Functional coating, intravascular stent and preparation method and application thereof

By loading antiproliferative drugs onto vascular stents through a β-peptide-polyester block copolymer coating, endothelial cell adhesion and proliferation are promoted, drug release is controlled, and the problems of delayed endothelialization and restenosis of vascular stents are solved, thus reducing the risk of thrombosis.

CN121695339APending Publication Date: 2026-03-20BROSMED MEDICAL CO LTD
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Patent Information

Application Number
CN202511983988.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-26
Publication Date
2026-03-20

AI Technical Summary

Technical Problem

Existing vascular stents inhibit smooth muscle cell proliferation and delay endothelial repair, increasing the risk of thrombosis. Furthermore, the lack of synergy between the inner and outer surfaces leads to a high restenosis rate.

Method used

A β-peptide-polyester block copolymer coating is used, in which amide bonds are formed by the reaction of β-peptide polymer with degradable polyester with NHS ester ends, loading antiproliferative drugs, promoting endothelial cell adhesion and proliferation, forming stable diffusion channels, and controlling drug release.

Benefits of technology

It achieves rapid adhesion and proliferation of vascular endothelial cells, effectively inhibits excessive proliferation of smooth muscle cells, reduces the risk of thrombosis and prevents restenosis, and improves treatment efficacy.

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Abstract

The invention discloses a functional coating, an intravascular stent and a preparation method and application of the intravascular stent. The functional coating comprises an endothelialization promoting active substance and an anti-proliferation drug; the endothelialization promoting active substance comprises at least one of polypeptide containing an RGD sequence, polypeptide containing a YIGSR sequence, polypeptide containing an REDV sequence, a beta-polypeptide polymer or a beta-polypeptide-polyester block copolymer. The functional coating disclosed by the invention can be used for surface functional modification of interventional medical devices, can selectively promote adhesion and proliferation of vascular endothelial cells at an implantation part, realizes rapid endothelialization, and can controllably release an anti-proliferation drug to inhibit excessive proliferation of vascular smooth muscle cells, so that the vascular endothelial cells are prevented from being damaged. Therefore, the risks of restenosis and advanced thrombus are effectively reduced.
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