Eye protection liquid for preventing and controlling eyesight and preparation method thereof

Abstract

The invention relates to the technical field of eye protection liquid, and particularly discloses vision prevention and control eye protection liquid and a preparation method thereof.The vision prevention and control eye protection liquid is prepared from deionized water, propylene glycol, sodium hyaluronate, protection extract, antibacterial and anti-inflammatory ionic liquid, vitamin B6, taurine, witch hazel distillate, dipotassium glycyrrhizinate, borneol, menthol, E1004 and moisturizing polysaccharide; all the components in the eyesight prevention and control eye protection liquid take effect synergistically, the eyesight prevention and control eye protection liquid can moisten eyes for a long time and reduce tear evaporation while effectively resisting inflammation and relieving, eyestrain is relieved by adjusting ciliary muscle metabolism, and occurrence and development of myopia are prevented in an auxiliary mode through the retina protection effect.

Description

Technical Field

[0001] This invention relates to the field of eye care technology, specifically to a vision control eye care solution and its preparation method. Background Technology

[0002] Current vision control products generally suffer from problems such as single ingredients and limited target sites. From the perspective of ocular surface physiology, the hydrophobic barrier of the tear film lipid layer and the tight junctions between corneal epithelial cells together constitute a natural defense against exogenous substances. This structural characteristic places extremely high demands on the delivery of active ingredients in control products. Traditional products, lacking efficient delivery systems adapted to ocular surface physiology, often leave active ingredients stuck on the tear film surface, only able to act on the ocular surface mucosa, unable to penetrate the corneal barrier to reach the choroid, retina, and other core target tissues for vision regulation. This results in minimal intervention effects on deeper problems such as retinal light damage and optic nerve fatigue.

[0003] At the level of ingredient design and preparation, existing products also have significant shortcomings: most formulas are based on single vitamins (such as vitamin B6) or cooling agents (such as borneol), which can only provide basic nutritional supplementation or immediate comfort enhancement, lacking targeted intervention on the mechanisms of vision damage; although some products have attempted to add plant-based active ingredients, the extraction rate of core active ingredients such as fat-soluble tea polyphenol esters and flavonoid glycosides in the preparation of plant raw materials is insufficient, resulting in low content of effective ingredients in the products; more importantly, vision damage and myopia progression are the result of the synergistic effects of multiple factors such as oxidative damage (blue light-induced accumulation of reactive oxygen species), release of inflammatory factors (IL-6, TNF-α), and ciliary muscle spasm, while existing products mostly focus on a single pathological link, lacking a full-chain intervention system of "ocular surface protection - inflammation suppression - neuroprotection - accommodative spasm". This "single-point action" model is seriously out of touch with the complex needs of vision control, becoming a core technical bottleneck restricting the upgrading of product efficacy, and urgently requires the development of a new vision control solution with synergistic ingredients, efficient delivery, and comprehensive targets. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a vision control eye protection liquid and its preparation method, which solves the problems in the prior art through an innovative combination of "natural extract compound + neuromodulator + antioxidant matrix".

[0005] This invention solves the above-mentioned technical problems and provides a vision protection eye drop, comprising the following components by weight: deionized water, propylene glycol, sodium hyaluronate, protective extract, antibacterial and anti-inflammatory ionic liquid, vitamin B6, taurine, witch hazel distillate, dipotassium glycyrrhizate, borneol, menthol, E1004, and moisturizing polysaccharide. The aforementioned vision protection eye drop comprises the following components by weight: 65-90 parts deionized water, 2-5 parts propylene glycol, 0.01-0.1 parts sodium hyaluronate, 1-3 parts protective extract, 1-3 parts antibacterial ionic liquid, 0.1-1 parts vitamin B6, 0.1-1 parts taurine, 0.2-1 parts witch hazel distillate, 0.01-0.1 parts dipotassium glycyrrhizate, 0.1-0.3 parts borneol, 0.02-0.1 parts menthol, 0.5-1 parts E1004, and 1-3 parts moisturizing polysaccharide. Taurine promotes the synthesis of γ-aminobutyric acid (GABA), regulates optic nerve signal transmission, and relieves ciliary muscle spasm; Vitamin B6 (pyridoxine hydrochloride) catalyzes the conversion of glutamate to GABA, blocks neuroexcitotoxicity, and synergistically enhances neuroprotection with taurine. Witch hazel distillate and tannins enhance vascular tone, improve permeability of capillaries around the eyes, and eliminate metabolic stagnation; menthol and borneol activate TRPM8 cold receptors, instantly increasing local blood flow by more than 30%. Hyaluronic acid (HA) and propylene glycol form a three-dimensional moisturizing network to enhance the hydration of corneal epithelial cells; dipotassium glycyrrhizate inhibits MMP-9 metalloproteinase and repairs tight junction protein damage caused by blue light. The protective extract is prepared by pulverizing a mixture of plant materials, including chrysanthemum, green tea, eucommia leaves, and hibiscus flowers, and then subjecting them to high-pressure cell disruption for 3-5 minutes at a pressure of 0.01-0.03 MPa. The disrupted material is then extracted in an extraction vessel. After extraction, the fat-soluble extract is collected, and 7-10 times the volume of water is added. The extract is then ultrasonically extracted at an ultrasonic frequency of 20-30 kHz for 2-3 hours to obtain a water-soluble extract. The fat-soluble extract and the water-soluble extract are combined, microfiltered, and then compressed and dried under reduced pressure to obtain the final product. The extraction conditions are as follows: using food-grade ethanol at a concentration of 8-12% of the raw material mass as an entrainer, controlling the extraction pressure at 28-32 MPa, the extraction temperature at 40-45℃, the CO2 flow rate at 25 L / h, and the extraction time at 100-120 min. The mass ratio of chrysanthemum, green tea, eucommia leaves and hibiscus flowers in the mixed plant materials is (5-15):(1-10):(3-5):(2-8). Green tea contains highly active tea polyphenols (EGCG), which target and scavenge free radicals and inhibit blue light-induced oxidative damage to retinal pigment epithelial cells; chrysanthemum contains flavonoids such as luteolin, which specifically inhibit the COX-2 inflammatory pathway and reduce the expression of corneal inflammatory factor TNF-α; chrysanthemum and green tea, as basic eye-protecting ingredients, provide broad-spectrum antioxidant effects, while eucommia leaves enhance the anti-inflammatory effect, and hibiscus flowers enhance retinal protection with highly active anthocyanins; The antibacterial ionic liquid is prepared by grinding 0.05-0.15 parts of ellagic acid and 0.03-0.10 parts of oat β-glucan into a composite powder, adding 4-6 parts of deionized water, and then adding 0.2-0.5 parts of nano silver ion liquid (concentration of 1000ppm) dropwise while stirring. The silver ions form coordination bonds with the functional groups of ellagic acid and are simultaneously encapsulated by oat β-glucan colloid, reducing the chemical activity of the silver ions and improving biocompatibility and stability. The particle size of the composite powder is 2-4 μm; The moisturizing polysaccharide is zinc hyaluronic acid and yeast β-glucan in a mass ratio of 1:1-3. The moisturizing polysaccharide stabilizes the antibacterial activity of silver ions and reduces safety risks. The hydroxyl groups (-OH) of yeast β-glucan form a hydrogen bond network with tea polyphenols and anthocyanins in the extract, which improves the stability of active ingredients. The antioxidant activity of zinc ions in zinc hyaluronic acid prevents the extract from oxidizing, discoloring, and losing its activity.

[0006] This invention also provides a method for preparing vision protection eye drops, comprising the following steps: Step 1: Mix and dissolve 1 / 3 propylene glycol and E1004 completely to obtain mixture A; mix and dissolve 1 / 3 propylene glycol, borneol and menthol completely to obtain mixture B; mix and dissolve 1 / 4 deionized water, vitamin B6, taurine and protective extract completely to obtain mixture C; mix and dissolve 1 / 4 deionized water and dipotassium glycyrrhizate completely to obtain mixture D. Step 2: Add 1 / 4 of the deionized water and sodium hyaluronate to the emulsification pot, stir and heat to 85℃ to dissolve, and keep warm for 25-35 minutes; Step 3: After cooling, add mixture A while stirring; cool to 40℃ and add mixtures B, C, and D, and the remaining components respectively; The cooling temperature is 40-45℃; Step 4: Test viscosity and pH, then filter the material through a 100-mesh filter cloth.

[0007] The beneficial effects of this invention are as follows: The vision protection eye drop provided by this invention contains chrysanthemum (anti-inflammatory), green tea (antioxidant), eucommia leaf (regulates inflammatory pathways and provides neuroprotection), and hibiscus flower (retinal protection and promotes ocular blood circulation) in the added protective extracts, which work synergistically to protect vision; the added antibacterial ionic liquid grinds ellagic acid and oat β-glucan, exposing more functional groups, allowing ellagic acid to coordinate with silver ions through multidentate structures, and the colloidal encapsulation effect of oat β-glucan, thereby improving the antibacterial stability of silver ions while reducing... Silver ion dependence; the moisturizing polysaccharide contains zinc hyaluronic acid with strong water-locking ability, and yeast β-glucan has a long-lasting effect due to its mucosal adhesion; witch hazel distillate (containing tannic acid) and dipotassium glycyrrhizate work synergistically to soothe; E1004 and moisturizing polysaccharides work synergistically to regulate viscosity, which is consistent with the characteristics of tears; the components in the vision control eye drops work synergistically to effectively reduce inflammation and soothe the eyes, while also providing long-lasting hydration, reducing tear evaporation, relieving eye fatigue by regulating ciliary muscle metabolism, and assisting in the prevention of myopia development through retinal protection.

[0008] The preparation method of the vision control eye protection solution provided by this invention uses a phase separation dissolution process to avoid the stratification problem of lipid-soluble and water-soluble substances. Detailed Implementation

[0009] The present invention will be further described in detail below through specific implementation examples. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of protection of the present invention. After reading the present invention, any modifications of the present invention in various equivalent forms by those skilled in the art fall within the scope of the appended claims.

[0010] Unless otherwise specified, all raw materials and reagents used in this invention are from the conventional market.

[0011] Example 1 A method for preparing a vision protection eye drop includes the following steps: Step 1: Mix and dissolve 1 part propylene glycol and 0.8 parts E1004 completely to obtain mixture A; mix and dissolve 1 part propylene glycol, 0.2 parts borneol and 0.06 parts menthol completely to obtain mixture B; mix and dissolve 20 parts deionized water, 0.5 parts vitamin B6, 0.5 parts taurine and 2 parts protective extract completely to obtain mixture C; mix and dissolve 20 parts deionized water and 0.05 parts dipotassium glycyrrhizate completely to obtain mixture D. The protective extract was prepared by pulverizing a mixture of chrysanthemum, green tea, eucommia leaves, and hibiscus flowers in a mass ratio of 10:5:4:5, subjecting the mixture to high-pressure cell disruption at 0.02 MPa for 4 minutes, and then extracting the mixture in an extraction vessel. The lipid-soluble extract was collected, and then 8 times the volume of water was added for ultrasonic extraction at 25 kHz for 2 hours to obtain a water-soluble extract. The lipid-soluble and water-soluble extracts were combined, microfiltered, and then compressed and dried under reduced pressure. The extraction conditions were as follows: using 10% (by weight of raw material) of food-grade ethanol as an entrainer, controlling the extraction pressure at 30 MPa, the extraction temperature at 43°C, the CO2 flow rate at 25 L / h, and the extraction time at 110 minutes.

[0012] The antibacterial ionic liquid is obtained by grinding 0.1 parts of ellagic acid and 0.06 parts of oat β-glucan to obtain a composite powder with a particle size of 2-4 μm, adding 5 parts of deionized water, and then adding 0.4 parts of nano silver ionic liquid (concentration of 1000 ppm) dropwise and stirring. The moisturizing polysaccharide is zinc hyaluronic acid and yeast β-glucan in a mass ratio of 1:2; Step 2: Add 1 / 4 deionized water and 0.05 parts sodium hyaluronate to the emulsification pot, stir and heat to 85℃ to dissolve, and keep warm for 30 minutes; Step 3: After cooling, add mixture A while stirring; cool to 40℃ and add mixtures B, C, and D, along with 2 parts antibacterial ionic liquid, 0.6 parts witch hazel distillate, 2 parts moisturizing polysaccharide, 1 part propylene glycol, and 20 parts deionized water; the cooling temperature is 40℃. Step 4: Test viscosity and pH, then filter the material through a 100-mesh filter cloth.

[0013] Example 2 A method for preparing a vision protection eye drop includes the following steps: Step 1: Mix and dissolve 0.7 parts propylene glycol and 0.8 parts E1004 completely to obtain mixture A; mix and dissolve 0.7 parts propylene glycol, 0.1 parts borneol and 0.02 parts menthol completely to obtain mixture B; mix and dissolve 17 parts deionized water, 0.1 parts vitamin B6, 0.1 parts taurine and 1 part protective extract completely to obtain mixture C; mix and dissolve 17 parts deionized water and 0.01 parts dipotassium glycyrrhizate completely to obtain mixture D. The protective extract was prepared by pulverizing a mixture of chrysanthemum, green tea, eucommia leaves, and hibiscus flowers in a mass ratio of 5:1:3:2, subjecting the mixture to high-pressure cell disruption at 0.01 MPa for 3 minutes, and then extracting the mixture in an extraction vessel. The lipid-soluble extract was collected, and then 7 times the volume of water was added for ultrasonic extraction at 20 kHz for 2 hours to obtain a water-soluble extract. The lipid-soluble and water-soluble extracts were combined, microfiltered, and then compressed and dried under reduced pressure. The extraction conditions were as follows: 8% (by weight of raw material) of food-grade ethanol was used as an entrainer; the extraction pressure was controlled at 28 MPa; the extraction temperature at 40°C; the CO2 flow rate at 25 L / h; and the extraction time at 100 minutes.

[0014] The antibacterial ionic liquid is obtained by grinding 0.05 parts of ellagic acid and 0.03 parts of oat β-glucan to obtain a composite powder with a particle size of 2-4 μm, adding 4 parts of deionized water, and then adding 0.2 parts of nano silver ionic liquid (concentration of 1000 ppm) dropwise and stirring. The moisturizing polysaccharide is zinc hyaluronic acid and yeast β-glucan in a mass ratio of 1:1; Step 2: Add 17 parts deionized water and 0.01 parts sodium hyaluronate to an emulsifying pot, stir and heat to 85°C to dissolve, and keep warm for 25 minutes; The cooling temperature is 40°C; Step 3: After cooling, add mixture A while stirring; cool to 40℃ and add mixture B, mixture C and mixture D, 1 part antibacterial ionic liquid, 0.2 parts witch hazel distillate, 1 part moisturizing polysaccharide, 17 parts deionized water and 0.7 parts propylene glycol respectively; Step 4: Test viscosity and pH, then filter the material through a 100-mesh filter cloth.

[0015] Example 3 A method for preparing a vision protection eye drop includes the following steps: Step 1: Mix and dissolve 1.5 parts propylene glycol and 1 part E1004 completely to obtain mixture A; mix and dissolve 1.5 parts propylene glycol, 0.3 parts borneol and 0.1 parts menthol completely to obtain mixture B; mix and dissolve 25 parts deionized water, 1 part vitamin B6, 1 part taurine and 3 parts protective extract completely to obtain mixture C; mix and dissolve 25 parts deionized water and 0.1 part dipotassium glycyrrhizate completely to obtain mixture D. The protective extract was prepared by pulverizing a mixture of chrysanthemum, green tea, eucommia leaves, and hibiscus flowers in a mass ratio of 15:10:5:8, subjecting the mixture to high-pressure cell disruption at 0.03 MPa for 5 minutes, and then extracting the mixture in an extraction vessel. The lipid-soluble extract was collected, and then 10 times the volume of water was added for ultrasonic extraction at 30 kHz for 3 hours to obtain a water-soluble extract. The lipid-soluble and water-soluble extracts were combined, microfiltered, and then compressed and dried under reduced pressure. The extraction conditions were as follows: using 12% (by weight of raw material) of food-grade ethanol as an entrainer, controlling the extraction pressure at 32 MPa, the extraction temperature at 45°C, the CO2 flow rate at 25 L / h, and the extraction time at 120 minutes.

[0016] The antibacterial ionic liquid is obtained by grinding 0.15 parts of ellagic acid and 0.10 parts of oat β-glucan to obtain a composite powder with a particle size of 2-4 μm, adding 6 parts of deionized water, and then adding 0.5 parts of nano silver ionic liquid (concentration of 1000 ppm) dropwise and stirring. The moisturizing polysaccharide is zinc hyaluronic acid and yeast β-glucan in a mass ratio of 1:3; Step 2: Add 25 parts deionized water and 0.1 parts sodium hyaluronate to an emulsifying pot, stir and heat to 85°C to dissolve, and keep warm for 35 minutes; The cooling temperature is 45℃; Step 3: After cooling, add mixture A while stirring; cool to 40℃ and add mixture B, mixture C and mixture D, 3 parts antibacterial ionic liquid, 1 part witch hazel distillate, 3 parts moisturizing polysaccharide, 25 parts deionized water and 1.5 parts propylene glycol respectively. Step 4: Test viscosity and pH, then filter the material through a 100-mesh filter cloth.

[0017] Example 4 A method for preparing a vision protection eye drop includes the following steps: Step 1: Mix and dissolve 1.2 parts propylene glycol and 0.6 parts E1004 completely to obtain mixture A; mix and dissolve 1.2 parts propylene glycol, 0.1 parts borneol and 0.04 parts menthol completely to obtain mixture B; mix and dissolve 68 parts deionized water, 0.3 parts vitamin B6, 0.4 parts taurine and 2 parts protective extract completely to obtain mixture C; mix and dissolve 68 parts deionized water and 0.03 parts dipotassium glycyrrhizate completely to obtain mixture D. The protective extract was prepared by pulverizing a mixture of chrysanthemum, green tea, eucommia leaves, and hibiscus flowers in a mass ratio of 7:3:3:2, subjecting the mixture to high-pressure cell disruption at 0.01 MPa for 5 minutes, and then extracting the mixture in an extraction vessel. The lipid-soluble extract was collected, and then 8 times the volume of water was added for ultrasonic extraction at 30 kHz for 2 hours to obtain a water-soluble extract. The lipid-soluble and water-soluble extracts were combined, microfiltered, and then compressed and dried under reduced pressure. The extraction conditions were as follows: 9% (by weight of raw material) of food-grade ethanol was used as an entrainer; the extraction pressure was controlled at 28 MPa; the extraction temperature at 45°C; the CO2 flow rate at 25 L / h; and the extraction time at 110 minutes.

[0018] The antibacterial ionic liquid is obtained by grinding 0.07 parts of ellagic acid and 0.08 parts of oat β-glucan to obtain a composite powder with a particle size of 2-4 μm, adding 5 parts of deionized water, and then adding 0.3 parts of nano silver ionic liquid (concentration of 1000 ppm) dropwise and stirring. The moisturizing polysaccharide is zinc hyaluronic acid and yeast β-glucan in a mass ratio of 1:2; Step 2: Add 68 parts of deionized water and 0.03 parts of sodium hyaluronate to an emulsifying pot, stir and heat to 85°C to dissolve, and keep warm for 30 minutes; The cooling temperature is 40°C; Step 3: After cooling, add mixture A while stirring; cool to 40℃ and add mixture B, mixture C and mixture D, 1-3 parts antibacterial ionic liquid, 0.8 parts witch hazel distillate, 3 parts moisturizing polysaccharide, 1.2 parts propylene glycol and 68 parts deionized water respectively; Step 4: Test viscosity and pH, then filter the material through a 100-mesh filter cloth.

[0019] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that the extract of Comparative Example 1 does not contain Eucommia ulmoides leaves, while everything else remains the same.

[0020] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the control extract of Comparative Example 2 does not contain hibiscus flowers, while everything else remains the same.

[0021] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 uses a silver ion solution with plasma mass concentration instead of an antibacterial ion solution, while everything else remains the same.

[0022] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 does not contain moisturizing polysaccharides, while everything else remains the same.

[0023] Experimental animals: Several healthy 3-week-old tricolor guinea pigs (weighing 100-120g), with normal refractive status (equivalent spherical lens SE≥+0.50D), no ocular surface inflammation, and balanced microbial flora (confirmed by baseline testing). Grouping: The animals were randomly divided into 10 groups, with 10 animals in each group (only the right eye was used for the experiment, and the left eye served as a self-control). ① Experimental group: Eye drops were applied after modeling; ② Model control group: Physiological saline was applied after modeling; ③ Blank control group: No modeling or intervention was performed (baseline indicators were measured only). A composite model was constructed by "dual treatment" of the right eye of guinea pigs in both the experimental and model control groups, while the blank control group received no treatment. ① Visual deprivation: Cover the right eye with semi-transparent medical tape (leaving only 5% light transmittance) to induce axial myopia; ② Ocular surface irritation: Before covering the eyes every morning, instill 1 drop (50μL) of 0.05% benzalkonium chloride solution for 3 consecutive days to induce mild ocular surface inflammation (conjunctival hyperemia index ≥1 point) and flora imbalance (pathogenic bacteria count increased by 1 time). Modeling validation criteria: After 3 days, the right eye SE decreased by ≥0.30D compared to the left eye, BUT <8s, conjunctival hyperemia index ≥1 point, and ocular surface Escherichia coli count ≥10³CFU / mL.

[0024] After successful modeling, the experimental group received eye drops twice daily (one drop in the morning and one in the evening, 50 μL each time), while the model control group received an equal volume of physiological saline. This intervention lasted for 6 weeks. During this period, the group was kept in a state of visual deprivation, while the blank control group was fed normally. The following performance tests were performed on the eyes of the tricolor guinea pigs in each group. The test results are shown in Table 1. Conjunctival hyperemia index and tear IL-6 concentration: observed with a slit lamp (0-3 points), and tear samples were taken and detected by ELISA. Tear film breakup time (BUT) and tear secretion volume were recorded using slit lamp after staining with sodium fluorescein and the Schirmer I test strip method (5 min). Counting of pathogenic bacteria on the ocular surface: The ocular surface was wiped with a sterile cotton swab, inoculated with agar medium and incubated at 37°C for 24 hours, and the number of Escherichia coli and Staphylococcus aureus colonies was counted. Equivalent spherical lens (SE) and axial length: SE was measured using a retinoscope; axial length was measured using optical coherence tomography (OCT).

[0025] Table 1 Results of eye performance testing in tricolor guinea pigs As shown in Table 1, the vision control eye protection solution prepared by this invention has good anti-inflammatory, moisturizing, antibacterial and myopia control effects.

[0026] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A vision prevention eye care liquid, characterized in that, It comprises the following components: deionized water, propylene glycol, sodium hyaluronate, protective extract, bacteriostatic anti-inflammatory ionic liquid, vitamin B6, taurine, hamamelis distillate, dipotassium glycyrrhizinate, borneol, menthol, E1004, moisturizing polysaccharide.

2. The eye protection liquid according to claim 1, wherein It comprises the following components: deionized water 65-90 parts, propylene glycol 2-5 parts, sodium hyaluronate 0.01-0.1 parts, protective extract 1-3 parts, bacteriostatic ionic liquid 1-3 parts, vitamin B6 0.1-1 parts, taurine 0.1-1 parts, hamamelis distillate 0.2-1 parts, dipotassium glycyrrhizinate 0.01-0.1 parts, borneol 0.1-0.3 parts, menthol 0.02-0.1 parts, E1004 0.5-1 parts, moisturizing polysaccharide 1-3 parts.

3. The eye protection liquid according to claim 1, wherein The preparation of the protective extract is to crush the mixed plant raw materials composed of chrysanthemum, green tea, eucommia leaf and hibiscus flower, then high-pressure break wall for 3-5 min under the pressure of 0.01-0.03 MPa, put the broken wall raw materials into the extraction kettle for extraction, collect the fat-soluble extract after extraction, then add 7-10 times of water, ultrasonic extraction for 2-3 h under the ultrasonic frequency of 20-30 kHz to obtain water-soluble extract, combine the fat-soluble extract and water-soluble extract, then microfiltration and reduced pressure compression drying.

4. The eye protection liquid according to claim 3, wherein the liquid is a liquid for preventing and treating eye fatigue. The extraction conditions are to use 8-12% of food-grade ethanol as the entraining agent, control the extraction pressure at 28-32 MPa, the extraction temperature at 40-45℃, the CO2 flow at 25 L / h, and the extraction time at 100-120 min.

5. The eye protection liquid according to claim 3, wherein the liquid is a liquid for preventing and treating eye fatigue. The addition mass ratio of chrysanthemum, green tea, eucommia leaf and hibiscus flower in the mixed plant raw materials is (5-15):(1-10):(3-5):(2-8).

6. The eye protection liquid according to claim 1, wherein The bacteriostatic ionic liquid is to grind 0.05-0.15 parts of ellagic acid and 0.03-0.10 parts of oat beta-glucan to obtain a composite powder, add 4-6 parts of deionized water, and then drop 0.2-0.5 parts of nano silver ionic liquid (concentration of 1000 ppm) into the stirring to obtain.

7. The eye protection liquid according to claim 6, wherein The particle size of the composite powder is 2-4 μm.

8. The eye protection liquid according to claim 1, wherein The moisturizing polysaccharide is zinc hyaluronate and yeast beta-glucan with a mass ratio of 1:1-3.

9. A method for preparing a vision protection eye drop, for preparing a vision protection eye drop as claimed in any one of claims 1 to 8, characterized in that, It comprises the following steps: Step 1: completely dissolve 1 / 3 propylene glycol and E1004 to obtain mixture A, completely dissolve 1 / 3 propylene glycol, borneol and menthol to obtain mixture B, completely dissolve 1 / 4 deionized water, vitamin B6, taurine and protective extract to obtain mixture C, and completely dissolve 1 / 4 deionized water and dipotassium glycyrrhizinate to obtain mixture D; Step 2: put 1 / 4 deionized water and sodium hyaluronate into the emulsifying kettle, stir and heat to 85℃ for dissolution, and keep the temperature for 25-35 min; Step 3: after cooling, add mixture A while stirring, and then add mixture B, mixture C, mixture D and the remaining components while cooling to 40℃; Step 4: test the viscosity and ph, and filter the product through 100 mesh filter cloth.

10. The method of claim 9, wherein the eye protection liquid is prepared by the following steps: 1) mixing the ingredients of the eye protection liquid; 2) sterilizing the eye protection liquid; 3) filtering the eye protection liquid; 4) packaging the eye protection liquid. The temperature of the cooling in step 3 is 40-45℃.

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