A microsphere continuous production system

Abstract

The present application provides a kind of microsphere continuous production system, it includes the microsphere injection unit and the microsphere solidification unit connected;Microsphere injection unit has reactor and stirring injection device inserted in reactor, reactor is equipped with the partition that it is divided into upper chamber and lower chamber, stirring injection device has central shaft and the stirrer and dispersion disc connected in one end of central shaft, central shaft is inserted in reactor and stirrer and dispersion disc are located in lower chamber;Microsphere solidification unit is connected in the bottom outlet of reactor and has multiple solidification devices connected in sequence, each solidification device has solidification chamber, and each solidification chamber is sequentially connected in communication;Wherein, reactor is connected with the continuous phase injection device for injecting continuous phase into upper chamber, and continuous phase flows into lower chamber downward to drive the microsphere formed by dispersed phase injected through dispersion disc into microsphere solidification unit.The present application can solve the problems existing in the current microsphere production process, realize the continuous and efficient production of microsphere.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical manufacturing technology, and in particular to a continuous microsphere production system. Background Technology

[0002] Microspheres are spheres with a particle size in the micrometer range. In the field of drug delivery, drug-loaded microspheres refer to tiny spheres or spheroids formed by dissolving or dispersing drugs within polymer materials. The principle of drug loading in microspheres is to physically encapsulate or adsorb drugs onto or within the polymer surface. Microspheres can be classified according to their structure into porous microspheres, bilayer microspheres, and magnetic microspheres. Microsphere technology is mainly used in the pharmaceutical field for injectable and oral formulations.

[0003] Taste-masking technologies for oral medications include microparticle coating, macroporous resin adsorption, and microsphere technology. Among these, microparticle coating has several drawbacks: it is complex to operate; microparticles with a diameter of 300-1200 μm produce a poor taste (a strong gritty feel) when used to prepare dry suspensions; and because microparticle encapsulation is surface encapsulation (i.e., spraying and drying a coating solution onto the surface of API microparticles to achieve encapsulation), the API release rate in in vitro suspension preparations (pH 6.8) is between 0.5-2%, which is insufficient for masking the taste of extremely bitter APIs. As for resin adsorption technology, porous resins have adsorption properties in pharmaceutical production and are widely used in purification processes. However, due to their low adsorption rate (generally 5-20%) and resin content exceeding 80%, the high resin content in the medication can lead to side effects. Furthermore, the product is not perfectly spherical, resulting in poor flowability and potential uniformity issues when preparing compound formulations.

[0004] Currently, there is no complete set of standardized industrial equipment for microsphere preparation technology. The equipment used varies significantly depending on the specific microsphere technology being developed, resulting in numerous problems such as low microsphere sphericity, inconsistent microsphere size, low product yield, and low encapsulation efficiency. Industrialized equipment for microsphere preparation is currently a blank area in the pharmaceutical machinery market. Especially for continuous microsphere manufacturing, existing microsphere production equipment is mostly batch-based, requiring the completion of one batch before moving to the next. This inability to form a stable and continuous production line leads to inconsistent product quality within a single batch due to variations in curing time.

[0005] Chinese patent applications CN102512389A and CN1592622A use eutectic resin to fluidize drug-containing particles to form microspheres; Chinese patent application CN101822646A uses flavoring agents to mask the bitterness of drugs; Chinese patent application CN117503707A uses microsphere technology and eutectic resin carriers to solve the problem of masking the taste of fat-soluble and water-soluble bitter drugs, but it does not address the issues of microsphere injection methods (such as bottom injection, which can easily clog the injection needle or cause material to accumulate and become fluffy after long periods of continuous production), the uniformity of microsphere injection dispersion (the finished microspheres have poor particle size uniformity), and the solidification of microspheres. During the manufacturing process, several technical challenges arise, including partial "explosion" (leading to filtration difficulties), inconsistent microsphere solidification (newly injected microspheres and older microspheres mixed together in the reactor, resulting in equal probability of both being filtered during filtration; new microspheres, not fully solidified, "explode" under vacuum during filtration, affecting filtration speed; older microspheres, due to prolonged solidification time, cause dissolution of some raw materials and excipients, affecting microsphere encapsulation rate); and cumbersome microsphere filtration, pulping and washing, and manual discharge operations (repeated manual handling can easily cause product microbial and other quality problems). These challenges in the manufacturing of odor-masking microspheres urgently need to be addressed in continuous and large-scale mass production of microspheres. Summary of the Invention

[0006] The purpose of this invention is to provide a continuous microsphere production system that solves the problems existing in the current microsphere production process and achieves continuous and efficient microsphere production.

[0007] The above-mentioned technical objectives of the present invention are mainly achieved through the following technical solutions.

[0008] This invention provides a continuous microsphere production system, which includes a connected microsphere injection unit and a microsphere curing unit;

[0009] The microsphere injection unit has a reactor and a stirring injection device inserted into the reactor. The reactor is provided with a partition that divides its internal space into an upper chamber and a lower chamber. The stirring injection device has a central shaft and a stirrer and a dispersing disk connected to one end of the central shaft. The central shaft is inserted into the reactor and the stirrer and the dispersing disk are located in the lower chamber.

[0010] The microsphere curing unit is connected to the bottom outlet of the reactor. The microsphere curing unit has multiple curing devices connected in sequence. Each curing device has a curing chamber, and the curing chambers are connected in sequence.

[0011] The reactor is connected to a continuous phase injection device that injects a continuous phase into the upper chamber. The continuous phase flows downward into the lower chamber, thereby driving the microspheres formed by the dispersed phase injected through the dispersion disk into the microsphere solidification unit.

[0012] In a preferred embodiment of the present invention, the central shaft has a central fixed axis and a rotating shaft disposed outside the central fixed axis, and the stirrer and the dispersing disk are both connected to the rotating shaft.

[0013] In a preferred embodiment of the present invention, the rotating shaft has a stirring rotating shaft and a dispersing rotating shaft, the dispersing rotating shaft is sleeved outside the central fixed shaft, and the stirring rotating shaft is sleeved outside the dispersing rotating shaft; the stirrer is connected to the stirring rotating shaft, and the dispersing disc is connected to the dispersing rotating shaft.

[0014] In a preferred embodiment of the present invention, a central feed channel is provided within the central fixed axis, and the dispersion disk has a plurality of injection needles arranged in a scattering pattern. The inlet of each injection needle is connected to the central feed channel, and the outlet of each injection needle is arranged circumferentially outward.

[0015] In a preferred embodiment of the present invention, the dispersion disk further includes a protective disk, which is disposed on the dispersion shaft. The protective disk has a plurality of needle grooves arranged in a scattering pattern, and the injection needle is located in the needle grooves.

[0016] In a preferred embodiment of the present invention, the tip of the injection needle protrudes from the outer edge of the protective disc, and the protruding length of the injection needle is 1mm-10mm.

[0017] In a preferred embodiment of the present invention, the reactor has a truncated triangular structure, and the central axis is located at the center of the reactor.

[0018] In a preferred embodiment of the present invention, the volume of the lower chamber within the reactor is 0.5L-5L.

[0019] In a preferred embodiment of the present invention, the number of injection needles on the dispersion disk is 12-18.

[0020] In a preferred embodiment of the present invention, a gap is formed between the partition and the inner wall of the reactor, connecting the upper chamber and the lower chamber; the partition has a central hole and an exhaust hole, the central shaft passes through the central hole, and the exhaust hole is connected to a vacuum control valve through a pipe.

[0021] In a preferred embodiment of the present invention, the reactor is a truncated triangular structure, the partition is a triangular plate, and a triangular pyramidal brace is provided at each of the triangular parts of the partition. One side of the triangular pyramidal brace is connected to the lower side of the partition, and the other two sides are respectively abutted against the two inner sides of the reactor. The bottom surface of the triangular pyramidal brace is inclined relative to the bottom surface of the reactor to form an inclined surface that guides the microspheres to flow downward.

[0022] In a preferred embodiment of the present invention, the curing device is a curing glass ball, and a spherical curing chamber is formed inside the curing glass ball. Each of the curing glass balls is connected in sequence through a connecting pipe so that each of the spherical curing chambers is connected.

[0023] In a preferred embodiment of the present invention, the cured glass sphere is provided with a magnetic rotor, and the cured glass sphere is disposed on a magnetic stirrer having a magnetic stirrer capable of driving the magnetic rotor to rotate.

[0024] In a preferred embodiment of the present invention, each of the cured glass spheres is connected to an exhaust pipe that communicates with the spherical curing chamber, and the exhaust pipe is provided with an exhaust valve.

[0025] In a preferred embodiment of the present invention, along the continuous curing direction of the microspheres, the height of each of the cured glass spheres decreases sequentially, so that the microsphere curing unit is at an elevation angle of 8°-15°.

[0026] In a preferred embodiment of the present invention, the number of the cured glass spheres is 6-8; and / or the volume of the spherical curing chamber is 250mL-500mL.

[0027] In a preferred embodiment of the present invention, the microsphere continuous production system further includes a dissolution and preparation unit and a metering and dosing unit; the dissolution and preparation unit has a dissolution tank and a dissolution stirring paddle disposed in the dissolution tank, the outlet of the dissolution tank is connected to a stirring and feeding device through a pipeline, and the metering and dosing unit has a metering pump disposed on the pipeline.

[0028] In a preferred embodiment of the present invention, the microsphere continuous production system further includes a filtration and washing discharge unit. The inlet of the filtration and washing discharge unit is connected to the outlet of the microsphere solidification unit. The filtration and washing discharge unit has a cleaning filter box. The bottom of the cleaning filter box has a filter screen and is connected to a liquid outlet channel. A washing and stirring paddle for spraying cleaning liquid is inserted inside the cleaning filter box.

[0029] In a preferred embodiment of the present invention, the cleaning filter box has a separable filter barrel and a base, the filter screen and the liquid outlet channel are disposed on the base, and the base is connected to a filter barrel opening and closing cylinder that drives its lifting and lowering; the filtration washing discharge unit also has a pushing mechanism.

[0030] With the base raised and docked with the filter barrel, the microsphere suspension entering the cleaning filter box is cleaned and filtered.

[0031] With the base lowered and separated from the filter barrel, the microspheres cleaned and filtered on the filter screen are pushed out by the pushing mechanism to achieve material discharge.

[0032] Compared with the prior art, the technical solution of the present invention has the following characteristics and advantages:

[0033] The microsphere continuous production system of the present invention is designed with a central shaft and a dispersion disk for injecting the dispersed phase into the continuous phase, thereby realizing the axial injection of the dispersed phase and solving the problem of needle clogging and interruption of the injection needle during the production process.

[0034] The microsphere continuous production system of the present invention has a dispersion disk with multiple injection needles and a protective disk, which solves the problems of uniform microsphere dispersion and uniform particle size, while avoiding the problem of microsphere damage during injection needle rotation.

[0035] The microsphere continuous production system of the present invention has a microsphere curing unit with multiple curing glass spheres connected in sequence, thereby realizing the gradient curing of microspheres and solving the problem of low encapsulation rate during the microsphere curing process.

[0036] The microsphere continuous production system of the present invention is designed with a filtration, washing and discharge unit, which realizes the filtration, washing and discharge of microspheres through integrated equipment, thereby improving product quality and production efficiency. Attached Figure Description

[0037] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. In the drawings:

[0038] The accompanying drawings described herein are for illustrative purposes only and are not intended to limit the scope of the invention in any way. Furthermore, the shapes and proportions of the components in the drawings are merely illustrative to aid in understanding the invention and do not specifically limit the shapes and proportions of the components. Those skilled in the art, guided by the teachings of this invention, can select various possible shapes and proportions to implement the invention according to specific circumstances.

[0039] Figure 1 This is a schematic diagram of the microsphere continuous production system described in this invention;

[0040] Figure 2 This is a schematic diagram of the structure of the reactor described in this invention;

[0041] Figure 3 This is a schematic diagram of the structure of the central shaft described in this invention;

[0042] Figure 4 This is a side view of the dispersion disk described in this invention.

[0043] Figure 5 This is a bottom view of the structure of the dispersion disk described in this invention;

[0044] Figure 6 This is a schematic diagram of the structure of the partition described in this invention;

[0045] Figure 7 This is a schematic diagram of the structure of the microsphere curing unit described in this invention;

[0046] Figure 8 This refers to the filtration and washing discharge unit described in this invention.

[0047] Explanation of reference numerals in the attached figures:

[0048] 100. Dissolving and preparation unit; 101. Dissolving and preparation tank; 102. Dissolving and preparation stirring paddle;

[0049] 200. Metering and dosing unit; 201. Metering pump;

[0050] 300. Microsphere injection unit; 310. Reactor; 311. Upper chamber; 312. Lower chamber; 320. Stirring and injection device; 321. Central shaft; 322. Central fixed shaft; 3221. Central feed channel; 323. Stirring shaft; 324. Dispersion shaft; 325. Stirrer; 326. Dispersion disc; 327. Injection needle; 328. Protective disc; 330. Baffle; 331. Central hole; 332. Vent hole; 333. Vent hole connector; 334. Stirrer trajectory; 335. Baffle connection area; 336. Triangular pyramidal brace; 337. Inclined surface;

[0051] 400. Microsphere curing unit; 401. Curing glass sphere; 402. Spherical curing chamber; 403. Magnetic rotor; 404. Magnetic stirrer; 405. Exhaust pipe; 406. Exhaust valve; 407. Connecting pipe;

[0052] 500. Filter washing discharge unit; 501. Filter barrel; 502. Base; 503. Feed inlet; 504. Cleaning liquid inlet; 505. Washing agitator; 506. Washing agitator lifting cylinder; 507. Washing liquid outlet; 508. Sealing ring; 509. Liquid outlet channel; 510. Drain outlet; 511. Filter barrel opening and closing cylinder; 512. Pushing scraper; 513. Pushing cylinder; 514. Filter screen. Detailed Implementation

[0053] To enable those skilled in the art to better understand the technical solutions of this invention, the technical solutions of the embodiments of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this invention.

[0054] It should be noted that when an element is referred to as being "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only embodiments.

[0055] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the specification of this invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0056] This invention provides a continuous microsphere production system, such as... Figures 1 to 6As shown, it includes a connected microsphere injection unit 300 and a microsphere curing unit 400; the microsphere injection unit 300 has a reactor 310 and a stirring injection device 320 inserted into the reactor 310. The reactor 310 is provided with a partition 330 that divides its internal space into an upper chamber 311 and a lower chamber 312. The stirring injection device 320 has a central shaft 321 and a stirrer 325 and a dispersion disk 326 connected to one end of the central shaft 321. The central shaft 321 is inserted into the reactor 310 and the stirrer 325... The dispersion disk 326 is located in the lower chamber 312; the microsphere curing unit 400 is connected to the bottom outlet of the reactor 310. The microsphere curing unit 400 has multiple curing devices connected in sequence, each curing device has a curing chamber, and the curing chambers are connected in sequence; wherein, the reactor 310 is connected to a continuous phase injection device for injecting a continuous phase into the upper chamber 311, and the continuous phase flows downward into the lower chamber 312 to drive the microspheres formed by the dispersed phase injected through the dispersion disk 326 into the microsphere curing unit 400.

[0057] The microsphere continuous production system of the present invention is designed with a central shaft 321 and a dispersion disk 326 for injecting the dispersed phase into the continuous phase, thereby realizing the axial dispersion injection of the dispersed phase and solving the problem of needle clogging and interruption of the injection needle 327 during the production process.

[0058] The microsphere continuous production system of the present invention has a microsphere curing unit 400 with multiple curing glass spheres 401 connected in sequence, thereby realizing the gradient curing of microspheres and solving the problem of low encapsulation rate during the microsphere curing process.

[0059] The microsphere continuous production system of the present invention achieves continuous industrial production of microspheres through the synergistic effect of the microsphere injection unit 300 and the microsphere curing unit 400, overcomes the problem of "explosion" that is easy to occur in the current continuous production process of microspheres, and greatly improves the level of industrial preparation of microspheres.

[0060] The following section will provide a detailed description of the specific structure of each part of the microsphere continuous production system described in this invention, as well as the connection relationships between each part.

[0061] The microsphere continuous production system has a microsphere injection unit 300, which is used to inject a dispersed phase (a mixture of organic solvent and water) into a continuous phase (e.g., water) to initially produce a microsphere suspension containing microspheres.

[0062] The microsphere injection unit 300 includes a reactor 310, which is the main body of the microsphere injection unit 300. The entire reaction process takes place within the reactor 310. Specifically, as... Figure 1 and Figure 2As shown, in this embodiment, the reactor 310 is an inverted vertical truncated triangular structure with a reaction chamber inside, and a microsphere suspension outlet at the bottom of the reaction chamber; the shape of the reactor 310 can be set according to actual needs and is not limited to a truncated triangular structure.

[0063] Preferably, in order to improve production efficiency, multiple reactors 310 can be connected in parallel within the microsphere injection unit 300, and each reactor 310 can operate independently and produce microsphere suspension.

[0064] Preferably, the volume of the lower chamber 312 in the reactor 310 is 0.5L-5L. By reasonably setting the volume of the lower chamber 312, the consistency of microsphere solidification, the synchronization of microspheres, the uniformity of microspheres, the economy of microspheres and the production capacity of microspheres in the microsphere reaction can be balanced.

[0065] The microsphere injection unit 300 also has a baffle 330 disposed within the reactor 310. The baffle 330 is used to separate the internal space of the reactor 310, so that the microspheres initially generated during the injection reaction are all confined below the baffle 330, thereby preventing the microspheres from floating to the liquid surface and causing "explosion". Specifically, such as Figure 1 , Figure 2 and Figure 6 As shown, the shape of the partition 330 is the same as the cross-sectional shape of the reactor 310. In this embodiment, the partition 330 is triangular. The partition 330 is arranged parallel to the bottom and top surfaces of the reactor 310, thereby dividing the reaction chamber into an upper chamber 311 and a lower chamber 312. A gap is formed between the partition 330 and the inner wall of the reactor 310. The upper chamber 311 and the lower chamber 312 are connected through the gap. By controlling the width of the gap, it is ensured that the microspheres cannot pass through, while ensuring that the continuous phase in the upper chamber 311 can smoothly enter the lower chamber 312.

[0066] The microsphere injection unit 300 also has a continuous phase injection device (not shown) connected to the reactor 310. The continuous phase injection device is connected to the upper chamber 311 via a pipe. Inside the reactor 310, the injected continuous phase flows from top to bottom, flowing from the upper chamber 311 through the baffle 330 into the lower chamber 312, and carrying the microspheres generated in the lower chamber 312 through the injection, flowing out of the reactor 310 from the bottom outlet. The upper liquid level in the upper chamber 311 can effectively buffer the differential fluctuations in the feed rate and discharge rate during production.

[0067] The microsphere injection unit 300 also has a stirring injection device 320 inserted into the reactor 310, which is used to inject the dispersed phase and stir the microsphere suspension in the lower chamber 312.

[0068] Specifically, such as Figure 1As shown, the stirring and feeding device 320 has a central shaft 321 that is inserted downwards into the reaction chamber from the top of the reactor 310; as Figure 6 As shown, the partition plate 330 has a central hole 331 through which the central shaft 321 passes. The central shaft 321 is located at the axis of the reactor 310 and coincides with the central axis of the truncated triangular prism.

[0069] like Figures 3 to 5 As shown, the central shaft 321 has a central fixed shaft 322 and a stirring shaft 323 and a dispersing shaft 324 disposed outside the central fixed shaft 322. The dispersing shaft 324 is sleeved on the central fixed shaft 322, the stirring shaft 323 is sleeved on the dispersing shaft 324, the stirrer 325 is connected to the stirring shaft 323, and the dispersing disc 326 is connected to the dispersing shaft 324.

[0070] The drive device on the microsphere injection unit 300 can drive the dispersion shaft 324 and the stirring shaft 323 to rotate respectively, thereby driving the dispersion disk 326 and the stirrer 325 to rotate. Compared with the embodiment where the dispersion disk 326 and the stirrer 325 are on the same shaft, the triaxial injection method can realize differential speed control of the stirrer 325 and the dispersion disk 326.

[0071] The central fixed axis 322 is provided with a central feed channel 3221, and the dispersion disk 326 has multiple injection needles 327 arranged in a scattering pattern. The inlet of each injection needle 327 is connected to the central feed channel 3221, and the outlet of each injection needle 327 is arranged circumferentially outward.

[0072] By using an axial center feeding method, compared to the existing technology of single or multiple point dripping at the top or bottom of the liquid surface, the microspheres in this invention exhibit better sphericity and uniformity.

[0073] Furthermore, such as Figure 4 and Figure 5 As shown, the dispersion disk 326 also has a protective disk 328, which is mounted on the dispersion shaft 324. The protective disk 328 has multiple needle grooves arranged in a scattering pattern, and the injection needle 327 is located in the needle grooves. By setting the protective disk 328, the injection needle 327 is hidden in the needle grooves, thereby avoiding the problem of the injection needle 327 damaging the microspheres during rotation.

[0074] Better, such as Figure 5 As shown, the tip of the injection needle 327 protrudes from the outer edge of the protective plate 328, and the protrusion length of the injection needle 327 is 1mm-10mm.

[0075] Preferably, the dispersion disk 326 is provided with 1-100 injection needles 327, the inner diameter of the injection needles 327 being 0.5mm-3mm.

[0076] Preferably, the dispersion disc 326 can be configured with 2 needles, 4 needles, 6 needles, 12 needles, 18 needles, 24 needles and 48 needles, and the inner diameter of the injection needle 327 is 0.7mm-2.0mm.

[0077] Preferably, the dispersion disc 326 can be configured with 6 needles, 12 needles, 18 needles, or 24 needles, and the inner diameter of the injection needle 327 is 0.8mm-1.6mm.

[0078] More preferably, the dispersion disk 326 can be selected with 12 or 18 needles, and the inner diameter of the injection needle 327 is 1.0 mm-1.2 mm.

[0079] The microsphere continuous production system has a microsphere solidification unit 400, which is connected to the microsphere injection unit 300 and is used to solidify the microspheres in the microsphere suspension produced by the unit.

[0080] like Figure 1 and Figure 7 As shown, the microsphere curing unit 400 has multiple curing devices connected in sequence. Each curing device is a curing glass sphere 401, and a spherical curing chamber 402 is formed within each sphere. The curing glass spheres 401 are connected in sequence via connecting pipes 407, allowing the spherical curing chambers 402 to communicate with each other. Compared to other materials (such as stainless steel, polymer materials, etc.), glass provides good transparency for observing the curing effect.

[0081] Furthermore, such as Figure 7 As shown, a magnetic rotor 403 is provided inside the curing glass ball 401, and the curing glass ball 401 is mounted on a magnetic stirrer 404 that can drive the magnetic rotor 403 to rotate.

[0082] Furthermore, such as Figure 7 As shown, each of the cured glass spheres 401 is connected to an exhaust pipe 405 that communicates with the spherical curing chamber 402, and an exhaust valve 406 is provided on the exhaust pipe 405.

[0083] Furthermore, such as Figure 7 As shown, along the continuous curing direction of the microspheres, the height of each cured glass sphere 401 decreases sequentially, so that the microsphere curing unit 400 is at an elevation angle of 0-60°, preferably 10-30°, and more preferably 8-15°.

[0084] Preferably, the number of cured glass beads 401 is 1-50, more preferably 3-20, and even more preferably 5-10.

[0085] Preferably, the volume of the spherical curing chamber 402 is 25mL-3000mL, more preferably 250-1000mL, and even more preferably 250mL-500mL.

[0086] By rationally controlling the elevation angle, number, and volume of the curing glass spheres, the continuous curing process of the microspheres can be controlled, ensuring the effectiveness of continuous curing.

[0087] The following will further explain the structure and technical effects of the preferred embodiment of the microsphere continuous production system of the present invention.

[0088] According to one embodiment of the present invention, such as Figure 6 As shown, the partition 330 has vent holes 332, which are connected to the vacuum control valve via pipes. There are 6-9 vent holes 332, which are connected in parallel via vent hole connectors 333 and connected to the vacuum control valve to extract bubbles generated during the injection reaction process (the bubbles will converge on the lower side of the partition 330).

[0089] According to one embodiment of the present invention, such as Figure 2 and Figure 6 As shown, each of the triangular parts of the partition 330 is provided with a triangular pyramidal brace 336. One side of the triangular pyramidal brace 336 is connected to the lower side of the partition 330 and can be connected to the partition connection area 335 by screws. The other two sides abut against the two inner sides of the reactor 310 respectively. The bottom surface of the triangular pyramidal brace 336 is inclined relative to the bottom surface of the reactor 310 to form an inclined surface 337 that guides the microspheres to flow downward.

[0090] like Figure 6 As shown, the effective plane of the lower part of the partition 330 is hexagonal through three triangular pyramidal braces, which is adapted to the stirrer trajectory 334, minimizing the stirring dead angle and preventing microspheres from accumulating. At the same time, the bottom surface of the triangular pyramidal braces 336 guides the microspheres to flow downward, ensuring that the microsphere suspension in the lower chamber 312 can carry the microspheres smoothly from the bottom outlet into the microsphere solidification unit 400.

[0091] According to one embodiment of the present invention, such as Figure 1 As shown, the microsphere continuous production system also includes a dissolution and preparation unit 100 and a metering and dosing unit 200; the dissolution and preparation unit 100 is used for preparing the dispersed phase, and the metering and dosing unit 200 is used for controlling the injection amount of the dispersed phase (the injection rate into the reactor 310).

[0092] The dissolution preparation unit 100 has a dissolution tank 101 and a dissolution stirring paddle 102 disposed in the dissolution tank 101. The outlet of the dissolution tank 101 is connected to the stirring and feeding device 320 through a pipeline. The metering and dosing unit 200 has a metering pump 201 disposed on the pipeline.

[0093] According to one embodiment of the present invention, such as Figure 1 and Figure 8As shown, the microsphere continuous production system also includes a filtration and washing discharge unit 500. The inlet 503 of the filtration and washing discharge unit 500 is connected to the outlet of the microsphere curing unit 400. The filtration and washing discharge unit 500 has a cleaning filter box, and the inlet 503 is located on the filter barrel 501 of the cleaning filter box.

[0094] The bottom of the cleaning filter box has a filter screen 514 and a liquid outlet channel 509, the end of which forms a drain port 510. A washing agitator 505 for spraying cleaning fluid is inserted inside the cleaning filter box. The washing agitator 505 is connected to a washing agitator lifting cylinder 506 that drives its lifting and lowering. The washing agitator 505 has a washing fluid outlet hole 507, and the top of the washing agitator 505 has a cleaning fluid inlet 504 for connecting to a cleaning fluid supply pipe.

[0095] The filter screen 514 can be made of titanium alloy sintered plate, stainless steel mesh, nylon mesh or filter cloth. The diameter of the filter screen 514 can be selected from 10cm to 50cm, and the pore size on the filter screen 514 can be selected from 30μm to 120μm. The washing and stirring lifting cylinder 506 is used to move the washing and stirring paddle 505 up and down. The hollow shaft on the washing and stirring paddle 505 and the rotation of the washing and stirring paddle 505 are used to complete the addition of washing liquid and stirring and washing.

[0096] Preferably, the filter screen 514 can be made of titanium alloy sintered plate, stainless steel mesh and filter cloth, the diameter of the filter screen 514 can be selected from 15cm to 40cm, and the pore size of the filter screen 514 can be selected from 40μm to 70μm.

[0097] More preferably, the microsphere filter 514 can be made of titanium alloy sintered plate or stainless steel mesh, the diameter of the filter 514 can be selected from 20cm to 30cm, and the pore size of the filter 514 can be selected from 50μm to 60μm.

[0098] Furthermore, such as Figure 8 As shown, the cleaning filter box has a separable filter barrel 501 and a base 502, and a sealing ring 508 is provided between the bottom annular surface of the filter barrel 501 and the base 502. The filter screen 514 and the liquid outlet channel 509 are provided on the base 502, and the base 502 is connected to a filter barrel opening and closing cylinder 511 that drives its lifting and lowering; the filter washing discharge unit 500 also has a pushing mechanism, which has a pushing cylinder 513 and a pushing scraper 512 connected to the pushing cylinder 513. The pushing cylinder 513 is provided on the base 502 and located on one side of the base 502, and the pushing cylinder 513 can drive the pushing scraper 512 to move.

[0099] With the base 502 raised and aligned with the filter tank 501, the microsphere suspension entering the cleaning filter box is cleaned and filtered; with the base 502 lowered and separated from the filter tank 501, as... Figure 8As shown, the microspheres after cleaning and filtration on the filter screen 514 are pushed out by the pushing mechanism to achieve material discharge.

[0100] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A continuous microsphere production system, characterized in that, It includes a connected microsphere injection unit (300) and a microsphere curing unit (400). The microsphere injection unit (300) has a reactor (310) and a stirring injection device (320) inserted into the reactor (310). The reactor (310) is provided with a partition (330) that divides its internal space into an upper chamber (311) and a lower chamber (312). The stirring injection device (320) has a central shaft (321) and a stirrer (325) and a dispersing disk (326) connected to one end of the central shaft (321). The central shaft (321) is inserted into the reactor (310) and the stirrer (325) and the dispersing disk (326) are located in the lower chamber (312). The microsphere curing unit (400) is connected to the bottom outlet of the reactor (310). The microsphere curing unit (400) has a plurality of curing devices connected in sequence. Each curing device has a curing chamber, and the curing chambers are connected in sequence. The reactor (310) is connected to a continuous phase injection device that injects a continuous phase into the upper chamber (311). The continuous phase flows downward into the lower chamber (312) to drive the microspheres formed by the dispersed phase injected through the dispersion disk (326) into the microsphere solidification unit (400). The central shaft (321) has a central fixed shaft (322) and a rotating shaft located outside the central fixed shaft (322), and the stirrer (325) and the dispersing disk (326) are both connected to the rotating shaft; The rotating shaft has a stirring shaft (323) and a dispersing shaft (324). The dispersing shaft (324) is sleeved outside the central fixed shaft (322), and the stirring shaft (323) is sleeved outside the dispersing shaft (324). The stirrer (325) is connected to the stirring shaft (323), and the dispersing disc (326) is connected to the dispersing shaft (324). The central fixed axis (322) is provided with a central feed channel (3221), and the dispersion disk (326) has a plurality of injection needles (327) arranged in a scattering pattern. The inlet of each injection needle (327) is connected to the central feed channel (3221), and the outlet of each injection needle (327) is arranged circumferentially outward.

2. The microsphere continuous production system according to claim 1, characterized in that, The dispersion disk (326) also has a protective disk (328), which is disposed on the dispersion shaft (324). The protective disk (328) has a plurality of needle grooves arranged in a scattering pattern, and the injection needle (327) is located in the needle grooves.

3. The microsphere continuous production system according to claim 2, characterized in that, The tip of the injection needle (327) protrudes from the outer edge of the protective disc (328), and the protrusion length of the injection needle (327) is 1mm-10mm.

4. The microsphere continuous production system according to any one of claims 1-3, characterized in that, The reactor (310) has a triangular truncated pyramid structure, and the central axis (321) is located at the center of the reactor (310).

5. The microsphere continuous production system according to claim 2, characterized in that, The volume of the lower chamber (312) within the reactor (310) is 0.5L-5L; And / or, the number of injection needles (327) on the dispersion disk (326) is 12-18.

6. The microsphere continuous production system according to claim 1, characterized in that, A gap is formed between the partition (330) and the inner wall of the reactor (310) to connect the upper chamber (311) and the lower chamber (312); the partition (330) is provided with a central hole (331) and an exhaust hole (332), the central shaft (321) passes through the central hole (331), and the exhaust hole (332) is connected to the vacuum control valve through a pipe.

7. The microsphere continuous production system according to claim 6, characterized in that, The reactor (310) has a triangular truncated pyramid structure, and the partition (330) is a triangular plate. Each of the triangular parts of the partition (330) is provided with a triangular pyramidal brace (336). One side of the triangular pyramidal brace (336) is connected to the lower side of the partition (330), and the other two sides are respectively abutted against the two sides of the reactor (310). The bottom surface of the triangular pyramidal brace (336) is inclined relative to the bottom surface of the reactor (310) to form an inclined surface (337) that guides the microspheres to flow downward.

8. The microsphere continuous production system according to claim 1, characterized in that, The curing device is a curing glass ball (401), and a spherical curing chamber (402) is formed inside the curing glass ball (401). Each of the curing glass balls (401) is connected in sequence through a connecting pipe (407) so that each of the spherical curing chambers (402) is connected.

9. The microsphere continuous production system according to claim 8, characterized in that, The curing glass ball (401) is provided with a magnetic rotor (403), and the curing glass ball (401) is mounted on a magnetic stirrer (404) that can drive the magnetic rotor (403) to rotate.

10. The microsphere continuous production system according to claim 8, characterized in that, Each of the cured glass spheres (401) is connected to an exhaust pipe (405) that communicates with the spherical curing chamber (402), and an exhaust valve (406) is provided on the exhaust pipe (405). And / or, along the continuous curing direction of the microspheres, the setting height of each of the cured glass spheres (401) decreases sequentially, so that the microsphere curing unit (400) is at an elevation angle of 8°-15°; And / or, the number of the cured glass spheres (401) is 6-8; and / or, the volume of the spherical curing chamber (402) is 250mL-500mL.

11. The microsphere continuous production system according to claim 1, characterized in that, The microsphere continuous production system further includes a dissolution and preparation unit (100) and a metering and dosing unit (200); the dissolution and preparation unit (100) has a dissolution tank (101) and a dissolution stirring paddle (102) disposed in the dissolution tank (101), the outlet of the dissolution tank (101) is connected to the stirring and feeding device (320) through a pipeline, and the metering and dosing unit (200) has a metering pump (201) disposed on the pipeline.

12. The microsphere continuous production system according to claim 1 or 11, characterized in that, The microsphere continuous production system also includes a filtration and washing discharge unit (500). The inlet (503) of the filtration and washing discharge unit (500) is connected to the outlet of the microsphere solidification unit (400). The filtration and washing discharge unit (500) has a cleaning filter box. The bottom of the cleaning filter box has a filter screen (514) and is connected to a liquid outlet channel (509). A washing agitator (505) for spraying cleaning liquid is inserted in the cleaning filter box.

13. The microsphere continuous production system according to claim 12, characterized in that, The cleaning filter box has a separable filter barrel (501) and a base (502). The filter screen (514) and the liquid outlet channel (509) are located on the base (502). The base (502) is connected to a filter barrel opening and closing cylinder (511) that drives its lifting and lowering. The filter washing discharge unit (500) also has a pushing mechanism. With the base (502) raised and docked with the filter barrel (501), the microsphere suspension entering the cleaning filter box is cleaned and filtered. With the base (502) lowered and separated from the filter barrel (501), the microspheres that have been cleaned and filtered on the filter screen (514) are pushed out by the pushing mechanism to achieve material discharge.

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