Application of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3, 3-dimethyl-2-butanone to prevention and control of plant diseases

Abstract

The invention discloses application of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3, 3-dimethyl-2-butanone to prevention and control of plant diseases, indoor toxicity determination and field efficacy verification prove that the 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3, 3-dimethyl-2-butanone has good inhibitory activity on plant pathogenic fungi, and the 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3, 3-dimethyl-2-butanone can be applied to prevention and control of plant diseases, so that the 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3, 3-dimethyl-2-butanone can be applied to prevention and control of plant diseases. The bactericidal composition also has excellent prevention and treatment effects on plant fungal diseases, can be alternately used with conventional bactericides, and is used for resistance treatment of the plant fungal diseases.

Description

Technical Field

[0001] This invention belongs to the field of fungicides, specifically relating to the use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the control of plant diseases. Background Technology

[0002] 1-(4-Chlorophenoxy)-1-(1-Imidazolyl)-3,3-dimethyl-2-butanone can specifically inhibit fungal cytochrome P45014α-demethylase (CYP51), blocking ergosterol biosynthesis, leading to cell membrane structure destruction and cell death. It has inhibitory effects on fungi such as Malassezia furfur and Candida albicans, as well as some bacteria, and is particularly effective against fungi that cause dandruff. Therefore, it is used in the manufacture of anti-dandruff shampoos, antibacterial soaps, shower gels, and medicated toothpastes.

[0003] Currently, the control of agricultural plant diseases mainly relies on chemical control. However, long-term use of single pesticides has led to the continuous improvement of pathogen resistance. Reports indicate that powdery mildew fungi, downy mildew fungi, and rust fungi have developed high resistance to triazole fungicides, methoxyacrylate fungicides, and succinate dehydrogenase inhibitor fungicides, respectively. This increasing pathogen resistance leads to decreased pesticide efficacy, thereby affecting yields and causing economic losses. Summary of the Invention

[0004] The purpose of this invention is to provide the use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the control of plant diseases. This invention has experimentally verified that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone exhibits good inhibitory activity against plant pathogenic fungi. 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, as a fungicide, can meet the requirements for chemical control of plant diseases.

[0005] The technical solution of the present invention is as follows: The use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the control of plant diseases, wherein the plant diseases are those caused by plant pathogenic fungi.

[0006] Preferably, the plant pathogenic fungi are fungi of the Ascomycota, Basidiomycota, or Oomycetes.

[0007] Preferably, the Ascomycota fungi include the genera *Powdery mildew*, *Anthracis*, and *Fusarium*; the Basidiomycota fungi include the orders *Ruscidales* and *Ustilagoes*; and the Oomycetes fungi include the genera *Peronospora*, *Pseudomonas*, *Monocotyle*, *Plasmodium*, and *Phytophthora*.

[0008] More preferably, the Ascomycota fungi belong to the genus *Erysiphe*; the Basidiomycota fungi belong to the order *Ruscidales*; and the Oomycetes fungi belong to the genera *Peronospora*, *Pseudomonospora*, *Monocotyle*, and *Platycotyle*.

[0009] Preferably, the plants include cereal crops, tuber crops, legume crops, fruit trees, vegetables, flowers, and tobacco.

[0010] More preferably, the plants include wheat, corn, sorghum, potato, soybean, strawberry, cucumber, tomato, grape, lettuce, cabbage, melon, apple, pear, rose, Chinese rose, chrysanthemum, and tobacco.

[0011] Preferably, the plant diseases include powdery mildew, downy mildew, and rust.

[0012] A bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, wherein the bactericide comprises 0%~100% of the active ingredient 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone by weight percentage.

[0013] Preferably, the bactericide contains 20% to 60% of the active ingredient 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone by weight percentage.

[0014] More preferably, the bactericide contains 40% by weight of the active ingredient 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone.

[0015] Preferably, the bactericide further includes excipients selected from one or more of solvents, emulsifiers, dispersants, thickeners, stabilizers, antifreeze agents, defoamers, pH adjusters, film-forming agents, warning colors, capsule wall materials, and carriers.

[0016] Preferably, the fungicide can be formulated into any agriculturally permissible formulation.

[0017] Preferably, the dosage form includes suspension concentrates, wettable powders, water-dispersible granules, dispersible oil suspensions, microcapsule suspensions, emulsifiable concentrates, water-in-oil emulsions, microemulsions, and seed treatment agents.

[0018] The fungicide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone is used for the prevention and control of plant fungal diseases.

[0019] Preferably, the plant fungal diseases are powdery mildew, downy mildew, and rust.

[0020] The beneficial effects of this invention are: 1. This invention provides a novel use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the prevention and control of plant fungal diseases.

[0021] 2,1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone has excellent control effects against powdery mildew, downy mildew and rust. Alternating its use with conventional fungicides can effectively slow down the development of resistance. Detailed Implementation

[0022] To enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below with reference to specific embodiments. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] Unless otherwise specified, the experimental methods used in the following examples are conventional methods.

[0024] Unless otherwise specified, all raw materials and reagents used in the following examples are commercially available.

[0025] Indoor toxicity test Test target: wheat powdery mildew fungus ( Blumeria grassinis ), cucumber downy mildew fungus ( Pseudoperonospora cubensis ), wheat leaf rust pathogen ( Puccinia confida ).

[0026] Test reagent: 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone.

[0027] Test methods: The tests were conducted in accordance with the agricultural industry standards of the People's Republic of China issued by the Ministry of Agriculture of the People's Republic of China, NY / T1156.4—2006 and NY / T1156.15—2008.

[0028] The technical grade 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone was dissolved in acetone and diluted according to the pre-experimental concentration gradient for later use.

[0029] wheat powdery mildew Using a pot cultivation method, wheat (Huaimai 33) seedlings were prepared when they reached the 2-3 leaf stage. Fresh spores of powdery mildew produced on diseased wheat leaves within 24 hours were evenly shaken off and inoculated onto the potted wheat seedlings. Each treatment was replicated 4 times, with 10 seedlings per pot. 24 hours after inoculation, different concentrations of the fungicide were sprayed onto the wheat seedlings using a spraying method. The seedlings were then allowed to air dry naturally and placed in an artificial climate chamber for incubation and observation. The treatment without the fungicide served as a blank control.

[0030] Efficacy survey: The disease incidence of the blank control was graded as follows: Grade 0, no disease; Grade 1, lesion area less than 5% of the total leaf area; Grade 3, lesion area 6% to 15% of the total leaf area; Grade 5, lesion area 16% to 25% of the total leaf area; Grade 7, lesion area less than 26% to 50% of the total leaf area; Grade 9, lesion area more than 50% of the total leaf area.

[0031] Data statistics: Based on the survey data, the disease index and prevention and control effect of each treatment were calculated. The disease index and prevention and control effect formulas are shown below: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Prevention and control effect (%) = (disease index of blank control - disease index of drug treatment / disease index of blank control) × 100.

[0032] EC of each reagent was calculated using SPSS 18. 50 Values ​​and regression equations.

[0033] cucumber downy mildew Using the pot cultivation method, wait until the cucumber (Xintai Dense Thorn) seedlings have grown to the 4-6 leaf stage before use. Wash off the downy mildew spores from the underside of the leaves with distilled water and prepare a suspension (concentration controlled at 1×10⁻⁶ per ml). 5 ~1×10 7 (1 spore), sprayed onto the leaves for inoculation. 24 hours after inoculation, the solution was evenly sprayed onto the underside of the leaves. After the solution was allowed to air dry naturally, the leaves were placed in an artificial climate chamber and cultured under conditions of continuous 12-hour light / dark cycles per day, at a temperature of 20℃ and a relative humidity of over 90%. Each treatment consisted of 5 pots with 2 plants per pot, and the experiment was repeated 4 times. A treatment without the solution was included as a blank control.

[0034] Efficacy survey: The disease incidence of the blank control was graded as follows: Grade 0, no disease; Grade 1, lesion area less than 5% of the total leaf area; Grade 3, lesion area 6% to 10% of the total leaf area; Grade 5, lesion area 11% to 25% of the total leaf area; Grade 7, lesion area less than 26% to 50% of the total leaf area; Grade 9, lesion area more than 50% of the total leaf area.

[0035] Data statistics: Based on the survey data, the disease index and prevention and control effect of each treatment were calculated. The disease index and prevention and control effect formulas are shown below: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Prevention and control effect (%) = (disease index of blank control - disease index of drug treatment / disease index of blank control) × 100.

[0036] EC of each reagent was calculated using SPSS 18. 50 Values ​​and regression equations.

[0037] Wheat leaf rust Ten plants were grown in each pot until the wheat (Huai Mai 33) reached the two-leaf, one-heart stage. Fresh urediniospores of the rust fungus produced within 24 hours of diseased leaves were washed off with a 0.1% Tween 80 aqueous solution and filtered through two layers of gauze to prepare 1×10⁻⁶ spores. 5 Prepare a suspension of spores / mL for later use. Inoculate the wheat seedlings using a spray solution. After inoculation, place the seedlings in the dark and humidified environment at 20℃ for 12 hours, then place them in an artificial climate chamber for continuous 12-hour light / dark cycle daily. 24 hours after inoculation, spray the solution evenly over the leaves until completely wet. After the solution air-dries naturally, continue culturing in the artificial climate chamber for observation. Each treatment consists of 2 pots, repeated 4 times, with the treatment without the solution serving as a blank control.

[0038] Efficacy survey: Based on the disease incidence of the blank control, a graded survey was conducted using the following grading method: Grade 0, no spore heaps; Grade 1, spore heaps occupy less than 5% of the total leaf area; Grade 3, spore heaps occupy 5% to 10% of the total leaf area; Grade 5, spore heaps occupy 10% to 25% of the total leaf area; Grade 7, spore heaps occupy 25% to 50% of the total leaf area; Grade 9, spore heaps occupy more than 50% of the total leaf area.

[0039] Data statistics: Based on the survey data, the disease index and prevention and control effect of each treatment were calculated. The disease index and prevention and control effect formulas are shown below: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Prevention and control effect (%) = (disease index of blank control - disease index of drug treatment / disease index of blank control) × 100.

[0040] EC of each reagent was calculated using SPSS 18. 50 Values ​​and regression equations.

[0041] Table 1. Results of toxicity assays

[0042] Note: In the regression equation, the logarithmic value of the drug concentration (x) is the independent variable, and the probability value of the control effect (y) is the dependent variable.

[0043] The above results indicate that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone has a good inhibitory effect on wheat powdery mildew pathogen, cucumber downy mildew pathogen, and wheat leaf rust pathogen, and can be used for the prevention and control of these three diseases.

[0044] Formulation preparation example Example 1 40% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, 3% lignin sulfonate, 7% EO-PO block copolymer, 0.1% xanthan gum thickener, 0.1% BIT preservative, 3% ethylene glycol, 0.2% silicone defoamer, deionized water to 100%.

[0045] The above raw materials were placed in a reaction vessel according to the formula ratio, water was added and mixed evenly, and after high-speed shearing, wet sand milling, and finally homogenization and filtration, 40% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone suspension was obtained.

[0046] Example 2 30% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, 2% phosphate ester dispersant, 2% EO-PO block copolymer, 0.1% xanthan gum thickener, 0.1% BIT preservative, 3% ethylene glycol, 0.2% silicone defoamer, deionized water to 100%.

[0047] The above raw materials were placed in a reaction vessel according to the formula ratio, water was added and mixed evenly, and after high-speed shearing, wet sand milling, and finally homogenization and filtration, 30% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone suspension was obtained.

[0048] Example 3 50% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, 5% carboxylate polymer, 6% EO-PO block copolymer, 0.1% xanthan gum thickener, 0.1% BIT preservative, 3% ethylene glycol, 0.2% silicone defoamer, deionized water to 100%.

[0049] The above raw materials were placed in a reaction vessel according to the formula ratio, water was added and mixed evenly, and after high-speed shearing, wet sand milling, and finally homogenization and filtration, 50% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone suspension was obtained.

[0050] Example 4 60% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, 5% sodium polycarboxylate, 5% sodium alkylnaphthalene sulfonate, 3% ammonium sulfate, 1% polyvinylpyrrolidone, bentonite to make up to 100%.

[0051] The active ingredient is added to the carrier according to the formula ratio, and other auxiliary agents are added to it. After mixing, the mixture is pulverized by air jet and 10-25% water is added. After kneading, granulation, drying and sieving, 60% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone water-dispersible granules are obtained.

[0052] Example 5 20% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, 15% solvent oil, 10% cyclohexanone, 8% carboxylate dispersant, 2% fatty alcohol polyoxyethylene ether, 0.1% xanthan gum, 2% toluene diisocyanate, 1% PEG400, 4% ethylene glycol, 0.1% BIT preservative, 2% silicone defoamer, deionized water to 100%.

[0053] The active ingredient, solvent, and emulsifier were dispersed at high speed to form an emulsion according to the above ratio, and then slowly added dropwise to the prepolymer aqueous solution. The capsule shell monomer was added, and after solidification, microcapsules were formed. The remaining adjuvants were added to finally obtain 20% 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone microcapsule suspension.

[0054] Field efficacy trial of pesticides for wheat powdery mildew Test reagent: Example 1, 430 g / L tebuconazole SC (PD20132142).

[0055] The crop tested was wheat (Huai Mai 33).

[0056] Test target: Wheat powdery mildew ( Blumeria grassinis ).

[0057] Test location: Cheqiao Town, Huai'an City, Jiangsu Province.

[0058] Experimental design: The experiment was conducted in accordance with GB / T17980.22-2000. A total of 5 treatments were set up, with each treatment replicated 4 times. The plot area was 30 m². 2 The plots were randomly arranged, with protective rows between plots. At the early stage of wheat powdery mildew, an electric sprayer was used to evenly spray the upper and lower surfaces of the leaves, using 45 L / acre of water. The specific design for each treatment is as follows: Table 2. Treatment agents and dosages

[0059] Efficacy survey: A five-point sampling method was used to investigate the disease severity of wheat plants at each point, 10 plants per point, and the flag leaf and the first leaf below the flag leaf were selected from each plant. The disease severity grading standards are as follows: Grade 0, no disease; Grade 1, lesion area less than 5% of the total leaf area; Grade 3, lesion area 6%–15% of the total leaf area; Grade 5, lesion area 16%–25% of the total leaf area; Grade 7, lesion area less than 26%–50% of the total leaf area; Grade 9, lesion area more than 50% of the total leaf area.

[0060] The efficacy of the pesticide was calculated based on the survey data, using the following formula: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Control efficacy (%) = (1 - Disease index before treatment in blank control × Disease index after treatment / Disease index after treatment in blank control × Disease index before treatment) × 100.

[0061] As shown in the table below, all treatments exhibited significant control effects against wheat powdery mildew. Specifically, the control efficacy of treatment in Example 1 increased with increasing dosage of the active ingredient, which was 150 g / hm². 2 The highest control efficacy was achieved at this time, reaching 98.74%. These results indicate that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone has excellent control effects against wheat powdery mildew and can be used for the prevention and control of wheat powdery mildew.

[0062] Table 3 Field control efficacy against wheat powdery mildew

[0063] Field efficacy trial of herbicides for cucumber downy mildew Test reagent: Example 1, 50% dimethomorph SC (PD20152095).

[0064] Test crop: Cucumber (Xintai Dense Thorn).

[0065] Test target: cucumber downy mildew ( Pseudoperonospora cubensis ).

[0066] Test location: Xintai City, Tai'an City, Shandong Province.

[0067] Experimental design: The experiment was conducted in accordance with GB / T17980.26-2000. A total of 5 treatments were set up, with each treatment replicated 4 times. The area of ​​each plot was 20 m². 2 The cells were randomly arranged, with protective rows between cells. At the early stage of downy mildew, an electric sprayer was used for uniform spraying, with a water consumption of 45L / acre. The specific design of each treatment is as follows: Table 4. Treatment agents and dosages

[0068] Efficacy survey: A five-point sampling method was used, with 5 plants at each point and 2 leaves per plant. Disease severity was assessed before and 7 days after application of the pesticide. The grading standards are as follows: Grade 0, no disease; Grade 1, lesions covering less than 5% of the total leaf area; Grade 3, lesions covering 6% to 10% of the total leaf area; Grade 5, lesions covering 11% to 25% of the total leaf area; Grade 7, lesions covering less than 26% to 50% of the total leaf area; Grade 9, lesions covering more than 50% of the total leaf area.

[0069] The efficacy of the pesticide was calculated based on the survey data, using the following formula: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Control efficacy (%) = (1 - Disease index before treatment in blank control × Disease index after treatment / Disease index after treatment in blank control × Disease index before treatment) × 100.

[0070] As shown in the table below, all treatments showed a certain degree of control over cucumber downy mildew. Specifically, the control efficacy of treatment in Example 1 increased with increasing dosage of the active ingredient, which was 100 g / hm². 2 The concentration was 65.82%, lower than the 69.16% of the dimethomorph treatment; when the effective ingredient dosage in Example 1 reached 200 g / hm. 2 At this time, the control efficacy reached its maximum, at 84.64%, which was superior to that of dimethomorph treatment. These results indicate that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone can be used to control cucumber downy mildew.

[0071] Table 5 Field control efficacy against cucumber downy mildew

[0072] Field efficacy trial of wheat leaf rust Test reagent: Example 1, 430 g / L tebuconazole SC (PD20132142).

[0073] The crop tested was wheat (Huai Mai 33).

[0074] Test target: Wheat leaf rust ( Puccinia confida ).

[0075] Test location: Pingqiao Town, Huai'an City, Jiangsu Province.

[0076] Experimental design: The experiment was conducted in accordance with GB / T17980.23-2000. A total of 5 treatments were set up, with each treatment replicated 4 times. The plot area was 30 m². 2The cells were randomly arranged, with protective rows between cells. At the initial stage of leaf rust disease, an electric sprayer was used for uniform spraying, with a water consumption of 45 L / acre. The specific design for each treatment is as follows: Table 6. Treatment agents and dosages

[0077] Efficacy survey: A five-point sampling method was used, with 10 plants at each point and the top 3 leaves of each plant selected. Disease severity was assessed before and 14 days after application of the pesticide. The grading standards are as follows: Grade 0, no disease; Grade 1, lesions cover less than 5% of the total leaf area; Grade 3, lesions cover 6% to 25% of the total leaf area; Grade 5, lesions cover 26% to 50% of the total leaf area; Grade 7, lesions cover 51% to 75% of the total leaf area; Grade 9, lesions cover more than 76% of the total leaf area.

[0078] The efficacy of the pesticide was calculated based on the survey data, using the following formula: Disease index = (∑(number of diseased leaves at each level × relative level value) / total number of leaves surveyed × 9) × 100; Control efficacy (%) = (1 - Disease index before treatment in blank control × Disease index after treatment / Disease index after treatment in blank control × Disease index before treatment) × 100.

[0079] As shown in the table below, all treatments exhibited good control efficacy against wheat leaf rust. Specifically, the control efficacy of treatment in Example 1 increased with increasing dosage of the active ingredient, which was 150 g / hm². 2 The concentration reached its highest level at 96.05%, which was superior to the tebuconazole treatment. These results indicate that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone can be used to control wheat leaf rust.

[0080] Table 7 Field control efficacy of wheat leaf rust

[0081] This invention provides a novel application of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the control of plant fungal diseases. Experimental verification shows that 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone exhibits good control effects against wheat powdery mildew, cucumber downy mildew, and wheat leaf rust. Therefore, 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone can be used for the control of plant fungal diseases and can be used in rotation with conventional fungicides to delay the development of plant disease resistance.

[0082] Although embodiments of the invention have been disclosed for illustrative purposes, those skilled in the art will understand that various substitutions, variations, and modifications are possible without departing from the spirit and scope of the invention and the appended claims, and therefore the scope of the invention is not limited to the contents disclosed in the embodiments.

Claims

The use of 1,1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone for the control of plant diseases, characterized in that... The plant diseases mentioned are those caused by plant pathogenic fungi.

2. The use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 1 for the control of plant diseases, characterized in that, The plant pathogenic fungi are fungi belonging to the Ascomycota, Basidiomycota, and Oomycetes.

3. The use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 2 for the control of plant diseases, characterized in that, The Ascomycota fungi include the genera *Erysinomycetes*, *Anthracis*, and *Fusarium*. The phylum Basidiomycota fungi include the order Rust Fungi and the order Ustilago; The Oomycetes include the genera *Peronospora*, *Pseudomonospora*, *Monocotyle*, *Plasmodium*, and *Phytophthora*.

4. The use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 1 for the control of plant diseases, characterized in that, The plants mentioned include cereal crops, tuber crops, legume crops, fruit trees, vegetables, flowers, and tobacco.

5. The use of 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 1 for the control of plant diseases, characterized in that, The plant diseases mentioned include powdery mildew, downy mildew, and rust.

6. A bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone, characterized in that, The bactericide contains, by weight percentage, 0% to 100% of the active ingredient 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone.

7. The bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 6, characterized in that, The bactericide contains 20% to 60% of the active ingredient 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone by weight percentage.

8. The bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 6, characterized in that, The bactericide also includes excipients selected from one or more of the following: solvents, emulsifiers, dispersants, thickeners, stabilizers, antifreeze agents, defoamers, pH adjusters, film-forming agents, warning colors, capsule wall materials, and carriers.

9. The bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 6, characterized in that, The fungicide can be formulated into any agriculturally permissible formulation.

10. The bactericide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 9, characterized in that, The formulations include suspension concentrates, wettable powders, water-dispersible granules, dispersible oil suspensions, microcapsule suspensions, emulsifiable concentrates, water-in-oil emulsions, microemulsions, and seed treatment agents.

11. The use of the fungicide containing 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone as described in claim 6 for the prevention and control of plant fungal diseases.

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