Enema device and method for colonization of probiotics through anus

Abstract

The invention relates to the technical field of medical instruments, in particular to a transanal probiotic colonization enema device and method.The transanal probiotic colonization enema device comprises a transparent scale liquid storage bag and an annular bag belt, the outer wall of the transparent scale liquid storage bag is sleeved with the annular bag belt, and the inner wall of the annular bag belt is fixedly connected with a constant-temperature heater; the outer wall of the transparent scale liquid storage bag is wrapped with a paraffin-based composite layer, the lower surface of the transparent scale liquid storage bag is fixedly connected with a medical silica gel catheter through a Luer taper, gastric acid and bile inactivation barriers are bypassed through rectal administration, the survival rate of probiotics is greatly increased, the probiotics directly reach the colon diseased region in a targeted mode, and the survival rate of the probiotics is increased. High-concentration florae are in accurate contact with intestinal mucosa, the colonic colonization rate is increased, the symptom relieving period is shortened, the device is easy and convenient to assemble and suitable for families and basic medical scenes, double leakage prevention is achieved through the annular bag, the funnel-shaped abutting piece and the leakage-proof and backflow-proof valve, leakage is eradicated, tissue damage is reduced through the arc-shaped tip design, and the use comfort is improved through self-adaptive sealing.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to an enema device and method for colonizing probiotics through the anus. Background Technology

[0002] Enema devices are medical devices specifically designed to deliver enema fluid into the rectum / colon via the anus for purposes such as relieving constipation, cleansing, administering medication, or preparing for diagnosis. Their core functions include softening and removing stool, relieving abdominal distension, preoperative bowel preparation, and local drug delivery.

[0003] Oral probiotic preparations have low survival rates. Inactivation by gastric acid and bile leads to low probiotic survival rates and poor colonization efficiency. Only a small number of bacteria can reach the colon, resulting in a low colonization rate. Some enema devices are expensive, complex to operate, and lack dedicated functions for probiotic colonization. In order to solve the above problems, this invention proposes an enema device for transanal probiotic colonization. Summary of the Invention

[0004] To address the problems in the prior art, this invention provides an enema device and method for transanal probiotic colonization.

[0005] The technical solution adopted by the present invention to solve its technical problem is: an enema device for colonizing probiotics through the anus, including a transparent graduated liquid storage bag and an annular sac, the outer wall of the transparent graduated liquid storage bag is fitted with an annular sac, the inner wall of the annular sac is fixedly connected with a constant temperature heater, and the outer wall of the transparent graduated liquid storage bag is wrapped with a paraffin-based composite layer. A medical silicone catheter is fixedly connected to the middle of the lower surface of the transparent graduated liquid storage bag via a Luer connector. The end of the medical silicone catheter away from the transparent graduated liquid storage bag is fixedly connected to an annular bag-shaped rectal cannula for leak prevention.

[0006] Specifically, a hanging strap is fixedly connected to the upper surface of the transparent graduated liquid storage bag, and the hanging strap is used to suspend and fix the transparent graduated liquid storage bag.

[0007] Specifically, the outer wall of the medical silicone catheter is provided with an adjusting valve, and the flow rate adjustment range of the adjusting valve is 0.5-1.5ml / s.

[0008] Specifically, the lower surface of the annular bag is provided with a flow hole at the end away from the medical silicone catheter and is fixedly connected to a flow control valve. The connection between the annular bag and the rectal cannula is provided with a funnel-shaped abutment, which cooperates with the annular bag to form a double seal.

[0009] Specifically, the upper surface of the annular bag is provided with a flow hole at the end away from the medical silicone catheter and is fixedly connected with an anti-reflux valve. The anti-reflux valve is provided with a silicone valve and a pressure sensing spring inside.

[0010] Specifically, the end of the annular pouch-shaped anti-leakage rectal cannula furthest from the medical silicone catheter is set with an arc-shaped tip, and an anti-leakage and anti-backflow valve is fixedly connected to the contact surface between the annular pouch-shaped anti-leakage rectal cannula and the medical silicone catheter, and the opening and closing angle of the anti-leakage and anti-backflow valve is 15°-75°.

[0011] Specifically, the constant temperature heater can heat the paraffin-based composite layer with low power through contact, and the constant temperature heater can maintain the temperature of the bacterial liquid in the transparent graduated storage bag through the paraffin-based composite layer.

[0012] The enema method for colonizing probiotics through the anus includes the following steps: First, confirm that the transparent graduated reservoir bag, annular bag, constant temperature heater, medical silicone tubing, annular bag leak-proof rectal cannula, strap, flow control valve, anti-backflow valve, and leak-proof and anti-backflow valve are undamaged. All parts that come into contact with the bacterial solution, such as the reservoir bag, tubing, cannula, and valves, are sterilized to avoid cross-infection. Highly active strains such as lactic acid bacteria and bifidobacteria were selected to prepare bacterial solutions with a concentration of 10^8-10^10 CFU / mL. The pH value of the bacterial solution was controlled at 6.5-7.5 and the volume at 30-50 ml. The temperature of the bacterial solution was pre-adjusted to 35-37°C. The prepared bacterial solution was injected into a transparent graduated storage bag. The constant temperature heater was started, and the paraffin-based composite layer was heated through a temperature feedback system to maintain the temperature of the bacterial solution at 35-37°C. The phase transition point of the paraffin-based composite layer was 36.5±0.5°C. The second step is to use the straps on the upper surface of the transparent graduated storage bag to suspend the storage bag at a suitable height to ensure that the bacterial solution can flow and be poured naturally. Check the sealing of the annular bag and fill the annular bag with liquid through the flow hole to make it ready to be sealed, ensuring that it can adapt to the anal size. Open the flow control valve and test whether the flow rate adjustment range is 0.5-1.5ml / s. Check the sealing of the silicone valve, pressure sensing spring, and anti-leakage anti-backflow valve inside the anti-backflow valve. The silicone valve and pressure sensing spring can be adjusted within the opening angle of 15°-75° to ensure that the reverse sealing pressure meets the standard and there is no risk of backflow. The reverse sealing pressure is 50-120mmHg. Assist the patient to take a left or right lateral decubitus position, place a sheet under the buttocks to prevent staining clothing, move the buttocks to the edge of the bed, remove the pants to fully expose the anus, raise the buttocks 10cm with a small pillow, bend the upper leg and straighten the lower leg, and keep the body position comfortable and stable. The third step is to fully lubricate the arc-shaped tip and outer wall of the annular bag leak-proof rectal cannula with paraffin oil or common edible oil to reduce tissue damage during insertion. Slowly insert the annular bag leak-proof rectal cannula into the patient's anus, controlling the insertion depth to 8-15cm, to ensure that the cannula reaches the appropriate intestinal position. The annular bag is filled with fluid to form a primary leak-proof seal, and the funnel-shaped abutment is used to cooperate with the annular bag to form a secondary leak-proof seal, ensuring that there is no leakage at the anus. Fourth, slowly open the flow control valve and adjust the flow rate to 0.5-1.5 ml / s to allow the bacterial solution to be injected into the intestine at a uniform speed along the medical silicone catheter. During the process, observe the liquid level changes in the transparent graduated reservoir bag to ensure smooth perfusion. After the bacterial solution is completely injected, inject 15 ml of normal saline to flush the catheter and ensure that all residual bacterial solution in the catheter enters the intestine. During the perfusion process, continuously ask the patient about their feelings. If abdominal pain, abdominal distension, palpitations, or other discomfort occurs, immediately close the valve, stop the perfusion, and take appropriate measures. Step 5: After flushing, instruct the patient to clench their anus. Slowly and evenly remove the annular pouch-shaped rectal tube to prevent leakage. After removal, gently massage the anus to help it close. Rotate the examination bed 15-20 degrees to a head-down, feet-up position. The patient should then roll over twice on the examination bed to maintain a prone position for 3-5 minutes to promote full contact and application of the compound probiotic solution to the colon. The patient should avoid using the toilet as much as possible. If irritable bowel symptoms require toileting, ensure that the irrigation solution is retained for at least 1 hour to ensure full absorption of the probiotics by the intestinal wall. As the device is designed for single use, it should be disposed of according to medical waste regulations and cannot be reused.

[0013] The beneficial effects of this invention are: (1) The enema device and method for transanal probiotic colonization described in this invention bypasses the gastric acid and bile inactivation barrier by administering the medication through the rectum, thereby significantly improving the survival rate of probiotics. It targets the lesion site in the colon directly, and the high concentration of bacteria accurately contacts the intestinal mucosa, improving the colon colonization rate and shortening the symptom relief period. The device is easy to assemble and suitable for home and primary healthcare scenarios. It has a double leak-proof structure consisting of an annular sac, a funnel-shaped contact piece, and a leak-proof and anti-backflow valve to prevent leakage. The arc-shaped tip design reduces tissue damage, and the adaptive sealing improves the comfort of use. Attached Figure Description

[0014] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0015] Fig. 1 This is a front view structural diagram of the enema device for transanal probiotic colonization provided by the present invention; Fig. 2 A front view of the transparent graduated liquid storage bag of the enema device for transanal probiotic colonization provided by the present invention; Fig. 3This is a cross-sectional schematic diagram of the anti-leakage and anti-backflow valve of the enema device for transanal probiotic colonization provided by the present invention.

[0016] In the diagram: 1. Transparent graduated reservoir bag; 2. Annular sac bag; 3. Thermostatic heater; 4. Medical silicone catheter; 5. Annular sac bag leak-proof rectal cannula; 6. Sling; 7. Regulating valve; 8. Flow control valve; 9. Leak-proof and backflow-proof valve; 10. Leak-proof and backflow-proof valve. Detailed Implementation

[0017] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0018] like Figs. 1-3 As shown, the present invention provides the following technical solution: Example 1: An enema device for colonizing probiotics through the anus includes a transparent graduated liquid storage bag 1 and an annular sac 2. The outer wall of the transparent graduated liquid storage bag 1 is fitted with the annular sac 2, and the inner wall of the annular sac 2 is fixedly connected to a constant temperature heater 3. The outer wall of the transparent graduated liquid storage bag 1 is wrapped with a paraffin-based composite layer. A medical silicone catheter 4 is fixedly connected to the middle of the lower surface of the transparent graduated liquid storage bag 1 via a Luer connector. The end of the medical silicone catheter 4 away from the transparent graduated liquid storage bag 1 is fixedly connected to an annular bag leak-proof rectal catheter 5.

[0019] The upper surface of the transparent graduated liquid storage bag 1 is fixedly connected with a hanging strap 6, which is used to suspend and fix the transparent graduated liquid storage bag 1.

[0020] The outer wall of the medical silicone catheter 4 is equipped with a regulating valve 7, and the flow rate of the regulating valve 7 is adjustable in the range of 0.5-1.5 ml / s.

[0021] The lower surface of the annular bag 2, away from the end of the medical silicone catheter 4, is provided with a flow hole and a flow control valve 8 is fixedly connected thereto. The connection between the annular bag leak-proof rectal cannula 5 and the medical silicone catheter 4 is provided with a funnel-shaped abutment, which cooperates with the annular bag 2 to form a double seal.

[0022] Among them, the upper surface of the annular bag 2 is provided with a flow hole at the end away from the medical silicone catheter 4 and is fixedly connected with an anti-backflow valve 9. The anti-backflow valve 9 is provided with a silicone valve and a pressure sensing spring inside.

[0023] Among them, the end of the annular pouch anti-leakage rectal cannula 5 away from the medical silicone catheter 4 is set with an arc-shaped tip. The contact surface between the annular pouch anti-leakage rectal cannula 5 and the medical silicone catheter 4 is fixedly connected with an anti-leakage and anti-backflow valve 10, and the opening and closing angle of the anti-leakage and anti-backflow valve 10 is 15°-75°.

[0024] Among them, the constant temperature heater 3 can heat the paraffin-based composite layer by low power contact, and the constant temperature heater 3 can maintain the temperature of the bacterial liquid in the transparent graduated storage bag 1 through the paraffin-based composite layer.

[0025] Before use, ensure that the following components are undamaged: transparent graduated reservoir bag 1, annular bag 2, constant temperature heater 3, medical silicone catheter 4, annular bag leak-proof rectal cannula 5, strap 6, flow control valve 7, anti-backflow valve 9, and leak-proof and anti-backflow valve 10. Perform aseptic disinfection on all components in contact with the bacterial solution, such as the reservoir bag, catheter, cannula, and valves, to avoid cross-contamination. Select highly active strains of lactic acid bacteria and bifidobacteria to prepare a bacterial solution with a concentration of 10^8-10^10 CFU / mL, controlling the pH of the bacterial solution to 6.5-7.5 and the volume to 30-50 ml. The bacterial solution temperature is pre-adjusted to 35-37°C. The prepared bacterial solution is then injected into the transparent graduated storage bag 1. The constant temperature heater 3 is activated, and the paraffin-based composite layer is heated via a temperature feedback system to maintain the bacterial solution temperature at a stable 35-37°C. The phase transition point of the paraffin-based composite layer is 36.5±0.5°C. Using the hanging strap 6 on the upper surface of the transparent graduated storage bag 1, the storage bag is suspended at a suitable height to ensure natural flow and infusion of the bacterial solution. The sealing performance of the annular bag 2 is checked, and liquid is injected into the annular bag 2 through the flow orifice to prepare it for sealing, ensuring it can adapt to the anus. Check the dimensions, open the flow control valve 7, and test if the flow rate adjustment range is 0.5-1.5 ml / s. Check the sealing of the silicone valve, pressure sensing spring, and anti-leakage anti-backflow valve 10 inside the anti-backflow valve 9. The silicone valve and pressure sensing spring are adjustable within the opening angle of 15°-75° to ensure that the reverse sealing pressure meets the standard and there is no risk of backflow. The reverse sealing pressure is 50-120 mmHg. Assist the patient to assume a left or right lateral decubitus position, place a sheet under the buttocks to prevent staining clothing, move the buttocks to the edge of the bed, remove the pants to fully expose the anus, and elevate the buttocks 10 cm with a small pillow. m, with the upper leg bent and the lower leg straight, maintain a comfortable and stable position. Thoroughly lubricate the curved tip and outer wall of the annular bag leak-proof rectal cannula 5 with paraffin oil or common edible oil to reduce tissue damage during insertion. Slowly insert the annular bag leak-proof rectal cannula 5 into the patient's anus, controlling the insertion depth to 8-15cm, ensuring the cannula reaches the appropriate intestinal position. The annular bag 2 expands under fluid to form a primary leak-proof seal, and the funnel-shaped abutment cooperates with the annular bag to form a secondary leak-proof seal, ensuring no leakage at the anus. Slowly open the flow control valve 7 and adjust the flow rate to 0.5-1.Inject the bacterial solution at a constant rate of 5 ml / s into the intestine via the medical silicone catheter 4. Observe the liquid level changes in the transparent graduated reservoir bag 1 during the process to ensure smooth infusion. After the bacterial solution is infused, flush the catheter with 15 ml of normal saline to ensure that all residual bacterial solution enters the intestine. Continuously inquire about the patient's feelings during the infusion process. If abdominal pain, bloating, palpitations, or other discomfort occurs, immediately close the valve, stop the infusion, and take appropriate measures. After flushing, instruct the patient to clench their anus and slowly and evenly remove the annular pouch to prevent rectal leakage. 5. After intubation and removal of the tube, gently massage the anus to help it close. Rotate the examination bed 15º-20º to a head-down, feet-up position. The patient should then roll over twice on the examination bed to maintain a prone position for 3-5 minutes to promote full contact and application of the probiotic solution to the colon. The patient should avoid urinating as much as possible. If irritable bowel symptoms necessitate urination, ensure the irrigation solution is retained for at least 1 hour to guarantee sufficient absorption of the probiotics by the intestinal wall. As the device is a disposable design, it should be disposed of according to medical waste regulations and cannot be reused.

[0026] Experimental comparison method: The experimental group adopted the rectal targeted probiotic supplementation method. Using a self-made transanal rectal targeted probiotic enema device, 50ml of compound probiotic saline solution was injected into the colon of volunteers. The compound probiotic contained 4g of compound probiotics, with a live bacteria input of ≥6 billion CFU during production. The probiotic was Puzelex compound probiotic, and the main components were Bifidobacterium V9, Lactobacillus casei LC001, Lactobacillus acidophilus NM, orange powder, maltodextrin, and isomaltooligosaccharide. Prepare the necessary supplies for the enema, including a homemade transanal rectal targeted probiotic enema device, thermometer, spare rectal tube, toilet paper, paraffin oil or common cooking oil, and a diaper sheet. Before the enema, empty your bladder and bowels, adjust the air conditioner to make the room temperature comfortable to prevent catching a cold, draw the curtains, close the doors and windows, and pay attention to protecting privacy. During the enema, position the patient in a left or right lateral decubitus position with a sheet under the buttocks to prevent contamination of the sheets and the patient's clothing. Move the buttocks to the edge of the bed, remove the pants, and fully expose the anus. Use a small pillow to elevate the buttocks by 10cm. Bend the upper leg and straighten the lower leg. Lubricate the anal tube with paraffin oil. Slowly insert the enema device into the anus to a depth of 15-20cm and slowly inject the probiotic mixture. During the enema, instruct the volunteer to inform the operator immediately if they experience any discomfort such as abdominal pain, bloating, or palpitations. The operator will then slow down the enema rate or stop the enema. After the medication is finished, inject a small amount of saline to flush the tube into the intestine. Then, instruct the volunteer to clench the anus, remove the tube at a steady pace, gently massage the anus, put on clothing, and the procedure is complete. After instillation, rotate the examination bed 15º–20º to a head-down, feet-up position, and roll over twice on the examination bed to maintain a prone position for 3–5 minutes to promote full contact and application of the compound probiotic solution to the colon. Volunteers are advised to avoid defecation as much as possible. For volunteers with irritable bowel symptoms who need to defecate, they are required to retain the instillation solution for at least 1 hour before defecating to allow for full absorption of the compound probiotic solution by the intestinal wall. After defecation, monitor the stool and record the findings. The experimental group received infusions of compound probiotics every Monday, Wednesday, Friday, and Sunday morning for four weeks. The control group took 2g of compound probiotics with 50ml of room temperature water twice a day, morning and evening, for a total of 4g / day. The total amount of compound probiotics was 4g, which contained approximately ≥6 billion CFU of live bacteria during production. The probiotics were Probiotics Probiotics, and the main components were Bifidobacterium V9, Lactobacillus casei LC001, Lactobacillus acidophilus NM, orange powder, maltodextrin, and isomaltooligosaccharide, for four weeks. The efficacy of treatment was assessed by observing patient symptoms. Effective treatment was indicated by a significant disappearance of clinical symptoms and signs, with a symptom score reduction of over 80%. Improvement was indicated by a 50%–80% reduction in scores, while ineffective treatment was indicated by no improvement in symptoms and signs and a score reduction of less than 20%. Stool samples were collected from patients before and after treatment and sent to the laboratory for analysis. Bifidobacterium V9, Lactobacillus casei LC001, and Lactobacillus acidophilus NM were cultured using their respective culture dishes. The genus level was determined using a three-level bacterial identification method, and the logarithm of the bacterial count was recorded. The colonization rate of probiotics in the volunteers' intestines was monitored every 48 hours. Various physiological indicators and intestinal flora counts were measured weekly to observe the effects of the two supplementation methods on health. Neither the experimental group nor the control group was allowed to take any antibiotics during the experimental period to avoid affecting the experimental results.

[0027] Example 1: Treatment data of patients with chronic diarrhea

[0028]

[0029] Example 2: Outcomes of Irritable Bowel Syndrome Management

[0030] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by the present invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. An enema device for colonizing probiotics through the anus, comprising a transparent graduated liquid storage bag (1) and an annular sac (2), wherein the outer wall of the transparent graduated liquid storage bag (1) is fitted with an annular sac (2), and the inner wall of the annular sac (2) is fixedly connected with a constant temperature heater (3), and the outer wall of the transparent graduated liquid storage bag (1) is wrapped with a paraffin-based composite layer; Its features are: A medical silicone catheter (4) is fixedly connected to the middle position of the lower surface of the transparent graduated liquid storage bag (1) via a Luer connector. An annular bag leak-proof rectal catheter (5) is fixedly connected to the end of the medical silicone catheter (4) away from the transparent graduated liquid storage bag (1).

2. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The upper surface of the transparent graduated liquid storage bag (1) is fixedly connected with a hanging strap (6), which is used to suspend and fix the transparent graduated liquid storage bag (1).

3. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The outer wall of the medical silicone catheter (4) is provided with a regulating valve (7), and the flow rate of the regulating valve (7) is 0.5-1.5 ml / s.

4. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The lower surface of the annular bag (2) is provided with a flow hole at the end away from the medical silicone catheter (4) and a flow control valve (8) is fixedly connected thereto. The connection between the annular bag leak-proof rectal cannula (5) and the medical silicone catheter (4) is provided with a funnel-shaped abutment. The funnel-shaped abutment and the annular bag (2) cooperate to form a double seal.

5. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The upper surface of the annular bag (2) is provided with a flow hole at the end away from the medical silicone catheter (4) and is fixedly connected with an anti-backflow valve (9). The anti-backflow valve (9) is provided with a silicone valve and a pressure sensing spring inside.

6. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The end of the annular pouch leak-proof rectal cannula (5) away from the medical silicone catheter (4) is set with an arc-shaped tip. The contact surface between the annular pouch leak-proof rectal cannula (5) and the medical silicone catheter (4) is fixedly connected with a leak-proof and anti-backflow valve (10). The opening and closing angle of the leak-proof and anti-backflow valve (10) is 15°-75°.

7. The enema device for transanal probiotic colonization according to claim 1, characterized in that: The constant temperature heater (3) can heat the paraffin-based composite layer with low power in contact, and the constant temperature heater (3) can maintain the temperature of the bacterial liquid in the transparent graduated storage bag (1) through the paraffin-based composite layer.

8. A method for enema colonization of probiotics via the anus, comprising the enema apparatus for colonization of probiotics via the anus as described in any one of claims 1-7, characterized in that: Includes the following steps: The first step is to confirm that the transparent graduated storage bag (1), the annular bag (2), the constant temperature heater (3), the medical silicone catheter (4), the annular bag leak-proof rectal cannula (5), the strap (6), the flow control valve (7), the anti-backflow valve (9), and the leak-proof and anti-backflow valve (10) are undamaged. All parts that come into contact with the bacterial solution, such as the storage bag, catheter, cannula, and valve, are sterilized to avoid cross-infection. Select highly active strains such as lactic acid bacteria and bifidobacteria to prepare bacterial solutions with a concentration of 10^8-10^10 CFU / mL. Control the pH value of the bacterial solution to 6.5-7.5 and the volume to 30-50 ml. Pre-adjust the temperature of the bacterial solution to 35-37°C. Inject the prepared bacterial solution into a transparent graduated storage bag (1). Start the constant temperature heater (3). Heat the paraffin-based composite layer through the temperature feedback system to maintain the temperature of the bacterial solution at 35-37°C. The phase transition point of the paraffin-based composite layer is 36.5±0.5°C. The second step is to use the strap (6) on the upper surface of the transparent graduated storage bag (1) to hang the storage bag at a suitable height to ensure that the bacterial solution can flow and be injected naturally. Check the sealing of the annular bag (2) and fill the annular bag (2) with liquid through the flow hole to make it in a state of waiting to be sealed, so as to ensure that it can adapt to the anal size. Open the flow control valve (7) and test whether the flow rate adjustment range is 0.5-1.5ml / s. Check the sealing of the silicone valve, pressure sensing spring and anti-leakage anti-backflow valve (10) in the anti-backflow valve (9). The silicone valve and pressure sensing spring can be adjusted within the opening angle of 15°-75° to ensure that the reverse sealing pressure meets the standard and there is no risk of backflow. The reverse sealing pressure is 50-120mmHg. Assist the patient to take a left or right lateral decubitus position, put a sheet under the buttocks to prevent staining of clothing, move the buttocks to the edge of the bed, take off the pants to fully expose the anus, raise the buttocks 10cm with a small pillow, bend the upper leg and straighten the lower leg to keep the body position comfortable and stable. The third step is to fully lubricate the arc-shaped tip and outer wall of the annular bag leak-proof rectal cannula (5) with paraffin oil or common edible oil to reduce tissue damage during insertion. Slowly insert the annular bag leak-proof rectal cannula (5) into the patient's anus, with the insertion depth controlled at 8-15cm, to ensure that the cannula reaches the appropriate intestinal position. The annular bag (2) is filled with fluid to form a first-level leak-proof seal. The funnel-shaped abutment is used to cooperate with the annular bag to form a second-level leak-proof seal, ensuring that there is no leakage at the anus. Fourth step, slowly open the flow control valve (7) and adjust the flow rate to 0.5-1.5 ml / s so that the bacterial solution is injected into the intestine at a uniform speed along the medical silicone catheter (4). During the process, observe the liquid level change of the transparent graduated storage bag (1) to ensure smooth perfusion. After the bacterial solution is perfused, inject 15 ml of physiological saline to flush the catheter to ensure that all the residual bacterial solution in the catheter enters the intestine. During the perfusion process, continuously ask the patient about their feelings. If abdominal pain, abdominal distension, palpitations or other discomfort occurs, immediately close the valve, stop the perfusion and take appropriate measures. Step 5: After flushing the tube, instruct the patient to clamp the anus and slowly pull out the annular bag-shaped rectal tube (5). After removing the tube, gently massage the anus to help close it. Rotate the examination bed 15º-20º to a head-down, feet-up position and roll over twice on the examination bed to maintain a prone position for 3-5 minutes to promote full contact and application of the compound probiotic solution to the colon. The patient is asked to avoid going to the toilet as much as possible. If there are symptoms of intestinal irritation and the patient needs to go to the toilet, the irrigation solution must be retained for at least 1 hour to ensure that the intestinal wall fully absorbs the probiotics. Since the device is designed for single use, it should be disposed of in accordance with medical waste regulations after use and cannot be reused.

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