Traditional Chinese medicine composition for hepatopathy as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions. The invention provides a traditional Chinese medicine composition for liver diseases as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-24 parts of rhizoma smilacis glabrae, 8-12 parts of felwort, 5-7 parts of salvia miltiorrhiza, 5-7 parts of rhizoma corydalis, 8-12 parts of radix paeoniae alba, 4-6 parts of bighead atractylodes rhizome, 14-18 parts of paris polyphylla, 10-14 parts of wild jujube pulp, 6-10 parts of smoked plum pulp and 4-6 parts of sweet almond. The traditional Chinese medicine composition disclosed by the invention is low in raw material cost, wide in source, simple in preparation process and convenient to operate, and provides convenience for large-scale production of medicaments. The prepared product can effectively treat chronic hepatitis, is remarkable in effect, quick in curative effect and high in recovery rate, and can remarkably improve the immunity of a human body.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition for liver diseases, its preparation method and application. Background Technology

[0002] When hepatitis viruses invade the body and are not cleared by the body in time, they can cause chronic and severe liver damage, leading to chronic hepatitis. The course of chronic hepatitis lasts at least 6 months. Clinically, it may present with corresponding symptoms, signs, and abnormal liver biochemical tests, or it may be asymptomatic, with only necrosis and inflammation of liver tissue. The course of the disease is fluctuating or continuously progressive; without appropriate treatment, some patients may progress to cirrhosis.

[0003] While improving diet and avoiding alcohol intake can prevent hepatitis to some extent, they cannot cure it. Treatment for hepatitis still requires medication. Although Traditional Chinese Medicine (TCM) does not have a definition for chronic hepatitis, its clinical symptoms fall within the range of conditions such as jaundice, acute jaundice, hypochondriac pain, and general weakness. Developing TCM remedies for hepatitis can expand the applications of TCM, better improve patients' immunity, and reduce their suffering. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition for liver diseases, its preparation method and application, which can effectively treat chronic hepatitis, with significant effects, rapid efficacy and high recovery rate, and can significantly improve the body's immunity.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0006] This invention provides a traditional Chinese medicine composition for liver disease, prepared from the following raw materials in parts by weight: 20-24 parts of Smilax glabra, 8-12 parts of Gentiana scabra, 5-7 parts of Salvia miltiorrhiza, 5-7 parts of Corydalis yanhusuo, 8-12 parts of Paeonia lactiflora, 4-6 parts of Atractylodes macrocephala, 14-18 parts of Paris polyphylla, 10-14 parts of Ziziphus jujuba var. spinosa, 6-10 parts of Prunus mume, and 4-6 parts of Prunus armeniaca.

[0007] As a preferred option, it is prepared from the following raw materials in parts by weight: 22 parts of Smilax glabra, 10 parts of Gentiana scabra, 6 parts of Salvia miltiorrhiza, 6 parts of Corydalis yanhusuo, 10 parts of Paeonia lactiflora, 5 parts of Atractylodes macrocephala, 16 parts of Paris polyphylla, 12 parts of Ziziphus jujuba var. spinosa, 8 parts of Prunus mume, and 5 parts of Prunus armeniaca var. chinensis.

[0008] The present invention also provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps:

[0009] (1) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1;

[0010] (2) After soaking material 1 in water, boil it, filter it to obtain filtrate 1 and filter residue;

[0011] (3) Add water to the filter residue and boil it a second time. After filtration, filtrate 2 is obtained.

[0012] (4) After steaming the jujube pulp, dried plum pulp and sweet almond pulp, they are mashed into a paste to obtain material 2;

[0013] (5) Mix filtrate 1, filtrate 2 and material 2, and concentrate them into an extract to obtain the Chinese medicine composition.

[0014] Preferably, in step (2), the mass ratio of material 1 to water is 1:8 to 12, the soaking time is 4 to 6 hours, and the decocting time is 30 to 40 minutes.

[0015] Preferably, the mass ratio of filter residue to water in step (3) is 1:2 to 4, and the time for the second decoction is 5 to 15 minutes.

[0016] Preferably, the steaming time in step (4) is 25 to 35 minutes.

[0017] Preferably, the concentration in step (5) is performed under reduced pressure, the temperature of which is 60–64°C, and the relative density of the extract is 1.18–1.22 g / cm³. 3 .

[0018] The present invention also provides the use of the described composition in the preparation of a medicament for treating chronic hepatitis.

[0019] The present invention also provides a medicament for treating chronic hepatitis, the medicament comprising the aforementioned composition.

[0020] Preferably, the drug also includes medically acceptable excipients, and the dosage form of the drug is granules, capsules, or decoction.

[0021] This invention provides a traditional Chinese medicine composition for liver disease, its preparation method, and its application. The composition is prepared from the following raw materials in parts by weight: 20-24 parts of Smilax glabra, 8-12 parts of Gentiana scabra, 5-7 parts of Salvia miltiorrhiza, 5-7 parts of Corydalis yanhusuo, 8-12 parts of Paeonia lactiflora, 4-6 parts of Atractylodes macrocephala, 14-18 parts of Paris polyphylla, 10-14 parts of Ziziphus jujuba var. spinosa, 6-10 parts of Prunus mume, and 4-6 parts of Prunus armeniaca. The raw materials used in this composition are low-cost, widely available, and the preparation process is simple and convenient, facilitating large-scale production. The prepared product can effectively treat chronic hepatitis, showing significant efficacy, rapid therapeutic effect, and high recovery rate, and can significantly improve the body's immunity. Detailed Implementation

[0022] This invention provides a traditional Chinese medicine composition for liver disease, prepared from the following raw materials in parts by weight: 20-24 parts of Smilax glabra, 8-12 parts of Gentiana scabra, 5-7 parts of Salvia miltiorrhiza, 5-7 parts of Corydalis yanhusuo, 8-12 parts of Paeonia lactiflora, 4-6 parts of Atractylodes macrocephala, 14-18 parts of Paris polyphylla, 10-14 parts of Ziziphus jujuba var. spinosa, 6-10 parts of Prunus mume, and 4-6 parts of Prunus armeniaca.

[0023] In this invention, the traditional Chinese medicine composition is preferably prepared from the following raw materials in parts by weight: 22 parts of Smilax glabra, 10 parts of Gentiana scabra, 6 parts of Salvia miltiorrhiza, 6 parts of Corydalis yanhusuo, 10 parts of Paeonia lactiflora, 5 parts of Atractylodes macrocephala, 16 parts of Paris polyphylla, 12 parts of Ziziphus jujuba var. spinosa, 8 parts of Prunus mume, and 5 parts of Prunus armeniaca var. chinensis.

[0024] The present invention also provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps:

[0025] (1) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1;

[0026] (2) After soaking material 1 in water, boil it, filter it to obtain filtrate 1 and filter residue;

[0027] (3) Add water to the filter residue and boil it a second time. After filtration, filtrate 2 is obtained.

[0028] (4) After steaming the jujube pulp, dried plum pulp and sweet almond pulp, they are mashed into a paste to obtain material 2;

[0029] (5) Mix filtrate 1, filtrate 2 and material 2, and concentrate them into an extract to obtain the Chinese medicine composition.

[0030] In this invention, the mass ratio of material 1 to water in step (2) is preferably 1:8 to 12, more preferably 1:10, the soaking time is preferably 4 to 6 hours, more preferably 5 hours, and the decocting time is preferably 30 to 40 minutes, more preferably 35 minutes.

[0031] In this invention, the mass ratio of filter residue to water in step (3) is preferably 1:2 to 4, more preferably 1:3, and the time for the second decoction is preferably 5 to 15 min, more preferably 10 min.

[0032] In this invention, the steaming time in step (4) is preferably 25 to 35 minutes, and more preferably 30 minutes.

[0033] In this invention, the concentration in step (5) is preferably carried out under reduced pressure, and the temperature of the reduced pressure concentration is preferably 60-64°C, more preferably 62°C. The relative density of the extract is preferably 1.18-1.22 g / cm³. 3 Further preferred value is 1.20 g / cm³.3 .

[0034] The present invention also provides the use of the described composition in the preparation of a medicament for treating chronic hepatitis.

[0035] The present invention also provides a medicament for treating chronic hepatitis, the medicament comprising the aforementioned composition.

[0036] In this invention, the drug preferably further includes medically acceptable excipients, and the dosage form of the drug is preferably granules, capsules, or decoction.

[0037] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0038] Example 1

[0039] A method for preparing a traditional Chinese medicine composition for liver disease includes the following steps:

[0040] (1) Weigh out the raw materials according to the following weight proportions: 20 parts of Smilax glabra, 12 parts of Gentiana scabra, 5 parts of Salvia miltiorrhiza, 5 parts of Corydalis yanhusuo, 8 parts of Paeonia lactiflora, 6 parts of Atractylodes macrocephala, 14 parts of Paris polyphylla, 14 parts of Ziziphus jujuba var. spinosa, 10 parts of Prunus mume, and 6 parts of Prunus armeniaca.

[0041] (2) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1;

[0042] (3) Add 8 times the mass of water to material 1, soak for 6 hours, boil for 30 minutes, filter to obtain filtrate 1 and filter residue;

[0043] (4) Add 4 times the mass of water to the filter residue, boil for 5 minutes, filter to obtain filtrate 2;

[0044] (5) After steaming the jujube pulp, dried plum pulp and sweet almond for 35 minutes, grind them into a paste to obtain material 2;

[0045] (6) Mix filtrate 1, filtrate 2 and material 2, and concentrate at 60℃ to a relative density of 1.18 g / cm³. 3 The extract yields the aforementioned traditional Chinese medicine composition.

[0046] Example 2

[0047] A method for preparing a traditional Chinese medicine composition for liver disease includes the following steps:

[0048] (1) Weigh the raw materials according to the following weight proportions: 24 parts of Smilax glabra, 8 parts of Gentiana scabra, 7 parts of Salvia miltiorrhiza, 7 parts of Corydalis yanhusuo, 12 parts of Paeonia lactiflora, 4 parts of Atractylodes macrocephala, 18 parts of Paris polyphylla, 10 parts of Ziziphus jujuba var. spinosa, 6 parts of Prunus mume, and 4 parts of Prunus armeniaca var. spp.

[0049] (2) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1;

[0050] (3) Add 12 times the mass of water to material 1, soak for 4 hours, boil for 40 minutes, filter to obtain filtrate 1 and filter residue;

[0051] (4) Add twice the mass of water to the filter residue, boil for 15 minutes, filter and obtain filtrate 2;

[0052] (5) Steam the jujube pulp, dried plum pulp and sweet almond for 25 minutes and then mash them to obtain material 2;

[0053] (6) Mix filtrate 1, filtrate 2 and material 2, and concentrate at 64℃ to a relative density of 1.22 g / cm³. 3 The extract yields the aforementioned traditional Chinese medicine composition.

[0054] Example 3

[0055] A method for preparing a traditional Chinese medicine composition for liver disease includes the following steps:

[0056] (1) Weigh the raw materials according to the following weight proportions: 22 parts of Smilax glabra, 10 parts of Gentiana scabra, 6 parts of Salvia miltiorrhiza, 6 parts of Corydalis yanhusuo, 10 parts of Paeonia lactiflora, 5 parts of Atractylodes macrocephala, 16 parts of Paris polyphylla, 12 parts of Ziziphus jujuba var. spinosa, 8 parts of Prunus mume, and 5 parts of Prunus armeniaca var. spp.

[0057] (2) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1;

[0058] (3) Add 10 times the mass of water to material 1, soak for 5 hours, boil for 35 minutes, filter to obtain filtrate 1 and filter residue;

[0059] (4) Add 3 times the mass of water to the filter residue, boil for 10 minutes for a second time, and filter to obtain filtrate 2;

[0060] (5) After steaming the jujube pulp, dried plum pulp and sweet almond for 30 minutes, blend them into a paste to obtain material 2;

[0061] (6) Mix filtrate 1, filtrate 2 and material 2, and concentrate at 62℃ to a relative density of 1.20 g / cm³. 3 The extract yields the aforementioned traditional Chinese medicine composition.

[0062] Test case

[0063] Fifteen volunteers with chronic hepatitis were recruited from the outpatient clinic, including 13 patients with mild hepatitis and 2 patients with moderate hepatitis. All patients signed informed consent forms. The patients were aged between 34 and 47 years old, including 9 men and 6 women. The volunteers were randomly divided into three groups of 5 people each, designated as experimental groups 1 to 3.

[0064] Volunteers in experimental group 1 took the traditional Chinese medicine composition prepared in Example 1, volunteers in experimental group 2 took the traditional Chinese medicine composition prepared in Example 2, and volunteers in experimental group 3 took the traditional Chinese medicine composition prepared in Example 3. The dosage was 0.4g twice daily, morning and evening, diluted with water. The experiment lasted for 30 days. After 30 days, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, and direct bilirubin in each group of volunteers were measured.

[0065] Results: All volunteers in experimental group 1 completed the experiment, and their alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, and direct bilirubin levels returned to normal.

[0066] All volunteers in experimental group 2 completed the experiment. Among them, the alanine aminotransferase, aspartate aminotransferase, total bilirubin and direct bilirubin levels of 4 volunteers returned to normal, while the alanine aminotransferase level of the other volunteer was slightly high, but it was significantly lower than before the start of the experiment.

[0067] One volunteer in experimental group 3 withdrew from the trial on day 9 due to failure to take medication on time. Four volunteers completed the trial, and the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, and direct bilirubin in the remaining four volunteers returned to normal.

[0068] As can be seen from the above embodiments, the present invention provides a traditional Chinese medicine composition for liver diseases, its preparation method, and its application. The traditional Chinese medicine composition is prepared from raw materials comprising the following parts by weight: 20-24 parts of Smilax glabra, 8-12 parts of Gentiana scabra, 5-7 parts of Salvia miltiorrhiza, 5-7 parts of Corydalis yanhusuo, 8-12 parts of Paeonia lactiflora, 4-6 parts of Atractylodes macrocephala, 14-18 parts of Paris polyphylla, 10-14 parts of Ziziphus jujuba var. spinosa, 6-10 parts of Prunus mume, and 4-6 parts of Prunus armeniaca. The traditional Chinese medicine composition of the present invention uses low-cost, widely available raw materials, has a simple preparation process, and is easy to operate, providing convenience for large-scale production of pharmaceuticals. The prepared product can effectively treat chronic hepatitis, with significant efficacy, rapid therapeutic effect, and high recovery rate, and can significantly improve the body's immunity.

[0069] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for liver disease, characterized in that, It is prepared from the following raw materials in parts by weight: 20-24 parts of Smilax glabra, 8-12 parts of Gentiana scabra, 5-7 parts of Salvia miltiorrhiza, 5-7 parts of Corydalis yanhusuo, 8-12 parts of Paeonia lactiflora, 4-6 parts of Atractylodes macrocephala, 14-18 parts of Paris polyphylla, 10-14 parts of Ziziphus jujuba var. spinosa, 6-10 parts of Prunus mume, and 4-6 parts of Prunus armeniaca.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Prepared from the following raw materials in parts by weight: 22 parts Smilax glabra, 10 parts Gentiana scabra, 6 parts Salvia miltiorrhiza, 6 parts Corydalis yanhusuo, 10 parts Paeonia lactiflora, 5 parts Atractylodes macrocephala, 16 parts Paris polyphylla, 12 parts Ziziphus jujuba var. spinosa, 8 parts Prunus mume, and 5 parts Prunus armeniaca var. sarcodactylis.

3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, characterized in that, Includes the following steps: (1) Mix Smilax glabra, Gentiana scabra, Salvia miltiorrhiza, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala and Paris polyphylla to obtain material 1; (2) After soaking material 1 in water, boil it, filter it to obtain filtrate 1 and filter residue; (3) Add water to the filter residue and boil it a second time. After filtration, filtrate 2 is obtained. (4) After steaming the jujube pulp, dried plum pulp and sweet almond pulp, they are mashed into a paste to obtain material 2; (5) Mix filtrate 1, filtrate 2 and material 2, and concentrate them into an extract to obtain the Chinese medicine composition.

4. The preparation method according to claim 3, characterized in that, In step (2), the mass ratio of material 1 to water is 1:8 to 12, the soaking time is 4 to 6 hours, and the decocting time is 30 to 40 minutes.

5. The preparation method according to claim 4, characterized in that, The mass ratio of filter residue to water in step (3) is 1:2 to 4, and the second decoction time is 5 to 15 minutes.

6. The preparation method according to claim 5, characterized in that, The steaming time in step (4) is 25 to 35 minutes.

7. The preparation method according to any one of claims 3 to 6, characterized in that, In step (5), the concentration is performed under reduced pressure at a temperature of 60–64°C, and the relative density of the extract is 1.18–1.22 g / cm³. 3 .

8. Use of the composition according to claim 1 or 2 in the preparation of a medicament for treating chronic hepatitis.

9. A drug for treating chronic hepatitis, characterized in that, The drug comprises the composition according to claim 1 or 2.

10. The medicament according to claim 9, characterized in that, The drug also includes medically acceptable excipients, and the dosage form of the drug is granules, capsules, or decoction.