Medicinal liquor for treating traumatic injury and osteomyelitis

Abstract

The invention provides medicinal liquor for treating traumatic osteoporosis and relates to the technical field of medicinal liquor. The medicinal liquor is prepared from the following raw medicinal materials in parts by weight: 40-60 parts of premna fulva; 20-40 parts of asarum sieboldii miq; 10 to 20 parts of anisodus acutangulatus; 30-50 parts of lamiophlomis rotata; 15 to 30 parts of radix aconiti preparata; 15-30 parts of prepared kusnezoff monkshood root 20 to 40 parts of alangium platanifolium flower; 15-25 parts of pericarpium zanthoxyli; 20 to 40 parts of snake bone; 10 to 20 parts of radix aconiti lateralis preparata; 20-40 parts of pseudo-ginseng; 15 to 25 parts of ground beetles; 25-35 parts of radix achyranthis bidentatae; 10 to 15 parts of licorice root; the traditional Chinese medicine composition has the advantages that ethnic medicinal materials such as premna fulva and snake bone are combined with medicinal materials capable of promoting blood circulation to arrest pain, specific toxic medicinal materials are processed and matched, toxicity reducing and efficacy enhancing effects are achieved, and the traditional Chinese medicine composition has bone drilling and ventilating permeability especially for arthralgia and myalgia and joint disadvantage caused by traumatic injuries and wind-cold-dampness arthralgia.

Description

Technical Field

[0001] This invention relates to the field of medicinal wine technology, and in particular to a medicinal wine for treating injuries and bone-strengthening conditions. Background Technology

[0002] Traumatic injuries and rheumatic pain are common and frequently occurring diseases in clinical practice. Traditional Chinese medicine believes that traumatic injuries are mostly caused by external force leading to blocked meridians and blood stasis, resulting in pain due to obstruction. Rheumatic pain is caused by wind, cold, and dampness invading the body, blocking the meridians, and hindering the flow of qi and blood. Currently, there are many types of medicated wines for traumatic injuries on the market, but most of them have problems such as short-lasting effects, slow onset of action, or poor efficacy for stubborn rheumatic pain and old traumatic injuries.

[0003] Traditional ethnic medicines contain a wealth of medicinal materials for treating bone injuries, such as Zhuang medicine's Zhan Gu and Tibetan medicine's Du Yi Wei, which have unique therapeutic effects. However, how to scientifically combine traditional ethnic medicines with commonly used Chinese medicines, especially how to safely use toxic medicinal materials such as Tie Bang Chui, Chuan Wu, Cao Wu, and San Fen San, and reduce their toxic side effects and enhance their efficacy through combination, remains an urgent problem to be solved in this field. Summary of the Invention

[0004] The purpose of this invention is to provide a medicinal wine for treating injuries and bone ailments that is effective, fast-acting, and highly safe.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A medicinal wine for treating injuries and bone-strengthening conditions is made from the following raw medicinal materials in parts by weight: 40-60 portions of battle bones; 20-40 parts of Asarum; Three parts, 10-20 portions; 30-50 servings of Du Yi Wei; Prepared aconite root (15-30 portions); 15-30 parts of processed Aconitum carmichaelii; 20-40 portions of star anise flower; 15-25 servings of Sichuan peppercorns; 20-40 portions of snake bone; 10-20 parts for making iron bars and hammers; 20-40 portions of Panax notoginseng; 15-25 parts of ground beetle; 25-35 parts of Achyranthes bidentata; Licorice 10-15 parts.

[0006] As a preferred embodiment of the present invention, it is made from the following raw medicinal materials in parts by weight: 50 pieces of battle bones; 30 parts of Asarum; Three parts, three times 15 portions; 40 servings of Du Yi Wei; Prepare 20 portions of Sichuan aconite; 20 parts of processed aconite root; 30 portions of star anise flower; 20 servings of Sichuan peppercorns; 30 portions of snake bones; 15 iron-making hammers; 30 portions of Panax notoginseng; 20 portions of ground beetle; 30 parts of Achyranthes bidentata; Licorice 12 parts.

[0007] Furthermore, the processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum carmichaelii are processed medicinal slices that have undergone detoxification treatment; the snake bone is a product processed by sand-frying.

[0008] Furthermore, the medicinal wine is a topical application.

[0009] Compared with the prior art, the beneficial effects of the present invention are: By combining ethnic medicinal materials such as bone and snake bone with blood-activating and pain-relieving herbs, and through specific processing and compatibility of toxic herbs, the effects of reducing toxicity and increasing efficacy are achieved. It has a penetrating power that can penetrate bones and remove wind, especially for injuries from falls and blows, and pain in muscles and bones and joint discomfort caused by wind-cold-dampness. Detailed Implementation

[0010] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0011] Example 1 1. Formula (parts by weight) This embodiment provides a medicinal wine for treating injuries and bone-strengthening conditions, with the following formula: 50g of *Zhan Gu* (a type of herb), 30g of *Xi Xin* (a type of herb), 15g of *San Fen San* (a type of herb), 40g of *Du Yi Wei* (a type of herb), 20g of *Zhi Chuan Wu* (a type of herb), 20g of *Zhi Cao Wu* (a type of herb), 30g of *Ba Jiao Feng Hua* (a type of herb), 20g of *Chuan Jiao* (a type of herb), 30g of *She Gu* (a type of herb), 15g of *Zhi Tie Bang Chui* (a type of herb), 30g of *San Qi* (a type of herb), 20g of *Tu Bie Chong* (a type of herb), 30g of *Niu Xi* (a type of herb), and 12g

[0012] 2. Preparation method 2.1 Raw material pretreatment: (1) Remove any remaining tendons and muscles from the snake bones, wash them, and air dry them in the shade. Place it in heated sand and stir-fry over low heat until it turns yellow. Remove it, sift out the sand, let it cool, and grind it into coarse powder for later use. (2) Mix the processed Aconitum carmichaelii, processed Aconitum kusnezoffii, processed Aconitum carmichaelii, and processed Aconitum carmichaelii in three parts, crush them into coarse powder, moisten them with 50-60% ethanol, seal them and let them stand for 1-2 hours for later use (this is the conventional pretreatment before percolation). (3) Wash, dry, and grind hard medicinal materials such as bone, notoginseng, achyranthes, and licorice into coarse powder for later use.

[0013] (4) Grind the following medicinal materials into powder as appropriate and set aside.

[0014] 2.2 Extraction (Percolation): (1) Mixing and filling: Mix all the above-mentioned processed medicinal materials thoroughly and evenly. Take a clean percolator, put a layer of degreased cotton at the bottom, and fill the percolator with the mixed medicinal powder in batches. After each filling, press it with a wooden mallet. After filling, cover it with a layer of gauze and press it with a heavy object (such as clean pebbles) to prevent the medicinal powder from floating.

[0015] (2) Liquid soaking: Close the bottom of the percolator, slowly add 55-degree pure grain liquor (base liquor) into the cylinder until the liquid level is about 3-5 cm above the powder surface, and keep a small amount of liquid remaining. Cover the cylinder and soak at room temperature for 48 hours.

[0016] (3) Percolation and collection: After soaking for 48 hours, open the bottom valve to start percolation. Control the percolation rate to 1-3 ml per minute per kilogram of medicinal material. Add new wine while percolating to keep the liquid level above the powder. Collect the percolate. The first 800 ml collected (about 1 times the total amount of medicinal material) is concentrated percolate and should be stored in a separate container. Continue percolation and collect about 4000 ml of the subsequent percolate (about 5 times the total amount of medicinal material).

[0017] (4) Combining and mixing: The continuous percolation is concentrated under reduced pressure at a temperature below 60°C to a thick paste with a relative density of 1.05-1.10. After cooling, it is mixed with the initially collected concentrated percolation, stirred evenly, and left to stand for 24 hours.

[0018] (5) Filtration and dispensing: Take the mixture after it has been left to stand, filter it, and fill the filtrate into bottles to obtain the medicated wine for traumatic bone and joint pain of the present invention.

[0019] 2.3 Precautions: This product contains aconitine and hyoscyamine alkaloids, which are toxic traditional Chinese medicines. It is for external use only and must not be taken orally. Apply externally to the affected area 3-4 times a day.

[0020] Example 2 The difference between this embodiment and Embodiment 1 lies in the different weight proportions of the formula: 40g of *Zhan Gu* (a type of herb), 20g of *Xi Xin* (another herb), 10g of *San Fen San* (another herb), 30g of *Du Yi Wei* (another herb), 15g of *Zhi Chuan Wu* (a type of herb), 15g of *Zhi Cao Wu* (a type of herb), 20g of *Ba Yan Feng Hua* (a type of herb), 15g of *Chuan Jiao* (a type of herb), 20g of *She Gu* (a type of herb), 10g of *Zhi Tie Bang Chui* (a type of herb), 20g of *San Qi* (a type of herb), 15g of *Tu Bie Chong* (a type of herb), 25g of *Niu Xi* (a type of herb), and 10g of *Gan Cao

[0021] Example 3 The difference between this embodiment and Embodiment 1 lies in the different weight proportions of the formula: 60g of *Zhan Gu* (a type of herb), 40g of *Xi Xin* (another herb), 20g of *San Fen San* (another herb), 50g of *Du Yi Wei* (another herb), 30g of *Zhi Chuan Wu* (a type of herb), 30g of *Zhi Cao Wu* (a type of herb), 40g of *Ba Yan Feng Hua* (a type of herb), 25g of *Chuan Jiao* (a type of herb), 40g of *She Gu* (a type of herb), 20g of *Zhi Tie Bang Chui* (a type of herb), 40g of *San Qi* (a type of herb), 25g of *Tu Bie Chong* (a type of herb), 35g of *Niu Xi* (a type of herb), and 15g of *Gan Cao

[0022] Comparative Example 1 (Verification of Toxicity and Compatibility) This comparative example is used to verify the detoxification effect of licorice, Sichuan pepper and other adjuvant drugs in this invention. Except for removing licorice and Sichuan pepper, the other medicinal materials and dosages are the same as in Example 1, and the preparation method is the same as in Example 1.

[0023] Pharmacodynamics and safety studies 1. Skin irritation test Six healthy rabbits, half male and half female, were selected. After the hair on their backs was removed, the medicinal wine prepared in Example 1 of this invention, the medicinal wine prepared in Comparative Example 1, and the blank solvent were applied to them respectively. The application was carried out once a day for 7 consecutive days. Results: No erythema, edema or other irritation reactions were observed in the rabbits in Example 1 group; two rabbits in Comparative Example 1 group showed mild erythema, indicating that the irritation of the formula increased slightly after removing licorice and Sichuan pepper, proving that the formulation of the present invention has a beneficial effect in reducing irritation.

[0024] 2. Anti-inflammatory test (mouse ear swelling method) Forty Kunming mice were randomly divided into four groups: Blank control group (matrix), positive control group (a well-known commercially available liniment for bruises and sprains), Example 1 group, and comparative example 1 group. Each group of mice had 0.1 ml of the corresponding drug applied to their right ear, with the left ear serving as a control. One hour after drug administration, xylene was dripped into the right ear of the mice to induce inflammation. The mice were sacrificed 30 minutes later, and ear flaps from the same location on both ears were removed using a punch and weighed. The weight difference between the two ear flaps was used to indicate the degree of swelling.

[0025] result: Swelling level in the blank control group: 15.22.1 mg Swelling degree in the positive control group: 8.5-1.8 mg Swelling degree in Example 1 group: 5.6-1.3 mg Comparative Example 1: Swelling level: 6.1-1.5 mg Conclusion: The medicinal wine of Example 1 of the present invention has a significant inhibitory effect on xylene-induced ear swelling in mice, and its effect is better than that of commercially available positive control drugs, and slightly better than that of Comparative Example 1 which removes licorice and Sichuan pepper. This shows that the formulation of the present invention has excellent anti-inflammatory and swelling-reducing effects.

[0026] In summary, the medicated wine for traumatic injuries and bone-strengthening conditions provided by this invention, through specific combinations of medicinal materials and preparation processes, exerts significant effects in promoting blood circulation, removing blood stasis, dispelling wind and dampness, reducing swelling and relieving pain. Furthermore, the rational combination of adjuvants reduces the irritation of toxic medicinal materials, making it effective, safe to use, and suitable for clinical application.

[0027] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "include," "contain," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus.

[0028] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medicinal wine for treating injuries and bone-strengthening ailments, characterized in that, Made from the following raw medicinal materials in parts by weight: 40-60 parts of *Zhan Gu* (a type of medicinal herb); 20-40 parts of *Xi Xin* (another type of medicinal herb); 10-20 parts of *San San San* (another type of medicinal herb); 30-50 parts of *Du Yi Wei* (another type of medicinal herb); 15-30 parts of processed *Chuan Wu* (a type of medicinal herb); 15-30 parts of processed *Cao Wu* (a type of medicinal herb); 20-40 parts of *Ba Jiao Feng Hua* (a type of medicinal herb); 15-25 parts of *Chuan Jiao* (a type of medicinal herb); 20-40 parts of snake bone; and 10-20 parts of processed *Tie Bang Chui* (a type of medicinal herb). Panax notoginseng 20-40 parts; Eupolyphaga sinensis 15-25 parts; Achyranthes bidentata 25-35 parts; Glycyrrhiza uralensis 10-15 parts.

2. The medicinal wine for treating injuries and bone-strengthening conditions according to claim 1, characterized in that, Made from the following raw medicinal materials in parts by weight: 50 parts of *Zhan Gu* (a type of medicinal herb); 30 parts of *Xi Xin* (another type of medicinal herb); 15 parts of *San San San* (another type of medicinal herb); 40 parts of *Du Yi Wei* (another type of medicinal herb); 20 parts of *Zhi Chuan Wu* (a type of medicinal herb); 20 parts of *Zhi Cao Wu* (a type of medicinal herb); 30 parts of *Ba Yan Feng Hua* (a type of medicinal herb); 20 parts of *Chuan Jiao* (a type of medicinal herb); 30 parts of snake bone; 15 parts of *Zhi Tie Bang Chui* (a type of medicinal herb); 30 parts of *San Qi* (a type of medicinal herb). 20 parts of ground beetle; 30 parts of achyranthes bidentata; 12 parts of licorice.

3. A medicinal wine for treating injuries and bone-strengthening conditions according to claim 1 or 2, characterized in that: The processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum carmichaelii are processed medicinal slices that have undergone detoxification treatment; the snake bone is a product processed by sand-frying.

4. A medicinal wine for treating injuries and bone-strengthening conditions according to claim 1 or 2, characterized in that: The medicinal wine is for external use.