Full-intelligent platelet-rich plasma preparation device

Abstract

The invention provides a full-intelligent platelet-rich plasma preparation device, and belongs to the technical field of platelet-rich plasma preparation. A device housing; the upper cover plate is located at the opening of the equipment shell; the centrifugal machine body is located in the equipment shell, and a motor of the centrifugal machine body is fixed to the bottom of the equipment shell; the test tube mounting disc is positioned in the centrifugal machine body; the plurality of test tubes are positioned in the test tube mounting disc; by integrating the intelligent sensing module and the control decision module, automatic operation of the whole process from blood collection, centrifugation, monitoring, separation to output is achieved, dependence on artificial experience is avoided, the system can automatically optimize centrifugal parameters and complete accurate extraction according to the characteristics and the layering state of the blood sample collected in real time, and the operation efficiency is improved. The standardization degree of operation and the consistency between batches are remarkably improved, and the quality fluctuation and pollution risk caused by manual operation are reduced.

Description

Technical Field

[0001] This invention belongs to the field of platelet-rich plasma preparation technology, specifically relating to a fully intelligent platelet-rich plasma preparation device. Background Technology

[0002] Platelet-rich plasma (PRP) is a platelet concentrate obtained by centrifuging whole blood. It is rich in various growth factors and is widely used in orthopedics, sports medicine, plastic surgery, dentistry, and chronic wound repair.

[0003] The patent application CN115475416A discloses a platelet-rich plasma (PRP) preparation mechanism, comprising a first outer chamber, an isolation plug inside the first outer chamber, and a second outer chamber, which are connected and fixedly connected. The isolation plug has a valve hole that connects the cavity of the first outer chamber and the inner cavity of the second outer chamber. A hollow separation valve core is located inside the second outer chamber, and the separation valve core is movably connected to a second chamber end cap. The bottom end of the separation valve core is closed, and a sealing gasket is located at the top opening of the separation valve core. A flow hole is located on the wall of the separation valve core below the sealing gasket, connecting to the inner cavity of the separation valve core. This invention can effectively extract PRP with a low risk of contamination by other components during the extraction process.

[0004] Traditional PRP preparation methods involve the operator loading anticoagulated whole blood into centrifuge tubes, setting centrifugation parameters based on experience, visually identifying the layered interface after centrifugation, and manually extracting the PRP layer with a syringe. This method is cumbersome, relies on personal experience, and is prone to platelet loss, leukocyte contamination, or other contamination risks, resulting in significant batch-to-batch quality variations. While some commercially available PRP preparation kits use dedicated centrifuge tubes and separating gels and achieve a certain degree of standardization through preset centrifugation programs, they still require manual intervention such as blood transfer, layer identification, and extraction. They have low levels of automation and cannot dynamically adjust centrifugation parameters based on individual blood characteristics. Some institutions have attempted to use apheresis machines for PRP preparation, which can achieve large-scale processing, but the equipment is expensive, complex to operate, and not specifically designed for PRP, resulting in limited separation accuracy and platelet activity retention. Summary of the Invention

[0005] The purpose of this invention is to provide a fully intelligent platelet-rich plasma (PRP) preparation device, aiming to solve the following problems in the prior art: 1. setting centrifugation parameters based on personal experience; 2. visually identifying the layered interface after centrifugation; 3. manually extracting the PRP layer with a syringe; 4. contamination by leukocytes resulting in leukocyte-rich or leukocyte-poor PRP; 5. large batch-to-batch treatment differences.

[0006] To achieve the above objectives, the present invention provides the following technical solution: A fully intelligent platelet-rich plasma preparation device, comprising: The equipment casing has an opening at the top; A top cover plate, the top cover plate being located at the opening of the equipment housing; The centrifuge body is located inside the equipment casing, and the motor of the centrifuge body is fixed to the bottom of the equipment casing; A test tube mounting tray, which is located inside the centrifuge body; Multiple test tubes, all of which are located within a test tube mounting tray; The slurry outlet pipe and the slurry inlet pipe respectively penetrate both sides of the equipment casing; A plasma collection device, wherein the plasma collection device is fixedly connected to one side of the device housing, and one end of the plasma outlet tube is connected to the plasma collection device; Mounting bracket, which is fixedly connected to the lower end of the upper cover plate; The control core is fixed to the bottom of the device housing; A dripper, located inside the equipment housing, with the other ends of the slurry outlet pipe and the slurry inlet pipe connected to the dripper; The liquid crystal display screen is fixedly connected to the upper end of the upper cover plate; A forward and backward moving mechanism, which is located inside the equipment housing, drives the dropper to move back and forth; A left-right moving mechanism is located at the upper end of the front-back moving mechanism, which drives the entire front-back moving mechanism to move left and right. The up-and-down moving mechanism is located at the upper end of the front-and-back moving mechanism and drives the dropper to move up and down.

[0007] In a preferred embodiment of the present invention, the forward and backward moving mechanism includes a hollow plate A, a motor A, a lead screw A, and a slider A. The hollow plate A is located inside the equipment housing. The lead screw A is rotatably connected inside the hollow plate A. The motor A is fixedly connected to one side of the hollow plate A, and its output shaft passes through the hollow plate A. One end of the lead screw A is fixed to the output shaft of the motor A. The slider A is sleeved on the surface of the hollow plate A, and the slider A is threadedly connected to the lead screw A via a nut thread.

[0008] In a preferred embodiment of the present invention, the left and right moving mechanism includes a motor B, a hollow plate B, a lead screw B, and a slider B. The motor B and the hollow plate B are both fixedly connected to the lower end of the mounting bracket. The output shaft of the motor B passes through the hollow plate B. The lead screw B is rotatably connected to the hollow plate B. The slider B is fixedly connected to the upper end of the hollow plate A. The slider B is threadedly connected to the lead screw B by a nut.

[0009] As a preferred embodiment of the present invention, the up-and-down moving mechanism includes a hollow mounting plate, a mounting plate and a cylinder. The mounting plate is fixedly connected to the upper end of the slider A, the cylinder is fixedly connected to the lower end of the mounting plate, the hollow mounting plate is located on the lower side of the slider A, and the extended end of the cylinder is fixed to the hollow mounting plate.

[0010] In a preferred embodiment of the present invention, the drip tube is fixedly connected to the lower end of the hollow mounting plate, and the other ends of the slurry outlet pipe and the slurry inlet pipe pass through the hollow mounting plate and are connected to the drip tube.

[0011] As a preferred embodiment of the present invention, a support plate is fixedly connected to one inner wall of the device housing, and the motor A is located at the upper end of the support plate.

[0012] Compared with the prior art, the beneficial effects of the present invention are: 1. By integrating intelligent sensing and control decision modules, the system achieves fully automated operation from blood collection, centrifugation, monitoring, separation to output, eliminating reliance on human experience. The system can automatically optimize centrifugation parameters and complete precise extraction based on the real-time characteristics and stratification of blood samples, significantly improving the standardization of operations and batch-to-batch consistency, and reducing quality fluctuations and contamination risks caused by human operation.

[0013] 2. The system employs optical layer recognition technology in conjunction with an automatic separation module to monitor changes in the liquid-liquid interface during centrifugation in real time. Closed-loop control enables precise positioning and extraction of the platelet-rich layer. Simultaneously, the introduction of a temperature-controlled centrifugation chamber and a vibration feedback system effectively reduces mechanical damage and activation to platelets during centrifugation, better preserving their biological activity and functional integrity.

[0014] 3. The device integrates a data management and human-computer interaction module, which can record key data, including blood sample parameters, centrifugation process, extraction location and output quality, throughout the entire process to form a complete preparation file. The system supports local data storage and secure transmission, which facilitates quality traceability, process analysis and compliance auditing, and provides reliable data support for clinical treatment and scientific research, which is in line with the development trend of modern medical quality management system. Attached Figure Description

[0015] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings: Figure 1 This is a front perspective view of the present invention; Figure 2 This is a sectional perspective view of the present invention; Figure 3 This is a structural diagram of the moving mechanism in this invention; Figure 4 For the present invention Figure 3 A magnified view of a section at point A in the middle; Figure 5 For the present invention Figure 3 A magnified view of a section at point B.

[0016] In the diagram: 1. Equipment casing; 2. Top cover; 3. Plasma collection equipment; 4. Mounting frame; 5. Plasma outlet tube; 6. Control core; 7. Centrifuge body; 8. Test tube mounting tray; 9. Test tube; 10. Hollow plate A; 11. Slider A; 12. Motor B; 13. Hollow plate B; 14. Lead screw B; 15. Plasma inlet tube; 16. Hollow mounting plate; 17. Dropper; 18. Motor B; 19. Support plate; 20. Lead screw A; 21. Slider B; 22. Mounting plate; 23. Cylinder; 24. LCD screen. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Example 1

[0019] Please see Figures 1-5 The present invention provides the following technical solutions: A fully intelligent platelet-rich plasma preparation device, comprising: Equipment casing 1 with an opening at the top; The upper cover plate 2 is located at the opening of the equipment housing 1; Centrifuge body 7 is located inside equipment housing 1, and the motor of centrifuge body 7 is fixed to the bottom of equipment housing 1; Test tube mounting tray 8 is located inside the centrifuge body 7; Multiple test tubes 9 are located within the test tube mounting tray 8; The slurry outlet pipe 5 and the slurry inlet pipe 15 pass through both sides of the equipment casing 1, respectively. The plasma collection device 3 is fixedly connected to one side of the device housing 1, and one end of the plasma outlet tube 5 is connected to the plasma collection device 3. Mounting bracket 4 is fixedly connected to the lower end of the upper cover plate 2; Control core 6, which is fixed to the bottom of the equipment housing 1; The drip tube 17 is located inside the equipment housing 1, and the other ends of the slurry outlet pipe 5 and the slurry inlet pipe 15 are connected to the drip tube 17. The liquid crystal display screen 24 is fixedly connected to the upper end of the upper cover plate 2; The forward and backward moving mechanism is located inside the equipment housing 1 and drives the drip tube 17 to move back and forth. The left and right moving mechanism is located above the front and back moving mechanism and drives the entire front and back moving mechanism to move left and right. The up-and-down moving mechanism is located at the upper end of the front-and-back moving mechanism and drives the dropper 17 to move up and down. The forward and backward moving mechanism includes a hollow plate A10, a motor A18, a lead screw A20, and a slider A11. The hollow plate A10 is located inside the equipment housing 1. The lead screw A20 is rotatably connected inside the hollow plate A10. The motor A18 is fixedly connected to one side of the hollow plate A10, and its output shaft passes through the hollow plate A10. One end of the lead screw A20 is fixed to the output shaft of the motor A18. The slider A11 is sleeved on the surface of the hollow plate A10, and the slider A11 is threadedly connected to the lead screw A20 through a nut thread. The left and right moving mechanism includes a motor B12, a hollow plate B13, a lead screw B14, and a slider B21. The motor B12 and the hollow plate B13 are both fixedly connected to the lower end of the mounting bracket 4. The output shaft of the motor B12 passes through the hollow plate B13. The lead screw B14 is rotatably connected to the hollow plate B13. The slider B21 is fixedly connected to the upper end of the hollow plate A10. The slider B21 is threadedly connected to the lead screw B14 through a nut. The up-and-down moving mechanism includes a hollow mounting plate 16, a mounting plate 22, and a cylinder 23. The mounting plate 22 is fixedly connected to the upper end of the slider A11, and the cylinder 23 is fixedly connected to the lower end of the mounting plate 22. The hollow mounting plate 16 is located on the lower side of the slider A11, and the extended end of the cylinder 23 is fixed to the hollow mounting plate 16. The drip tube 17 is fixedly connected to the lower end of the hollow mounting plate 16, and the other ends of the slurry outlet pipe 5 and the slurry inlet pipe 15 pass through the hollow mounting plate 16 and are connected to the drip tube 17.

[0020] In a specific embodiment of the present invention, the liquid crystal display screen 24 is used to input basic patient information (name, gender, age, ID number, consultation number, etc.) and blood analysis results (red blood cell count, white blood cell count, platelet count, etc.). The operator first uses the plasma collection device to collect the patient's plasma. The plasma is collected under the power of the blood collection pump. When the plasma collection device 3 is started, the plasma collection device 3 delivers the collected plasma to the dropper 17 through the plasma inlet pipe 15. After receiving the collection command, the control core 6 controls the forward and backward movement. The mechanism's motor A18 starts, driving the lead screw A20 to rotate. The lead screw A20 drives the slider A11 to move back and forth along the hollow plate A10. When the slider A11 moves above the target test tube 9, the control core 6 controls the cylinder 23 to start. The cylinder 23 extends, causing the hollow mounting plate 16 and the dropper 17 to descend, allowing the dropper 17 to extend into the test tube 9. After the dropper 17 is in place, plasma is injected into the test tube 9 through the dropper 17. After the test tube 9 is full, the cylinder 23 retracts, and the dropper 17 rises. The control core 6 controls the left and right movement. The motor B12 of the moving mechanism starts, driving the lead screw B14 to rotate. The lead screw B14 drives the slider B21 to move left and right along the hollow plate B13, thereby driving the forward and backward moving mechanism and the dropper 17 to move left and right to the next test tube 9. The above steps are repeated until all test tubes 9 are filled with plasma. After the blood injection is completed, the control core 6 starts the centrifuge body 7. The test tube mounting plate 8 drives the test tubes 9 to rotate at high speed to achieve platelet enrichment. After centrifugation, the control core 6 controls the dropper 17 to move above each test tube 9, descend and draw up platelet-rich plasma (PRP), and output it through the plasma outlet tube 5. The remaining plasma can be reinjected into the patient through the dropper 17 to complete the whole process of high-precision PRP preparation. The various mechanisms work together to reduce manual intervention, improve preparation efficiency and quality stability, and are suitable for large-scale clinical applications. In this device, both the plasma outlet tube 5 and the plasma inlet tube 15 can be extended at will, so that the puncture needle in the plasma collection device 3 can be stretched at will and directly contact the patient's skin, providing convenience.

[0021] Please refer to the details. Figures 2-3 A support plate 19 is fixedly connected to one inner wall of the equipment housing 1, and the motor A18 is located at the upper end of the support plate 19.

[0022] In this embodiment, the support plate 19 provides a stable mounting base for the motor A18, effectively reducing vibration transmission, ensuring the motion accuracy and reliability of the forward and backward moving mechanism, and avoiding vibration offset that may be caused by the motor being directly mounted on the inner wall of the housing.

[0023] The working principle and usage process of this invention: After the operator starts the equipment, the plasma collection device 3 begins to collect whole blood from the patient. The collected plasma is transported to the dropper 17 through the plasma outlet tube 5. After the control core 6 receives the blood collection completion signal, it controls the motor A18 in the forward and backward movement mechanism to start, driving the lead screw A20 to rotate and driving the slider A11 to move forward and backward along the hollow plate A10, so that the dropper 17 moves directly above the first test tube 9.

[0024] Once the dropper 17 is in position, the control core 6 activates the cylinder 23 in the up-down movement mechanism, pushing the hollow mounting plate 16 and the dropper 17 downwards, allowing the dropper 17 to extend into the test tube 9. After the dropper 17 enters the test tube 9, the control core 6 opens the pipeline valve, and plasma is injected into the test tube 9 through the dropper 17. After the first test tube 9 is filled, the cylinder 23 retracts, and the dropper 17 moves upwards and away from the test tube. After the dropper 17 is completely withdrawn, the control core 6 activates the motor B12 in the left-right movement mechanism, driving the lead screw B14 to rotate, which in turn drives the slider B21 to move left and right along the hollow plate B13. This, in turn, drives the front-back movement mechanism and the dropper 17 to move laterally to the next test tube 9. The above steps of descent-injection-ascent-lateral movement are repeated until all test tubes 9 have been injected with plasma. After all test tubes 9 have been injected, the control core 6 activates the centrifuge body 7, driving the test tube mounting tray 8 and the test tubes 9 at high speed. During the rotation and centrifugation process, the control core 6 adjusts parameters such as rotation speed and time according to preset or real-time feedback intelligent algorithms to achieve efficient and high-purity enrichment of platelets. After centrifugation is completed, the centrifuge automatically decelerates and stops. After the centrifuge stops, the control core 6 controls the dropper 17 to move above the first test tube 9, descend and extend into the platelet-rich layer inside the test tube. After the dropper 17 reaches the target liquid layer, the control core 6 starts negative pressure suction, transporting the platelet-rich plasma (PRP) through the dropper 17 and the plasma inlet tube 15 to the finished product collection container. The above positioning-descending-suction-ascending-lateral movement steps are repeated to complete the extraction of PRP from all test tubes 9. When the PRP extraction is completed, if the remaining plasma needs to be reinfused into the patient, the control dropper 17 is repositioned and suctioned to return the remaining plasma through the pipeline system. If reinfusion is not required, the remaining plasma is treated as medical waste and enters the closed waste liquid collection system.

[0025] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A fully intelligent platelet-rich plasma preparation device, characterized in that: include: The device housing with an opening at the top (1); The upper cover plate (2) is located at the opening of the equipment housing (1); Centrifuge body (7), the centrifuge body (7) is located inside the equipment shell (1), and the motor of the centrifuge body (7) is fixed to the bottom of the equipment shell (1); Test tube mounting tray (8), which is located inside the centrifuge body (7); Multiple test tubes (9) are located within the test tube mounting tray (8); The slurry outlet pipe (5) and the slurry inlet pipe (15) respectively penetrate both sides of the equipment casing (1); The plasma collection device (3) is fixedly connected to one side of the equipment shell (1), and one end of the plasma outlet tube (5) is connected to the plasma collection device (3); Mounting bracket (4), which is fixedly connected to the lower end of the upper cover plate (2); Control core (6), the control core (6) is fixed to the bottom of the device housing (1); The drip tube (17) is located inside the equipment housing (1), and the other end of the slurry outlet pipe (5) and the slurry inlet pipe (15) are connected to the drip tube (17); The liquid crystal display screen (24) is fixedly connected to the upper end of the upper cover plate (2); A forward and backward moving mechanism is located inside the equipment housing (1) and drives the dropper (17) to move forward and backward. A left-right moving mechanism is located at the upper end of the front-back moving mechanism, which drives the entire front-back moving mechanism to move left and right. The up-and-down moving mechanism is located at the upper end of the front-and-back moving mechanism and drives the dropper (17) to move up and down.

2. The fully intelligent platelet-rich plasma preparation device according to claim 1, characterized in that: The forward and backward moving mechanism includes a hollow plate A (10), a motor A (18), a lead screw A (20), and a slider A (11). The hollow plate A (10) is located inside the equipment housing (1). The lead screw A (20) is rotatably connected inside the hollow plate A (10). The motor A (18) is fixedly connected to one side of the hollow plate A (10), and its output shaft passes through the hollow plate A (10). One end of the lead screw A (20) is fixed to the output shaft of the motor A (18). The slider A (11) is sleeved on the surface of the hollow plate A (10). The slider A (11) is threadedly connected to the lead screw A (20) through a nut thread.

3. The fully intelligent platelet-rich plasma preparation device according to claim 2, characterized in that: The left and right moving mechanism includes a motor B (12), a hollow plate B (13), a lead screw B (14), and a slider B (21). The motor B (12) and the hollow plate B (13) are both fixedly connected to the lower end of the mounting bracket (4). The output shaft of the motor B (12) passes through the hollow plate B (13). The lead screw B (14) is rotatably connected to the hollow plate B (13). The slider B (21) is fixedly connected to the upper end of the hollow plate A (10). The slider B (21) is threadedly connected to the lead screw B (14) by a nut.

4. The fully intelligent platelet-rich plasma preparation device according to claim 3, characterized in that: The up-and-down moving mechanism includes a hollow mounting plate (16), a mounting plate (22), and a cylinder (23). The mounting plate (22) is fixedly connected to the upper end of the slider A (11), and the cylinder (23) is fixedly connected to the lower end of the mounting plate (22). The hollow mounting plate (16) is located on the lower side of the slider A (11), and the extended end of the cylinder (23) is fixed to the hollow mounting plate (16).

5. The fully intelligent platelet-rich plasma preparation device according to claim 4, characterized in that: The drip tube (17) is fixedly connected to the lower end of the hollow mounting plate (16), and the other ends of the slurry outlet pipe (5) and the slurry inlet pipe (15) pass through the hollow mounting plate (16) and are connected to the drip tube (17).

6. The fully intelligent platelet-rich plasma preparation device according to claim 5, characterized in that: A support plate (19) is fixedly connected to one side of the inner wall of the equipment housing (1), and the motor A (18) is located at the upper end of the support plate (19).

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