Brewable composition for assisting in improving memory and application thereof

Abstract

The invention discloses an instant composition for assisting in improving memory and application of the instant composition. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 5-10 parts of thunberg fritillary bulb, 3-10 parts of allium macrostemon, 1-3 parts of turmeric, 10-20 parts of salvia miltiorrhiza, 5-10 parts of red peony root, 3-10 parts of peach kernel, 2-10 parts of safflower, 3-10 parts of immature bitter orange, 3-10 parts of mangnolia officinalis, 10-15 parts of rhizoma smilacis glabrae, 10-30 parts of prepared rehmannia root, 5-10 parts of Chinese yam, 4-10 parts of dogwood, 3-10 parts of rhizoma alismatis, 3-10 parts of radix achyranthis bidentatae, 3-10 parts of poria cocos and 3-10 parts of rhizoma atractylodis. Through the scientific compatibility of the selected 21 traditional Chinese medicines and the modern extraction and dosage form process, the multi-component and multi-target synergistic memory improvement is realized, and meanwhile, the traditional Chinese medicine composition has natural safety, efficient absorption and taking convenience.

Description

Technical Field

[0001] This invention relates to the field of health and wellness product technology, specifically to a reconstituteable composition that helps improve memory and its application. Background Technology

[0002] Memory is a core component of human cognitive function, and its strength directly affects learning, work efficiency, and quality of daily life. With the acceleration of global population aging, the incidence of memory decline-related symptoms (such as mild cognitive impairment and early signs of Alzheimer's disease) in the elderly is rising year by year, becoming a pressing social health problem. At the same time, the fast-paced lifestyle, long-term mental stress, and irregular work and rest schedules and diets in modern society are causing memory decline to gradually appear at younger ages. Problems such as low learning efficiency and increased work errors caused by poor memory are becoming increasingly prominent among teenagers and young adults, making the demand for products that help improve memory increasingly urgent.

[0003] Currently, products on the market that help improve memory mainly include chemically synthesized drugs, single-ingredient health supplements, and traditional Chinese medicine preparations. While chemically synthesized drugs offer rapid short-term effects, they generally have significant side effects and raise concerns about the safety of long-term use. Single-ingredient health supplements (such as DHA and ginkgo biloba extract) have a single mechanism of action, making it difficult to achieve a multi-target synergistic effect in improving memory. Although traditional Chinese medicine preparations have the advantages of being mild and safe, most suffer from unreasonable ingredient combinations, crude extraction processes leading to low utilization of effective ingredients, limited dosage forms (mostly decoctions or pills), inconvenient administration, and poor taste. In particular, there is a lack of dissolvable dosage forms suitable for modern fast-paced lifestyles, failing to meet consumers' comprehensive needs for convenience, palatability, and effectiveness.

[0004] Therefore, a reconstituteable composition for improving memory and its application are proposed to address the problems mentioned above. Summary of the Invention

[0005] The purpose of this invention is to provide a reconstituteable composition for assisting in improving memory and its application, in order to solve the limitations of current memory improvement products mentioned in the background art, such as short-term side effects, single mechanism of action, low component utilization rate or inconvenient dosage form, which make it difficult to meet the comprehensive needs of modern consumers for convenience, safety and efficiency.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a composition for assisting in improving memory, comprising an extract prepared by extraction of a traditional Chinese medicine composition including the following parts by weight: 5-10 parts of Fritillaria thunbergii, 3-10 parts of Allium macrostemon, 1-3 parts of Curcuma longa, 10-20 parts of Salvia miltiorrhiza, 5-10 parts of Paeonia lactiflora, 3-10 parts of Prunus persica, 2-10 parts of Carthamus tinctorius, 3-10 parts of Citrus aurantium, 3-10 parts of Magnolia officinalis, 10-15 parts of Smilax glabra, 10-30 parts of Rehmannia glutinosa, 5-10 parts of Dioscorea opposita, 4-10 parts of Cornus officinalis, 3-10 parts of Alisma plantago-aquatica, 3-10 parts of Achyranthes bidentata, 3-10 parts of Poria cocos, 3-10 parts of Atractylodes lancea, 3-10 parts of Angelica dahurica, 0.5-5 parts of Panax ginseng, 3-10 parts of Ophiopogon japonicus, and 1-5 parts of Schisandra chinensis.

[0007] Preferably, the amounts of the raw materials are as follows: 7-9 parts of Fritillaria thunbergii, 5-8 parts of Allium macrostemon, 1.5-2.5 parts of Curcuma longa, 13-17 parts of Salvia miltiorrhiza, 6-8 parts of Paeonia lactiflora, 5-8 parts of Prunus persica, 4-7 parts of Carthamus tinctorius, 5-8 parts of Citrus aurantium, 5-8 parts of Magnolia officinalis, 11-13 parts of Smilax glabra, 15-25 parts of Rehmannia glutinosa, 6-8 parts of Dioscorea opposita, 5-8 parts of Cornus officinalis, 5-8 parts of Alisma plantago-aquatica, 5-8 parts of Achyranthes bidentata, 5-8 parts of Poria cocos, 5-8 parts of Atractylodes lancea, 5-8 parts of Angelica dahurica, 1-3 parts of Panax ginseng, 5-8 parts of Ophiopogon japonicus, and 2-4 parts of Schisandra chinensis.

[0008] Preferably, the amounts of the raw materials are as follows: 8 parts of Fritillaria thunbergii, 6 parts of Allium macrostemon, 2 parts of Curcuma longa, 15 parts of Salvia miltiorrhiza, 7 parts of Paeonia lactiflora, 6 parts of Prunus persica, 5 parts of Carthamus tinctorius, 6 parts of Citrus aurantium, 6 parts of Magnolia officinalis, 12 parts of Smilax glabra, 20 parts of Rehmannia glutinosa, 7 parts of Dioscorea opposita, 6 parts of Cornus officinalis, 6 parts of Alisma plantago-aquatica, 6 parts of Achyranthes bidentata, 6 parts of Poria cocos, 6 parts of Atractylodes lancea, 6 parts of Angelica dahurica, 2 parts of Panax ginseng, 6 parts of Ophiopogon japonicus, and 3 parts of Schisandra chinensis.

[0009] Preferably, the extract is an extract obtained by water extraction and / or alcohol extraction, and is prepared in the form of powder, granules or solid extract.

[0010] Preferably, when made into powder, the particle size is 80-200 mesh.

[0011] Preferably, it also includes food or health product-acceptable excipients; the excipients are selected from at least one of sweeteners, thickeners, excipients, anti-caking agents, dispersants, and flavoring agents.

[0012] Preferably, the sweetener is selected from at least one of white sugar, brown sugar, glucose, fructose, sorbitol, maltitol, xylitol, and erythritol; the thickener is selected from at least one of xanthan gum, tamarind gum, resistant dextrin, carrageenan, gelatin, konjac gum, and guar gum; and the excipient is selected from at least one of milk powder, maltodextrin, soluble starch, and microcrystalline cellulose.

[0013] Preferably, the milk powder is whole milk powder or skim milk powder.

[0014] The present invention also provides a method for using the aforementioned composition to aid in improving memory, comprising the following steps:

[0015] (1) Weigh out the following ingredients according to the specified proportions: Fritillaria thunbergii, Allium macrostemon, Curcuma longa, Salvia miltiorrhiza, Paeonia lactiflora, Prunus persica, Carthamus tinctorius, Citrus aurantium, Magnolia officinalis, Smilax glabra, Rehmannia glutinosa, Dioscorea opposita, Cornus officinalis, Alisma plantago-aquatica, Achyranthes bidentata, Poria cocos, Atractylodes lancea, Angelica dahurica, Panax ginseng, Ophiopogon japonicus, and Schisandra chinensis, and mix them together.

[0016] (2) Extract the mixed raw materials with water and / or ethanol to obtain an extract;

[0017] (3) The extract is concentrated and dried to obtain the composition.

[0018] Preferably, in step (2), the extraction is water decoction extraction, and the number of decoctions is 1-3 times; in step (3), the drying is spray drying, freeze drying or vacuum drying.

[0019] The present invention also provides the use of the composition for improving memory in the preparation of foods, health foods or medicines for improving memory.

[0020] The present invention also provides a food or health food for assisting in improving memory, characterized in that it comprises the composition as described in any one of claims 1-8.

[0021] Preferably, it is in the form of powder, solid beverage, compressed candy, capsule, tablet or jelly.

[0022] Compared with existing technologies, the beneficial effects of this invention are: this reconstituteable composition for improving memory and its application, through the scientific formulation of twenty-one carefully selected traditional Chinese medicines and modern extraction and dosage form processes, achieves multi-component, multi-target synergistic improvement of memory, while also taking into account natural safety, efficient absorption, and convenient administration. The specific details are as follows:

[0023] First, the composition of this invention uses 21 carefully selected traditional Chinese medicines, including Fritillaria thunbergii, Allium macrostemon, Salvia miltiorrhiza, Rehmannia glutinosa, and ginseng, as raw materials. These raw materials work synergistically and complement each other in terms of efficacy. Among them, Salvia miltiorrhiza, Paeonia lactiflora, Prunus persica, and Carthamus tinctorius, which promote blood circulation and remove blood stasis, can improve cerebral blood circulation and provide sufficient nutrition to brain tissue; Rehmannia glutinosa, Dioscorea opposita, and Cornus officinalis, which nourish the liver and kidneys, can nourish the brain marrow and solidify the physiological foundation for improved memory; and Ginseng, Ophiopogon japonicus, and Schisandra chinensis, which invigorate qi and nourish yin, can enhance bodily vitality and improve symptoms of brain function decline. Compared to single-component health products with a single mechanism of action in the background art (such as DHA and Ginkgo biloba extract), this invention, through the synergistic effect of multiple components and multiple targets, can more comprehensively and effectively assist in improving memory. Furthermore, the composition of this invention uses all natural traditional Chinese medicine raw materials, which, compared to chemically synthesized drugs, fundamentally avoids significant side effects and safety risks associated with long-term use. Moreover, compared to traditional Chinese medicine preparations with unreasonable ingredient combinations, the scientific formulation of this invention further ensures the effectiveness and safety of the product.

[0024] Secondly, in terms of extraction technology, this invention employs water extraction and / or alcohol extraction, and prepares the extract through reasonable concentration and drying processes (such as spray drying, freeze drying, etc.). Compared with the crude extraction process of traditional Chinese medicine preparations, this invention can more fully extract the effective components from the raw materials, improve the utilization rate of effective components, and thus enhance the product efficacy. In terms of dosage form design, this invention prepares the extract into a reconstituteable powder (particle size controlled at 80-200 mesh to ensure reconstitution and solubility), and can add food- or health-product-acceptable excipients (such as sweeteners, flavoring agents, etc.) to improve the taste. Compared with traditional Chinese medicine preparations such as decoctions and pills, this invention has the advantages of convenient administration, easy portability, and good palatability, perfectly meeting the convenience needs of consumers in today's fast-paced lifestyle. It solves the defects of traditional Chinese medicine preparations, such as inconvenience in administration, poor taste, and lack of dosage forms suitable for modern life. Detailed Implementation

[0025] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0026] Example 1

[0027] Raw material formula (by weight): Fritillaria thunbergii 8 parts, Allium macrostemon 6 parts, Curcuma longa 2 parts, Salvia miltiorrhiza 15 parts, Paeonia lactiflora 7 parts, Prunus persica 6 parts, Carthamus tinctorius 5 parts, Citrus aurantium 6 parts, Magnolia officinalis 6 parts, Smilax glabra 12 parts, Rehmannia glutinosa 20 parts, Dioscorea opposita 7 parts, Cornus officinalis 6 parts, Alisma plantago-aquatica 6 parts, Achyranthes bidentata 6 parts, Poria cocos 6 parts, Atractylodes lancea 6 parts, Angelica dahurica 6 parts, Panax ginseng 2 parts, Ophiopogon japonicus 6 parts, Schisandra chinensis 3 parts; excipients: maltodextrin 10 parts, xylitol 5 parts, xanthan gum 0.5 parts.

[0028] Preparation method

[0029] (1) Raw material pretreatment: The above 21 kinds of Chinese medicinal materials are crushed to 40 mesh, and then each raw material is accurately weighed according to the ratio and placed in a mixer for 15 minutes to obtain a uniform mixed raw material powder;

[0030] (2) Water extraction: Add 10 times the mass of purified water to the mixed raw material powder, soak for 30 minutes, heat to boiling, maintain a gentle boil and simmer for 1.5 hours, filter to obtain the first extract; add 8 times the mass of purified water to the filter residue, heat to boiling again and simmer for 1 hour, filter to obtain the second extract; combine the two extracts and filter to remove impurities using a 200-mesh filter.

[0031] (3) Concentration: The filtered combined extract is placed in a vacuum concentration tank and concentrated under vacuum conditions of 0.06-0.08 MPa and 60-70℃ until the relative density of the concentrate reaches 1.25-1.30 (measured at 60℃) to obtain the Chinese herbal extract;

[0032] (4) Drying and powdering: Mix the Chinese herbal extract with the pre-set excipients (maltodextrin, xylitol, xanthan gum) evenly, and then dry it using a spray dryer. Set the inlet air temperature to 180℃ and the outlet air temperature to 80℃. After drying, dry powder is obtained. The dry powder is pulverized using a universal pulverizer and passed through a 120-mesh sieve to obtain a powder of the reconstituted composition.

[0033] (5) Packaging: The sieved powder is packed into aluminum foil bags, 5g per bag, and sealed to obtain the finished product.

[0034] Product Feature Testing

[0035] The properties of the refillable composition prepared in this embodiment were tested, and the results are as follows:

[0036] Appearance: Pale yellow, uniform powder, without obvious lumps or impurities;

[0037] Particle size: 99.2% passing rate for 120 mesh, meeting the requirements for 80-200 mesh particle size;

[0038] Solubility: Take 5g of this product, add 100mL of 40℃ warm water, stir for 30 seconds and it will dissolve completely. The solution is clear and there is no obvious precipitate.

[0039] Moisture content: Detected using the Karl Fischer method, the moisture content is 3.2%, which meets the moisture requirements for food / health food raw materials (≤8%).

[0040] Stability: After being sealed and stored at room temperature (25℃) and relative humidity of 60% for 6 months, there were no significant changes in the product's appearance and solubility. The microbiological indicators (total bacterial count ≤100cfu / g, mold and yeast ≤10cfu / g, no pathogenic bacteria) met the requirements of GB16740-2014 "General Standard for Health Food".

[0041] Example 2

[0042] Raw material formula (by weight): Fritillaria thunbergii 7 parts, Allium macrostemon 5 parts, Curcuma longa 1.5 parts, Salvia miltiorrhiza 13 parts, Paeonia lactiflora 6 parts, Prunus persica 5 parts, Carthamus tinctorius 4 parts, Citrus aurantium 5 parts, Magnolia officinalis 5 parts, Smilax glabra 11 parts, Rehmannia glutinosa 15 parts, Dioscorea opposita 6 parts, Cornus officinalis 5 parts, Alisma plantago-aquatica 5 parts, Achyranthes bidentata 5 parts, Poria cocos 5 parts, Atractylodes lancea 5 parts, Angelica dahurica 5 parts, Panax ginseng 1 part, Ophiopogon japonicus 5 parts, Schisandra chinensis 2 parts; excipients are whole milk powder 8 parts, erythritol 4 parts, and carrageenan 0.3 parts.

[0043] Preparation method

[0044] (1) Raw material pretreatment: Same as step (1) in Example 1, to obtain mixed raw material powder;

[0045] (2) Alcohol extraction: Add 8 times the mass of 70% ethanol solution to the mixed raw material powder, heat to reflux (temperature 78-80℃), reflux for 1.5 hours, filter to obtain the first extract; add 6 times the mass of 70% ethanol solution to the filter residue, reflux for 1 hour again, filter to obtain the second extract; combine the two extracts, and recover ethanol under reduced pressure (vacuum degree 0.07-0.09MPa, temperature 50-60℃) until there is no ethanol smell, to obtain the concentrated alcohol extract;

[0046] (3) Subsequent processing: The alcohol extract concentrate was concentrated to a relative density of 1.25-1.30 under the conditions of step (3) in Example 1. Then it was mixed evenly with excipients (whole milk powder, erythritol, carrageenan) and dried for 24 hours using a freeze-drying process (temperature -40℃, vacuum degree 10Pa). After drying, it was pulverized through a 100-mesh sieve and packaged to obtain the finished product.

[0047] Product Feature Testing

[0048] Test results show that this product is a light yellow powder with a 98.8% pass rate through a 100-mesh sieve. 5g of this product can be completely dissolved in 100mL of 30℃ warm water. The moisture content is 2.8%. It has good stability after being sealed at room temperature for 6 months. The microbiological indicators meet the relevant standard requirements.

[0049] Example 3

[0050] Raw material formula (by weight): Fritillaria thunbergii 5 parts, Allium macrostemon 3 parts, Curcuma longa 1 part, Salvia miltiorrhiza 10 parts, Paeonia lactiflora 5 parts, Prunus persica 3 parts, Carthamus tinctorius 2 parts, Citrus aurantium 3 parts, Magnolia officinalis 3 parts, Smilax glabra 10 parts, Rehmannia glutinosa 10 parts, Dioscorea opposita 5 parts, Cornus officinalis 4 parts, Alisma plantago-aquatica 3 parts, Achyranthes bidentata 3 parts, Poria cocos 3 parts, Atractylodes lancea 3 parts, Angelica dahurica 3 parts, Panax ginseng 0.5 parts, Ophiopogon japonicus 3 parts, Schisandra chinensis 1 part; excipients are soluble starch 12 parts, sorbitol 6 parts, and konjac gum 0.4 parts.

[0051] Preparation method

[0052] (1) Raw material pretreatment: Same as step (1) in Example 1;

[0053] (2) Water-ethanol mixture extraction: First, add 10 times the mass of purified water to the mixed raw material powder, boil and then simmer for 1 hour, filter to obtain water extract; then add 7 times the mass of 60% ethanol solution to the filter residue, reflux for 1 hour, filter to obtain ethanol extract; combine water extract and ethanol extract, concentrate under reduced pressure (under the same conditions as in Example 1) to a relative density of 1.25-1.30;

[0054] (3) Drying and molding: Mix the concentrated liquid and the auxiliary materials evenly, and dry them for 8 hours using a vacuum drying process (temperature 50℃, vacuum degree 0.05MPa). After drying, pulverize and pass through a 150-mesh sieve, and package to obtain the finished product.

[0055] Product Feature Testing

[0056] This product is a light brown powder with a 99.0% pass rate through a 150-mesh sieve. It has good solubility, a moisture content of 3.5%, and meets the stability requirements.

[0057] Experiment to verify the effect of assisting in improving memory

[0058] Experimental materials

[0059] Laboratory animals: 60 male SPF-grade ICR mice, weighing 20-22g, provided by a laboratory animal center;

[0060] Experimental samples: The refillable compositions prepared in Examples 1 and 3 of this invention are respectively numbered as Sample A and Sample C;

[0061] Control sample: A mixture of excipients without Chinese herbal extracts (10 parts maltodextrin + 5 parts xylitol + 0.5 parts xanthan gum), designated as sample D.

[0062] Experimental grouping and administration method

[0063] Sixty mice were randomly divided into four groups of 15 mice each: a blank control group (no medication, normal diet and water), sample group A, sample group C, and sample group D. Sample groups A, C, and D were administered the medication by gavage at a dose of 0.5 g / kg·d (based on the dry weight of the composition). The samples were dissolved in physiological saline and then administered by gavage. The blank control group was administered an equal volume of physiological saline by gavage. The administration was continued for 30 days.

[0064] Experimental Method (Morris Water Maze Experiment)

[0065] Thirty days after administration, the learning and memory abilities of mice were tested using the Morris water maze test, which consisted of two phases: a navigation experiment and a space exploration experiment.

[0066] (1) Positioning and navigation experiment: Training was conducted for 5 consecutive days, 4 times a day. Each time, the mice were placed in the water from different quadrants. The time it took for the mice to find the underwater hidden platform (escape latency) was recorded. If the mice did not find the platform within 60 seconds, they were guided to stay on the platform for 10 seconds. The escape latency was recorded as 60 seconds.

[0067] (2) Space exploration experiment: On the 6th day, the platform was removed and the mice were placed in the water from the entry point in the opposite quadrant of the original platform. The number of times the mice crossed the original platform position and the percentage of time spent in the quadrant where the original platform was located were recorded within 60 seconds.

[0068] Experimental results

[0069] The results of the navigation experiment (Table 1) showed that as the number of training days increased, the escape latency of mice in each group gradually shortened. However, the escape latency of sample A and sample C shortened significantly faster than that of the blank control group and sample D. On the 5th day of training, the escape latency of sample A was (12.3±2.5) seconds, sample C was (15.8±3.1) seconds, the blank control group was (28.6±4.2) seconds, and sample D was (27.9±3.8) seconds. The differences between sample A and sample C and the blank control group and sample D were statistically significant (P<0.05).

[0070] The results of the space exploration experiment (Table 2) show that the number of times mice in sample A crossed the original platform within 60 seconds was (6.2±1.3) times, and the proportion of time spent in the original platform quadrant was (42.5±3.8)%; the number of times mice in sample C crossed the platform was (5.1±1.1) times, and the proportion of time spent in the original platform quadrant was (38.2±3.5)%; the number of times mice in the blank control group crossed the platform was (2.3±0.8) times, and the proportion of time spent in the blank control group was (25.3±2.6)%; and the number of times mice in sample D crossed the platform was (2.5±0.9) times, and the proportion of time spent in the blank control group was (26.1±2.9)%. The number of times mice crossed the platform and the proportion of time spent in the blank control group and sample D were significantly higher than those in sample A and sample C (P<0.05), and sample A performed better than sample C.

[0071] Table 1. Escape latency in the localization and navigation experiment for each group of mice (unit: seconds)

[0072] Group Day 1 of training Day 2 of training Day 3 of training Day 4 of training Day 5 of training Blank control group 52.6±5.3 45.8±4.7 38.5±4.1 32.4±3.9 28.6±4.2 Sample A group 51.8±5.1 36.2±3.5 22.5±2.8 16.8±2.6 12.3±2.5 Sample C group 52.1±5.2 40.5±4.0 28.6±3.3 21.3±3.0 15.8±3.1 Sample D group 52.3±5.0 44.9±4.5 37.8±4.2 31.5±3.7 27.9±3.8

[0073] Table 2 Results of spatial exploration experiments in each group of mice

[0074] Group Number of times the original platform was crossed (times) Percentage of time spent in the original platform quadrant (%) Blank control group 2.3±0.8 25.3±2.6 Sample A group 6.2±1.3 42.5±3.8 Sample C group 5.1±1.1 38.2±3.5 Sample D group 2.5±0.9 26.1±2.9

[0075] Experimental conclusion: The reversible composition for improving memory prepared in this invention can significantly shorten the escape latency in the water maze of mice, increase the number of times the original platform is crossed and the proportion of time spent in the original platform quadrant, indicating that it has a good effect on improving memory. Moreover, the optimal ratio (Example 1) is better than the basic ratio (Example 3).

[0076] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for assisting in improving memory, characterized in that, An extract prepared from a combination of traditional Chinese medicine ingredients comprising the following parts by weight: Fritillaria thunbergii 5-10 parts, Allium macrostemon 3-10 parts, Curcuma longa 1-3 parts, Salvia miltiorrhiza 10-20 parts, Paeonia lactiflora 5-10 parts, Prunus persica 3-10 parts, Carthamus tinctorius 2-10 parts, Citrus aurantium 3-10 parts, Magnolia officinalis 3-10 parts, Smilax glabra 10-15 parts, Rehmannia glutinosa 10-30 parts, Dioscorea opposita 5-10 parts, Cornus officinalis 4-10 parts, Alisma plantago-aquatica 3-10 parts, Achyranthes bidentata 3-10 parts, Poria cocos 3-10 parts, Atractylodes lancea 3-10 parts, Angelica dahurica 3-10 parts, Panax ginseng 0.5-5 parts, Ophiopogon japonicus 3-10 parts, Schisandra chinensis 1-5 parts.

2. The composition according to claim 1, characterized in that, The amounts of the raw materials are as follows: Fritillaria thunbergii 7-9 parts, Allium macrostemon 5-8 parts, Curcuma longa 1.5-2.5 parts, Salvia miltiorrhiza 13-17 parts, Paeonia lactiflora 6-8 parts, Prunus persica 5-8 parts, Carthamus tinctorius 4-7 parts, Citrus aurantium 5-8 parts, Magnolia officinalis 5-8 parts, Smilax glabra 11-13 parts, Rehmannia glutinosa 15-25 parts, Dioscorea opposita 6-8 parts, Cornus officinalis 5-8 parts, Alisma plantago-aquatica 5-8 parts, Achyranthes bidentata 5-8 parts, Poria cocos 5-8 parts, Atractylodes lancea 5-8 parts, Angelica dahurica 5-8 parts, Panax ginseng 1-3 parts, Ophiopogon japonicus 5-8 parts, Schisandra chinensis 2-4 parts.

3. The composition according to claim 2, characterized in that, The amounts of the raw materials are as follows: 8 parts of Fritillaria thunbergii, 6 parts of Allium macrostemon, 2 parts of Curcuma longa, 15 parts of Salvia miltiorrhiza, 7 parts of Paeonia lactiflora, 6 parts of Prunus persica, 5 parts of Carthamus tinctorius, 6 parts of Citrus aurantium, 6 parts of Magnolia officinalis, 12 parts of Smilax glabra, 20 parts of Rehmannia glutinosa, 7 parts of Dioscorea opposita, 6 parts of Cornus officinalis, 6 parts of Alisma plantago-aquatica, 6 parts of Achyranthes bidentata, 6 parts of Poria cocos, 6 parts of Atractylodes lancea, 6 parts of Angelica dahurica, 2 parts of Panax ginseng, 6 parts of Ophiopogon japonicus, and 3 parts of Schisandra chinensis.

4. The composition according to any one of claims 1-3, characterized in that, The extract is obtained by water extraction and / or alcohol extraction and is prepared in the form of powder, granules or solid extract.

5. The composition according to claim 4, characterized in that, When made into powder, its particle size is 80-200 mesh.

6. The composition according to claim 5, characterized in that, It also contains food or health product-acceptable excipients; said excipients are selected from at least one of sweeteners, thickeners, excipients, anti-caking agents, dispersants, and flavoring agents.

7. The composition according to claim 6, characterized in that, The sweetener is selected from at least one of white sugar, brown sugar, glucose, fructose, sorbitol, maltitol, xylitol, and erythritol; the thickener is selected from at least one of xanthan gum, tamarind gum, resistant dextrin, carrageenan, gelatin, konjac gum, and guar gum; and the excipient is selected from at least one of milk powder, maltodextrin, soluble starch, and microcrystalline cellulose.

8. The composition according to claim 7, characterized in that, The milk powder is whole milk powder or skim milk powder.

9. A method for preparing a composition for improving memory as described in any one of claims 1-8, characterized in that, Includes the following steps: (1) Weigh out the following ingredients according to the specified proportions: Fritillaria thunbergii, Allium macrostemon, Curcuma longa, Salvia miltiorrhiza, Paeonia lactiflora, Prunus persica, Carthamus tinctorius, Citrus aurantium, Magnolia officinalis, Smilax glabra, Rehmannia glutinosa, Dioscorea opposita, Cornus officinalis, Alisma plantago-aquatica, Achyranthes bidentata, Poria cocos, Atractylodes lancea, Angelica dahurica, Panax ginseng, Ophiopogon japonicus, and Schisandra chinensis, and mix them together. (2) Extract the mixed raw materials with water and / or ethanol to obtain an extract; (3) The extract is concentrated and dried to obtain the composition.

10. The method according to claim 9, characterized in that, In step (2), the extraction is water decoction extraction, and the number of decoctions is 1-3 times; in step (3), the drying is spray drying, freeze drying or vacuum drying.

11. The use of a composition for improving memory as described in any one of claims 1-8 in the preparation of a food, health food, or medicine for improving memory.

12. A food or health food for assisting in improving memory, characterized in that, The composition comprises any one of claims 1-8.

13. The food or health food according to claim 12, characterized in that, It is available in the form of powder, solid beverage, compressed candy, capsule, tablet or jelly.