Facial anti-aging essence based on composite plant extract and preparation method of facial anti-aging essence

Abstract

The invention belongs to the technical field of cosmetics, and discloses a facial anti-aging essence based on a composite plant extract and a preparation method of the facial anti-aging essence. According to the essence, plant extracts of matricaria recutita, glycyrrhiza glabra, centella asiatica, rosemary, scutellaria baicalensis, green tea and polygonum cuspidatum, butyrospermum parkii butter and tocopherol are selected, a synergistic anti-aging system is constructed with an extremely low addition amount, and the comprehensive effects of resisting inflammation and oxidation, promoting collagen generation and inhibiting elastase are achieved through the multi-target effect. Fullerene, hydroxyl pinacolone retinoate and acetyl hexapeptide-8 are further introduced, so that the firming and anti-wrinkle effects are remarkably improved. The essence disclosed by the invention has good tightening and anti-wrinkle performance and sensitive skin applicability, is stable in structure, safe and mild, and is suitable for daily face anti-aging nursing.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of cosmetics, and particularly relates to a facial anti-aging essence based on composite plant extracts and a preparation method thereof. BACKGROUND

[0002] Skin aging is a process of multiple factors synergistically acting, mainly manifested as phenomena of decreased elasticity, deepened wrinkles, loose skin and lost luster. Elastic fibers constitute an important basis of skin elasticity in the dermis, mainly composed of elastin and microfibrils, which can maintain the tension and elasticity of the skin. However, external stimulating factors such as ultraviolet radiation, environmental pollution and stress can accelerate the degradation process of elastin, thereby leading to decreased skin elasticity and structural rupture, which is a direct inducement of photoaging and formation of loose wrinkles. Studies have shown that elastin is prone to selective decomposition mediated by proteases under ultraviolet induction. Persistent degradation of elastin not only causes decreased skin elasticity, but also exacerbates collagen loss and thinning of the epidermis, thereby inducing sensitive, wrinkled and loose skin problems. Therefore, finding a mild skin care ingredient that can effectively inhibit elastase activity has become an important direction of anti-aging research.

[0003] Currently, commercially available facial anti-aging products mostly use single functional ingredients such as retinol and peptides, but there are problems such as single efficacy target, strong irritation and unsuitability for sensitive skin. At the same time, the mechanism research on plant extracts synergistically inhibiting elastase and achieving anti-wrinkle and anti-loose is still in the exploratory stage, especially the research on constructing a multi-target synergistic anti-aging system under the condition of low dose safety is less. SUMMARY

[0004] To solve the problems mentioned in the background, the purpose of the present application is to provide a facial anti-aging essence based on composite plant extracts and a preparation method thereof, which combines the plant extracts of mother chrysanthemum, licorice, centella asiatica, rosemary, radix scutellariae, green tea and giant knotweed, and the shea butter and tocopherol, constructs a multi-target synergistic anti-aging system by combining fullerene, hydroxy phthalyl trianilide and acetyl hexapeptide-8, and realizes the effects of inhibiting elastase, antioxidant and promoting collagen generation.

[0005] The purpose of the present application can be achieved by the following technical solutions:

[0006] A facial anti-aging essence based on composite plant extracts, comprising the following components in percentage by mass: filler 71-78%, emollient 14-18%, skin conditioning agent 1.5-2.1%, coloring agent 0.4-0.6%, antioxidant 0.4-0.6%, humectant 0.0005-0.002%, and plant-derived active substance 0.0005-0.002%.

[0007] The plant-derived active substances comprise the following mass percentage components: avocado tree butter 95-98%, mother chamomile extract 0.5-1.5%, liquorice root extract 0.3-0.7%, gotu kola extract 0.3-0.7%, rosemary leaf extract 0.05-0.15%, tocopherol 0.05-0.15%, radix scutellariae extract 0.001%, tea leaf extract 0.001%, radix polygoni multiflori extract 0.001%;

[0008] The skin conditioning agent comprises the following components and their mass percentages in the total essence: pearl powder 0.9-1.4%, isosorbide dimethyl ether 0.42-0.48%, hydroxy pinnacine retinoate 0.03-0.07%, hydrogenated polyisobutene 0.08-0.10%, fullerene 0.00003-0.00004%, carnosine 0.0005-0.0015%, acetyl hexapeptide-8 0.0005-0.0015%.

[0009] Further preferably, the filler comprises the following components and their mass percentages in the total essence: dimethicone 32-36%, dimethicone crosspolymer 10-11%, cyclopentasiloxane 30-31%.

[0010] Further preferably, the emollient comprises one or more of isononyl isononanoate, cyclopentasiloxane, and cyclohexasiloxane.

[0011] Further preferably, the coloring agent comprises one or more of CI 77891, aluminum hydroxide, dimethicone, CI 77492, isononyl isononanoate, polyhydroxy stearic acid, and triethoxycaprylylsilane.

[0012] Further preferably, the antioxidant is tocopheryl acetate; and the humectant is sodium hyaluronate.

[0013] Further preferably, the facial anti-aging essence further comprises the component rose flower oil 0.01-0.03%.

[0014] A preparation method of a facial anti-aging essence based on composite plant extracts, comprising the following steps:

[0015] S1. Sterilize the used grinding machine, emulsifying pot, stirring device and related tools in sequence, rinse them with sterile pure water, and keep them dry for use;

[0016] S2. Weigh the components of phase A: emollient, C20-24 alkyl dimethicone, pearl powder, CI 77891, aluminum hydroxide, dimethicone, antioxidant, and rose flower oil, and grind them finely with a grinding machine;

[0017] S3. Weigh the B phase components and add them to the emulsifying pot: fillers, skin conditioners except pearl powder, CI 77492, isononyl isononanoate, polyhydroxy stearic acid, triethoxyl octyl silane, plant-derived active substances, humectants, start stirring, stirring speed about 22 Hz, stir evenly;

[0018] S4. Slowly add the A phase to the B phase system, continue stirring while adding, until fully dispersed and uniform, check the system stability and uniformity, pass the inspection, discharge;

[0019] S5. Take samples for testing, after the semi-finished product passes the inspection, fill the containers;

[0020] S6. Prepare the corresponding inner packaging materials, fill the containers, prepare the corresponding outer packaging materials after the inspection, package the filled products, produce the finished products, and obtain the facial anti-aging essence.

[0021] Further preferably, the essence can be used to inhibit facial skin relaxation and wrinkle formation caused by elastase activity, and is suitable for facial anti-aging care scenarios.

[0022] The beneficial effects of the present application are:

[0023] The present application realizes mild, safe and significant facial firming skin care function by constructing a multi-target synergistic anti-aging system based on composite plant extracts. A variety of plant-derived extracts such as mother chamomile, liquorice, gotu kola, rosemary, radix scrophulariae, green tea and giant knotweed are compounded in a very low amount, covering multiple action paths such as anti-inflammatory, antioxidant, collagen synthesis promotion and elastase inhibition, not only effectively delaying the degradation of dermal matrix, but also improving the skin's own repair ability. The action targets of plant extracts are complementary, avoiding functional redundancy while enhancing synergistic effect, so that the present application has systematic anti-aging ability while ensuring the adaptability of sensitive skin. On this basis, the present application further introduces hydroxyl pinacolone retinoate, fullerene and acetyl hexapeptide-8, which synergistically improves the overall firming and anti-wrinkle effect through mechanisms such as free radical scavenging, enzyme degradation inhibition and collagen synthesis promotion. The elastase inhibition experiment verifies that the inhibition rate of the essence sample of the present application on elastase reaches more than 25%, which is significantly better than the blank control group, indicating that it has a significant elastin protection effect. BRIEF DESCRIPTION OF DRAWINGS

[0024] The present application will be further described below with reference to the accompanying drawings.

[0025] Figure 1 The bar chart for the elastase inhibition rate of the essence of the inventive examples and comparative examples;

[0026] Figure 2 The bar chart for the DPPH clearance rate of the essence of the inventive examples and comparative examples. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work are within the protection scope of the present application.

[0028] The balance not listed in the present application can be the allowable carrier, such as purified water, emollient, emulsifying aid, balanced to 100%, and the raw materials used are commercially available conventional grades, and the preparation process is carried out under clean conditions.

[0029] Embodiment 1

[0030] The facial anti-aging essence provided by the present application specifically comprises the following components:

[0031]

[0032] Embodiment 2

[0033] The facial anti-aging essence provided by the present application specifically comprises the following components:

[0034]

[0035] Embodiment 3

[0036] The facial anti-aging essence provided by the present application specifically comprises the following components:

[0037]

[0038] The preparation method of the facial anti-aging essence based on the composite plant extract according to any one of Embodiments 1-3 specifically comprises the following steps:

[0039] S1. The equipment and tools used are sterilized in advance, then washed clean with sterile pure water, and dried;

[0040] S2. A phase is weighed and finely ground by a grinder;

[0041] S3. B phase is weighed and added to an emulsifying pot, stirring is started, the stirring speed is about 22 Hz, and stirring is uniform;

[0042] S4. A phase is slowly added to the B phase system, stirring is continued while adding, until the system is fully dispersed and uniform, the stability and uniformity of the system are tested, and the product is discharged after passing the test;

[0043] S5. Sampling and testing are performed, and the semi-finished product is filled after passing the test;

[0044] S6. Prepare the corresponding inner packaging material, fill, and test. After passing the test, prepare the corresponding outer packaging material, package the filled product, and obtain the facial anti-aging essence.

[0045] Comparative Example 1

[0046] The facial anti-aging essence provided by the present application specifically comprises the following components:

[0047]

[0048] The preparation steps of the facial anti-aging essence are the same as in the example.

[0049] Comparative Example 2

[0050] The facial anti-aging essence provided by the present application specifically comprises the following components:

[0051]

[0052] The preparation steps of the facial anti-aging essence are the same as in the example.

[0053] Performance test

[0054] 1. Elastase inhibition experiment

[0055] In a 96-well plate, add 90 μL of Tris-HCl buffer, 30 μL of essence sample diluent, and 10 μL of substrate (n-succ-(ALa)-3-pnitroanilide). After mixing, incubate at 25°C for 20 minutes, then add 20 μL of porcine pancreatic elastase solution, and incubate at 25°C for 10 minutes. Measure the absorbance at 410 nm wavelength, with deionized water instead of the sample as the negative control. Calculate the inhibition rate, and the results are shown in Table 1 below.

[0056] Table 1 Elastase inhibition rate results

[0057]

[0058] As shown in Table 1, the elastase inhibition rates of Examples 1-3 are 27.8%, 28.3%, and 28.5% respectively, which are significantly higher than those of Comparative Examples 1 and 2, and much higher than that of the negative control group (0.48%). The results show that the composite plant extract and the triple active enhancement system used in the application have a good synergistic effect, which can effectively inhibit the activity of elastase at a low dose, thereby reducing the degradation of elastin and playing a firming and anti-wrinkle effect. After removing the plant-derived active substances in Comparative Example 1, the inhibition rate is greatly reduced to 14.8%, indicating that various plant components play a key role in enzyme inhibition and anti-aging; after removing the triple active enhancement components in Comparative Example 2, the inhibition rate is further reduced to 10.2%, indicating that such components are also indispensable for free radical scavenging and collagen protection enhancement.

[0059] 2. DPPH free radical scavenging experiment

[0060] A 0.1 mmol·L⁻¹ DPPH (1,1-diphenyl-2-trinitrophenylhydrazine)-methanol solution was prepared, 200 μL of the solution was added to each reaction well of a 96-well enzyme plate, and 20 μL of an aqueous diluent of different samples was added, and then mixed thoroughly. After being placed in the dark for 30 minutes to ensure sufficient reaction, the absorbance (A s ) of each well was measured at a wavelength of 517 nm after the reaction was completed. Deionized water was used instead of the sample diluent as the negative control group (A0) for reference, and the scavenging rate was calculated according to the following formula:

[0061]

[0062] The results are shown in Table 2 below.

[0063] Table 2 DPPH free radical scavenging rate

[0064]

[0065] As shown in Table 2, the DPPH free radical scavenging rates of Examples 1-3 are all more than 68%, which are significantly better than those of Comparative Examples 1 and 2. The natural antioxidant components in the plant extract added in the application provide basic scavenging ability, while fullerene has a unique cage structure and can stably adsorb and scavenge free radicals. Hydroxyl pinacolone retinol can regulate the oxidation-reduction balance of skin cells, and acetyl hexapeptide-8 can indirectly reduce oxidative stress by regulating the release of neurotransmitters.

[0066] 3. Skin irritation test

[0067] To evaluate the skin irritation of the essence of this invention, a human patch test was used for verification. Thirty healthy volunteers were selected, and samples from Examples 1-3, Comparative Examples 1 and 2 were respectively added to closed patches and applied to undamaged areas of the back for 24 hours. After removing the patches, local reactions such as erythema, papules, and edema were observed and recorded at 0h, 24h, and 48h. Reactions were assessed according to the international standard scoring system (Grade 0: no reaction; Grade 1: mild erythema; Grade 2: significant erythema or papules; Grade 3: severe reaction). The results are shown in Table 3 below.

[0068] Table 3 Results of Skin Irritation Test

[0069]

[0070] As shown in Table 3, the average score of Examples 1-3 was 0.1, indicating that the essence of this invention has almost no skin irritation, good safety, and is suitable for people with sensitive skin. Comparative Examples 1 and 2, however, scored 0.6 and 0.3 respectively, both showing slight irritation, indicating that the mildness of the formula decreased after removing some core active ingredients. This invention uses low amounts of various plant extracts to construct a mild, multi-target anti-aging system, supplemented with fullerene, hydroxypinazone retinate, and acetyl hexapeptide-8, which improves the stability of the active substances and skin tolerance, thus maintaining extremely low irritation while achieving effective anti-aging.

[0071] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0072] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed invention.

Claims

1. A facial anti-aging essence based on compound plant extracts, characterized in that, It contains the following components by weight percentage: filler 71-78%, emollient 14-18%, skin conditioning agent 1.5-2.1%, colorant 0.4-0.6%, antioxidant 0.4-0.6%, moisturizer 0.0005-0.002%, and plant-derived active substances 0.0005-0.002%; The plant-derived active substances comprise the following components by weight percentage: shea butter 95-98%, chamomile extract 0.5-1.5%, licorice root extract 0.3-0.7%, centella asiatica extract 0.3-0.7%, rosemary leaf extract 0.05-0.15%, tocopherol 0.05-0.15%, scutellaria baicalensis root extract 0.001%, tea extract 0.001%, and polygonum cuspidatum root extract 0.001%. The components of the skin conditioning agent and their percentage by weight in the total essence are as follows: pearl powder 0.9-1.4%, isosorbide dimethyl ether 0.42-0.48%, hydroxypinazone retinate 0.03-0.07%, hydrogenated polyisobutylene 0.08-0.10%, fullerene 0.00003-0.00004%, carnosine 0.0005-0.0015%, and acetyl hexapeptide-8 0.0005-0.0015%.

2. The facial anti-aging essence according to claim 1, characterized in that, The components of the filler and their percentage of the total mass of the essence are as follows: polydimethylsiloxane 32-36%, polydimethylsiloxane cross-linked polymer 10-11%, and cyclopentadimethylsiloxane 30-31%.

3. The facial anti-aging essence according to claim 1, characterized in that, The emollient contains one or more of isononyl isononanoate, cyclopentamethoxysiloxane, and cyclohexylsiloxane.

4. The facial anti-aging essence according to claim 1, characterized in that, The colorant comprises one or more of CI 77891, aluminum hydroxide, polydimethylsiloxane, CI 77492, isononyl isononanoate, polyhydroxystearic acid, and triethoxyoctylsilane.

5. The facial anti-aging essence according to claim 1, characterized in that, The antioxidant is tocopheryl acetate; the moisturizer is sodium hyaluronate.

6. The facial anti-aging essence according to claim 1, characterized in that, The facial anti-aging serum also contains 0.01-0.03% rose oil.

7. A method for preparing a facial anti-aging essence based on compound plant extracts, wherein the facial anti-aging essence is as described in any one of claims 1-6, characterized in that, Includes the following steps: S1. Sterilize the grinding machine, emulsifying pot, stirring device and other equipment and related tools used in sequence, rinse them with sterile pure water, and keep them dry before use; S2. Weigh out the components of phase A: emollient, C20-24 alkyl polydimethylsiloxane, pearl powder, CI 77891, aluminum hydroxide, polydimethylsiloxane, antioxidant, and rose oil, and grind them finely using a grinder; S3. Weigh out the B phase components and add them to the emulsifying pot: filler, skin conditioning agent (excluding pearl powder), CI 77492, isononyl isononanoate, polyhydroxystearic acid, triethoxyoctylsilane, plant-derived active substances, and moisturizer. Turn on the stirring and stir at a speed of about 22 Hz until the mixture is homogeneous. S4. Slowly add phase A to phase B while stirring continuously until fully dispersed and uniform. Check the stability and uniformity of the system. Discharge the material after it passes the test. S5. Sampling and testing; after the semi-finished product passes inspection, it is then filled. S6. Prepare the corresponding inner packaging materials, fill the product, and after inspection, prepare the corresponding outer packaging materials. Package the filled product to produce the finished product and obtain the facial anti-aging essence.

8. The facial anti-aging essence according to claim 1, characterized in that, The essence can be used to inhibit facial skin sagging and wrinkle formation caused by elastase activity, and is suitable for facial anti-aging care.

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