Macrocyclic compounds and antibody-drug conjugates thereof

Abstract

Provided are a macrocyclic compound and an antibody-drug conjugate thereof, specifically, the macrocyclic compound is a targeted RAS protein inhibitor. The invention also provides a preparation method of the macrocyclic compound and the antibody-drug conjugate thereof, and application of the macrocyclic compound and the antibody-drug conjugate thereof in medicine.

Description

Macrocyclic compounds and antibody-drug conjugates thereof

[0001] This application is based on the CN application number 202311147514.5 with a filing date of September 6, 2023, the CN application number 202410956050.0 with a filing date of July 16, 2024, the CN application number 202311569777.5 with a filing date of November 22, 2023, the CN application number 202311720542.1 with a filing date of December 13, 2023, and the CN application number 202410021 309.2 with an application date of January 5, 2024, the application with CN application number 202410177985.9 with an application date of February 8, 2024, the application with CN application number 202410365458.0 with an application date of March 27, 2024, and the application with CN application number 202410687961.8 with an application date of May 29, 2024 as basis, and claim their priority, the disclosed contents of the aforementioned CN applications are hereby introduced as a whole into this application. Technical Field

[0002] The present disclosure belongs to the field of biomedicine, and specifically relates to a macrocyclic compound and an antibody-drug conjugate thereof. The macrocyclic compound is a targeted RAS protein inhibitor. The present disclosure also relates to the use of the macrocyclic compound and the antibody-drug conjugate thereof in the treatment of diseases. Background Art

[0003] Antibody-drug conjugates are antibodies or antibody fragments linked to active toxic drugs via chemical linkers. They can fully utilize the specificity of antibodies for binding to tumor cell surface antigens and the high efficiency of active toxic drugs in killing tumor cells, while simultaneously overcoming the shortcomings of low efficacy of antibodies alone and large toxic side effects of toxic drugs. Currently, a variety of antibody-drug conjugates have been approved both domestically and internationally, such as gemtuzumab ozogamicin approved by the FDA and vedicizumab (trade name: ). Currently, there are also a large number of antibody-drug conjugates in clinical development.

[0004] The RAS gene (Rat sarcoma viral oncogene homolog) encodes a family of small GTP hydrolase proteins with a molecular weight of approximately 21 kDa. The mammalian RAS family includes three members: HRAS, KRAS, and NRAS. They function as molecular switches in the signaling pathways of various cellular pathways. When bound to GDP, RAS is in a dormant or inactive state. When cells are exposed to certain growth-promoting stimuli, RAS is induced to exchange the bound GDP for GTP, thereby becoming activated. It then recruits and activates other downstream target proteins (such as Raf and PI3K), promoting cell proliferation. RAS proteins inherently have the ability to hydrolyze GTP to GDP (thus converting themselves to an inactive state), but the conversion rate is low. However, when bound to GTPase-activating proteins (GAPs), the interaction greatly accelerates the rate at which RAS proteins convert GTP to GDP. This allows RAS to quickly return to its inactive state upon termination of cellular stimulation, shutting down signaling pathways.

[0005] Approximately 30% of human tumors harbor RAS gene mutations; KRAS mutations are the most common, accounting for approximately 85%, followed by NRAS and HRAS at 12% and 3%, respectively. KRAS mutations are predominant in pancreatic cancer (86%), colorectal cancer (41%), and lung cancer (32%). NRAS mutations are more common in melanoma and acute myeloid leukemia, and HRAS mutations are more common in bladder cancer and head and neck cancer. In tumors, RAS gene mutations primarily occur through point mutations. Over 150 different RAS point mutations have been identified, with mutations at positions G12 and G13, as well as Q61, being the most common. These pathogenic mutations typically affect the interaction between RAS and GAP and the endogenous GTP hydrolase activity of RAS, resulting in the mutant RAS protein being primarily present in the GTP-bound, activated form within the cell. This results in the RAS protein maintaining a persistently activated signaling pathway, leading to uncontrolled cell proliferation and ultimately promoting tumor formation.

[0006] Currently, the targeted drugs AMG510 and MRTX849 have been approved for the treatment of KRAS G12C mutation-positive non-small cell lung cancer. However, there are no approved targeted drugs for KRAS G12D and KRAS G12V mutations, which are common in pancreatic cancer and colorectal cancer, or NRAS and HRAS mutations, which are common in melanoma and head and neck cancer, leaving a large unmet clinical need.

[0007] Currently, RMC-6236, a pan-RAS inhibitor targeting multiple RAS mutations and RAS wild-type tumors, is in Phase I clinical trials. Preliminary clinical trial results show that it has some efficacy in lung cancer and pancreatic cancer patients harboring mutations such as KRAS G12D and KRAS G12V, but also exhibits significant skin toxicity. This toxicity is presumed to be due to the inhibitory effect of pan-RAS inhibitors on normal skin tissue cells. If pan-RAS inhibitors are conjugated to antibodies via linkers, the specificity of antibodies in targeting tumor cells and the high efficiency of RAS inhibitors can be fully utilized, and the toxic side effects on normal tissue cells can be reduced or avoided. This means that compared with pan-RAS inhibitors, antibody-conjugated pan-RAS inhibitors can precisely target tumor cells and reduce the impact on non-tumor cells, which is expected to increase the therapeutic window and enhance the safety of pan-RAS inhibitors.

[0008] Therefore, the development of highly effective inhibitors targeting multiple RAS mutations and their antibody conjugates has important clinical value and is also a hot topic and difficulty in the field of new drug research and development.

[0009] Summary of the Invention

[0010] This application relates to an antibody-drug conjugate, a linker-drug, and a macrocyclic compound. Experiments have shown that the antibody-drug conjugate of this application has excellent cytostatic and tumor-suppressing effects; the compound of this application has excellent protein binding, cytostatic effects, liver microsomal stability, solubility, and hydrophilicity. This application also relates to pharmaceutical compositions comprising the antibody-drug conjugate or compound, and the use of the antibody-drug conjugate, compound, or pharmaceutical composition in the preparation of a medicament for the treatment, prevention, and / or treatment of diseases or conditions associated with RAS protein activity.

[0011] Antibody-drug conjugates

[0012] The first aspect of the present invention provides an antibody-drug conjugate represented by formula (I):

[0013] Ab is an antibody or fragment thereof that binds to the target;

[0014] n is 1 to 20 and can be an integer or a non-integer;

[0015] D is a fragment targeting RAS protein inhibitor;

[0016] L0 is a linker connecting Ab and D.

[0017] In one embodiment, is a structure represented by Formula (VI-1), Formula (VI-2), Formula (VI-3), Formula (VI-4), Formula (VI-5) or Formula (VI-6) or a stable deuterated derivative thereof, or a stereoisomer thereof,

[0018] in,

[0019] In formula (VI-1), formula (VI-2), formula (VI-3), formula (VI-4), and formula (VI-5), the structural unit for X is

[0020] In formula (VI-6), the structural unit for X is or,

[0021] Structural unit for X is

[0022] The end is connected to L0, and the * end is connected to other fragments in D.

[0023] When L0 is connected to D, the hydrogen atom on D is replaced by L0, or the N atom on D is quaternized;

[0024] Y1 and Y2 are each independently N, CH, or CR 4a , CR 4b or CYj4, where N can be oxidized (N + -O - );

[0025] Z4, Z5, and Z6 are each independently N, CR 13 , CR 14 , CR 48 , CR 49 or CR 50 ;

[0026] R 13 and R 14 are each independently hydrogen, halogen, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl or -P(=O)-(C 1-6 alkyl)2, or

[0027] R 13 and R 14Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1 3-6 cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0028] R 48 、R 49 、R 50 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0029] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0030] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, or -P(=O)-(C 1-6 Alkyl) 2, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl are optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0031] R 4a for C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3- to 8-membered heterocyclyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0032] Yj3 is NH-Rj 6 、O-Rj 6 NRj 62 Rj 6 、-C 1-4 Alkylene-NH-Rj 6 、-C 1-4Alkylene-NRj 62 Rj 6 、-C 1-4 Alkylene-O-Rj 6 ;

[0033] Rj 6 is hydrogen or C 1-6 alkyl;

[0034] Rj 62 is hydrogen or C 1-6 alkyl;

[0035] Rj 61 C 1-6 alkyl;

[0036] R 4b is deuterium, halogen, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl or C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 heteroalkyl;

[0037] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1- 4-alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1- 4-alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group, C 6-10 aryl, 5 or 6-membered monocyclic heteroaryl or 8 to 10-membered bicyclic heteroaryl, the 3 to 8-membered monocyclic heterocyclic group, 5 to 15-membered tricyclic heterocyclic group, 7 to 12-membered bicyclic heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0038] R 01 、R 02 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl or (C 1-6 Alkyl) 3-Si-, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, or,

[0039] R 01 、R 02Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclic group, a 7- to 12-membered bicyclic heterocyclic group, or a 3- to 8-membered monocyclic heterocyclic group, wherein the 5- to 15-membered tricyclic heterocyclic group, the 7- to 12-membered bicyclic heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, or,

[0040] R 01 、R 02 Jointly formed Among them, R 001 、R 002 Together with the sulfur atom to which it is attached, it forms a 3- to 8-membered monocyclic heterocyclic group optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0041] R 03 、R 04 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, the C 1-6 Alkyl, C 1- 6 alkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6, or

[0042] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0043] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0044] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0045] Y4 is O or S;

[0046] Y5 is O or S;

[0047] is a single bond or a double bond;

[0048] R m1 、R m3 Not present or hydrogen, R m2 is hydrogen, R m4 、R m5 are each independently hydrogen, halogen or C 1-6 Alkyl; or

[0049] R m1 With R m2 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;or,

[0050] R m1 With R m3 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;or,

[0051] R m1 With R m4 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;

[0052] R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl;

[0053] L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0054] Y 10 is a bond, O, NH or N(C 1-4 alkyl);

[0055] R 00 is hydrogen or C 1-6 alkyl;

[0056] Rj 21 For hydrogen, deuterium, halogen, hydroxyl, amino, C 1-6 Alkyl, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Heteroalkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g ;

[0057] Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Heteroalkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g ;

[0058] Rj f is hydrogen or C 1-6 alkyl;

[0059] Rj g is hydrogen or C 1-6 alkyl;

[0060] Rj 11 and Rj 12 Each is independently hydrogen, halogen or C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl; or

[0061] Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1 3-6 cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0062] R 44 、R 45 、R 46 、R 47 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0063] Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ;

[0064] Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0065] or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, wherein one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0066] Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, heteroaryl, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, heteroaryl are optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0067] R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0068] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl; the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0069] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0070] or R 07 and R 08 Together with the atoms to which it is attached, it forms a 3- to 8-membered heterocyclyl group optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0071] In the above groups, S1 is independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , SF5, halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Heteroalkyl, C 3- 20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Heteroalkylene-C 1-4 Heteroalkylene-C 1-6 Heteroalkylene, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1- 4-alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1- 4-alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NRa1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by one or more (eg, 1, 2, or 3) groups selected from halogen, deuterium, cyano, hydroxyl, or amino; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by one or more (e.g., 1, 2, 3, or 4) groups selected from Group S2; the nitrogen atom in the 5- or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O - );

[0072] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(O)H, -C(O)-C 1-4 Alkylene-OH, -C(=O)-C 3-6 monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group, -C(=O)-5 to 8-membered heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the 5 to 8 membered heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by one or more (e.g., 1 or 2) groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 Alkyl)2, -C(O)C 1-6 Alkyl, -C(O)OC 1-6 Alkyl, -P(=O)-(C 1-6 alkyl)2; or

[0073] Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0074] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0075] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0076] In the above groups, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0077] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 alkyl)2, -(C=O)OC 1-6 Alkyl, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0078] In the above groups, the -C 1-4Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0079] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0080] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0081] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0082] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0083] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0084] In one embodiment, is a structure represented by Formula (VI-1), Formula (VI-2), Formula (VI-3), Formula (VI-4), Formula (VI-5) or Formula (VI-6) or a stable deuterated derivative thereof, or a stereoisomer thereof,

[0085] in,

[0086] Structural unit for X is or,

[0087] Structural unit for X is

[0088] The end is connected to L0, and the * end is connected to other fragments in D.

[0089] When L0 is connected to D, the hydrogen atom on D is replaced by L0, or the N atom on D is quaternized;

[0090] Y1 and Y2 are each independently N, CH, or CR 4a , CR 4b or CYj4, where N can be oxidized (N + -O - );

[0091] Z4, Z5, and Z6 are each independently N, CR 13 , CR 14 , CR 48 , CR 49 or CR 50 ;

[0092] R 13 and R 14 are each independently hydrogen, halogen, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl or -P(=O)-(C 1-6 alkyl)2, or

[0093] R 13 and R 14 Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1 3-6 cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0094] R 48 、R 49 、R 50 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0095] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0096] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, or -P(=O)-(C 1-6 Alkyl) 2, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl are optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0097] R 4a for C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3- to 8-membered heterocyclyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0098] Yj3 is NH-Rj 6 、O-Rj 6 NRj 62 Rj 6 、-C 1-4 Alkylene-NH-Rj 6 、-C 1-4 Alkylene-NRj 62 Rj 6 、-C 1-4 Alkylene-O-Rj 6 ;

[0099] Rj 6 is hydrogen or C 1-6 alkyl;

[0100] Rj 62 is hydrogen or C 1-6 alkyl;

[0101] Rj 61 C 1-6 alkyl;

[0102] R 4b is deuterium, halogen, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl or C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 heteroalkyl;

[0103] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1- 4-alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1- 4-alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04), 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group, C 6-10 aryl, 5 or 6-membered monocyclic heteroaryl or 8 to 10-membered bicyclic heteroaryl, the 3 to 8-membered monocyclic heterocyclic group, 5 to 15-membered tricyclic heterocyclic group, 7 to 12-membered bicyclic heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0104] R 01 、R 02 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl or (C 1-6 Alkyl) 3-Si-, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, or,

[0105] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclic group, a 7- to 12-membered bicyclic heterocyclic group, or a 3- to 8-membered monocyclic heterocyclic group, wherein the 5- to 15-membered tricyclic heterocyclic group, the 7- to 12-membered bicyclic heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, or,

[0106] R 01 、R 02 Jointly formed Among them, R 001 、R 002 Together with the sulfur atom to which it is attached, it forms a 3- to 8-membered monocyclic heterocyclic group optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0107] R 03 、R 04 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, the C 1-6 Alkyl, C 1- 6 alkoxy, C 2-6 Alkenyl or C 2-6Alkynyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6, or

[0108] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0109] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0110] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0111] Y4 is O or S;

[0112] Y5 is O or S;

[0113] is a single bond or a double bond;

[0114] R m1 、R m3 Not present or hydrogen, R m2 is hydrogen, R m4 、R m5 are each independently hydrogen, halogen or C 1-6 Alkyl; or

[0115] R m1 With R m2 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;or,

[0116] R m1 With R m3 Connect to form-CR m7 R m6 -or-CR m7R m6 -CR m9 R m8 -;or,

[0117] R m1 With R m4 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;

[0118] R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl;

[0119] L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0120] Y 10 is a bond, O, NH or N(C 1-4 alkyl);

[0121] R 00 is hydrogen or C 1-6 alkyl;

[0122] Rj 21 For hydrogen, deuterium, halogen, hydroxyl, amino, C 1-6 Alkyl, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Heteroalkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g ;

[0123] Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl, C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Heteroalkyl, -NRjf Rj g or -OC 1-4 Alkylene-NRj f Rj g ;

[0124] Rj f is hydrogen or C 1-6 alkyl;

[0125] Rj g is hydrogen or C 1-6 alkyl;

[0126] Rj 11 and Rj 12 Each is independently hydrogen, halogen or C optionally substituted with one or more (e.g. 1, 2, 3, 4, 5 or 6) S1 1-6 Alkyl; or

[0127] Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1 3-6 cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0128] R 44 、R 45 、R 46 、R 47 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0129] Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08) or R 11 ;

[0130] Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0131] or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by one or more (e.g., 1, 2, 3, 4, 5, or 6) S1, wherein one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0132] Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, heteroaryl, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, heteroaryl are optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0133] R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0134] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl; the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0135] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0136] or R 07 and R 08 Together with the atoms to which it is attached, it forms a 3- to 8-membered heterocyclyl group optionally substituted with one or more (e.g., 1, 2, 3, 4, 5, or 6) S1;

[0137] In the above groups, S1 is independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , SF5, halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Heteroalkyl, C 3- 20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Heteroalkylene-C1-4 Heteroalkylene-C 1-6 Heteroalkylene, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1- 4-alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1- 4-alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by one or more (eg, 1, 2, or 3) groups selected from halogen, deuterium, cyano, hydroxyl, or amino; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by one or more (e.g., 1, 2, 3, or 4) groups selected from Group S2; the nitrogen atom in the 5- or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O- );

[0138] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(O)H, -C(O)-C 1-4 Alkylene-OH, -C(=O)-C 3-6 monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group, -C(=O)-5 to 8-membered heterocyclic group; wherein the C 3-6The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the 5 to 8 membered heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by one or more (e.g., 1 or 2) groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 Alkyl)2, -C(O)C 1-6 Alkyl, -C(O)OC 1-6 Alkyl, -P(=O)-(C 1-6 alkyl)2; or

[0139] Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0140] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0141] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0142] In the above groups, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0143] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 alkyl)2, -(C=O)OC 1-6 Alkyl, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0144] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0145] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0146] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C1-6 alkyl;

[0147] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0148] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0149] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0150] In one embodiment, R m1 is hydrogen, R m2 is hydrogen, R m3 is hydrogen, R m4 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m5 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), and For a single bond.

[0151] In one embodiment, R m1 and R m3 Both do not exist, R m2 is hydrogen, R m4 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1- 6 alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m5 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), and For double bonds.

[0152] In one embodiment, R m1 With R m2 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -, R m3 is hydrogen, R m4 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m5 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl, and For a single bond.

[0153] In one embodiment, R m1 With R m3 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -, R m2 is hydrogen, R m4 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m5 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), and For a single bond.

[0154] In one embodiment, R m1 With R m4 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -, R m2 is hydrogen, R m3 is hydrogen, R m5 is hydrogen, halogen (such as fluorine, chlorine, bromine) or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 Alkyl (e.g. C 1-4 alkyl, such as methyl, ethyl, n-propyl, isopropyl), and For a single bond.

[0155] In one embodiment, the structural unit for R m4 、R m5 As defined in any embodiment.

[0156] In one embodiment, the structural unit for

[0157] In one embodiment, the structural unit for

[0158] In one embodiment, the structural unit for R m4 、R m5 As defined in any embodiment.

[0159] In one embodiment, the structural unit for in, The end is connected to L0, and the * end is connected to other fragments in D.

[0160] In one embodiment, the structural unit for in, The end is connected to L0, and the * end is connected to other fragments in D.

[0161] In one embodiment, The structure represented by formula (II-1), formula (II-2), formula (II-3) or formula (II-4) or a stable deuterated derivative thereof, or a stereoisomer thereof:

[0162] Where,

[0163] X is

[0164] The end is connected to L0, and the * end is connected to other fragments in D;

[0165] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0166] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0167] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0168] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0169] Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or

[0170] Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1;

[0171] L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0172] R 00 is hydrogen or C 1-6 alkyl;

[0173] Rj 21 For hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0174] Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0175] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0176] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0177] R 4a C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1;

[0178] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si;

[0179] R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or

[0180] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0181] R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0182] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si;

[0183] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0184] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0185] Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 )、- P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0186] or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by 1, 2, 3, 4, 5 or 6 Si; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (such as 1, 2 or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus;

[0187] Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0188] R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 of S1;

[0189] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0190] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0191] Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、- C1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0192] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0193] Each R a1 and R b1Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0194] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0195] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0196] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0197] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0198] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0199] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0200] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0201] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0202] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0203] In one embodiment, The structure shown in formula (II-5) or its stable deuterated derivative, or its stereoisomer:

[0204] Where,

[0205] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0206] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0207] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0208] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0209] Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or

[0210] Rj 11and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1;

[0211] L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0212] R 00 is hydrogen or C 1-6 alkyl;

[0213] Rj 21 For hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0214] Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0215] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0216] R 4a C 1-6 Alkyl, C 3-6Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1;

[0217] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si;

[0218] R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or

[0219] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0220] R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j-substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0221] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si;

[0222] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0223] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0224] Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0225] or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by 1, 2, 3, 4, 5 or 6 Si; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (such as 1, 2 or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus;

[0226] Rj4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0227] R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 of S1;

[0228] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0229] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0230] Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1- 4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NRd1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0231] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0232] Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0233] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0234] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0235] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、 =NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0236] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0237] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0238] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0239] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0240] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0241] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0242] In one embodiment, The structure shown in formula (II-6) or its stable deuterated derivative, or its stereoisomer:

[0243] Where,

[0244] X is

[0245] The end is connected to L0, and the * end is connected to other fragments in D;

[0246] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0247] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0248] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0249] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0250] Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or

[0251] Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1;

[0252] L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0253] R 00 is hydrogen or C 1-6 alkyl;

[0254] Rj 21 For hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0255] Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl;

[0256] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0257] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0258] R 4a C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2- 6 alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0259] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05)R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si;

[0260] R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or

[0261] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0262] R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0263] R03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si;

[0264] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0265] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0266] Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0267] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0268] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0269] Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1- 4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -O- C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NRd1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0270] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0271] Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0272] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0273] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0274] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0275] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0276] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0277] In the above groups, R f are independently H, halogen, C 1-6Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0278] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0279] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0280] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above;

[0281] B1 does not exist or is -CH(R9)- or >C=CR9R 9' , optionally substituted 3- to 6-membered cycloalkylene, optionally substituted 3- to 6-membered heterocycloalkylene, optionally substituted 6-membered arylene or 5- to 6-membered heteroarylene;

[0282] L2 does not exist or is a linker;

[0283] W1 is absent or is hydrogen, cyano, optionally substituted amino, optionally substituted C 1-4 Alkoxy, optionally substituted C 1- 4-hydroxyalkyl, optionally substituted C 1-4 aminoalkyl, optionally substituted C 1-4 Haloalkyl, optionally substituted C 1-4 Alkyl, optionally substituted C 1-4 Guanidinoalkyl, optionally C 0-4 alkyl-substituted 3- to 11-membered heterocycloalkyl, optionally substituted 3- to 8-membered cycloalkyl, optionally substituted 6- to 10-membered aryl, or optionally substituted 3- to 8-membered heteroaryl;

[0284] R9 is hydrogen, F, optionally substituted C 1-6 Alkyl, optionally substituted C 1-6 heteroalkyl, optionally substituted 3- to 6-membered cycloalkyl, or optionally substituted 3- to 7-membered heterocycloalkyl; or

[0285] R9 and L2, together with the atoms to which they are attached, form an optionally substituted 3- to 14-membered heterocycloalkyl;

[0286] R 9’ is hydrogen or optionally substituted C 1-6 alkyl.

[0287] In one embodiment, The structure represented by formula (II-6a) or a stable deuterated derivative thereof, or a stereoisomer thereof:

[0288] Where,

[0289] Z1 is C(H), C(deuterium) or N;

[0290] Z2 is C(H), C(deuterium) or N;

[0291] Z3 is C(H), C(deuterium) or N;

[0292] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0293] Y 10 is a bond, O, NH or N(C 1-4 alkyl);

[0294] X is

[0295] The end is connected to L0, and the * end is connected to other fragments in D;

[0296] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0297] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0298] Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or

[0299] Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1;

[0300] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0301] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0302] Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0303] R 4a C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1;

[0304] Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06)(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si;

[0305] R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or

[0306] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0307] R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0308] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si;

[0309] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0310] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0311] Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ;

[0312] Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1;

[0313] R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 of S1;

[0314] R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0315] R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0316] Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1- 4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NRd1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0317] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0318] Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0319] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0320] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1- 6 alkyl)2;

[0321] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0322] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0323] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0324] In the above groups, R f are independently H, halogen, C 1-6Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0325] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0326] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0327] Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

[0328] In one embodiment, Z4, Z5, and Z6 are each independently CR 13 , CR 14 , CR 48 , CR 49 or CR 50 , R 13 、R 14 、R 48 、R49 or R 50 As defined in any embodiment.

[0329] In one embodiment, R 13 and R 14 Each is independently hydrogen, halogen or C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 1-4 In one embodiment, R 13 and R 14 Each is independently hydrogen, fluorine, chlorine, bromine, methyl, ethyl or halomethyl. 13 and R 14 are each independently hydrogen.

[0330] In one embodiment, R 13 and R 14 Together with the connected carbon atoms, it forms C 3-6 cycloalkyl or 3- to 7-membered heterocyclic group.

[0331] In one embodiment, R 48 、R 49 、R 50 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl or C 1-4 In one embodiment, R 48 、R 49 、R 50 are each independently hydrogen, deuterium, fluorine, chlorine, bromine, methyl, ethyl or halomethyl. 48 、R 49 、R 50 are each independently hydrogen.

[0332] In one embodiment, Z4, Z5, and Z6 are each independently CH.

[0333] In one embodiment, R 3a C 1-4 Alkyl or deuterated C 1-4 In one embodiment, R 3a It is methyl or deuterated methyl.

[0334] In one embodiment, Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, S1 being as defined in any embodiment. In one embodiment, Rj 5 For hydrogen, C 1- 6 alkyl, C 1-6 Heteroalkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 1-6 Heteroalkyl or C 3-6 Cycloalkyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, wherein S1 is as defined in any embodiment. In one embodiment, each S1 is independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkyl, NH(C 1-4 alkyl), N(C 1-4 Alkyl) 2, the C 1-4 The alkyl group is optionally substituted with 1, 2 or 3 substituents selected from OH, NH2.

[0335] In one embodiment, Rj 5 For hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHC 1-6 Alkyl or -C 1-4 Alkylene-C 1-6 In one embodiment, Rj 5 For hydrogen, C 1-4 Alkyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHC 1-4 Alkyl or -C 1-4 Alkylene-C 1-4 In one embodiment, Rj 5 is hydrogen or -C 1-4 Alkylene-OH.

[0336] In one embodiment, Rj 5 is ethyl, cyclopropyl, -(CH2)2OH, -(CH2)3OH, -(CH2)2-NH(CH3) or -(CH2)2-OCH3. In one embodiment, Rj 5 is ethyl, -(CH2)2OH, -(CH2)3OH, -(CH2)2-NH(CH3) or -(CH2)2-OCH3. In one embodiment, Rj 5 It is -CH2CH3 or -CH2CH2OCH3.

[0337] In one embodiment, when L0 and Rj 5 When connected, Rj 5 Any hydrogen atom on Rj is replaced by L0, and the Rj 5 As defined in any embodiment.

[0338] In one embodiment, when L0 and Rj 5 When connected, Rj 5 for The end is connected to L0, and the end is connected to the other fragments in D. In one embodiment, when L0 is connected to Rj 5 When connected, Rj 5 for The end is connected to L0, and the * end is connected to other fragments in D.

[0339] In one embodiment, Y1 and Y2 are each independently N, N + -O - , CH or CR 4b , R 4b For deuterium, halogen, C 1-6 Alkyl or C 1-6 In one embodiment, R 4b For deuterium, halogen, C 1-6 Alkyl or C 1-6 In one embodiment, R 4b Halogen, C 1-4 Alkyl or C 1-4 In one embodiment, R 4b is chlorine, methyl or methoxy.

[0340] In one embodiment, Y1 and Y2 are each independently N, N + -O - In one embodiment, Y1 is N or N + -O - In one embodiment, Y2 is CH.

[0341] In one embodiment, when L0 is connected to Y1, any hydrogen atom on Y1 is replaced by L0, or any N atom on Y1 is quaternized, and Y1 is as defined in any embodiment. In one embodiment, when L0 is connected to Y1, Y1 is N + .

[0342] In one embodiment, R 4a for Yj3 is NH-Rj 6 、O-Rj 6 NRj 62 Rj 6 、-C 1-4Alkylene-NH-Rj 6 、-C 1-4 Alkylene-NRj 62 Rj 6 、-C 1-4 Alkylene-O-Rj 6 , where Rj 6 、Rj 62 、Rj 61 As defined in any embodiment, the * end is connected to the other segment in D.

[0343] In one embodiment, Rj 61 C 1-6 In one embodiment, Rj 61 C 1-4 In one embodiment, Rj 61 is methyl, ethyl, n-propyl or isopropyl. In one embodiment, Rj 61 It is a methyl group.

[0344] In one embodiment, Rj 61 For hydrogen.

[0345] In one embodiment, Rj 6 C 1-6 In one embodiment, Rj 6 C 1-4 In one embodiment, Rj 6 is methyl, ethyl, n-propyl or isopropyl. In one embodiment, Rj 6 It is a methyl group.

[0346] In one embodiment, Rj 6 For hydrogen.

[0347] In one embodiment, Rj 62 is hydrogen or C 1-4 In one embodiment, Rj 62 Is hydrogen, methyl, ethyl, n-propyl or isopropyl. In one embodiment, Rj 62 For hydrogen.

[0348] In one embodiment, Yj3 is NH-Rj 6 、O-Rj 6 、-C 1-4 Alkylene-NH-Rj 6 、-C 1-4 Alkylene-O-Rj 6 , where Rj 6 As defined in any embodiment. In one embodiment, Yj3 is NH-Rj 6 or O-Rj 6 , where Rj6 As defined in any embodiment. In one embodiment, Yj3 is NHCH3 or OCH3. In one embodiment, Yj3 is NHCH3. In one embodiment, Yj3 is OCH3.

[0349] In one embodiment, R 4a is C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 1-6 In one embodiment, R 4a For hydroxyl or C 1-4 Heteroalkyl (e.g., methoxy, methylamino) substituted C 1-6 In one embodiment, R 4a -C 1-4 Alkylene-OH, -C 1-4 Alkylene-OC 1-4 Alkyl, -C 1-4 Alkylene-NH-C 1-4 Alkyl or -C 1-4 Alkylene-N(C 1-4 In one embodiment, R 4a It is -CH(CH3)OCH3 or -CH(CH3)NHCH3.

[0350] In one embodiment, when L0 and R 4a When connected, R 4a Any hydrogen atom on the 4a Any nitrogen atom on the 4a As defined in any embodiment. In one embodiment, when L0 and R 4a When connected, R 4a for The end is connected to L0, and the * end is connected to other fragments in D.

[0351] In one embodiment, Yj4 is -C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, 3 to 8-membered monocyclic heterocyclic group, 7 to 12-membered bicyclic heterocyclic group or C 6-10 Aryl, the 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group, C 6-10 Aryl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, R 01 、R 02 are independently hydrogen, C 1-6alkyl or 3 to 8-membered monocyclic heteroalkyl, the C 1-6 The alkyl or 3 to 8 membered monocyclic heteroalkyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, where S1 is as defined in any embodiment.

[0352] In one embodiment, Yj4 is -C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-3 to 8 membered monocyclic heterocyclic group, the 3 to 8 membered monocyclic heterocyclic group is optionally substituted by 1, 2, 3, 4, 5 or 6 S1, R 01 、R 02 are independently hydrogen, C 1-6 alkyl or 3 to 8-membered monocyclic heteroalkyl, the C 1-6 The alkyl or 3 to 8 membered monocyclic heteroalkyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, where S1 is as defined in any embodiment.

[0353] In one embodiment, Yj4 is -sub-C 2-4 Alkynyl-C 1-4 Alkylene-3 to 8 membered monocyclic heterocyclic group or -OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclyl, the 3 to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, where S1 is as defined in any embodiment. In one embodiment, the 3 to 8-membered monocyclic heterocyclyl contains 1, 2 or 3 heteroatoms selected from N, O, and S. In one embodiment, the 3 to 8-membered monocyclic heterocyclyl is azetidinyl, tetrahydropyrrolyl, piperidinyl, piperazinyl, thiomorpholinyl, homomorpholinyl, or homopiperazinyl. In one embodiment, the 3 to 8-membered monocyclic heterocyclyl is piperidinyl, piperazinyl, thiomorpholinyl, homomorpholinyl, or homopiperazinyl. In one embodiment, the 3 to 8-membered monocyclic heterocyclyl is piperidinyl or piperazinyl.

[0354] In one embodiment, S1 is independently hydrogen, hydroxy, cyano, amino, thiol, halogen, carboxyl, nitro, -C 1-6 Alkyl, -C 2-6 Alkenyl, -C 2-6 Alkynyl, -C 1-6 Heteroalkyl, =O, =NH, -(CH2CH2U)pCH3, -C(O)-C 1-4 Alkyl, -C(O)-NH2, -C(O)-NHC 1-6 Alkyl or -C(O)-N(C 1-6 Alkyl) 2, the -C 1-6Alkyl, -C 2-6 Alkenyl, -C 2-6 Alkynyl, -C 1-6 Heteroalkyl is optionally substituted by 1, 2, 3, 4 or 5 groups selected from OH, NH2, CN, SH, halogen, carboxyl, nitro, NH(C 1-6 alkyl), N(C 1-6 alkyl)2, wherein U is independently O or N, and p is 1, 2, 3, 4 or 5.

[0355] In one embodiment, S1 is independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkyl, =O, =NH, -(CH2CH2U)pCH3, -C(O)-C 1-4 Alkyl, -C(O)-NH2, -C(O)-NHC 1-4 Alkyl or -C(O)-N(C 1-4 Alkyl) 2, the C 1-4 The alkyl group is optionally substituted by 1, 2, 3, 4 or 5 groups selected from OH, NH2, NH(C 1-4 alkyl), N(C 1-4 alkyl)2, wherein U is independently O or N, and p is 1, 2, 3, 4 or 5.

[0356] In one embodiment, S1 is independently hydrogen, hydroxyl, cyano, amino, methyl, =O, =NH, -CH2OH, -CH2CH2OCH2CH2NHCH2CH2OCH3, -CH2NH2, -CH(CH3)NH2, -CH2NHCH3, -C(O)CH3, -C(O)CH2OH, -C(O)CH2NH2, -C(O)CH2NH2CH3, -C(O)NHCH2CH2OH.

[0357] In one embodiment, S1 is independently hydroxy, cyano, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH2, =O, =NH, -(CH2CH2U)pCH3, -C(O)-C 1-4 Alkylene-OH or -C(O)-C 1-4 Alkylene-NH2, wherein each U is independently O or N, and p is 1, 2, 3, 4 or 5.

[0358] In one embodiment, S1 is each independently hydroxyl, cyano, =O, =NH, -CH2OH, -CH2CH2OCH2CH2NHCH2CH2OCH3, -CH2NH2, -C(O)CH2OH, -C(O)CH2NH2.

[0359] In one embodiment, each S1 is independently cyano, =O, -CH2CH2OCH2CH2NHCH2CH2OCH3, -CH2NH2, -C(O)CH2OH, -C(O)CH2NH2.

[0360] In one embodiment, Yj4 is 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group or phenyl group, wherein the 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group or phenyl group is optionally substituted by one or more selected from C 1-6 Alkyl, -C 1-4 Alkylene-hydroxy, -C(=O)-C 1-4 Alkylene-hydroxy or -C 1-4 Substitutents of alkylene-3 to 8-membered monocyclic heterocyclic group,

[0361] Rj 7 or Rj 13 Each independently NR 01 R 02 , 4- to 5-membered monocyclic heterocyclic group, oxo 5-membered heterocyclic group -Lj1-Lj2-Rj 14 , 6-membered heterocyclic group-Lj1-Lj2-Rj 14 or oxo 7-membered heterocyclic group-Lj1-Lj2-Rj 14 , the 4 to 5 membered monocyclic heterocyclic group is optionally substituted by hydroxyl, cyano or amino, the Rj 7 Optionally -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-Rj 6 replace,

[0362] Rj 71 For hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-Rj 6 ,

[0363] Rj 8 is O or NH,

[0364] Xj1 is -O-, -CRj 91 Rj 92 -or-NRj 10 -,

[0365] mj is 1 or 2,

[0366] Lj1 and Lj2 are each independently -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-,

[0367] Rj 14 C 1-6 heteroalkyl,

[0368] Rj 6 is hydrogen or C 1-6 alkyl,

[0369] Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -NRj c Rj d 、-C 1-4 Alkylene-NRj c Rj d 、-C 1-4 Alkylene-OH, -C(O)-NRj a Rj b or -C(O)-NRj c Rj d , the -C 1-4 Alkylene - optionally substituted with methyl;

[0370] Rj 10 For hydrogen, C 1-6 Alkyl, -C(O)-C 1-6 Alkyl, -C(O)-C 1-4 Alkylene-NRj f Rj g or -C(O)-C 1-4 Alkylene-OH;

[0371] Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl,

[0372] Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-6 Alkyl, -C 1-4 Alkylene-OH, 5- to 8-membered heterocyclic group, -C(O)-5- to 8-membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from Rj 42 Substituents substituted,

[0373] Rj 42 Methyl, -NRj f Rj g 、-C(O)Rj e or -C(O)ORj e ,

[0374] Rj e C 1-6 alkyl,

[0375] Rj f 、Rj g are each independently hydrogen or C 1-6 alkyl.

[0376] In one embodiment, Yj4 is Rj 7 、Rj 71 、Rj 13 As defined in any embodiment.

[0377] In one embodiment, Rj 71 For hydrogen, C 1-4 Alkyl, -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH2. In one embodiment, Rj 71 Is hydrogen, methyl, ethyl, -CH2OH or -CH2NH2. In one embodiment, Rj 71 Is hydrogen, -CH2OH or -CH2NH2. In one embodiment, Rj 71 For hydrogen.

[0378] In one embodiment, Rj 71 -C 1-4 In one embodiment, Rj 71 In one embodiment, Rj 71 For hydrogen, C 1-6 Alkyl or -C 1-4 Alkylene-OH.

[0379] In one embodiment, Rj 7 or Rj 13 Each independently NR 01 R 02 or oxo 6-membered heterocyclic group-Lj1-Lj2-Rj 14 , the Rj 7 Optionally -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-Rj 6 Replace, Rj 8 、Xj1、mj、R 01 、R 02 、Lj1、Lj2、Rj 14 As defined in any embodiment, the * end is connected to the other segment in D.

[0380] In one embodiment, Rj 7 for NR 01 R 02 , the Rj 7 Optionally -C 1-4 Alkylene-OH substitution, Rj 8 、Xj1、mj、R 01 、R 02 As defined in any embodiment, the * end is connected to the other segment in D. In one embodiment, Rj 7 for Rj 8 , Xj1, mj are as defined in any embodiment.

[0381] In one embodiment, Xj1 is -CRj 91 Rj 92 -or-NRj 10 -, Rj 91 、Rj 92 、Rj 10 As defined in any embodiment, the * end is connected to the other segment in D.

[0382] In one embodiment, Rj 7 for Xj1 is -CRj 91 Rj 92 -or-NRj 10 -, Rj 91 、Rj 92 、Rj 10 , mj are as defined in any embodiment, and the * end is connected to the other fragment in D.

[0383] In one embodiment, R 01 、R 02 are independently hydrogen, C 1-4 In one embodiment, R 01 、R 02 Each is independently hydrogen, methyl, ethyl, n-propyl, isopropyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl. In one embodiment, R 01 、R 02 Each is independently methyl, isopropyl or tetrahydropyranyl.

[0384] In one embodiment, R 01 It is a methyl group.

[0385] In one embodiment, R 02 is isopropyl or tetrahydropyranyl.

[0386] In one embodiment, Rj 6 is hydrogen or C 1-4 In one embodiment, Rj 6 Is hydrogen, methyl, ethyl, n-propyl or isopropyl. In one embodiment, Rj 6 For hydrogen.

[0387] In one embodiment, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -NRj c Rj d 、-C 1-4 Alkylene-NRj c Rj d 、-C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in any embodiment. In one embodiment, Rj 91 、Rj 92 are independently hydrogen, hydroxy, cyano, -C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in any embodiment.

[0388] In one embodiment, Rj 91 、Rj 92 Each is independently hydrogen, hydroxyl, cyano, amino, -NHC 1-4 Alkyl, -N(C 1-4 Alkyl)2, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NHC 1-4 Alkyl, -C 1-4 Alkylene-N(C 1-4 Alkyl)2, -C(O)-NH2, -C(O)-NHC 1-4 Alkyl, -C(O)-NHC 1-4 Alkylene-OH or -C(O)-N(C 1-4 In one embodiment, Rj 91 、Rj 92 are independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH2, -C1-4 Alkylene-NHC 1-4 Alkyl or -C(O)-NHC 1-4 In one embodiment, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, amino, -CH2OH, -CH2NH2, -CH(CH3)NH2, -CH2NHCH3 or -C(O)NHCH2CH2OH.

[0389] In one embodiment, Rj 91 、Rj 92 are independently hydrogen, hydroxy, cyano, -C(O)-C 1-4 Alkyl, -C(O)-C 1-4 Alkylene-NH2. In one embodiment, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -CH2OH, or -CH2NH2.

[0390] In one embodiment, Rj 91 Is hydrogen, hydroxy or cyano. In one embodiment, Rj 91 It is a cyano group.

[0391] In one embodiment, Rj 92 It is hydrogen, amino, -CH2OH, -CH2NH2 or -C(O)NHCH2CH2OH.

[0392] In one embodiment, Rj 91 、Rj 92 Not hydrogen at the same time.

[0393] In one embodiment, Rj 10 For hydrogen, C 1-4 Alkyl, -C(O)-C 1-4 Alkyl, -C(O)-C 1-4 Alkylene-NH2, -C(O)-C 1- 4-Alkylene-NHC 1-4 Alkyl, -C(O)-C 1-4 Alkylene-N(C 1-4 alkyl)2 or -C(O)-C 1-4 Alkylene-OH.

[0394] In one embodiment, Rj 10In one embodiment, Rj is hydrogen, methyl, ethyl, n-propyl, isopropyl, -C(O)CH3, -C(O)CH2CH3, -C(O)CH(CH3)2, -C(O)CH2NH2, -C(O)CH2CH2NH2, -C(O)CH2NHCH3, -C(O)CH2N(CH3)2, -C(O)CH2CH2NHCH3, -C(O)CH2OH or -C(O)CH2CH2OH. 10 is hydrogen, methyl, -C(O)CH3, -C(O)CH2OH or -C(O)CH2NH2.

[0395] In one embodiment, Rj 10 is hydrogen, -C(O)-C 1-4 Alkylene-NH2 or -C(O)-C 1-4 In one embodiment, Rj 10 Is hydrogen, -C(O)CH2OH or -C(O)CH2NH2. In one embodiment, Rj 10 It is -C(O)CH2OH or -C(O)CH2NH2.

[0396] In one embodiment, Rj a 、Rj b are each independently hydrogen or C 1-4 In one embodiment, Rj a 、Rj b Each is independently hydrogen, methyl, ethyl, n-propyl or isopropyl. In one embodiment, R a 、Rj b are each independently hydrogen.

[0397] In one embodiment, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from Rj 42 Substituents substituted, said Rj 42 As defined in any embodiment.

[0398] In one embodiment, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-4 Alkyl, -C 1-4 Alkylene-OH or -C(O)- C 1-4 Alkylene-OH.

[0399] In one embodiment, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene-OH or -C(O)-C 1-4 In one embodiment, Rj c 、Rj d are independently hydrogen, C 1-4 Alkyl, -C 1-4 Alkylene-OH or -C(O)-C 1-4 In one embodiment, Rj c 、Rj d Each is independently hydrogen, methyl, ethyl, n-propyl, isopropyl, -C(O)CH3, -C(O)CH2CH3, -C(O)CH(CH3)2, -C(O)CH2OH or -C(O)CH2CH2OH.

[0400] In one embodiment, Rj 42 Methyl, -NRj f Rj g 、-C(O)Rj e or -C(O)ORj e , Rj f 、Rj g 、Rj e As defined in any embodiment. In one embodiment, Rj 42 is methyl, -C(O)Rj e or -C(O)ORj e , Rj e As defined in any embodiment.

[0401] In one embodiment, Rj e C 1-4 In one embodiment, Rj e is methyl, ethyl, n-propyl or isopropyl. In one embodiment, Rj e It is a methyl group.

[0402] In one embodiment, Rj f 、Rj g are each independently hydrogen or C 1-4 In one embodiment, Rj f 、Rj g Each is independently hydrogen, methyl, ethyl, n-propyl or isopropyl. In one embodiment, R f 、Rj g are each independently hydrogen or methyl.

[0403] In one embodiment, Rj 7 for Rj 91 、Rj 92 are each independently hydrogen, hydroxy, cyano, -NH2, -CH2NH2, -CH2NH(CH3), -CH2OH or -C(O)-NH(CH2CH2OH), Rj 91 、Rj 92 are not hydrogen at the same time, mj is 1 or 2, and the * end is connected to the other fragments in D. In one embodiment, Rj 91 It is a cyano group.

[0404] In one embodiment, Rj 7 for Rj 10 It is hydrogen or -C(O)CH2OH, mj is 1 or 2, and the * end is connected to other fragments in D.

[0405] In one embodiment, Rj 7 for The * end is connected to the other fragment in D.

[0406] In one embodiment, Rj 7 for In one embodiment, Rj 7 for The * end is connected to the other fragment in D.

[0407] In one embodiment, Rj 7 for In one embodiment, Rj 7 for The * end is connected to the other fragment in D.

[0408] In one embodiment, Rj 7 for In one embodiment, Rj 7 for The * end is connected to the other fragment in D.

[0409] In one embodiment, Rj 7 for The * end is connected to the other fragment in D.

[0410] In one embodiment, Rj 13 for Oxo 6-membered heterocyclic group-Lj1-Lj2-Rj 14 , Rj 8 、Xj1、mj、Lj1、Lj2、Rj 14 As defined in any embodiment, the * end is connected to the other segment in D.

[0411] In one embodiment, Xj1 is -CRj 91 Rj 92 -, Rj 91 、Rj 92 As defined in any embodiment.

[0412] In one embodiment, Rj 91 、Rj 92 are independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NHC 1-4 Alkyl, -C 1-4 Alkylene-N(C 1-4 alkyl)2, and Rj 91 、Rj 92 Not hydrogen at the same time.

[0413] In one embodiment, Rj 91 is cyano, Rj 92 It is -CH2NH2.

[0414] In one embodiment, mj is 1.

[0415] In one embodiment, Lj1 is -C 1-4 Alkylene-O-. In one embodiment, Lj1 is -CH2-O-, -CH2CH2-O-, or -CH2(CH2)2-O-. In one embodiment, Lj1 is -CH2CH2-O-.

[0416] In one embodiment, Lj2 is -C 1-4 Alkylene-NH-. In one embodiment, Lj2 is -CH2-NH-, -CH2CH2-NH- or -CH2(CH2)2-NH-. In one embodiment, Lj2 is -CH2CH2-NH-.

[0417] In one embodiment, Rj 14 C 1-4 In one embodiment, Rj 14In one embodiment, Rj is -CH2OCH3, -CH2CH2OCH3, -CH2NHCH3, -CH2N(CH3)2, -CH2CH2NHCH3 or -CH2CH2N(CH3)2. 14 In one embodiment, Rj 14 It is -CH2CH2OCH3.

[0418] In one embodiment, Rj 13 for The * end is connected to the other fragment in D.

[0419] In one embodiment, Rj 13 for Oxo 6-membered heterocyclic group-Lj1-Lj2-Rj 14 , Rj 8 、Lj1、Lj2、Rj 14 As defined in any embodiment, the * end is connected to the other segment in D. In one embodiment, Rj 13 for In one embodiment, Rj 13 for The * end is connected to the other fragment in D.

[0420] In one embodiment, Rj 13 is an oxo 6-membered heterocyclic group -Lj1-Lj2-Rj 14 , Rj 8 、Lj1、Lj2、Rj 14 As defined in any embodiment. In one embodiment, Rj 13 for The * end is connected to the other fragment in D.

[0421] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0422] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0423] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0424] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0425] In one embodiment, Yj4 is a 5- to 7-membered nitrogen-containing monocyclic heterocyclic group, a 9- to 10-membered nitrogen-containing bicyclic heterocyclic group, or a phenyl group, wherein the 5- to 7-membered nitrogen-containing monocyclic heterocyclic group, the 9- to 10-membered nitrogen-containing bicyclic heterocyclic group, or the phenyl group is optionally substituted by one or more selected from C 1-4 Alkyl, -methylene-hydroxy, -C(=O)C 1-4 The substituents are substituted by -OH or -methylene-5 to 7-membered nitrogen-containing monocyclic heterocyclic groups.

[0426] In one embodiment, Yj4 is piperidinyl, piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclyl or phenyl, and the piperidinyl, piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclyl or phenyl is optionally substituted with one or more substituents selected from methyl, -methylene-hydroxy, -methylene-morpholinyl, -C(=O)CH2OH or -methylene-piperazinyl.

[0427] In one embodiment, Yj4 is In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0428] In one embodiment, Yj4 is piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclyl, and the piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclyl is optionally substituted with one or more substituents selected from methyl, C(=O)CH2OH.

[0429] In one embodiment, Yj4 is In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0430] In one embodiment, when L0 is linked to Yj4, any hydrogen atom on Yj4 is replaced by L0, or any N atom on Yj4 is quaternized, and Yj4 is as defined in any embodiment.

[0431] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0432] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0433] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the end is connected to other fragments in D. In one embodiment, when L0 is connected to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0434] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0435] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0436] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0437] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0438] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment.

[0439] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0440] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0441] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0442] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0443] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0444] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0445] In one embodiment, the structural unit for X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0446] In one embodiment, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0447] In one embodiment, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0448] In one embodiment, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0449] In one embodiment, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0450] In one embodiment, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any embodiment, The end is connected to L0, and the * end is connected to other fragments in D.

[0451] In one embodiment, Lj is -NHC(=O)-, -N(C 1-6 alkyl)C(=O)-, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, the C 6-10Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 instances of S1, wherein S1 is as defined in any embodiment.

[0452] In one embodiment, S1 is independently selected from deuterium, oxo (=O), thio (=S), halogen, cyano, hydroxy, carboxyl, nitro, amino, C 1-6 In one embodiment, S1 is independently selected from deuterium, halogen, cyano, hydroxyl, amino, C 1- 4 alkyl groups.

[0453] In one embodiment, Lj is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 Aryl is optionally substituted with hydroxy or amino. In one embodiment, Lj is phenyl, thiazolyl, oxazolyl, 1,3,4-oxadiazolyl or 1,2,4-oxadiazolyl, and the phenyl is optionally substituted with hydroxy or amino. In one embodiment, Lj is phenyl, oxazolyl or thiazolyl, and the phenyl is optionally substituted with hydroxy or amino.

[0454] In one embodiment, Lj is phenyl, * end is connected to the other fragments in D. In one embodiment, Lj is * end is connected to the other fragments in D. In one embodiment, Lj is The * end is connected to the other fragment in D.

[0455] In one embodiment, Lj is oxazolyl or thiazolyl. In one embodiment, Lj is The * end is connected to the other fragment in D.

[0456] In one embodiment, Lj is thiazolyl. In one embodiment, Lj is The * end is connected to the other fragment in D.

[0457] In one embodiment, Y 10 is O, NH, NCH3, NCH2CH3 or NCH(CH3)2. In one embodiment, Y 10 is O or NH.

[0458] In one embodiment, when L0 is linked to Lj, any hydrogen atom on Lj is replaced by L0, or any N atom on Lj is quaternized, and Lj is as defined in any embodiment.

[0459] In one embodiment, when L0 is linked to Lj, Lj is Further Lj is The end is connected to L0, and the * end is connected to other fragments in D.

[0460] In one embodiment, Rj 21 、Rj 22 are independently hydrogen, C 1-6 Alkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g , Rj f 、Rj g As defined in any embodiment. In one embodiment, Rj 21 、Rj 22 are independently hydrogen, C 1-4 Alkyl, -NRj f Rj g 、-OC 1-4 Alkylene-NRj f Rj g , Rj f 、Rj g As defined in any embodiment.

[0461] In one embodiment, Rj f 、Rj g are each independently hydrogen or C 1-4 In one embodiment, Rj f 、Rj g Each is independently hydrogen, methyl, ethyl, n-propyl or isopropyl.

[0462] In one embodiment, Rj 21 、Rj 22 Each independently represents hydrogen, amino, -NH(C 1-4 Alkyl), -N(C 1-4 Alkyl)2, -OC 1- 4-alkylene-NH(C 1-4 alkyl) or -OC 1-4 Alkylene-N(C 1-4 Alkyl)2.

[0463] In one embodiment, Rj 21 is hydrogen, amino, -NH(CH3), -OCH2CH2NHCH3 or -OCH2CH2N(CH3)2. In one embodiment, Rj 21 In one embodiment, Rj 22 For hydrogen.

[0464] In one embodiment, when L0 and Rj 21 When connected, Rj21 Any hydrogen atom on the 21 Any nitrogen atom on the 21 As defined in any embodiment.

[0465] In one embodiment, when L0 and Rj 21 When connected, Rj 21 -NH-, -N(CH3)-, in, The end is connected to L0, and the * end is connected to other fragments in D.

[0466] In one embodiment, when L0 and Rj 21 When connected, Rj 21 -NH-, -N(CH3)-, in, The end is connected to L0, and the * end is connected to other fragments in D.

[0467] In one embodiment, Rj 11 、Rj 12 are independently hydrogen, deuterated C 1-6 Alkyl or C 1-6 In one embodiment, Rj 11 and Rj 12 are independently hydrogen, deuterated C 1-4 Alkyl or C 1-4 In one embodiment, Rj 11 and Rj 12 Each independently is methyl or deuterated methyl. In one embodiment, R 11 and Rj 12 It is a methyl group.

[0468] In one embodiment, Rj 11 and Rj 12 Together with the connected carbon atoms, it forms C 3-6 Cycloalkyl or 3 to 7 membered heterocyclyl. In one embodiment, Rj 11 and Rj 12 Together with the carbon atom to which it is attached, R forms a cyclopropyl, cyclobutyl, azetidinyl or oxetanyl group. In one embodiment, R 11 and Rj 12 Together with the attached carbon atom, it forms a cyclopropyl group.

[0469] In one embodiment, R 44 、R 45 、R 46 、R 47 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl or C1-4 In one embodiment, R 44 、R 45 、R 46 、R 47 are each independently hydrogen, deuterium, fluorine, chlorine, bromine, methyl, ethyl or halomethyl. 44 、R 45 、R 46 、R 47 For hydrogen.

[0470] In one embodiment, Y3 is -C(=O)Rj 4 or R 11 ,

[0471] Rj 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more Rj 41 replace,

[0472] R 11 is a 5- or 6-membered monocyclic heteroaryl or an 8- to 10-membered bicyclic heteroaryl, wherein the 5- or 6-membered monocyclic heteroaryl or the 8- to 10-membered bicyclic heteroaryl is optionally substituted by one or more Rj 41 replace,

[0473] Rj 41 C 1-6 Alkyl, hydroxyl, SF5, NRj c Rj d 、-P(=O)(C 1-6 Alkyl)2, -C 1-4 Alkylene-OH or -C(O)-NRj c Rj d ,

[0474] Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl,

[0475] Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, phenyl, 5- or 6-membered monocyclic heteroaryl, -C1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, wherein the 5 to 8 membered heterocyclic group is optionally replaced by one or more Rj 42 replace,

[0476] Rj 42 C 1-6 Alkyl, halogenated C 1-6 Alkyl, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C(O)C 1-6 Alkyl or -C(O)OC 1-6 alkyl.

[0477] In one embodiment, Y3 is -C(=O)Rj 4 , Rj 4 As defined in any embodiment.

[0478] In one embodiment, Rj 4 C 6-10 Aryl, 5 or 6 membered monocyclic heteroaryl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 6-10 Aryl, 5 or 6 membered monocyclic heteroaryl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more Rj 41 Substitution, the Rj a 、Rj b 、Rj c 、Rj d 、Rj 41 As defined in any embodiment.

[0479] In one embodiment, Rj 4 C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more Rj 41 Substituents substituted, said Rj a 、Rj b 、Rj c 、Rj d 、Rj 41 As defined in any embodiment.

[0480] In one embodiment, Rj 4 C 3-6 Cycloalkyl, 5- to 8-membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 3-6 The cycloalkyl group is optionally substituted with one or more Rj 41 Substitution, the Rj a 、Rj b 、Rj c 、Rj d 、Rj 41 As defined in any embodiment.

[0481] In one embodiment, Rj 4 is cyclopropyl, cyclobutyl, cyclopentyl, 5- to 8-membered bicyclic heterocyclic group or -CHRj b -NRj c Rj d The cyclopropyl, cyclobutyl, cyclopentyl, 5 to 8 membered bicyclic heterocyclic group is optionally substituted by 1, 2, 3, 4 or 5 Rj 41 Substitution, the Rj b 、Rj c 、Rj d 、Rj 41 As defined in any embodiment.

[0482] In one embodiment, Rj 4 It is a 5- to 8-membered oxa-heterocyclic group, and preferably a 5- to 8-membered oxa-fused heterocyclic group.

[0483] In one embodiment, Rj 4 C 3-6 Cycloalkyl, the C 3-6 The cycloalkyl group is optionally substituted with 1, 2, 3, 4 or 5 Rj 41 Replace, Rj 41 As defined in any embodiment.

[0484] In one embodiment, Rj 41 For hydroxyl, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 In one embodiment, Rj 41 It is hydroxy, methyl, -CH2OH or -C(O)-NH(CH2CH2OH).

[0485] In one embodiment, Rj 4 -CRj a Rj b -NRj cRj d , Rj a 、Rj b 、Rj c 、Rj d As defined in any embodiment. In one embodiment, Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl or -C(O)-C 1-4 Alkylene-OH.

[0486] In one embodiment, Rj 4 -CRj a Rj b -NRj c Rj d , Rj a 、Rj b are each independently hydrogen or C 1-6 Alkyl, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl or -C(O)-tetrahydropyrrole, wherein the tetrahydropyrrole is optionally substituted with 1, 2, 3, 4 or 5 Rj 42 Replace, Rj 42 It is methyl or -C(O)OCH3.

[0487] In one embodiment, Rj 41 C 1-4 Alkyl, hydroxyl, NRj c Rj d 、-C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in any embodiment. In one embodiment, Rj 41 is methyl, ethyl, hydroxy, amino, CH2OH, CH2CH2OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in any embodiment. In one embodiment, Rj 41 It is methyl, hydroxy, CH2OH or -C(O)NHCH2CH2OH.

[0488] In one embodiment, Rj41 C 1-4 Alkyl, hydroxyl, -C 1-4 In one embodiment, Rj 41 It is methyl, hydroxyl, CH2OH.

[0489] In one embodiment, Rj 41 C 1-4 In one embodiment, Rj 41 It is a methyl group.

[0490] In one embodiment, Rj 41 It is an amino group.

[0491] In one embodiment, Rj 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in any embodiment.

[0492] In one embodiment, Rj a 、Rj b are independently hydrogen, C 1-4 Alkyl or C 3-5 In one embodiment, Rj a 、Rj b Each is independently hydrogen, methyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclobutyl or cyclopentyl. In one embodiment, R a 、Rj b Each is independently hydrogen, isopropyl, cyclobutyl or cyclopentyl.

[0493] In one embodiment, Rj a For hydrogen.

[0494] In one embodiment, Rj b is isopropyl, cyclobutyl or cyclopentyl.

[0495] In one embodiment, Rj b C 1-4 In one embodiment, Rj b For isopropyl and cyclobutyl.

[0496] In one embodiment, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-4 Alkyl, C 1-4 Halogenated alkyl, phenyl, pyridyl, -C 1-4Alkylene-OH, -C(O)-5 to 6 membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 6 membered heterocyclic group is optionally replaced by one or more Rj 42 Substitution, the Rj 42 As defined in any embodiment.

[0497] In one embodiment, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-4 Alkyl, C 1-4 Haloalkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 6 membered monocyclic heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 6 membered monocyclic heterocyclic group is optionally substituted by one or more Rj 42 Substitution, the Rj 42 As defined in any embodiment.

[0498] In one embodiment, Rj c 、Rj d Each is independently hydrogen, methyl, ethyl, fluoromethyl, fluoroethyl, -C(O)H, -C(=O)CH2OH, -C(=O)CH2CH2OH, -C(=O)-azetidinyl or -C(=O)-pyrrolidinyl, wherein the azetidinyl or pyrrolidinyl group is optionally substituted by 1, 2 or 3 Rj 42 Substitution, the Rj 42 As defined in any embodiment. In one embodiment, Rj c 、Rj d Each is independently hydrogen, methyl, -C(=O)CH2OH, -C(=O)CH2CH2OH, -C(=O)-azetidinyl-NHCH3 or -C(=O)-pyrrolidinyl(methyl)-C(=O)OCH3.

[0499] In one embodiment, Rj c 、Rj d are each independently hydrogen or C 1-4 In one embodiment, Rj c 、Rj d are each independently hydrogen or methyl.

[0500] In one embodiment, Rj 42 C 1-4 Alkyl, halogenated C 1-4 Alkyl, -NHC 1-4 Alkyl, -N(C 1-4 Alkyl)2, -C(O)C 1- 4-alkyl or -C(O)OC1-4 In one embodiment, Rj 42 is methyl, ethyl, halomethyl, haloethyl, -NHCH3, -N(CH3)2, -C(O)CH3 or -C(O)OCH3. In one embodiment, Rj 42 It is methyl, -NHCH3 or -C(O)OCH3.

[0501] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0502] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0503] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0504] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0505] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0506] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0507] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0508] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0509] In one embodiment, R 11 is an 8- to 10-membered bicyclic heteroaryl group, the 8- to 10-membered bicyclic heteroaryl group is optionally substituted by one or more Rj 41 Substitution, the Rj 41 As defined in any embodiment.

[0510] In one embodiment, R11 is an 8- to 10-membered bicyclic heteroaryl group containing one or more nitrogen heteroatoms, and the 8- to 10-membered bicyclic heteroaryl group is optionally substituted by one or more Rj 41 Substitution, the Rj 41 As defined in any embodiment.

[0511] In one embodiment, R 11 is indolyl, quinolyl or triazolopyridinyl, said indolyl, quinolyl or triazolopyridinyl being optionally substituted by 1, 2, 3, 4 or 5 Rj 41 Substitution, the Rj 41 As defined in any embodiment.

[0512] In one embodiment, R 11 for The * end is connected to the other fragment in D.

[0513] In one embodiment, Y3 is The * end is connected to the other fragment in D.

[0514] In one embodiment, when L0 is linked to Y3, any hydrogen atom on Y3 is replaced by L0, or any N atom on Y3 is quaternized, and Y3 is as defined in any embodiment.

[0515] In one embodiment, when L0 is linked to Y3, Y3 is in, The end is connected to L0, and the * end is connected to other fragments in D.

[0516] In one embodiment, when L0 is linked to Y3, Y3 is in, The end is connected to L0, and the * end is connected to other fragments in D.

[0517] In one embodiment, when L0 is linked to Y3, Y3 is in, The end is connected to L0, and the * end is connected to other fragments in D.

[0518] In one embodiment, when L0 and Rj 4 When connected, Rj 4 Any hydrogen atom on the 4 Any nitrogen atom on the 4 As defined in any embodiment.

[0519] In one embodiment, when L0 and Rj 4 When connected, Rj 4 for in, The end is connected to L0, and the * end is connected to other fragments in D.

[0520] In one embodiment, when L0 and Rj 4 When connected, Rj 4 for in, The end is connected to L0, and the * end is connected to other fragments in D.

[0521] In one embodiment, when L0 and Rj 4 When connected, Rj 4 for in, The end is connected to L0, and the * end is connected to other fragments in D.

[0522] In one embodiment, Rj 3 is hydrogen or C 1-6 In one embodiment, Rj 3 is hydrogen or C 1-4 In one embodiment, Rj 3 Is hydrogen, methyl or ethyl. In one embodiment, Rj 3 Is hydrogen or methyl. In one embodiment, Rj 3 For hydrogen.

[0523] In one embodiment, -D is a structure represented by formula (II-1), formula (II-2), formula (II-3) or formula (II-4) or a stereoisomer thereof:

[0524] Where,

[0525] X is

[0526] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0527] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0528] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0529] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0530] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0531] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0532] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0533] R 00 is hydrogen or C 1-6 alkyl;

[0534] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0535] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0536] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0537] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0538] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0539] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、 -CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 );

[0540] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0541] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0542] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0543] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0544] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0545] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0546] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0547] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0548] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0549] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0550] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0551] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0552] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20 membered heterocyclic group, -C≡CC6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3- 20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1- 4-alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1- 4-alkylene-C 6-14 Aryl, -OC1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1- 6-alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0553] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0554] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0555] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0556] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1- 4-alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0557] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0558] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0559] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0560] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0561] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0562] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0563] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0564] In one embodiment, -D is a structure as shown in formula (II-5) or a stereoisomer thereof:

[0565] Where,

[0566] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0567] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0568] R 44 、R 45 、R 46 、R 47are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0569] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0570] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0571] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0572] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0573] R 00 is hydrogen or C 1-6 alkyl;

[0574] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0575] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0576] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0577] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0578] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06)(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、- S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 );

[0579] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0580] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0581] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0582] R 03 、R 04Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0583] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0584] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0585] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0586] or Y3, R 12 Together with the nitrogen atom to which they are attached, they form a substituted or unsubstituted nitrogen-containing 3- to 8-membered heterocyclic group; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more (e.g., 1, 2, or 3) ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0587] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0588] R11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0589] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0590] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0591] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3- 20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1- 4-alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1- 4-alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1- 6-alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0592] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0593] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0594] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0595] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1- 4-alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0596] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0597] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0598] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0599] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0600] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0601] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0602] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0603] In one embodiment, -D is a structure as shown in formula (II-6) or a stereoisomer thereof:

[0604] Where,

[0605] X is

[0606] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0607] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0608] R 44 、R45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0609] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0610] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0611] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0612] L1 is -N(R 00 )C(=O)-, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0613] R 00 is hydrogen or C 1-6 alkyl;

[0614] R1 is hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0615] R2 is hydrogen, deuterium, halogen, C 1-6 Alkyl or substituted or unsubstituted C 1-6 heteroalkyl;

[0616] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0617] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0618] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0619] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 );

[0620] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0621] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0622] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0623] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0624] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0625] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0626] R 12 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0627] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0628] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0629] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0630] R08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0631] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1- 4-alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1- 4-alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 Rb1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1- 6-alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-Rc1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0632] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0633] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0634] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0635] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1- 4-alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0636] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0637] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-41, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0638] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0639] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0640] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0641] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0642] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above;

[0643] B1 does not exist or is -CH(R9)- or >C=CR9R 9’ , optionally substituted 3- to 6-membered cycloalkylene, optionally substituted 3- to 6-membered heterocycloalkylene, optionally substituted 6-membered arylene or 5- to 6-membered heteroarylene;

[0644] L2 does not exist or is a linker;

[0645] W1 is absent or is hydrogen, cyano, optionally substituted amino, optionally substituted C 1-4 Alkoxy, optionally substituted C 1-4 Hydroxyalkyl, optionally substituted C 1-4 aminoalkyl, optionally substituted C 1-4 Haloalkyl, optionally substituted C 1-4 Alkyl, optionally substituted C1-4 Guanidinoalkyl, optionally C 0-4 alkyl-substituted 3- to 11-membered heterocycloalkyl, optionally substituted 3- to 8-membered cycloalkyl, optionally substituted 6- to 10-membered aryl, or optionally substituted 3- to 8-membered heteroaryl;

[0646] R9 is hydrogen, F, optionally substituted C 1-6 Alkyl, optionally substituted C 1-6 heteroalkyl, optionally substituted 3- to 6-membered cycloalkyl, or optionally substituted 3- to 7-membered heterocycloalkyl; or

[0647] R9 and L2, together with the atoms to which they are attached, form an optionally substituted 3- to 14-membered heterocycloalkyl;

[0648] R 9’ is hydrogen or optionally substituted C 1-6 alkyl.

[0649] In one embodiment, -D is a structure as shown in formula (II-6a) or a stereoisomer thereof:

[0650] Where,

[0651] Z1 is C(H), C(deuterium) or N;

[0652] Z2 is C(H), C(deuterium) or N;

[0653] Z3 is C(H), C(deuterium) or N;

[0654] Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy;

[0655] Y 10 H, O or NR 20 ; R 20 H or C 1-4 alkyl;

[0656] X is

[0657] Y1 is N or CH; wherein N can be oxidized (N + -O - );

[0658] Y2 is N or CH; wherein N can be oxidized (N + -O - );

[0659] R 42 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 Alkyl; or

[0660] R 42 and R 43 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0661] R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Halogenated alkyl, C 1-4 alkoxy;

[0662] R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0663] R3 is hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0664] R 4a is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 a cycloalkyl group or a substituted or unsubstituted 3- to 8-membered heterocyclic group;

[0665] R5 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-substituted or unsubstituted 3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -OC 1-4 Alkylene-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -O-substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group, -O-substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, -O-substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04);

[0666] R 01 、R 02 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted 3 to 6 membered cycloalkyl, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; or,

[0667] R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclic group, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclic group, or a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group;

[0668] R 03 、R 04 are each independently selected from hydrogen, substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Alkoxy, substituted or unsubstituted C 2-6 Alkenyl, substituted or unsubstituted C 2-6 Alkynyl; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or

[0669] R 03 、R 04 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl, a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0670] R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl;

[0671] R 06 is hydrogen, deuterium or C 1-6 alkyl;

[0672] Y3 is -C(=O)R6, -C(=S)R6, -S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NR6-S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ;

[0673] R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 1-6 Heteroalkyl, substituted or unsubstituted C 3-6 Cycloalkyl, substituted or unsubstituted 3 to 8 membered heterocyclic group, substituted or unsubstituted C 6-10 aryl, substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, or substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl;

[0674] R 11 is a substituted or unsubstituted 3- to 10-membered heterocyclyl, a substituted or unsubstituted 5- or 6-membered monocyclic heteroaryl, a substituted or unsubstituted 8- to 10-membered bicyclic heteroaryl, a substituted or unsubstituted 6- to 12-membered heteroarylcycloalkyl, a substituted or unsubstituted 6- to 12-membered heteroarylheterocyclyl, a substituted or unsubstituted 7- to 12-membered bicyclic heterocyclyl, or a substituted or unsubstituted 5- to 15-membered tricyclic heterocyclyl;

[0675] R 07 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0676] R 08 is hydrogen, deuterium, substituted or unsubstituted C 1-6 Alkyl or substituted or unsubstituted C 3-6 Cycloalkyl; the substitution refers to substitution by one or more (eg, 1, 2, 3, or 4) groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl;

[0677] In each of the above groups, the substitution independently refers to the above groups being independently substituted by 1, 2, 3, 4, 5 or 6 groups selected from Group S1; the groups of Group S1 are independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3- 20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1- 4-alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1- 4-alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkyl-C 3-20 Cycloalkyl, -C(=O)-C 1- 6-alkyl-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkyl-C 6-14 Aryl, -C(=O)-C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkyl-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NRa1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2;

[0678] In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or

[0679] Each R a1 and R b1 Together with the nitrogen atom to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0680] In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0681] In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1- 4-alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1- 4-alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2;

[0682] In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5;

[0683] In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j-substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace;

[0684] In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0685] In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0686] In each of the above groups, one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; 1-6 One or more (e.g., 1, 2, 3, or 4) ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, or 4) ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more (e.g., 1, 2, 3, 4, or 5) ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus;

[0687] Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R eSame definition as above;

[0688] Wherein, when the ring atom is a phosphorus atom, the sulfur atom is optionally replaced by one or two selected from oxo and =NR e The group substituted; R e Same definition as above.

[0689] In formula (II-1), formula (II-2), formula (II-3), formula (II-4), formula (II-5), formula (II-6), and formula (II-6a),

[0690] In one embodiment, B1 is -CH(R9)-, optionally substituted 3- to 6-membered cycloalkylene, optionally substituted 3- to 6-membered heterocycloalkylene, optionally substituted 6-membered arylene, or 5- to 6-membered heteroarylene.

[0691] In one embodiment, B1 is -CH(R9)-.

[0692] In one embodiment, R9 is

[0693] In one embodiment, B1 is an optionally substituted 6-membered arylene.

[0694] In one embodiment, B1 is optionally substituted phenyl.

[0695] In one embodiment, L2 is A 1 -(B 1 ) f -(C 1 ) g -(B 2 ) h -(D 1 )-(B 3 ) i -(C 2 ) j -(B 4 ) k -A 2 ; Among them A 1 is the bond between the linker and B1; A 2 is the bond between W1 and the linker; B 1 、B 2 、B 3 and B 4 are each independently selected from optionally substituted C 1-2 Alkylene, optionally substituted C 1-3 Heteroalkylene, O, S and NR N ; R N is hydrogen, optionally substituted C 1-4 Alkyl, optionally substituted C 1-3Cycloalkyl, optionally substituted C 2-4 Alkenyl, optionally substituted C 2-4 alkynyl, optionally substituted 3 to 14 membered heterocycloalkyl, optionally substituted 6 to 10 membered aryl or optionally substituted C 1-7 Heteroalkyl; C 1 and C 2 are each independently selected from carbonyl, thiocarbonyl, sulfonyl or phosphoryl; f, g, h, i, j and k are each independently 0 or 1; and D 1 is an optionally substituted C 1-10 Alkylene, optionally substituted C 2-10 Alkenylene, optionally substituted C 2-10 alkylene, an optionally substituted 3- to 14-membered heterocycloalkylene, an optionally substituted 5- to 10-membered heteroarylene, an optionally substituted 3- to 8-membered cycloalkylene, an optionally substituted 6- to 10-membered arylene, an optionally substituted C 2-10 Polyethylene glycol or optionally substituted C 1-10 Heteroalkylene, or A 1 -(B 1 ) f -(C 1 ) g -(B 2 ) h -Connect to-(B 3 ) i -(C 2 ) j -(B 4 ) k -A 2 In one embodiment, L2 is where X a Is not present or N; R 14 Absent or hydrogen, optionally substituted C 1-6 Alkyl or optionally substituted C 1-3 cycloalkyl; and L 2 is absent, -C(=O)-, -S(=O)2-, optionally substituted C 1-4 Alkylene or optionally substituted C 1-4 Heteroalkylene, wherein X a 、R 14 or L 2 At least one of does not exist.

[0696] In one embodiment, L2 is Where o is 0 or 1; R 15 is hydrogen or optionally substituted C 1-6alkyl; Cy is an optionally substituted 3- to 8-membered cycloalkylene, an optionally substituted 3- to 8-membered heterocycloalkylene, an optionally substituted 6- to 10-membered arylene, or an optionally substituted 5- to 10-membered heteroarylene; and L 3 is absent, -C(=O)-, -S(=O)2-, optionally substituted C 1-4 Alkylene or optionally substituted C 1-4 Heteroalkylene.

[0697] In one embodiment, L2 is selected from the group consisting of:

[0698] In one embodiment, W1 is hydrogen, optionally substituted amino, optionally substituted C 1-4 Alkoxy, optionally substituted C 1-4 Hydroxyalkyl, optionally substituted C 1-4 aminoalkyl, optionally substituted C 1-4 Haloalkyl, optionally substituted C 1-4 Alkyl, optionally substituted C 1-4 Guanidinoalkyl, optionally C 0-4 alkyl-substituted 3- to 8-membered heterocycloalkyl, optionally substituted 3- to 8-membered cycloalkyl, or optionally substituted 3- to 8-membered heteroaryl.

[0699] In one embodiment, W1 is hydrogen. In one embodiment, W1 is optionally substituted amino. In one embodiment, W1 is -NHCH3 or -N(CH3)2. In one embodiment, W1 is optionally substituted C 1-4 In one embodiment, W1 is methoxy or isopropoxy. In one embodiment, W1 is optionally substituted C 1-4 In one embodiment, W1 is methyl, ethyl, isopropyl, tert-butyl or benzyl. In one embodiment, W1 is an optionally substituted amide. In one embodiment, W1 is an optionally substituted C 1-4 In one embodiment, W1 is an optionally substituted C 1-4 Aminoalkyl.

[0700] In one embodiment, W1 is selected from the group consisting of:

[0701] In one embodiment, R1 is hydrogen, C 1-6 Alkoxy or deuterated C 1-6 Alkoxy; R2 is hydrogen.

[0702] In one embodiment, R1 is hydrogen, methoxy, ethoxy, propoxy, or butoxy; and R2 is hydrogen.

[0703] In one embodiment, R1 is hydrogen; R2 is hydrogen.

[0704] In one embodiment, R1 is ethoxy; and R2 is hydrogen.

[0705] In one embodiment, R1 is hydrogen or C 1-6 Alkoxy; R2 is hydrogen.

[0706] In one embodiment, R1 is hydrogen; R2 is hydrogen.

[0707] In one embodiment, R3 is hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0708] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl.

[0709] In one embodiment, R3 is methyl, ethyl or propyl (including isopropyl or n-propyl).

[0710] In one embodiment, R3 is hydrogen, C 1-6 Alkyl or halogenated C 1-6 alkyl.

[0711] In one embodiment, R3 is hydrogen or C 1-6 alkyl.

[0712] In one embodiment, R3 is trifluoromethyl, trifluoroethyl or trifluoropropyl.

[0713] In one embodiment, R3 is ethyl.

[0714] In one embodiment, R3 is haloethyl. In one embodiment, R3 is trifluoroethyl.

[0715] In one embodiment, R 42 is methyl, R 43 It is trifluoromethyl.

[0716] In one embodiment, R 42 is hydrogen, R 43 It is trifluoromethyl.

[0717] In one embodiment, R 42 is fluorine, R 43 It is trifluoromethyl.

[0718] In one embodiment, R 42 is hydrogen, R 43 For fluorine.

[0719] In one embodiment, R 42 is hydrogen, R 43 It is a methyl group.

[0720] In one embodiment, R 42 and R 43 Together with the carbon atom to which it is attached, it forms a cyclopropyl or cyclobutyl group.

[0721] In one embodiment, R 42 and R 43 All are methyl.

[0722] In one embodiment, R 42 and R 43 Not methyl at the same time.

[0723] In one embodiment, R 42 is hydrogen; R 43 is hydrogen, halogen, substituted or unsubstituted C 1-6 alkyl.

[0724] In one embodiment, R 42 and R 43 Together with the carbon atom to which it is attached, it forms a substituted or unsubstituted cyclopropyl group, a substituted or unsubstituted cyclobutyl group, or a substituted or unsubstituted cyclopentyl group.

[0725] In one embodiment, R 42 and R 43 Together with the attached carbon atom, it forms an unsubstituted cyclopropyl group.

[0726] In one embodiment, R 44 For hydrogen.

[0727] In one embodiment, R 45 For hydrogen.

[0728] In one embodiment, R 46 For hydrogen.

[0729] In one embodiment, R 47 For hydrogen.

[0730] In one embodiment, Z4 is N or CH.

[0731] In one embodiment, Z5 is N or CH.

[0732] In one embodiment, Z6 is N or CH.

[0733] In one embodiment, R5 is

[0734] R 011 、R 012are independently hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R 011 、R 012 Together with the connected carbon atom, it forms a substituted or unsubstituted C 3-6 Cycloalkyl; the substitution is as defined herein;

[0735] X1 is a bond, S, O or N(R 013 );R 013 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl;

[0736] R 05 is hydrogen, deuterium or C 1-6 alkyl.

[0737] In one embodiment, R5 is hydrogen,

[0738] In one embodiment, R5 is hydrogen or methylpiperazinyl.

[0739] In one embodiment, R6 is substituted or unsubstituted C 3-6 cycloalkyl; the substitution is as defined herein.

[0740] In one embodiment, R6 is C 1-6 Preferably, R6 is a cyclopropyl group substituted by methyl. Preferably, R6 is a cyclopropyl group substituted by two methyl groups. For example, R6 is

[0741] In one embodiment, R6 is halogen-substituted or unsubstituted C 1-6 alkyl.

[0742] In one embodiment, R6 is substituted or unsubstituted C 1-6 Alkyl, substituted or unsubstituted C 3-6 Cycloalkyl.

[0743] In one embodiment, R6 is a halogen-substituted C 1-6 Alkyl, preferably F-substituted C 1-6 alkyl.

[0744] In one embodiment, R6 is substituted or unsubstituted cyclopropyl.

[0745] In one embodiment, R6 is C 1-6The cyclopropyl group substituted by an alkyl group is preferably a cyclopropyl group substituted by one or two methyl groups.

[0746] In one embodiment, R6 is

[0747] In one embodiment, R 12 For hydrogen.

[0748] In one embodiment, L1 is a 5- or 6-membered monocyclic heteroaryl.

[0749] In one embodiment, L1 is thiazolyl.

[0750] In one embodiment, R 11 for

[0751] Where X2 is NH, O or CR 013 ; X3, X4 are each independently N or CR 013 ;

[0752] R 013 、R 014 are independently hydrogen, halogen, oxo, C 1-6 Alkyl or C 1-6 Alkoxy; m is 1, 2, or 3;

[0753] R 015 、R 016 are independently hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl or -C 1-6 Alkyl-5 or 6-membered monocyclic heteroaryl; or R 015 、R 016 Together with the attached carbon atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclyl; the substitution is as defined herein.

[0754] In one embodiment, R 11 is pyrrolidinyl, isoxazolyl, triazolyl, pyridazinyl or triazolopyridinyl, wherein the pyrrolidinyl, isoxazolyl, triazolyl, pyridazinyl or triazolopyridinyl is optionally selected from oxo, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 3-6 Cycloalkyl, -C 1-4 The substituent of the alkylene-5 or 6-membered heteroaryl group is substituted.

[0755] In one embodiment, R 11 Select from the following groups:

[0756] In one embodiment, Select from the following groups:

[0757] In one embodiment, Y1 is N; and Y2 is CH.

[0758] In one embodiment, Y1 is CH; Y2 is N.

[0759] In one embodiment, Y1 is N; Y2 is N.

[0760] In one embodiment, Y1 is N + -O - ; Y2 is CH.

[0761] In one embodiment, Y1 is CH; Y2 is N + -O - .

[0762] In one embodiment, A compound represented by any one of formula (AIII-1) to formula (AIII-10) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0763] Where Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Yj4, Lj are as defined in any embodiment, The end is connected to L0.

[0764] In one embodiment, the structural unit Select from the following groups: (Preferably ),

[0765] In one embodiment, the structural unit Select from the following groups: (Preferably ),

[0766] In one embodiment, Yj4 is Rj 7 、Rj 71 、Rj11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Lj are as defined in any embodiment, and the * end is connected to the other fragments in D.

[0767] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0768] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0769] In one embodiment, Yj4 is

[0770] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0771] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0772] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the end is connected to other fragments in D. In one embodiment, when L0 is connected to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0773] In one embodiment, when L0 is linked to Yj4, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0774] In one embodiment, Yj4 is Rj 13 、Rj 11 、Rj12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Lj are as defined in any embodiment, and the * end is connected to the other fragments in D.

[0775] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0776] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0777] In one embodiment, Yj4 is The * end is connected to the other fragment in D.

[0778] In one embodiment, Rj 4 C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more selected from hydroxy, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 The alkylene group is substituted with a substituent of alkylene-OH).

[0779] In one embodiment, Rj 4 is cyclopropyl, cyclobutyl, cyclopentyl or 5- to 8-membered bicyclic heterocyclyl, which is optionally substituted by 1, 2 or 3 substituents selected from hydroxy, methyl, -CH2OH or -C(O)-NH(CH2CH2OH).

[0780] In one embodiment, Rj 4 for The * end is connected to the other fragment in D.

[0781] In one embodiment, Lj is a 5- or 6-membered heteroaryl.

[0782] In one embodiment, Lj is oxazolyl.

[0783] In one embodiment, Rj5 is C 1-4 alkyl.

[0784] In one embodiment, Rj5 is ethyl.

[0785] In one embodiment, when L0 is 4 When connected, Yj4 or Rj 4Any hydrogen atom on the 4 Any nitrogen atom on the 4 As defined in any embodiment.

[0786] In one embodiment, when L0 is 4 When connected, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D.

[0787] In one embodiment, when L0 is 4 When connected, Rj 4 for The end is connected to L0, and the * end is connected to other fragments in D.

[0788] In one embodiment, Yj4 is a 3- to 8-membered monocyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a phenyl group, wherein the 3- to 8-membered monocyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the phenyl group is optionally substituted with one or more selected from C 1-6 Alkyl, -C 1-4 Alkylene-hydroxy or -C 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group substituent, Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, and Lj are as defined in any embodiment.

[0789] In one embodiment, Yj4 is as defined in any of the embodiments.

[0790] In one embodiment, Rj 4 C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more selected from hydroxy, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 The alkylene group is substituted with a substituent of alkylene-OH).

[0791] In one embodiment, Rj 4 is cyclopropyl, cyclobutyl or cyclopentyl, said cyclopropyl, cyclobutyl or cyclopentyl being optionally substituted by 1, 2 or 3 substituents selected from hydroxy, methyl or -CH2OH.

[0792] In one embodiment, Rj4 for The * end is connected to the other fragment in D.

[0793] In one embodiment, when L0 is 5 , Lj or Rj 21 When connected, Yj4, Rj 5 , Lj or Rj 21 Any hydrogen atom on the 5 , Lj or Rj 21 Any nitrogen atom on the 5 , Lj, Rj 21 As defined in any embodiment.

[0794] In one embodiment, when L0 is linked to Yj4, Yj4 is in, The end is connected to L0, and the * end is connected to other fragments in D.

[0795] In one embodiment, when L0 is linked to Yj4, Yj4 is in, The end is connected to L0, and the * end is connected to other fragments in D.

[0796] In one embodiment, when L0 and Rj 5 When connected, Rj 5 for The end is connected to L0, and the * end is connected to other fragments in D.

[0797] In one embodiment, when L0 is linked to Lj, Lj is The end is connected to L0, and the * end is connected to other fragments in D.

[0798] In one embodiment, when L0 and Rj 21 When connected, Rj 21 for The end is connected to L0, and the * end is connected to other fragments in D.

[0799] In one embodiment, A compound represented by any one of Formula (AIA-1) to Formula (AIA-8) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0800] Where Rj 11 、Rj 12 、Rj 21 、Rj 22、Y1、Y2、Rj 5 、Rj 4 、Rj 3 、Rj 6 、Rj 61 、Rj 7 、Rj 71 , Lj is as defined in any embodiment, The end is connected to L0.

[0801] In one embodiment, A compound represented by any one of Formula (AIA-1-1) to Formula (AIA-1-7), Formula (AIA-2-1) to Formula (AIA-2-8), Formula (AIA-3-1) to Formula (AIA-3-5), Formula (AIA-4-1) to Formula (AIA-4-6), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0802] Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0803] Xj2 is S or O; Rj 111 is amino, hydroxy or hydrogen;

[0804] The end is connected to L0.

[0805] In one embodiment, A compound represented by any one of Formula (AIA-1a-1) to Formula (AIA-1a-4), Formula (AIA-1b-1) to Formula (AIA-1b-4), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0806] Where,

[0807] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0808] Xj2 is S or O;

[0809] The end is connected to L0.

[0810] In one embodiment, The compound represented by Formula (AIA-1a1-1) to Formula (AIA-1a1-4), Formula (AIA-1b1-1) to Formula (AIA-1b1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0811] Where,

[0812] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0813] Xj2 is S or O;

[0814] The end is connected to L0.

[0815] In one embodiment, A compound represented by any one of Formula (AIA-2a-1) to Formula (AIA-2a-4), Formula (AIA-2b-1) to Formula (AIA-2b-4), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0816] Where,

[0817] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0818] Rj 111 is an amino group or a hydroxy group;

[0819] The end is connected to L0.

[0820] In one embodiment, A compound represented by any one of Formula (AIA-2a1-1) to Formula (AIA-2a1-5), Formula (AIA-2b1-1) to Formula (AIA-2b1-3), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0821] Where,

[0822] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0823] Rj 111 is an amino group or a hydroxy group;

[0824] The end is connected to L0.

[0825] In one embodiment, The compound represented by formula (AIA-3a-1) to formula (AIA-3a-4), formula (AIA-3b-1) to formula (AIA-3b-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0826] Where,

[0827] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0828] Xj2 is S or O;

[0829] The end is connected to L0.

[0830] In one embodiment, The compound represented by Formula (AIA-3a1-1) to Formula (AIA-3a1-4), Formula (AIA-3b1-1) to Formula (AIA-3b1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0831] Where,

[0832] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0833] Xj2 is S or O;

[0834] The end is connected to L0.

[0835] In one embodiment, The compound represented by Formula (AIA-4a-1) to Formula (AIA-4a-4), Formula (AIA-4b-1) to Formula (AIA-4b-4) or its stable deuterated derivative or stereoisomer, or its pharmaceutically acceptable salt:

[0836] Where,

[0837] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0838] Rj 111 is an amino group or a hydroxy group;

[0839] The end is connected to L0.

[0840] In one embodiment, The compound represented by Formula (AIA-4a1-1) to Formula (AIA-4a1-4), Formula (AIA-4b1-1) to Formula (AIA-4b1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0841] Where,

[0842] Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 as defined in any embodiment;

[0843] Rj 111 is an amino group or a hydroxy group;

[0844] The end is connected to L0.

[0845] In one embodiment, A compound represented by any one of formula (AI-1) to formula (AI-6) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0846] Where Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 , Y1, Y2, Lj are as defined in any embodiment, The end is connected to L0.

[0847] In one embodiment, A compound represented by any one of Formula (AI-1-1) to Formula (AI-1-4), Formula (AI-2-1) to Formula (AI-2-4), Formula (AI-3-1) to Formula (AI-3-4), Formula (AI-4-1) to Formula (AI-4-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0848] Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 as defined in any embodiment;

[0849] Xj2 is S or O; Rj 111 is an amino group or a hydroxy group;

[0850] The end is connected to L0.

[0851] In one embodiment, A compound represented by any one of Formula (AIIA-1-1) to Formula (AIIA-1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0852] Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 13 as defined in any embodiment;

[0853] Xj2 is S or O;

[0854] The end is connected to L0.

[0855] In one embodiment, A compound represented by any one of Formula (AIIA-1a-1) to Formula (AIIA-1a-4), Formula (AIIA-1b-1) to Formula (AIIA-1b-4), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

[0856] Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 13 as defined in any embodiment;

[0857] Xj2 is S or O;

[0858] The end is connected to L0.

[0859] In one embodiment, Selected from the structures shown in Table 8,

[0860] Table 8

[0861] In one embodiment, Selected from D10, D11, D166, D168, D169-1, D170, D187, D187-A, D192-A, D192-C, D22, D282-A, D283, D284, D284-A, D7-2 , D285, D285-A, D285-B, D286, D286-A, D286-B, D287, D288, D288-A, D289, D290, D291, D292, D293, D294, D295 , D296, D297, D298, D299, D299-A, D3, D300, D301, D302, D303, D304, D305, D305-A, D306, D307, D308, D309, D3 1. D310, D311, D34, D35-A, D38-1, D4, D45-1, D47, D48, D52, D54, D56, D57-A, D6, D61, D63, D64-1, D67-A, D88.

[0862] In one embodiment, Selected from D10, D11, D166, D168, D169-1, D170, D22, D3, D31, D34, D35-A, D38-1, D4, D45-1, D47, D48, D52, D54, D56, D57-A, D6, D61, D63, D64-1.

[0863] In one embodiment, Selected from D31, D34, D35-A, D38-1, D47, D52, D56, D61, D64-1.

[0864] In one embodiment, L0 is a hydrophilic linker or a non-hydrophilic linker.

[0865] In one embodiment, Selected from the structure shown in formula (III-1) or formula (III-2):

[0866] -H2-L 1a -L 1b -L 1c -L 1d -D

[0867] (III-1)

[0868] -H2-L 1a -L 1b -L 1d (-L 1c -C(=O)-CH3)-D

[0869] (III-2)

[0870] as defined in any embodiment;

[0871] H2 is the antibody connecting unit, connected to Ab;

[0872] L 1a is a bond or derivative unit;

[0873] L 1b is a bond or a hydrophilic derivative unit;

[0874] L 1c is a bond or amino acid unit;

[0875] L 1d is a bond or drug-linking unit;

[0876] The L 1a , L 1b , L 1c , L 1d At least one is not a key;

[0877] H2, L 1a , L 1b , L 1c , L 1d Each independently is optionally substituted with a hydrophilic group.

[0878] In one embodiment, Selected from the structure shown in formula (III-1).

[0879] In one embodiment, the hydrophilic group is a 1- to 300-membered straight or branched heteroalkyl group-R end , wherein the 1-300 membered straight chain or branched heteroalkyl group refers to a 1-300 membered straight chain or branched alkyl group in which 1-100 carbon atoms at any position can be replaced by heteroatoms selected from N, O, and S, and the remaining carbon atoms can be optionally replaced by heteroatoms selected from deuterium, C 1-6 Alkyl, oxo (=O), thio (=S) group substitution, R end is H, deuterium, hydroxyl, carboxyl, amino, ester, amide, alkoxy or substituted amino.

[0880] In one embodiment, the hydrophilic group is composed of one or more groups selected from the group consisting of N, NH, N(CH3), O, C(O), NHC(O), N(CH3)C(O), C 1-6 Alkyl, polyethylene glycol, polysarcosine, glucose, glucuronic acid,

[0881] In one embodiment, the hydrophilic group is selected from:

[0882] Polysarcosine,

[0883] Among them, G0 is C 0-8 Hydrocarbon, C 0-8 Heteroalkyl, -NH-, O, S.

[0884] In one embodiment, G0 is C 0-8 Hydrocarbon, C 0-8 Heteroalkyl.

[0885] In one embodiment, G0 is a bond, C 1-4 Alkyl, C 1-4 Heteroalkyl.

[0886] In one embodiment, G0 is a bond, n-butyl.

[0887] In one embodiment, the hydrophilic group is selected from:

[0888] wherein G0 is as defined in any embodiment.

[0889] In one embodiment, the hydrophilic group is selected from:

[0890] wherein G0 is as defined in any embodiment.

[0891] In one embodiment, the hydrophilic group is selected from:

[0892] wherein G0 is as defined in any embodiment.

[0893] In one embodiment, the hydrophilic group is selected from:

[0894] In one embodiment, the hydrophilic group is selected from:

[0895] In one embodiment, H2 is selected from the group consisting of:

[0896] in,

[0897] *end is connected to the antibody, End and L 1a connected;

[0898] X is -O-(CH2) 0-6 -, -N(CH3)-, -O-, -CONH-, -CON(CH3)-,

[0899] R x1 、R x2 are independently hydrogen, C 1-6 Alkyl, halogen, deuterated, C 1-6 Alkoxy, C 1-6 Alkylene-NH-, (C 1-6 Alkyl) 2-N-,

[0900] R 31 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl,

[0901] R 32 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl,

[0902] Cy2 is a 5-10 membered heteroaryl group, C 6-10 Aryl, 3-10 membered heterocyclic group, C 3-10 Cycloalkyl,

[0903] The side chain is a hydrophilic group, and the hydrophilic group is as defined in any embodiment.

[0904] In one embodiment, R x1 、R x2 are independently hydrogen, C 1-4 Alkyl, halogen, deuterated, C 1-4 Alkoxy, C 1-4 Alkylene-NH-, (C 1-4 In one embodiment, R x1 、R x2 Each is independently hydrogen, methyl, halogen, deuterated, methoxy, methyl-NH-, (methyl)2-N-.

[0905] In one embodiment, R 31 is hydrogen, deuterium, halogen, cyano, or methyl. In one embodiment, R 31 For hydrogen.

[0906] In one embodiment, R 32 is hydrogen, deuterium, halogen, cyano, or methyl. In one embodiment, R 32 For hydrogen.

[0907] In one embodiment, Cy2 is a 5-10 membered heteroaryl, C 6-10 Aryl, 4-8 membered heterocyclic group, C 3-6In one embodiment, Cy2 is pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, cyclopropyl, cyclobutyl, or cyclopentyl.

[0908] In one embodiment, H2 is selected from the group consisting of: The side chain is a hydrophilic group, and the hydrophilic group is as defined in any embodiment. 31 、R 32 As defined in any embodiment, the * end is linked to the antibody, End and L 1a connected.

[0909] In one embodiment, H2 is selected from the group consisting of: *end is connected to the antibody, End and L 1a connected.

[0910] In one embodiment, H2 is selected from the group consisting of: *end is connected to the antibody, End and L 1a connected.

[0911] In one embodiment, H2 is selected from the group consisting of: *end is connected to the antibody, End and L 1a connected.

[0912] In one embodiment, H2 is *end is connected to the antibody, End and L 1a connected.

[0913] In one embodiment, L 1a is a bond, or is selected from C 1-6 Alkyl, C 1-6 Alkylene-C(=O), C 1-6 Alkylene-C(=O)NH, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 4-10 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-4 Alkylene-C 3-8 Cycloalkyl, C 1-4 Alkylene-4-10 membered heterocyclic group, C 1-4 Alkylene-C 6-10 Aryl, C 1-4Alkylene-5-10 membered heteroaryl, C 1-6 Heteroalkylene-C(=O), C 2-6 Alkenylene-C(=O), C 2-6 Alkynylidene-C(=O), C 3-8 Cycloalkyl-C(=O), 4-10 membered heterocyclyl-C(=O), C 6-10 Aryl-C(=O), 5-10 membered heteroaryl-C(=O), C 1-4 Alkylene-C 3-8 Cycloalkyl-C(=O), C 1-4 Alkylene-4-10 membered heterocyclyl-C(=O), C 1-4 Alkylene-C 6-10 Aryl-C(=O), C 1-4 Alkylene-5-10 membered heteroaryl-C(=O), C 1-6 Heteroalkylene-C(=O)NH, C 2-6 Alkenylene-C(=O)NH, C 2-6 Alkynylidene-C(=O)NH, C 3-8 Cycloalkyl-C(=O)NH, 4-10 membered heterocyclyl-C(=O)NH, C 6-10 Aryl-C(=O)NH, 5-10 membered heteroaryl-C(=O)NH, C 1-4 Alkylene-C 3-8 Cycloalkyl-C(=O)NH, C 1-4 Alkylene-4-10 membered heterocyclic group-C(=O)NH, C 1-4 Alkylene-C 6-10 Aryl-C(=O)NH, C 1-4 Alkylene-5-10 membered heteroaryl-C(=O)NH, the C 1-6 Alkyl, C 1-6 Alkyl...

Claims

1. Antibody-drug conjugate represented by formula (I): Ab is an antibody or fragment thereof that binds to the target; n is 1 to 20 and can be an integer or a non-integer; D is a fragment targeting RAS protein inhibitor; L0 is a linker connecting Ab and D.

2. The antibody-drug conjugate according to claim 1, wherein is a structure represented by Formula (VI-1), Formula (VI-2), Formula (VI-3), Formula (VI-4), Formula (VI-5) or Formula (VI-6) or a stable deuterated derivative thereof, or a stereoisomer thereof, in, In formula (VI-1), formula (VI-2), formula (VI-3), formula (VI-4), and formula (VI-5), the structural unit for X is In formula (VI-6), the structural unit for X is or, Structural unit for X is The end is connected to L0, and the * end is connected to other fragments in D. When L0 is connected to D, the hydrogen atom on D is replaced by L0, or the N atom on D is quaternized; Y1 and Y2 are each independently N, CH, or CR 4a , CR 4b or CYj4, where N can be oxidized (N + -O - ); Z4, Z5, and Z6 are each independently N, CR 13 , CR 14 , CR 48 , CR 49 or CR 50 ; R 13 and R 14 Each is independently hydrogen, halogen, C optionally substituted with one or more S1 1-6 Alkyl or -P(=O)-(C 1-6 alkyl)2, or R 13 and R 14 Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more S1 3-6 Cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more S1; R 48 、R 49 、R 50 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl; Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, or -P(=O)-(C 1-6 Alkyl) 2, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl are optionally substituted with one or more S1; R 4a for C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with one or more S1; Yj3 is NH-Rj 6 、O-Rj 6 NRj 62 Rj 6 、-C 1-4 Alkylene-NH-Rj 6 、-C 1-4 Alkylene-NRj 62 Rj 6 、-C 1-4 Alkylene-O-Rj 6 ; Rj 6 is hydrogen or C 1-6 alkyl; Rj 62 is hydrogen or C 1-6 alkyl; Rj 61 C 1-6 alkyl; R 4b is deuterium, halogen, C optionally substituted with one or more S1 1-6 Alkyl or C optionally substituted by one or more S1 1-6 heteroalkyl; Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1- 4-alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1- 4-alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group, C 6-10 aryl, 5 or 6-membered monocyclic heteroaryl or 8 to 10-membered bicyclic heteroaryl, the 3 to 8-membered monocyclic heterocyclic group, 5 to 15-membered tricyclic heterocyclic group, 7 to 12-membered bicyclic heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more S1; R 01 、R 02 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl or (C 1-6 Alkyl) 3-Si-, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, 3 to 8 membered monocyclic heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with one or more S1, or, R 01 、R 02 Together with the nitrogen atom to which it is connected, it forms a 5- to 15-membered tricyclic heterocyclic group, a 7- to 12-membered bicyclic heterocyclic group, or a 3- to 8-membered monocyclic heterocyclic group, wherein the 5- to 15-membered tricyclic heterocyclic group, the 7- to 12-membered bicyclic heterocyclic group, or the 3- to 8-membered monocyclic heterocyclic group is optionally substituted with one or more S1, or R 01 、R 02 Jointly formed Among them, R 001 、R 002 Together with the sulfur atom to which it is attached, it forms a 3- to 8-membered monocyclic heterocyclic group optionally substituted with one or more S1; R 03 、R 04 are independently hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl, the C 1-6 Alkyl, C 1- 6 alkoxy, C 2-6 Alkenyl or C 2-6 Alkynyl is optionally substituted with one or more S1, wherein optionally, said C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6, or R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more S1; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl; R 06 is hydrogen, deuterium or C 1-6 alkyl; Y4 is O or S; Y5 is O or S; is a single bond or a double bond; R m1 、R m3 Not present or hydrogen, R m2 is hydrogen, R m4 、R m5 are each independently hydrogen, halogen or C 1-6 Alkyl; or R m1 With R m2 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;or, R m1 With R m3 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;or, R m1 With R m4 Connect to form-CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -; R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl; L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with one or more S1; Y 10 is a bond, O, NH or N(C 1-4 alkyl); R 00 is hydrogen or C 1-6 alkyl; Rj 21 For hydrogen, deuterium, halogen, hydroxyl, amino, C 1-6 Alkyl, C optionally substituted with one or more S1 1-6 Heteroalkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g ; Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl, C optionally substituted with one or more S1 1-6 Heteroalkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g ; Rj f is hydrogen or C 1-6 alkyl; Rj g is hydrogen or C 1-6 alkyl; Rj 11 and Rj 12 Each is independently hydrogen, halogen or C optionally substituted by one or more S1 1-6 Alkyl; or Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with one or more S1 3-6 Cycloalkyl or a 3- to 8-membered heterocyclyl optionally substituted by one or more S1; R 44 、R 45 、R 46 、R 47 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl; or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by one or more S1, wherein one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, heteroaryl, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl and heteroaryl are optionally substituted with one or more S1; R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with one or more S1; R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl; the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; or R 07 and R 08 Together with the atoms to which it is attached, it forms a 3- to 8-membered heterocyclic group optionally substituted with one or more S1; In the above groups, S1 is independently selected from the following groups: deuterium, oxo (=O), thio (=S), CR e R f 、=NR e , SF5, halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 1-6 Heteroalkyl, C 3- 20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Heteroalkylene-C 1-4 Heteroalkylene-C 1-6 Heteroalkylene, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1- 4-alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1-6 Alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1- 4-alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-N=S(=O)(R g1 )(R h1 )、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by one or more groups selected from halogen, deuterium, cyano, hydroxyl or amino; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by one or more groups selected from Group S2; the nitrogen atom in the 5- or 6-membered monocyclic heteroaryl group may be optionally oxidized (N + -O - ); In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(O)H, -C(O)-C 1-4 Alkylene-OH, -C(=O)-C 3-6 monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group, -C(=O)-5 to 8-membered heterocyclic group; wherein the C 3-6 monocyclic cycloalkyl, the 3 to 6-membered monocyclic heterocyclic group, the 5 to 8-membered heterocyclic group, the phenyl group, the 5 or 6-membered monocyclic heteroaryl group, the 8 to 10-membered bicyclic heteroaryl group Optionally substituted by one or more groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1- 6 alkyl) 2, -C 1-4 Alkylene-P(=O)-(C 1-6 Alkyl)2, -C(O)C 1-6 Alkyl, -C(O)OC 1-6 Alkyl, -P(=O)-(C 1-6 alkyl)2; or Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2; In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2; In the above groups, R g1 、R h1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 Alkyl; or R g1 、R h1 Together with the connected sulfur atom, it forms a substituted or unsubstituted 3- to 8-membered monocyclic heterocyclic group; In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, cyano, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 alkyl)2, -(C=O)OC 1-6 Alkyl, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5; In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 3-6 Cycloalkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace; In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, one or more ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; 1-6 one or more ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; One or more ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 6- to 12-membered heteroarylheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above; Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

3. The antibody-drug conjugate according to claim 1 or 2, wherein It is a structure as shown in formula (II-5) or a stable deuterated derivative thereof, or a stereoisomer thereof: Where, Y1 is N or CH; wherein N can be oxidized (N + -O - ); Y2 is N or CH; wherein N can be oxidized (N + -O - ); R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1; L j -N(R 00 )C(=O)-、C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 00 is hydrogen or C 1-6 alkyl; Rj 21 For hydrogen, deuterium, halogen, hydroxyl, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl; Rj 22 For hydrogen, deuterium, halogen, C 1-6 Alkyl or C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 heteroalkyl; Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 4a C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1; Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene- NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl; R 06 is hydrogen, deuterium or C 1-6 alkyl; Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; Rj 3 For hydrogen, C 1-6 Alkyl or deuterated C 1-6 alkyl; or Y3, Rj 3 Together with the nitrogen atom to which they are attached, they form a nitrogen-containing 3- to 8-membered heterocyclic group optionally substituted by 1, 2, 3, 4, 5 or 6 Si; one ring atom of the nitrogen-containing 3- to 8-membered heterocyclic group is a nitrogen atom and optionally one or more ring atoms are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 of S1; R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1- 4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2; In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2; In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5; In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace; In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, one or more ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; 1-6 One or more ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 7- to 12-membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 3- to 20-membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 5- to 20-membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 5- or 6-membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 8- to 10-membered bicyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; one or more ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur, or phosphorus; Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above; Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

4. The antibody-drug conjugate according to claim 1 or 2, wherein The structure represented by formula (II-6a) or a stable deuterated derivative thereof, or a stereoisomer thereof: Where, Z1 is C(H), C(deuterium) or N; Z2 is C(H), C(deuterium) or N; Z3 is C(H), C(deuterium) or N; Z4, Z5, and Z6 are each independently N, CR 48 , CR 49 or CR 50 ; R 48 、R 49 、R 50 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; Y 10 is a bond, O, NH or N(C 1-4 alkyl); X is The end is connected to L0, and the * end is connected to other fragments in D; Y1 is N or CH; wherein N can be oxidized (N + -O - ); Y2 is N or CH; wherein N can be oxidized (N + -O - ); Rj 11 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; Rj 12 is hydrogen, halogen, C optionally substituted by 1, 2, 3, 4, 5 or 6 S1 1-6 Alkyl; or Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a C optionally substituted with 1, 2, 3, 4, 5 or 6 S1 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl optionally substituted by 1, 2, 3, 4, 5 or 6 S1; R 44 、R 45 、R 46 、R 47 are independently H, deuterium, halogen, C 1-4 Alkyl, C 1-4 Haloalkyl or C 1-4 alkoxy; R 3a C 1-6 Alkyl or deuterated C 1-6 alkyl; Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 4a C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1; Yj4 is hydrogen, -NR 01 R 02 、-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1- 4-alkylene-C(=O)-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-NR 01 R 02 、-C 1- 4-alkylene-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-N(R 06 )C(=O)-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-NR 01 R 02 、-OC 1-4 Alkylene-C(R 05 )R 03 R 04 、-OC 1-4 Alkylene-N(R 06 )C(=O)-R 03 、-OC(R 05 )R 03 R 04 、-C 1-4 Alkylene-NR 01 R 02 、-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-N(R 06 )C(=O)-NR 01 R 02 、-N(R 06 )C(=O)-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-NR 01 R 02 、-C 2-4 Alkynylidene-C(=O)-NR 01 R 02 、-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C(R 05 )R 03 R 04 、-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-CH=CR 01 R 02 、-C 2-4 Alkenylene-NR 01 R 02 、-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-NR 01 R 02 、-C 1-4 Alkylene-C 2-4 Alkenylene-C(R 05 )R 03 R 04 、-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkenylene-C 1-4 Alkylene-C(R 05 )R 03 R 04 、-C 1-4 Alkylene-C 2-4 Alkenylene-C 1-4 Alkylene-NR 01 R 02 、-C=CR 03 R 04 、-OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-5 to 15-membered tricyclic heterocyclic group, -OC 1-4 alkylene-7 to 12-membered bicyclic heterocyclyl, -O-3 to 8-membered monocyclic heterocyclyl, -O-5 to 15-membered tricyclic heterocyclyl, -O-7 to 12-membered bicyclic heterocyclyl, -N=S(=O)(R 06 )(-C 1-4 Alkylene-NR 01 R 02 )、-N(R 06 )-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)(R 06 )(=NR 06 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )(=NR 06 )、-S(=O)2(-C 1- 4-alkylene-NR 01 R 02 )、-S(=O)(-C 1-4 Alkylene-NR 01 R 02 )、-S(=O)2(-C 1-4 Alkylene-C(R 05 )R 03 R 04 )、-S(=O)(-C 1-4 Alkylene-C(R 05 )R 03 R 04 ), 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, the 3- to 8-membered monocyclic heterocyclyl, 5- to 15-membered tricyclic heterocyclyl, 7- to 12-membered bicyclic heterocyclyl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; R 01 、R 02 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, 3 to 6 membered cycloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; or R 01 、R 02 Together with the nitrogen atom to which it is attached, it forms a 5- to 15-membered tricyclic heterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 3- to 8-membered monocyclic heterocyclyl, wherein the 5- to 15-membered tricyclic heterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 3- to 8-membered monocyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 03 、R 04 are each independently selected from hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, the C 1-6 Alkyl, C 1-6 Alkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl is optionally substituted with 1, 2, 3, 4, 5 or 6 Si; wherein optionally, the C 1-6 Alkyl, C 1-6 The two hydrogen atoms on the same carbon atom of the alkoxy group are simultaneously replaced by -(CH2) j -substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or R 03 、R 04 Together with the carbon atom to which it is attached, it forms a 7- to 12-membered bicyclic heterocyclyl, a 5- to 15-membered tricyclic heterocyclyl, a 3- to 8-membered monocyclic heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, or an 8- to 10-membered bicyclic heteroaryl, wherein the 7- to 12-membered bicyclic heterocyclyl, the 5- to 15-membered tricyclic heterocyclyl, the 3- to 8-membered monocyclic heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, or the 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 Si; R 05 For hydrogen, deuterium, halogen, deuterated C 1-6 Alkyl or C 1-6 alkyl; R 06 is hydrogen, deuterium or C 1-6 alkyl; Y3 is -C(=O)Rj 4 、-C(=S)Rj 4 、-S(=O)(R 07 )(=NR 08 )、-S(=O)(R 07 )(R 08 )、-S(=O)2(R 07 )(R 08 ),-P(=O)(R 07 )(R 08 ), -C(=O)-C 1-4 Alkylene-NRj 4 -S(=O)(R 07 )(=NR 08 ), -C(=O)-C 1-4 Alkylene-N=S(=O)(R 07 )(R 08 ) or R 11 ; Rj 4 C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, wherein the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group, C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1; R 11 is a 3- to 10-membered heterocyclyl, a 5- or 6-membered monocyclic heteroaryl, an 8- to 10-membered bicyclic heteroaryl, a 6- to 12-membered heteroarylcycloalkyl, a 6- to 12-membered heteroarylcycloheterocyclyl, a 7- to 12-membered bicyclic heterocyclyl, or a 5- to 15-membered tricyclic heterocyclyl, wherein the 3- to 10-membered heterocyclyl, the 5- or 6-membered monocyclic heteroaryl, the 8- to 10-membered bicyclic heteroaryl, the 6- to 12-membered heteroarylcycloalkyl, the 6- to 12-membered heteroarylcycloheterocyclyl, the 7- to 12-membered bicyclic heterocyclyl, or the 5- to 15-membered tricyclic heterocyclyl is optionally substituted with 1, 2, 3, 4, 5, or 6 of S1; R 07 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; R 08 For hydrogen, deuterium, C 1-6 Alkyl or C 3-6 Cycloalkyl, the C 1-6 Alkyl, C 3-6 The cycloalkyl group is optionally substituted with one or more groups selected from the group consisting of deuterium, C 1-6 Alkyl, C 1-6 heteroalkyl, 5- or 6-membered monocyclic heteroaryl; Said S1 are independently selected from the following group: deuterium, oxo (=O), thio (=S), =CR e R f 、=NR e , halogen, cyano, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 1-6 Alkoxy, C 3-20 Cycloalkyl, 3 to 20 membered heterocyclic group, C 6-14 Aryl, 5- or 6-membered monocyclic heteroaryl, 8- to 10-membered bicyclic heteroaryl, -OC 3-20 Cycloalkyl, -O-3 to 20-membered heterocyclic group, -OC 6-14 Aryl, -O-5 or 6-membered monocyclic heteroaryl, -O-8 to 10-membered bicyclic heteroaryl, -C≡CC 3-20 Cycloalkyl, -C≡C-3 to 20-membered heterocyclic group, -C≡CC 6-14 Aryl, -C≡C-5 or 6-membered monocyclic heteroaryl, -C≡C-8 to 10-membered bicyclic heteroaryl, -C≡CC 1-4 Alkylene-C 3-20 Cycloalkyl, -C≡CC 1-4 Alkylene-3 to 20-membered heterocyclic group, -C≡CC 1-4 Alkylene-C 6-14 Aryl, -C≡CC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C≡CC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-C 3-20 Cycloalkyl, -C 1-4 Alkylene-OC 3-20 Cycloalkyl, -C 1-4 Alkylene-3 to 20 membered heterocyclic group, -C 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -C 1- 4-alkylene-C 6-14 Aryl, -C 1-4 Alkylene-OC 6-14 Aryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-hydroxyl, -OC 1-4 Alkylene-cyano, -OC 1-4 Alkylene-C 1-6 Alkyl, -OC 1-4 Alkylene-C 1-6 Alkoxy, -OC 1-4 Alkylene-C 3-20 Cycloalkyl, -OC 1-4 Alkylene-OC 3-20 Cycloalkyl, -OC 1-4 Alkylene-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-O-3 to 20-membered heterocyclic group, -OC 1-4 Alkylene-C 6-14 Aryl, -OC 1-4 Alkylene-OC 6-14 Aryl, -OC 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-O-5 or 6-membered monocyclic heteroaryl, -OC 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -OC 1-4 Alkylene-O-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-20 Cycloalkyl, -S(=O)2-3 to 20-membered heterocyclic group, -C(=O)OC 1-6 Alkyl, -C(=O)OC 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-20 Cycloalkyl, -C(=O)-C 6-14 Aryl, -NR a1 R b1 、-C(=O)-NR a1 R b1 、-C(=O)-NR d1 -C 1-4 Alkylene-R c1 、-OR c1 、-C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-20 Cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 20-membered heterocyclic group, -C 1-4 Alkylene-C(=O)OC 1-6 Alkyl, -C 1-4 Alkylene-C(=O)OC 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 1- 6-alkyl, -C 1-4 Alkylene-C(=O)-C 3-20 Cycloalkyl, -C 1-4 Alkylene-C(=O)-C 6-14 aryl, -C(=O)-5 or 6-membered monocyclic heteroaryl, -C(=O)-8 to 10-membered bicyclic heteroaryl, -C(=O)-C 1-6 Alkylene-C 3-20 Cycloalkyl, -C(=O)-C 1-6 Alkylene-3 to 20-membered heterocyclic group, -C(=O)-C 1-6 Alkylene-C 6-14 Aryl, -C(=O)-C 1-6 Alkylene-5 or 6-membered monocyclic heteroaryl, -C(=O)-C 1-6 Alkylene-8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-NR a1 R b1 、-C 1-4 Alkylene-C(=O)-NR a1 R b1 、-C≡CC(=O)-NR a1 R b1 、-C≡CC 1-4 Alkylene-C(=O)-NR a1 R b1 、-C 1-4 Alkylene-OR c1 、-C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2, -C 1-4 Alkylene-NR d1 -C(=O)-R c1 、-C 1-4 Alkylene-NR d1 -C(=O)-NR a1 R b1 、- C 1-4 Alkylene-NR d1 -S(=O)2-R c1 、-C 1-4 Alkylene-S(=O)2-NR a1 R b1 、-C 1-4 Alkylene-NR d1 -S(=O)2-NR a1 R b1 、-NR d1 -C(=O)-R c1 、-NR d1 -C(=O)-C 1-4 Alkylene-R c1 、-NR d1 -C(=O)-NR a1 R b1 、-NR d1 -S(=O)2-R c1 、-S(=O)2-NR a1 R b1 、-NR d1 -S(=O)2-NR a1 R b1 、-P(=O)-(C 1-6 Alkyl) 2; wherein the C 1-6 Alkyl, the C 1-6 Alkoxy, the C 2-6 Alkenyl, the C 2-6 Each alkynyl group is independently optionally substituted by 1, 2 or 3 groups selected from halogen, deuterium, cyano or hydroxy; 3-20 Cycloalkyl, the 3 to 20 membered heterocyclic group, the C 6-14 The aryl group, the 5- or 6-membered monocyclic heteroaryl group, and the 8- to 10-membered bicyclic heteroaryl group are each independently optionally substituted by 1, 2, 3 or 4 groups selected from Group S2; In the above groups, each R a1 、R b1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, -C 1-4 Alkylene-hydroxyl, -C 1-4 Alkylene-cyano, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl, -C 1-4 Alkylene-8 to 10-membered bicyclic heteroaryl, -S(=O)2-C 1-6 Alkyl, -S(=O)2-C 3-6 Monocyclic cycloalkyl, -S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-S(=O)2-C 1-6 Alkyl, -C 1-4 Alkylene-S(=O)2-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-S(=O)2-3 to 6-membered monocyclic heterocyclic group, -C(=O)-C 1-6 Alkyl, -C(=O)-C 3-6 Monocyclic cycloalkyl, -C(=O)-3 to 6-membered monocyclic heterocyclic group; wherein the C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2; or Each R a1 and R b1 Together with the nitrogen atoms to which they are attached, they form a 3- to 20-membered heterocyclic group; wherein the 3- to 20-membered heterocyclic group is independently optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1- 6-alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 Alkyl)2; In the above groups, each R d1 Each independently is H, C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, each R c1 Each independently is H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkyl, -C 1-4 Alkylene-deuterated C 1-6 Alkyl, -C 1-4 Alkylene-C 1-6 Alkoxy, -C 1-4 Alkylene-halogenated C 1-6 Alkoxy, -C 1-4 Alkylene-deuterated C 1-6 Alkoxy, C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-C 3-6 Monocyclic cycloalkyl, -C 1-4 Alkylene-OC 3-6 Monocyclic cycloalkyl, 3 to 6 membered monocyclic heterocyclic group, -C 1-4 Alkylene-3 to 6-membered monocyclic heterocyclic group, -C 1-4 Alkylene-O-3 to 6-membered monocyclic heterocyclic group, phenyl, -C 1-4 Alkylene-phenyl, 5 or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-5 or 6-membered monocyclic heteroaryl, 8 to 10-membered bicyclic heteroaryl or -C 1-4 Alkylene-8 to 10 membered bicyclic heteroaryl; said C 3-6 The monocyclic cycloalkyl, the 3 to 6 membered monocyclic heterocyclic group, the phenyl, the 5 or 6 membered monocyclic heteroaryl, the 8 to 10 membered bicyclic heteroaryl are optionally substituted by 1 or 2 groups selected from the group consisting of halogen, hydroxy, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1- 6 alkyl)2; In the above groups, each group of S2 is independently selected from the following groups: deuterium, oxo (C=O), thio (=S), CR e R f 、=NR e , halogen, hydroxyl, carboxyl, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -(C=O)-NHC 1-6 Alkyl, -(C=O)-N(C 1-6 Alkyl)2, -C 1-4 Alkylene-P(=O)-(C 1-6 alkyl)2, -P(=O)-(C 1-6 alkyl)2, -(C=O)C 1-6 Alkyl, SF5; In the above groups, the -C 1-4 Alkylene- is unsubstituted; or -C 1-4 1, 2, 3 or 4 hydrogen atoms on the alkylene group are independently selected from halogen, cyano, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 Alkyl, deuterated C 1-6 alkyl, -CH2-hydroxy, -CH2-cyano, phenyl; or -C 1-4 Alkylene - two hydrogen atoms on the same carbon atom are replaced by -(CH2) j -Pick Substituted to form a cycloalkyl group, wherein j is 2, 3, 4, 5 or 6; or -C 1-4 The two hydrogen atoms on the same carbon atom of the alkylene group are simultaneously replaced by =CR e R f replace; In the above groups, R e are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, R f are independently H, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 alkyl; In the above groups, one or more ring atoms of the 3- to 8-membered heterocyclic group, the 3- to 10-membered heterocyclic group or the 3- to 8-membered monocyclic heterocyclic group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; 1-6 One or more ring atoms of the heteroalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 7-12 membered bicyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 3-20 membered heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5-20 membered heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5 or 6 membered monocyclic heteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; One or more ring atoms of the cycloheteroaryl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 3- to 6-membered monocyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 5- to 15-membered tricyclic heterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 6- to 12-membered heteroarylcycloalkyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; one or more ring atoms of the 6- to 12-membered heteroarylcycloheterocyclyl group are heteroatoms selected from nitrogen, oxygen, sulfur or phosphorus; Wherein, when the ring atom is a sulfur atom, the sulfur atom is optionally substituted by one or two selected from oxo and =NR e The group substituted; R e Same definition as above; Wherein, when the ring atom is a phosphorus atom, the phosphorus atom is optionally substituted by one or two groups selected from oxo and =NR e The group substituted; R e Same definition as above.

5. The antibody-drug conjugate according to any one of claims 1 to 4, wherein Z4, Z5, and Z6 are each independently CR 13 , CR 14 , CR 48 , CR 49 or CR 50 , R 13 、R 14 、R 48 、R 49 or R 50 As defined in any one of claims 2 to 4.

6. The antibody-drug conjugate according to any one of claims 1 to 5, wherein Z4, Z5, and Z6 are each independently CH.

7. The antibody-drug conjugate according to any one of claims 1 to 6, wherein: Rj 5 For hydrogen, C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 1-6 Alkyl, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, S1 is as defined in any one of claims 2 to 6 or this claim; S1 is independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkyl, NH(C 1-4 alkyl), N(C 1-4 Alkyl) 2, the C 1- 4-alkyl is optionally substituted by 1, 2 or 3 substituents selected from OH, NH2.

8. The antibody-drug conjugate according to any one of claims 1 to 7, wherein Rj 5 For hydrogen, C 1-6 Alkyl, C 3-6 Cycloalkyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHC 1-6 Alkyl or -C 1-4 Alkylene-C 1-6 Alkoxy, Preferably, Rj 5 is ethyl, cyclopropyl, -(CH2)2OH, -(CH2)3OH, -(CH2)2-NH(CH3) or -(CH2)2-OCH3, When L0 and Rj 5 When connected, Rj 5 Any hydrogen atom on Rj is replaced by L0, and the Rj 5 As defined in any one of claims 2 to 7 or this claim, When L0 and Rj 5 When connected, preferably, Rj 5 for More preferably, Rj 5 for The end is connected to L0, and the * end is connected to other fragments in D.

9. The antibody-drug conjugate according to any one of claims 1 to 8, wherein Y1 and Y2 are each independently N, N + -O - , CH or CR 4b , R 4b For deuterium, halogen, C 1-6 Alkyl or C 1-6 heteroalkyl; Preferably, Y1 is N or N + -O - , Preferably, Y2 is CH; When L0 is connected to Y1, any hydrogen atom on Y1 is replaced by L0, or any N atom on Y1 is quaternized, and Y1 is as defined in any one of claims 2 to 8 or this claim, When L0 is connected to Y1, preferably, Y1 is N + .

10. The antibody-drug conjugate according to any one of claims 1 to 10, wherein: R 4a for Yj3 is NH-Rj 6 、O-Rj 6 NRj 62 Rj 6 、-C 1-4 Alkylene-NH-Rj 6 、-C 1-4 Alkylene-NRj 62 Rj 6 、-C 1-4 Alkylene-O-Rj 6 , where Rj 6 、Rj 62 、Rj 61 As defined in claim 2, the * end is connected to the other fragment in D.

11. The antibody-drug conjugate according to any one of claims 1 to 10, wherein: R 4a For hydroxyl or C 1-4 Heteroalkyl (e.g., methoxy, methylamino) substituted C 1-6 alkyl, Preferably, R 4a is -CH(CH3)OCH3 or -CH(CH3)NHCH3, When L0 and R 4a When connected, R 4a Any hydrogen atom on the 4a Any nitrogen atom on the 4a As defined in any one of claims 2 to 10 or this claim; When L0 and R 4a When connected, preferably, R 4a for The end is connected to L0, and the * end is connected to other fragments in D.

12. The antibody-drug conjugate according to any one of claims 1 to 11, wherein: Yj4 is -C 2-4 Alkynylidene-C 1-4 Alkylene-NR 01 R 02 、-C 2-4 Alkynylidene-C 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, -OC 1-4 Alkylene-3 to 8-membered monocyclic heterocyclic group, 3 to 8-membered monocyclic heterocyclic group, 7 to 12-membered bicyclic heterocyclic group or C 6-10 Aryl, the 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group, C 6-10 Aryl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, R 01 、R 02 are independently hydrogen, C 1-6 alkyl or 3 to 8-membered monocyclic heteroalkyl, the C 1-6 Alkyl or 3 to 8 membered monocyclic heteroalkyl is optionally substituted with 1, 2, 3, 4, 5 or 6 S1, S1 is as defined in any one of claims 2 to 11; Preferably, Yj4 is 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group or phenyl group, wherein the 3 to 8 membered monocyclic heterocyclic group, 7 to 12 membered bicyclic heterocyclic group or phenyl group is optionally substituted by one or more selected from C 1-6 Alkyl, -C 1-4 Alkylene-hydroxy, -C(=O)-C 1-4 Alkylene-hydroxy or -C 1-4 Substitutents of alkylene-3 to 8-membered monocyclic heterocyclic group, Rj 7 or Rj 13 Each independently NR 01 R 02 , 4- to 5-membered monocyclic heterocyclic group, oxo 5-membered heterocyclic group -Lj1-Lj2-Rj 14 , 6-membered heterocyclic group-Lj1-Lj2-Rj 14 or oxo 7-membered heterocyclic group-Lj1-Lj2-Rj 14 , the 4 to 5 membered monocyclic heterocyclic group is optionally substituted by hydroxyl, cyano or amino, the Rj 7 Optionally -C 1-4 Alkylene-OH or -C 1-4 Alkylene-NH-Rj 6 replace, Rj 71 For hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-Rj 6 , Rj 8 is O or NH, Xj1 is -O-, -CRj 91 Rj 92 -or-NRj 10 -, mj is 1 or 2, Lj1 and Lj2 are each independently -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-, Rj 14 C 1-6 heteroalkyl, Rj 6 is hydrogen or C 1-6 alkyl, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -NRj c Rj d 、-C 1-4 Alkylene-NRj c Rj d 、-C 1-4 Alkylene-OH, -C(O)-NRj a Rj b or -C(O)-NRj c Rj d , the -C 1-4 Alkylene - optionally substituted with methyl; Rj 10 For hydrogen, C 1-6 Alkyl, -C(O)-C 1-6 Alkyl, -C(O)-C 1-4 Alkylene-NRj f Rj g or -C(O)-C 1-4 Alkylene-OH; Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-6 Alkyl, -C 1-4 Alkylene-OH, 5- to 8-membered heterocyclic group, -C(O)-5- to 8-membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from Rj 42 Substituents substituted, Rj 42 Methyl, -NRj f Rj g 、-C(O)Rj e or -C(O)ORj e , Rj e C 1-6 alkyl, Rj f 、Rj g are each independently hydrogen or C 1-6 alkyl; Preferably, Yj4 is Rj 7 、Rj 71 、Rj 13 As defined in this claim; Preferably, Rj 71 is hydrogen; Preferably, Rj 7 or Rj 13 Each independently NR 01 R 02 or oxo 6-membered heterocyclic group-Lj1-Lj2-Rj 14 , the Rj 7 Optionally -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-Rj 6 Replace, Rj 8 、Xj1、mj、R 01 、R 02 、Lj1、Lj2、Rj 14 As defined in this claim, the * end is connected to the other segments in D; More preferably, Rj 7 for Rj 8 , Xj1, mj as defined in the present claims, preferably, Xj1 is -CRj 91 Rj 92 -or-NRj 10 -, Rj 91 、Rj 92 、Rj 10 As defined in this claim, the * end is connected to the other segments in D; Preferably, R 01 、R 02 are independently hydrogen, C 1-4 alkyl or 4- to 7-membered monocyclic heteroalkyl, Preferably, R 01 、R 02 are each independently hydrogen, methyl, ethyl, n-propyl, isopropyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl, Preferably, R 01 、R 02 are each independently methyl, isopropyl or tetrahydropyranyl, Preferably, Rj 6 is hydrogen or C 1-4 alkyl, Preferably, Rj 6 is hydrogen, methyl, ethyl, n-propyl or isopropyl, Preferably, Rj 6 is hydrogen; Preferably, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -NRj c Rj d 、-C 1-4 Alkylene-NRj c Rj d 、-C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in this claim, More preferably, Rj 91 、Rj 92 Each is independently hydrogen, hydroxy, cyano, -CH2OH, -CH2NH2; Preferably, Rj 91 is hydrogen, hydroxy or cyano, preferably, Rj 91 is cyano, Preferably, Rj 92 is hydrogen, amino, -CH2OH, -CH2NH2 or -C(O)NHCH2CH2OH; Preferably, Rj 91 、Rj 92 Not simultaneously hydrogen; Preferably, Rj 10 For hydrogen, C 1-4 Alkyl, -C(O)-C 1-4 Alkyl, -C(O)-C 1-4 Alkylene-NH2, -C(O)-C 1-4 Alkylene-NHC 1-4 Alkyl, -C(O)-C 1-4 Alkylene-N(C 1-4 alkyl)2 or -C(O)-C 1-4 Alkylene-OH, Preferably, Rj 10 is hydrogen, methyl, ethyl, n-propyl, isopropyl, -C(O)CH3, -C(O)CH2CH3, -C(O)CH(CH3)2, -C(O)CH2NH2, -C(O)CH2CH2NH2, -C(O)CH2NHCH3, -C(O)CH2N(CH3)2, -C(O)CH2CH2NHCH3, -C(O)CH2OH or -C(O)CH2CH2OH, Preferably, Rj 10 is hydrogen, methyl, -C(O)CH3, -C(O)CH2OH or -C(O)CH2NH2; More preferably, Rj 10 is hydrogen, -C(O)-C 1-4 Alkylene-NH2 or -C(O)-C 1-4 Alkylene-OH, More preferably, Rj 10 is hydrogen, -C(O)CH2OH or -C(O)CH2NH2; More preferably, Rj 10 is -C(O)CH2OH or -C(O)CH2NH2; Preferably, Rj a 、Rj b are each independently hydrogen or C 1-4 alkyl, Preferably, Rj a 、Rj b are each independently hydrogen; Preferably, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from Rj 42 Substituents substituted, said Rj 42 As defined in this claim, Preferably, Rj c 、Rj d are each independently hydrogen, methyl, ethyl, n-propyl, isopropyl, -C(O)CH3, -C(O)CH2CH3, -C(O)CH(CH3)2, -C(O)CH2OH or -C(O)CH2CH2OH, Preferably, Rj 42 Methyl, -NRj f Rj g 、-C(O)Rj e or -C(O)ORj e , Rj f 、Rj g 、Rj e As defined in this claim, Preferably, Rj e C 1-4 alkyl, Preferably, Rj e is methyl; Preferably, Rj f 、Rj g are each independently hydrogen or C 1-4 alkyl, Preferably, Rj f 、Rj g are each independently hydrogen or methyl; Preferably, Rj 7 for Rj 91 、Rj 92 are each independently hydrogen, hydroxy, cyano, -NH2, -CH2NH2, -CH2NH(CH3), -CH2OH or -C(O)-NH(CH2CH2OH), Rj 91 、Rj 92 Not all are hydrogen, and mj is 1 or 2; Preferably, Rj 7 for Rj 10 is hydrogen or -C(O)CH2OH, mj is 1 or 2; Preferably, Rj 7 for Among them, the * end is connected to other segments in D; Preferably, Rj 13 for Oxo 6-membered heterocyclic group-Lj1-Lj2-Rj 14 , Rj 8 、Xj1、mj、Lj1、Lj2、Rj 14 As defined in this claim, the * end is connected to the other segments in D; Preferably, Xj1 is -CRj 91 Rj 92 -, Rj 91 、Rj 92 As defined in this claim; Preferably, Rj 91 、Rj 92 are independently hydrogen, hydroxy, cyano, amino, -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NHC 1- 4-alkyl, -C 1-4 Alkylene-N(C 1-4 alkyl)2, and Rj 91 、Rj 92 Not hydrogen at the same time, Preferably, Rj 91 is cyano, Rj 92 is -CH2NH2; Preferably, mj is 1; Preferably, Lj1 is -CH2CH2-O-; Preferably, Lj2 is -CH2CH2-NH-; Preferably, Rj 14 C 1-4 heteroalkyl, Preferably, Rj 14 -CH2OCH3, -CH2CH2OCH3, Preferably, Rj 13 for *end is connected to other segments in D; Preferably, Yj4 is a 5- to 7-membered nitrogen-containing monocyclic heterocyclic group, a 9- to 10-membered nitrogen-containing bicyclic heterocyclic group or a phenyl group, wherein the 5- to 7-membered nitrogen-containing monocyclic heterocyclic group, the 9- to 10-membered nitrogen-containing bicyclic heterocyclic group or the phenyl group is optionally substituted by one or more selected from C 1-4 Alkyl, -methylene-hydroxy, -C(=O)C 1-4 substituted by a substituent of an alkylene-OH or -methylene-5 to 7-membered nitrogen-containing monocyclic heterocyclic group, Preferably, Yj4 is piperidinyl, piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclic group or phenyl, and the piperidinyl, piperazinyl, 9-10 membered nitrogen-containing bicyclic heterocyclic group or phenyl is optionally substituted by one or more substituents selected from methyl, -methylene-hydroxy, -methylene-morpholinyl, -C(=O)CH2OH or -methylene-piperazinyl, Preferably, Yj4 is *end is connected to other segments in D; When L0 is connected to Yj4, any hydrogen atom on Yj4 is replaced by L0, or any N atom on Yj4 is quaternized, and Yj4 is as defined in any one of claims 2 to 11 or this claim; When L0 is connected to Yj4, preferably, Yj4 is Further preferably, Yj4 is in, The end is connected to L0, and the * end is connected to other fragments in D.

13. The antibody-drug conjugate according to any one of claims 1 to 12, wherein: Structural unit for X is Preferably, X is Preferably, X is Among them, Z4, Z5, Z6, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any one of claims 2 to 12, The end is connected to L0, and the * end is connected to other fragments in D; Preferably, the structural unit for Still more preferably, the structural unit for Still more preferably, the structural unit for Among them, Y1, Y2, R 4a 、Yj4、Rj 5 As defined in any one of claims 2 to 12, The end is connected to L0, and the * end is connected to other fragments in D.

14. The antibody-drug conjugate according to any one of claims 1 to 13, wherein: Lj is -NHC(=O)-, -N(C 1-6 alkyl)C(=O)-, C 6-10 aryl, 5- or 6-membered monocyclic heteroaryl or 8- to 10-membered bicyclic heteroaryl, the C 6-10 Aryl, 5- or 6-membered monocyclic heteroaryl, or 8- to 10-membered bicyclic heteroaryl is optionally substituted with 1, 2, 3, 4, 5, or 6 S1, wherein S1 is as defined in any one of claims 2 to 13; Preferably, S1 is independently selected from deuterium, halogen, cyano, hydroxyl, amino, C 1-4 alkyl; Preferably, Lj is phenyl, oxazolyl or thiazolyl, said phenyl being optionally substituted by hydroxyl or amino, Preferably, Lj is phenyl, *end is connected to other segments in D; Preferably, Lj is oxazolyl or thiazolyl, Preferably, Lj is *end is connected to other segments in D; Y 10 is O, NH, NCH3, NCH2CH3 or NCH(CH3)2, Preferably, Y 10 is O or NH; When L0 is connected to Lj, any hydrogen atom on Lj is replaced by L0, or any N atom on Lj is quaternized, and Lj is as defined in any one of claims 2 to 13 or this claim; When L0 is connected to Lj, preferably, Lj is Preferably, Lj is The end is connected to L0, and the * end is connected to other fragments in D.

15. The antibody-drug conjugate according to any one of claims 1 to 14, wherein: Rj 21 、Rj 22 are independently hydrogen, C 1-6 Alkyl, -NRj f Rj g or -OC 1-4 Alkylene-NRj f Rj g , Rj f 、Rj g As defined in claim 2 or this claim, Preferably, Rj f 、Rj g are each independently hydrogen, methyl, ethyl, n-propyl or isopropyl; Preferably, Rj 21 、Rj 22 Each independently represents hydrogen, amino, -NH(C 1-4 Alkyl), -N(C 1-4 Alkyl)2, -OC 1-4 Alkylene-NH(C 1-4 alkyl) or -OC 1-4 Alkylene-N(C 1-4 Alkyl)2, Preferably, Rj 21 is hydrogen, amino, -NH(CH3), -OCH2CH2NHCH3 or -OCH2CH2N(CH3)2, Preferably, Rj 22 is hydrogen; When L0 and Rj 21 When connected, Rj 21 Any hydrogen atom on the 21 Any nitrogen atom on the 21 As defined in any one of claims 2 to 14 or this claim; When L0 and Rj 21 When connected, preferably, Rj 21 -NH-, -N(CH3)-, More preferably, Rj 21 -NH-, -N(CH3)-, in, The end is connected to L0, and the * end is connected to other fragments in D.

16. The antibody-drug conjugate according to any one of claims 1 to 15, wherein: Rj 11 、Rj 12 are independently hydrogen, deuterated C 1-6 Alkyl or C 1-6 alkyl, Preferably, Rj 11 and Rj 12 are each independently methyl or deuterated methyl, Preferably, Rj 11 and Rj 12 Together with the carbon atom to which it is attached, it forms a cyclopropyl group; R 44 、R 45 、R 46 、R 47 are independently hydrogen, deuterium, halogen, C 1-4 Alkyl or C 1-4 haloalkyl, Preferably, R 44 、R 45 、R 46 、R 47 For hydrogen.

17. The antibody-drug conjugate according to any one of claims 1 to 16, wherein: Y3 is -C(=O)Rj 4 or R 11 , Rj 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more Rj 41 replace, R 11 is a 5- or 6-membered monocyclic heteroaryl or an 8- to 10-membered bicyclic heteroaryl, wherein the 5- or 6-membered monocyclic heteroaryl or the 8- to 10-membered bicyclic heteroaryl is optionally substituted by one or more Rj 41 replace, Rj 41 C 1-6 Alkyl, hydroxyl, SF5, NRj c Rj d 、-P(=O)(C 1-6 Alkyl)2, -C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-6 Alkyl, C 1-6 Halogenated alkyl, phenyl, 5- or 6-membered monocyclic heteroaryl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, wherein the 5 to 8 membered heterocyclic group is Selected by one or more Rj 42 replace, Rj 42 C 1-6 Alkyl, halogenated C 1-6 Alkyl, -NH2, -NHC 1-6 Alkyl, -N(C 1-6 Alkyl)2, -C(O)C 1-6 Alkyl or -C(O)OC 1-6 alkyl; Preferably, Rj 4 C 6-10 Aryl, 5 or 6 membered monocyclic heteroaryl, C 3-6 Cycloalkyl, 3 to 8 membered heterocyclic group or -CRj a Rj b -NRj c Rj d , the C 6-10 Aryl, 5 or 6 membered monocyclic heteroaryl, C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more Rj 41 Substitution, the Rj a 、Rj b 、Rj c 、Rj d 、Rj 41 As defined in this claim, Still more preferably, Rj 4 is a 5- to 8-membered oxa-heterocyclic group, preferably a 5- to 8-membered oxa-fused heterocyclic group; Or preferably, Rj 4 C 3-6 Cycloalkyl, the C 3-6 The cycloalkyl group is optionally substituted with 1, 2, 3, 4 or 5 Rj 41 Replace, Rj 41 As defined in the claims, preferably, Rj 41 For hydroxyl, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 Alkylene-OH), preferably, Rj 41 is hydroxy, methyl, -CH2OH or -C(O)-NH(CH2CH2OH); Or preferably, Rj 4 -CRj a Rj b -NRj c Rj d , Rj a 、Rj b 、Rj c 、Rj d As defined in the claims, preferably, Rj a 、Rj b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl or -C(O)-C 1-4 Alkylene-OH; or preferably, Rj 4 -CRj a Rj b -NRj c Rj d , Rj a 、Rj b are each independently hydrogen or C 1-6 Alkyl, Rj c 、Rj d are independently hydrogen, C 1-6 Alkyl or -C(O)-tetrahydropyrrole, wherein the tetrahydropyrrole is optionally substituted with 1, 2, 3, 4 or 5 Rj 42 Replace, Rj 42 is methyl or -C(O)OCH3; Preferably, Rj 41 C 1-4 Alkyl, hydroxyl, NRj c Rj d 、-C 1-4 Alkylene-OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in this claim, Preferably, Rj 41 is methyl, ethyl, hydroxy, amino, CH2OH, CH2CH2OH or -C(O)-NRj c Rj d , the Rj c 、Rj d As defined in this claim, Preferably, Rj a 、Rj b are each independently hydrogen, isopropyl, cyclobutyl or cyclopentyl; Preferably, Rj c 、Rj d are independently hydrogen, -C(O)H, C 1-4 Alkyl, C 1-4 Halogenated alkyl, phenyl, pyridyl, -C 1- 4-alkylene-OH, -C(O)-5 to 6-membered heterocyclic group or -C(O)-C 1-4 Alkylene-OH, the 5 to 6 membered heterocyclic group is optionally replaced by one or more Rj 42 Substitution, the Rj 42 As defined in this claim, Preferably, Rj c 、Rj d Each is independently hydrogen, methyl, -C(=O)CH2OH, -C(=O)CH2CH2OH, -C(=O)-azetidinyl-NHCH3 or -C(=O)-pyrrolidinyl(methyl)-C(=O)OCH3; Preferably, Rj 42 C 1-4 Alkyl, halogenated C 1-4 Alkyl, -NHC 1-4 Alkyl, -N(C 1-4 Alkyl)2, -C(O)C 1-4 Alkyl or -C(O)OC 1-4 alkyl, Preferably, Rj 42 is methyl, ethyl, halomethyl, haloethyl, -NHCH3, -N(CH3)2, -C(O)CH3 or -C(O)OCH3, Preferably, Rj 4 for Preferably, Rj 4 for Among them, the * end is connected to other segments in D; Preferably, R 11 is indolyl, quinolyl or triazolopyridinyl, said indolyl, quinolyl or triazolopyridinyl being optionally substituted by 1, 2, 3, 4 or 5 Rj 41 Substitution, the Rj 41 As defined in this claim; Preferably, R 11 for *end is connected to other segments in D; When L0 is connected to Y3, any hydrogen atom on Y3 is replaced by L0, or any N atom on Y3 is quaternized, and Y3 is as defined in any one of claims 2 to 16 or as defined in this claim; When L0 is connected to Y3, preferably, Y3 is in, The end is connected to L0, and the * end is connected to other fragments in D; Rj 3 is hydrogen or C 1-6 alkyl, Preferably, Rj 3 is hydrogen or C 1-4 alkyl, Preferably, Rj 3 is hydrogen, methyl or ethyl.

18. The antibody-drug conjugate according to any one of claims 1 to 17, wherein: A compound represented by any one of formula (AIII-1) to formula (AIII-10) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where, Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Yj4, Lj are as defined in any one of claims 1 to 17, The end is connected to L0; Preferably, the structural unit Select from the following groups: Preferably, 1) Yj4 is Rj 7 、Rj 71 、Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Lj are as defined in any one of claims 1 to 17 or this claim, and the * end is connected to other fragments in D, Preferably, Yj4 is More preferably, Yj4 is Further preferably, Yj4 is Still further preferably, Yj4 is Among them, the * end is connected to other segments in D; When L0 is connected to Yj4, preferably, Yj4 is More preferably, Yj4 is Further preferably, Yj4 is Still further preferably, Yj4 is in, The end is connected to L0, and the * end is connected to other fragments in D; Or, 2) Yj4 is Rj 13 、Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Lj are as defined in any one of claims 1 to 17 or this claim, and the * end is connected to the other fragments in D; Preferably, Yj4 is More preferably, Yj4 is Further preferably, Yj4 is Among them, the * end is connected to other segments in D; Preferably, Rj 4 C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more selected from hydroxy, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 Alkylene-OH) is substituted by a substituent, Preferably, Rj 4 is cyclopropyl, cyclobutyl, cyclopentyl or 5- to 8-membered bicyclic heterocyclyl, wherein the cyclopropyl, cyclobutyl, cyclopentyl or 5- to 8-membered bicyclic heterocyclyl is optionally substituted by 1, 2 or 3 substituents selected from hydroxy, methyl, -CH2OH or -C(O)-NH(CH2CH2OH), Preferably, Rj 4 for *end is connected to other segments in D; Preferably, Lj is a 5- or 6-membered heteroaryl group, Preferably, Lj is oxazolyl; Preferably, Rj5 is C 1-4 alkyl, Preferably, Rj5 is ethyl; When L0 and Yj4 or Rj 4 When connected, Yj4 or Rj 4 Any hydrogen atom on the 4 Any nitrogen atom on the 4 As defined in any one of claims 2 to 17 or as defined in this claim; When L0 is connected to Yj4, preferably, Yj4 is The end is connected to L0, and the * end is connected to other fragments in D; When L0 and Rj 4 When connected, preferably, Rj 4 for The end is connected to L0, and the * end is connected to other fragments in D; Alternatively, 3) Yj4 is a 3- to 8-membered monocyclic heterocyclic group, a 7- to 12-membered bicyclic heterocyclic group or a phenyl group, wherein the 3- to 8-membered monocyclic heterocyclic group, the 7- to 12-membered bicyclic heterocyclic group or the phenyl group is optionally substituted by one or more selected from C 1-6 Alkyl, -C 1-4 Alkylene-hydroxy or -C 1-4 Substitutents of alkylene-3 to 8-membered monocyclic heterocyclic group, Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 61 , Y1, Y2, Yj3, Lj are as defined in any one of claims 1 to 17 or this claim; Preferably, Yj4 is as defined in claim 12; Preferably, Rj 4 C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group, the C 3-6 Cycloalkyl or 3 to 8 membered heterocyclic group is optionally substituted by one or more selected from hydroxy, methyl, -C 1-4 Alkylene-OH or -C(O)-NH(C 1-4 Alkylene-OH) is substituted by a substituent, Preferably, Rj 4 is cyclopropyl, cyclobutyl or cyclopentyl, said cyclopropyl, cyclobutyl or cyclopentyl being optionally substituted by 1, 2 or 3 substituents selected from hydroxy, methyl or -CH2OH, Preferably, Rj 4 for *end is connected to other segments in D, When L0 and Yj4, Rj 5 , Lj or Rj 21 When connected, Yj4, Rj 5 , Lj or Rj 21 Any hydrogen atom on the 5 , Lj or Rj 21 Any nitrogen atom on the 5 , Lj, Rj 21 As defined in any one of claims 2 to 17 or as defined in this claim; When L0 is connected to Yj4, preferably, Yj4 is More preferably, Yj4 is in, The end is connected to L0, and the * end is connected to other fragments in D; When L0 and Rj 5 When connected, preferably, Rj 5 for The end is connected to L0, and the * end is connected to other fragments in D; When L0 is connected to Lj, preferably, Lj is The end is connected to L0, and the * end is connected to other fragments in D; When L0 and Rj 21 When connected, preferably, Rj 21 for The end is connected to L0, and the * end is connected to other fragments in D.

19. The antibody-drug conjugate according to any one of claims 1 to 18, wherein: A compound represented by any one of Formula (AIA-1) to Formula (AIA-8) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where, Rj 11 、Rj 12 、Rj 21 、Rj 22 、Y1、Y2、Rj 5 、Rj 4 、Rj 3 、Rj 6 、Rj 61 、Rj 7 、Rj 71 , Lj as defined in any one of claims 1 to 18, The end is connected to L0.

20. The antibody-drug conjugate according to any one of claims 1 to 19, wherein: A compound represented by any one of Formula (AIA-1-1) to Formula (AIA-1-7), Formula (AIA-2-1) to Formula (AIA-2-8), Formula (AIA-3-1) to Formula (AIA-3-5), Formula (AIA-4-1) to Formula (AIA-4-6), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 As defined in any one of claims 1 to 19; Xj2 is S or O; Rj 111 is amino, hydroxy or hydrogen; The end is connected to L0; Preferably, 1) The compound represented by Formula (AIA-1a1-1) to Formula (AIA-1a1-4), Formula (AIA-1b1-1) to Formula (AIA-1b1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where, Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 As defined in any one of claims 1 to 19; Xj2 is S or O; The end is connected to L0; Or, 2) A compound represented by any one of Formula (AIA-2a1-1) to Formula (AIA-2a1-5), Formula (AIA-2b1-1) to Formula (AIA-2b1-3), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where, Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 、Rj 71 As defined in any one of claims 1 to 19; Rj 111 is an amino group or a hydroxy group; The end is connected to L0.

21. The antibody-drug conjugate according to any one of claims 1 to 18, wherein A compound represented by any one of formula (AI-1) to formula (AI-6) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where, Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 , Y1, Y2, Lj are as defined in any one of claims 1 to 18, The end is connected to L0; Preferably, A compound represented by any one of Formula (AI-1-1) to Formula (AI-1-4), Formula (AI-2-1) to Formula (AI-2-4), Formula (AI-3-1) to Formula (AI-3-4), Formula (AI-4-1) to Formula (AI-4-4), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 7 As defined in any one of claims 1 to 18; Xj2 is S or O; Rj 111 is an amino group or a hydroxy group; The end is connected to L0.

22. The antibody-drug conjugate according to any one of claims 1 to 18, wherein: A compound represented by any one of Formula (AIIA-1-1) to Formula (AIIA-1-4) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 13 As defined in any one of claims 1 to 18; Xj2 is S or O; The end is connected to L0; Preferably, A compound represented by any one of Formula (AIIA-1a-1) to Formula (AIIA-1a-4), Formula (AIIA-1b-1) to Formula (AIIA-1b-4), or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Where Rj 3 、Rj 4 、Rj 5 、Rj 6 、Rj 61 、Rj 13 As defined in any one of claims 1 to 18; Xj2 is S or O; The end is connected to L0.

23. The antibody-drug conjugate according to any one of claims 1 to 22, wherein: Selected from the structures shown in Table 8, More preferably, Selected from D10, D11, D166, D168, D169-1, D170, D187, D187-A, D192-A, D192-C, D22, D282-A, D283, D284, D284-A, D7-2 , D285, D285-A, D285-B, D286, D286-A, D286-B, D287, D288, D288-A, D289, D290, D291, D292, D293, D294, D295 , D296, D297, D298, D299, D299-A, D3, D300, D301, D302, D303, D304, D305, D305-A, D306, D307, D308, D309, D3 1. D310, D311, D34, D35-A, D38-1, D4, D45-1, D47, D48, D52, D54, D56, D57-A, D6, D61, D63, D64-1, D67-A, D88, More preferably, Selected from D10, D11, D166, D168, D169-1, D170, D22, D3, D31, D34, D35-A, D38-1, D4, D45-1, D47, D48, D52, D54, D56, D57-A, D6, D61, D63, D64-1, Still more preferably, Selected from D31, D34, D35-A, D38-1, D47, D52, D56, D61, D64-1.

24. The antibody-drug conjugate according to any one of claims 1 to 23, wherein: L0 is a hydrophilic linker or a non-hydrophilic linker, Preferably, Selected from the structure shown in formula (III-1) or formula (III-2): -H2-L 1a -L 1b -L 1c -L 1d -D (III-1) -H2-L 1a -L 1b -L 1d (-L 1c -C(=O)-CH3)-D (III-2) As defined in any one of claims 1 to 23; H2 is the antibody connecting unit, connected to Ab; L 1a is a bond or derivative unit; L 1b is a bond or a hydrophilic derivative unit; L 1c is a bond or amino acid unit; L 1d is a bond or drug-linking unit; The L 1a , L 1b , L 1c , L 1d At least one is not a key; H2, L 1a , L 1b , L 1c , L 1d each independently optionally substituted with a hydrophilic group; Preferably, Selected from the structure shown in formula (III-1); Preferably, the hydrophilic group is a 1- to 300-membered straight or branched heteroalkyl group -R end , wherein the 1-300 membered straight chain or branched heteroalkyl group refers to a 1-300 membered straight chain or branched alkyl group in which 1-100 carbon atoms at any position can be replaced by heteroatoms selected from N, O, and S, and the remaining carbon atoms can be optionally replaced by heteroatoms selected from deuterium, C 1-6 Alkyl, oxo (=O), thio (=S) group substitution, R end is H, deuterium, hydroxyl, carboxyl, amino, ester, amide, alkoxy or substituted amino; Preferably, the hydrophilic group is composed of one or more groups selected from the group consisting of N, NH, N(CH3), O, C(O), NHC(O), N(CH3)C(O), C 1-6 Alkyl, polyethylene glycol, polysarcosine, glucose, glucuronic acid, Preferably, the hydrophilic group is selected from: Polysarcosine, Among them, G0 is C 0-8 Hydrocarbon, C 0-8 Heteroalkyl, -NH-, O, S; Preferably, G0 is C 0-8 Hydrocarbon, C 0-8 heteroalkyl, Preferably, G0 is a bond, C 1-4 Alkyl, C 1-4 heteroalkyl, Preferably, G0 is a bond, n-butyl; Preferably, the hydrophilic group is selected from:

25. The antibody-drug conjugate according to any one of claims 1 to 24, wherein: H2 is selected from the group consisting of: in, *end is connected to the antibody, End and L 1a connected; X is -O-(CH2) 0-6 -, -N(CH3)-, -O-, -CONH-, -CON(CH3)-, R x1 、R x2 are independently hydrogen, C 1-6 Alkyl, halogen, deuterated, C 1-6 Alkoxy, C 1-6 Alkylene-NH-, (C 1-6 Alkyl) 2-N-, R 31 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, R 32 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, Cy2 is a 5-10 membered heteroaryl group, C 6-10 Aryl, 3-10 membered heterocyclic group, C 3-10 Cycloalkyl, The side chain is a hydrophilic group, and the hydrophilic group is as defined in claim 24; Preferably, R x1 、R x2 are independently hydrogen, C 1-4 Alkyl, halogen, deuterated, C 1-4 Alkoxy, C 1-4 Alkylene-NH-, (C 1-4 Alkyl) 2-N-, Preferably, R x1 、R x2 Each is independently hydrogen, methyl, halogen, deuterated, methoxy, methyl-NH-, (methyl)2-N-; Preferably, R 31 is hydrogen, deuterium, halogen, cyano, methyl, Preferably, R 31 is hydrogen; Preferably, R 32 is hydrogen, deuterium, halogen, cyano, methyl, Preferably, R 32 is hydrogen; Preferably, Cy2 is a 5-10 membered heteroaryl, C 6-10 Aryl, 4-8 membered heterocyclic group, C 3-6 Cycloalkyl, Preferably, Cy2 is pyrrolyl, imidazolyl, pyridyl, pyrimidinyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, cyclopropyl, cyclobutyl, or cyclopentyl; Preferably, H2 is selected from the group consisting of: Still more preferably, H2 is Among them, the * end is connected to the antibody, End and L 1a connected.

26. The antibody-drug conjugate according to any one of claims 1 to 25, wherein: L 1a is a bond, or is selected from C 1-6 Alkyl, C 1-6 Alkylene-C(=O), C 1-6 Alkylene-C(=O)NH, C 1-6 Heteroalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-8 Cycloalkyl, 4-10 membered heterocyclic group, C 6-10 Aryl, 5-10 membered heteroaryl, C 1-4 Alkylene-C 3-8 Cycloalkyl, C 1-4 Alkylene-4-10 membered heterocyclic group, C 1-4 Alkylene-C 6-10 Aryl, C 1-4 Alkylene-5-10 membered heteroaryl, C 1-6 Heteroalkylene-C(=O), C 2-6 Alkenylene-C(=O), C 2- 6Alkynylidene-C(=O), C 3-8 Cycloalkyl-C(=O), 4-10 membered heterocyclyl-C(=O), C 6-10 Aryl-C(=O), 5-10 membered heteroaryl-C(=O), C 1-4 Alkylene-C 3-8 Cycloalkyl-C(=O), C 1-4 Alkylene-4-10 membered heterocyclyl-C(=O), C 1-4 Alkylene-C 6-10 Aryl-C(=O), C 1-4 Alkylene-5-10 membered heteroaryl-C(=O), C 1-6 Heteroalkylene-C(=O)NH, C 2-6 Alkenylene-C(=O)NH, C 2- 6 alkynylene-C(=O)NH, C 3-8 Cycloalkyl-C(=O)NH, 4-10 membered heterocyclyl-C(=O)NH, C 6-10 Aryl-C(=O)NH, 5-10 membered heteroaryl-C(=O)NH, C 1-4 Alkylene-C 3-8 Cycloalkyl-C(=O)NH, C 1-4 Alkylene-4-10 membered heterocyclic group-C(=O)NH, C 1-4 Alkylene-C 6-10 Aryl-C(=O)NH, C 1-4 Alkylene-5-10 membered heteroaryl-C(=O)NH, the C 1-6 Alkyl, C 1-6 Alkylene, C 1-4 The alkylene group is optionally replaced by -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NH-C 1-4 Alkylene-COOH substituted, the L 1a Optionally substituted with a hydrophilic group, the hydrophilic group being as defined in claim 24; Preferably, L 1a is a bond, phenyl, described The left side is connected to H2 and the right side is connected to L 1b further preferably, L 1a For a key.

27. The antibody-drug conjugate according to any one of claims 1 to 26, wherein: L 1b is a bond, or is selected from: The left side of the above fragment is connected to L 1a Connected to the right side with L 1c connected, G is C 0-8 Hydrocarbylene, C 0-8 Heteroalkylene, -O-, -NH- or a bond, G1 and G2 are each independently C 0-8 Hydrocarbylene, C 0-8 Heteroalkylene, -O-, -NH- or a bond, R 33 is a 3-12 membered heterocyclic ring, a 5-10 membered heteroaromatic ring, NR 34 、-CONR 34 -、-NR 34 CO-, R 34 is hydrogen, -(CH2CH2O) 0-12 -H, -(CH2CH2O) 0-12 -CH3, -CO-(CH2CH2O) 0-12 -H, -CO-(CH2CH2O) 0- 12 -CH3、CH2-CO-(N(Me)-CH2-CO) 0-24 -OH, Het is a 5-6 membered heteroaromatic ring, The side chain is a hydrophilic group, and the hydrophilic group is as defined in claim 24; Preferably, G is C 1-6 Alkylene, C 2-6 Alkenylene, C 2-6 Alkynylidene, C 1-6 Heteroalkylene, -O-, -NH- or a bond, Preferably, G is methylene, ethylene, n-propylene, -N-CH2-, -O-, -NH- or a bond; Preferably, G1 and G2 are each independently C 1-4 Alkylene, C 2-6 Alkynylidene, -NHC 1-4 Alkylene, -O-, -NH- or a bond, Preferably, G1 and G2 are each independently methylene, ethylene, n-propylene, -O-, -NH- or a bond, Preferably, G1 is a methylene group, Preferably, G2 is ethylene; Preferably, R 33 is a 5-10 membered heteroaromatic ring, Preferably, R 33 is a 5-6 membered heteroaromatic ring, Preferably, R 33 is pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, Preferably, R 33 is 1,2,3-triazolyl; Preferably, L 1b is a bond or is selected from: Preferably, L 1b for More preferably, L 1b is a bond or is selected from: The left side of the above fragment is connected to L 1a Connected to the right side with L 1c connected.

28. The antibody-drug conjugate according to any one of claims 1 to 27, wherein L 1c is a bond, or an amino acid unit, wherein the amino acid unit is an amino acid residue or a short peptide consisting of 2-10 amino acid residues, wherein the amino acid residue is optionally substituted by a hydrophilic group or a C 1-6 Alkyl substituted, the hydrophilic group is as defined in claim 24, the amino acid residue is selected from a natural amino acid residue, a non-natural amino acid residue or an amino acid residue represented by formula (1a) or a stereoisomer thereof, in, R 35 , R 36 Each independently selected from: hydrogen, deuterium, And R 35 , R 36 Not H at the same time, or R 35 , R 36 Together with the carbon atoms to which they are commonly connected, they form a 3-8 membered cycloalkyl or a 4-10 membered heterocyclic group, wherein the 3-8 membered cycloalkyl or the 4-10 membered heterocyclic group is optionally substituted by one or more R 40 replace; r, r1 are each independently an integer from 0 to 20; R 37 , R 38 Each independently is H, C 1-6 Alkyl, C 3-6 Cycloalkyl or -COO-C 1-6 Alkyl, or R 37 , R 38 Together with the nitrogen atom to which it is attached, it forms a 4-10 membered heterocyclic group, wherein the 4-10 membered heterocyclic group is optionally substituted by one or more R 40 replace; R 39 C 1-6 alkyl; R 40 C 1-6 Alkyl, C 1-6 Halogenated alkyl, C 1-6 Heteroalkyl, C 3-6 Cycloalkyl, 4-10 membered heterocyclic group, C 1-6 Alkylene-C 3-6 Cycloalkyl, C 1-6 Alkylene-4-10 membered heterocyclic group, -NR 401 R 402 and optionally C 1-6 Alkyl-substituted 4-10 membered heterocyclic group, R 401 、R 402 Each independently is H or C 1-6 alkyl; Preferably, r, r1 are each independently 0, 1, 2, 3, 4 or 5, Preferably, r is 0, Preferably, r1 is 4; Preferably, R 37 , R 38 Each independently is H, C 1-4 Alkyl, C 3-6 Cycloalkyl or -COO-C 1-4 alkyl, Preferably, R 37 , R 38 Each independently is H or C 1-4 alkyl, Preferably, R 37 , R 38 are each independently ethyl; Preferably, R 39 C 1-4 alkyl, Preferably, R 39 is methyl or ethyl, Preferably, R 40 C 1-4 Alkyl, C 1-4 Halogenated alkyl, C 3-6 Cycloalkyl, C 1-4 Alkylene-C 3-6 Cycloalkyl or -NR 401 R 402 , R 401 、R 402 Each independently is H or C 1-4 alkyl, Preferably, R 40 is methyl, halomethyl, cyclopropyl, amino, NHCH3 or N(CH3)2; Preferably, R 35 , R 36 Each independently selected from: hydrogen, deuterium, The r1, R 37 , R 38 As defined in this claim, Preferably, R 35 For hydrogen, Preferably, R 36 is -(CH2)4N(CH3)2; In formula (III-1), Preferably, L 1c is a bond or is selected from: Preferably, L 1c Selected from: More preferably, L 1c is a bond or is selected from: Preferably, the left side of the above segment is 1c Connected to the right side with L 1d connected; In formula (III-2), Preferably, L 1c is a bond or is selected from: Preferably, the left side of the above fragment is connected to -C(=O)CH3, and the right side is connected to L 1d connected.

29. The antibody-drug conjugate according to any one of claims 1 to 28, wherein In formula (III-1), L 1d For a key, or L 1d Select from the following groups: The benzene ring in the above fragment is optionally substituted by one or more of the following groups: -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NHC 1- 4-alkyl, -C 1-4 Alkylene-N(C 1-4 Alkyl)2, -C 1-4 Alkylene-NH-C 1-4 Alkylene-COOH, In the above fragment, R L1d is hydrogen or C 1-4 alkyl, The side chain in the above segment is a hydrophilic group, and the hydrophilic group is as defined in claim 24, The left side of the above fragment is connected to L 1c Connected to, the right side is connected to D; Preferably, L 1d The benzene ring in the group is optionally substituted by one or more of the following groups: -C 1-4 Alkylene-NHC 1-4 Alkyl, -C 1-4 Alkylene-N(C 1-4 Alkyl)2, Preferably, L 1d The benzene ring in the group is optionally substituted by 1, 2 or 3 of the following groups: -CH2NHCH3, -CH2NH(CH3)2; Preferably, the R L1d is hydrogen, methyl, ethyl or isopropyl, Preferably, the R L1d is methyl; More preferably, L 1d is a bond or is selected from the following group: The left side of the above fragment is connected to L 1c Connected to, the right side is connected to D; In formula (III-2), L 1d For a key, or L 1d Select from the following groups: The benzene ring in the above group is optionally substituted by one or more of the following groups: -C 1-4 Alkylene-NH2, -C 1-4 Alkylene-NHC 1- 4-alkyl, -C 1-4 Alkylene-N(C 1-4 Alkyl)2, -C 1-4 Alkylene-NH-C 1-4 Alkylene-COOH; Above the above fragment and L 1b Connected to the left with L 1c Connected to, the right side is connected to D; Preferably, L 1d for 30. The antibody-drug conjugate according to any one of claims 1 to 29, wherein 1)-H2-L 1a -L 1b -L 1c -L 1d - selected from the structures shown in Table 9, More preferably, the -H2-L 1a -L 1b -L 1c -L 1d -Selected from L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, L12, L13, L14, L15, L16, L17, L19, L22, L23, L24, L2 5. L26, L34, L52, L53, L54, L54-2, L57, L58, L63, L64, L65, L66, L67, L68, L69, L70, L72, L73, L74, Further preferably, the -H2-L 1a -L 1b -L 1c -L 1d - is selected from L1, L2, L4, L5, L6, L7, L8, L9, L10, L11, L12, L13, L14, L15, L16, L17, L23, L24, L25, Still more preferably, the -H2-L 1a -L 1b -L 1c -L 1d - selected from L1, L4, L5, L6, L7, L10, L12, L13, L14, L15, L16, L23; 2)-H2-L 1a -L 1b -L 1d (-L 1c -C(=O)-CH3)- is selected from the structures shown in Table 10.

31. The antibody-drug conjugate according to any one of claims 1 to 30, wherein the structure of the antibody-drug conjugate represented by formula (I) is represented by formula (IV-1) or formula (IV-2): in, Ab、n、H2、L 1a , L 1b , L 1c , L 1d , D as defined in any one of claims 1-30; Preferably, the structure of the antibody-drug conjugate represented by formula (I) is as shown in formula (IV-1).

32. The antibody-drug conjugate according to any one of claims 1 to 31, wherein: Ab is an antibody or antigen-binding fragment thereof that binds to one, two or more targets selected from the group consisting of HER2, Trop2, EGFR, Claudin18.2, Nectin-4, FRα, TF, CD49B, Claudin7, HER3, Notch1, MUC5AC, IGF1R, cMET, PD-L1, B7-H3, B7-H4, CDCP1, MUC16, MUC1, MSLN, FAP, 5T4, CEACAM5, LIV, NaPi2b, AXL, LY6E, CDH6, CDH17, ITGB6, Claudin6, CEACAM6, LY6G6D, LGR5, PTK7, CD228, and SLC34A2; Preferably, the Ab is selected from the group consisting of an anti-EGFR antibody or an antigen-binding fragment thereof, an anti-HER3 antibody or an antigen-binding fragment thereof, a bispecific antibody or an antigen-binding fragment thereof that specifically binds to EGFR and HER3; Preferably, the anti-EGFR antibody or antigen-binding fragment thereof is Panitumumab, Necitumumab, Nimotuzumab, EG-007, Laprituximab, Cetuximab or JMT101; Preferably, the anti-HER3 antibody or antigen-binding fragment thereof is Seribantumab, Elgemtumab, Lumretuzumab, AV203, Barecetamab, CDX-3379, GSK2849330, HMBD-001, REGN1400, or Patritumab; Preferably, the bispecific antibody or antigen-binding fragment thereof that specifically binds to EGFR and HER3 is SI-B001 or Duligotuzumab; Preferably, the Ab is linked to L0 or H2 via its sulfhydryl group.

33. The antibody-drug conjugate according to any one of claims 1 to 32, wherein: n is a number from 1 to 15, Preferably, n is a number between 2 and 10, Preferably, n is a number from 3 to 9, such as 3 to 4.5, 4.5 to 6, 6 to 7, 7 to 8, 8 to 9, such as about 3.1, about 3.2, about 3.3, about 3.4, about 3.5, about 3.6, about 3.7, about 3.8, about 3.9, about 4, about 4.1, about 4.2, about 4.3, about 4.4, about 4.5, about 4.6, about 4.7, about 4.8, about 4.9, about 5, about 5.1, about 5.2, about 5.3, about 5.4, about 5.5, about 5.6, about 5.7, about 5.8, about 5.9, about 6. 6, about 5.7, about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9, about 8, about 8.1, about 8.2, about 8.3, about 8.4, about 8.5, about 8.6, about 8.7, about 8.8, about 8.9, about 9.

34. The antibody-drug conjugate according to any one of claims 1 to 33, wherein: The antibody-drug conjugate is as follows: As shown in the following formula (V-4) or formula (V-4-A): in, H2, L 1a , L 1b , L 1c , L 1d 、Rj 5 、Rj 11 、Rj 12 、Rj 21 、Rj 22 、Rj 3 、R 4a , Lj, Yj4, Y1, Y2, Y3, n, Ab are as defined in any one of claims 1-33.

35. The antibody-drug conjugate according to any one of claims 1 to 34, wherein The antibody-drug conjugate is selected from the structures shown in Table 11.

36. A pharmaceutical composition comprising the antibody-drug conjugate according to any one of claims 1 to 35; and a pharmaceutically acceptable carrier.

37. Use of the antibody-drug conjugate according to any one of claims 1 to 35 or the pharmaceutical composition according to claim 36 in the preparation of a medicament for preventing and / or treating a disease or condition associated with RAS protein activity; Preferably, the disease or disorder associated with RAS protein activity is cancer; Preferably, the cancer is pancreatic cancer, colorectal cancer, non-small cell lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, melanoma, bladder cancer or head and neck cancer.

38. The compound represented by formula (VII), L0-D (VII) in, D as defined in any one of claims 1 to 23; L0 includes H1, L 1a , L 1b , L 1c , L 1d , the L 1a , L 1b , L 1c , L 1d As defined in any one of claims 24 to 31 righteous; H1 is the antibody connecting unit, Preferably, H1 is selected from the group consisting of: in, X is -O-(CH2) 0-6 -, -N(CH3)-, -O-, -CONH-, -CON(CH3)-, R x1 、R x2 are independently hydrogen, C 1-6 Alkyl, halogen, deuterated, C 1-6 Alkoxy, C 1-6 Alkylene-NH-, (C 1-6 Alkyl) 2-N-, R 31 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, R 32 For hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, Cy2 is a 5-10 membered heteroaryl group, C 6-10 Aryl, 3-10 membered heterocyclic group, C 3-10 Cycloalkyl, The side chain is a hydrophilic group, and the hydrophilic group is as defined in claim 24; Preferably, R x1 、R x2 are independently hydrogen, C 1-4 Alkyl, halogen, deuterated, C 1-4 Alkoxy, C 1-4 Alkylene-NH-, (C 1-4 Alkyl) 2-N-, Preferably, R x1 、R x2 Each is independently hydrogen, methyl, halogen, deuterated, methoxy, methyl-NH-, (methyl)2-N-; Preferably, R 31 is hydrogen, deuterium, halogen, cyano, methyl, Preferably, R 31 is hydrogen; Preferably, R 32 is hydrogen, deuterium, halogen, cyano, methyl, Preferably, R 32 is hydrogen; Preferably, Cy2 is a 5-10 membered heteroaryl, C 6-10 Aryl, 4-8 membered heterocyclic group, C 3-6 Cycloalkyl, Preferably, Cy2 is pyrrolyl, imidazolyl, pyridyl, pyrimidinyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, cyclopropyl, cyclobutyl, or cyclopentyl; Preferably, H1 is selected from the group consisting of: More preferably, H1 is selected from the following group: Further preferably, H1 is selected from the following group: Still more preferably, H1 is Preferably, L0-D is selected from the structure shown in formula (VII-A) or formula (VII-B): H1-L 1a -L 1b -L 1c -L 1d -D (VII-A) H1-L 1a -L 1b -L 1d (-L 1c -C(=O)-CH3)-D (VII-B) The L 1a , L 1b , L 1c , L 1d , D is as defined in any one of claims 1-31, and H1 is as defined in this claim.

39. The compound of claim 38, wherein L0-D is selected from the structures shown in Table 12.

40. Use of the compound according to claim 38 or 39 in the preparation of the antibody-drug conjugate according to any one of claims 1 to 35.

41. A compound represented by formula (Z-III) or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: Where, R m1 is hydrogen; R m2 is hydrogen; R m3 is hydrogen; R m4 is hydrogen, halogen or C 1-6 Alkyl; R m5 is hydrogen, halogen or C 1-6 alkyl; and is a single bond; or R m1 and R m3 All are none; R m2 is hydrogen; R m4 is hydrogen, halogen or C 1-6 Alkyl; R m5 is hydrogen, halogen or C 1-6 alkyl; and is a double bond; or R m1 With R m2 Connected together to form -CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;R m3 is hydrogen; R m4 is hydrogen, halogen or C 1-6 Alkyl; R m5 is hydrogen, halogen or C 1-6 Alkyl; R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl; and is a single bond; or R m1 With R m3 Connected together to form -CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;R m2 is hydrogen; R m4 is hydrogen, halogen or C 1-6 Alkyl; R m5 is hydrogen, halogen or C 1-6 Alkyl; R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl; and is a single bond; or R m1 With R m4 Connected together to form -CR m7 R m6 -or-CR m7 R m6 -CR m9 R m8 -;R m2 is hydrogen; R m3 is hydrogen; R m5 is hydrogen, halogen or C 1-6 Alkyl; R m6 、R m7 、R m8 、R m9 are each independently hydrogen, halogen or C 1-6 alkyl; and is a single bond; R 11 、R 12 are independently hydrogen, deuterated C 1-6 Alkyl or C 1-6 alkyl; Y1 is N or CH; wherein N can be oxidized (N + -O - ); Y2 is N or CH; wherein N can be oxidized (N + -O - ); R 3 is hydrogen or C 1-6 alkyl; Yj3 is NH-R 6 , OR 6 、-C 1-4 Alkylene-NH-R 6 、-C 1-4 Alkylene-OR 6 ; R 6 is hydrogen or C 1-6 alkyl; R 61 C 1-6 alkyl; R 21 、R 22 、R 5 , L, R 4 、Y4 is as described in case (1), (2), (3), (4) or (5): Situation (1) R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; L is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 The aryl group is optionally substituted with a hydroxy or amino group; R 5 For hydrogen, ethyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; R 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl or -CR a R b -NR c R d , the C 6-10 Aryl, heteroaryl, C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 SF5, P(=O)(C 1-6 alkyl)2, methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is in, R 7 for R 8 is O or NH; X1 is -CR 91 R 92 -or-NR 10 -; R 71 For hydrogen, C 1-6 Alkyl or -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH-R 6 ; R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; R 91 、R 92 are not hydrogen at the same time; and -C 1-4 Alkylene - optionally substituted with methyl; R 10 is hydrogen, -C(O)-C 1-4 Alkylene-NR f R g or -C(O)-C 1-4 Alkylene-OH; m is 1 or 2; R a 、R b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl; R c 、R d are independently hydrogen, -C(O)H, C 1-6 Alkyl, halogenated C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 wherein the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; When R m1 is hydrogen; R m2 is hydrogen; R m3 is hydrogen; R m4 is hydrogen; R m5 is hydrogen; is a single bond; R 4 for R 3 、R 21 、R 22 is hydrogen, L is thiazolyl, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 When it is hydrogen, and R 5 When it is ethyl, R 7 Not for When R m1 is hydrogen; R m2 is hydrogen; R m3 is hydrogen; R m4 is hydrogen; R m5 is hydrogen; is a single bond; R 4 for R 3 、R 21 、R 22 is hydrogen, L is thiazolyl, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 When it is hydrogen, and R 5 When it is ethyl, R 7 Not for When R m1 is hydrogen; R m2 is hydrogen; R m3 is hydrogen; R m4 is hydrogen; R m5 is hydrogen; is a single bond; R 4 for R 3 、R 21 、R 22 is hydrogen, L is thiazolyl, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 When it is hydrogen, and R 5 When it is -CH2CH2OH or -CH2CH2NH(CH3), R 7 Not for or Case (2) R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; L is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 The aryl group is optionally substituted with a hydroxy or amino group; R 5 For hydrogen, ethyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; R 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl or 5 to 8 membered heterocyclic group, the C 6-10 Aryl, heteroaryl, C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is Among them, R 13 As in case (21) or (22): Case (21) R 13 for Among them, X1 is -CR 91 R 92 -;R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; R 91 、R 92 are not hydrogen at the same time; m is 1 or 2; and Y1 is N + -O - ; Y2 is CH; or Y1 is CH; Y2 is N + -O - ; or Case (22) R 13 is an oxo 5-membered heterocyclic group-L1-L2-R 14 , 6-membered heterocyclic group-L1-L2-R 14 or oxo 7-membered heterocyclic group-L1-L2-R 14 ; L1 is -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-; L2 is -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-; R 14 C 1-6 heteroalkyl; R c 、R d are independently hydrogen, -C(O)H, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1- wherein the 5- to 8-membered heterocyclic group is optionally replaced by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; Case (3) R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; L is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 The aryl group is optionally substituted with a hydroxy or amino group; R 5 For hydrogen, C 1-6 Alkyl (such as ethyl), C 3-6 Cycloalkyl (e.g., cyclopropyl), -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; R 4 is a 5- to 8-membered heterocyclic group; Y4 is in, R 7 for R 8 is O or NH; X1 is -CR 91 R 92 -or-NR 10 -; R 71 For hydrogen, C 1-6 Alkyl or -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH-R 6 ; R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; R 91 、R 92 Not simultaneously hydrogen; R 10 For hydrogen, C 1-6 Alkyl, -C(O)-C 1-4 Alkylene-NR f R g or -C(O)-C 1-4 Alkylene-OH; m is 1 or 2; R a 、R b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl; R c 、R d are independently hydrogen, -C(O)H, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1- wherein the 5- to 8-membered heterocyclic group is optionally replaced by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; Case (4) R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; and R 21 、R 22 Not simultaneously hydrogen; L is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 The aryl group is optionally substituted with a hydroxy or amino group; R 5 For hydrogen, C 1-6 Alkyl (such as ethyl), C 3-6 Cycloalkyl (e.g., cyclopropyl), -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; R 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl or -CR a R b -NR c R d , the C 6-10 Aryl, heteroaryl, C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is in, R 7 for X1 is -NR 10 -; R 71 For hydrogen, C 1-6 Alkyl or -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH-R 6 ; R 10 C 1-6 alkyl; m is 1 or 2; R a 、R b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl; R c 、R d are independently hydrogen, -C(O)H, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1- wherein the 5- to 8-membered heterocyclic group is optionally replaced by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; Case (5) R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; L is oxazole; R 5 For hydrogen, C 1-6 Alkyl (such as ethyl), C 3-6 Cycloalkyl (e.g., cyclopropyl), -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; R 4 C 6-10 Aryl, heteroaryl, C 3-6 Cycloalkyl, 5- to 8-membered heterocyclic group or -CR a R b -NR c R d , the C 6-10 Aryl, heteroaryl, C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is in, R 7 for R 7 Can optionally be replaced by -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-R 6 replace; R 8 is O or NH; X1 is -O-, -CR 91 R 92 -or-NR 10 -; R 71 For hydrogen, C 1-6 Alkyl or -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NH-R 6 ; R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; and -C 1-4 Alkylene - may be substituted with methyl; R 10 For hydrogen, C 1-6 Alkyl, -C(O)-C 1-4 Alkylene-NR f R g or -C(O)-C 1-4 Alkylene-OH; m is 0, 1, or 2; n is 0, 1, or 2; R a 、R b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl; R c 、R d are independently hydrogen, -C(O)H, C 1-6 Alkyl, phenyl, pyridyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 wherein the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; R f is hydrogen or C 1-6 alkyl; R g is hydrogen or C 1-6 alkyl.

42. The compound of claim 41 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: In case (1), When R 4 for When R 7 Not for When R m1 is hydrogen; R m2 is hydrogen; R m3 is hydrogen; R m4 is hydrogen; R m5 is hydrogen; is a single bond; R 4 is a heteroaryl group, wherein the heteroaryl group is optionally substituted by one or more selected from R 41 Substituents substituted, R 41 SF5, P(=O)(C 1-6 alkyl)2, methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d When R 7 Not for 43. The compound of claim 41 or 42, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof: wherein The compound is selected from the compound represented by formula (Z-IIIA): Where, R 11 、R 12 are independently hydrogen, deuterated C 1-6 Alkyl or C 1-6 alkyl; R 21 、R 22 are each independently hydrogen, -NR f R g 、-OC 1-4 Alkylene-NR f R g or C 1-6 alkyl; Y1 is N or CH; wherein N can be oxidized (N + -O - ); Y2 is N or CH; wherein N can be oxidized (N + -O - ); L is C 6-10 Aryl or 5 or 6 membered monocyclic heteroaryl, said C 6-10 The aryl group is optionally substituted with a hydroxy or amino group; R 3 is hydrogen or C 1-6 alkyl; R 5 For hydrogen, ethyl, -C 1-4 Alkylene-OH, -C 1-4 Alkylene-NHR e or -C 1-4 Alkylene-C 1-6 alkoxy; Yj3 is NH-R 6 , OR 6 、-C 1-4 Alkylene-NH-R 6 、-C 1-4 Alkylene-OR 6 ; R 6 is hydrogen or C 1-6 alkyl; R 61 C 1-6 alkyl; R 4 、Y4 is as described in case (1) or (2): Case (1) R 4 C 3-6 Cycloalkyl, 5- to 8-membered heterocyclic group or -CR a R b -NR c R d , the C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is in, R 7 for R 8 is O or NH; X1 is -CR 91 R 92 -or-NR 10 -; R 71 For hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene -OH or -C 1-4 Alkylene-NH-R 6 ; R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; R 91 、R 92 Not simultaneously hydrogen; R 10 is hydrogen, -C(O)-C 1-4 Alkylene-NR f R g or -C(O)-C 1-4 Alkylene-OH; m is 1 or 2; R a 、R b are independently hydrogen, C 1-6 Alkyl or C 3-6 Cycloalkyl; R c 、R d are independently hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 wherein the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; R f is hydrogen or C 1-6 alkyl; R g is hydrogen or C 1-6 alkyl; When R 4 for R 3 、R 21 、R 22 is hydrogen, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 is hydrogen, R 5 When it is ethyl, R 7 Not for When R 4 for R 3 、R 21 、R 22 is hydrogen, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 is hydrogen, R 5 When it is -CH2CH2OH or -CH2CH2NH(CH3), R 7 Not for or Case (2) R 4 C 3-6 Cycloalkyl or 5 to 8 membered heterocyclic group, the C 3-6 The cycloalkyl group is optionally substituted with one or more selected from R 41 Substituents substituted; R 41 Methyl, -C 1-4 Alkylene-OH or -C(O)-NR c R d ; Y4 is Among them, R 13 As in case (21) or (22): Case (21) R 13 for Among them, X1 is -CR 91 R 92 -;R 91 、R 92 are independently hydrogen, hydroxy, cyano, -NR c R d 、-C 1-4 Alkylene-NR c R d 、-C 1-4 Alkylene-OH or -C(O)-NR c R d ; R 91 、R 92 are not hydrogen at the same time; m is 1 or 2; and Y1 is N + -O - ; Y2 is CH; or Y1 is CH; Y2 is N + -O - ; or Case (22) R 13 is an oxo 5-membered heterocyclic group-L1-L2-R 14 , 6-membered heterocyclic group-L1-L2-R 14 or oxo 7-membered heterocyclic group-L1-L2-R 14 ; L1 is -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-; L2 is -C 1-4 Alkylene-O- or -C 1-4 Alkylene-NH-; R 14 C 1-6 heteroalkyl; R c 、R d are independently hydrogen, C 1-6 Alkyl, -C 1-4 Alkylene-OH, -C(O)-5 to 8 membered heterocyclic group or -C(O)-C 1-4 wherein the 5 to 8 membered heterocyclic group is optionally substituted by one or more selected from R 42 Substituents substituted; R 42 Methyl, -NR f R g 、-C(O)R e or-C(O)OR e ; R e C 1-6 alkyl; R f is hydrogen or C 1-6 alkyl; R g is hydrogen or C 1-6 alkyl.

44. The compound of claim 43 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: In case (1): When R 4 for R 3 、R 21 、R 22 is hydrogen, Yj3 is OR 6 , Y1 is N, Y2 is CH, R 11 、R 12 、R 6 、R 61 is methyl, R 71 is hydrogen, R 5 When it is ethyl, R 7 Not for When R 4 for When R 7 Not for 45. The compound of any one of claims 41 to 44, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: Y1 is N or N + -O - ; Y2 is CH; Still more preferably, Y1 is N; Y2 is CH.

46. ​​The compound of any one of claims 41 to 45, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: R 11 is methyl or deuterated methyl; R 12 is methyl or deuterated methyl; More preferably, R 11 is methyl; R 12 It is a methyl group.

47. The compound of any one of claims 41 to 46, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: R 21 、R 22 are independently hydrogen, -OC 1-4 Alkylene-NR f R g , R f C 1-6 Alkyl, R g C 1-6 alkyl; Preferably, R 21 is hydrogen; R 22 is hydrogen, -NH2, -OCH2CH2N(CH3)2, -OCH2CH2NH(CH3); further preferably, R 21 is hydrogen; R 22 For hydrogen.

48. A compound according to any one of claims 41 to 47, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein L is phenyl, thiazolyl, oxazolyl, 1,3,4-oxadiazole or 1,2,4-oxadiazole, wherein the phenyl group is optionally substituted with a hydroxyl group or an amino group; Preferably, L is phenyl, thienyl or oxazolyl, wherein the phenyl group is optionally substituted with a hydroxyl group or an amino group; Still more preferably, L is thienyl or oxazolyl.

49. The compound of any one of claims 41 to 48, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: The compound is represented by formula (Z-IA-1), formula (Z-IA-2), formula (Z-IA-3) or formula (Z-IA-4): Where R 3 、R 4 、R 5 、R 6 、R 61 、R 7 、R 71 Each is defined as described in any one of claims 41-48; X2 is S or O; R 111 is amino, hydroxy or hydrogen.

50. The compound of any one of claims 41 to 49, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: Select from the following groups: Preferably, Select from the following groups:

51. The compound of any one of claims 41 to 50, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: R 5 is ethyl, cyclopropyl, -(CH2)2OH, -(CH2)3OH, -(CH2)2-NH(CH3) or -(CH2)2-OCH3; Preferably, R 5 is ethyl, -(CH2)2OH, -(CH2)3OH, -(CH2)2-NH(CH3) or -(CH2)2-OCH3; More preferably, R 5 Ethyl, -(CH2)3OH or -(CH2)2-OCH3; Still more preferably, R 5 For ethyl.

52. The compound of any one of claims 41 to 51, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: R 6 is hydrogen; or R 6 Methyl, R 61 It is a methyl group.

53. The compound of any one of claims 41-52, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: R 71 is hydrogen or -C 1-4 Alkylene-OH, More preferably, R 71 is hydrogen or -CH2OH, Still more preferably, R 71 is hydrogen; R 7 Select from the following groups: Preferably, R 7 Select from the following groups: R 71 is hydrogen or -CH2OH; Preferably, R 7 Select from the following groups: R 71 is hydrogen or -CH2OH; Still more preferably, R 71 is hydrogen, R 7 Selected from Where m is 1 and X1 is -CR 91 R 92 -, R 91 is cyano, R 92 Definition as described in any one of claims 41-52; preferably R 92 is hydrogen, -NR c R d 、-C 1-4 Alkylene-NR c R d or -C 1-4 Alkylene-OH, R c 、R d are independently hydrogen, C 1-6 Alkyl; preferably R 92 is hydrogen, -NH2, -CH2NH2, -CH2NH(CH3), -CH2OH or -C(O)-NH(CH2CH2OH); Still more preferably, R 71 is hydrogen, R 7 Select from the following groups: Still more preferably, R 71 is hydrogen, R 7 Select from the following groups:

54. The compound of claim 41-53 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: The compound is selected from Table A-1 or Table A-2.

55. The compound of any one of claims 41 to 48, or a stable deuterated derivative thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein: The compound is represented by formula (Z-IIA-1) or formula (Z-IIA-2): Where R 3 、R 4 、R 5 、R 6 、R 61 、R 13 Each is defined as described in any one of claims 41-48; X2 is S or O.

56. The compound of claim 55 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein Select from the following groups: More preferably, Select from the following groups:

57. The compound of claim 55 or 56, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R 13 Select from the following groups:

58. The compound of any one of claims 55 to 57, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein: The compound is selected from Table B-1 or Table B-2.

59. A pharmaceutical composition comprising the compound of any one of claims 41 to 58 or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof; and a pharmaceutically acceptable carrier.

60. Use of the compound according to any one of claims 41 to 58, or a stable deuterated derivative or stereoisomer thereof, or a pharmaceutically acceptable salt, solvate or prodrug thereof, or the pharmaceutical composition according to claim 59, in the preparation of a medicament for preventing and / or treating a disease or condition associated with RAS protein activity; Preferably, the disease or disorder associated with RAS protein activity is cancer; Preferably, the cancer is pancreatic cancer, colorectal cancer, lung cancer, acute myeloid leukemia, multiple myeloma, thyroid adenocarcinoma, myelodysplastic syndrome, squamous cell lung cancer, esophageal cancer, ovarian cancer, uterine cancer, melanoma, bladder cancer or head and neck cancer; Preferably, the lung cancer is non-small cell lung cancer.

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