Whole body ecological regulation and control anti-tumor method based on cell resource asking invisible mechanism

Abstract

The invention discloses a whole-body ecological regulation anti-tumor method based on a cell resource asking invisible mechanism, and belongs to the technical field of biological medicine and tumor treatment. By constructing a systemic low-energy supply baseline, normal cells enter an adaptive low-energy-consumption maintenance state, and meanwhile, abnormally proliferated cancer cells are systematically invisible due to a resource asking signal, so that the cancer cells naturally fail, sleep or die. The anti-tumor method disclosed by the invention has the advantages of no drug resistance, small toxic and side effects, wide application range and the like, can be applied to treatment of various solid tumors, and provides a brand-new and non-lethal technical path for cancer treatment.

Description

Technical Field

[0001] This invention belongs to the field of biomedicine and tumor treatment technology, specifically relating to an ecological regulation method that constructs a systemic low energy supply baseline, causing abnormally proliferating cells to naturally regress due to excessive resource extraction behavior that prevents them from obtaining a systemic response. Background Technology

[0002] Current cancer treatments are primarily based on killing, inhibiting, and attacking cancer cells, but they generally suffer from problems such as strong toxic side effects, damage to normal tissues, easy development of drug resistance, limited applicability, and high recurrence rates. Current treatment technologies mainly focus on drug intervention, targeted blockade, immune activation, and local microenvironment modification, but none have proposed a treatment model that systematically ignores the resource-demanding behavior of cancer cells to achieve natural tumor regression, nor have they established a systemic, unified, low-level resource supply baseline for ecological regulation. Summary of the Invention

[0003] The core of this invention lies in establishing a unified, systemic, and stable low-level resource supply baseline, which enables normal cells to adapt and maintain their level, while abnormally high-demand cells will eventually fail, become dormant, or undergo apoptosis due to the continuous lack of response to their resource requests.

[0004] This invention protects all technical means of achieving resource exploitation disregard, including but not limited to: oxygen concentration regulation, energy substrate regulation, nutrient supply regulation, metabolic environment regulation, signaling pathway regulation, and systemic microenvironment regulation. Any scheme that achieves anti-tumor effects by disregarding excessive resource exploitation by cancer cells falls within the scope of this invention. An anti-tumor method based on cellular resource exploitation disregard mechanism, characterized by comprising: 1. Establish a systemic, unified, low-level supply baseline within the organism; 2. To induce normal cells into an adaptive low-energy maintenance state; 3. It systematically ignores the excessive resource-demanding signals of abnormally proliferating cells; 4. Abnormal cells naturally exhaust, go into dormancy, or undergo apoptosis due to insufficient supply. As a preferred embodiment, the systemic uniform low-level supply baseline is achieved through a low-oxygen environment with an oxygen concentration range of 6%–16%; as a further preferred embodiment, the oxygen concentration range is 10%–12%.

[0005] The method includes any one or more of the following phases: induction phase, maintenance phase, recovery phase, and consolidation phase.

[0006] The method can be implemented independently or in any combination with surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

[0007] The abnormally proliferating cells include various solid tumors, circulating tumor cells, drug-resistant cells, dormant cancer cells, and cancer stem cells. Detailed Implementation Example

[0008] A systemic hypoxia baseline is established, with oxygen concentration controlled at 10%–12%, causing normal cells to enter an adaptive low-energy maintenance state. Abnormally proliferating cells, due to excessive resource consumption, are ignored by the system and gradually exhaust and die. The treatment process sequentially includes an induction phase, a maintenance phase, a recovery phase, and a consolidation phase, and can be implemented alone or in combination with existing tumor treatments. Example

[0009] By employing an energy substrate regulation approach to construct a systemic, unified, low-level supply baseline, normal cells maintain their basal metabolism, while abnormally proliferating cells, due to excessive demand, cannot obtain a systemic response and thus naturally decline. Example

[0010] By employing a nutrient supply regulation approach to establish a systemic, unified low-level supply baseline, combined with the combined effects of a hypoxic environment, the resource acquisition effect of abnormally proliferating cells is enhanced, thereby improving the broad-spectrum and stable anti-tumor activity.

Claims

1. An anti-tumor method based on the mechanism of ignoring cellular resource acquisition, characterized in that, include: By establishing a systemic, uniform, low-level supply baseline within the organism, normal cells enter an adaptive, low-energy-consumption maintenance state, while the excessive resource-demanding signals of abnormally proliferating cells are systematically ignored, leading to the natural exhaustion, dormancy, or apoptosis of these abnormally proliferating cells due to insufficient supply.

2. The method according to claim 1, characterized in that, The construction method of the systemic unified low-level supply baseline is selected from at least one of the following: oxygen concentration regulation, energy substrate regulation, nutrient supply regulation, metabolic environment regulation, signaling pathway regulation, and systemic microenvironment regulation.

3. The method according to claim 2, characterized in that, The systemic, uniform low-level supply baseline is achieved by creating a hypoxic environment with an oxygen concentration ranging from 6% to 16%.

4. The method according to claim 3, characterized in that, The oxygen concentration range of the hypoxic environment is 10%–12%.

5. The method according to claim 1, characterized in that, The method includes any one or more of the following phases: induction phase, maintenance phase, recovery phase, and consolidation phase.

6. The method according to claim 1, characterized in that, The method can be implemented independently or in combination with any one or more of surgical treatment, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

7. The method according to claim 1, characterized in that, The abnormally proliferating cells are selected from at least one of the following: solid tumor cells, circulating tumor cells, drug-resistant tumor cells, dormant tumor cells, and cancer stem cells.

8. A tumor ecosystem regulation system for implementing the method according to any one of claims 1-7, characterized in that, This system can establish and maintain a uniform, low-level supply baseline throughout the body to systematically ignore the excessive resource-demanding signals from abnormally proliferating cells.