximal end 935 and a distal end 936. A post 940 extends vertically from the top surface 932 at the corner of the side surface 937 and the distal end 936. A wedge-shaped post 942 extends vertically from the top surface 932 at the corner of the side surface 938 and the distal end 936. A connector 944 extends through the post 942. The connector 944 has a tapered, outwardly facing distal end 945, which includes an annular groove 946 sized to receive an O-ring 947.

[0145] Another wedge-shaped column 948 extends vertically from the top surface 932 at the corner of the side 938 and the proximal end 935. A connector 949 extends through the column 948. The connector 949 has a tapered, outwardly facing proximal end 950, sized to receive the suction line 50. Figure 1A Another wedge-shaped column 952 extends vertically from the top surface 932 at the corners of the side surface 937 and the proximal end 935. A connector 954 extends through the column 952. The connector 954 has an outwardly facing distal end 955, which is sized to receive the flushing line 51. Figure 1A A series of cones or barbs 956 surround the connector 954 to hold the flush line 51 to the connector 954. The wider base of the barbs 956 faces the front plate 935.

[0146] A connector 958 extends vertically from the front panel surface 935. A groove 960 is defined on the top surface 932, immediately adjacent to the distal side of the connector 958. A generally square stop 962 extends vertically from the top surface 932 adjacent to the groove 960 at its proximal end 935. An inclined plate 964 slopes upward from the top surface 932 at a position adjacent to the column 952 and terminates at a position adjacent to the stop 962. The inclined plate 964 defines a groove 990 on the bottom surface 934. A groove 963 is defined on the bottom surface 934 below the stop 962.

[0147] An inclined plate 967 slopes upward from the top surface 932, begins near the center of the lower housing 826, and terminates at a dome 968. The dome 968 extends distally away from the top surface 932. A groove 969 is defined on the bottom surface 934, below the inclined plate 967 and the dome 968. A channel 966 is defined on the top surface 932, begins at the column 952, extends upward along the inclined plate 967, passes around the outer circumference of the dome 968, extends downward along the inclined plate 967, and terminates at a aperture 970. The aperture 970 extends through the plate 930.

[0148] A pair of parallel grooves 965 are defined on an inclined plate 964 and extend along the width of the inclined plate 964. Another groove 972 is defined on a top surface 932 and extends between grooves 966 and 965. Holes 974 and 975 are defined on a plate 930 and extend through the plate 930. Groove 976 is defined on the top surface 932 and extends between pillars 942 and 948. Groove 976 is coaxial with and extends along with joints 949 and 945. Groove 978 is defined on the top surface 932 and extends between a recess 960 and a hole 974. Groove 980 is defined on the top surface 932 and extends between groove 976 and a hole 974. Groove 981 is defined on the top surface 932 and extends between groove 976 and a hole 975.

[0149] A U-shaped semicircular guide rail 982 extends perpendicularly below the bottom surface 934 towards the proximal end 935 and adjacent to the side surface 938, away from the bottom surface 934. The guide rail 982 has opposing ends 983 and an inwardly facing lip 984. The guide rail 982 and the bottom surface 934 define a groove 985. A circular protrusion 986 extends from the bottom surface 934 into the groove 985 and surrounds the aperture 975. A groove 988 is defined on the bottom surface 934 between the guide rail 982 and the side surface 937 and surrounds the aperture 970.

[0150] refer to Figure 26 Figures 27 and 29A-29C show details of the flexible sheet 1000. The flexible sheet 1000 is sandwiched between the upper housing 824 and the lower housing 826. The flexible sheet 1000 can be formed from any suitable flexible material such as rubber or silicone rubber.

[0151] The flexible sheet 1000 includes a substrate 1030 having a top surface 1032, a bottom surface 1034, and side surfaces 1037 and 1038. The flexible sheet 1000 has a proximal end 1035 and a distal end 1036. A tilted portion 1042 tilts distally away from the top surface 1032 at the corner of the side surface 1038 and the distal end 1036. The tilted portion 1042 is located above a pillar 942. Another tilted portion 1044 tilts distally away from the top surface 1032 at the corner of the side surface 1038 and the proximal end 1035. The tilted portion 1044 is located above a pillar 948. Yet another tilted portion 1048 tilts distally away from the top surface 1032 at the corner of the side surface 1037 and the proximal end 1035. The tilted portion 1048 is located above a pillar 952.

[0152] The inclined plate 1067 slopes upward from the top surface 1032, starting near the center of the flexible sheet 1000 and ending at the dome 1068. The dome 1068 extends distally away from the top surface 1032. A groove 1069 is defined on the bottom surface 1034 below the inclined plate 1067 and the dome 1068.

[0153] Plates 1051, 1052, 1053, and 1050 extend vertically away from the top surface 1032 toward the proximal end 1035 and define an instrument flushing chamber 1050. Plates 1053 and 1052 slope downward from plate 1054 to plate 1051. A U-shaped port 1056 is defined in plate 1051.

[0154] The irrigation channel 1066 is defined in the plate 1030 and opens toward the bottom surface 934. The irrigation channel 1066 extends from the end 1069 in the inclined plate 1048, along the inclined plate 1067, around the outer circumference of the dome 1068, along the inclined plate 1067 and terminates at the end 1070.

[0155] A set of parallel irrigation tubes 1065 are defined in plate 1030 and open toward bottom surface 1034. Irrigation tubes 1065 extend along the width of inclined plate 1064 and terminate within instrument flushing chamber 1050. Another irrigation tube 1072 is defined in plate 1030 and open toward bottom surface 1034. Irrigation tube 1072 extends between irrigation tube 1065 and irrigation channel 1076. Irrigation tubes 1065, 1066, and 1072 are in fluid communication with each other.

[0156] A suction tube 1076 is defined in plate 1030 and opens toward bottom surface 1034. Suction tube 1076 extends between inclined portions 1044 and 1046. Suction tube 1078 is defined in plate 1030 and opens toward bottom surface 1034. Suction tube 1078 extends between junction 1082 and instrument flushing chamber 1050. Suction tube 1080 is defined in plate 1030 and opens toward bottom surface 1034. Suction tube 1080 extends between suction tube 1076 and junction 1082. Instrument flushing chamber 1050, suction tubes 1076, 1078, and 1080 are in fluid communication with each other. Suction tube 1081 extends between suction tube 1076 and junction 1083. Suction tubes 1076 and 1081 are in fluid communication with each other.

[0157] A generally square stop portion 1086 extends vertically from the top surface 1032 to the proximal end 1035 adjacent to the instrument flushing chamber 1050. A recess 1088 is defined below the stop portion 1086 in the bottom surface 1034. A cover 1090 is attached to a flexible arm portion 1092. The arm portion 1092 is attached to the proximal end 1035 adjacent to an inclined plate 1064.

[0158] Upper housing 824 and lower housing 826 are fitted together to form housing 822 of box 800 together with rubber sheet 1000 between them. Housings 824 and 826 are held together by press-fitting or snap-fitting. In one embodiment, housings 824 and 826 are held together by adhesive. At the mating position, rubber sheet 1000 is sandwiched between upper housing 824 and lower housing 825. Pressure between upper housing 824 and lower housing 826 creates a fluid path seal between rubber sheet 1000 and lower housing 826.

[0159] refer to Figure 31 and 32The image shows a tissue trap 1198. The tissue trap 1198 includes a specimen container 1400 housing a tissue filter 1200. The tissue filter 1200 is generally cylindrical in shape. Other shapes, such as circular, oval, or square, can be used. The tissue filter 1200 can be formed from any suitable material, such as a low-hardness plastic or thermoplastic elastomer. The tissue filter 1200 can be formed from a transparent material, allowing the contents to be seen by the user.

[0160] The tissue filter 1200 is defined by a top plate 1202. The top plate 1202 has a bottom surface 1203 and a top surface 1204. A pore 1250 is defined in the top plate 1202 and surrounded by a groove 1252. An opening 1254 is defined in the top plate 1202. A generally annular side plate 1206 extends perpendicularly away from the outer periphery of the top plate 1202 and the bottom surface 1203. Flat portions 1256 are provided on opposite sides of the annular side plate 1206. Flexible tips or protrusions 1258 extend outward from each flat portion 1256 and are spaced apart from each flat portion 1256 by a slit 1260.

[0161] A pair of juxtaposed elongated hollow tubes 1210 and 1216 extend away from the bottom surface 1203 in a distal direction. Tube 1210 has a proximal end 1211 and a distal end 1212. Tube 1216 has a proximal end 1217 and a distal end 1218. The proximal ends 1211 and 1217 are connected to the bottom surface 1203. In one embodiment, tubes 1210 and 1216 may contain a preservative solution 389 (… Figure 22D For example, formalin or other suitable preservatives. In another embodiment, the preservative is omitted. Preservative 389 is sealed within tubes 1210 and 1216 by foil or plastic seals 1236.

[0162] Another elongated tube 1222 extends distally away from the bottom surface 1203. The tube 1222 has a proximal end 1224 and a distal end 1226. The proximal end 1224 is connected to the bottom surface 1203. A base plate 1227 is disposed at the distal end 1226 of the tube 1222. An elongated opening 1228 is defined on the tube 1222 extending between the proximal end 1224 and the distal end 1226. The tube 1222 has a cavity 1230. The cavity 1230 is continuous with or extends together with the opening 1254. A sieve 1234 extends across the diameter of the tube 1222 toward the distal end 1226. A tissue sample 398 is shown as being passed through... Figure 31 The sieve 1234 in the middle captures.

[0163] An elongated conduit 1240 extends distally away from the bottom surface 1203. The conduit 1240 has a proximal end 1242 (not shown) and a distal end 1244. The proximal end 1242 is connected to the bottom surface 1203. The distal end 1244 extends slightly beyond the ends of tubes 1210 and 1216. An orifice 1246 is defined on the conduit 1240 and extends between the distal end 1244 and the orifice 1250.

[0164] The specimen container or jar 1400 has a generally square shape with rounded corners. The specimen container 1400 has an outer plate 1402 and a bottom plate 1404. On opposite sides of the specimen container 1400, two spaced-apart flat gripping portions 1406 are provided on the outer plate 1402. A chamber 1408 is defined within the specimen container 1400. The specimen container 1400 has a top end 1410 and a bottom end 1412. The specimen container 1400 is formed of a transparent material, allowing the contents of the chamber 1408 to be seen by the user.

[0165] An annular flange 1416 extends outward from the outer periphery of plate 1402 at its tip 1410. The flange 1416 has an inner surface 1418 and an outer surface 1420. An annular thread 1422 is defined on the outer surface 1420. Two opposing flat portions 1424 are provided on the inner surface 1418. A step 1426 extends from the inner surface 1418 around the entire circumference of the surface. The step 1426 slopes downward from the flange 1416 toward plate 1402.

[0166] Edge 1430 extends downward from the outer periphery away from the base plate 1404. Edge 1430 has an inclined or angled edge 1432 that slopes inward from the outer plate 1402. Protrusion 1436 extends distally away from the base plate 1404 and is adjacent to one side of edge 1430. Tip 1437 extends upward away from the base plate 1404 into the compartment 1408. Window 1438 is provided on the outer plate 1402. Window 1438 allows the user to see the contents of compartment 1408.

[0167] The circular cap 1450 has a top plate 1452 and an annular side plate 1454 extending vertically downward from the top plate 1452. Knurled ribs 1456 are provided on the outer surface of the side plate 1454 to allow the user to better grip the cap 1450. An edge 1458 extends vertically upward away from the top plate 1452. An annular thread 1460 is defined on the inner surface of the side plate 1454. An annular flange 1462 extends vertically away from the top plate 1452 in a manner parallel to and slightly spaced from the side plate 1454. A pair of opposing notches 1464 are defined on the flange 1462. A groove 1466 is defined between the flange 1462 and the side plate 1454.

[0168] By rotating the lid 1450 relative to the specimen container 1400 to engage threads 1422 and 1460, the lid 1450 is attached to the top 1410 of the specimen container 1400. The lid 1450 can also be attached to the bottom 1412 of the specimen container 1400. The edge 1458 is positioned by the user adjacent to and pressed against the edge 1430. The angled edge 1432 guides the edge 1458 into frictional contact with the edge 1430, thus holding the lid 1450 to the bottom of the specimen container 1400.

[0169] The identification device 376 is attached to the outer panel 1402. The identification device 376 has the same structure as the aforementioned identification device and performs the same function.

[0170] The tissue sample 398 can be a variety of tissue specimens. For example, the tissue sample 398 can be a biopsy sample from a body part or a polyp from the colon. The tissue filter 1200 will slide into the compartment 1408 until the tip or protrusion 1258 engages the flat portion 1424 above the step 1426. At this point, the step 1426 provides resistance against further insertion of the tissue filter 1200 into the compartment 1408.

[0171] Tissue trap 1198 is removably engaged with cassette 800. Trapper 1190 is inserted by horizontally pushing tissue filter 1200 and specimen container 1400 into cavity 985, causing flange 1416 and thread 1422 to slide into L-shaped guide rail 982 and be secured by lip 984. Trapper 1198 hangs below cassette 800. Trapper 1198 is removed from cassette 800 by horizontally pulling tissue filter 1200 and specimen container 1400 away from cassette 800. Multiple tissue samples can be collected using multiple tissue traps 1200.

[0172] The user places the cap 1450 on the tissue filter 1200. As the cap 1450 is rotated relative to the specimen container 1400, the inner surface of the cap top plate 1452 contacts the top plate 1204 of the tissue filter 1200. Threads 1422 and 1460 cause the cap 1450 to rotate, thereby forcing the tissue filter 1200 downward into the compartment 1408. Step 1426 causes the tip or protrusion 1258 to bend inward and slide along the plate 1406 of the specimen container until the bottom edge of the plate 1206 abuts against the step 1426. As the tissue filter 1200 moves downward into the compartment 1408, the tip 1437, fitted to the bottom plate 1404, pierces the foil or plastic seal 1236, releasing the preservative solution 389. Figure 17 ), to cover tissue sample 398.

[0173] Now for reference Figure 33 and 34A water bottle 1500 is shown. The water bottle 1500 is shown in a generally rectangular shape. Other shapes, such as circular or elliptical, may be used. The water bottle 1500 is defined by six outer plates, including opposing parallel and spaced-apart generally vertically oriented plates 1502 and 1504; opposing parallel and spaced-apart generally vertically oriented plates 1506 and 1508; and a generally horizontally oriented bottom plate 1510. The top plate 1511 slopes upwards away from the side plates 1502, 1504, 1506, and 1508. The side plates 1502, 1504, 1506, and 1508 are perpendicular to the bottom plate 1510. The water bottle 1500 has a top end 1514 and a bottom end 1512.

[0174] Plates 1502, 1504, 1506, 1508, 1510, and 1511 define a reservoir 1520 within the water bottle 1500. The water bottle 1500 may be formed from any suitable material, such as blow-molded plastic. In one embodiment, the water bottle 1500 is formed from a transparent material, allowing the contents or level of the reservoir 1520 to be seen by the user.

[0175] The water bottle 1500 has a neck 1524 extending away from the top wall 1511. An annular flange 1526 surrounds the neck 1524. A thread 1528 is defined at the top end 1514 on the outer surface of the neck 1524. An opening 1530 allows access to the reservoir 1520. An elongated tube 1540 has ends 1542 and 1544. A round cap 1560 has a thread 1562, an annular flange 1564 at one end, and a neck 1566 with a smaller diameter. Holes 1570 and 1572 are defined in the flange 1564.

[0176] The water bottle 1500 is filled with flushing fluid. The water bottle 1500 is assembled by passing the end of the tube 1542 through the orifice 1570 of the cap 1560 and the end of the tube 1544 through the opening 1530 into the bottle 1500. The orifice 1572 allows the air pressure inside and outside the bottle 1500 to be balanced, so that a vacuum is not formed inside the bottle 1500.

[0177] The water bottle 1500 is removably engaged with the container 702. The water bottle 1500 is inserted by the user manually sliding it horizontally towards the slot 742 and into the slot 742, causing the arm 740 to bend and clamp the neck 1566. The water bottle 1500 hangs below the box 800, supported by the flange 1564. The fingers 744 hold the water bottle 1500 and prevent it from slipping out of the slot 742. The water bottle 1500 is removed from the box 800 by the user manually pulling it horizontally away from the box 800, causing the arm 740 to bend and allowing the neck 1566 to slide past the fingers 744.

[0178] C. Operation refer to Figure 1A -C, 15B and 23-34, movable unit 30 ( Figure 1A A cartridge 800 is prepared for use by a user to insert into the complementary reservoir 702 associated with the canister 38 of the manifold assembly 700, whereby waste aspirated from the surgical site is collected in the canister 38. This step is performed by aligning the tapered portion 837 of the cartridge 800 with the groove 724 of the reservoir 702 and sliding the cartridge 800 into the channel or cavity 716. Sides 832 and 834 slide along the groove 724 until the back plate 830 contacts the back plate 709 of the reservoir 702. In this position, the connector 944 is positioned in the aspiration cannula 59. Figure 15B It is in fluid communication with the cavity or channel 716. The rib 842 of the flexible protrusion 838 deflects below the front edge 749 of the top plate 705. The flexible protrusion 842 holds the box 800 in the cavity or channel 716.

[0179] A peristaltic pump roller 74 is mounted through opening 720 to contact the irrigation channel 1076. The irrigation channel 1076 is compressed between the peristaltic pump roller 74 and groove 966, so that the rotation of the roller 74 forces irrigation fluid through the irrigation channel 1076. The roller 74 and pump motor 71 are mounted at an angle offset from a vertical axis defined perpendicular to the top plate 705, allowing the roller 74 to rotate freely without contacting the dome 898.

[0180] When the box 800 is placed in the housing 702, the RFID reader 194 identifies the identification device 376, such as an RFID tag, and sends a signal to the controller 192 to allow the movable unit 30 to operate.

[0181] The water bottle 1500 is attached to the container 702 by bending its arm 740 within a horizontal insertion slot 742 to hold the neck 1566. The water bottle 1500 is suspended below the box 800 supported by a flange 1564. The fingers 744 hold the water bottle 1500 and prevent it from slipping out of the slot 742. In this position, the annular flange orifice 1570 is pressed against the orifice 970 and thus in fluid communication with the irrigation channel 1066.

[0182] By horizontally inserting the tissue filter 1200 and specimen container 1400 into the cavity 985, the flange 1416 and thread 1422 slide into the L-shaped guide rail 982 and are secured by the lip 984, the tissue filter 1200 and specimen container 1400 are attached to the box 800. The tissue filter 1200 and specimen container 1400 are suspended below the box 800.

[0183] The unit is completed for use by attaching the aspiration line 50 to the connector 949 and the irrigation line 51 to the connector 954, thereby engaging the applicator 52, such as a colonoscope, to the movable unit 30. The cap 1090 is initially placed on the second aspiration connector 958 and seals the second aspiration connector 958.

[0184] The movable unit 30 is actuated by actuating the suction pump 58 and the peristaltic pump 70. The operator uses the control panel 196 to select the operating mode. When the operator selects the bypass mode, the clamping valve actuator 80 closes the clamping valves 884 and 878, respectively, while the clamping valve 872 remains open. Actuation of the suction pump 58 causes a waste stream to be drawn from the surgical site into the applicator 52 along the suction fluid communication path 184, and into the connector 949 through the suction line 50. This waste stream includes liquid and solid waste applied to the applicator 52 and air adjacent to the applicator 52. After passing through the connector 949, the waste stream flows through the groove 976 and the suction tube 1076 and into the conduit 59 through the connector 944. After passing through the conduit 59, the waste fluid stream flows into the associated tank 36 or 38. This operating mode is called the bypass mode because the suction fluid communication path 184 bypasses the tissue filter 1200.

[0185] The liquid and solid components of the waste stream entering tank 36 or 38 are separated into liquid streams and retained within tank 36 and 38 for final treatment.

[0186] The actuation of the peristaltic pump 70 causes the irrigation fluid to be pumped from the water bottle 1500 through the pipe 1540, through the orifice 970, the groove 966 and the irrigation channel 1076, and through the connector 954 and the irrigation line 51 into the applicator 52 for application to the surgical site.

[0187] The user can choose to use cartridge 800 to collect tissue samples, such as polyps. Cartridge 800 is selected for a particular operating mode by moving certain clamping valves using actuator 80. The operator selects this operating mode using control panel 196. When the operator selects the tissue collection mode, clamping valves 872 and 890 are closed, and clamping valves 884 and 878 are opened.

[0188] The movable unit 30 is re-actuated by the re-actuation aspiration pump 58 and the peristaltic pump 70. When the system is in this operating mode, the waste stream, along with the contained tissue sample, is aspirated from the surgical site into the applicator 52 along the aspiration fluid communication path 184, through the aspiration line 50, and into the connector 949. This waste stream includes liquid and solid waste aspirated onto the applicator 52, as well as sample tissue 398 and air adjacent to the applicator 52.

[0189] After passing through connector 949, the waste stream flows through groove 976 and suction pipe 1076, groove 980 and suction pipe 1080, through pore 974, cavity 1230, screen 1234, aperture 1246, pore 1250, and pore 975 into groove 981 and suction pipe 1081, groove 976 and suction pipe 1076, and then through connector 944 into conduit 59. After passing through conduit 59, the waste stream flows into the associated tank 36 or 38. Tissue sample 398 is captured by screen 1234 within tissue filter 1200. This operating mode is called tissue collection mode because the suction fluid communication path 184 passes through tissue filter 1200. Note that to collect samples in tissue collection mode, it is not necessary to disconnect or reconnect suction line 50.

[0190] The user can choose to use cartridge 800 and tissue capture device 1198 to collect tissue samples extracted by the instrument. Cartridge 800 is placed in the extracted tissue capture mode by moving the selected clamping valve using actuator 80. The operator uses control panel 196 to place the cartridge in this mode. In the extracted tissue capture mode, clamping valves 872 and 878 are closed, and clamping valves 884 and 890 are open. Cap 1090 is removed from connector 958.

[0191] When the system is in the extracted tissue capture mode, waste streams are drawn from connector 958 into instrument flushing chamber 1050 via aspiration fluid communication path 184. The user can place the tissue sample 398 held by the instrument (not shown) into instrument flushing chamber 1050 through connector 958. The tissue sample within instrument flushing chamber 1050 is visible through transparent inclined surface 844.

[0192] The operator uses control panel 196 to regulate the supply of irrigation fluid. Irrigation fluid is supplied to instrument flushing chamber 1050 by opening clamp valve 866 using one of the actuators 80. Pressurized irrigation fluid flows from irrigation channel 1076 through irrigation tubes 1072 and 1065 into instrument flushing chamber 1050, allowing the flushing of tissue samples placed within instrument flushing chamber 1050.

[0193] From connector 949, tissue samples and waste flow through groove 978 and suction tube 1078, through pore 974, cavity 1230, screen 1234, aperture 1246, pore 1250, and pore 975 into groove 981 and suction tube 1081, groove 976 and suction tube 1076, and then through connector 944 into conduit 59. After passing through conduit 59, waste flows into the associated tank 36 or 38. Tissue sample 398 is captured by screen 1234 within tissue filter 1200. This operating mode is referred to as forceps sample collection mode because the aspiration fluid communication path 184 passes through instrument flushing chamber 1050 and tissue filter 1200.

[0194] To remove the tissue trap 1198, the operator first uses the control panel 196 to return the operating mode of the movable unit 30 to the bypass mode. This removes the aspiration communication path from the tissue trap 1198. By horizontally pulling the tissue filter 1200 and specimen container 1400 away from the cassette 800, causing the specimen container 1400 to slide out along the guide rail 982, the tissue filter 1200 and specimen container 1400 are removed from the cassette 800. By horizontally pushing the tissue filter 1200 and specimen container 1400 into the cavity 985 along the guide rail 982, another tissue filter 1200 and specimen container 1400 are inserted for collecting another tissue sample. The tissue trap 1198 is then inserted into and removed from the cassette 800 as a single unit.

[0195] The suction pump 58 does not need to be turned off during the removal of a tissue trap 1198 from the cartridge 800 and the attachment of a new trap 1198. In other words, the new tissue trap 1198 can be attached to the cartridge 800 without interrupting the suction force applied to the suction applicator.

[0196] In order to collect another tissue sample, the operator uses the control panel 196 to return the operation mode of the movable unit 30 to the tissue sample collection mode.

[0197] The user places the cap 1450 onto the tissue filter 1200. As the cap 1450 is rotated relative to the specimen container 1400, the inner surface of the cap top plate 1452 contacts the top plate 1204 of the tissue filter 1200. Threads 1422 and 1460 cause the cap 1450 to rotate, thereby forcing the tissue filter 1200 downward into the compartment 1408. Wall 1462 causes the tip or protrusion 1258 to bend inward and slide along the plate 1406 of the specimen container until the bottom edge of the plate 1206 abuts against the step 1426. As the tissue filter 1200 moves downward into the compartment 1408, the tip 1437, fitted to the bottom plate 1404, pierces the foil or plastic seal 1236, releasing the preservative solution 389. Figure 17 ), to cover tissue sample 398.

[0198] Once the medical / surgical procedure is complete and the movable unit 30 is no longer needed, the suction line 50 and irrigation line 51 can be disconnected from connectors 949 and 958, respectively. The flexible protrusion 838 is manually pressed down, and the cassette 800 is manually removed by pulling it away from the container 702. The cassette 800 is disposed of as medical waste.

[0199] After use, the movable unit 30 is engaged with the storage container (not shown in the figure and not part of the invention). Waste material in tanks 36 or 38 flows through the storage container into the treatment facility.

[0200] It should also be recognized that in this form of the invention, the plastic forming the tissue filter 1200 and the specimen container 1400 is at least partially transparent. This provides medical personnel with a quick means of verifying that a tissue sample has been collected. Additionally, the box 800 is made of a material that is at least partially transparent. This provides medical personnel with a quick means of verifying that the box has not been previously used and does not contain previously collected waste.

[0201] This invention allows the aspiration fluid communication path to be selectively routed to and out of the tissue sample container.

[0202] V. Fourth Embodiment A. Seat Figure 35-4 2 indicates that it can be Figure 1A An alternative cartridge 1700 is used in conjunction with an alternative manifold receiver 1699 as part of the collection system 30. The manifold receiver 1699, sometimes referred to as a manifold receiver, is disclosed in detail in U.S. Patent No. 7,615,037, which is incorporated herein by reference.

[0203] Special Reference Figure 35 and 36 The manifold container 1699 includes three main stationary components. A housing 1602 is located near the proximal end of a receiver box 1700. A receiver adapter 1604 holds the manifold container housing 1602 to the lid 40 of the associated canister. Figure 1A The adapter 1604 also includes a conduit 59 serving as a flow path from the manifold housing 1602 to the associated tank 36. A locking ring 1606 is attached to the distal front end of the manifold housing 1602. The locking ring 1606 is formed with geometric features to ensure that the housing 1700 is properly aligned when it is installed into the reservoir 1699.

[0204] The housing 1602 is formed to define coaxial channels or apertures 1610 and 1612 extending through the housing 1602. At the distal end, a spring-loaded door 1634 is mounted to the housing 1602, which can be selectively opened by insertion of the housing 1700 and closed by removal of the housing 1700.

[0205] The conduit 59, providing a fluid communication path from the housing 1602 to the associated tank 36, is elbow-shaped with a bend between 80 and 90 degrees. The distal end of the conduit 59 extends into the housing 1700.

[0206] The locking ring 1606 is generally annular and has a centrally located through opening 1615. A plurality of apertures 1616 extend longitudinally through the ring. The apertures 1616 receive fasteners for retaining the locking ring 1606 to the manifold housing 1602. The locking ring 1606 is further formed to define a pair of slots 1618 (in Figure 35 The slots 1618 and 1620 are located behind box 1700. Slots 1618 and 1620 are continuous with the through opening 1615 and extend radially outward from the opening 1615 to the proximal end of the locking ring 1606. Slots 1618 and 1620 are opposite each other in the diametrical direction and have different arcuate profiles. The arc facing slot 1618 is larger than the arc facing slot 1620.

[0207] Both grooves 1618 and 1620 extend the length of the locking ring 1606. At the proximal end, the locking ring 1606 is further formed with a pair of grooves 1622. Each groove is arcuate in shape and formed within the locking ring. Each groove 1622 is also continuous with one of the grooves 1618 or 1620. The grooves 1622 are generally opposite each other in the diametrical direction. Since the proximal end of the locking ring 1606 abuts against the distally facing surface of the housing 1602, the grooves 1622 serve as channels through which the protrusion integral with the box 1700 passes, as will be described in more detail below.

[0208] Valve disc 1632 typically covers the opening leading to the conduit 59. When the housing 1700 is not inserted, the spring-loaded door 1634 extends over the distal end opening into the aperture 1610 of the housing 1602.

[0209] The manifold housing 1699 is configured such that when the valve disc 1632 is in a specific rotational position within the housing 1602, the valve disc 1632 covers the opening leading to the conduit 59. The valve disc 1632 is rotatable to align the orifice 1638 with the conduit 59.

[0210] B. Box Referring also to Figures 37-39, the main components of box 1700 are shown. Box 1700 includes a housing 1701, which has a proximal outer shell 1750 with a cover 1702 attached to its distal side. The outer shell 1750 is open at one end, and the cover 1702 covers the open end. The outer shell 1750 and the cover 1702 may be formed of a suitable material such as injection-molded plastic. Inside box 1700 and housing 1701 is a cavity or void space 1704 (…). Figure 38B ).

[0211] refer to Figure 41A-E, the outer shell 1750 has a generally cylindrical shape. The outer shell 1750 is formed with a rounded proximal end or base 1752, and a tubular sidewall 1754 extending upward from the proximal end or base 1752. A lip 1756 extends from the outer periphery around the open tip of the sidewall 1754. The lip 1756 protrudes radially outward. Two finger-like portions 1761 and 1762 and a protrusion 1763 extend upward distally from the top of the sidewall 1754. Each finger-like portion 1761 and 1762 has an arcuate cross-sectional profile. Finger-like portion 1761 faces a relatively larger arc. Finger-like portion 1762 faces a relatively shorter arc.

[0212] An opening 1770 is formed in the housing base 1752. The opening is sized to receive a protrusion integral with the valve disc 1632. The housing is formed such that the opening 1770 is centered along an axis eccentric to the longitudinal axis of the housing 1750. A circular lip 1772 extends downward around the circular opening 1770 from the housing base 1752. The lip 1772 is radially spaced apart by an annular cross-section defining the outer periphery of the opening 1770 away from the housing base 1752.

[0213] A drip stop 1774 is installed within the manifold opening 1770. The drip stop 1774 is formed of a compressible, elastic material such as polyisoprene rubber. The drip stop 1774 has a pair of lips 1775 with a slot or groove 1790 between them. The groove 1790 allows the conduit 59 to slide through the drip stop 1774 into the cavity 1704, which forms part of the suction fluid communication path. When the cartridge 1700 is removed from the receiving seat 1699, the drip stop 1774 prevents any material from flowing out of the opening 1770.

[0214] Figure 40A -E shows details of the lid 1702. The lid 1702 is formed from a single piece of polypropylene or similar plastic. The lid 1702 has ends 1705 and 1706 and a cylindrical tubular skirt 1707. The lid 1702 is sized to allow the housing 1701 to be placed within and rotated within the receiver 1699. At the proximal end 1705 of the skirt 1707, two protrusions 1708 and 1709 project radially outward. Protrusions 1708 and 1709 are opposite each other in the diametrical direction. These protrusions face different arcs. Protrusion 1708 faces a relatively larger arc; this protrusion is designed to slide into the manifold receiver lock ring groove 1618. Protrusion 1709 faces a relatively shorter arc; this protrusion is designed to slide into the manifold receiver lock ring groove 1620.

[0215] The skirt 1707 of the lid is formed with an inwardly tapered edge 1710 at its end 1705. Adjacent to the edge 1710, the skirt 1707 has an outwardly extending step 1712 extending circumferentially around the interior of the skirt. The lid 1702 is sized such that the inner diameter of the skirt 1707 on the step 1712 is approximately 0.5 mm smaller than the outer diameter of the outer shell lip 1756. When the box 1700 is assembled, the outer shell 1750 is inserted into the lid 1702 such that the lip 1756 is compressed and abutted against the step 1712. The compression of the inner surface of the skirt 1707 around the lip 1756 substantially eliminates the loss of suction force between the lid and the skirt.

[0216] Numerous ribs extend inward from the inner surface of the skirt 1707 and are positioned on the step 1712. There are two pairs of adjacent ribs 1713 and another pair of adjacent ribs 1714. The ribs 1713 are spaced apart in an arcuate manner by a sufficient distance to allow the outer casing fingers 1761 to slide between them. The ribs 1714 are spaced apart by a sufficient distance to allow the protrusions 1763, rather than the fingers 1761, to slide between them. Thus, the outer casing fingers 1761 and protrusions 1763, and the rib pairs 1713 and 1714 facilitate alignment of the outer casing 1750 and the lid 1702 when assembled together.

[0217] A semi-barrel 1716 extends distally from the lower half of the skirt 1707, and a rectangular shell or box 1718 extends distally from the upper half of the skirt 1707. A semi-circular surface 1719 extends at the top of the skirt 1707, while another semi-circular surface 1720 extends at the top of the barrel 1716. Surface 1720 is formed with a centrally located aperture 1721 and a connector 1734 positioned towards the bottom of surface 1720. Connector 1734 has a through aperture 1722 in fluid communication with cavity 1704. Planar wall 1724 (in Figure 38B The best view (in the middle) extends between surface 1719 and surface 1720. Circular aperture 1725 ( Figure 38B It extends adjacent to surface 1720 through wall 1724.

[0218] A housing or enclosure 1718 defines a rectangular sleeve 1726 that defines an end-closed aperture 1727. The base of the sleeve 1726 is defined by a wall 1724. An opening 1729 is formed on the surface of an end cap 1706, defining the aperture of the sleeve 1726 as it extends inward from the cap. An inlet connector 1734 extends from the top of the housing 1718. The aperture 1728 of the connector 1734 is in fluid communication with the aperture 1727. In particular, the aperture 1728 opens to the inner surface of the sleeve 1726 opposite to the surface of the wall 1724. A semi-circular edge 1730 extends radially outward from the housing 1718. The edge 1730 is coplanar with and continuous with the flat surface of the end cap 1706.

[0219] The dimensions of connectors 1732 and 1734 are set to receive suction line 50.

[0220] A roughly U-shaped semi-body flange 1736 extends away from the end of the barrel 1716. A column 1738 extends vertically away from the top of the box 1718 and is slightly spaced from the edge 1730 and the joint 1734.

[0221] refer to Figure 37A and 37B A removable cover 1740 is provided for connectors 1732 and 1734. A removable cover 1741 is provided for covering the opening 1729 of sleeve 1726. Cover 1741 has a handle 1742 that can be gripped by a user and a portion that is installed into sleeve 1726. Each connector cover 1740 and cover 1741 is integrally attached to cover 1702 by a fastener 1744 having multiple arms 1746. The arms 1746 are anchored to post 1738.

[0222] Box 1700 includes tongue valve unit 1800, now regarding Figure 38B 38C and 38D are described. The tongue valve unit 1800 is formed from a single piece of a compressible, flexible material such as polyisoprene or other elastic material. The tongue valve unit 1800 has a disc-shaped hub 1802. The hub 1802 is formed with a central through hole 1804.

[0223] The tongue valve unit 1800 is mounted to the surface 1720 of the cover 1702. The post 1806 is inserted through the through hole 1804 into the aperture 1721 of the surface 1720. The post 1806 is heat-fused to the surface 1720, thereby holding the tongue valve unit 1800 to the cover 1702.

[0224] The hub 1802 of the tongue-shaped unit also has a plurality of annular ribs 1810 and 1812. A rib 1810 extends outward from opposite distal and proximal surfaces of the hub 1802. A rib 1812 also extends outward from each of these opposite surfaces of the hub 1802. Ribs 1810 are positioned near the through-hole 1804 of the hub. Ribs 1812 surround rib 1810. Each rib 1810 and 1812 has an inwardly inclined cross-sectional profile. Thus, each rib 1810 and 1812 extends outward from the surface of the hub and is inclined to be directed toward the longitudinal axis passing through the hub bore 1804.

[0225] Tongue valves 1814 are pivotally connected to and extend from hub 1802. Each tongue valve 1814 covers one of the connector ports 1722 and orifices 1725. A pivot portion 1816, also an integral part of the tongue valve unit 1800, pivotally connects each tongue valve 1814 to hub 1802. The pivot portion 1816 is formed of a portion of the material forming the valve and has a cross-sectional thickness thinner than the adjacent hub 1802 and tongue valve 1800. It should be appreciated that the valve 1814 covering port 1722 is generally planar with respect to hub 1802. The valve 1814 covering orifice 1725 forms an angle with hub 1802, here a right angle.

[0226] Each tongue valve 1814 is generally disc-shaped. The dimensions of each tongue valve 1814 are configured to cover the associated port 1722 and orifice 1725, and to abut against the area surrounding these ports. Generally, each tongue valve 1814 has a diameter approximately 4 mm larger than the inner diameter of the associated port 1722 and orifice 1725. Thus, one tongue valve 1814 abuts against surface 1720 while the other tongue valve 1814 abuts against the underside of wall 1724. The tongue valves 1814 function as one-way valves, allowing fluid to flow from ports 1722 and orifice 1725 into cavity 1704 and preventing fluid from flowing from cavity 1704 into ports 1722 and orifice 1725.

[0227] refer to Figure 39ADetails of tissue catcher 1850 are illustrated in 39B, 42A-42E, and 43. Tissue catcher 1850 is generally rectangular in shape. Other shapes such as circular, oval, or square may be used. Tissue catcher 1850 may be formed from any suitable material, such as low-hardness plastic or thermoplastic elastomer. Tissue catcher 1850 includes a retainer 1852 and a catch tray 1880. Retainer 1852 is defined by four plates including parallel and spaced-apart generally vertically oriented side beams 1854 and 1856 and parallel and spaced-apart generally vertically oriented front and rear beams 1858 and 1860. Side beams 1854 and 1856 have a lowered top edge 1857 that curves toward the center of the beam. A rounded flange 1862 extends outward from the outer periphery of front beam 1858 and has a flat portion or edge 1863 on its lower part. Retainer 1852 defines a hollow groove 1864 through which it passes. Both the retainer 1852 and the capture tray 1880 can be formed from injection-molded plastic. In an embodiment, the plastic can be transparent so that the contents of the tissue capture device 1850 are visible to the user.

[0228] A circular O-ring 1866 abuts against the proximal surface of the flange 1862. When the tissue trap 1850 is inserted into the aperture 1727, the O-ring 1866 provides a seal between the flange 1862 and the end 1706 of the cap. In one embodiment, the O-ring 1866 may be omitted. In this embodiment, the seal is formed directly between the flange 1862 and the end 1706 of the cap.

[0229] The retainer 1852 includes a pair of parallel, flat guide rails 1868 that extend vertically inward from the bottom inner surfaces of the side plates 1854 and 1856 into the groove 1864.

[0230] A filter or capture tray 1880 is removably engaged with a tissue trap 1850. The capture tray 1880 is generally rectangular in shape and is defined by four walls and a bottom mesh structure. The capture tray 1880 includes parallel and spaced-apart generally vertically oriented side walls 1882 and 1884 and parallel and spaced-apart generally vertically oriented front and rear walls 1886 and 1888. A bottom mesh structure or screen 1890 is mounted at the bottom of the walls 1882-1888. The walls 1882-1888 and the screen 1890 form an open-end shell (unidentified) defining a cavity 1894. The mesh structure 1890 includes perforations to allow fluid to pass through it. A lip 1892 extends outward from the top of the walls 1882-1888.

[0231] The filter or capture tray 1880 can be inserted into and removed from the retainer 1852. The filter or capture tray 1880 is placed within the retainer 1852 by inserting the capture tray 1880 into the slot 1864 and pressing it against the retainer until the bottom of the walls 1882-1888 abuts against the guide rail 1868 and the lip 1892 sits on the top of the walls 1882-1888. The filter or capture tray 1880 is removed from the retainer 1852 by lifting it out of the slot 1864.

[0232] Identification device 1896 is attached to the rear plate 1860 of tissue capture device 1850. Identification device 1896 can be any suitable identification device, such as a radio frequency identification (RFID) tag or device, barcode, magnetic stripe, or other storage device. The presence of identification device 1896 can be detected by sensor 1897 installed in housing 1699. Figure 36 ) is sensed. In one embodiment, sensor 1897 may be a Hall effect sensor. Sensor 1897 is used to detect insertion of tissue trap 1850 into cartridge 1700 and to turn on lamp 1898 ( Figure 36 This illuminates the interior of the trap 1850.

[0233] Option forms or embodiments of the tissue capture device 1900 are in Figure 44 and 45A As shown in -45E. The tissue trap 1900 is a single integral piece. The tissue trap 1900 is generally rectangular in shape. Other shapes, such as circular, oval, or square, can be utilized. The tissue trap 1900 can be formed from any suitable material, such as low-hardness plastic or thermoplastic elastomer. The tissue trap 1900 is defined by four plates, including parallel and spaced-apart generally vertically oriented side plates 1902 and 1904 and parallel and spaced-apart generally vertically oriented front and rear plates 1906 and 1908. A circular flange 1910 extends outward from the outer periphery of the front plate 1906 and has a flat portion or edge 1912 on its lower part. In embodiments of the tissue trap 1900, the use of an O-ring is omitted. A screen 1914 is mounted to the bottom of the plates 1902-1908 and forms the bottom of the tissue trap 1900. The screen 1914 includes perforations to allow fluid to pass through it. Plates 1902-1908 and screen 1914 define a cavity 1916. Identification device 1896 is attached to the rear plate 1908 of tissue capture device 1900.

[0234] In these forms of the invention, the flange 1910 serves as a cover over the opening 1727 in the manifold. In these forms of the invention, when specimen collection is not required, there is no cover attached to the screen 1914; essentially, the flange 1910 is positioned within the outlet. Fluid flows from the outlet through the space 1727 without any filtration or collection of the contained tissue. When it is useful to collect a specimen at a certain point during surgery, a tissue trap 1900 is inserted into this space. Tissue contained in the waste stream is captured by the screen 1914.

[0235] C. Operation of the Fourth Embodiment refer to Figure 1A -C, 35-38 and 43, by the user inserting the box 1700 into the complementary container 1699 associated with the can 36, movable unit 30 ( Figure 1A The user grasps the cover 1702 and inserts the box 1700 into the container 1699, causing the housing base 1752 to open the door 1634 and slide into the cavity 1610. The housing base is guided toward the valve disc 1632. For the movable unit 30 to function, the valve disc protrusion 1636 must be seated in the housing opening 1770. Locking grooves 1618 and 1620 and manifold protrusions 1708 and 1709 cooperate to ensure that the box 1700 is aligned with the valve disc 1632. Specifically, these components are positioned such that the positioning of the manifold protrusion 1608 in the groove 1618 causes the box 1700 to be rotated and positioned so that the housing opening 1770 is aligned with the valve disc protrusion 163. After the box is thus positioned, inserting the box 1700 further into the container 1699 causes the housing base 1752 to be mounted above the valve disc protrusion 1636.

[0236] Then, the housing 1700 is rotated, causing the valve disc protrusion 1636 and valve disc 1632 to rotate similarly. This rotation aligns the valve protrusion 1638 with the distal end opening leading to the conduit 59, allowing fluid to communicate between the cavity 1704 and the conduit 59.

[0237] Initially, when the box is placed within the housing 1699, the distal end of the box housing sits above the valve protrusion 1636. More specifically, the protrusion 1636 extends into the housing opening 1770. An eaves-shaped stop 1774 forms a fluid-impermeable barrier between the protrusion 1636 and the surrounding portion of the housing base 1750 defining the opening 1770.

[0238] Two aspiration lines can be attached to cassette 1700. If aspiration is required and tissue collection from the fluid flow is not necessary, the aspiration line through which the fluid flow passes is attached to connector 1732. This can be the connector to which the aspiration cannula is attached, which is then used by the anesthesiologist for aspiration. The aspiration line desired for collecting the tissue segment is attached to connector 1732. It should be noted that if the aspiration line is not attached to one of connectors 1732 or 1734, a cap is left on that connector. Therefore, the cap prevents unnecessary loss of aspiration through that connector.

[0239] The movable unit 30 is actuated by an actuating suction pump 58. This suction force is sufficient to bend the two tongue valves 1814 to their open position. If a suction line is attached to connector 1732, fluid is drawn through this suction line into the box cavity 1704. From cavity 1704, this fluid flows through conduit 59 into the associated tank body.

[0240] The suction force drawn by pump 58 also causes fluid flow to be drawn through the suction line attached to connector 1734. The flange 1862 of the trap 1850 serves as a cover removably mounted above the housing opening 1729. When flange 1862 is in this position, O-ring 1866 prevents suction force loss at the outer interface between the front end of the cartridge and the flange 1862 of the trap. When it is not desired to collect substances contained in this fluid flow, filter 1880 is not placed within the trap holder 1852. Fluid flows unfiltered through the cartridge and exits through conduit 59.

[0241] Alternatively, when the box is operating in this bypass mode, even the catcher 1850 is not installed on the box. A lid 1741 is installed over the box opening 1729. The lid 1741 may include a layer of resilient material. This resilient layer serves as a seal to prevent loss of suction force at the interface between the box and the lid.

[0242] The user can use the cartridge 1700 to collect tissue samples, such as polyps. If the cap 1741 is in place, it is removed by grasping the handle 1742 and manually pulling the cap 1741. The tissue catcher 1850, including the capture tray 1880, is inserted into the sleeve 1726. The user grasps the flange 1862 and positions the proximal plate 1860 through the opening 1729 within the sleeve 1726 and the aperture 1727. The tissue catcher 1850 slides into the sleeve 1726 until the O-ring 1866 abuts against the end 1706 of the cap. The O-ring 1866 provides a suction seal between the flange 1862 and the end 1706 of the cap. This mode of operation is referred to as the tissue sample collection mode because the aspiration fluid communication path passes through the tissue catcher 1850.

[0243] Alternatively, if the cover is not in place, the filter without the trap is simply removed from the housing. The filter 1880 is placed in the trap holder 1852. The trap is then repositioned in the sleeve 1726.

[0244] It should be recognized that the suction force is interrupted at the head of the suction applicator during the insertion of the filter into the box. This interruption of suction force is intended to substantially eliminate the possibility that the tissue of interest being collected by the physician may be accidentally aspirated through the box and into the waste collection container.

[0245] When the tissue trap 1850 is placed in the sleeve 1726, the sensor 1897 detects the presence of the tissue trap 1850 and identifies the identification device 1896. The sensor 1897 communicates with the controller 192 (…). Figure 1B (Connection). Controller 192 can turn on lamp 1898 to illuminate the interior of tissue capture device 1850.

[0246] In the tissue sample collection mode, waste stream is aspirated from the surgical site into the applicator 52 along the aspiration fluid communication path 184, and enters the connector 1734 via the aspiration line 50B. This waste stream may include tissue sample 398 contained in the aspiration applicator 52 due to the suction force of the aspiration through the applicator. From the connector 1734, the waste stream flows through the port 1728, cavity 1894, bottom mesh structure 1890, orifice 1725, tongue valve 1814, and cavity 1704 into the conduit 59. From the conduit 59, the waste stream flows into the tank 36.

[0247] Within the tissue capture device 1850, tissue sample 398 is captured via the bottom mesh structure 1890 of the capture tray 1880. This operating mode is referred to as tissue collection mode because the aspiration fluid communication path 184 passes through the tissue capture device 1850. Note that in order to collect samples in tissue collection mode, it is not necessary to disconnect and reconnect the aspiration line 50B.

[0248] The plastic forming the cover 1702 and the tissue trap 1850 is at least partially transparent to allow the user to see the tissue sample 398 within the cavity 1894. The tissue sample 398 is illuminated within the tissue trap 1850 by the light source 1898.

[0249] The tissue capture device 1850 is removed from the sleeve 1726 by the user manually pulling the flange 1862 in a direction parallel to the horizontal axis of the box 1700. After the tissue capture device 1850 is removed from the sleeve 1726, the capture tray 1880 containing the tissue sample 398 is removed from the retainer 1852. The user grasps and lifts the lip 1892 of the capture tray 1880 located at the lowered edge 1857 of the retainer 1852 to separate the capture tray 1880 from the retainer 1852.

[0250] For further reference Figure 14 After removing the tissue capture tray 1880, the user places the capture tray 1880 into the specimen container 380. Figure 14 Inside the specimen container 380, the tissue sample 398 is immersed in preservative solution 389. The user places the cap 390 onto the specimen container 380. The cap holder 392 aligns threads 391 and 387. As the cap 390 is rotated onto the specimen container 380, the protrusion 394 disengages, separating the cap 390 from the cap holder 392. The user can then pull the arm 395 to remove the cap holder 392 from the specimen container 380. The specimen container 380 is then sent to the pathology laboratory for analysis. The door 1741 can be repositioned onto the opening 1729 of the sleeve 1726 to prevent any loss of suction force.

[0251] It should be noted that this removal of the tissue trap 1850 interrupts the suction at the head of the aspiration applicator. This provides the physician with an opportunity to simply examine the captured tissue to ensure that all samples desired by the physician have been collected. If the physician determines that additional collection of this sample is necessary, the physician can reset this filter or install a new filter onto the cartridge.

[0252] If, later in the procedure, the physician deems it useful to collect another tissue sample, a second capture tray 1880 can be inserted into the retainer 1852, and the tissue capture device 1850 can be reinserted into the cannula 1726 and orifice 1727 for collecting the additional tissue sample. Multiple tissue samples can be collected using multiple sieves 1880. During the procedure, multiple tissue samples can be collected without disconnecting or reconnecting the aspiration suture 50B.

[0253] Once the medical / surgical procedure is complete and the movable unit 30 is no longer needed, the suction lines 50A and 50B can be disconnected from connectors 1732 and 1734, respectively. The cover 1740 is repositioned onto connectors 1732 and 1734, and the door 1741 is repositioned onto the opening 1729. The housing 1700 is then removed from the receiving seat 1699. The housing 1700 is rotated so that protrusions 1708 and 1709 align with slots 1618 and 1620, respectively. As a result of rotating the housing 1700, the valve disc 1632 undergoes the same rotation. This rotation of the valve disc 1632 reorients the disc, so that it once again covers the open end of the receiver adapter conduit 59.

[0254] Once the cassette 1700 is correctly positioned, it is manually withdrawn to the retractable seat 1699, closing the door 1634. After the camouflage stop 1774 passes the distal end of the valve disc protrusion 1632, the opposing portions of the camouflage stop's limiting slot 1790 move together to reclose the opening 1770. The closure of the opening 1770 effectively eliminates leakage of waste material remaining inside the cassette. The cassette 1700 and retainer 1852 are disposed of as medical waste.

[0255] After use, the movable unit 30 is engaged with the storage container (not shown in the figure and not part of the invention). Waste material in the tank 36 flows through the storage container into the treatment facility.

[0256] It should also be recognized that in this form of the invention, the plastic forming the cassette 1700 and the tissue trap 1850 is at least partially transparent. This provides medical personnel with a quick means of verifying that a tissue sample has been collected. Additionally, this provides medical personnel with a quick means of verifying that the cassette has not been previously used and does not contain previously collected waste.

[0257] Because the cassette 1700 is positioned at a slight angle or tilted upwards when placed in the reservoir 1699, the tissue trap 1850 is also tilted upwards slightly. Any liquid waste adhering to the tissue trap 1850 flows into the cannula 1726 upon removal, preventing waste leakage into the surgical environment.

[0258] The tilted orientation of the cassette 1700 ensures that, when the movable unit 30 is in operation, the proximal housing base opening 1770 is positioned below the inlet ports 1722 and 1728 in the direction of gravity. This prevents waste in the cassette from flowing upstream toward ports 1722, 1728 or the tissue trap 1850.

[0259] The tongue valve unit 1800 also prevents any waste from leaking from the housing 1700 into the suction lines 50A and 50B. When the suction pump 58 is actuated, the single tongue valve 1814 normally covers the port 1722 and orifice 1725, and the connector cover 1740 is removed. The suction force of the pump is sufficient to generate a pressure head that bends the tongue valve 1814 to the open position. Therefore, waste liquid can flow into the housing cavity 1704. When the pump fails, the pivot 1816 has sufficient elasticity to return the tongue valve 1814, which is against an adjacent surface or wall, to the closed position.

[0260] Using tissue catcher 1900, tissue samples can be collected in a similar manner to using tissue catcher 1850. Because tissue catcher 1900 is a single, integral unit and does not have a separate sieve, after the tissue sample has been collected using tissue catcher 1900 and tissue catcher 1900 has been removed from sleeve 1726, the entire tissue catcher 1900 will be placed in preservative container 380. To collect additional tissue samples, another unused tissue catcher 1900 will be inserted into sleeve 1726.

[0261] VI. Fifth Embodiment A. Box Now for reference Figure 46-4 8. Another embodiment of box 2000 is shown. Box 2000 and Figure 35 and 36 The housing 1699 in the box is used in conjunction with the box 2000. Box 2000 shares some common parts and features with box 1700. The outer shell 1750 and tissue catchers 1850 and 1900 of box 2000 are the same as those in box 1700 described previously. The internal features of lid 2002 are the same as those described previously with respect to lid 1702. However, the shell or housing 2018 is removable from lid 2002. The shell or housing 2018 of box 2000 is molded separately from the remainder of lid 2002. The shell or housing 1718 of lid 1702 is a single integral piece.

[0262] The box 2000 includes a housing 2001 having a proximal outer shell 1750 with a lid 2002 attached to the distal side and a removable sample housing or box 2018. The lid 2002 and the sample housing 2018 may be formed from a suitable material such as injection-molded plastic.

[0263] Cover 2002 has the same ends 1705 and 1706 and skirt as cover 1702. Cover 2002 is sized to allow housing 1701 to be placed in and rotate within the receiver 1699. At the proximal end 1705 of skirt 1707, two protrusions 1708 and 1709 extend radially outward (in... Figure 47 Only one protrusion 1708 is shown. Protrusion 1708 is designed to slide into the manifold seat locking groove 1618. Protrusion 1709 is designed to slide into the manifold seat locking groove 1620.

[0264] A semi-cylinder 1716 extends distally from the lower half of the skirt 1707. A semi-circular surface 1719 extends on the proximal end of the skirt 1707, and another semi-circular surface 1720 extends on the proximal end of the barrel 1716. A planar wall 1724 extends between surfaces 1719 and 1720. A pair of parallel, directly opposite, spaced-apart L-shaped guide rails 2004 extend vertically upward from the wall 1724. Elongated slots 2006 are provided along the length of each guide rail 2004. Circular apertures 1725 extend through the wall 1724 between the centers of the guide rails 2004 and are spaced apart from the surfaces 1720.

[0265] A roughly U-shaped semi-body flange 1736 extends away from surface 1720 in a distal direction. The connector 1732, integral with housing 1700, is integral with housing 2000. Like housing 1700, this connector 1732 serves as a connector through which fluid flow that does not require collection of tissue can be aspirated through housing 2000.

[0266] For further reference Figures 49A-49E The removable housing or enclosure 2018 is generally rectangular in shape and includes five sides or walls, including parallel and spaced-apart, generally horizontally oriented top and bottom walls 2040 and 2042; parallel and spaced-apart, generally vertically oriented side walls 2044 and 2046; and a generally vertically oriented back wall 2048 perpendicular to walls 2044 and 2046. The housing 2018 has ends 2036 and 2038. A semi-circular flange 2050 extends radially outward from walls 2040-2046 at end 2036. An elongated, raised keyway 2054 is positioned opposite to the bottom of side walls 2044 and 2046 and extends vertically along the length of each of side walls 2044 and 2046. When the sample housing 2018 is installed onto the cover 2002, the key bar 2054 slides into the groove 2006 of the guide rail 2004 and engages with it.

[0267] An elongated rectangular inner sleeve 2026 with an aperture 2027 is defined in a housing 2018 by walls 2040-2046. An opening 2030 is defined at the termination of the sleeve 2026 at a flange 2050. An aperture 2052 extends through a bottom wall 2042.

[0268] Connector 1734 extends vertically away from the top wall 2040. Connector 1734 is in the form of a hollow tube. The dimensions of connector 1734 are set to receive suction line 50B (…). Figure 36 Port 1728 is defined to pass through connector 1734 and be in fluid communication with orifice 2027.

[0269] The column 1738 extends vertically away from the top wall 2040, slightly spaced from the flange 2050 and the connector 1734. A removable cover 1740 is provided for connectors 1732 and 1734. A removable cover 1741 is provided to cover the opening 2030 of the sleeve 2026. Cover 1741 has a handle 1742 that can be gripped by a user and a portion that fits into the sleeve 1726. Each connector cover 1740 and cover 1741 is integrally attached to the sample housing 2018 via a fastener 1744 with multiple arms 1746. The arms 1746 are anchored to the column 1738.

[0270] The sample housing 2018 is attachable to the cover 2002. The user grasps the housing 2018 and aligns the key bar 2054 with the groove 2006 of the guide rail 2004. The housing 2018 is moved toward the surface 1719 in a proximal direction. The key bar 2054 slides along the guide rail 2004 until the rear wall 2048 contacts the surface 1719. In this position, the aperture 2052 of the housing 2018 is coaxially aligned with the aperture 1725 of the cover 2002. A fluid communication path is formed between the port 1728, the aperture 2027, the apertures 2052 and 1725, and the cavity 1704.

[0271] Sample housing 2018 is compatible with Figure 42A -E tissue trap 1850 or with Figure 45A -E is used in conjunction with the tissue catcher 1900. After the cover 1741 is removed from the opening 2030, the tissue catcher 1850 or 1900 can be inserted into the aperture 2027 to complete the box 2000 used in conjunction with the container 1699.

[0272] B. Operation of the Fifth Embodiment refer to Figure 1A -C, 36, 38B and 46-49, use box 2000 in a similar manner to box 1700, movable unit 30 ( Figure 1A The movable unit 30 is operated. It is prepared for use by the user inserting the box 2000 with the attached housing 2018 into the complementary reservoir 1699 associated with the canister 36. The user grasps the lid 2002 and inserts the box 2000 into the reservoir 1699, causing the housing base 1752 to open the door 1634 and slide into the cavity 1610. In a similar manner to that described above, the housing base 1752 rests against the valve disc 1632 and the lid 2002 is held in the reservoir 1699.

[0273] Actuation of the suction pump 58 causes fluid to be drawn through connectors 1732 and 1734. The fluid drawn through connector 1734 flows through housing sleeve 2026 and orifice 2052. After passing through housing orifice 2052, the fluid flows through box orifice 1725. In fact, the diameter of box orifice 1725 is larger than that of housing orifice 2052 and extends radially to the entire periphery of housing orifice 2052. This relative dimensional arrangement and positioning of these orifices effectively eliminates fluid leakage between the housing 2018 and the adjacent surfaces of the box.

[0274] The user can choose to use the cassette 2000 to collect tissue samples, such as polyps. The user removes the cap 1741 from the sleeve 2026 by grasping the handle 1742 and manually pulling 1741. The tissue catcher 1850 includes a capture tray 1880. Figure 42A -E) is inserted into the cannula 2026. The user can grasp the flange 1862 and position the near-side plate 1860 through the opening 2030 into the cannula 2026 and the orifice 2027. The tissue trap 1850 slides into the cannula 2026 until the O-ring 1866 abuts against the flange 2050. The O-ring 1866 provides a suction seal between the flange 1862 and the flange 2050. This operating mode is referred to as the tissue sample collection mode because the aspiration fluid communication path passes through the tissue trap 1850.

[0275] When the system is in tissue sample collection mode, waste stream is aspirated from the surgical site into applicator 52 along aspiration fluid communication path 184, and enters connector 1734 via aspiration line 50B. This waste stream may include tissue sample 398 contained in aspiration applicator 52 due to the suction force of the applicator. Starting from connector 1734, waste stream passes through port 1728, cavity 1894, bottom mesh structure 1890, pores 2052 and 1725, tongue valve 1814, and cavity 1704 into conduit 59. From conduit 59, waste stream flows into tank 36.

[0276] Within the tissue trap 1850, tissue sample 398 is captured by the bottom mesh structure 1890 of the capture tray 1880. This operating mode is referred to as tissue collection mode because the aspiration fluid communication path 184 passes through the tissue trap 1850. Note that in order to collect samples in tissue collection mode, it is not necessary to disconnect or reconnect the aspiration line 50B.

[0277] The tissue capture device 1850 is removed from the sleeve 2026 by the user manually pulling the flange 1862 in a direction parallel to the horizontal axis of the box 2000. After the tissue capture device 1850 is removed from the sleeve 2026, the capture tray 1880 containing the tissue sample 398 is removed from the retainer 1852. The user grasps and lifts the lip 1892 of the capture tray 1880 located at the lowered edge 1857 of the retainer 1852 to separate the capture tray 1880 from the retainer 1852.

[0278] After removing the tissue capture tray 1880, the user can place the capture tray 1880 into the specimen container as previously described.

[0279] If, later in the procedure, the physician deems it useful to collect another tissue sample, a second capture tray 1880 can be inserted into the retainer 1852, and the tissue capture device 1850 can be reinserted into the cannula 2026 and orifice 2027 for collecting the additional tissue sample. Multiple tissue samples can be collected using multiple sieves 1880. During the procedure, multiple tissue samples can be collected without disconnecting or reconnecting the aspiration suture 50B.

[0280] Using the tissue trap 1900 and box 2000, tissue samples can be collected in a similar manner to using the tissue trap 1900 and box 1700.

[0281] It should be noted that in some cases, if the movable unit 30 is used in multiple surgical procedures throughout the day, reusing some parts of the box 2000 in multiple surgical procedures can help reduce costs and the amount of medical waste generated. In particular, the lid 2002 and the outer shell 1750 of the box 2000 are reused throughout the day, while the tissue shell 2018 used with the movable unit 30 is replaced for each new patient.

[0282] The sample housing 2018 is removable from the cover 2002. Suction lines 50A and 50B are disconnected from connectors 1732 and 1734, respectively. The cover 1740 is repositioned onto connectors 1732 and 1734, and the door 1741 is repositioned onto the opening 2030. The user grasps the housing 2018 and pulls it, moving it away from surface 1719 in a distal direction. The key bar 2054 slides along guide rail 2004 until it separates from the guide rail 2004. The sample housing 2018 is then disposed of as medical waste. Another sample housing 2018 is then installed onto the cover 2002 as previously described.

[0283] At the end of the day, when those medical / surgical procedures are completed, the movable unit 30 is no longer needed, and the suction lines 50A and 50B can be disconnected from connectors 1732 and 1734, respectively. The cover 1740 is repositioned onto connectors 1732 and 1734, and the door 1741 is repositioned onto opening 2030. The box 2000 is removed from the container 1699 in the manner previously described. The box 2000 and retainer 1852 are disposed of as medical waste.

[0284] After use, the movable unit 30 is engaged with the storage container (not shown in the figure and not part of the invention). Waste material in the tank 36 flows through the storage container into the treatment facility.

[0285] It should also be recognized that in this form of the invention, the plastic forming the box 2000, which includes the housing 2018 and the tissue trap 1850, is at least partially transparent. This provides medical personnel with a quick means of verifying that a tissue sample has been collected. Additionally, this provides medical personnel with a quick means of verifying that the box has not been previously used and does not contain previously collected waste.

[0286] Similarly, when using the cassette 1700 to capture tissue, the aspiration flow is interrupted during the installation and removal of the capture device. This reduces the initial likelihood that tissue of interest may flow into the cassette before collection. After collection, this provides the physician with the opportunity to ensure that all tissue of interest has been collected before allowing unfiltered fluid to flow into the cassette.

[0287] VII. Rinse Box exist Figures 50-54 The diagram illustrates an irrigation assembly 2100 used in conjunction with the movable unit 30. The irrigation assembly 2100 delivers irrigation fluid to the surgical site via an irrigation fluid source. The irrigation assembly 2100 includes an irrigation cartridge 2102 and a water bottle 2200.

[0288] Water bottle 2200 is generally rectangular in shape. Other shapes, such as circular or oval, may be used. Water bottle 2200 is defined by six outer plates, including opposing parallel and spaced-apart generally vertically oriented plates 2202 and 2204; opposing parallel and spaced-apart generally vertically oriented plates 2206 and 2208; and a generally horizontally oriented bottom plate 2210. Top plate 2211 slopes inward from plates 2202, 2204, 2206, and 2208. Side plates 2202, 2204, 2206, and 2208 are perpendicular to bottom plate 2210. Water bottle 2200 has a top end 2214 and a bottom end 2212.

[0289] Plates 2202, 2204, 2206, 2208, 2210, and 2211 define a reservoir 2220 within the water bottle 2100. The water bottle 2100 may be formed from any suitable material, such as blow-molded plastic. In one embodiment, the water bottle 2100 is formed from a transparent material so that the contents or level of the reservoir 2120 can be seen by the user.

[0290] The water bottle 2100 has a neck 2224 extending away from the top wall 2211. An annular flange 2226 extends radially outward and surrounds the neck 2224. A thread 2228 is defined on the outer surface of the neck 2224 toward the end 2214. An opening 2230 allows access to the reservoir 2220.

[0291] A circular cap 2260 has threads 2262 defined on an inner annular surface of the cap and a knurled portion 2264 with grooves defined on an outer annular surface of the cap. The cap 2260 has a top wall 2266. A barbed connector 2268 extends perpendicularly away from the outer surface of the top wall 2266. The barbed connector 2268 has a hollow tube therein. A U-shaped protrusion 2270 also extends perpendicularly away from the outer surface of the top wall 2266. A hole 2272 is defined on the protrusion 2270. Holes 2274 and 2276 extend through the top wall 2266.

[0292] A duckbill valve 2280 is disposed in an orifice 2276 and extends toward the inner surface of the reservoir 2220 away from the wall 2266. The duckbill valve 2280 is formed of a compressible, elastic material such as polyisoprene rubber. The duckbill valve 2280 has a pair of lips, with a slot 2282 formed therebetween. During operation of the peristaltic pump 70, the duckbill valve 2280 allows air to be drawn into the reservoir 2220. Air can reach the reservoir 2220 from the external environment through the slot 2282. The liquid pressure from the contents of the reservoir 2220 presses against the lips of the duckbill valve 2280, keeping the slot 2282 closed and preventing any liquid leakage. Therefore, the duckbill valve 2280 is a one-way valve that allows air to flow into the water bottle 2200 and prevents liquid from leaving the water bottle 2200.

[0293] The rinsing cartridge 2102 is removably coupled to the water bottle 2200. The rinsing cartridge 2102 includes a generally Y-shaped housing 2104 and a hose or tube 2300. The housing 2104 has ends 2106, 2108, and 2110. Within the housing 2104, apertures 2112, 2114, and 2116 extend through the housing 2104 into an internal cavity 2120. An inwardly curved wall 2118 extends between ends 2108 and 2110.

[0294] The housing 2104 is formed by two separate, opposing halves or portions 2122 and 2150 that snap together along a seam 2124. Portion 2122 includes a planar wall 2123 and a curved outer peripheral sidewall 2124 having an edge 2126. The upper section of wall 2123 terminates along edge 2128. Sidewall 2124 is generally perpendicular to wall 2123. Portion 2150 has a planar wall 2152 and a pair of curved partial outer peripheral sidewalls 2154 and 2155 having edges 2156. Wall 2154 extends from end 2106 to end 2112. Wall 2155 extends from end 2106 to end 2114. The upper section of wall 2152 terminates along edge 2158. A curved, inverted Y-shaped wall 2118 is disposed within cavity 2120 and spaced apart from sidewalls 2154 and 2155. The curved wall 2118 is approximately perpendicular to the wall 2152. Multiple U-shaped tube retaining flanges 2119 are mounted to the wall 2152 and extend perpendicularly away from the wall 2152 into the cavity 2120.

[0295] Sidewalls 2154 and 2118 define outlet channel 2160. Sidewalls 2155 and 2118 define outlet channel 2162. A tine 2164 extends vertically inward from wall 2152 at edge 2158. A protrusion 2166 extends vertically inward from wall 2123 at edge 2128. The tine 2164 is sized to press-fit into and be received by a groove 2166.

[0296] The tube 2300 includes ends 2302 and 2304, a curved roller contact section 2306, and bends 2308, 2310, and 2312. The tube 2300 may be formed from any suitable material such as an elastomer or silicone rubber.

[0297] The rinsing box 2102 is assembled as follows: First, the tube 2300 is placed on the housing portion 2150 such that the bend 2310 is positioned within the channel 2160 and the bend 2308 is positioned within the channel 2162. The tube 2300 is pressed against the housing portion 2150 so that it slides into and is held within the tube retaining flange 2119. The end 2302 is positioned flush with the edge 2128. The curved roller contact section 2306 is adjacent to and in contact with the curved wall 2118. The end 2304 extends through the aperture 2116 and extends outside the side wall 2155. Then, the cover 2260 is positioned with the housing portion 2150 so that the handle 2164 is press-fitted through the cover hole 2272 and the end 2302 of the tube slides over the barbed connector 2268. The housing portions 2122 and 2150 fit together to form the housing 2104. The housing portions 2122 and 2150 are held together by press-fitting, snap-fitting, or welding. Other holding methods, such as adhesives, may be used. When the housing portions 2122 and 2150 are engaged, the handle 2164 is press-fitted into the groove 2166.

[0298] The flushing assembly 2100 is completed by threading a cap 2260 and a flushing cartridge 2102 onto a water bottle 2200. The water bottle 2200 is filled with flushing fluid. Rotating the cap 2260 causes the cap's thread 2262 to engage with the bottle's thread 2228. A flushing fluid communication path is formed to allow flushing fluid to flow from the reservoir 2220, through orifice 2274, connector 2268, and tube 2300 to tube end 2304. Tube end 2304 can be connected to a flushing line, for example... Figure 1A The rinsing line 51 is connected.

[0299] For details, please refer to the following: Figure 1A and 51 The rinsing assembly 2100 is adapted to be received by a rinsing assembly receiver 2400, which is part of the movable unit 30. The rinsing assembly receiver 2400 is positioned within a cover 42 of the movable unit 30. The cover 42 has an upper surface 2402. A rectangular slot 2410 extends from the surface 2402 into the cover 42 and has a bottom surface 2414. A rectangular peripheral step 2412 extends into the slot 2410. A countersunk hole 2420 is disposed above the slot 2410 and extends from the upper surface 2402 into the slot 2410, defining an annular step 2422.

[0300] The peristaltic pump 70 includes a rotary motor 71 engaged with a cover 42, which is connected to an eccentric roller 74 via a shaft 72. The motor 71 causes the roller 74 to rotate. The roller 74 of the peristaltic pump presses the curved pipe section 2306 against the wall 2118, forcing the flushing fluid through the pipe 2300.

[0301] A flushing assembly 2100 is prepared for the user to manually insert into the slot 2410 and countersunk hole 2420, so that the housing 2104 rests on the step 2412 and the cover 2260 rests on the step 2422. In this position, the roller 74 of the peristaltic pump engages with the curved pipe section 2306 and presses the curved pipe section 2306 against the wall 2118. The pipe end 2304 is connected to the flushing line 51 connected to the applicator 52.

[0302] Actuation of motor 71 and peristaltic pump 70 causes irrigation fluid to be pumped from water bottle 2200 reservoir 2220 along irrigation fluid communication path 182, through orifice 2274, connector 2268 and tube 2300 to tube end 2304, irrigation line 51 and applicator 52, where it will be supplied to the surgical site.

[0303] refer to Figure 55 and 56 Alternative embodiments of the irrigation assembly 2500 used with the movable unit 30 are in Figures 50-54 The diagram illustrates that the rinsing assembly 2500 includes a rinsing cartridge 2502 and a water bottle 2200. The rinsing cartridge 2502 has the same features as the rinsing cartridge 2102, except that the rinsing cartridge 2502 is oriented perpendicular to or at right angle to the water bottle 2200 rather than parallel to it.

[0304] VIII. Sixth Embodiment Figure 57 and 58 An alternative box 2600 of the present invention is illustrated. Box 2600 is a variation of box 1700. Box 2600 includes a proximal housing 2602. The shape and structure of housing 2602 are similar to housing 1750. A cover 2610 is disposed on the distal end of housing 2602. A sleeve 2640 extends forward from cover 2610. The sleeve 2640 is formed with a void space 2652 extending inwardly from the open proximal end of the sleeve. A screen holder 2702 is shaped to be slidably received within the void space 2652. The screen holder is shaped to removably support a capture tray 2740 including a filter or screen 2741.

[0305] As can be seen, housing 2602 is shaped to have parallel grooves (not identified) extending along the outer wall of housing. These grooves are not relevant to the present invention. Housing 2602 defines a void 2604 through which fluid flows before being discharged from outlet 2606. Filter 2605 is shown as removably mounted within the void space 2604 of housing. The means of placing filter 2605 within housing 2602 is not part of the present invention.

[0306] about Figure 57The lid 2610 described in 59 and 60 is formed as a single-piece unit and is shaped to have a cylindrical skirt 2612. The skirt 2612 is sized to extend around the open distal end of the housing 2602. A generally circular end plate 2614 extends inward from the distal end of the skirt 2612. The end plate 2614 forms the distal end of the lid 2610. A connector 2616 extends outward from the end plate 2614 of the lid. The connector 2616 is designed to receive a suction line 50. An aperture (aperture not identified) through the connector 2616 leads to a void space 2604 of the box 2600 defined by the housing 2602 and the lid 2610. In the illustrated form of the invention, the connector 2616 extends forward from a radially spaced position away from the central longitudinal axis of the box 2600, i.e., the axis passing through the plate 2614, and when the box 2600 is located in the housing 1699, the box 2600 is rotated about the axis passing through the plate 2614.

[0307] 2640 sleeve, in Figure 57 As best seen in 59 and 60, the sleeve 2640 is integrally formed with the cover 2610. The sleeve 2640 extends forward from the end plate 2614 of the cover. In the illustrated form of the invention, the cross-section of the outer body of the sleeve 2640 is rectangular. It should be understood that this design feature is not limiting. An elliptical panel 2642 extends around the distal end of the sleeve 2640. In the illustrated form of the invention, the main axis, i.e., the longitudinal axis passing through the panel, and the central axis passing through the connector 2616, are positioned on opposite sides in the diametrical direction of the longitudinal axis passing through the box 2600.

[0308] The panel 2642 is formed having two elliptical webs, webs 2644 and 2648, projecting forward distally. One web, web 2644, extends forward from the outer periphery of the panel 2642. The second web, web 2648, is a closed annular web similar to web 2644 and is disposed inwardly from web 2644. A compressible seal 2646 is compressed between webs 2644 and 2648.

[0309] The sleeve 2640 is formed such that the void space 2652 extends inward from the panel 2642. The sleeve 2642 is formed such that the void space 2652 includes an upper cavity 2654 and a lower cavity 2656. The upper cavity 2654 has a substantially rectangular cross-section. The upper cavity 2654 terminates on the inner surface of the sleeve 2640. The lower cavity 2656 of the sleeve is disposed just below the upper cavity 2654. The lower cavity 2656 has a generally rectangular cross-section. Although the lower cavity 2656 has approximately the same length as the upper cavity 2654, its cross-sectional height and width are smaller than those of the upper cavity 2654. The void space also includes a groove 2658 disposed below the lower cavity 2656. The groove 2658 extends the length of the lower cavity 2656. The cross-sectional shape of the groove 2658 is semi-circular. The widest part of the groove 2658, which is directly continuous with the lower cavity 2656, has a width smaller than that of the lower cavity.

[0310] In many forms of the invention, the longitudinally extending inner surface of the sleeve 2640 defining the top of the upper cavity 2654 and the longitudinally extending inner surface defining the base of the groove 2658 are parallel to each other. For manufacturing reasons, these surfaces are slightly offset from a perpendicular line relative to the plane of the sleeve panel 2642. Furthermore, the sleeve clearance space 2652 does not extend perpendicularly relative to the sleeve panel 2642.

[0311] The cover 2610 is further formed such that the connector 2664 extends away from the upper surface of the sleeve 2640. The connector 2664 is shaped to receive the suction line 50. The aperture through the connector opens to the top of the upper cavity 2654 of the void space 2642. The cover 2610 is also shaped such that adjacent to the distal end of the void space is an opening 2666 providing a fluid path through the cover end plate 2614. The opening 2666 is circular in shape. The cover 2610 is shaped such that the adjacent side ends of the groove 2658 and the distal cavity extend to the opening 2666. The connector 2616 and the opening 2666 are located on opposite sides of the longitudinal axis of the box extending through the end plate 2614.

[0312] In the illustrative representation of the invention, the sleeve 2640 is shown as having an end-closed aperture 2670. The aperture extends forward from the end plate 2614 of the cap. The aperture 2670 is designed for manufacturing purposes and is otherwise irrelevant to the invention.

[0313] A cylindrical protrusion 2678 extends inward from the proximal inner surface of the end plate 2614 of the cover. The protrusion 2678 is generally cylindrical in shape. A base 2676 extends around the portion of the protrusion 2678 that protrudes outward from the end plate 2614. The outer diameter of the base is larger than the outer diameter of the protrusion 2676.

[0314] When the housing 2600 of the present invention is assembled, the valve assembly 2682, only when... Figure 58As can be seen, it is mounted on the base 2676 and the protrusion 2678. Valve assembly 2682 is substantially the same as valve assembly 1800. Valve assembly 2682 is positioned such that one tongue valve 1814 is located on the proximal open end of connector 2616. A second tongue valve is mounted on a structural feature defining an opening 2666 of cover 2610. Valve assembly 2682 has a hub (unidentified) mounted above the base 2676. A ring 2684 press-fitted onto the protrusion 2678 holds the hub and the entire valve assembly to cover end plate 2614.

[0315] In the illustrated form of the invention, cover 2610 has a tube 2688 coaxial with a connector 2616 extending to the outside of the inner surface of end plate 2614. Tube 2690 extends proximally from and around opening 2666. Both tubes 2688 and 2690 have proximally inclined, non-perpendicular ends relative to the longitudinal axis passing through housing 2600. Tongue valve 1814 sits abutting these proximally end openings of tubes 2688 and 2690. Due to the elastic properties of the material forming valve assembly 2682, valve 1814 is biased to be pressed against the proximally ends of tubes 2688 and 2690.

[0316] The connector cap 2687 is molded together with the box cap 2610. A flexible fastener 2686, also part of the molded assembly, extends from the distal end of the skirt 2612 to retain the connector cap 2687 to the box cap 2610.

[0317] Now about Figure 61A and 61B The screen retainer 2702, sometimes also called a tissue trap, is described. The screen retainer 2702 is formed as a single-part unit. The screen retainer 2702 is shaped as a panel 2704. The panel 2704 is shaped such that the outer periphery of the proximal surface of the panel rests against a seal 2646. A pull tab 2706 extends perpendicularly away from the distal surface of the panel 2704, which is typically the exposed surface. The screen retainer 2702 is shaped such that the pull tab 2706 extends away from the upper portion of the panel 2704. The screen retainer is also shaped such that a recess 2708 extends inwardly from the exposed surface of the panel 2704. The recess 2708 is used for shaping purposes.

[0318] The tray retainer 2712 extends from the proximal surface of the panel 2704, which is typically concealed. The tray retainer 2712 is generally in the form of a U-shaped beam, where the opposite ends of the beam are the portions adjacent to the panel 2704. The tray retainer 2712 is formed such that the curved, semi-circular portion of the tray retainer has a plurality of spaced-apart fingers 2714. Protrusions 2716 extend inwardly from two of the fingers 2714. The tray retainer 2712 is further shaped such that small triangular ribs 2718 (only one shown in the figure) extend outwardly from the opposite side surface of the retainer. The tray retainer is formed such that the width from side to side between the outermost surfaces of the opposite ribs 2718 is approximately 0.5 mm larger than the cross-sectional width of the upper cavity 2654 spanning the interior of the sleeve 2640. Edges 2720 (two shown) extend inwardly from the inwardly pointing surface of the tray retainer 2712. Edge 2720 is configured to be adjacent to the bottom edge of tray retainer 2712.

[0319] Two legs, legs 2724 and 2728, extend downward from tray holder 2720. Leg 2724, the distal of the two legs, extends directly downward from tray holder 2720. Although in Figure 61B The middle part is not obvious, but leg 2724 is located on the proximal side opposite to panel 2704. Leg 2728, the proximal one of the two legs, extends downward and forward distally from the curved proximal end of the tray holder. Slide 2726 extends between the free ends of legs 2724 and 2728. Legs 2724 and 2728 and slide 2726 are sized to fit within a groove 2658 inside sleeve 2640.

[0320] The capture tray 2740 is similar in design to the capture tray 1880. The screen 2741, used for obtaining the tissue, is... Figure 57 The base forming the capture tray is shown. Screen 2741 is substantially the same as screen 1890. A set of walls 2742 extends upward from the outer periphery of the screen. Edges 2744 extend outward from the top edge of the walls 2742. The capture tray 2740 is sized to be positioned within a gap defined by the opposing sides and proximal ends of the tray holder 2720. The capture tray 2740 is also sized such that, when the tray is placed, the curved sidewalls on the proximal side of the tray's proximal end abut against the protrusions 2716 of the tray holder, causing the fingers 2714 to bend outward. The forces exerted on the capture tray 2740 by the fingers 2714 and protrusions 2716 of the tray holder as they attempt to return to their unbiased positions serve to removably retain the tray in the tray holder 2712.

[0321] In some forms of the invention, the components forming the housing 2600 are configured such that when the capture tray 2740 is mounted to the tray holder 2712, the distance from the bottom surface of the slide 2726 to the top surface of the edge 2744 of the capture tray is approximately 0.5 mm greater than the top-to-bottom height of the surfaces inside the sleeve 2640 that define the top of the upper cavity 2654 and the base of the groove 2658.

[0322] Box 2600, similar to box 1700, is usable by inserting box 2600 into receiver 1699 and rotating it within it, as in... Figure 62 As seen in the image. A suction line 50 containing a tissue sample of value is attached to connector 2664. A suction line 50 not containing a tissue sample of value is attached to connector 2616. In this form of the invention, it should be appreciated that the sleeve 2640 and therefore the void space 2652 are spaced forward from the remainder of the housing 2600.

[0323] The screen retainer 2702 is housed within the sleeve cavity space 2652. Because the width between the outer surfaces of the ribs 2718 of the screen retainer is slightly greater than the width of the upper cavity 2654 spanning the cavity space 2652, the ribs press against the inner surface of the sleeve 2640 defining the cavity 2652. This serves to hold the screen retainer 2704 to the sleeve 2640 with slight compression. During periods when specimen collection from the fluid flow through the connector 2664 is not required, the capture tray is not mounted within the tray retainer 2740. When the cassette 2600 operates in this state, fluid flows from the connector 2664 through the cavity space 2652 and the opening 2666. From the opening 2664, fluid flows across the filter 2605 into the cavity space 2604 and exits through the outlet 2606. Because the capture tray 2740 is not installed on the screen retainer 2704, this fluid flow is not filtered as it passes through the gap space 2652 of the sleeve.

[0324] It should be recognized that during the operation of box 2600, the inner surface of the panel 2704 of the screen retainer is positioned against the seal 2646. The panel 2704 abuts against the seal 2646 to prevent the loss of suction force at the interface between the sleeve 2640 and the screen retainer 2702.

[0325] When specimen collection is useful, the screen retainer 2702 is removed from the sleeve 2640 so that the capture tray 2740 can be installed to the retainer. This step can be performed while maintaining suction on the cassette 2600. The screen retainer 2702 is removed by pulling the pull tab 2706. More specifically, due to the positioning of the pull tab 2706, pulling the protrusion causes the panel 2704 of the screen retainer to pivot outward and downward relative to the seal 2646 installed to the sleeve 2640. In other words, by using the panel 2704 as an operating lever, performing this step alone can break the suction holding the plate to the sleeve 2640.

[0326] Once the screen retainer 2702 is removed from the sleeve 2640, the capture tray 2740 is placed within the tray retainer 2712. As discussed above, due to the bending of the fingers 2714, the fingers 2714 and protrusions 2716 of the tray retainer releasably hold the capture tray in the gap within the tray retainer 2712. The screen retainer is then reinserted into the gap space 2652 of the sleeve.

[0327] In this invention, the legs 2724 and 2728 of the tray retainer are bent in a form where the height from top to bottom between the edge 2744 of the capture tray and the slide 2726 is greater than the height from top to bottom between the top of the upper cavity 2654 and the base of the groove 2658. Due to the elastic properties of the material forming the screen retainer 2702, the legs 2724 and 2728 exert a force on the capture tray 2740 via the tray retainer 2712. This force pushes the edge 2744 of the capture tray against the inner surface of the sleeve 2640 defining the upper cavity 2654. This serves to ensure that substantially the entire flow of fluid from the connector 2666 passes through the screen integral with the capture tray 2640 as fluid flows through the gap space 2652 of the screen. Thus, all large matter in this fluid flow, ideally tissue that the physician wishes to capture for research, is captured in the capture tray 2740.

[0328] It should be recognized that due to this design of the cassette 2600, the sleeve 2640 is positioned in front of the manifold container 1690. Typically, the cassette 2600, or at least the sleeve 2640, is formed of a transparent material. Overall, these features of the invention allow medical personnel to observe the flow through the void space 2652 of the sleeve before the fluid flow enters the waste collection unit. This enables medical personnel to determine when tissue required for research will be captured in the capture tray 2740.

[0329] The ability to quickly observe the capture tray 2740 is further enhanced by positioning the sleeve 2640 in front of the remainder of the box 2600, the box housing. This prominent positioning of the sleeve naturally directs the eye towards the sleeve and the capture tray housed within it.

[0330] In an alternative form of this embodiment of the invention, the capture tray and the screen holder are integrated. In these forms of the invention, an additional component, in fact only panel 2704, is also provided. This panel serves as a second cover to the sleeve 2640 when it is not necessary to collect specimens from the liquid flow discharged into the box through connector 2666.

[0331] IX. Alternative Embodiments While the present invention has been described with reference to exemplary embodiments, it will be understood by those skilled in the art that various changes can be made without departing from the scope of the invention, and equivalent structures can be used to replace those elements and features. For example, it is contemplated that elements and / or features of one embodiment may be combined with or replaced by elements and / or features of another embodiment. Furthermore, many modifications can be made to the teachings of the invention to adapt to particular systems, apparatuses, or components without departing from the essential scope of the invention. The invention is not intended to be limited to the embodiments disclosed herein for carrying out the invention.

[0332] For example, not all forms of the invention may have all the features described. Features of different embodiments of the invention may be combined. Similarly, not all forms of the invention need to include the highly mobile waste collection unit, trolley 30, described herein. For example, in some forms of the invention, the waste collection unit may simply consist of a movable or stationary unit connected to an external suction source. A manifold housing and complementary manifolds are mounted to the waste collection unit.

[0333] For example, not all forms of the invention need to include a mechanism for supplying irrigation fluid, except for those used as aspiration catheters. Similarly, while the system is generally designed as part of a system for collecting medical waste, other forms of the invention may not have this function. Therefore, some forms of the invention may simply have a relatively small tank, capable of holding 10 liters or less of waste. In these forms of the invention, waste is collected only as a byproduct of the primary objective of performing surgery to extract tissue. In these forms of the invention, it should be appreciated that the tank therefore does not include components to facilitate pumping fluid to the site of aspiration.

[0334] Similarly, the use of this invention is not limited to systems for collecting tissue from the gastrointestinal tract. In other forms of the invention, the aspiration applicator may be designed for insertion into the esophagus. Thus, the aspiration applicator is used to aspirate material, including tissue from the esophagus or stomach. Yet another form of the invention can be used with a device inserted into a lung passage. These forms of the invention can be used to selectively extract tissue from these passages or from the lungs.

[0335] In some embodiments of the invention, the cartridge may have its own filter. When the system is not in tissue collection mode, the fluid flow drawn back from the site of application of the aspiration applicator passes through this filter. This filter thus serves to capture solids that may harmfully affect the operation of other components of the waste collection unit. These solids include sutures and tissue particles that the physician does not wish to retain for further research.

[0336] In this form of the invention, the tissue trap is selectively positioned in line with the cartridge filter so that it is upstream of the cartridge filter. The tissue trap is positioned in line with the cartridge filter when a physician becomes aware that a tissue segment is contained in the fluid flow by positioning the tissue trap or actuating the valve.

[0337] In relation to Figure 35-44 In the described form of the invention, the screen 1890 does not necessarily have to be rectangular. In some forms of the invention, if the screen is curved, a single wall may extend around the outer periphery of the screen to define a cavity for capturing tissue. Similarly, a second connector, i.e., connector 1732, is not required in all forms of this embodiment of the invention. Alternatively, alternative means may be provided for releasably retaining the capture tray 1880 to the retainer 1852. These alternative engagement mechanisms include magnets and snap-fit ​​connectors. In forms of the invention where the capture tray is suspended to the retainer, the tray may be suspended from a single beam extending from the retainer.

[0338] The backflow prevention valves that prevent backflow through connectors 1732 and 1734 may differ from those already described. For example, a one-way valve, such as an umbrella valve, may be installed on each of connectors 1732 and 1734.

[0339] Similarly, in some embodiments of the invention, the outlet 1770 on the box may be located at the center of the proximal end base of the box. Likewise, not all boxes of the invention need to be designed to rotate within a complementary receiver, which is a complementary shell with cylindrical sidewalls. In alternative embodiments of the invention, the shell may have a polygonal shape.

[0340] The advantage of this form of the invention is that the aspirated fluid stream is always filtered to prevent potentially damaging substances from being introduced into downstream components of the collection system. When it is desired to preserve tissue segments for research, the tissue can be extracted without having to be removed from a waste-filled cartridge filter. The fasteners holding the cap 1740 to connectors 1732 and 1734 can be eliminated. Furthermore, a bypass connector, i.e., connector 1732, is not required for the cartridge in all forms of the invention. In other forms of the invention, multiple bypass connectors may be provided to any of the cartridges of the invention.

[0341] Other structures besides O-rings, such as gaskets, can provide a seal between the caps 1862.

[0342] Various devices can be used to control the components of the present invention. For example, a foot switch assembly (not shown) may be provided. One or more foot switches integrated with this assembly can be used to control a suction pump or a flushing pump. Therefore, the purpose of the appended claims is to cover all such variations and modifications that fall within the spirit and scope of the invention.

Claims

1. A box for use with a medical waste collection system, the medical waste collection system comprising at least one container for receiving waste and a housing connected to said at least one container, the box comprising: A housing, which is shaped to be inserted into the receptacle, the housing having opposite proximal and distal ends and a housing void space; A connector, which is shaped to receive a suction line, is connected to a housing such that fluid drawn through the suction line flows into the void space of the housing. An outlet located in the proximal end of the housing, through which fluid is configured to flow from the housing void space through the outlet and via a reservoir to at least one tank. A sleeve, which is shaped to define a sleeve void space; a first sleeve opening located between the outside and the void space; A second sleeve opening is located between the sleeve gap space and the housing gap space; the connector is attached to the sleeve such that the connector is open to the sleeve gap space. A screen is formed such that it can be removably inserted into the sleeve gap space through the first sleeve opening and positioned between the connector and the second sleeve opening, such that fluid entering the sleeve gap space flows through the connector and through the screen. and A cover, which is shaped to be removably attached to the sleeve to cover the opening of the first sleeve, wherein the sleeve is attached to the housing adjacent to the distal end of the housing, such that when the housing is inserted into the receptacle, the sleeve is positioned in front of the receptacle to be visible, wherein the sleeve is formed of at least partially transparent material so that the sleeve void space is visible.

2. The box according to claim 1, wherein, The housing includes a plate forming the distal end of the housing; and wherein the sleeve is attached to the housing to extend forward from the plate.

3. The box according to claim 1 or 2, wherein, The screen is removably mounted to the cover such that when the screen is mounted to the cover and the cover is mounted to the sleeve, the screen is positioned within the sleeve gap space.

4. The box according to claim 1, wherein, The screen is part of a capture tray, which has walls extending around the screen.

5. The box according to claim 2, wherein, The connector is a first connector, and the box also includes a second connector for receiving another suction line, wherein the second connector extends from the housing and opens directly into the housing cavity space.

6. The box according to claim 5, wherein, The second connector extends from the plate.

7. The box according to claim 5, further comprising: A first backflow prevention valve is installed in the housing and configured to prevent backflow from the housing void space through the second sleeve opening into the sleeve void space; and A second backflow prevention valve is installed in the housing and configured to prevent backflow from the housing void space into the second connector.

8. The box according to claim 7, wherein, The first backflow prevention valve and the second backflow prevention valve are formed as a single unit.

9. The box of claim 8, further comprising a protrusion extending inwardly from the proximal inner surface of the plate, the single unit being disposed on the protrusion.

10. The box according to claim 1, wherein, The sleeve is internally shaped into an elongated rectangle, including a first sleeve opening defined in the housing by a wall.

11. The box according to claim 1, wherein, The sleeve is formed such that the sleeve gap space includes an upper cavity and a lower cavity, the lower cavity being located just below the upper cavity and having a smaller cross-sectional height and width than the upper cavity.

12. The box according to claim 11, wherein, The sleeve is formed with a groove that extends the length of the lower cavity and has a semi-circular cross-sectional shape.

13. The box according to claim 11, wherein, The connector extends away from the upper surface of the sleeve, causing an aperture to open to the top of the upper cavity of the sleeve's void space.

14. The housing according to claim 1, further comprising a filter removably mounted within the housing cavity space.

15. The box according to claim 1, wherein, The sleeve and the housing are integral.

16. A manifold box for collecting tissue samples together with a medical waste collection assembly, the medical waste collection assembly including a manifold container defining an aspiration inlet, the manifold box comprising: A housing comprising an inlet connector defining an inlet orifice and adapted to receive a suction line, at least one wall defining a chamber, an auxiliary sleeve defining an auxiliary opening in fluid communication with the chamber, and a base defining an outlet, wherein the auxiliary sleeve includes an internal wall defining an orifice providing fluid communication between the auxiliary sleeve and the chamber, wherein the outlet is configured to be arranged in fluid communication with a suction inlet of the medical waste collection assembly to define a suction path from the inlet orifice through the auxiliary sleeve, the orifice, the chamber, and the outlet to the suction inlet; A tissue trap includes a screen defining a porous feature and at least one sidewall extending from the screen to define a cavity, wherein the tissue trap is configured for removable connection to the housing, with the screen positioned within the auxiliary sleeve and adjacent to the inner wall, such that the cavity collects tissue samples held in the cavity as liquid waste passes through the porous feature and the pores. and A backflow prevention valve, which is coupled to the housing and configured to cover the orifice to prevent backflow from the chamber into the auxiliary cannula, the tissue trap being removably disposed within the auxiliary cannula.

17. The manifold box according to claim 16, wherein, The backflow prevention valve is a tongue-shaped valve unit, which is mounted on a protrusion extending from the inside of the end plate of the housing.

18. The manifold box according to claim 17, wherein, The tongue-shaped valve unit includes a first tongue portion that covers the orifice and a second tongue portion that covers the bypass orifice of the bypass connector extending forward from the end plate.

19. The manifold box according to claim 16, wherein, A filter element is disposed within the chamber, and a backflow prevention valve is positioned between the tissue trap and the filter element.

20. The manifold box according to claim 16, wherein, The tissue trap includes a panel and a pull tab extending from the panel, wherein the pull tab is configured to be pulled to pivot the panel in order to disrupt the suction force holding the panel to the auxiliary sleeve.

21. The manifold box according to claim 16, wherein, The housing includes an outer shell portion and a cover portion, the outer shell portion being configured to be inserted into a manifold container of a medical waste collection assembly, the cover portion being coupled to the outer shell portion and configured to be positioned in front of the manifold container when the outer shell portion of the manifold container is disposed within the manifold container, the outer shell portion defining the chamber and the cover portion defining the auxiliary sleeve.

22. The manifold box according to claim 21, wherein, The auxiliary sleeve extends forward to the cover panel of the cover portion.

23. The manifold box according to claim 16, wherein, The auxiliary sleeve has a cavity and a lower cavity, wherein the cross-sectional height and cross-sectional width of the lower cavity are smaller than those of the upper cavity.

24. The manifold box according to claim 23, wherein, The void space includes a groove disposed below the lower cavity and extending the length of the lower cavity.

25. The manifold box according to claim 24, wherein, The widest part of the groove is continuous with the lower cavity and has a width smaller than that of the lower cavity.

26. The manifold box according to claim 24, wherein, The upper cavity has a rectangular cross-section, the lower cavity has a rectangular cross-section, and the groove has a semi-circular cross-sectional shape.

27. The manifold box according to claim 23, wherein, The tissue trap is configured such that its side-to-side width is greater than the cross-sectional width of the lower cavity spanning the interior of the auxiliary sleeve.

28. The manifold box according to claim 23, wherein, The inlet orifice through the inlet connector opens to the top of the upper cavity of the auxiliary sleeve.

29. The manifold box according to claim 16 or 22, wherein, The auxiliary cannula is at least partially formed of a partially transparent material so that the tissue sample supported by the tissue trap is visible.

30. The manifold box of claim 16, further comprising a cover configured to be removably disposed on the cannula opening when the tissue capture device is not removably inserted into the cannula opening of the auxiliary cannula.

31. The manifold box of claim 30, further comprising a fastener for connecting the cover to the housing.

32. The manifold box of claim 16, further comprising an identification device coupled to a top plate of the housing and containing information including controls for reuse or reprocessing, wherein the information is usable by a medical waste collection assembly to allow or prevent operation of the medical waste collection assembly when the manifold box is placed in a manifold housing, wherein the identification device is one of an RFID device, a barcode, and a magnetic stripe.

33. The manifold box according to claim 16, wherein, The front-to-back axis extending through the auxiliary sleeve in the front-to-back direction is offset from the central axis of the manifold box.

34. A manifold box for collecting tissue samples together with a medical waste collection assembly including a manifold container, the manifold box comprising: A housing including an inlet connector adapted to receive a suction line, the housing being shaped to be removably coupled to a manifold container of the medical waste collection assembly to establish a suction fluid flow path from the suction line through the manifold box to the manifold container. A tissue trap, configured to be removably mounted to the housing for selectively arranged in series with an aspiration fluid communication path aspirated through a manifold, the tissue trap including a sieve for trapping tissue samples contained in the fluid; and An identification device, which is coupled to the top plate of the housing and contains information including controls for reuse or reprocessing, which can be used by the medical waste collection assembly to allow or prevent operation of the medical waste collection assembly when the manifold box is placed in the manifold housing.

35. The manifold box according to claim 34, wherein, The information also includes one or more of the following: installation information, expiration information, patient tracking information, and specimen tracking information.

36. A manifold box for use with a medical waste collection assembly including a reservoir to collect tissue samples, the manifold box comprising: The proximal housing, which defines the outlet, is configured to be removably coupled to the reservoir of the medical waste collection assembly; A cover attached to the proximal housing to define the housing void space; A filter disposed within the void space of the housing; An auxiliary sleeve extends forward from the cover and includes a sleeve panel, wherein the auxiliary sleeve forms a sleeve gap space extending inward from the sleeve panel. An inlet connector, extending away from the auxiliary sleeve and configured to receive a suction line, wherein the inlet connector defines an aperture in fluid communication with the sleeve void space; and An organization trap includes a screen panel, a screen, and a pull tab extending away from the screen panel, wherein the screen is configured to be positioned within the screen gap space when the screen panel is set against a sleeve panel. The tissue trap further includes a panel and a pull tab extending from the panel, wherein the pull tab is configured to be pulled to pivot the panel in order to disrupt the suction force holding the panel to the sleeve.

37. A manifold box for use with a medical waste collection assembly, the manifold box comprising: A housing comprising a cover portion and an outer shell portion coupled to the cover portion to define a chamber, the outer shell portion having an outlet at a proximal end, and the cover portion comprising: End cap plate; A sleeve extending forward or distally from the end plate defines a void space in fluid communication with the chamber; An inlet fitting extends from the sleeve and defines an aperture that opens into the void space; and A tissue trap includes a sieve defining a porous feature, the tissue trap being configured to be removably coupled to the housing, with the sieve positioned within the void space for collecting tissue samples as fluid waste passes through the porous feature during operation of the medical waste collection assembly. The front-to-back axis extending through the sleeve in the front-to-back direction is offset from the central axis of the manifold box toward the sleeve, and the end cap plate rotates around the central axis during the connection of the manifold box with the medical waste collection assembly.

38. The manifold box according to claim 37, further comprising a tongue valve unit connected to the interior of the end cap plate.

39. The manifold box according to claim 37, wherein, The sleeve is configured to be positioned in front of the manifold housing of the medical waste collection assembly when the outer shell portion of the manifold box is disposed within the manifold housing.

40. A manifold box for use with a medical waste collection assembly, the manifold box comprising: A housing comprising a cover portion and an outer shell portion coupled to the cover portion to define a chamber, the outer shell portion including a distal base defining an outlet, the cover portion including a sleeve defining a void space in fluid communication with the chamber and an inlet connector defining an aperture opening into the void space; and A tissue trap includes a sieve defining a porous feature, the sieve being configured for removable positioning within the porous space to collect tissue samples as fluid waste passes through the porous feature during operation of a medical waste collection assembly. The sleeve is formed such that the void space includes an upper cavity and a lower cavity, wherein the cross-sectional height and cross-sectional width of the lower cavity are smaller than those of the upper cavity.

41. A manifold box for use with a medical waste collection assembly, the manifold box comprising: A housing comprising a cover portion and an outer shell portion coupled to the cover portion to define a chamber, the outer shell portion including a distal base defining an outlet, the cover portion including a sleeve defining a void space in fluid communication with the chamber, and an inlet connector defining an aperture opening into the void space; and A tissue trap includes a screen defining a porous feature, the tissue trap being configured to be removably coupled to the housing, with the screen positioned within the void space for collecting tissue samples as fluid waste passes through the porous feature during operation of the medical waste collection assembly. The cannula is at least partially formed of a partially transparent material to allow the tissue trap to be seen when the tissue trap is positioned within the void space.

Images