Antioxidant capsule, atomized liquid and atomization device
By using antioxidant capsules in electronic atomization devices, utilizing microporous structures and slow-release mechanisms, the problems of color darkening and flavor impact caused by oxidation reactions in atomized liquids are solved, achieving long-term stability of antioxidant effects and flavor preservation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HG INNOVATION LTD
- Filing Date
- 2026-02-12
- Publication Date
- 2026-04-17
AI Technical Summary
The atomizing liquid in electronic atomizing devices darkens in color due to oxidation reactions induced by oxygen, light, and heat, affecting its appearance and perceived quality. Existing antioxidants are easily consumed prematurely in the atomizing matrix, making it difficult to cover a long shelf life and affecting the flavor.
The product uses antioxidant capsules with micropores in the outer shell. The antioxidant is slowly released in water and/or glycerol and/or propylene glycol at a rate of 0.5~20 μg·mL⁻¹·day⁻¹, achieving zero-order or near-Higuchi-type release through a permeation-diffusion/swelling-diffusion mechanism.
It significantly reduces the impact on the flavor of the atomizing matrix, solves the problem of excessive antioxidant in the early stage and insufficient antioxidant in the later stage, prolongs the antioxidant effect, and maintains the appearance and flavor stability of the atomized liquid.
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Abstract
Description
Technical Field
[0001] This application belongs to the field of electronic atomization technology, specifically relating to an antioxidant capsule, an atomizing liquid, and an atomization device. Background Technology
[0002] The atomized liquid in electronic atomizing devices is prone to oxidation reactions induced by oxygen, light, and heat, causing its color to darken, affecting its appearance and perceived quality, and accompanied by flavor shift.
[0003] To address the aforementioned technical issues, a common practice is to add antioxidants to the atomizing matrix. However, this approach has the following drawbacks: the antioxidants are consumed prematurely during the initial production / filling stages, making it difficult to cover a long shelf life. Furthermore, antioxidants have limited compatibility with complex flavor systems, which can easily affect the flavor profile. Summary of the Invention
[0004] This application aims to provide an antioxidant capsule, an atomizing liquid, and an atomizing device to solve the problem that in the technical solution of directly adding antioxidants to the atomizing matrix to inhibit the oxidation of the atomizing matrix, the antioxidants are easily consumed prematurely and it is difficult to cover the long shelf life.
[0005] To address the aforementioned technical problems, this application provides an antioxidant capsule comprising: a capsule shell and an antioxidant; wherein the antioxidant is stored inside the capsule shell; the capsule shell has permeable micropores; when the antioxidant capsule is placed in water and / or glycerol and / or propylene glycol, the antioxidant in the antioxidant capsule can be released into the water and / or glycerol and / or propylene glycol through the micropores of the capsule shell, wherein the release rate of the antioxidant in the antioxidant capsule is 0.5~20 μg·mL for at least two weeks from the time of placement in water and / or glycerol and / or propylene glycol. - ¹·day - ¹.
[0006] In some embodiments, the capsule shell is a polymer film; wherein the polymer film is made of at least one of the following materials: a crosslinked product of chitosan and sodium alginate, chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, or an ethyl cellulose composite; and / or, the pore size of the micropores is 0.05 μm to 5 μm; and / or, the thickness of the capsule shell is 10 μm to 200 μm.
[0007] In some embodiments, the antioxidant includes at least one of the following: a complex of chlorogenic acid and a co-antioxidant, chlorogenic acid, butylated hydroxyanisole, and butylated hydroxytoluene.
[0008] In some embodiments, at least one of the following is satisfied: the ethyl cellulose complex includes at least one of the following: a complex of ethyl cellulose and polyvinylpyrrolidone, or a complex of ethyl cellulose and hydroxypropyl methylcellulose; the antioxidant includes at least one of the following: propyl gallate or ascorbate palmitate.
[0009] In some embodiments, the antioxidant accounts for 10 wt% to 70 wt% of the weight of the antioxidant capsule.
[0010] This application also provides an atomizing liquid comprising water and / or glycerin and / or propylene glycol, and further comprising the antioxidant capsules described in any of the above embodiments.
[0011] This application also provides an atomizing device, including the antioxidant capsules described in any of the above embodiments.
[0012] In some embodiments, the atomizing device includes at least one single-capsule form of the antioxidant capsule; and / or, the atomizing device includes a plurality of microcapsule forms of the antioxidant capsule, and the atomizing device further includes a carrier on which the microcapsule forms of the antioxidant capsule are fixed.
[0013] In some embodiments, at least one of the following is satisfied: the particle size of the single-capsule antioxidant capsule is 0.2 mm to 5 mm; the particle size of the microcapsule antioxidant capsule is 50 μm to 500 μm; and the carrier is a polymer material.
[0014] In some embodiments, the atomizing device includes: a reservoir for storing an atomizing matrix comprising water and / or glycerol and / or propylene glycol, an atomizing core, and a liquid guide; the liquid guide transfers the atomizing matrix in the reservoir to the atomizing core; and the antioxidant capsule is disposed within the reservoir or the liquid guide.
[0015] In some embodiments, the antioxidant content in the antioxidant capsule is 0.05wt% to 2.0wt% of the amount of the atomizing matrix, and / or, the antioxidant capsule is disposed in the reservoir in at least one of the following locations: the inner wall of the reservoir, or the interior of the reservoir.
[0016] This application protects an antioxidant capsule comprising: a capsule shell and an antioxidant; wherein the antioxidant is stored inside the capsule shell; the capsule shell has permeable micropores; when the antioxidant capsule is placed in water and / or glycerol and / or propylene glycol, the antioxidant in the antioxidant capsule can be released into the water and / or glycerol and / or propylene glycol through the micropores of the capsule shell at a release rate of 0.5~20 μg·mL. - ¹·day -¹. This antioxidant capsule physically isolates the antioxidant from the atomization matrix, significantly reducing its impact on the flavor of the atomization matrix. Furthermore, due to the microporous structure of the capsule's outer shell, the release rate of the antioxidant can be adjusted to 0.5–20 μg / mL. - ¹·day - ¹, thereby solving the problem of excessive antioxidants in the early stage and insufficient antioxidants in the later stage in the background.
[0017] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Detailed Implementation
[0018] The embodiments of this application will be described in detail below. These embodiments are exemplary and are only used to explain this application, and should not be construed as limiting this application. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of this application.
[0019] The terms "first" and "second" in the specification and claims of this application may explicitly or implicitly include one or more of the features. In the description of this application, unless otherwise stated, "multiple" means two or more. Furthermore, "and / or" in the specification and claims indicates at least one of the connected objects, and the character " / " generally indicates that the preceding and following objects are in an "or" relationship.
[0020] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0021] Currently, the common approach to addressing the issue of color changes from light to dark in e-liquids due to oxidation induced by oxygen, light, and heat, affecting appearance and perceived quality, is to add antioxidants to the e-liquid matrix. However, this approach has the following problems: the effectiveness is consumed prematurely in the initial packaging stage, leading to excessive initial dosage and insufficient later dosage. Furthermore, antioxidants have limited compatibility with complex flavor systems, which can easily affect flavor.
[0022] To address the aforementioned technical problems, this application provides an antioxidant capsule comprising: a capsule shell and an antioxidant; wherein the antioxidant is stored inside the capsule shell; the capsule shell has permeable micropores; when the antioxidant capsule is placed in water and / or glycerol and / or propylene glycol, the antioxidant in the antioxidant capsule can be released into the water and / or glycerol and / or propylene glycol through the micropores of the capsule shell, wherein the release rate of the antioxidant in the antioxidant capsule is 0.5~20 μg·mL for at least two weeks from the time of placement in water and / or glycerol and / or propylene glycol. - ¹·day - ¹.
[0023] Among them, 0.5~20 μg·mL - ¹·day - ¹ indicates the amount of antioxidant released per day in 1 mL of atomized matrix from an antioxidant capsule.
[0024] This antioxidant capsule physically isolates the antioxidant from the atomization matrix, significantly reducing its impact on the flavor of the atomization matrix. Furthermore, due to the microporous structure of the capsule's outer shell, the release rate of the antioxidant can be adjusted from 0.5 to 20 μg / mL. - ¹·day - ¹, thereby solving the problem of excessive antioxidants in the early stage and insufficient antioxidants in the later stage in the background.
[0025] In some embodiments, the antioxidant within the capsule can achieve zero-order release or near-Higuchi-type release in an atomized liquid environment with glycerol and / or propylene glycol and / or water as the main solvents via a permeation-diffusion / swelling-diffusion mechanism. The physical essence is that glycerol and / or propylene glycol and / or water enter the pre-designed micropores of the outer shell, dissolve the antioxidant, and then diffuse out due to resistance.
[0026] Among them, near-Higuchi type sustained release refers to the release rate and cumulative release amount of antioxidants having characteristics close to the ideal Higuchi model; zero-order sustained release refers to the release of antioxidants at a constant rate in the atomized matrix, which is usually unaffected by time changes.
[0027] The formula for the ideal Higuchi model is as follows: ; Kh= ; Where Q represents the cumulative release amount; t represents time; Kh represents the Higuchi constant, the larger the Kh, the faster the drug release, and its value is related to drug solubility, skeleton porosity, diffusion coefficient, etc.; D represents the diffusion coefficient; p represents porosity; and τ represents the tortuosity factor.
[0028] In one embodiment, the pore size of the micropores is 0.05 μm to 5 μm.
[0029] The micropore size of the membrane needs to ensure that the antioxidant molecules can diffuse out after the antioxidant capsule begins to dissolve; at the same time, it also needs to ensure the release rate of the antioxidant molecules—neither too slow nor instantaneous. Therefore, the micropore size of the membrane is 0.05 μm to 5 μm.
[0030] Specifically, the pore size of the thin film micropores is 0.05μm, 0.5μm, 1μm, 3μm, 5μm or any value within the above range.
[0031] In one embodiment, the thickness of the capsule shell is 10 μm to 200 μm.
[0032] The thickness of the capsule shell needs to ensure sufficient structural strength to prevent the antioxidant capsule from easily breaking during filling or transportation, and also needs to ensure the diffusion path length of the antioxidant molecules, thereby ensuring the release rate of the oxidant molecules meets the concentration required by the atomization matrix. Therefore, the thickness of the capsule shell is 10μm~200μm.
[0033] Specifically, the thickness of the capsule shell is 10μm, 50μm, 100μm, 150μm, 200μm or any value within the above range.
[0034] In one embodiment, the capsule shell is a polymer film, and the polymer film is made of at least one of the following materials: a crosslinked product of chitosan and sodium alginate, chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, or an ethyl cellulose composite. The ethyl cellulose composite includes at least one of the following: a composite of ethyl cellulose and polyvinylpyrrolidone, or a composite of ethyl cellulose and hydroxypropyl methylcellulose.
[0035] Cross-linked compounds of chitosan and sodium alginate, as well as chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, and ethyl cellulose complexes, all exhibit good biocompatibility, oil-water permeability balance, and film-forming properties, making them suitable as shell materials for antioxidant capsules. In particular, complexes of ethyl cellulose and polyvinylpyrrolidone, and complexes of ethyl cellulose and hydroxypropyl methylcellulose, can also act as pore-forming agents during volatilization, facilitating the formation of more complex and interconnected microporous networks in the capsule shell.
[0036] In some embodiments, the capsule shell is a polymer film. In this embodiment, since the polymer film is a semi-permeable / slow-dissolving membrane, the drug cannot be released directly. Instead, it needs to diffuse through the micropores of the polymer film (water first penetrates into the membrane to dissolve the drug, and then the drug molecules are slowly released through the micropores) or slowly dissolve in the polymer film (the polymer gradually dissolves over time, the membrane barrier gradually disappears, and the drug is continuously released), replacing the rapid dissolution and release of ordinary capsules. This achieves "slow release" from the source, and the release rate can be precisely controlled by adjusting the thickness and component ratio of the film.
[0037] In some embodiments, the polymer film is made of at least one of the following materials: a crosslinked product of chitosan and sodium alginate, chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, or an ethyl cellulose complex; and / or, the micropores have a pore size of 0.05 μm to 5 μm; and / or, the capsule shell has a thickness of 10 μm to 200 μm. In this embodiment, the release rate of the antioxidant is controlled by adjusting the thickness, composition, and micropores of the polymer film to achieve the desired release rate.
[0038] In some embodiments, the polymer film is made of polylactic acid or polyvinyl alcohol, with a micropore size of 0.05~5μm and a thickness of 10~200μm. Polylactic acid has advantages such as biocompatibility, biodegradability, precise and long-lasting controlled release, dense film formation, and good mechanical strength. Polyvinyl alcohol swells in water to form a hydrophilic gel film layer, through which the drug needs to be slowly diffused and released to achieve sustained release. Furthermore, the gel film can buffer the initial burst release of the drug, improving the stability of drug release. By using polylactic acid or polyvinyl alcohol and adjusting the thickness, composition, and micropore size, the release rate of the antioxidant can be controlled to achieve the desired release speed.
[0039] In one embodiment, the antioxidant includes at least one of the following: a complex of chlorogenic acid and a co-antioxidant, chlorogenic acid, butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT). In some embodiments, the co-antioxidant may include at least one of the following: propyl gallate (PG) and ascorbyl palmitate (AP).
[0040] Butyl hydroxyanisole (BHA) releases hydrogen atoms through its phenolic hydroxyl group, which combine with free radicals generated by the oxidation of fats and oils, interrupting the oxidation chain reaction. At the same time, it can inhibit the formation of peroxides and has a good antioxidant effect on animal fats, vegetable oils and other oils.
[0041] Butylated hydroxytoluene (BHT) scavenge free radicals by providing hydrogen atoms and has a long-lasting antioxidant effect. It is often used in combination with BHA to exert a synergistic effect and further enhance the antioxidant effect.
[0042] Chlorogenic acid scavenges free radicals by providing phenolic hydroxyl groups, terminating the oxidation chain reaction. It can also chelate metal ions (such as iron and copper), reducing metal-catalyzed oxidation reactions. The synergistic effect of these antioxidants is manifested in the following ways: propyl gallate (PG) can supplement the free radical scavenging capacity of chlorogenic acid, especially in oil systems; ascorbyl palmitate (AP), as a reducing agent, can reduce the intermediates of chlorogenic acid oxidation, regenerating them into their active form and extending the antioxidant cycle.
[0043] In some embodiments, the antioxidant inside the antioxidant capsule may be liquid, solid, etc., and this application is not limited thereto.
[0044] In some embodiments, the antioxidant capsule may further include a carrier group, with the antioxidant and the carrier group forming a core. The formed core may be in a solid state, such as a gel. In this embodiment, the antioxidant is at least partially encapsulated within the carrier group, further contributing to the sustained-release effect.
[0045] In one embodiment, the antioxidant accounts for 10wt% to 70wt% of the antioxidant capsule mass.
[0046] The proportion of antioxidants in the shell mass needs to satisfy the antioxidant capacity during the aging process of the entire atomization matrix, and also ensure the stability of the capsule shell to avoid breakage and other issues.
[0047] Specifically, the antioxidant accounts for 10 wt%, 30 wt%, 50 wt%, 70 wt% of the antioxidant capsule mass, or any value within the above range.
[0048] This application also provides an atomizing liquid comprising an atomizing matrix containing water and / or glycerol and / or propylene glycol, and antioxidant capsules from any of the above embodiments. For example, the atomizing liquid is sold separately, wherein the atomizing liquid contains antioxidant capsules from the embodiments of this application, and the antioxidant capsules are placed within the atomizing matrix, which can effectively extend the antioxidant cycle of the atomizing matrix.
[0049] This application also provides an atomizing device, including the antioxidant capsule of any of the above embodiments.
[0050] In some embodiments, the atomizing device includes at least one single-capsule antioxidant capsule; and / or, the atomizing device includes multiple microcapsule-shaped antioxidant capsules, and the atomizing device also includes a carrier on which the microcapsule-shaped antioxidant capsules are fixed.
[0051] In some embodiments, the particle size of a single antioxidant capsule is 0.2 mm to 5 mm; specifically, the size of a single antioxidant capsule is 0.2 mm, 1 mm, 2 mm, 3 mm, 5 mm or any value within the above range.
[0052] In some embodiments, the particle size of the microcapsule-form antioxidant capsule is 50 μm to 500 μm; specifically, the particle size of the microcapsule-form antioxidant capsule is 50 μm, 150 μm, 350 μm, 500 μm or any value within the above range.
[0053] In some embodiments, the carrier is a polymer material.
[0054] In some embodiments, the atomizing device includes: a reservoir for storing an atomizing matrix comprising water and / or glycerol and / or propylene glycol, an atomizing core, and a liquid guide; the liquid guide transfers the atomizing matrix in the reservoir to the atomizing core; and an antioxidant capsule is disposed within the reservoir or the liquid guide.
[0055] The atomizing device can be a battery-free device, such as a cartridge; or a battery-containing device, such as a cartridge and a device. They can be integrated or detachable.
[0056] In some embodiments, the carrier mentioned above can simultaneously serve as a liquid guide and a liquid storage container, meaning that the liquid guide and liquid storage container can be directly used as carriers for fixing antioxidant capsules in the form of microcapsules.
[0057] In one embodiment, a single antioxidant capsule can be placed directly in the atomizing matrix in the reservoir, or it can be fixed to the inner wall of the reservoir.
[0058] In one embodiment, multiple microcapsule-shaped antioxidant capsules are fixed on a carrier (such as a polymer material), and the size of the microcapsule-shaped antioxidant capsules is 50μm to 500μm. Fixing multiple microcapsule-shaped antioxidant capsules on the carrier means further integrating microcapsules with a particle size of 50μm to 500μm into a larger, more positionable structure to solve the problems of microparticle delivery and oil blockage. For example, multiple microcapsule-shaped antioxidant capsules can be embedded or dispersed in a porous block (0.5 mm) formed of polyurethane or similar materials. In a 5mm diameter, porous blocks can be implanted into the fluid-conducting core. Alternatively, multiple microcapsule-shaped antioxidant capsules can be dispersed in a coatable polymer (such as ethyl cellulose) coating, and then printed or coated onto the inner wall of the chamber to form a sustained-release band.
[0059] In one embodiment, the antioxidant content in the antioxidant capsule accounts for 0.05wt% to 2.0wt% of the atomizing matrix. The antioxidant content in the antioxidant capsule relative to the atomizing liquid needs to ensure sufficient antioxidant capacity while avoiding excessive antioxidants that could lead to system instability due to the accumulation of their own oxidation products or reactions with other components in the atomizing matrix (such as fragrances or metal ions).
[0060] Specifically, the antioxidant content in the antioxidant capsule as a percentage of the atomizing matrix can be 0.05wt%, 0.1wt%, 2.0wt%, or any value within the above range.
[0061] This invention also provides a method for preparing antioxidant capsules, specifically a method for preparing oil-soluble antioxidant capsules: Step 1: Dissolve the oil-soluble antioxidant and the shell material in a volatile organic solvent to form a homogeneous oil phase.
[0062] Among them, oil-soluble antioxidants include at least one of the following: butylated hydroxyanisole and butylated hydroxytoluene.
[0063] The shell material includes at least one of the following: a cross-linked product of chitosan and sodium alginate, chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, or ethyl cellulose complex.
[0064] The organic solvent includes at least one of the following: ethyl acetate and dichloromethane.
[0065] The dissolution temperature is 20℃~40℃.
[0066] The antioxidant and the shell material have mass fractions of 0.1%~5% and 1%~10% in the oil phase, respectively.
[0067] Step 2: Add or inject the oil phase from Step 1 into the aqueous phase containing the emulsifying stabilizer polyvinyl alcohol (PVA) under high-speed stirring to form stable and uniform emulsion droplets.
[0068] The stirring speed is 800 rpm to 1500 rpm, and the stirring time is 2 to 5 hours.
[0069] The PVA mass fraction in the aqueous phase of polyvinyl alcohol is 2wt%~10wt%, and the volume ratio of the aqueous phase to the oil phase of polyvinyl alcohol is 5~10.
[0070] Step 3: Maintain stirring at 200 rpm to 500 rpm and ventilate at 35°C to 50°C for 4 to 12 hours to slowly evaporate the organic solvent. After the organic solvent evaporates, the outer shell material solidifies into a shell, simultaneously forming a porous structure, i.e., the initial capsule.
[0071] Step 4: Wash the initial capsules 2 with deionized water The material was dried three times at 20-40℃ for 13-24 hours, and finally sieved to obtain a 0.5mm sample. 2mm capsules.
[0072] The specific methods for preparing water-soluble antioxidant capsules include: Step 1: Dissolve the water-soluble antioxidant in the chitosan solution to form a positively charged polymer solution.
[0073] The water-soluble antioxidant includes at least one of the following: chlorogenic acid, a compound of chlorogenic acid and propyl gallate, or a compound of chlorogenic acid and ascorbyl palmitate; wherein the chitosan concentration in the positively charged polymer solution is 0.5%. 2.0wt%.
[0074] The pH value of the positively charged polymer solution is 4.0. 5.5.
[0075] Step 2: Mix the sodium alginate negatively charged polymer solution and CaCl2 solution, and simultaneously add the positively charged polymer solution dropwise to form a hydrogel core through a cross-linking reaction.
[0076] In the sodium alginate negatively charged polymer solution, the mass fraction of sodium alginate is 1.0%. 3.0 wt%. Of which, CaCl2 solution contains Ca... 2+ The concentration is 1.0%. 5.0 wt%.
[0077] The volume ratio of sodium alginate negatively charged polymer solution, CaCl2 solution, and positively charged polymer solution is (10~20):(1~5):(5~10).
[0078] Step 3: Immerse the hydrogel core in the shell material solution for secondary coating to obtain a hydrophobic outer layer, and finally obtain an antioxidant capsule after drying.
[0079] The outer shell material is either ethyl cellulose or polyvinyl alcohol, and the mass fraction of the outer shell material in the solution is 2%. 5wt%.
[0080] The coating time is 10. 30 minutes, coating thickness of 10 50μm.
[0081] The parameters for the drying process include: drying temperature less than 40℃ and drying time of 12 to 24 hours.
[0082] The dried antioxidant capsules contain 5-12 wt% water.
[0083] To better explain this solution, specific embodiments are provided below.
[0084] Example 1 Step 1: Dissolve the oil-soluble antioxidant butylated hydroxyanisole (BHA) and the shell material polylactic acid (PLA) in the volatile organic solvent ethyl acetate at 20°C to form a homogeneous oil phase.
[0085] The antioxidant butylated hydroxyanisole and the shell material polylactic acid have mass percentages of 0.1% and 1% in the oil phase, respectively.
[0086] Step 2: Stir the oil phase at high speed at 800 rpm and add the aqueous phase containing the emulsifying stabilizer polyvinyl alcohol (PVA) dropwise to form stable and uniform emulsion droplets.
[0087] The aqueous phase of polyvinyl alcohol (PVA) contains 2% PVA by mass, and the volume ratio of the aqueous phase to the oil phase of PVA is 5.
[0088] Step 3: Maintain stirring at 200 rpm and aerate at 35°C for 4 hours to slowly evaporate the organic solvent. After the organic solvent evaporates, the PLA solidifies into a shell, simultaneously forming a porous structure, i.e., the initial capsule.
[0089] Step 4: Wash the initial capsules three times with deionized water and dry them at 20°C for 13 hours. Finally, obtain the antioxidant capsules by sieving.
[0090] The prepared antioxidant capsules were placed in a 5ml atomizing matrix containing no antioxidants, wherein the total amount of antioxidants contained in the antioxidant capsules placed in the atomizing matrix was 50mg.
[0091] Example 2 The difference from Example 1 is that the antioxidant is butylated hydroxytoluene.
[0092] Example 3 The difference from Example 1 is that the shell material is ethyl cellulose.
[0093] Example 4 The difference from Example 1 is that the antioxidant butylated hydroxyanisole and the shell material polylactic acid have a mass percentage of 5% and 10% in the oil phase, respectively.
[0094] Example 5 The difference from Example 1 is that the antioxidant butylated hydroxyanisole and the shell material polylactic acid have a mass percentage of 3% and 5% in the oil phase, respectively.
[0095] Example 6 The difference from Example 1 is that the mass fraction of PVA in the aqueous phase of polyvinyl alcohol (PVA) is 2%, and the volume ratio of the aqueous phase to the oil phase of polyvinyl alcohol is 10.
[0096] Example 7 The difference from Example 1 is that the mass fraction of PVA in the aqueous phase of polyvinyl alcohol (PVA) is 10%, and the volume ratio of the aqueous phase to the oil phase of polyvinyl alcohol is 5.
[0097] Example 8 The difference from Example 1 is that the mass fraction of PVA in the aqueous phase of polyvinyl alcohol (PVA) is 6%, and the volume ratio of the aqueous phase to the oil phase of polyvinyl alcohol is 8.
[0098] Example 9 Step 1: Dissolve the water-soluble antioxidant in the chitosan solution to form a positively charged polymer solution.
[0099] The water-soluble antioxidant is a compound of chlorogenic acid and propyl gallate; the concentration of chitosan in the positively charged polymer solution is 1 wt%.
[0100] The pH value of the positively charged polymer solution is 5.
[0101] Step 2: Mix the sodium alginate negatively charged polymer solution and CaCl2 solution, and simultaneously add the positively charged polymer solution dropwise to form a hydrogel core through a cross-linking reaction.
[0102] In the sodium alginate negatively charged polymer solution, the mass fraction of sodium alginate is 2 wt%. In the CaCl2 solution, Ca... 2+ The concentration is 3.0 wt%.
[0103] The volume ratio of the sodium alginate negatively charged polymer solution, CaCl2 solution, and positively charged polymer solution is 15:2:8.
[0104] Step 3: Immerse the hydrogel core in the shell material solution for secondary coating to obtain a hydrophobic outer layer, and finally obtain an antioxidant capsule after drying.
[0105] The outer shell material is ethyl cellulose, and the mass fraction of the outer shell material in the solution is 3 wt%.
[0106] The coating time was 20 minutes and the coating thickness was 50 μm.
[0107] The drying parameters include: a drying temperature of 30°C, a drying time of 16 hours, and a water content of 7 wt% for the dried antioxidant capsules.
[0108] The prepared antioxidant capsules were placed in the same 5 ml atomization matrix as in Example 1. The total amount of antioxidants contained in the antioxidant capsules placed in the atomization matrix was 50 mg.
[0109] Example 10 The difference from Example 9 is that the water-soluble antioxidant is chlorogenic acid.
[0110] Comparative Example 1 Take 5 ml of the same atomizing matrix as in Example 1 without adding any antioxidants.
[0111] Comparative Example 2 Take 5 ml of the same atomizing matrix as in Example 1 and mix it directly with an equal amount (i.e., 50 mg) of the antioxidant butylated hydroxyanisole (BHA) as in Example 1.
[0112] Verification test Experiment 1 - Color Evaluation The color changes of the atomized matrix in Examples 1-10 and Comparative Examples 1-2 were observed using CIE Lab measurements after 8 weeks. The Lab values of the initial atomized matrix and the atomized matrix after 8 weeks were measured, and the color difference parameter ΔE was calculated. ab Through ΔE ab Size determines the degree of color change, ΔE ab The larger the value, the more significant the color change; data is shown in Table 1.
[0113] Experiment 2 - Flavor Evaluation The antioxidant capsules prepared in Examples 1-10 were placed in 5 ml of identical antioxidant-free atomizing matrix and aged at 45-55°C and 60-75% RH. The antioxidant content in the atomizing matrix was measured using GC-MS after 14 weeks. The low initial content and slow increase indicate that the antioxidant capsules do not significantly interfere with other components. Furthermore, the sustained-release effect can be verified by analyzing the sustained-release content of the antioxidant at different time points; data are shown in Table 2.
[0114] Table 1 Test Data for Examples and Comparative Examples
[0115] Table 2. Antioxidant Release Content in Antioxidant Capsules of Examples
[0116] As can be seen from the data in Table 1, compared with Comparative Examples 1 and 2, the ΔEab of Examples 1 to 10 is smaller, indicating that the antioxidant capsule has antioxidant function and maintains the original color of the atomized matrix.
[0117] As shown in Table 2, the initial dissolution concentration of the antioxidant in the examples was low and increased slowly, significantly reducing its impact on the flavor of substances such as fragrances. Furthermore, Table 2 also shows that the release rate of the antioxidant capsules within the first two weeks was 0.5–20 μg / mL. - ¹·day- ¹ indicates that the antioxidant capsule has a good sustained-release effect.
[0118] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0119] Although embodiments of this application have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the claims and their equivalents.
Claims
1. An antioxidant capsule, characterized in that, The antioxidant capsule comprises: a capsule shell and an antioxidant; The antioxidant is stored inside the capsule shell; the capsule shell has permeable micropores; when the antioxidant capsule is placed in water and / or glycerol and / or propylene glycol, the antioxidant in the antioxidant capsule can be released into the water and / or glycerol and / or propylene glycol through the micropores of the capsule shell, wherein the release rate of the antioxidant in the antioxidant capsule is 0.5~20 μg·mL for at least two weeks from the time of placement in water and / or glycerol and / or propylene glycol. - ¹·day - ¹.
2. The antioxidant capsule according to claim 1, characterized in that, The capsule shell is a polymer film; wherein the polymer film is made of at least one of the following materials: a crosslinked product of chitosan and sodium alginate, chitosan, polylactic acid, polyvinyl alcohol, ethyl cellulose, or an ethyl cellulose complex; and / or, The pore size of the micropores is 0.05 μm to 5 μm; and / or, The thickness of the capsule shell is 10μm~200μm.
3. The antioxidant capsule according to claim 2, characterized in that, The antioxidant includes at least one of the following: a compound of chlorogenic acid and a co-antioxidant, chlorogenic acid, butylated hydroxyanisole, and butylated hydroxytoluene.
4. The antioxidant capsule according to claim 3, characterized in that, Meet at least one of the following: The ethyl cellulose complex includes at least one of the following: a complex of ethyl cellulose and polyvinylpyrrolidone, or a complex of ethyl cellulose and hydroxypropyl methylcellulose; The antioxidant includes at least one of the following: propyl gallate and ascorbate palmitate.
5. The antioxidant capsule according to any one of claims 1 to 4, characterized in that, The antioxidant accounts for 10wt% to 70wt% of the mass of the antioxidant capsule.
6. An atomizing fluid, characterized in that, The atomizing liquid contains water and / or glycerin and / or propylene glycol, and further includes an antioxidant capsule as described in any one of claims 1 to 5.
7. An atomizing device, characterized in that, Includes the antioxidant capsules according to any one of claims 1 to 5.
8. The atomizing device according to claim 7, characterized in that, The atomizing device includes at least one single-capsule form of the antioxidant. And / or, the atomizing device includes a plurality of antioxidant capsules in the form of microcapsules; optionally, the atomizing device further includes a carrier on which the antioxidant capsules in the form of microcapsules are fixed.
9. The atomizing device according to claim 8, characterized in that, Meet at least one of the following: The particle size of the single-capsule antioxidant is 0.2 mm to 5 mm; The antioxidant capsules in the microcapsule form have a particle size of 50 μm to 500 μm; The carrier is a polymer material.
10. The atomizing device according to claim 8, characterized in that, The atomizing device includes: a reservoir for storing an atomizing matrix containing water and / or glycerol and / or propylene glycol, an atomizing core, and a liquid guiding component; the liquid guiding component transfers the atomizing matrix in the reservoir to the atomizing core; and the antioxidant capsule is disposed in the reservoir or the liquid guiding component.
11. The atomizing device according to claim 10, characterized in that, The antioxidant content in the antioxidant capsule is 0.05wt%~2.0wt% of the atomizing matrix, and / or, The antioxidant capsule is disposed in the reservoir in at least one of the following locations: the inner wall of the reservoir, or the interior of the reservoir.