Fragrance composition for relieving mood of children as well as preparation method and application of fragrance composition

Abstract

The invention relates to a fragrance composition for relieving mood of children as well as a preparation method and application of the fragrance composition. The fragrance composition is prepared from the following components in percentage by weight: 40 to 60 percent of methyl dihydrojasmonate, 30 to 50 percent of brazyl acid glycol cyclic ester, 1 to 10 percent of terpinyl dihydroacetate, 1 to 10 percent of tetrahydrolinalool and 1 to 5 percent of methyl cedryl ketone. Compared with the prior art, the emotional soothing fragrance has universality (can be used for cosmetics of various dosage forms), the emotional soothing effect is achieved by reducing the heart rate, breath and the like used by children, meanwhile, the brain wave alpha / beta power is improved, and the soothing and nerve soothing effect is achieved.

Description

Technical Field

[0001] This invention belongs to the field of cosmetics and personal care, specifically relating to a children's mood-soothing fragrance composition, its preparation method, and its application. Background Technology

[0002] Modern research shows that mood swings and stress responses are increasingly common among children. Traditional interventions mainly rely on behavioral therapy or even medication, but medication can have side effects, and behavioral therapy requires professional guidance and takes a long time to take effect. Therefore, non-pharmacological, natural, and gentle methods of mood relief are extremely important for children.

[0003] Aromatherapy, as an ancient treatment method, has a long history of providing relaxation and soothing effects through the use of aromatherapy or the addition of fragrances to cosmetics. The perception of olfactory / tactile input is an important aspect of subjective experience, and research has shown that the use of scented skincare products can alter the emotional perception and related physiological activities of adult female volunteers.

[0004] Studies have shown that the sense of smell is primarily located in the frontal and temporal lobes of the brain. Its mechanism of action may involve inhaled aromatic molecules triggering activity in related brain regions along the olfactory pathway, thereby regulating cognitive abilities and emotional responses. The neurosoothing effects of fragrances are mainly due to two factors: First, fragrances act on the emotional brain. In the brain, the olfactory center and memory center are closely connected. When people inhale fragrances, these aromatic chemical molecules awaken memories stored in the memory center, stimulate the limbic system, activate the amygdala, and generate specific emotions. Second, odor molecules stimulate the release of neurotransmitters, increase blood flow to the prefrontal cortex, and help improve depressive states. Emotions affect vital signs such as respiration, heart rate, and blood pressure, and also influence electroencephalogram (EEG) power spectra. EEG power spectra are divided into different frequency bands, primarily γ (30-40Hz), β (13-30Hz), α (8-13Hz), θ (4-8Hz), and δ (0.5-4Hz). The α and β bands are particularly important in emotion research. α brain waves typically appear when people are relaxed, calm, or meditating with their eyes closed, while β brain waves are associated with alertness, active thinking, and focused attention. As important indicators of emotional state, α and β brain waves can be effectively understood by modulating their activity through aromatherapy, thus revealing their regulatory role in emotions.

[0005] The olfactory neurons in a fetus develop very early, and the fetus can smell odors starting around the 20th week of pregnancy. Smell provides infants with their first impressions of their social and living environment and is an important source of sensory stimulation. For infants and toddlers, specific scents can, to some extent, reduce their behavioral and physiological arousal, such as having a calming and sleep-inducing effect, aiding growth, and soothing their mood.

[0006] Patent CN202210907430.6 discloses a fragrance composition comprising dipropylene glycol, musk T, methyl dihydrojasmonate, ethyl vanillin, sandalwood 803, and leucopicrin. These components work synergistically to activate the dopamine pathway, positively impacting human behavior, physiology, and psychology. Furthermore, this fragrance can inhibit the release of stress biomarkers such as α-amylase and cortisol under stress. However, this formulation lacks specific formulation design and safety verification tailored to the unique physiological characteristics of children. Its "activation of the dopamine pathway" efficacy is based on general population studies, without specific verification considering the developmental stages of children's nervous and endocrine systems. It also fails to take into account children's higher skin permeability and immature metabolic systems, and does not optimize the dosage and compatibility of the components.

[0007] There are few fragrance blends specifically designed for children's emotional responses, and this issue is often overlooked. Therefore, there is an urgent need for fragrances that specifically soothe children's emotions. Summary of the Invention

[0008] The purpose of this invention is to provide a children's mood-soothing fragrance composition, its preparation method, and its application, which can soothe a child's emotions, allow the child to fully relax, and enhance their sense of happiness and self-confidence.

[0009] The objective of this invention can be achieved through the following technical solution: a children's mood-soothing fragrance composition, comprising the following components by weight percentage: methyl dihydrojasmonate 40-60%, ethylene glycol cyclic brassinolate 30-50%, terpineol dihydroacetate 1-10%, tetrahydrolinalool 1-10%, and methyl cedrol 1-5%.

[0010] Further, the composition comprises the following components in weight percentage: methyl dihydrojasmonate 45-60%, ethylene glycol cyclic brassinolate 30-45%, terpineol dihydroacetate 1-8%, tetrahydrolinalool 1-6%, and methyl cedrol 1-4%.

[0011] Further, the composition comprises the following components in weight percentage: methyl dihydrojasmonate 48-60%, ethylene glycol cyclic brassinolate 30-45%, terpineol dihydroacetate 1-5%, tetrahydrolinalool 2-6%, and methyl cedrol 1-4%.

[0012] This invention also relates to a method for preparing a children's mood-soothing fragrance composition, wherein methyl dihydrojasmonate, ethylene glycol cyclic brassinolate, terpineol dihydroacetate, tetrahydrolinalool, and methyl cedrol are mixed and stirred, then sealed and aged to allow impurities to fully precipitate, then cooled under certain conditions, then filtered, and finally restored to room temperature to obtain a clear and transparent fragrance composition.

[0013] Preferably, the mixing temperature is 20-40℃, for example, 20℃, 25℃, 30℃, 35℃, 40℃, etc., the mixing speed is 10-100r / min, for example, 10r / min, 20r / min, 30r / min, 40r / min, 50r / min, 60r / min, 70r / min, 80r / min, 90r / min, 100r / min, etc., and the mixing time is 30-60min, for example, 30min, 35min, 40min, 45min, 50min, 55min, 60min, etc.

[0014] Furthermore, the sealing and aging temperature is 10-20℃, for example, it can be 10℃, 12℃, 14℃, 16℃, 18℃, 20℃, etc., and the sealing and aging time is 5-7 months, for example, it can be 5 months, 5.5 months, 6 months, 6.5 months, 7 months, etc.

[0015] Furthermore, the cooling temperature is -5~0℃, for example, it can be -5℃, -4℃, -3℃, -2℃, -1℃, etc., and the cooling time is 20-40min, for example, it can be 20min, 25min, 30min, 35min, 40min, etc.

[0016] Furthermore, the filtration uses a filter membrane with a pore size of 0.05-0.5μm (e.g., 0.05μm, 0.1μm, 0.2μm, 0.3μm, 0.4μm, 0.5μm, etc.).

[0017] The present invention also relates to the application of a children's mood-soothing fragrance composition, wherein the composition is used in children's toiletries.

[0018] Furthermore, the children's personal care products include shampoo, shower gel, face cream, or body cream.

[0019] Furthermore, the composition is added to the children's toiletries in an amount of 0.01-5% by weight, preferably 0.05-4%, and more preferably 0.1-3%.

[0020] Compared with the prior art, the present invention has the following beneficial effects: This invention utilizes methyl dihydrojasmonate, glycol cyclic brassinolate, terpineol dihydroacetate, tetrahydrolinalool, and methyl cedrol to create a synergistic effect, resulting in a layered and pleasant fragrance that does not cause discomfort. Methyl dihydrojasmonate is widely used in the fragrance and flavor industry, possessing a blend of fresh floral and citrus aromas, a combination that may evoke feelings of pleasure. Some studies suggest that citrus aromas have a relaxing and invigorating effect, while floral scents are typically associated with soothing and gentle emotions. Glycol cyclic brassinolate has a predominantly creamy and fruity aroma, associated with feelings of security and comfort, easily triggering associations with safety and attachment, thus helping to alleviate anxiety. Terpineol dihydroacetate's olfactory characteristics are typically associated with sensory associations of forests and natural environments; this type of aroma is believed to bring a refreshing and tranquil feeling, helping to relieve tension. Tetrahydrolinalool, a hydrogenated derivative of linalool, possesses a soft floral fragrance. Linalool molecules can produce calming and anti-anxiety effects by regulating the central nervous system (GABA receptors), thus it is speculated that tetrahydrolinalool can provide a gentle and lasting soothing effect in fragrance compositions. Methyl cedryne has a deep woody aroma. Woody aromas are generally associated with stable, safe, and calming sensory experiences in olfactory psychology. This invention utilizes the above five key odor molecules to form a complementary synergy through different odor characteristics and potential neuropsychological pathways: methyl dihydrojasmonate provides a pleasant and positive feeling; ethylene glycol cyclic ester of brassinolate brings a sense of security and attachment; terpineol dihydroacetate creates a fresh and peaceful atmosphere; tetrahydrolinalool achieves a gentle calming effect; and methyl cedryne provides a deep and stable base note. Through this layered aroma profile and multi-pathway synergy, the fragrance composition of this invention can effectively achieve a gradual soothing effect on children's emotions, from excitement to relaxation and from tension to stability, thereby enhancing the overall emotional calming experience.

[0021] (2) The methyl dihydrojasmonate used in this invention is naturally found in jasmine essential oil. It has a rich sweet floral fragrance with a hint of fruit and jasmine, and a fresh and soft lemon-like fruity aroma, which enhances the "gentleness" of the overall fragrance and balances the sharpness or intensity of other ingredients, so as to avoid children being rejected by the overly strong smell. The ethylene glycol cycloester of brassinolate (musk T) has a warm powdery and creamy fragrance with a slight amber and soapy feel. The fragrance is round and long-lasting. The terpineol dihydroacetic acid has a fresh pine needle fragrance as the main component, with a slight citrus (lemon) and woody notes. The fragrance is light and transparent. The soft floral fragrance (similar to tuberose) and sweet orange blend of tetrahydrolinalool avoids the fragrance from being too "heavy" and is more in line with children's preference for "light and natural" smells. The warm woody fragrance (cedar) of methyl cedarone is the main component and the fragrance is calm.

[0022] (3) The above-mentioned composition used in this invention is safe and does not contain 26 kinds of allergenic fragrances. It can be used safely by children, soothe the baby's emotions, allow the baby to fully relax, and enhance the baby's sense of happiness and self-confidence. Attached Figure Description

[0023] Figure 1 The image shows an EEG analysis diagram, where BL is the baseline, T5min refers to 5 minutes after use, and T10min refers to 10 minutes after use. Detailed Implementation

[0024] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. These embodiments are based on the technical solution of the present invention and provide detailed implementation methods and specific operating procedures. However, the scope of protection of the present invention is not limited to the following embodiments.

[0025] The following detailed description is provided through specific embodiments and comparative examples. Unless otherwise specified, the raw materials used in this invention are all commercially available products.

[0026] Examples 1-4 The children's mood-soothing fragrance compositions provided in Examples 1-4 are composed of the following raw material components by weight percentage: The above fragrance compositions were prepared by the following method: Methyl dihydrojasmonate, ethylene glycol cyclic brassinolate, terpineol dihydroacetate, tetrahydrolinalool, and methyl cedrol were weighed in sequence according to the above proportions and placed in a reactor. The mixture was stirred at 30°C for 30 min at a stirring speed of 50 r / min. The mixture was then sealed and aged at 15°C for 6 months to allow impurities to fully precipitate. The mixture was then cooled to -4°C for 30 min. After filtration through a 0.1 μm filter membrane, the mixture was restored to room temperature to obtain the clear and transparent fragrance compositions of each embodiment.

[0027] Comparative Examples 1-30 and Blank Examples Comparative Examples 1-10 provide fragrance compositions, which are composed of the following raw material components by weight percentage, and are prepared by the same method as in Example 1:

[0028] Safety Testing: Throughout the recruitment and research process, this study strictly adhered to the ethical guidelines of the Declaration of Helsinki of the World Medical Association to ensure the legality, ethical conduct, and scientific rigor of the research. All experimental groups added 1% to the face cream, followed by human patch testing; no abnormalities were observed after the tests.

[0029] Stability test: After adding it to the face cream at a concentration of 1%, and then subjecting it to high and low temperatures and light exposure, no significant changes in fragrance, cloudiness, discoloration, or precipitation were observed, indicating that it has good stability.

[0030] Characterization data and effect data of the products in the examples and comparative examples Subjects: This study included 210 volunteers aged 9-12 years, with 6 people in each group for heart rate and respiratory rate testing.

[0031] Test product: The compositions obtained from Examples 1-4, Comparative Examples 1-30, and the blank control were added to a children's face cream (Ailebeibei face cream was used in this test), and the composition accounted for 0.1% of the face cream by mass. Test method: Volunteers in each group used face creams containing the compositions obtained in Examples 1-4, Comparative Examples 1-30, and the blank control example, applying 1g of face cream to their face. Heart rate, respiratory rate, and electroencephalogram (EEG) were measured after 10 minutes.

[0032] Testing equipment: Heart rate is detected using a Physiolab ECG sensor, which captures the weak surface voltage difference generated by the electrical activity of the heart muscle through three electrodes (positive, negative, and ground) attached to the skin; respiratory rate is detected using a Physiolab breathing belt sensor, an elastic band that wraps around the chest and abdomen and contains a strain-sensitive element. The expansion and contraction of the chest cavity during respiration causes the breathing belt to stretch and contract, resulting in a regular change in the inductance of the sensitive element. This physical deformation is converted into a corresponding electrical signal, which, after processing, reflects the respiratory rate.

[0033] The test results are as follows: (1) Heart rate analysis It stimulates sympathetic nerve activity, promotes adrenaline secretion, and enhances alertness, but may cause a temporary increase in heart rate and blood pressure. A significant decrease in heart rate indicates that the test product can reduce autonomic arousal levels, making the individual calmer.

[0034] Calculate the heart rate variability (%) for each group of test subjects using the following formula: Heart rate variability = (Heart rate after use - Heart rate before use) / Heart rate before use × 100% As can be seen from the table above, there was no significant change in the heart rate of the subjects before and after the test in the blank control group. Both the control group and the example group could reduce the heart rate of the subjects, but the improvement rate of the example group was more significant, reducing the heart rate by about 20%. The effects of the control examples 1-30, which contained only one or more of the components, were not as good as those of examples 1-4. This indicates that the composition of the present invention can be fully combined and has a synergistic effect, further reducing the heart rate and achieving a mood-relieving effect.

[0035] (2) Respiratory rate analysis Calculate the rate of change (%) of respiratory rate for each group of test subjects using the following formula: Rate of change in respiratory rate = (Respiratory rate after use - Respiratory rate before use) / Respiratory rate before use × 100% As can be seen from the table above, there was no significant change in respiratory rate before and after the test in the blank control group. Both the control group and the example group reduced the respiratory rate of the subjects, but the improvement rate of the example group was more significant, with a maximum reduction in heart rate of 12.5%. The effects of the control examples 1-30, which contained only one or more of the components, were not as good as those of examples 1-4. This indicates that the composition of this patent can work together effectively and has a synergistic effect, further reducing respiratory rate and achieving a mood-soothing effect.

[0036] (3) Electroencephalogram (EEG) analysis The experimental procedure was as follows: This study included 26 volunteers aged 9-12 years. After using a face cream containing the composition obtained in Example 2, brain waves were detected using the Emotiv Epoc X EEG acquisition system. Specifically, the electrode sponge pads were thoroughly soaked with the included saline solution. The device was then worn on the head, and the electrode arms were adjusted to the target scalp position, ensuring close contact between the sponge pads of all 14 electrodes and the scalp. The device was powered on, the EmotivPRO software was run, and the device was connected. Recording began after all or most electrode channels showed good signals.

[0037] The power spectrum of electroencephalography (EEG) is divided into different frequency bands, mainly γ (30-40Hz), β (13-30Hz), α (8-13Hz), θ (4-8Hz), and δ (0.5-4Hz). Among them, the α and β bands are particularly important in emotion research. Alpha brain waves usually appear when people are in a relaxed, calm, or meditative state with their eyes closed, while β brain waves are associated with alertness, active thinking, and focused attention. As important indicators of emotional state, α and β brain waves can be effectively modulated by aromatherapy to understand their regulatory role in emotion. Experimental results are as follows Figure 1 As shown in the figure: from red to blue, the α / β power ratio increases. The significant increase in both the α / β power ratio and the sample's stamina indicates a shift in the volunteers' brain state towards greater stability and relaxation. This shift may be related to the fragrance of the test product and its longevity. Example 2 was selected as the key observation sample, and changes in the subjects' electroencephalograms (EEGs) after product use were detected. The results showed that the α / β power was significantly higher after product use than before, further demonstrating the mood-soothing effect of the fragrance composition of this invention.

[0038] The applicant declares that the above embodiments illustrate the fragrance composition, its preparation method, and its application, but the present invention is not limited to the above process steps, i.e., it does not mean that the present invention must rely on the above process steps to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of the raw materials used in the present invention, addition of auxiliary components, and selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. A child mood soothing fragrance composition characterized in that, The composition comprises the following components by weight percentage: 40-60% of methyl dihydrojasmonate, 30-50% of ethylene brassylate, 1-10% of dihydroterpineol acetate, 1-10% of tetrahydrolinalool, and 1-5% of methyl cedrylone.

2. A child mood soothing fragrance composition according to claim 1, wherein The composition comprises the following components by weight percentage: 45-60% of methyl dihydrojasmonate, 30-45% of ethylene brassylate, 1-8% of dihydroterpineol acetate, 1-6% of tetrahydrolinalool, and 1-4% of methyl cedrylone.

3. The child mood soothing fragrance composition of claim 1, wherein, The composition comprises the following components by weight percentage: 48-60% of methyl dihydrojasmonate, 30-45% of ethylene brassylate, 1-5% of dihydroterpineol acetate, 2-6% of tetrahydrolinalool, and 1-4% of methyl cedrylone.

4. A method for preparing a children's mood-soothing fragrance composition according to any one of claims 1-3, characterized in that, The methyl dihydrojasmonate, ethylene brassylate, dihydroterpineol acetate, tetrahydrolinalool, and methyl cedrylone are mixed and stirred, and then sealed and aged to allow impurities to fully precipitate, and then cooled under certain conditions, and then filtered, and then returned to room temperature to obtain the clear and transparent fragrance composition.

5. The method for preparing the children's mood-soothing fragrance composition according to claim 4, characterized in that, The sealing and aging temperature is 10-20°C, and the sealing and aging time is 5-7 months.

6. The method of claim 4, wherein the child mood soothing fragrance composition is prepared by the steps of: The cooling temperature is -5-0°C.

7. The method of claim 4, wherein the child mood soothing fragrance composition is prepared by mixing the fragrance composition and the carrier in a ratio of 1: 1 to 1:

10. The filtration uses a filter membrane with a pore size of 0.05-0.5 μm.

8. The application of the children's mood-soothing fragrance composition as described in claim 1, characterized in that, The composition is used in children's washing and care products.

9. Use of a child mood soothing fragrance composition according to claim 8, characterized in that, The children's washing and care products include shampoo, shower gel, face cream, or body cream.

10. Use of a child mood soothing fragrance composition according to claim 8, wherein The weight addition amount of the composition in the children's washing and care products is 0.01-5%.

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