Flow path switching valve and solid-phase synthesis reaction system

Abstract

The invention discloses a flow path switching valve and a solid-phase synthesis reaction system, and belongs to the technical field of rotary valves, the flow path switching valve comprises a stator and a rotor, the connecting end face of the stator is provided with at least five circulation holes, each circulation hole penetrates through the outer wall of the other end of the stator to form a component connecting hole, and the connecting end face of the stator is further provided with a stator groove; one end part of the stator groove is communicated with one circulation hole; a first rotor groove and a second rotor groove are formed in the connecting end face of the rotor, one of multiple communication states is achieved, and the multiple communication states include the first communication state, the first rotor groove or the second rotor groove is communicated with two adjacent circulation holes; in the second communication state, the first rotor groove and the second rotor groove directly communicate with two adjacent circulation holes; in the third communication state, the first rotor groove directly communicates with the two adjacent circulation holes, and the second rotor groove indirectly communicates with the two adjacent circulation holes by communicating with the stator groove. The use condition of the flow path switching valve is expanded by increasing the stator grooves, and the production efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of rotary valve technology, and in particular to a flow path switching valve and a solid-phase synthesis reaction system. Background Technology

[0002] In solid-phase synthesis, raw materials are covalently loaded onto a solid phase such as polystyrene. A liquid reagent then acts on the compound, resulting in the target compound on the solid phase. Finally, the mixture is solidified, excised from the phase, and transferred to the liquid phase. Solid-phase synthesis can be used to synthesize target compounds such as proteins, peptides, and nucleic acids. Solid-phase synthesis equipment includes a feed path, a reaction path, and a discharge path. The feed path includes an inlet valve, a system pump, and multiple reagent containers connected to the inlet valve, containing various reagents required for the synthesis reaction. The reaction path includes a premixer and a synthesis vessel. The synthesis vessel contains the solid support. The premixer is used to premix at least two reagents before they enter the synthesis vessel. The discharge path includes a detector and a waste container. The solid-phase synthesis equipment uses inert gas to purge the premixer and synthesis vessel to clean the reaction path. To achieve selective flow of materials and gases between the various components of the reaction equipment, flow path switching valves are needed to control the flow direction of materials and gases in a timely manner.

[0003] Flow path switching valves are generally rotary valves that use the relative rotation of the stator and rotor to switch the flow path. The stator is usually provided with flow holes, and the rotor is provided with grooves that connect the flow holes. Therefore, when the rotor rotates, the grooves can connect different flow holes to achieve flow path switching. Since the flow path of the flow path switching valve is designed to meet the flow of materials, and the flow of gas is achieved through this flow path, the gas can meet the condition of purging the premixer and the synthesis vessel separately after the switch. However, it cannot meet the condition of purging the premixer and the synthesis vessel simultaneously after the switch. Therefore, traditional flow path switching valves can only purge the premixer and the synthesis vessel independently, which not only wastes the gas source, but also reduces the efficiency of the entire solid-phase synthesis reaction. Summary of the Invention

[0004] The present invention aims to solve the problem that the above-mentioned flow path switching valve has few flow path switching conditions when performing gas purging function, and provides a flow path switching valve that has the advantages of increasing the number of flow paths by increasing the number of stator slots, increasing the purging conditions of the entire solid-phase synthesis reaction system, and improving working efficiency.

[0005] Firstly, to achieve the above objectives, the technical solution adopted by the present invention is as follows: A flow path switching valve includes a stator and a rotor. The connecting end face of the rotor is sealed and fits against the connecting end face of the stator and can rotate relative to each other. At least five flow holes are opened on the connecting end face of the stator. Each flow hole penetrates the outer wall of the other end of the stator to form a component connection hole. The connecting end face of the stator is also provided with a stator groove. One end of the stator groove communicates with one of the flow holes. A first rotor slot and a second rotor slot are formed on the connecting end face of the rotor. By rotating the rotor, one of multiple communication states between the first rotor slot and the second rotor slot and the flow hole and stator slot can be achieved. The multiple communication states include: In the first connected state, the first rotor slot or the second rotor slot connects two adjacent flow holes; In the second connected state, both the first rotor slot and the second rotor slot are directly connected to two adjacent flow holes; In the third connected state, the first rotor slot is directly connected to two adjacent flow holes, and the second rotor slot is indirectly connected to two adjacent flow holes by connecting to the stator slot.

[0006] Preferably, the flow holes include a first flow hole, a second flow hole, a third flow hole, a fourth flow hole, and a fifth flow hole. The first flow hole, the second flow hole, the third flow hole, the fourth flow hole, and the fifth flow hole are sequentially distributed on a circumference with the center of the connecting end face as the center and a radius of R1. The rotation axis of the rotor passes perpendicularly through the center of the connecting end face. The other end of the stator slot and all ends of the first rotor slot and the second rotor slot are also arranged on this circumference.

[0007] Preferably, in the first connected state, the first rotor slot or the second rotor slot is connected to the adjacent third flow hole and fourth flow hole.

[0008] Preferably, in the second connected state, the first rotor slot is directly connected to the adjacent first flow hole and second flow hole, and the second rotor slot is directly connected to the adjacent fourth flow hole and fifth flow hole.

[0009] Preferably, in the third connected state, the first rotor slot is directly connected to the adjacent second and third flow holes, one end of the second rotor slot is connected to the fifth flow hole, the other end of the second rotor slot is connected to the other end of the stator slot, and the second rotor slot is indirectly connected to the adjacent fourth and fifth flow holes by connecting the stator slot.

[0010] Preferably, the hole spacing between each of the flow holes and the nearest other flow hole is equal, the distance between the other end of the stator slot and the nearest flow hole is consistent with the hole spacing, and the distance between the two ends of the first rotor slot and the second rotor slot is consistent with the hole spacing.

[0011] Preferably, the slot width at the end of the stator slot, the slot width at the end of the first rotor slot and the second rotor slot, and the diameter of the flow hole are all the same.

[0012] Preferably, the ends of the first rotor slot and the second rotor slot are also distributed on a circumference with radius R1 centered on the center of the connecting end face, and a gap is provided between the adjacent ends of the first rotor slot and the second rotor slot.

[0013] Secondly, to achieve the above objectives, the technical solution adopted by the present invention is as follows: A solid-phase synthesis reaction system includes a flow path switching valve as described in the first aspect, and further includes a feed flow path, a discharge flow path, a gas source, a premixer, and a synthesis container. The inlet of the premixer is connected to a component connection hole and the outlet of the feed flow path, respectively. The component connection hole connected to the gas source corresponds to a flow hole in the stator slot. In the third connected state, the two adjacent flow holes connected to the first rotor slot correspond to a component connection hole connected to the synthesis container and a component connection hole connected to the premixer outlet, respectively. The two adjacent flow holes connected to the second rotor slot correspond to a component connection hole connected to the premixer inlet and a component connection hole connected to the gas source, respectively. The discharge flow path is connected to a component connection hole.

[0014] Preferably, a two-position three-way valve is installed at the inlet of the premixer, and one of the control component connection holes and the feed flow path outlet is connected to the inlet of the premixer through the two-position three-way valve.

[0015] Compared with the prior art, the present invention has the following beneficial effects: The flow path switching valve of this invention connects one of the flow holes by setting stator slots on the stator. When the rotor slots are connected to the stator slots, they can indirectly connect to the flow hole. Therefore, using the stator slots as indirect flow channels between the rotor slots and the flow holes increases the number of adjacent flow holes that the rotor slots can connect to without increasing the number of rotor slots and flow holes. This increases the flow path of the flow path switching valve, allowing it to meet more operational requirements. Thus, when applied to solid-phase synthesis reaction systems, this flow path switching valve can also improve the system's efficiency. For example, when the system requires gas purging of the premixer and synthesis vessel, it can add the option of simultaneously purging both the premixer and synthesis vessel, in addition to the existing option of purging them separately. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the stator structure flow hole distribution of the flow path switching valve of the present invention.

[0017] Figure 2This is a schematic diagram of the rotor structure and rotor slot distribution of the flow path switching valve of the present invention.

[0018] Figure 3 This is a schematic diagram of the overall structure of the flow path switching valve of the present invention.

[0019] Figure 4 This is a schematic diagram of a connectivity situation in the first connectivity state of the present invention.

[0020] Figure 5 This is a schematic diagram of another connectivity situation under the first connectivity state of the present invention.

[0021] Figure 6 This is a schematic diagram of the connectivity in the second connectivity state of the present invention.

[0022] Figure 7 This is a schematic diagram of the connectivity in the third connectivity state of the present invention.

[0023] Figure 8 This is a schematic diagram showing the connection between the components of the solid-phase synthesis reaction system of the present invention and the stator pipes.

[0024] Figure 9 This is a schematic diagram of the gas path when the synthesis container is purged by gas alone according to the present invention.

[0025] Figure 10 This is a schematic diagram of the gas path when the gas is purged separately from the premixer according to the present invention.

[0026] Figure 11 This is a schematic diagram of the gas path when the gas simultaneously purges the premixer and the synthesis container according to the present invention.

[0027] In the diagram: 1. Stator, 11. Flow hole, 12. Component connection hole, 13. Stator slot, 2. Rotor, 21. First rotor slot, 22. Second rotor slot, 3. Drive unit, 4. Controller, 5. Feed path, 6. Discharge path, 7. Air source, 8. Premixer, 9. Synthesis container, 10. Two-position three-way valve. Detailed Implementation

[0028] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0029] Example 1 like Figure 1 and Figure 2As shown, this invention proposes a flow path switching valve, including a stator 1 and a rotor 2. The connecting end face of the rotor 2 is sealed and fitted with the connecting end face of the stator 1 and can rotate relative to it. At least five flow holes 11 are formed on the connecting end face of the stator 1, and each flow hole 11 penetrates the outer wall of the other end of the stator 1 to form a component connection hole 12. Figure 8 As shown, the component connection hole 12 is used to connect the various components of the solid-phase synthesis reaction system. The connection end face of the stator 1 is also provided with a stator groove 13, and one end of the stator groove 13 is connected to one of the flow holes 11. A first rotor groove 21 and a second rotor groove 22 are formed on the connecting end face of the rotor 2. By rotating the rotor 2, one of a plurality of communication states between the first rotor groove 21 and the second rotor groove 22 and the flow hole 11 and the stator groove 13 can be achieved. The plurality of communication states include: In the first connected state, the first rotor slot 21 or the second rotor slot 22 connects two adjacent flow holes 11; In the second connected state, both the first rotor slot 21 and the second rotor slot 22 are directly connected to two adjacent flow holes 11. In the third connected state, the first rotor slot 21 is directly connected to two adjacent flow holes 11, and the second rotor slot 22 is indirectly connected to two adjacent flow holes 11 by connecting to the stator slot 13.

[0030] The flow holes 11 on the stator 1 are matched with the rotor slots of the rotor 2. The rotor slots serve as a connecting bridge between the two flow holes 11. When the two flow holes 11 are connected, a flow path is formed between the component connection holes 12 corresponding to the flow holes 11. The flow path switching valve is a rotary valve. As the rotor 2 rotates, the rotor slots connect or disconnect with the specific flow holes 11 on the stator 1, thereby realizing the switching of the flow path between the two different component connection holes 12. With the switching of the flow path, it adapts to different working conditions. For example, in the application of the flow path switching valve in solid-phase synthesis reaction, the reagent needs to flow between the various devices required for the solid-phase synthesis reaction. For different reaction processes, the flow path of the reagent is also different. Therefore, by using the flow path switching valve, the flow path of the reagent can be switched by controlling the rotation of the rotor 2 to meet the requirements of the solid-phase synthesis reaction.

[0031] The above explains that the main principle of the flow path switching valve is to utilize the flow path switching caused by the rotation of rotor 2. To control the rotation of rotor 2, rotor 2 needs to be connected to a drive assembly, such as... Figure 3As shown, the flow path switching valve also includes a drive unit 3 and a controller 4. The rotor 2 is connected to the output end of the drive unit 3, and the controller 4 is electrically connected to the drive unit 3 to input a rotation signal to the drive unit 3. The drive unit 3 serves as the power output for the rotation of the rotor 2. In order to accurately control the rotation of the rotor 2 through the drive unit 3, the drive unit 3 also needs to be connected to the controller 4. By inputting a rotation command to the controller 4, the drive unit 3 executes precise rotation to achieve the connection and disconnection of the rotor slots between the flow holes 11. The rotation command can be a rotation angle value. The drive unit 3 can be a stepper motor, or it is not limited to this combination. Since the drive components are common existing technologies, they will not be listed one by one. The stator 1 and rotor 2 are cylindrical or disc-shaped structures for the convenience of production and use.

[0032] The operating condition of the flow path switching valve is achieved by the connection between the rotor slot and the corresponding flow hole 11. Therefore, the position and number of the rotor slots need to match the position and number of the flow holes 11. In order to further expand the connection combination, when there are two rotor slots, in order to easily distinguish each rotor slot, the first rotor slot 21 and the second rotor slot 22 are referred to as slot 21 and slot 22 respectively in the following text. The stator 1 of the flow path switching valve is also provided with a stator slot 13, which has two ends such as Figure 1 The A1 and A2 ends are shown, where the A1 end is connected to the flow hole 11, and the A2 end is not connected to any flow hole 11. In this way, even if either of the two rotor slots is not directly connected to the flow hole 11 on the stator 1, it is indirectly connected to a flow hole 11 connected to the A1 end after being connected to the stator slot 13. With the setting of the stator slot 13, the number of times the rotor slot is connected to the flow hole 11 increases. This is because when either rotor slot is only connected to a single flow hole 11, the flow hole 11 cannot be used as a flow path for the flow path switching valve. It is equivalent to the two component connection holes 12 being in a disconnected state. Only when a single rotor slot is connected to two flow holes 11 at the same time is the component connection hole 12 corresponding to the two flow holes 11 connected and used as a flow path. Therefore, the connection between the two rotor slots and the flow hole 11 and the stator slot 13 can be divided into three cases.

[0033] They are: In the first connected state, either the first rotor slot 21 or the second rotor slot 22 connects to two adjacent flow holes 11. In this state, either the first rotor slot 21 or the second rotor slot 22 connects to two adjacent flow holes 11, while the other rotor slot does not connect to any two adjacent flow holes 11. Essentially, the flow path switching valve at this time only provides communication between two components. However, depending on the different flow holes 11 connected to the first rotor slot 21 or the second rotor slot 22, different single-flow-path applications can be achieved. For example, in a solid-phase synthesis reaction system, a flow path is formed between the premixer 8 and the synthesis container 9 to facilitate reagent synthesis, or a flow path is formed between the synthesis container 9 and the gas source 7 to facilitate gas source 7 purging the synthesis container 9. There are many operating conditions, which will not be listed individually. Taking five flow holes 11 as an example, numbered a, b, c, d, and e respectively... Figure 4 As shown in the figure, when slot 22 of the rotor connects to holes c and d, slot 21 only connects to hole a. Similarly, ... Figure 5 As shown, if slot 21 connects to holes c and d, slot 22 is connected to hole d only via stator slot 13. Therefore, in these two cases, rotor 2 can only achieve direct connection between a single rotor slot and two adjacent flow holes 11.

[0034] In the second connected state, both the first rotor slot 21 and the second rotor slot 22 are directly connected to two adjacent flow holes 11. Since both rotor slots are involved in the connection, in the second connected state, the flow path switching valve effectively provides two flow paths for connecting components. For example, one flow path is formed between the air supply source 7 and the premixer 8, and another flow path is formed between the premixer 8 and the discharge flow path 6. This is equivalent to the air supply source 7 purging and discharging waste from the premixer 8. Using the same example again... Figure 6 As shown, when slot 21 connects to holes a and b, slot 22 connects to holes e and d. This ensures that both rotor slots are directly connected to two adjacent connecting holes 11.

[0035] In the third connection state, the first rotor slot 21 directly connects to two adjacent flow holes 11, and the second rotor slot 22 indirectly connects to two adjacent flow holes 11 through the stator slot 13. This third connection state extends the functionality of the first two operating conditions by utilizing the stator slot 13. Since the positions of the flow holes 11 and the two rotor slots are fixed, the connection between the rotor slots and the flow holes 11 remains in a regular, cyclical state regardless of how the rotor 2 rotates. For example, in the first state, when a flow path is formed between the gas source 7 and the synthesis container 9, the position of the other rotor slot is also fixed and cannot connect to the other two adjacent flow holes 11. Therefore, to solve this problem, a stator slot 13 is added to the stator 1, thus adding another flow path operating condition to the flow path switching valve. When the first rotor slot 21 can directly connect to two adjacent flow holes 11, the second rotor slot 22 can indirectly connect to two adjacent flow holes 11, thereby achieving another operating condition. Using the same example... Figure 7 As shown, when slot 21 connects to holes b and c, slot 22 connects to hole e and end A2 of stator slot 13. Since end A2 is connected to end A1, and end A1 is connected to hole d, slot 22 is equivalent to indirectly connecting hole d and hole e. If there were no stator slot 13, it would be impossible to achieve the connection between slot 22 and holes d and e when slot 21 connects to holes b and c.

[0036] To ensure accurate connection between the first rotor slot 21 and the second rotor slot 22 and the flow hole 11 or the stator slot 13, the flow hole 11 is arranged on a circumference with radius R1 centered on the center of the connecting end face. The rotation axis of the rotor 2 passes perpendicularly through the center of the connecting end face. The other end of the stator slot 13 and all ends of the first rotor slot 21 and the second rotor slot 22 are also arranged on this circumference. Since the rotor 2 changes the position of the two rotor slots by rotation, to accommodate the rotation of the rotor 2, the flow hole 11, the A2 end of the stator slot 13, and the four ends of the two rotor slots are all arranged on a circumference with radius R1 centered on the center of the connecting end face. As the rotor slots rotate, the ends are aligned with the flow hole 11 or the A2 end. This circumference is an auxiliary reference line, not an actual line designed on the stator 1 or the rotor 2.

[0037] Furthermore, in order to achieve a single rotor slot connecting two adjacent flow holes 11, the flow holes 11 cannot be evenly distributed on the circumference. However, to facilitate the rotation control of the rotor 2, the hole spacing between each flow hole 11 and the nearest other flow hole 11 is equal. The distance between the other end of the stator slot 13 and the nearest flow hole 11 is consistent with the hole spacing. The distance between the two ends of the first rotor slot 21 and the second rotor slot 22 is consistent with the hole spacing. In this way, the hole spacing of the flow holes 11 is consistent, the distance between end A2 and the flow hole 11 is consistent, and the distance between the two ends of the two rotor slots is consistent. As long as the amplitude of each rotation of the rotor 2 matches the hole spacing, it can be ensured that the end of the rotor slot can be precisely aligned with the flow hole 11 or end A2. This makes designing the controller 4's instructions easier and makes the control of the entire flow path switching valve simple and quick.

[0038] Due to the above consistent design, the alignment of the end with the connecting hole 11 and the A2 end can be guaranteed. In order to ensure stronger sealing of the connection, the groove width of the end of the stator groove 13, the groove width of the end of the first rotor groove 21 and the second rotor groove 22, and the diameter of the flow hole 11 are all consistent. With consistent diameter, the sealing performance is also stronger after alignment.

[0039] To ensure the flow path switching valve can achieve the three connection states mentioned above and meet the application requirements of actual scenarios, the ends of the first rotor slot 21 and the second rotor slot 22 are also distributed on a circumference with radius R1 centered on the center of the connecting end face. A gap is provided between adjacent ends of the first rotor slot 21 and the second rotor slot 22. The gap is the hole spacing between the two connecting holes 11. This gap allows for better design of the rotor slot's position during each rotation.

[0040] Since both the rotor slot and stator slot 13 serve as connecting flow holes 11, the stator slot 13, the first rotor slot 21, and the second rotor slot 22 are all arc-shaped. This arc-shaped structure prevents the pressure within the flow path from increasing due to a small angle when gas or liquid flows from the rotor slot or stator slot 13 to the flow hole 11. The arc-shaped structure effectively reduces the impact of gas or liquid on the entire flow path. The arc-shaped structure is not mandatory; it is only one structure in this embodiment. The slots can also be of other shapes as long as they fulfill the function of connecting the flow hole 11. Examples are not provided here.

[0041] Example 2 like Figure 8As shown, a solid-phase synthesis reaction system includes a flow path switching valve as described in Example 1, and also includes a feed flow path 5, a discharge flow path 6, a gas source 7, a premixer 8, and a synthesis container 9. The inlet of the premixer 8 is connected to a component connection hole 12 and the outlet of the feed flow path 5, respectively. The component connection hole 12 connected to the gas source 7 corresponds to the flow hole 11 of the stator slot 13. In the third connected state, the flow path switching valve has two adjacent flow holes 11 connected to the first rotor slot 21, which correspond to a component connection hole 12 connected to the synthesis container 9 and a component connection hole 12 connected to the outlet of the premixer 8, respectively. The two adjacent flow holes 11 connected to the second rotor slot 22 correspond to a component connection hole 12 connected to the inlet of the premixer 8 and a component connection hole 12 connected to the gas source 7, respectively. The discharge flow path 6 is connected to a component connection hole 12.

[0042] A two-position three-way valve 10 is installed at the inlet of the premixer 8. The two-position three-way valve 10 controls one of the component connection holes 12 and the outlet of the feed flow path 5 to communicate with the inlet of the premixer 8.

[0043] Since the component connection hole 12 is formed by the flow hole 11 penetrating the outer wall of the stator 1, drilling a straight hole makes it easier to connect the flow hole 11 and the component connection hole 12 for ease of processing. However, it doesn't have to be a straight hole; there's no limitation. Therefore, each component connection hole 12 corresponds to one flow hole 11, and their positions also correspond. Taking the example of five flow holes 11 in Embodiment 1, the component connection hole 12 and the flow hole 11 are numbered 1a, 1b, 1c, 1d, and 1e, respectively. Hereinafter, holes 1a-1e will be used to refer to the component connection hole 12. The component connection hole 12 is a through-hole... The schematic diagram of the various connected states in Embodiment 1, where the components are connected by pipes, is a view from the connection end face of the stator 1. Therefore, in the diagram, the stator slot 13, the first rotor slot 21, and the second rotor slot 22 are solid lines. However, to facilitate understanding of the connection between the component connection hole 12 and each component, the schematic diagrams in the following description are shown from the view of the component connection hole 12, which is the opposite of that in Embodiment 1. The schematic diagrams are also mirror images. Therefore, the stator slot 13, the first rotor slot 21, and the second rotor slot 22 in the diagrams are dashed lines, indicating that they are in an obscured state. Figure 8The lines connecting the central hole and the rectangular frame represent pipelines. Hole 1a connects to the discharge flow path 6, hole 1b connects to the outlet of the premixer 8, hole 1c connects to the synthesis container 9, hole 1d connects to the gas source 7, and hole 1e connects to one inlet of the two-position three-way valve 10. The feed flow path 5 connects to the other inlet of the two-position three-way valve 10, and the outlet of the two-position three-way valve 10 connects to the inlet of the premixer 8. These connections form a complete solid-phase synthesis reaction system. The gas source 7 supplies inert gas, such as nitrogen. Purging the premixer 8 and synthesis container 9 with inert gas is a crucial step in the solid-phase synthesis reaction. The inert gas removes residual reagents from the premixer 8 and synthesis container 9, achieving a cleaning effect to facilitate the synthesis reactions of different types of reagents. The three connection states of the flow path switching valve allow for individual purging of the premixer 8, individual purging of the synthesis container 9, and simultaneous purging of both premixers 8 and synthesis container 9. Figure 9 As shown, the flow path switching valve is in its first state. At this time, slot 22 is connected to holes 1c and 1d, allowing gas source 7 to input gas into the synthesis container 9. Slot 21 is only connected to hole 1a. At this time, no flow path is formed between other components, and the gas can only purge the synthesis container 9 along the flow path from holes 1c to 1d. The hollow arrows in the diagram represent the gas flow direction. Figure 10 As shown, the flow path switching valve is in the second state. At this time, slot 21 is connected to holes 1a and 1b, and slot 22 is connected to holes 1d and 1e. The gas input from gas source 7 enters the two-position three-way valve 10 through hole 1e. The two-position three-way valve 10 is open. At this time, the pipeline from feed flow path 5 to the two-position three-way valve 10 is in a closed state. The gas enters the premixer 8 through the inlet and blows out the waste material inside the premixer 8. The waste material enters hole 1a through hole 1b, and then enters the discharge flow path 6 from hole 1a, completing the individual purging of the premixer 8. Figure 11 As shown, slot 21 connects to holes 1b and 1c, and slot 22 connects to end A2 and hole 1e. Gas input from gas source 7 enters end A2 through hole 1d, then from end A2 to hole 1e, and from hole 1e through two-position three-way valve 10 into the inlet of premixer 8, blowing out the waste material in premixer 8. The waste material enters hole 1c through hole 1b, and finally is blown into synthesis container 9, purging synthesis container 9 as well. Therefore, three purging conditions can be achieved by using the flow path switching valve.

[0044] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims. Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A flow path switching valve, comprising a stator and a rotor, wherein the connecting end face of the rotor and the connecting end face of the stator are sealed and fitted together and are rotatable relative to each other, characterized in that, At least five flow holes are provided on the connecting end face of the stator, and each flow hole penetrates the outer wall of the other end of the stator to form a component connection hole. The connecting end face of the stator is also provided with a stator groove, and one end of the stator groove communicates with one of the flow holes. A first rotor slot and a second rotor slot are formed on the connecting end face of the rotor. By rotating the rotor, one of multiple communication states between the first rotor slot and the second rotor slot and the flow hole and stator slot can be achieved. The multiple communication states include: In the first connected state, the first rotor slot or the second rotor slot connects two adjacent flow holes; In the second connected state, both the first rotor slot and the second rotor slot are directly connected to two adjacent flow holes; In the third connected state, the first rotor slot is directly connected to two adjacent flow holes, and the second rotor slot is indirectly connected to two adjacent flow holes by connecting to the stator slot.

2. The flow path switching valve according to claim 1, characterized in that, The flow holes include a first flow hole, a second flow hole, a third flow hole, a fourth flow hole, and a fifth flow hole. The first flow hole, the second flow hole, the third flow hole, the fourth flow hole, and the fifth flow hole are sequentially distributed on a circumference with the center of the connecting end face as the center and a radius of R1. The rotation axis of the rotor passes perpendicularly through the center of the connecting end face. The other end of the stator slot and all ends of the first rotor slot and the second rotor slot are also arranged on this circumference.

3. A flow path switching valve according to claim 2, characterized in that, In the first connected state, the first rotor slot or the second rotor slot is connected to the adjacent third flow hole and fourth flow hole.

4. A flow path switching valve according to claim 2, characterized in that, In the second connected state, the first rotor slot is directly connected to the adjacent first flow hole and second flow hole, and the second rotor slot is directly connected to the adjacent fourth flow hole and fifth flow hole.

5. A flow path switching valve according to claim 2, characterized in that, In the third connected state, the first rotor slot is directly connected to the adjacent second and third flow holes, one end of the second rotor slot is connected to the fifth flow hole, the other end of the second rotor slot is connected to the other end of the stator slot, and the second rotor slot is indirectly connected to the adjacent fourth and fifth flow holes by connecting the stator slot.

6. A flow path switching valve according to claim 2, characterized in that, The hole spacing between each of the flow holes and the nearest other flow hole is equal, the distance between the other end of the stator slot and the nearest flow hole is consistent with the hole spacing, and the distance between the two ends of the first rotor slot and the second rotor slot is consistent with the hole spacing.

7. A flow path switching valve according to claim 6, characterized in that, The slot width at the end of the stator slot, the slot width at the end of the first rotor slot and the second rotor slot, and the diameter of the flow hole are all the same.

8. A flow path switching valve according to claim 7, characterized in that, The ends of the first rotor slot and the second rotor slot are also distributed on a circumference with radius R1 centered on the center of the connecting end face, and there is a gap between the adjacent ends of the first rotor slot and the second rotor slot.

9. A solid-phase synthesis reaction system, characterized in that, The device includes the flow path switching valve as described in any one of claims 1-8, and further includes a feed flow path, a discharge flow path, an air source, a premixer, and a synthesis container. The inlet of the premixer is connected to a component connection hole and the outlet of the feed flow path, respectively. The component connection hole connected to the air source corresponds to the flow hole of the stator slot. In the third connected state, the two adjacent flow holes connected to the first rotor slot correspond to a component connection hole connected to the synthesis container and a component connection hole connected to the premixer outlet, respectively. The two adjacent flow holes connected to the second rotor slot correspond to a component connection hole connected to the premixer inlet and a component connection hole connected to the gas source, respectively. The discharge flow path is connected to a component connection hole.

10. The solid-phase synthesis reaction system according to claim 9, characterized in that, A two-position three-way valve is installed at the inlet of the premixer. One of the control components, the two-position three-way valve, and the feed flow path outlet are connected to the inlet of the premixer.

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