Automatic dosing and continuous sampling integrated device of drug dissolution tester

Abstract

The invention relates to the technical field of medicine feeding and sampling integrated devices, in particular to an automatic medicine feeding and continuous sampling integrated device of a medicine dissolution tester, which comprises a supporting part, a box body and a plurality of sample storage tubes, and further comprises a plurality of medicine dissolving parts, a stirring part, a sampling part, a cleaning part and an external hanging part, the medicine dissolving cylinder is placed in the box body, and the top of the medicine dissolving cylinder is higher than the box body; the number of the stirring parts is the same as that of the medicine dissolving parts, and the stirring parts are arranged on the supporting part, can extend into the medicine dissolving parts, are used for containing medicines needing to be dissolved and can stir solvents in the medicine dissolving parts. According to the invention, the medicine storage component is detachably integrated on the stirring part and is driven by the stirring part to rotate in the dissolution medium, so that automatic release and mixing of medicines are realized. The medicine is placed in the medicine storage cylinder and exchanges with the solvent through the through holes, so that the problem of over-high local concentration caused by traditional direct dosing is avoided, and the accuracy of data at the initial stage of dissolution is improved.

Description

Technical Field

[0001] This invention relates to the field of integrated drug dosing and sampling devices, and more particularly to an integrated automatic drug dosing and continuous sampling device for a drug dissolution tester. Background Technology

[0002] Dissolution testing is a core in vitro assay method for evaluating the rate and extent of dissolution of active ingredients in oral solid dosage forms under specific conditions. Its results are crucial for drug quality control, bioequivalence evaluation, and formulation process research. A standard dissolution test typically involves injecting a specified volume of dissolution medium into a thermostatic dissolution vessel, adding the test sample, stirring at a preset speed, and taking samples at regular intervals. The drug concentration in the sample is then analyzed.

[0003] Currently, while the dosing and sampling steps of dissolution testing have been partially automated, problems remain, including cumbersome operation, high risk of cross-contamination, and poor test continuity. Specifically, the dosing step often involves manual or semi-automatic robotic arms directly adding the sample into the dissolution vessel. At the moment of addition, the sample concentration may be too high locally, affecting the accuracy of the initial dissolution curve. The sampling step relies heavily on multi-channel peristaltic pumps and sampling needles to switch between different dissolution vessels to extract samples. When changing sampling points, residual sample solution from the previous sampling can remain in the sampling needle tubing, causing trace contamination for subsequent samplings and affecting the accuracy and reliability of multiple, continuous sampling data. Furthermore, the overall experimental setup is loosely structured, with multiple functional units such as dosing, stirring, sampling, and cleaning operating relatively independently, resulting in a large footprint, complex operating procedures, and low levels of automation integration. Summary of the Invention

[0004] The main objective of this invention is to provide an integrated automatic drug dosing and continuous sampling device for a drug dissolution tester, in order to solve the problems raised in related technologies.

[0005] To achieve the above objectives, according to one aspect of the present invention, an integrated automatic drug dispensing and continuous sampling device for a drug dissolution tester is provided, comprising a support, a housing, and a plurality of sample storage tubes, and further comprising: The dissolving section comprises several parts, each including a dissolving cylinder and a bottom sealing section. The dissolving cylinder is placed inside the box and its top is higher than the box, and is used to hold the solvent. The bottom sealing section is detachably provided on the dissolving cylinder and is used to isolate the solvent inside the dissolving cylinder from the outside. The number of stirring sections is the same as that of the dissolving sections, both of which are located on the support section and can extend into the dissolving section. They are used to hold the drugs to be dissolved and to stir the solvent in the dissolving section. The number of sampling sections is the same as that of the drug dissolving sections, and they are all located on the support section. They are used to sample the solution in the drug dissolving section and put it into the corresponding sample storage tube. The number of cleaning sections is the same as that of the dissolving sections, and they are all located on the box body for cleaning the sampling section; The number of external attachments is the same as that of the cleaning units, and they are all fixedly installed on the side wall of the box for holding the cleaning units and sample storage tubes.

[0006] Furthermore, the support includes a base frame, a top frame, a bottom support plate, and a top support plate. The base frame is fixedly connected to the housing, the bottom support plate is fixedly mounted on the top of the base frame, the top frame is fixedly mounted above the bottom support plate, and the top support plate is fixedly mounted above the top frame.

[0007] Furthermore, a number of protrusions are fixedly provided above the outer ring of the dissolving cartridge, a receiving ring is provided at the lower end of the outer ring, a number of support legs are fixedly provided below the receiving ring, the support legs are fixedly connected to the bottom wall of the box, and the dissolving cartridge is inserted into the receiving ring.

[0008] Furthermore, the bottom seal includes a dissolving cap, a circular groove is provided above the center of the dissolving cap, a through-hole is provided in the middle, an annular platform is provided between the circular groove and the through-hole, a number of protruding ridges are fixedly provided on the top surface of the annular platform, and the annular platform is rotatably connected to the dissolving cap; the dissolving cap is also provided with a pinhole, a number of fan-shaped plugs are provided in the pinhole, and the arc-shaped plugs are fixedly connected to the dissolving cap.

[0009] Furthermore, the stirring part includes a drug storage component, a sealing part, and a driving part. The driving part includes a micro motor and a first electric cylinder. The piston rod of the first electric cylinder is fixedly connected to the micro motor. A vertical rod is fixedly provided on the output shaft of the micro motor. The bottom end of the vertical rod is connected to the sealing part, and the bottom of the sealing part is connected to the drug storage component.

[0010] Furthermore, the sealing part includes an annular cover, the bottom of which is fixedly provided with a protruding ring, and the lower surface of the annular cover is provided with several grooves.

[0011] Furthermore, the medicine storage assembly includes a stirring rod and a medicine storage cylinder. A concave ring is fixedly provided at the top of the medicine storage cylinder, and the concave ring is threadedly connected to the bottom end of the stirring rod. Several through holes are opened on the outer ring of the upper end of the medicine storage cylinder.

[0012] Furthermore, the cleaning unit includes a cleaning pipe and a cleaning assembly. The cleaning pipe has several guide grooves inside. The cleaning assembly includes an inner cylinder with several bristles fixed inside and several support plates fixed outside. Several support rings are fixed between the support plates, and the support plates are slidably connected to the guide grooves.

[0013] Furthermore, the sampling unit includes a temporary storage cylinder, the bottom of which is fixedly provided with a needle for extracting the drug solution, and the upper side of which is fixedly provided with an air extraction tube and a water injection tube.

[0014] Furthermore, the external attachment includes an upper hoop and a lower support ring. The upper hoop includes an upper inner hoop and an upper outer hoop, and the lower support ring includes a lower inner support ring and a lower outer support ring. The inner end of the upper inner hoop is fixedly connected to the housing, and the outer end is fixedly connected to the upper outer hoop. The inner end of the lower inner support ring is fixedly connected to the housing, and the outer end is fixedly connected to the lower outer support ring.

[0015] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention achieves automatic drug release and mixing by detachably integrating the drug storage component into the stirring unit, which drives the component to rotate in the dissolution medium. The drug is placed in the storage cylinder and exchanges with the solvent through the through-hole, avoiding the problem of excessively high local concentrations caused by traditional direct drug dosing and improving the accuracy of initial dissolution data.

[0016] 2. This invention achieves in-situ, closed-loop cleaning of the sampling needle by incorporating a sampling section with an independent suction chamber in the temporary storage tube, along with a dedicated cleaning section. After each sampling, the sampling needle can be immediately moved into the cleaning tube, where the outer wall is cleaned by brushes, and the inner wall is repeatedly cleaned by a diaphragm pump-driven suction of cleaning fluid within the temporary storage tube. This design ensures the use of clean sampling tubing for each sampling, completely avoiding cross-contamination between samples from different time points and guaranteeing the absolute reliability and accuracy of data from multiple consecutive samplings.

[0017] 3. This invention creatively integrates the dissolving unit, the stirring unit with dosing function, the sampling unit, the cleaning unit, and the sample storage tube through a support unit and a housing, forming a compact, integrated device. Each functional module has a fixed position and works collaboratively, resulting in a high degree of automation, simplified operation procedures, reduced manual intervention, and improved overall efficiency and standardization of dissolution testing. Attached Figure Description

[0018] Figure 1 This is an overall schematic diagram of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention. Figure 2 This is a cross-sectional view of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention; Figure 3 This is a schematic diagram of the external attachment structure of the automatic drug dispensing and continuous sampling integrated device of the drug dissolution tester of the present invention. Figure 4 This is a schematic diagram of the dissolving section of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention. Figure 5 This is a schematic diagram of the stirring section of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention. Figure 6This is a schematic diagram of the sealing part of the automatic drug dispensing and continuous sampling integrated device of the drug dissolution tester of the present invention; Figure 7 This is a partially enlarged schematic diagram of the integrated automatic drug dosing and continuous sampling device of the drug dissolution tester of the present invention. Figure 1 ; Figure 8 This is a partially enlarged schematic diagram of the integrated automatic drug dosing and continuous sampling device of the drug dissolution tester of the present invention. Figure 2 ; Figure 9 This is a cross-sectional view of the cleaning section of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention. Figure 10 This is a schematic diagram of the sampling section of the integrated automatic drug dispensing and continuous sampling device of the drug dissolution tester of the present invention.

[0019] Figure label: 1. Support unit; 11. Base frame; 12. Top frame; 13. Bottom support plate; 14. Top support plate; 2. Box body; 21. Round hole; 22. Slot; 3. Dissolving section; 31. Dissolving cartridge; 32. Bottom seal; 33. Protrusion; 34. Receptacle ring; 35. Support leg; 321. Dissolving cap; 322. Circular groove; 323. Receptacle hole; 324. Raised ridge; 325. Pinhole; 326. Fan-shaped plug; 327. Ring platform; 4. External mounting part; 41. Upper inner hoop ring; 42. Lower inner support ring; 43. Upper outer hoop ring; 44. Lower outer support ring; 5. Stirring section; 51. Medicine storage assembly; 52. Sealing section; 53. Vertical rod; 54. Micro motor; 55. First electric cylinder; 511. Stirring rod; 512. Medicine storage cylinder; 513. Concave ring; 514. Through hole; 521. Annular cover; 522. Groove; 523. Protruding ring; 6. Sampling section; 61. Slide rail; 62. Slider; 63. Second electric cylinder; 64. Temporary storage cylinder; 65. Air extraction pipe; 66. First diaphragm pump; 67. Water injection pipe; 68. Second diaphragm pump; 69. Needle; 7. Cleaning section; 71. Cleaning pipe; 72. Ring cover; 73. Inner cylinder; 74. Support plate; 75. Support ring; 76. Guide groove; 77. Brush bristles; 78. Drain pipe; 8. Sample storage tubes. Detailed Implementation

[0020] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with the accompanying drawings and preferred embodiments, is provided below.

[0021] This embodiment provides an integrated device for automatic drug dosing and continuous sampling in a drug dissolution tester, such as... Figure 1 and 2 As shown, it includes a support unit 1, a box body 2, a dissolving unit 3, an external attachment unit 4, a stirring unit 5, a sampling unit 6, a cleaning unit 7, and several sample storage tubes 8.

[0022] The support unit 1 includes a base frame 11, a top frame 12, a bottom support plate 13, and a top support plate 14. The base frame 11 is fixedly connected to the housing 2, providing stable bottom support. The bottom support plate 13 is fixedly mounted on top of the base frame 11, while the top frame 12 is fixedly mounted above the bottom support plate 13. The top support plate 14 is fixedly mounted above the top frame 12. Both the base frame 11 and the top frame 12 are L-shaped, with their horizontal sections used to stably support the bottom support plate 13 and the top support plate 14, respectively. This layered frame structure provides a precise positioning base and sufficient operating space for the subsequent installation and movement of various components.

[0023] The top surface of the housing 2 has several circular holes 21 for placing the dissolving unit 3. In order to fix the dissolving cylinder 31, several radially arranged slots 22 are also provided on the outer ring of each circular hole 21.

[0024] The dissolving section 3 is a container for holding the dissolving medium, and its number can be set according to the number of test channels. Each dissolving section 3 includes a dissolving cartridge 31 and a bottom seal 32. The dissolving cartridge 31 is placed inside the circular hole 21 of the housing 2, and its top is higher than the top surface of the housing 2 for easy operation. Figure 4 As shown, several protrusions 33 are fixedly provided above the outer ring of the dissolving cartridge 31, corresponding one-to-one with the slots 22 on the box body 2. The protrusions 33 can be inserted into the corresponding slots 22, which can effectively prevent the dissolving cartridge 31 from rotating during the test. A receiving ring 34 is fitted at the lower end of the outer ring of the dissolving cartridge 31. The receiving ring 34 is firmly connected to the bottom wall of the box body 2 through several legs 35 fixed below it, thereby suspending and stably fixing the dissolving cartridge 31 inside the box body 2.

[0025] The bottom seal 32 is used to seal the opening of the dissolving cartridge 31, isolating its internal environment from the outside. For example... Figure 8 As shown, the bottom seal 32 includes a dissolving cap 321 that is detachably screwed onto the bottom of the dissolving cartridge 31. A circular groove 322 is formed above the center of the dissolving cap 321, with a through-hole 323 in the center. An annular platform 327 is provided between the circular groove 322 and the through-hole 323. Several protruding ribs 324 are fixedly provided on the top surface of the annular platform 327, and the annular platform 327 is rotatably connected to the main body of the dissolving cap 321. Furthermore, a pinhole 325 for sampling is also provided on the dissolving cap 321. Several elastic fan-shaped plugs 326 are provided inside the pinhole 325. The arc-shaped edges of the fan-shaped plugs 326 are fixedly connected to the dissolving cap 321, and their free ends are closed in their natural state to seal the pinhole 325. When compressed, they can deform to allow passage.

[0026] The number of stirring units 5 is the same as that of the dissolving units 3, and they are mounted on the support unit 1. Each stirring unit 5 includes a drug storage assembly 51, a sealing unit 52, and a driving unit.

[0027] like Figure 5 As shown, the drive unit includes a first electric cylinder 55 and a micro motor 54. The cylinder body of the first electric cylinder 55 is fixedly mounted on the top of the top support plate 14, and its piston rod extends vertically downward through the top support plate 14 and can slide up and down. The micro motor 54 is fixedly mounted on the end of the piston rod of the first electric cylinder 55. The output axis of the micro motor 54 is downward and is fixedly connected to a vertical rod 53, which extends downward through the bottom support plate 13 and is slidably connected to the bottom support plate 13.

[0028] The sealing part 52 is fixedly connected to the bottom end of the vertical rod 53. For example... Figure 6 As shown, the sealing part 52 includes an annular cover 521, which is fixedly connected to the bottom end of the vertical rod 53. The lower surface of the annular cover 521 has several grooves 522, and a raised ring 523 is fixedly provided at the bottom. The annular cover 521 is fixedly connected to the vertical rod 53.

[0029] The drug storage component 51 is connected below the sealing part 52. For example... Figure 7 As shown, the drug storage assembly 51 includes a stirring rod 511 and a storage cylinder 512. The upper end of the stirring rod 511 is fixedly connected to an annular cover 521, and the lower end is provided with an internal thread. The top of the storage cylinder 512 is fixedly provided with a concave ring 513 with an external thread, which is detachably installed at the bottom end of the stirring rod 511 through a threaded connection. Several through holes 514 are opened on the upper end of the side wall of the storage cylinder 512 for the entry and exit of the dissolution medium. The storage cylinder 512 is used to hold the drug tablets or powder to be tested.

[0030] During operation, the first electric cylinder 55 drives the entire stirring section 5 to descend. When the storage cylinder 512 reaches the preset depth inside the dissolving cylinder 31, and the protruding ring 523 of the sealing part 52 is inserted into the receiving hole 323 of the dissolving cover 321, the bottom surface of the annular cover 521 is pressed against the ring platform 327, and the protruding ridge 324 is embedded in the groove 522, the micro motor 54 is precisely against the upper surface of the bottom support plate 13, forming a stable working position. At this time, the sealing part 52 and the bottom sealing part 32 are tightly fitted, sealing the gap at the receiving hole 323 and ensuring the airtightness of the inside of the dissolving cylinder 31. When the micro motor 54 is started, the power is transmitted to the storage cylinder 512 through the vertical rod 53, the sealing part 52, and the stirring rod 511, causing it to rotate. The dissolving medium enters the storage cylinder 512 through the through hole 514 to dissolve the medicine, and the dissolved medicine then diffuses through the through hole 514 to the entire dissolving cylinder 31, realizing a gentle and uniform drug dosing and stirring process. Since the ring platform 327 can rotate relative to the dissolving cap 321, the rotation of the stirring part is not hindered by the bottom seal 32.

[0031] The number of sampling sections 6 also corresponds to the number of dissolving sections 3. For example... Figure 10 As shown, each sampling unit 6 includes a temporary storage cylinder 64. A needle 69 for extracting solution is fixedly mounted on the bottom of the temporary storage cylinder 64, and an air extraction pipe 65 and a water injection pipe 67 are fixedly connected to its upper side, both equipped with miniature valves. The air extraction pipe 65 is connected to a first diaphragm pump 66 via a flexible hose, and the water injection pipe 67 is connected to a second diaphragm pump 68 via a flexible hose. The piston rod of a second electric cylinder 63 is fixedly mounted on the top of the temporary storage cylinder 64, driving its up-and-down movement. A slider 62 is fixedly mounted on the top of the second electric cylinder 63. A slide rail 61 is fixedly mounted on the bottom of the base plate 13, and the slider 62 slides in conjunction with the slide rail 61. A third electric cylinder (not shown separately in the figure) is also mounted on one end of the slide rail 61, and the piston rod of the third electric cylinder is connected to the slider 62, driving the entire sampling unit 6 to move horizontally along the slide rail 61.

[0032] During sampling, the third electric cylinder drives the slider 62 to move, positioning the needle 69 directly above the needle hole 325 of the dissolving cartridge 31. Then, the second electric cylinder 63 pushes the temporary storage cartridge 64 down, and the needle 69 pierces and pushes open the fan-shaped plug 326 to enter below the liquid surface of the dissolving cartridge 31. The water injection pipe 67 valve is closed, the vacuum pipe 65 valve is opened, and the first diaphragm pump 66 is started to put it into suction mode, creating a vacuum in the temporary storage cartridge 64. The solution is drawn into the temporary storage cartridge 64 under negative pressure. After sampling is completed, the second electric cylinder 63 retracts, the needle 69 is pulled out, and the fan-shaped plug 326 automatically resets to seal the needle hole 325. Subsequently, the third electric cylinder moves the needle 69 above the corresponding sample storage tube 8, and the first diaphragm pump 66 is switched to exhaust mode to discharge the sample solution in the temporary storage cartridge 64 into the sample storage tube 8.

[0033] The number of cleaning sections 7 is the same as the number of channels, and they are installed on the side wall of housing 2. For example... Figure 9 As shown, each cleaning unit 7 includes a vertical cleaning tube 71 and a cleaning assembly. The inner wall of the cleaning tube 71 has several longitudinal guide grooves 76, and its top is threadedly connected to a ring cap 72, while its bottom is connected to a drain pipe 78 with a micro-valve. The cleaning assembly includes an inner cylinder 73, inside which are fixed numerous bristles 77 for brushing the outer wall of the needle 69; externally, several support plates 74 are fixedly attached, slidingly engaging with the guide grooves 76, and the support plates 74 are reinforced by several support rings 75. The entire cleaning assembly can be removed by unscrewing the ring cap 72 for easy replacement or cleaning. The cleaning unit 7 is used to clean the needle 69 and the interior of the temporary storage cylinder 64 of the sampling unit 6 after each sampling to prevent cross-contamination.

[0034] After sampling and transferring the sample to the storage tube 8, the third electric cylinder moves the needle 69 directly above the cleaning tube 71. The second electric cylinder 63 drives the needle 69 down and inserts it into the inner cylinder 73, where the brush 77 cleans any residual droplets on the outer wall of the needle 69. Then, the suction pipe valve 65 is closed, the water injection pipe valve 67 is opened, and the second diaphragm pump 68 is started. The second diaphragm pump 68 first draws in air, drawing the pre-placed cleaning solution in the cleaning tube 71 into the temporary storage cylinder 64 through the needle 69; then it switches to exhaust air, discharging the cleaning solution. This suction and exhaust process is repeated several times to thoroughly clean the inner walls of the temporary storage cylinder 64 and the needle 69. The cleaning waste liquid is finally discharged from the drain pipe 78.

[0035] The volume of the temporary storage cylinder (64) is greater than the volume of the solution during one sampling to prevent the solution from entering the suction pipe 65 from the temporary storage cylinder (64), which would result in residual drugs in the suction pipe 65.

[0036] The external mounting part 4 is fixedly installed on the side wall of the box body 2, for the orderly placement of the cleaning part 7 and the sample storage tube 8. For example... Figure 3 As shown, the external mounting part 4 includes an upper inner clamping ring 41 and a lower inner support ring 42 for fixing the cleaning tube 71, and an upper outer clamping ring 43 and a lower outer support ring 44 for fixing the sample storage tube 8. The lower inner support ring 42 is located directly below the upper inner clamping ring 41, and the lower outer support ring 44 is located directly below the upper outer clamping ring 43. The inner diameter of the upper inner clamping ring 41 is slightly larger than the outer diameter of the cleaning tube 71, facilitating the insertion of the cleaning tube 71; the inner diameter of the lower inner support ring 42 is smaller than the outer diameter of the cleaning tube 71, serving to support the cleaning tube 71. The inner diameter of the upper outer clamping ring 43 is slightly larger than the outer diameter of the sample storage tube 8, facilitating the insertion of the sample storage tube 8; the inner diameter of the lower outer support ring 44 is smaller than the outer diameter of the sample storage tube 8, serving to support the sample storage tube 8, making the overall layout of the device compact and neat.

[0037] The working process of the device of this invention is briefly described as follows: First, the dissolution medium is injected into each dissolution cylinder 31 and the bottom seal 32 is installed. The weighed medicine is loaded into the storage cylinder 512 and tightened onto the stirring rod 511. By controlling the first electric cylinder 55, the storage component 51 is lowered into the dissolution cylinder 31 and sealed, and the micro motor 54 is started to perform drug addition and stirring. When the preset sampling time point is reached, the sampling unit 6 completes a series of actions such as sampling, transferring the sample to the storage tube 8, and cleaning the needle and tubing in situ. The entire process is highly automated, with each channel operating independently without interference, which greatly improves the accuracy, repeatability, and work efficiency of the dissolution test.

[0038] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. An integrated automatic drug dispensing and continuous sampling device for a drug dissolution tester, comprising a support (1), a housing (2), and several sample storage tubes (8), characterized in that, Also includes: The dissolving section (3) has several parts, each including a dissolving cylinder (31) and a bottom sealing section (32). The dissolving cylinder (31) is placed inside the box (2) and its top is higher than the box (2) for holding solvent. The bottom sealing section (32) is detachably provided on the dissolving cylinder (31) for separating the solvent in the dissolving cylinder (31) from the outside. The number of stirring parts (5) is the same as that of the dissolving parts (3), both are provided on the support part (1), and can extend into the dissolving parts (3) to hold the medicine to be dissolved and to stir the solvent in the dissolving parts (3); The number of sampling sections (6) is the same as that of the dissolving section (3), and they are all located on the support section (1). They are used to sample the solution in the dissolving section (3) and put it into the corresponding sample storage tube (8). The number of cleaning sections (7) is the same as that of the dissolving section (3), and they are all located on the box body (2) for cleaning the sampling section (6). The number of external attachments (4) is the same as that of the cleaning parts (7), and they are all fixedly installed on the side wall of the box (2) for holding the cleaning parts (7) and the sample storage tubes (8).

2. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The support part (1) includes a base frame (11), a top frame (12), a bottom support plate (13) and a top support plate (14). The base frame (11) is fixedly connected to the box body (2). The bottom support plate (13) is fixedly installed on the top of the base frame (11). The top frame (12) is fixedly installed above the bottom support plate (13). The top support plate (14) is fixedly installed above the top frame (12).

3. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The outer ring of the dissolving cylinder (31) is fixedly provided with several protrusions (33), and the lower end of the outer ring is provided with a receiving ring (34). Several support legs (35) are fixedly provided below the receiving ring (34). The support legs (35) are fixedly connected to the bottom wall of the box (2). The dissolving cylinder (31) is inserted into the receiving ring (34).

4. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The bottom seal (32) includes a dissolving cap (321). A circular groove (322) is provided above the middle of the dissolving cap (321), and a through hole (323) is provided in the middle. An annular platform (327) is provided between the circular groove (322) and the through hole (323). Several protruding ridges (324) are fixedly provided on the top surface of the annular platform (327). The annular platform (327) is rotatably connected to the dissolving cap (321). A pinhole (325) is also provided on the dissolving cap (321). Several fan-shaped plugs (326) are provided in the pinhole (325). The arc-shaped edge of the fan-shaped plug (326) is fixedly connected to the dissolving cap (321).

5. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The stirring part (5) includes a drug storage component (51), a sealing part (52) and a driving part. The driving part includes a micro motor (54) and a first electric cylinder (55). The piston rod of the first electric cylinder (55) is fixedly connected to the micro motor (54). A vertical rod (53) is fixedly provided on the output shaft of the micro motor (54). The bottom end of the vertical rod (53) is connected to the sealing part (52). The bottom of the sealing part (52) is connected to the drug storage component (51).

6. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 5, characterized in that, The sealing part (52) includes an annular cover (521), the bottom of the annular cover (521) is fixedly provided with a protruding ring (523), and the lower surface of the annular cover (521) is provided with a plurality of grooves (522).

7. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 5, characterized in that, The medicine storage component (51) includes a stirring rod (511) and a medicine storage cylinder (512). A concave ring (513) is fixedly provided on the top of the medicine storage cylinder (512), and the concave ring (513) is threadedly connected to the bottom end of the stirring rod (511). Several through holes (514) are opened on the outer ring of the upper end of the medicine storage cylinder (512).

8. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The cleaning unit (7) includes a cleaning pipe (71) and a cleaning assembly. The cleaning pipe (71) has several guide grooves (76) inside. The cleaning assembly includes an inner cylinder (73). Several brush bristles (77) are fixedly arranged inside the inner cylinder (73), and several support plates (74) are fixedly arranged outside. Several support rings (75) are fixedly arranged between the support plates (74). The support plates (74) are slidably connected to the guide grooves (76).

9. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The sampling unit (6) includes a temporary storage tube (64), with a needle (69) for extracting drug solution fixed at the bottom of the temporary storage tube (64), and an air extraction tube (65) and a water injection tube (67) fixed on the upper side.

10. The integrated automatic drug dosing and continuous sampling device for the drug dissolution tester according to claim 1, characterized in that, The external attachment (4) includes an upper hoop and a lower support ring. The upper hoop includes an upper inner hoop (41) and an upper outer hoop (43). The lower support ring includes a lower inner support ring (42) and a lower outer support ring (44). The inner end of the upper inner hoop (41) is fixedly connected to the housing (2), and the outer end is fixedly connected to the upper outer hoop (43). The inner end of the lower inner support ring (42) is fixedly connected to the housing (2), and the outer end is fixedly connected to the lower outer support ring (44).

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